DE69940608D1 - Vorrichtung zur effizienten hämodiafiltration - Google Patents
Vorrichtung zur effizienten hämodiafiltrationInfo
- Publication number
- DE69940608D1 DE69940608D1 DE69940608T DE69940608T DE69940608D1 DE 69940608 D1 DE69940608 D1 DE 69940608D1 DE 69940608 T DE69940608 T DE 69940608T DE 69940608 T DE69940608 T DE 69940608T DE 69940608 D1 DE69940608 D1 DE 69940608D1
- Authority
- DE
- Germany
- Prior art keywords
- dialyzer
- dialyzer cartridge
- hemodia
- filtration
- efficient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3424—Substitution fluid path
- A61M1/3431—Substitution fluid path upstream of the filter
- A61M1/3434—Substitution fluid path upstream of the filter with pre-dilution and post-dilution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3424—Substitution fluid path
- A61M1/3437—Substitution fluid path downstream of the filter, e.g. post-dilution with filtrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3455—Substitution fluids
- A61M1/3465—Substitution fluids using dialysate as substitution fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3623—Means for actively controlling temperature of blood
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S210/00—Liquid purification or separation
- Y10S210/929—Hemoultrafiltrate volume measurement or control processes
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9489898P | 1998-07-31 | 1998-07-31 | |
PCT/US1999/017468 WO2000006292A1 (en) | 1998-07-31 | 1999-07-30 | Method for efficient hemodiafiltration |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69940608D1 true DE69940608D1 (de) | 2009-04-30 |
Family
ID=22247800
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69940608T Expired - Lifetime DE69940608D1 (de) | 1998-07-31 | 1999-07-30 | Vorrichtung zur effizienten hämodiafiltration |
Country Status (9)
Country | Link |
---|---|
US (1) | US6303036B1 (de) |
EP (1) | EP1119404B2 (de) |
JP (1) | JP4334771B2 (de) |
AT (1) | ATE425808T1 (de) |
AU (1) | AU5669799A (de) |
CA (1) | CA2338952C (de) |
DE (1) | DE69940608D1 (de) |
ES (1) | ES2324506T3 (de) |
WO (1) | WO2000006292A1 (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000025902A1 (en) * | 1998-10-30 | 2000-05-11 | Nephros, Inc. | Non-isosmotic diafiltration system |
US6406631B1 (en) * | 1999-07-30 | 2002-06-18 | Nephros, Inc. | Two stage diafiltration method and apparatus |
EP1095666A1 (de) * | 1999-10-29 | 2001-05-02 | Infomed S.A. | Vorrichtung zur extrakorporalen Blutreinigung |
US6315895B1 (en) | 1999-12-30 | 2001-11-13 | Nephros, Inc. | Dual-stage hemodiafiltration cartridge |
EP1261413A4 (de) * | 2000-01-11 | 2006-02-01 | Nephros Inc | Thermisch verbessertes dialyse-/diafiltrationssystem |
US7067060B2 (en) * | 2000-01-11 | 2006-06-27 | Nephros, Inc. | Ionic enhanced dialysis/diafiltration system |
ES2344140T3 (es) | 2000-10-30 | 2010-08-19 | Nephros Inc | Cartucho de filtracion de dos etapas. |
JP4025199B2 (ja) | 2000-12-08 | 2007-12-19 | ネフロス・インコーポレーテッド | 流体搬送装置、及び注入液装置の使用上の安全性を高める装置 |
JP4053421B2 (ja) * | 2000-12-11 | 2008-02-27 | ネフロス・インコーポレーテッド | 血液透析濾過/血液濾過カートリッジ |
AU2002235257A1 (en) * | 2000-12-20 | 2002-07-01 | Nephros, Inc. | Multistage hemodiafiltration/hemofiltration method and apparatus |
US6916424B2 (en) | 2001-02-07 | 2005-07-12 | Nephros, Inc. | Method and apparatus for a hemodiafiltration delivery module |
US20030010718A1 (en) | 2001-07-12 | 2003-01-16 | Nxstage Medical, Inc. | Hemodilution cap and methods of use in blood-processing procedures |
US7115206B2 (en) * | 2002-10-15 | 2006-10-03 | Gambro Lundia Ab | Method for in-line preparation of liquid for an extracorporeal blood treatment apparatus |
US7429324B2 (en) * | 2002-10-15 | 2008-09-30 | Gambro Lundia Ab | Device for in-line preparation of liquid for an extracorporeal blood treatment apparatus |
JP3958733B2 (ja) * | 2002-11-14 | 2007-08-15 | 日機装株式会社 | 血液浄化装置 |
US20040111079A1 (en) * | 2002-12-03 | 2004-06-10 | Richard Hayes | Targeted sanguinous drug solution delivery to a targeted organ |
EP1444998A1 (de) * | 2003-02-05 | 2004-08-11 | B. Braun Medizintechnologie GmbH | Behandlungsvorrichtung für eine biologische Flüssigkeit |
ITMI20030212A1 (it) * | 2003-02-07 | 2004-08-08 | Gambro Lundia Ab | Metodo per il trattamento extracorporeo di sangue |
US7314554B2 (en) | 2003-02-07 | 2008-01-01 | Gambro Lundia Ab | Extracorporeal blood treatment machine |
US8029454B2 (en) | 2003-11-05 | 2011-10-04 | Baxter International Inc. | High convection home hemodialysis/hemofiltration and sorbent system |
BRPI0620935B8 (pt) * | 2005-12-29 | 2021-06-22 | Cuva Aps | método e aparelho para díalise em casa |
WO2008053260A1 (en) * | 2006-10-30 | 2008-05-08 | Gambro Lundia Ab | An extracorporeal blood chamber |
US8708943B2 (en) * | 2006-10-30 | 2014-04-29 | Gambro Lundia Ab | Hemo(dia) filtration apparatus |
ES2375210T3 (es) * | 2006-10-30 | 2012-02-27 | Gambro Lundia Ab | Separador de aire para conjuntos de tratamiento de fluido extracorpóreo. |
US8105487B2 (en) | 2007-09-25 | 2012-01-31 | Fresenius Medical Care Holdings, Inc. | Manifolds for use in conducting dialysis |
US8597505B2 (en) | 2007-09-13 | 2013-12-03 | Fresenius Medical Care Holdings, Inc. | Portable dialysis machine |
US8040493B2 (en) | 2007-10-11 | 2011-10-18 | Fresenius Medical Care Holdings, Inc. | Thermal flow meter |
US9308307B2 (en) | 2007-09-13 | 2016-04-12 | Fresenius Medical Care Holdings, Inc. | Manifold diaphragms |
US8240636B2 (en) | 2009-01-12 | 2012-08-14 | Fresenius Medical Care Holdings, Inc. | Valve system |
US9358331B2 (en) | 2007-09-13 | 2016-06-07 | Fresenius Medical Care Holdings, Inc. | Portable dialysis machine with improved reservoir heating system |
US9199022B2 (en) | 2008-09-12 | 2015-12-01 | Fresenius Medical Care Holdings, Inc. | Modular reservoir assembly for a hemodialysis and hemofiltration system |
US8475399B2 (en) | 2009-02-26 | 2013-07-02 | Fresenius Medical Care Holdings, Inc. | Methods and systems for measuring and verifying additives for use in a dialysis machine |
US8535522B2 (en) | 2009-02-12 | 2013-09-17 | Fresenius Medical Care Holdings, Inc. | System and method for detection of disconnection in an extracorporeal blood circuit |
EP2227268B2 (de) | 2007-10-24 | 2023-08-23 | Nikkiso Co., Ltd. | Optimierung der clearance von proteingebundenen molekülen mit kaskaden-filtrationstherapie |
MX2010005907A (es) | 2007-11-29 | 2010-12-20 | Fresenius Med Care Hldg Inc | Sistema y metodo para conduccion de hemodialisis y hemofiltracion. |
AU2009302327C1 (en) | 2008-10-07 | 2015-09-10 | Fresenius Medical Care Holdings, Inc. | Priming system and method for dialysis systems |
CA2739807C (en) | 2008-10-30 | 2017-02-28 | Fresenius Medical Care Holdings, Inc. | Modular, portable dialysis system |
US8727744B2 (en) * | 2010-02-26 | 2014-05-20 | Entegris, Inc. | Method and system for optimizing operation of a pump |
US8684705B2 (en) * | 2010-02-26 | 2014-04-01 | Entegris, Inc. | Method and system for controlling operation of a pump based on filter information in a filter information tag |
TWI563351B (en) | 2010-10-20 | 2016-12-21 | Entegris Inc | Method and system for pump priming |
US9201036B2 (en) | 2012-12-21 | 2015-12-01 | Fresenius Medical Care Holdings, Inc. | Method and system of monitoring electrolyte levels and composition using capacitance or induction |
US9157786B2 (en) | 2012-12-24 | 2015-10-13 | Fresenius Medical Care Holdings, Inc. | Load suspension and weighing system for a dialysis machine reservoir |
US9433720B2 (en) | 2013-03-14 | 2016-09-06 | Fresenius Medical Care Holdings, Inc. | Universal portable artificial kidney for hemodialysis and peritoneal dialysis |
US20140263062A1 (en) * | 2013-03-14 | 2014-09-18 | Fresenius Medical Care Holdings, Inc. | Universal portable machine for online hemodiafiltration using regenerated dialysate |
GB201305755D0 (en) | 2013-03-28 | 2013-05-15 | Quanta Fluid Solutions Ltd | Re-Use of a Hemodialysis Cartridge |
US9354640B2 (en) * | 2013-11-11 | 2016-05-31 | Fresenius Medical Care Holdings, Inc. | Smart actuator for valve |
GB201409796D0 (en) | 2014-06-02 | 2014-07-16 | Quanta Fluid Solutions Ltd | Method of heat sanitization of a haemodialysis water circuit using a calculated dose |
GB201523104D0 (en) | 2015-12-30 | 2016-02-10 | Quanta Fluid Solutions Ltd | Dialysis machine |
GB201622119D0 (en) | 2016-12-23 | 2017-02-08 | Quanta Dialysis Tech Ltd | Improved valve leak detection system |
GB201710547D0 (en) * | 2017-06-30 | 2017-08-16 | Quanta Dialysis Tech Ltd | A dialysis system |
US10821216B1 (en) | 2017-07-03 | 2020-11-03 | Nephros Inc. | Method and apparatus for a hemodiafiltration module for use with a dialysis machine |
EP3560577A1 (de) | 2018-04-25 | 2019-10-30 | Gambro Lundia AB | Vorrichtung und verfahren zur integritätsprüfung einer ultrafiltermembran |
JP7098433B2 (ja) * | 2018-06-20 | 2022-07-11 | 日機装株式会社 | 血液浄化装置及び血液浄化装置による血漿流量取得方法 |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3579441A (en) | 1968-04-19 | 1971-05-18 | Hydronautics | Blood purification by dual filtration |
US3946731A (en) | 1971-01-20 | 1976-03-30 | Lichtenstein Eric Stefan | Apparatus for extracorporeal treatment of blood |
FR2231421B1 (de) | 1973-05-30 | 1976-05-07 | Rhone Poulenc Ind | |
US4118314A (en) | 1974-01-09 | 1978-10-03 | Seisan Kaihatsu Kagaku Kenkyusho | Apparatus for treatment of artificial kidney dialyzing fluid |
US3878095A (en) | 1974-05-02 | 1975-04-15 | Advanced Medical Sciences Inc | Dialysis apparatus |
DE2838414C2 (de) | 1978-09-02 | 1984-10-31 | Fresenius AG, 6380 Bad Homburg | Vorrichtung zur Hämodialyse und zum Entziehen von Ultrafiltrat |
JPS5814223B2 (ja) | 1979-02-24 | 1983-03-17 | 株式会社メデクス | 透析「ろ」過装置 |
US4381999A (en) | 1981-04-28 | 1983-05-03 | Cobe Laboratories, Inc. | Automatic ultrafiltration control system |
US4722798A (en) | 1981-06-11 | 1988-02-02 | Baxter Travenol Laboratories, Inc. | Hemodialysis with dialysate osmolarity varied non-linearly with time |
SE425216B (sv) | 1981-10-05 | 1982-09-13 | Gambro Ab | Filtreranordning |
SE427619B (sv) | 1981-10-05 | 1983-04-25 | Gambro Lundia Ab | Filtreranordning |
US4647378A (en) | 1983-03-23 | 1987-03-03 | Nihon Medical Engineering Co., Ltd. | Blood dialyzing method and apparatus |
DE3326704A1 (de) * | 1983-07-23 | 1985-01-31 | Josef 6902 Sandhausen Magasi | Verfahren und vorrichtung zur haemodialyse |
DE3444671A1 (de) | 1984-12-07 | 1986-06-12 | Fresenius AG, 6380 Bad Homburg | Haemodiafiltrationsgeraet |
DE3529973A1 (de) | 1985-08-22 | 1987-03-05 | Braun Melsungen Ag | Vorrichtung zur haemodiafiltration |
DE3641843A1 (de) | 1986-12-08 | 1988-06-16 | Fresenius Ag | Haemodialysevorrichtung mit sterilisiereinrichtung |
US4784495A (en) | 1987-02-06 | 1988-11-15 | Gambro Ab | System for preparing a fluid intended for a medical procedure by mixing at least one concentrate in powder form with water |
NO173366C (no) | 1987-11-02 | 1993-12-08 | Tokyo Bi Tech Lab Inc | Membran av hule fibre for rensing av blod, framgangsm}te for rensing av blod, og apparat for rensing av blod |
IT1215765B (it) | 1988-01-22 | 1990-02-22 | Grace W R & Co | Dispositivo di emodiafiltrazione erelativo procedimento di emodiafiltrazione. |
US5069788A (en) | 1989-08-24 | 1991-12-03 | Pfizer Hospital Products Groups, Inc. | Multi-pass blood washing and plasma removal device and method |
US5511875A (en) | 1990-02-19 | 1996-04-30 | Gambro Ab | System for the preparation of a fluid concentrate intended for medical use |
IT1241588B (it) † | 1990-03-09 | 1994-01-19 | Sorin Biomedica Emodialisi S R | Apparecchiatura per la depurazione del sangue, particolarmente per il trattamento di pazienti affetti da insufficienza renale, e procedimentoo per produzione di liquido di reinfusione per emodiafiltrazione (hdf) |
US5194157A (en) * | 1990-03-09 | 1993-03-16 | Sorin Biomedica Emodialisi Srl | Blood purifying equipment particularly for the treatment of patients suffering from renal insufficiency, and a method of producing a reinfusion liquid for haemodiafiltration (HDF) |
FR2660866B1 (fr) * | 1990-04-13 | 1992-06-12 | Hogamed | Procede et dispositif de preparation d'un liquide de substitution. |
US5486286A (en) | 1991-04-19 | 1996-01-23 | Althin Medical, Inc. | Apparatus for performing a self-test of kidney dialysis membrane |
IT1245999B (it) | 1991-05-29 | 1994-11-07 | Bellco Spa | Apparecchiatura per trattamenti di emodiafiltrazione. |
FR2680975B1 (fr) | 1991-09-10 | 1998-12-31 | Hospal Ind | Rein artificiel muni de moyens pour doser une substance dans le sang. |
US5244568A (en) | 1991-11-15 | 1993-09-14 | Baxter International Inc. | Automated hemodialysis chemical treatment system with control valve and proportioning pumps |
FR2687307B1 (fr) | 1992-02-14 | 1999-06-04 | Lascombes Jean Jacques | Dispositif pour la preparation d'une solution a usage medical. |
FR2691364B1 (fr) | 1992-05-19 | 1999-08-20 | Hospal Ind | Rein artificiel avec dispositif de filtration du liquide de dialyse. |
DE4309410A1 (de) | 1993-03-19 | 1995-02-16 | Stange Jan | Material, Verfahren und Einrichtung zur selektiven Trennung frei gelöster und stoffgebundener Stoffe aus flüssigen Stoffgemischen sowie Verfahren zur Herstellung des Materials |
FR2704432B1 (fr) | 1993-04-27 | 1995-06-23 | Hospal Ind | Dispositif d'injection de liquide dans un circuit extracorporel de sang. |
DE19523505A1 (de) * | 1994-07-13 | 1996-01-18 | Fresenius Ag | Hämo(dia)filtrationsvorrichtung mit Filtratflußsteuerung |
DE59507027D1 (de) | 1994-07-13 | 1999-11-18 | Fresenius Medical Care De Gmbh | Substituataufbereitung bei der Hämofiltration oder Hämodiafiltration |
FR2723002B1 (fr) | 1994-07-26 | 1996-09-06 | Hospal Ind | Dispositif et procede pour preparer un liquide de traitement par filtration |
US5591344A (en) † | 1995-02-13 | 1997-01-07 | Aksys, Ltd. | Hot water disinfection of dialysis machines, including the extracorporeal circuit thereof |
DE19534417A1 (de) | 1995-09-16 | 1997-03-20 | Fresenius Ag | Verfahren zum Überprüfen von mindestens einem im Dialysierflüssigkeitssystem einer Vorrichtung zur extrakorporalen Blutbehandlung angeordneten Filter |
US5711883A (en) | 1995-09-27 | 1998-01-27 | Fresenius Usa, Inc. | Method for testing dialyzer integrity prior to use |
DE19607162C2 (de) † | 1996-02-26 | 1998-01-15 | Fresenius Ag | Verwendung eines Dialysators mit zwei Modulen zur Durchführung eines Verfahrens zum Filtrieren und sofortigen Verwenden von Substituatflüssigkeit in einer Hämodialfiltrationsvorrichtung |
DE19700466A1 (de) † | 1997-01-09 | 1998-07-16 | Polaschegg Hans Dietrich Dr | Einrichtung und Verfahren zur Hämodiafiltration |
US20010016699A1 (en) | 1997-02-14 | 2001-08-23 | Jeffrey H. Burbank | Hemofiltration system |
IT1299946B1 (it) | 1998-04-01 | 2000-04-04 | Bellco Spa | Macchina per emodialisi. |
-
1999
- 1999-07-30 AT AT99943641T patent/ATE425808T1/de not_active IP Right Cessation
- 1999-07-30 US US09/485,778 patent/US6303036B1/en not_active Expired - Lifetime
- 1999-07-30 WO PCT/US1999/017468 patent/WO2000006292A1/en active Application Filing
- 1999-07-30 DE DE69940608T patent/DE69940608D1/de not_active Expired - Lifetime
- 1999-07-30 ES ES99943641T patent/ES2324506T3/es not_active Expired - Lifetime
- 1999-07-30 JP JP2000562134A patent/JP4334771B2/ja not_active Expired - Fee Related
- 1999-07-30 EP EP99943641.3A patent/EP1119404B2/de not_active Expired - Lifetime
- 1999-07-30 CA CA002338952A patent/CA2338952C/en not_active Expired - Fee Related
- 1999-07-30 AU AU56697/99A patent/AU5669799A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU5669799A (en) | 2000-02-21 |
ATE425808T1 (de) | 2009-04-15 |
ES2324506T3 (es) | 2009-08-07 |
EP1119404A1 (de) | 2001-08-01 |
EP1119404B1 (de) | 2009-03-18 |
EP1119404B2 (de) | 2013-05-01 |
WO2000006292A1 (en) | 2000-02-10 |
JP2002521162A (ja) | 2002-07-16 |
CA2338952C (en) | 2007-04-03 |
CA2338952A1 (en) | 2000-02-10 |
EP1119404A4 (de) | 2003-05-02 |
JP4334771B2 (ja) | 2009-09-30 |
US6303036B1 (en) | 2001-10-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent |