DE69943247D1 - HIV hemmende Pyrimidin Derivate - Google Patents
HIV hemmende Pyrimidin DerivateInfo
- Publication number
- DE69943247D1 DE69943247D1 DE69943247T DE69943247T DE69943247D1 DE 69943247 D1 DE69943247 D1 DE 69943247D1 DE 69943247 T DE69943247 T DE 69943247T DE 69943247 T DE69943247 T DE 69943247T DE 69943247 D1 DE69943247 D1 DE 69943247D1
- Authority
- DE
- Germany
- Prior art keywords
- hiv
- pyrimidine derivatives
- inhibiting pyrimidine
- inhibiting
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7963298P | 1998-03-27 | 1998-03-27 | |
EP98201587A EP0945442A1 (de) | 1998-03-27 | 1998-05-14 | Trisubstituierte Pyrimidine Derivate |
EP98203948 | 1998-11-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69943247D1 true DE69943247D1 (de) | 2011-04-14 |
Family
ID=43734825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69943247T Expired - Lifetime DE69943247D1 (de) | 1998-03-27 | 1999-03-24 | HIV hemmende Pyrimidin Derivate |
Country Status (6)
Country | Link |
---|---|
US (5) | US6197779B1 (de) |
KR (1) | KR100643419B1 (de) |
AR (1) | AR014785A1 (de) |
BR (1) | BRPI9909191B8 (de) |
DE (1) | DE69943247D1 (de) |
ES (1) | ES2361146T3 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL204427B1 (pl) * | 1998-11-10 | 2010-01-29 | Janssen Pharmaceutica Nv | Hamująca replikację wirusa HIV pochodna pirymidyny, sposób jej wytwarzania i zastosowanie oraz kompozycja farmaceutyczna |
DE19945982A1 (de) | 1999-09-24 | 2001-03-29 | Knoll Ag | Geschwindigkeitsbestimmte Partikel |
IL148801A0 (en) * | 1999-09-24 | 2002-09-12 | Janssen Pharmaceutica Nv | Antiviral compositions |
JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
US8101629B2 (en) * | 2001-08-13 | 2012-01-24 | Janssen Pharmaceutica N.V. | Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile |
US7638522B2 (en) * | 2001-08-13 | 2009-12-29 | Janssen Pharmaceutica N.V. | Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile |
CA2463989C (en) * | 2001-10-17 | 2012-01-31 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pyrimidine derivatives, pharmaceutical compositions containing these compounds, the use thereof and process for the preparation thereof |
EP1453516A2 (de) | 2001-10-17 | 2004-09-08 | Boehringer Ingelheim Pharma GmbH & Co.KG | 5-substituierte 4-amino-2-phenylamino-pyrimdinderivate und ihre verwendung als beta-amyloid modulatoren |
TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
US7288547B2 (en) * | 2002-03-11 | 2007-10-30 | Schering Ag | CDK-inhibitory 2-heteroaryl-pyrimidines, their production and use as pharmaceutical agents |
AU2003216585A1 (en) * | 2002-04-10 | 2003-10-20 | Orchid Chemicals And Pharmaceuticals Limited | Pyrimidinedione derivatives useful for the treatment of inflammation and immunological diseases |
DK1534286T3 (da) | 2002-07-29 | 2010-04-26 | Rigel Pharmaceuticals Inc | Fremgangsmåder til behandling eller forebyggelse af autoimmune sygdomme med 2,4-pyrimidindiamin-forbindelser |
MXPA05001541A (es) * | 2002-08-09 | 2005-04-19 | Janssen Pharmaceutica Nv | Procedimientos para la preparacion de 4-[[4 -[[4- (2-cianoetenil)- 2, 6-dimetilfenil] amino]-2 -pirimidinil] amino] benzonitrilo. |
US20060135556A1 (en) * | 2002-08-23 | 2006-06-22 | Jean-Luc Girardet | Non-nucleoside reverse transcriptase inhibitors |
NZ539823A (en) * | 2002-11-28 | 2008-04-30 | Schering Aktiengessellschaft | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents |
PT1656372E (pt) | 2003-07-30 | 2013-06-27 | Rigel Pharmaceuticals Inc | Métodos para o tratamento ou prevenção de doenças autoimunes com compostos de 2,4-pirimidinadiamina |
CN1956974B (zh) * | 2004-05-19 | 2010-11-24 | 巴斯福股份公司 | 2-取代嘧啶及其作为农药的用途 |
WO2007050087A1 (en) * | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS |
JP4952943B2 (ja) * | 2004-08-25 | 2012-06-13 | アーディア・バイオサイエンシーズ・インコーポレイテッド | HIV逆転写酵素のインヒビターとしてのS−トリアゾリルα−メルカプトアセトアニリド |
ES2371924T3 (es) * | 2004-09-30 | 2012-01-11 | Tibotec Pharmaceuticals | Pirimidinas 5-carbo o heterociclo- sustituidas que inhiben el hiv. |
US7557207B2 (en) | 2004-11-24 | 2009-07-07 | Rigel Pharmaceuticals, Inc. | Spiro 2,4-pyrimidinediamine compounds and their uses |
AU2006206458B2 (en) | 2005-01-19 | 2012-10-25 | Rigel Pharmaceuticals, Inc. | Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
US20060270694A1 (en) * | 2005-05-03 | 2006-11-30 | Rigel Pharmaceuticals, Inc. | JAK kinase inhibitors and their uses |
US8133900B2 (en) * | 2005-11-01 | 2012-03-13 | Targegen, Inc. | Use of bi-aryl meta-pyrimidine inhibitors of kinases |
MY167260A (en) * | 2005-11-01 | 2018-08-14 | Targegen Inc | Bi-aryl meta-pyrimidine inhibitors of kinases |
US8604042B2 (en) * | 2005-11-01 | 2013-12-10 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
US7576092B2 (en) * | 2006-07-11 | 2009-08-18 | Janssen Pharmaceutica N.V. | Benzofuro- and benzothienopyrimidine modulators of the histamine H4 receptor |
MX2009005009A (es) | 2006-11-09 | 2009-09-22 | Ardea Biosciences Inc | Compuestos heterociclicos biciclicos 4-cianofenilamino sustituidos como inhibidores del virus de inmunodeficiencia humana. |
US7989465B2 (en) * | 2007-10-19 | 2011-08-02 | Avila Therapeutics, Inc. | 4,6-disubstituted pyrimidines useful as kinase inhibitors |
JP5600063B2 (ja) | 2007-10-19 | 2014-10-01 | セルジーン アビロミクス リサーチ, インコーポレイテッド | ヘテロアリール化合物およびその使用 |
ME01294B (me) | 2007-11-27 | 2013-06-20 | Ardea Biosciences Inc | Nova jedinjenja i kompozicije i metode upotrebe |
UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
EP2406234A1 (de) * | 2009-03-12 | 2012-01-18 | GlaxoSmithKline LLC | Thiazolsulfonamid- und oxazolsulfonamid-kinasehemmer |
US8367315B2 (en) * | 2010-03-05 | 2013-02-05 | Adan Rios | Inactivation of reverse transcriptases by azido-diarylpyrimidines |
US8354420B2 (en) | 2010-06-04 | 2013-01-15 | Genentech, Inc. | Aminopyrimidine derivatives as LRRK2 inhibitors |
EP2618824A4 (de) | 2010-09-20 | 2015-05-06 | Kareus Therapeutics Sa | Verfahren und zusammensetzungen zur behandlung von diabetes und dyslipidämie |
CA2816957A1 (en) | 2010-11-07 | 2012-05-10 | Targegen, Inc. | Compositions and methods for treating myelofibrosis |
PT3124483T (pt) | 2010-11-10 | 2019-10-02 | Genentech Inc | Derivados de pirazol aminopirimidina como moduladores de lrrk2 |
CA2834257C (en) | 2011-04-25 | 2019-03-12 | Hetero Research Foundation | Process for rilpivirine |
WO2013038425A1 (en) * | 2011-09-16 | 2013-03-21 | Hetero Research Foundation | Rilpivirine hydrochloride |
WO2018195450A1 (en) | 2017-04-21 | 2018-10-25 | Epizyme, Inc. | Combination therapies with ehmt2 inhibitors |
CN111187222B (zh) * | 2020-01-16 | 2021-09-24 | 山东大学 | 一种取代嘧啶类衍生物及其制备方法和应用 |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2478030A (en) * | 1945-05-24 | 1949-08-02 | Gen Electric | Method of making electromagnetic induction apparatus |
US2748124A (en) | 1954-05-06 | 1956-05-29 | Searle & Co | 1-(4-anilino-2-pyrimidino)-3-alkylureas |
GB1010998A (en) | 1962-10-09 | 1965-11-24 | British Petroleum Co | Pyrimidine derivatives |
US3478030A (en) | 1966-06-27 | 1969-11-11 | Abbott Lab | Benzamide substituted anilino aminopyrimidines |
GB1483271A (en) | 1975-03-22 | 1977-08-17 | Ciba Geigy Ag | Pigment complexes |
GB1477349A (en) | 1975-09-24 | 1977-06-22 | Ciba Geigy Ag | Azo pigments |
JPS57203072A (en) * | 1981-06-05 | 1982-12-13 | Sankyo Co Ltd | 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient |
JPS59151386A (ja) | 1983-01-31 | 1984-08-29 | Fujitsu Ltd | 半導体記憶装置 |
US4659363A (en) * | 1983-07-25 | 1987-04-21 | Ciba-Geigy Corporation | N-(2-nitrophenyl)-2-aminopyrimidine derivatives, the preparation and use thereof |
JPH0784445B2 (ja) | 1986-12-03 | 1995-09-13 | クミアイ化学工業株式会社 | ピリミジン誘導体および農園芸用殺菌剤 |
US4980371A (en) * | 1988-12-21 | 1990-12-25 | Merrell Dow Pharmaceuticals | Antiretroviral furan ketones |
IE63502B1 (en) | 1989-04-21 | 1995-05-03 | Zeneca Ltd | Aminopyrimidine derivatives useful for treating cardiovascular disorders |
JPH02300264A (ja) | 1989-05-16 | 1990-12-12 | Fuji Photo Film Co Ltd | アミノピリミジンアゾメチン色素とその製造方法 |
JPH02308248A (ja) | 1989-05-24 | 1990-12-21 | Fuji Photo Film Co Ltd | アミノピリミジン系色素形成カプラーおよび該カプラーを含有するハロゲン化銀カラー写真感光材料 |
US5064963A (en) | 1990-04-25 | 1991-11-12 | American Cyanamid Company | Process for the synthesis of n-(3-(1h-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidinamines |
GB9012592D0 (en) * | 1990-06-06 | 1990-07-25 | Smithkline Beecham Intercredit | Compounds |
JPH04159381A (ja) | 1990-10-23 | 1992-06-02 | Arakawa Chem Ind Co Ltd | ロジンエステルの製造方法 |
IL106324A (en) | 1992-07-17 | 1998-09-24 | Shell Int Research | Transformed pyrimidine compounds, their preparation and use as pesticides |
US5516775A (en) | 1992-08-31 | 1996-05-14 | Ciba-Geigy Corporation | Further use of pyrimidine derivatives |
WO1995010506A1 (en) | 1993-10-12 | 1995-04-20 | The Du Pont Merck Pharmaceutical Company | 1n-alkyl-n-arylpyrimidinamines and derivatives thereof |
GB9325217D0 (en) | 1993-12-09 | 1994-02-09 | Zeneca Ltd | Pyrimidine derivatives |
TW574214B (en) * | 1994-06-08 | 2004-02-01 | Pfizer | Corticotropin releasing factor antagonists |
US5574040A (en) * | 1995-01-06 | 1996-11-12 | Picower Institute For Medical Research | Pyrimidine compounds and methods of use to derivatize neighboring lysine residues in proteins under physiologic conditions |
JP3691101B2 (ja) | 1995-01-24 | 2005-08-31 | 三洋電機株式会社 | 有機エレクトロルミネッセンス素子 |
JPH09101590A (ja) | 1995-07-28 | 1997-04-15 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料およびその包装体 |
US5837436A (en) | 1995-07-28 | 1998-11-17 | Fuji Photo Film Co., Ltd. | Silver halide color photographic material and package thereof |
JPH0968784A (ja) | 1995-08-31 | 1997-03-11 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
JPH0980676A (ja) | 1995-09-13 | 1997-03-28 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料およびその包装体 |
GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
GB9705361D0 (en) * | 1997-03-14 | 1997-04-30 | Celltech Therapeutics Ltd | Chemical compounds |
JP2000111191A (ja) | 1998-08-04 | 2000-04-18 | Tokyo Gas Co Ltd | 吸収冷温水機 |
JP4159381B2 (ja) | 2003-02-24 | 2008-10-01 | 花王株式会社 | 歯ブラシ |
-
1999
- 1999-03-24 DE DE69943247T patent/DE69943247D1/de not_active Expired - Lifetime
- 1999-03-24 ES ES02014566T patent/ES2361146T3/es not_active Expired - Lifetime
- 1999-03-24 KR KR1020007007970A patent/KR100643419B1/ko not_active IP Right Cessation
- 1999-03-24 BR BRPI9909191A patent/BRPI9909191B8/pt active IP Right Grant
- 1999-03-25 US US09/276,360 patent/US6197779B1/en not_active Expired - Lifetime
- 1999-03-26 AR ARP990101364A patent/AR014785A1/es active IP Right Grant
-
2000
- 2000-12-27 US US09/749,181 patent/US6440986B2/en not_active Expired - Lifetime
-
2002
- 2002-06-28 US US10/185,528 patent/US6903213B2/en not_active Expired - Lifetime
-
2005
- 2005-04-21 US US11/111,400 patent/US20050192305A1/en not_active Abandoned
- 2005-04-21 US US11/111,358 patent/US8026248B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR20010034269A (ko) | 2001-04-25 |
US20050192305A1 (en) | 2005-09-01 |
ES2361146T3 (es) | 2011-06-14 |
US20050197354A1 (en) | 2005-09-08 |
BRPI9909191B8 (pt) | 2021-07-06 |
US20010011094A1 (en) | 2001-08-02 |
BR9909191A (pt) | 2000-12-05 |
AR014785A1 (es) | 2001-03-28 |
US8026248B2 (en) | 2011-09-27 |
US20030083317A1 (en) | 2003-05-01 |
KR100643419B1 (ko) | 2006-11-10 |
US6197779B1 (en) | 2001-03-06 |
US6440986B2 (en) | 2002-08-27 |
US6903213B2 (en) | 2005-06-07 |
BRPI9909191B1 (pt) | 2018-04-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69905306T2 (de) | HIV hemmende Pyrimidin Derivate | |
DE69943247D1 (de) | HIV hemmende Pyrimidin Derivate | |
ATE455107T1 (de) | Hiv-replikationshemmende pyrimidine | |
ATE388713T1 (de) | 4-amino-6-phenyl-pyrrolo(2,3-d)pyrimidin derivate | |
ATE256123T1 (de) | Pyrimidonderivate | |
ATE517891T1 (de) | Hiv hemmende pyrimidine derivaten | |
ATE372988T1 (de) | Pyrimidin-derivate | |
ATE284404T1 (de) | Pyrazolo(4,3-d)pyrimidinderivate | |
DK1175408T3 (da) | Pyrimidinonforbindelser | |
NO20022738L (no) | Pyrrolo(2,3-d)pyrimidinforbindelser | |
PT891978E (pt) | Derivados de 5h-tiazolo (3,2-a) pirimidina | |
ATE231866T1 (de) | Pyrazolo(4, 3-d)pyrimidine | |
MA26967A1 (fr) | Derives de pyrimidine | |
DE50103649D1 (de) | 2-aminoalkyl-thieno[2,3-d]pyrimidine | |
DE69617031D1 (de) | Pyrimidin nukleosid derivate | |
ID17477A (id) | Turunan-turunan pirimidina nukleosida |