DE869774T1 - Partikel mit verzögerter freisetzung - Google Patents
Partikel mit verzögerter freisetzungInfo
- Publication number
- DE869774T1 DE869774T1 DE0869774T DE96935641T DE869774T1 DE 869774 T1 DE869774 T1 DE 869774T1 DE 0869774 T DE0869774 T DE 0869774T DE 96935641 T DE96935641 T DE 96935641T DE 869774 T1 DE869774 T1 DE 869774T1
- Authority
- DE
- Germany
- Prior art keywords
- core particles
- organic solvent
- active substance
- particle
- delayed release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003111 delayed effect Effects 0.000 title 1
- 239000002245 particle Substances 0.000 title 1
- 239000007771 core particle Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 239000011859 microparticle Substances 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 229940088623 biologically active substance Drugs 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 230000001627 detrimental effect Effects 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9503672A SE505146C2 (sv) | 1995-10-19 | 1995-10-19 | Partiklar för fördröjd frisättning |
PCT/SE1996/001091 WO1997014408A1 (en) | 1995-10-19 | 1996-09-03 | Sustained release particles |
Publications (1)
Publication Number | Publication Date |
---|---|
DE869774T1 true DE869774T1 (de) | 1999-06-02 |
Family
ID=20399887
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE0869774T Pending DE869774T1 (de) | 1995-10-19 | 1996-09-03 | Partikel mit verzögerter freisetzung |
DE69625240T Expired - Fee Related DE69625240T2 (de) | 1995-10-19 | 1996-09-03 | Methode zur herstellung von partikeln mit verzoegerter freisetzung |
DE69636177T Expired - Fee Related DE69636177T2 (de) | 1995-10-19 | 1996-09-03 | Umhüllung kleiner Partikel |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69625240T Expired - Fee Related DE69625240T2 (de) | 1995-10-19 | 1996-09-03 | Methode zur herstellung von partikeln mit verzoegerter freisetzung |
DE69636177T Expired - Fee Related DE69636177T2 (de) | 1995-10-19 | 1996-09-03 | Umhüllung kleiner Partikel |
Country Status (17)
Country | Link |
---|---|
US (1) | US6120787A (de) |
EP (3) | EP1716849A1 (de) |
JP (1) | JP2000501380A (de) |
KR (1) | KR100482262B1 (de) |
AT (2) | ATE228826T1 (de) |
AU (1) | AU699080B2 (de) |
CZ (1) | CZ293059B6 (de) |
DE (3) | DE869774T1 (de) |
DK (1) | DK0869774T3 (de) |
ES (2) | ES2267637T3 (de) |
HK (1) | HK1011182A1 (de) |
HU (1) | HUP9901205A3 (de) |
IL (1) | IL124052A (de) |
NO (1) | NO320392B1 (de) |
PT (1) | PT869774E (de) |
SE (1) | SE505146C2 (de) |
WO (1) | WO1997014408A1 (de) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ503513A (en) * | 1997-09-18 | 2004-12-24 | Skyepharma Inc | Sustained-release liposomal anesthetic compositions |
US20070212422A1 (en) * | 1999-11-10 | 2007-09-13 | Manfred Keller | Dry powder for inhalation |
US6458387B1 (en) * | 1999-10-18 | 2002-10-01 | Epic Therapeutics, Inc. | Sustained release microspheres |
ES2169980B1 (es) | 1999-12-17 | 2003-11-01 | Lipotec Sa | Microcapsulas para la liberacion prolongada de farmacos. |
IT1318380B1 (it) * | 2000-03-09 | 2003-08-25 | Intercos Italiana | Polvere cosmetica rivestita. |
US6495164B1 (en) | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
ATE401095T1 (de) * | 2000-05-26 | 2008-08-15 | Frohwitter Bernhard | Mittel zum erhalten und/oder korrigieren der blutglukosekonzentration |
US6824822B2 (en) * | 2001-08-31 | 2004-11-30 | Alkermes Controlled Therapeutics Inc. Ii | Residual solvent extraction method and microparticles produced thereby |
SE517422C2 (sv) | 2000-10-06 | 2002-06-04 | Bioglan Ab | Farmaceutiskt acceptabel stärkelse |
AU2001294459A1 (en) | 2000-10-06 | 2002-04-15 | Jagotec Ag | A controlled-release, parenterally administrable microparticle preparation |
SE517421C2 (sv) | 2000-10-06 | 2002-06-04 | Bioglan Ab | Mikropartiklar, lämpade för parenteral administration, väsentligen bestående av stärkelse med minst 85 % amylopektin och med reducerad molekylvikt, samt framställning därav |
ES2326209T3 (es) | 2000-10-27 | 2009-10-05 | Baxter Healthcare S.A. | Produccion de microesferas. |
SE518007C2 (sv) | 2000-11-16 | 2002-08-13 | Bioglan Ab | Förfarande för framställning av mikropartiklar |
US7034037B2 (en) | 2001-06-29 | 2006-04-25 | Ethicon, Inc. | Compositions and medical devices utilizing bioabsorbable polymeric waxes and rapamycin |
US6967234B2 (en) * | 2002-12-18 | 2005-11-22 | Ethicon, Inc. | Alkyd-lactone copolymers for medical applications |
US7030127B2 (en) * | 2001-06-29 | 2006-04-18 | Ethicon, Inc. | Composition and medical devices utilizing bioabsorbable polymeric waxes |
US20030064033A1 (en) * | 2001-08-16 | 2003-04-03 | Brown Larry R. | Propellant-based microparticle formulations |
US7105181B2 (en) | 2001-10-05 | 2006-09-12 | Jagotec, Ag | Microparticles |
CA2476556A1 (en) | 2002-02-13 | 2003-08-21 | Duke University | Modulation of immune response by non-peptide binding stress response polypeptides |
SE0201599D0 (sv) | 2002-03-21 | 2002-05-30 | Skyepharma Ab | Microparticles |
US7005136B2 (en) | 2002-03-29 | 2006-02-28 | Ethicon, Inc. | Bone replacement materials utilizing bioabsorbable liquid polymers |
US7326426B2 (en) * | 2002-03-29 | 2008-02-05 | Ethicon, Inc. | Compositions and medical devices utilizing bioabsorbable liquid polymers |
US7368125B2 (en) * | 2002-06-05 | 2008-05-06 | Ethicon, Inc. | Amphiphilic polymers for medical applications |
US7026374B2 (en) * | 2002-06-25 | 2006-04-11 | Aruna Nathan | Injectable microdispersions for medical applications |
US7101566B2 (en) * | 2002-06-28 | 2006-09-05 | Ethicon, Inc. | Polymer coated microparticles for sustained release |
EP1558282A4 (de) * | 2002-10-01 | 2006-04-19 | Chiron Corp | Zusammensetzungen gegen krebs und infektionskrankheiten und anwendungsverfahren dafür |
US6872799B2 (en) | 2002-12-18 | 2005-03-29 | Ethicon, Inc. | Functionalized polymers for medical applications |
US6866860B2 (en) | 2002-12-19 | 2005-03-15 | Ethicon, Inc. | Cationic alkyd polyesters for medical applications |
JP2006523613A (ja) * | 2002-12-20 | 2006-10-19 | エスティ.ジェイムス アソシエイト エルエルシー/フェイバー リサーチ シリーズ | 徐放性医薬投与のための被覆粒子 |
US20040120981A1 (en) * | 2002-12-20 | 2004-06-24 | Aruna Nathan | Crosslinked alkyd polyesters for medical applications |
US7060299B2 (en) * | 2002-12-31 | 2006-06-13 | Battelle Memorial Institute | Biodegradable microparticles that stabilize and control the release of proteins |
AU2004251457B2 (en) * | 2003-06-26 | 2010-09-23 | Mediolanum Pharmaceuticals Ltd. | Subcutaneous implants having limited initial release of the active principle and subsequent linearly varying extended release thereof |
TWI357815B (en) * | 2003-06-27 | 2012-02-11 | Euro Celtique Sa | Multiparticulates |
CA2532837A1 (en) * | 2003-07-18 | 2005-04-21 | Baxter International, Inc. | Method for preparing small spherical particles by controlled phase separation |
US20050142205A1 (en) * | 2003-07-18 | 2005-06-30 | Julia Rashba-Step | Methods for encapsulating small spherical particles prepared by controlled phase separation |
US20070092452A1 (en) * | 2003-07-18 | 2007-04-26 | Julia Rashba-Step | Methods for fabrication, uses, compositions of inhalable spherical particles |
US20050048127A1 (en) * | 2003-07-22 | 2005-03-03 | Larry Brown | Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof |
KR100453273B1 (ko) * | 2003-09-04 | 2004-10-15 | 주식회사 펩트론 | 초음파 이중공급노즐을 이용한 서방성 미립구의 제조 방법 |
US20060110423A1 (en) * | 2004-04-15 | 2006-05-25 | Wright Steven G | Polymer-based sustained release device |
MXPA06011924A (es) * | 2004-04-15 | 2007-06-11 | Alkermes Inc | Dispositivo de liberacion continua base polimeros. |
US7456254B2 (en) * | 2004-04-15 | 2008-11-25 | Alkermes, Inc. | Polymer-based sustained release device |
MXPA06012989A (es) * | 2004-05-12 | 2007-06-12 | Baxter Int | Microesferas de acidos nucleicos, produccion y suministro de las mismas. |
CA2566075A1 (en) | 2004-05-12 | 2005-12-01 | Baxter Healthcare S.A. | Microspheres comprising protein and showing injectability at high concentrations of said agent |
ATE409025T1 (de) | 2004-05-12 | 2008-10-15 | Baxter Int | Nukleinsäure-mikrokügelchen, ihre herstellung und abgabe |
US8728525B2 (en) | 2004-05-12 | 2014-05-20 | Baxter International Inc. | Protein microspheres retaining pharmacokinetic and pharmacodynamic properties |
US8173148B2 (en) * | 2004-11-10 | 2012-05-08 | Tolmar Therapeutics, Inc. | Stabilized polymeric delivery system comprising a water-insoluble polymer and an organic liquid |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
US8318210B2 (en) | 2005-02-28 | 2012-11-27 | Neos Therapeutics, Lp | Compositions and methods of making sustained release liquid formulations |
EP1885335A1 (de) * | 2005-04-27 | 2008-02-13 | BAXTER INTERNATIONAL INC. (a Delaware corporation) | Oberflächenmodifizierte mikroteilchen und verfahren zu ihrer bildung und verwendung |
US8017152B2 (en) | 2005-05-27 | 2011-09-13 | Stratosphere Pharma Ab | Cores and microcapsules suitable for parenteral administration as well as process for their manufacture |
EP1726299A3 (de) | 2005-05-27 | 2007-04-18 | StratoSphere Pharma AB | Kerne und Mikrokapsel zur parenteralen Verabreichung sowie Verfahren zu deren Herstellung |
JP2009507845A (ja) * | 2005-09-07 | 2009-02-26 | サウスウエスト リサーチ インスティテュート | 改良された放出速度を示す生分解性微粒子薬学的処方物 |
US9693967B2 (en) | 2005-09-07 | 2017-07-04 | Southwest Research Institute | Biodegradable microparticle pharmaceutical formulations exhibiting improved released rates |
US20070092553A1 (en) * | 2005-10-21 | 2007-04-26 | Pfab Lp | Compositions and methods of making rapidly dissolving lonically masked formulations |
US20080286375A1 (en) * | 2005-11-15 | 2008-11-20 | Amorepacific Corporation | Method for Preparing Sustained-Release Microparticles Comprising Sucrose Acetate Isobutyrate |
GB0602897D0 (en) * | 2006-02-13 | 2006-03-22 | Jagotec Ag | Improvements In Or Relating To Dry Powder Inhaler Devices |
US20070281031A1 (en) * | 2006-06-01 | 2007-12-06 | Guohan Yang | Microparticles and methods for production thereof |
EP2647712A3 (de) | 2006-08-04 | 2013-11-20 | Baxter International Inc | Zusammensetzung auf Mikrokügelchenbasis zur Vorbeugung und/oder Umkehrung einer Neuerkrankung an autoimmun bedingter Diabetes |
ES2422864T3 (es) | 2006-08-09 | 2013-09-16 | Intarcia Therapeutics, Inc | Sistemas de liberación osmótica y unidades de pistón |
AU2007319577A1 (en) * | 2006-10-06 | 2008-05-22 | Baxter Healthcare S.A. | Microencapsules containing surface-modified microparticles and methods of forming and using the same |
GB0622818D0 (en) * | 2006-11-15 | 2006-12-27 | Jagotec Ag | Improvements in or relating to organic compounds |
GB0625303D0 (en) * | 2006-12-19 | 2007-01-24 | Jagotec Ag | Improvements in and relating to metered dose inhalers |
JP2010522196A (ja) * | 2007-03-22 | 2010-07-01 | アルカームズ,インコーポレイテッド | コアセルベーション工程 |
GB0707612D0 (en) | 2007-04-19 | 2007-05-30 | Stratosphere Pharma Ab | Cores and microcapsules suitable for parenteral administration as well as process for their manufacture |
RU2440097C2 (ru) | 2007-04-23 | 2012-01-20 | Интарсия Терапьютикс, Инк. | Способ лечения диабета ii типа и ожирения, осмотическое устройство для доставки и способ его изготовления |
US8313770B2 (en) * | 2007-05-30 | 2012-11-20 | Neos Therapeutics, Lp | Modifying drug release in suspensions of ionic resin systems |
WO2008157540A1 (en) * | 2007-06-20 | 2008-12-24 | Alkermes, Inc. | Quench liquids and washing systems for production of microparticles |
EP2240155B1 (de) | 2008-02-13 | 2012-06-06 | Intarcia Therapeutics, Inc | Vorrichtungen, formulierungen und verfahren zur freisetzung mehrerer wirkstoffe |
US8367427B2 (en) | 2008-08-20 | 2013-02-05 | Baxter International Inc. | Methods of processing compositions containing microparticles |
US8323615B2 (en) | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing multi-phasic dispersions |
US8323685B2 (en) | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing compositions containing microparticles |
EP3323423B1 (de) | 2009-09-28 | 2020-06-17 | Intarcia Therapeutics, Inc | Schnelle initiierung und/oder beendigung der verabreichung substantiell stabiler arzneimittel |
KR101331136B1 (ko) | 2011-01-12 | 2013-11-26 | 아주대학교산학협력단 | 약물의 초기 과다 방출 제어를 위한 약물전달 제형 및 이의 제조방법 |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
EP3981388A1 (de) | 2013-03-21 | 2022-04-13 | Eupraxia Pharmaceuticals USA LLC | Injizierbare zusammensetzung mit verzögerter freisetzung und verfahren zur verwendung für die behandlung von entzündungen in gelenken und damit einhergehendem schmerz |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
EP3302354B1 (de) | 2015-06-03 | 2023-10-04 | i2o Therapeutics, Inc. | Systeme zum einsetzen eines implantats |
PT3206672T (pt) | 2015-10-27 | 2018-06-20 | Eupraxia Pharmaceuticals Inc | Formulações de libertação prolongada de anestésicos locais |
WO2017200943A1 (en) | 2016-05-16 | 2017-11-23 | Intarcia Therapeutics, Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
KR20190104039A (ko) | 2017-01-03 | 2019-09-05 | 인타르시아 세라퓨틱스 인코포레이티드 | Glp-1 수용체 효능제의 연속적인 투여 및 약물의 동시-투여를 포함하는 방법 |
KR102383448B1 (ko) * | 2020-04-20 | 2022-04-06 | 한국화학연구원 | 락트산 또는 글리콜산을 포함하는 미립구형 서방출 제제 및 그의 제조방법 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3117027A (en) * | 1960-01-08 | 1964-01-07 | Wisconsin Alumni Res Found | Apparatus for coating particles in a fluidized bed |
US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4384975A (en) * | 1980-06-13 | 1983-05-24 | Sandoz, Inc. | Process for preparation of microspheres |
US4479911A (en) * | 1982-01-28 | 1984-10-30 | Sandoz, Inc. | Process for preparation of microspheres and modification of release rate of core material |
US4637905A (en) * | 1982-03-04 | 1987-01-20 | Batelle Development Corporation | Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or ε-caprolactones |
CH661206A5 (fr) * | 1983-09-23 | 1987-07-15 | Debiopharm Sa | Procede pour la preparation d'un medicament destine au traitement de maladies hormonodependantes. |
US4568559A (en) * | 1984-02-06 | 1986-02-04 | Biotek, Inc. | Composite core coated microparticles and process of preparing same |
US4623588A (en) * | 1984-02-06 | 1986-11-18 | Biotek, Inc. | Controlled release composite core coated microparticles |
CA1256638A (en) * | 1984-07-06 | 1989-06-27 | Motoaki Tanaka | Polymer and its production |
JP2551756B2 (ja) * | 1985-05-07 | 1996-11-06 | 武田薬品工業株式会社 | ポリオキシカルボン酸エステルおよびその製造法 |
US4666704A (en) * | 1985-05-24 | 1987-05-19 | International Minerals & Chemical Corp. | Controlled release delivery system for macromolecules |
SE459005B (sv) * | 1985-07-12 | 1989-05-29 | Aake Rikard Lindahl | Saett att framstaella sfaeriska polymerpartiklar |
JP2541835B2 (ja) * | 1986-04-07 | 1996-10-09 | ローヌ―プーラン ローラー インターナショナル(ホウルディングス) インコーポレイテッド | 持続放出型薬理組成物の製法およびこれにより得られる組成物 |
SE8701479L (sv) * | 1987-04-09 | 1988-10-10 | Carbomatrix Ab | Metod foer inneslutning av biologiskt verksamma preparat samt anvaendning daerav |
US5019397A (en) * | 1988-04-21 | 1991-05-28 | Alza Corporation | Aqueous emulsion for pharmaceutical dosage form |
US5275819A (en) * | 1989-02-06 | 1994-01-04 | Amer Particle Technologies Inc. | Drug loaded pollen grains with an outer coating for pulsed delivery |
US5019400A (en) * | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
JP2571874B2 (ja) * | 1989-11-06 | 1997-01-16 | アルカーメス コントロールド セラピューティクス,インコーポレイテッド | タンパク質マイクロスフェア組成物 |
FR2663207B1 (fr) * | 1990-06-15 | 1993-04-30 | Rhone Poulenc Nutrition Animal | Procede d'enrobage par un polymere ph sensible de principes actifs. |
EP0576675A4 (en) * | 1991-03-25 | 1994-06-01 | Fujisawa Pharmaceutical Co | Long-acting pharmaceutical preparation |
CA2079509C (en) * | 1991-10-01 | 2002-05-14 | Shigeyuki Takada | Prolonged release microparticle preparation and production of the same |
US5288502A (en) * | 1991-10-16 | 1994-02-22 | The University Of Texas System | Preparation and uses of multi-phase microspheres |
EP0674506B1 (de) * | 1992-12-02 | 2000-08-23 | Alkermes Controlled Therapeutics, Inc. | Wachstumhormon enthaltende mikrosphaeren mit kontrollierter freisetzung |
US5417982A (en) * | 1994-02-17 | 1995-05-23 | Modi; Pankaj | Controlled release of drugs or hormones in biodegradable polymer microspheres |
-
1995
- 1995-10-19 SE SE9503672A patent/SE505146C2/sv not_active IP Right Cessation
-
1996
- 1996-09-03 DE DE0869774T patent/DE869774T1/de active Pending
- 1996-09-03 IL IL12405296A patent/IL124052A/xx not_active IP Right Cessation
- 1996-09-03 EP EP06010350A patent/EP1716849A1/de not_active Withdrawn
- 1996-09-03 ES ES01117830T patent/ES2267637T3/es not_active Expired - Lifetime
- 1996-09-03 EP EP96935641A patent/EP0869774B1/de not_active Expired - Lifetime
- 1996-09-03 AU AU73478/96A patent/AU699080B2/en not_active Ceased
- 1996-09-03 DE DE69625240T patent/DE69625240T2/de not_active Expired - Fee Related
- 1996-09-03 DK DK96935641T patent/DK0869774T3/da active
- 1996-09-03 EP EP01117830A patent/EP1142569B1/de not_active Expired - Lifetime
- 1996-09-03 HU HU9901205A patent/HUP9901205A3/hu unknown
- 1996-09-03 ES ES96935641T patent/ES2125209T3/es not_active Expired - Lifetime
- 1996-09-03 AT AT96935641T patent/ATE228826T1/de not_active IP Right Cessation
- 1996-09-03 DE DE69636177T patent/DE69636177T2/de not_active Expired - Fee Related
- 1996-09-03 JP JP9515728A patent/JP2000501380A/ja active Pending
- 1996-09-03 KR KR1019980702757A patent/KR100482262B1/ko not_active IP Right Cessation
- 1996-09-03 AT AT01117830T patent/ATE326953T1/de not_active IP Right Cessation
- 1996-09-03 PT PT96935641T patent/PT869774E/pt unknown
- 1996-09-03 WO PCT/SE1996/001091 patent/WO1997014408A1/en active IP Right Grant
- 1996-09-03 US US09/051,709 patent/US6120787A/en not_active Expired - Fee Related
- 1996-09-03 CZ CZ19981173A patent/CZ293059B6/cs not_active IP Right Cessation
-
1998
- 1998-04-06 NO NO19981558A patent/NO320392B1/no unknown
- 1998-11-16 HK HK98112027A patent/HK1011182A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE869774T1 (de) | Partikel mit verzögerter freisetzung | |
CA2271889A1 (en) | Method of controlling release of caffeine in chewing gum and gum produced thereby | |
ATE134900T1 (de) | Verfahren zur herstellung von feinkugeligen, gleichförmig grossen anorganischen teilchen | |
KR860000067A (ko) | 고체다환식 약물의 용해도를 증진시키는 방법 | |
ATE255911T1 (de) | Verfahren zur herstellung von mikrokapseln | |
KR910018017A (ko) | 구형시드코어, 구형과립 및 그의 제조방법 | |
ES524518A0 (es) | Un procedimiento para preparar un agente anti-inflamatorio | |
JPS57164436A (en) | Manufacture of magnetic recording medium | |
FI906383A (fi) | Pao retikulerade polyorganosiloxan baserade magnetiserbara core-shell-mikrobollar, foerfarande foer framstaellning av dessa och anvaendning av desamma i biologi. | |
ES2152409T3 (es) | Encapsulado multiple de sustancias oleofilicas. | |
CA2146964A1 (en) | Particles having gelatin-aminodextran coatings of and processes for making same | |
ATE273140T1 (de) | Aufzeichnungsmaterial, herstellungsverfahren desgleichen und bebilderungsverfahren | |
ES257336A1 (es) | Metodo para la producciën de una preparaciën seca pulverulenta | |
FI906382A0 (fi) | Pao polysilseskvioxan baserade magnetiserbara mikrobollar, foerfarande foer framstaellning av dessa och anvaendning av desamma i biologi. | |
CA2234615A1 (en) | Sustained release particles | |
JPH03250063A (ja) | 芳香性塗料 | |
JPS59101865A (ja) | カラ−固体撮像素子の製造方法 | |
JPS5499373A (en) | Method of formation of fluorescent substance layer for bulb | |
JPS5689834A (en) | Production of microcapsule | |
KR930020372A (ko) | 자기기록 매체의 제조방법 | |
SE9000471D0 (sv) | Don foer torkning av luft med mikrovaagsenergi |