DE69939335D1 - Dispergierbares konzentrat zur verabreichung von cyclosporin - Google Patents
Dispergierbares konzentrat zur verabreichung von cyclosporinInfo
- Publication number
- DE69939335D1 DE69939335D1 DE69939335T DE69939335T DE69939335D1 DE 69939335 D1 DE69939335 D1 DE 69939335D1 DE 69939335 T DE69939335 T DE 69939335T DE 69939335 T DE69939335 T DE 69939335T DE 69939335 D1 DE69939335 D1 DE 69939335D1
- Authority
- DE
- Germany
- Prior art keywords
- surfactant
- formulation
- cyclosporin
- administration
- less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
- 229930105110 Cyclosporin A Natural products 0.000 title abstract 2
- 108010036949 Cyclosporine Proteins 0.000 title abstract 2
- 229960001265 ciclosporin Drugs 0.000 title abstract 2
- 229930182912 cyclosporin Natural products 0.000 title abstract 2
- 239000004491 dispersible concentrate Substances 0.000 title 1
- 238000009472 formulation Methods 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- 239000004094 surface-active agent Substances 0.000 abstract 4
- -1 fatty acid ester Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 239000008389 polyethoxylated castor oil Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 abstract 1
- 229940093633 tricaprin Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22337898A | 1998-12-30 | 1998-12-30 | |
| PCT/IL1999/000710 WO2000040219A1 (en) | 1998-12-30 | 1999-12-30 | Dispersible concentrate for the delivery of cyclosporin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69939335D1 true DE69939335D1 (de) | 2008-09-25 |
Family
ID=22836258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69939335T Expired - Lifetime DE69939335D1 (de) | 1998-12-30 | 1999-12-30 | Dispergierbares konzentrat zur verabreichung von cyclosporin |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7026290B1 (de) |
| EP (1) | EP1154759B1 (de) |
| JP (1) | JP2002534370A (de) |
| AT (1) | ATE404172T1 (de) |
| AU (1) | AU769429C (de) |
| CA (1) | CA2358448C (de) |
| DE (1) | DE69939335D1 (de) |
| DK (1) | DK1154759T3 (de) |
| IL (1) | IL143604A0 (de) |
| NZ (1) | NZ512599A (de) |
| PT (1) | PT1154759E (de) |
| WO (1) | WO2000040219A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9912476D0 (en) * | 1999-05-28 | 1999-07-28 | Novartis Ag | Organic compounds |
| ES2241663T3 (es) * | 1999-09-21 | 2005-11-01 | Skyepharma Canada Inc. | Composiciones particuladas modificadas superficialmente de substancias biologicamente activas. |
| AU2006201100B2 (en) * | 1999-09-21 | 2009-09-24 | Jagotec Ag | Surface modified particulate compositions of biologically active substances |
| US7919113B2 (en) * | 1999-12-30 | 2011-04-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Dispersible concentrate lipospheres for delivery of active agents |
| US7732404B2 (en) * | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| AUPR510001A0 (en) * | 2001-05-18 | 2001-06-14 | Jupitar Pty Ltd | Formulation and method |
| MXPA04000014A (es) | 2001-06-21 | 2004-05-21 | Pfizer Prod Inc | Formulaciones autoemulsionantes de inhibidores de la proteina de transferencia de colesteril ester. |
| AU2002952597A0 (en) * | 2002-11-11 | 2002-11-28 | Schering-Plough Pty. Limited | Topical parasiticide formulations and methods of treatment |
| DE102006051512A1 (de) * | 2005-12-06 | 2007-06-14 | Pari GmbH Spezialisten für effektive Inhalation | Pharmazeutische Medikamentenzusammensetzungen mit Cyclosporin |
| DE102006050026A1 (de) * | 2006-10-13 | 2008-04-17 | Bio Mac- Privatinstitut für medizinische und zahnmedizinische Forschung, Entwicklung und Diagnostik GmbH | Verwendung von Verbindungen und pharmazeutische Zusammensetzung zur Suppression des Immunsystems |
| GB0623838D0 (en) * | 2006-11-29 | 2007-01-10 | Malvern Cosmeceutics Ltd | Novel compositions |
| GB2451811A (en) * | 2007-08-09 | 2009-02-18 | Ems Sa | Delivery composition for solubilising water-insoluble pharmaceutical active ingredients |
| MX2010003364A (es) | 2007-10-08 | 2010-07-06 | Lux Biosciences Inc | Composiciones oftalmicas que comprenden inhibidores de calcineurina o inhibidores de mtor. |
| MX338355B (es) | 2009-06-09 | 2016-04-13 | Aurinia Pharmaceuticals Inc | Sistemas de suministro de farmaco topico para uso oftalmico. |
| KR101586791B1 (ko) * | 2012-12-28 | 2016-01-19 | 주식회사 종근당 | ＧｎＲＨ 유도체의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물 |
| US20150352176A1 (en) * | 2014-06-06 | 2015-12-10 | Newport Research, Inc. | Oil-free and fat-free aqueous suspensions of cyclosporin |
| US20200237859A1 (en) | 2019-01-25 | 2020-07-30 | Newport Research, Inc. | Aqueous suspensions of cyclosporin |
| US11324800B2 (en) | 2015-01-15 | 2022-05-10 | Wellspring Ophthalmics, Inc. | Aqueous suspensions of cyclosporin |
| US20190224275A1 (en) | 2017-05-12 | 2019-07-25 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
Family Cites Families (88)
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|---|---|---|---|---|
| US4117118A (en) | 1976-04-09 | 1978-09-26 | Sandoz Ltd. | Organic compounds |
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| US4215199A (en) | 1978-06-05 | 1980-07-29 | Sandoz Ltd. | Antibiotic production |
| DE3167014D1 (en) | 1980-02-14 | 1984-12-13 | Sandoz Ag | A method for the total synthesis of cyclosporins and novel cyclosporins |
| US5639724A (en) | 1984-07-24 | 1997-06-17 | Sandoz Ltd. | Cyclosporin galenic forms |
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| US5154930A (en) | 1987-03-05 | 1992-10-13 | The Liposome Company, Inc. | Pharmacological agent-lipid solution preparation |
| KR880012221A (ko) | 1987-04-13 | 1988-11-26 | 사노 가즈오 | 에스테르 또는 아미드를 활성성분으로 함유하는 약제 조성물 |
| EP0296122B1 (de) | 1987-06-17 | 1993-09-29 | Sandoz Ag | Cyclosporine und deren Benutzung als Arzneimittel |
| US5756450A (en) | 1987-09-15 | 1998-05-26 | Novartis Corporation | Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms |
| US4994267A (en) | 1988-03-04 | 1991-02-19 | Noven Pharmaceuticals, Inc. | Transdermal acrylic multipolymer drug delivery system |
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| US5342625A (en) | 1988-09-16 | 1994-08-30 | Sandoz Ltd. | Pharmaceutical compositions comprising cyclosporins |
| KR0148748B1 (ko) | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
| SE8804164A0 (sv) | 1988-11-17 | 1990-05-18 | Per Prisell | Farmaceutisk beredning |
| HU201577B (en) | 1988-12-20 | 1990-11-28 | Gyogyszerkutato Intezet | Process for producing cyclosporin antibiotics |
| US5272068A (en) | 1989-03-15 | 1993-12-21 | Merck & Co., Inc. | Process for producing immunosuppressant agent L-683942 by fermentation |
| DE69013189T2 (de) | 1989-03-15 | 1995-05-11 | Merck & Co Inc | Verfahren zur Herstellung einer immunosuppressiven Substanz (demethimmunomycin) durch Verwendung eines Stamm-Mutanten eines Mikroorganismus. |
| US5188837A (en) | 1989-11-13 | 1993-02-23 | Nova Pharmaceutical Corporation | Lipsopheres for controlled delivery of substances |
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| US5178866A (en) | 1990-03-23 | 1993-01-12 | Alza Corporation | Dosage form for delivering drug to the intestine |
| ATE148469T1 (de) | 1990-11-02 | 1997-02-15 | Sandoz Ag | Zyklosporine |
| HU208491B (en) | 1990-11-27 | 1993-11-29 | Gyogyszerkutato Intezet | Process for producing oral pharmaceutical composition containing cyclosporin |
| CA2101777A1 (en) | 1991-01-25 | 1992-07-26 | Toshio Goto | Process for producing cyclosporin a and/or c |
| US5378475A (en) | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
| JP2721041B2 (ja) | 1991-04-19 | 1998-03-04 | ネクスター・フアーマシユーテイカルズ・インコーポレイテツド | 医薬調合品及び方法 |
| US5683714A (en) | 1991-04-19 | 1997-11-04 | Nexstar Pharmaceuticals, Inc. | Liposomal cyclosporin pharmaceutical formulation |
| IL101007A (en) | 1992-02-18 | 1997-08-14 | Pharmos Ltd | Dry stable compositions prepared by lyophilization |
| US5529785A (en) | 1993-05-12 | 1996-06-25 | Dietl; Hans | Pharmaceutical preparation containing cyclosporin(s) for oral administration and process for producing same |
| US5637317A (en) | 1992-05-18 | 1997-06-10 | Dietl; Hans | Pharmaceutical preparation containing cyclosporin(s) for oral administration and process for producing same |
| HU213553B (en) | 1992-05-25 | 1997-07-28 | Biogal Gyogyszergyar | Process for isolating of cyclosporin-a |
| US5759566A (en) | 1992-07-28 | 1998-06-02 | Poli Industria Chimica Spa | Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents |
| SK278290B6 (en) | 1992-09-07 | 1996-08-07 | Milan Stuchlik | Medicaments with n-methylated cyclic undecapeptides |
| FI92334C (fi) | 1992-12-30 | 1994-10-25 | Leiras Oy | Menetelmä syklosporiinien tuottamiseksi ja menetelmässä käytettävä uusi Tolypocladium-kanta |
| ES2115231T3 (es) | 1993-04-20 | 1998-06-16 | Hexal Ag | Emplasto con sustancias activas. |
| US5576016A (en) | 1993-05-18 | 1996-11-19 | Pharmos Corporation | Solid fat nanoemulsions as drug delivery vehicles |
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| US5639474A (en) | 1993-07-01 | 1997-06-17 | Hanmi Pharm. Ind., Ltd. | Cyclosporin soft capsule composition |
| ES2308955T5 (es) | 1993-09-28 | 2012-04-03 | R.P. Scherer Gmbh | Fabricación de cápsulas de gelatina blanda |
| DE4340781C3 (de) | 1993-11-30 | 2000-01-27 | Novartis Ag | Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung |
| WO1995020943A1 (en) * | 1994-02-04 | 1995-08-10 | Scotia Lipidteknik Ab | Oil-in-water emulsions |
| US5891846A (en) | 1994-02-17 | 1999-04-06 | Shiseido Company, Ltd. | Cyclosporin-containing emulsion composition |
| KR0146671B1 (ko) | 1994-02-25 | 1998-08-17 | 김충환 | 사이클로스포린-함유 분말 조성물 |
| GB9405304D0 (en) | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
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| JP2936209B2 (ja) | 1994-06-01 | 1999-08-23 | ユーハン コーポレーション | サイクロスポリン含有組成物およびその製造方法 |
| US5958458A (en) | 1994-06-15 | 1999-09-28 | Dumex-Alpharma A/S | Pharmaceutical multiple unit particulate formulation in the form of coated cores |
| KR100304324B1 (ko) | 1994-10-13 | 2001-11-22 | 김용규 | 사이클로스포린a의제조방법 |
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| US5603951A (en) | 1994-11-09 | 1997-02-18 | Hanmi Pharm. Ind. Co., Ltd. | Cyclosporin-containing soft capsule compositions |
| DE4440337A1 (de) | 1994-11-11 | 1996-05-15 | Dds Drug Delivery Services Ges | Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit |
| HU215966B (hu) | 1994-11-21 | 1999-07-28 | BIOGAL Gyógyszergyár Rt. | Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum |
| KR0167613B1 (ko) | 1994-12-28 | 1999-01-15 | 한스 루돌프 하우스, 니콜 케르커 | 사이클로스포린-함유 연질캅셀제 조성물 |
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| US5573783A (en) | 1995-02-13 | 1996-11-12 | Nano Systems L.L.C. | Redispersible nanoparticulate film matrices with protective overcoats |
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| IE75744B1 (en) | 1995-04-03 | 1997-09-24 | Elan Corp Plc | Controlled release biodegradable micro- and nanospheres containing cyclosporin |
| AU692255B2 (en) | 1995-04-24 | 1998-06-04 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Self-emulsifiable formulation producing an oil-in-water emulsion |
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| EP0760237A1 (de) | 1995-08-30 | 1997-03-05 | Cipla Limited | Öl-in-Wasser-Mikroemulsionen |
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| NZ280689A (en) | 1995-12-15 | 1997-08-22 | Bernard Charles Sherma Sherman | Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol |
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| US5958876A (en) | 1996-06-19 | 1999-09-28 | Novartis Ag | Cyclosporin-containing pharmaceutical compositions |
| US5958378A (en) | 1996-07-03 | 1999-09-28 | Research Development Foundation | High dose liposomal aerosol formulations containing cyclosporin A or budesonide |
| KR980008239A (ko) | 1996-07-26 | 1998-04-30 | 김충환 | 사이클로스포린-함유 약학적 조성물 |
| US5798333A (en) | 1996-09-17 | 1998-08-25 | Sherman; Bernard C. | Water-soluble concentrates containing cyclosporins |
| JP4718653B2 (ja) | 1997-03-12 | 2011-07-06 | アボツト・ラボラトリーズ | シクロスポリンの投与のための親水性二成分系 |
| US5891845A (en) | 1997-11-21 | 1999-04-06 | Fuisz Technologies Ltd. | Drug delivery systems utilizing liquid crystal structures |
| US6028067A (en) | 1997-12-05 | 2000-02-22 | Chong Kun Dang Corp. | Cyclosporin-containing microemulsion preconcentrate composition |
| ID25908A (id) * | 1998-03-06 | 2000-11-09 | Novartis Ag | Prakonsentrat-prakonsentrat emulsi yang mengandung siklosporin atau makrolida |
| FR2780061B1 (fr) | 1998-06-22 | 2001-09-07 | Rhone Poulenc Rorer Sa | Nouveau procede de preparation de derives de cyclosporine |
| US6267985B1 (en) | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
| US6057289A (en) | 1999-04-30 | 2000-05-02 | Pharmasolutions, Inc. | Pharmaceutical composition comprising cyclosporin in association with a carrier in a self-emulsifying drug delivery system |
| MXPA04000014A (es) * | 2001-06-21 | 2004-05-21 | Pfizer Prod Inc | Formulaciones autoemulsionantes de inhibidores de la proteina de transferencia de colesteril ester. |
-
1999
- 1999-12-30 JP JP2000591976A patent/JP2002534370A/ja active Pending
- 1999-12-30 DK DK99961269T patent/DK1154759T3/da active
- 1999-12-30 AT AT99961269T patent/ATE404172T1/de active
- 1999-12-30 WO PCT/IL1999/000710 patent/WO2000040219A1/en active IP Right Grant
- 1999-12-30 EP EP99961269A patent/EP1154759B1/de not_active Expired - Lifetime
- 1999-12-30 US US09/869,519 patent/US7026290B1/en not_active Expired - Fee Related
- 1999-12-30 CA CA002358448A patent/CA2358448C/en not_active Expired - Fee Related
- 1999-12-30 DE DE69939335T patent/DE69939335D1/de not_active Expired - Lifetime
- 1999-12-30 PT PT99961269T patent/PT1154759E/pt unknown
- 1999-12-30 IL IL14360499A patent/IL143604A0/xx active IP Right Grant
- 1999-12-30 NZ NZ512599A patent/NZ512599A/en not_active IP Right Cessation
- 1999-12-30 AU AU17962/00A patent/AU769429C/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US7026290B1 (en) | 2006-04-11 |
| EP1154759A4 (de) | 2005-07-20 |
| JP2002534370A (ja) | 2002-10-15 |
| PT1154759E (pt) | 2008-11-20 |
| DK1154759T3 (da) | 2008-12-08 |
| ATE404172T1 (de) | 2008-08-15 |
| AU769429C (en) | 2004-10-28 |
| CA2358448C (en) | 2009-02-10 |
| EP1154759A1 (de) | 2001-11-21 |
| AU769429B2 (en) | 2004-01-29 |
| AU1796200A (en) | 2000-07-24 |
| IL143604A0 (en) | 2002-04-21 |
| CA2358448A1 (en) | 2000-07-13 |
| NZ512599A (en) | 2003-10-31 |
| WO2000040219A1 (en) | 2000-07-13 |
| EP1154759B1 (de) | 2008-08-13 |
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