DE798378T1 - Östrogen-Rezeptor - Google Patents

Östrogen-Rezeptor

Info

Publication number
DE798378T1
DE798378T1 DE0798378T DE97200903T DE798378T1 DE 798378 T1 DE798378 T1 DE 798378T1 DE 0798378 T DE0798378 T DE 0798378T DE 97200903 T DE97200903 T DE 97200903T DE 798378 T1 DE798378 T1 DE 798378T1
Authority
DE
Germany
Prior art keywords
estrogen receptor
receptors
relates
present
dna encoding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE0798378T
Other languages
English (en)
Other versions
DE29700903U1 (de
Inventor
Sietse Mosselman
Rein Dijkema
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26142641&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE798378(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Publication of DE798378T1 publication Critical patent/DE798378T1/de
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • C12N15/72Expression systems using regulatory sequences derived from the lac-operon
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/723Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
DE0798378T 1996-03-26 1997-03-25 Östrogen-Rezeptor Pending DE798378T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96200820 1996-03-26
EP96203284 1996-11-11

Publications (1)

Publication Number Publication Date
DE798378T1 true DE798378T1 (de) 1999-03-04

Family

ID=26142641

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69709561T Revoked DE69709561T2 (de) 1996-03-26 1997-03-25 Östrogen-Rezeptor
DE0798378T Pending DE798378T1 (de) 1996-03-26 1997-03-25 Östrogen-Rezeptor

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69709561T Revoked DE69709561T2 (de) 1996-03-26 1997-03-25 Östrogen-Rezeptor

Country Status (13)

Country Link
US (3) US7060490B1 (de)
EP (2) EP1162264A3 (de)
JP (1) JPH104986A (de)
KR (1) KR19980041692A (de)
AT (1) ATE212055T1 (de)
AU (1) AU715812B2 (de)
CA (1) CA2200423C (de)
DE (2) DE69709561T2 (de)
DK (1) DK0798378T3 (de)
ES (1) ES2123482T3 (de)
GR (1) GR980300076T1 (de)
HK (1) HK1001978A1 (de)
HU (1) HU221411B1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100263137B1 (ko) 1995-09-08 2000-08-01 오테스코그 페르 오판 수용체
US7157568B1 (en) * 1997-08-05 2007-01-02 American Home Products Corporation Human estrogen receptor-β
EP1012177B1 (de) * 1997-09-08 2006-08-09 Merck & Co., Inc. Östrogenrezeptor
US6222015B1 (en) 1997-09-08 2001-04-24 Merck & Co., Inc. Estrogen receptor
DE19839115A1 (de) * 1998-08-27 2000-03-09 Ihf Inst Fuer Hormon Und Fortp Klonierung und Expression von Rinder Estrogenrezeptor-beta
US7528123B1 (en) 1998-11-20 2009-05-05 N.V. Organon Estrogenic estra-1,3,5(10)-trienes with differential effects on the alpha and beta estrogen receptors, having a linear hydrocarbon chain of from 5-9 carbon atoms in position 11
DE19855013C2 (de) * 1998-11-20 2001-09-13 Schering Ag Androgen- und Progesteron-Rezeptor bindendes Hormon Response Element
ATE246703T1 (de) * 1999-04-06 2003-08-15 Akzo Nobel Nv Oral wirksame 7-alpha-alkyl androgene
WO2001064665A1 (en) 2000-03-01 2001-09-07 Akzo Nobel N.V. Chroman derivatives as estrogenic compounds
AU2001249315A1 (en) 2000-03-22 2001-10-03 Rheogene, Inc. Ecdysone receptor-based inducible gene expression system
US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
TWI225068B (en) 2000-06-06 2004-12-11 Akzo Nobel Nv Anellated steroid compounds having contraceptive and anti-osteoporosis activity
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
CA2441444C (en) 2001-02-20 2013-09-03 Rheogene Holdings, Inc. Novel ecdysone receptor/invertebrate retinoid x receptor-based inducible gene expression system
CA2438133C (en) 2001-02-20 2015-01-27 Rheogene, Inc. Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
JP4955905B2 (ja) 2001-02-20 2012-06-20 イントレキソン コーポレーション キメラレチノイドx受容体および新規エクジソン受容体−ベースの誘導性遺伝子発現システムにおけるそれらの使用
CA2445796C (en) 2001-02-20 2014-09-16 Rheogene, Inc. Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
EP1288303A1 (de) * 2001-08-23 2003-03-05 Aventis Pharma S.A. Induzierbare Expressionssysteme unter Verwendung von PPAR Transkriptionsaktivatoren
WO2003012113A2 (en) * 2001-08-02 2003-02-13 Gencell S.A. Inducible expression systems employing ppar transcriptional activators
JP2005532781A (ja) 2001-09-26 2005-11-04 レオジーン・ホールディングス,インコーポレーテッド ヨコバイエクジソン受容体核酸、ポリペプチド、およびそれらの使用
AU2002327787A1 (en) * 2001-09-28 2003-04-07 Gordon L. Hager Glucocorticoid receptor nuclear translocation domain
TW200304371A (en) 2002-02-22 2003-10-01 Akzo Nobel Nv Substituted 10-ary1-11H-benzo [b] fluorenes and 7-ary1-5, 6-dihydro-benz [a] anthracenes for selective effects on estrogen receptors
US7674783B2 (en) 2002-11-22 2010-03-09 Dimera Inc. Estrogen beta receptor agonists to prevent or reduce the severity of cardiovascular disease
US7304161B2 (en) 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7935510B2 (en) 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
UA89964C2 (ru) 2004-09-08 2010-03-25 Н.В. Органон 15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ
SG11201506875YA (en) 2013-03-15 2015-09-29 Intrexon Corp Boron-containing diacylhydrazines
EP3194359B1 (de) 2014-09-17 2020-04-08 Intrexon Corporation Borhaltige diacylhydrazinverbindungen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987005049A1 (en) * 1986-02-20 1987-08-27 California Biotechnology Inc. Eucaryotic expression of steroid receptor proteins
US5217867A (en) * 1988-11-30 1993-06-08 The Salk Institute For Biological Studies Receptors: their identification, characterization, preparation and use
FR2649994A1 (fr) * 1989-06-30 1991-01-25 Aderegem Procede d'obtention d'un recepteur humain natif sauvage des oestrogenes et ses applications
WO1992008133A1 (en) * 1990-10-29 1992-05-14 Dekalb Plant Genetics Isolation of biological materials using magnetic particles
EP0609240B1 (de) * 1991-09-17 2002-04-03 The Salk Institute For Biological Studies Rezeptoren der steroid/thyroid superfamilie von rezeptoren
KR100263137B1 (ko) * 1995-09-08 2000-08-01 오테스코그 페르 오판 수용체
US7157568B1 (en) * 1997-08-05 2007-01-02 American Home Products Corporation Human estrogen receptor-β

Also Published As

Publication number Publication date
EP1162264A3 (de) 2002-05-15
HU9700636D0 (en) 1997-05-28
US6713270B1 (en) 2004-03-30
GR980300076T1 (en) 1998-11-30
DK0798378T3 (da) 2002-04-29
ATE212055T1 (de) 2002-02-15
AU715812B2 (en) 2000-02-10
HUP9700636A3 (en) 1999-01-28
DE69709561D1 (de) 2002-02-21
EP0798378A3 (de) 1997-12-29
HU221411B1 (en) 2002-09-28
KR19980041692A (ko) 1998-08-17
US7060490B1 (en) 2006-06-13
EP0798378A2 (de) 1997-10-01
AU1652197A (en) 1997-10-02
US6680368B1 (en) 2004-01-20
CA2200423A1 (en) 1997-09-26
EP1162264A2 (de) 2001-12-12
ES2123482T3 (es) 2002-11-01
DE69709561T2 (de) 2002-08-29
CA2200423C (en) 2006-12-19
ES2123482T1 (es) 1999-01-16
EP0798378B1 (de) 2002-01-16
HUP9700636A2 (hu) 1998-04-28
HK1001978A1 (en) 1998-07-24
JPH104986A (ja) 1998-01-13

Similar Documents

Publication Publication Date Title
ATE212055T1 (de) Östrogen-rezeptor
HN1997000040A (es) Sal mesilatotrihidroto de 5-2-4-1,2 -benzoisotiazol -3 il 1- piperazinil etil -6 - cloro 13 dihidro 2h indol 2-ona.
ID24583A (id) Turunan-turunan 1,2,3,4-tetrahidronaftalena tersubstitusi
EE9800171A (et) 3-pürasoolkarboksamiidi derivaadid, mis omavad afiinsust kannabinoidretseptori suhtes
NL1008164A1 (nl) Ruimer.
DE69708120T2 (de) Laser-absorbierende, lichtbleichbare zusammensetzungen
BR9706717B1 (pt) mecanismo de distribuição.
TR199700090A2 (tr) Yeni heteroaril-oksazolidinonlar.
DZ2769A1 (fr) Composés tricycliques substitués.
DE69824719D1 (de) Cytokinähnlicher faktor-7 aus säugetieren
CY1107339T1 (el) Mu-1, μελος της οικογενειας υποδοχεα κυτοκινης
IT1303546B1 (it) Cerniera lampo.
ZA992773B (en) Substituted tricyclics.
NO991948D0 (no) Multi-funksjonelle, chimeriske hematopoietiske reseptorantagonister
DE69221823T2 (de) Oxytocin-Rezeptor, dafür kodierende DNS
TR199501389A2 (tr) Adesyon reseptörü antagonistleri (karsitlari).
NO990666D0 (no) FremgangsmÕte for diversitets-kombinering, samt mottaker
DE69725459D1 (de) Substituierte 1,2,3,4-tetrahydro-2-dibenzofuranamine und 2-aminocyclohepta(b)benzofurane
ZA988637B (en) Methods for regulating trkA expression.
ATE310732T1 (de) 7-phenyl-1,4-diazepanderivate als neurokininrezeptorantagonisten
WO2000037634A3 (en) Novel polypeptides and nucleic acids encoding same
ATE231848T1 (de) Substituierte 2-benzoyl-cyclohexan-1,3-dione
TR199601082A3 (tr) Entegrin reseptör antagonistleri.
DE19882714T1 (de) Stufenloser, Industionsgesteuerter Spannungsregler
ES1033403Y (es) Encendedor solar ecologico perfeccionado.