DE69939605D1 - Oral verabreichbare galenische Form enthaltend Metformin und einen Absorptionspromoter - Google Patents

Oral verabreichbare galenische Form enthaltend Metformin und einen Absorptionspromoter

Info

Publication number
DE69939605D1
DE69939605D1 DE69939605T DE69939605T DE69939605D1 DE 69939605 D1 DE69939605 D1 DE 69939605D1 DE 69939605 T DE69939605 T DE 69939605T DE 69939605 T DE69939605 T DE 69939605T DE 69939605 D1 DE69939605 D1 DE 69939605D1
Authority
DE
Germany
Prior art keywords
form containing
orally administrable
absorption promoter
galenic form
containing metformin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69939605T
Other languages
English (en)
Inventor
Olivier Saslawski
Philippe Giet
Dominique Revol
Thierry Hulot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of DE69939605D1 publication Critical patent/DE69939605D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
DE69939605T 1998-02-23 1999-02-16 Oral verabreichbare galenische Form enthaltend Metformin und einen Absorptionspromoter Expired - Lifetime DE69939605D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9802143A FR2775188B1 (fr) 1998-02-23 1998-02-23 Forme galenique a liberation immediate ou liberation prolongee administrable par voie orale comprenant un agent promoteur d'absorption et utilisation de cet agent promoteur d'absorption

Publications (1)

Publication Number Publication Date
DE69939605D1 true DE69939605D1 (de) 2008-10-30

Family

ID=9523244

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69917750T Expired - Lifetime DE69917750T2 (de) 1998-02-23 1999-02-16 Oral verabreichbare galenische form mit rascher freisetzung und mit verzögerter freisetzung, enthaltend ein absorbtionspromoter und verwendung dieses absorbtionspromoters
DE69939605T Expired - Lifetime DE69939605D1 (de) 1998-02-23 1999-02-16 Oral verabreichbare galenische Form enthaltend Metformin und einen Absorptionspromoter

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69917750T Expired - Lifetime DE69917750T2 (de) 1998-02-23 1999-02-16 Oral verabreichbare galenische form mit rascher freisetzung und mit verzögerter freisetzung, enthaltend ein absorbtionspromoter und verwendung dieses absorbtionspromoters

Country Status (28)

Country Link
US (2) US6426087B1 (de)
EP (2) EP1410791B1 (de)
JP (1) JP4828020B2 (de)
KR (1) KR100587181B1 (de)
CN (1) CN1182837C (de)
AP (1) AP2000001943A0 (de)
AR (2) AR018109A1 (de)
AT (2) ATE268164T1 (de)
AU (1) AU750785B2 (de)
BR (1) BR9908121A (de)
CA (1) CA2321267C (de)
CZ (1) CZ299366B6 (de)
DE (2) DE69917750T2 (de)
DK (2) DK1056445T3 (de)
ES (2) ES2222695T3 (de)
FR (1) FR2775188B1 (de)
HK (1) HK1035142A1 (de)
HU (1) HU226732B1 (de)
ID (1) ID26022A (de)
NO (1) NO20004190L (de)
OA (1) OA11454A (de)
PL (2) PL201851B1 (de)
PT (2) PT1410791E (de)
RU (1) RU2228201C2 (de)
SI (2) SI1056445T1 (de)
SK (2) SK285188B6 (de)
WO (1) WO1999042086A1 (de)
ZA (1) ZA991408B (de)

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US5858398A (en) * 1994-11-03 1999-01-12 Isomed Inc. Microparticular pharmaceutical compositions
GB9516268D0 (en) * 1995-08-08 1995-10-11 Danbiosyst Uk Compositiion for enhanced uptake of polar drugs from the colon

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AR018109A1 (es) 2001-10-31
DK1410791T3 (da) 2009-01-12
ES2222695T3 (es) 2005-02-01
HK1035142A1 (en) 2001-11-16
ATE268164T1 (de) 2004-06-15
KR20010034537A (ko) 2001-04-25
HUP0100970A3 (en) 2001-12-28
ID26022A (id) 2000-11-16
NO20004190D0 (no) 2000-08-22
US6426087B1 (en) 2002-07-30
EP1056445A1 (de) 2000-12-06
FR2775188A1 (fr) 1999-08-27
ATE408399T1 (de) 2008-10-15
PL191415B1 (pl) 2006-05-31
EP1056445B1 (de) 2004-06-02
RU2228201C2 (ru) 2004-05-10
JP2002503686A (ja) 2002-02-05
AU3140899A (en) 1999-09-06
KR100587181B1 (ko) 2006-06-08
PL201851B1 (pl) 2009-05-29
ZA991408B (en) 1999-08-23
SK286248B6 (sk) 2008-06-06
CA2321267C (en) 2007-04-17
CA2321267A1 (en) 1999-08-26
EP1410791B1 (de) 2008-09-17
EP1410791A1 (de) 2004-04-21
HU226732B1 (en) 2009-08-28
NO20004190L (no) 2000-10-20
BR9908121A (pt) 2000-10-24
HUP0100970A2 (hu) 2001-08-28
AP2000001943A0 (en) 2000-12-31
DE69917750T2 (de) 2005-05-25
CN1182837C (zh) 2005-01-05
WO1999042086A9 (en) 2000-08-31
SI1410791T1 (sl) 2009-02-28
OA11454A (en) 2003-12-08
US6514524B1 (en) 2003-02-04
SK285188B6 (sk) 2006-08-03
WO1999042086A1 (en) 1999-08-26
CN1291091A (zh) 2001-04-11
PT1410791E (pt) 2008-12-24
DE69917750D1 (de) 2004-07-08
ES2314302T3 (es) 2009-03-16
CZ299366B6 (cs) 2008-07-02
SK12552000A3 (sk) 2001-02-12
PL342162A1 (en) 2001-05-21
FR2775188B1 (fr) 2001-03-09
PT1056445E (pt) 2004-10-29
DK1056445T3 (da) 2004-10-04
CZ20002940A3 (cs) 2000-11-15
AU750785B2 (en) 2002-07-25
JP4828020B2 (ja) 2011-11-30
AR066843A2 (es) 2009-09-16
SI1056445T1 (en) 2004-10-31

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