EP0764866A3 - Confocal microscope - Google Patents

Confocal microscope Download PDF

Info

Publication number
EP0764866A3
EP0764866A3 EP96116486A EP96116486A EP0764866A3 EP 0764866 A3 EP0764866 A3 EP 0764866A3 EP 96116486 A EP96116486 A EP 96116486A EP 96116486 A EP96116486 A EP 96116486A EP 0764866 A3 EP0764866 A3 EP 0764866A3
Authority
EP
European Patent Office
Prior art keywords
confocal microscope
confocal
microscope
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP96116486A
Other languages
German (de)
French (fr)
Other versions
EP0764866B1 (en
EP0764866B2 (en
EP0764866A2 (en
Inventor
Timothy Peter Dabbs
Martin Russell Harris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Optiscan Pty Ltd
Original Assignee
Optiscan Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3773252&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0764866(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Optiscan Pty Ltd filed Critical Optiscan Pty Ltd
Publication of EP0764866A2 publication Critical patent/EP0764866A2/en
Publication of EP0764866A3 publication Critical patent/EP0764866A3/en
Publication of EP0764866B1 publication Critical patent/EP0764866B1/en
Application granted granted Critical
Publication of EP0764866B2 publication Critical patent/EP0764866B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/02Objectives
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/002Scanning microscopes
    • G02B21/0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/002Scanning microscopes
    • G02B21/0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052Optical details of the image generation
    • G02B21/0068Optical details of the image generation arrangements using polarisation
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/18Arrangements with more than one light path, e.g. for comparing two specimens
EP96116486A 1988-08-01 1989-08-01 Confocal microscope Expired - Lifetime EP0764866B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AUPI958788 1988-08-01
AUPI958788 1988-08-01
AUPI9587/88 1988-08-01
EP19890908678 EP0427755A4 (en) 1988-08-01 1989-08-01 Confocal microscope

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP19890908678 Division EP0427755A4 (en) 1988-08-01 1989-08-01 Confocal microscope
EP89908678.9 Division 1990-02-28

Publications (4)

Publication Number Publication Date
EP0764866A2 EP0764866A2 (en) 1997-03-26
EP0764866A3 true EP0764866A3 (en) 1997-05-14
EP0764866B1 EP0764866B1 (en) 2000-11-08
EP0764866B2 EP0764866B2 (en) 2006-08-23

Family

ID=3773252

Family Applications (2)

Application Number Title Priority Date Filing Date
EP96116486A Expired - Lifetime EP0764866B2 (en) 1988-08-01 1989-08-01 Confocal microscope
EP19890908678 Ceased EP0427755A4 (en) 1988-08-01 1989-08-01 Confocal microscope

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP19890908678 Ceased EP0427755A4 (en) 1988-08-01 1989-08-01 Confocal microscope

Country Status (7)

Country Link
US (1) US5161053A (en)
EP (2) EP0764866B2 (en)
JP (1) JP3583125B2 (en)
AU (1) AU610430B2 (en)
CA (1) CA1325537C (en)
DE (1) DE68929262T3 (en)
WO (1) WO1990001716A1 (en)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE02012428T1 (en) * 1988-07-13 2005-12-15 Optiscan Pty. Ltd., Toorak Confocal scanning microscope
JP2792657B2 (en) * 1988-12-26 1998-09-03 浜松ホトニクス株式会社 Scanning optical microscope
EP0666487A2 (en) * 1989-09-22 1995-08-09 Fuji Photo Film Co., Ltd. Scanning microscope and scanning mechanism for the same
AU643787B2 (en) * 1990-04-06 1993-11-25 Optiscan Pty Limited Confocal microscope
ATE126903T1 (en) * 1990-04-06 1995-09-15 Martin Russell Harris CONFOCAL MICROSCOPE.
JPH05508707A (en) * 1990-04-23 1993-12-02 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガナイゼイション Interferometric measurement system and method
FR2661754B1 (en) * 1990-05-03 1994-03-11 Thomas Brunner PRINCIPLE AND SYSTEM OF HIGH RESOLUTION OPTICAL IMAGING WITH CORPUSCULAR EFFECT OF THE PHOTON AND SPATIO-TEMPORAL EFFECT.
IL94308A0 (en) * 1990-05-07 1991-03-10 Scitex Corp Ltd Laser scanning apparatus
CA2116874A1 (en) * 1991-09-06 1993-03-18 Christopher Joseph Cantrall Optical methods and apparatus
JP3018687B2 (en) * 1991-12-12 2000-03-13 松下電器産業株式会社 Scanning laser microscope
US5306902A (en) * 1992-09-01 1994-04-26 International Business Machines Corporation Confocal method and apparatus for focusing in projection lithography
US5430807A (en) * 1992-12-14 1995-07-04 Gravely Research Corporation Variable magnification color scanning light microscope
DE4446185C2 (en) * 1994-08-25 1997-03-27 Leica Lasertechnik Device for coupling a UV laser beam into a confocal laser scanning microscope
EP0734539B1 (en) * 1994-08-25 2002-11-13 Leica Microsystems Heidelberg GmbH Device for feeding the light beam from a uv laser into a laser scanning microscope
US5923465A (en) * 1994-10-28 1999-07-13 Marc J. Byrd System for scanning confocal image reconstruction from coherent recordings
US5726801A (en) * 1994-12-21 1998-03-10 E-Tek Dynamics, Inc. Reduced optical isolator module for a miniaturized laser diode assembly
US5557452A (en) * 1995-02-06 1996-09-17 University Of Hawaii Confocal microscope system
CA2215975A1 (en) * 1995-03-24 1996-10-03 Optiscan Pty. Ltd. Optical fibre confocal imager with variable near-confocal control
US5578818A (en) * 1995-05-10 1996-11-26 Molecular Dynamics LED point scanning system
US5785651A (en) * 1995-06-07 1998-07-28 Keravision, Inc. Distance measuring confocal microscope
US5713364A (en) * 1995-08-01 1998-02-03 Medispectra, Inc. Spectral volume microprobe analysis of materials
US6104945A (en) * 1995-08-01 2000-08-15 Medispectra, Inc. Spectral volume microprobe arrays
US5813987A (en) * 1995-08-01 1998-09-29 Medispectra, Inc. Spectral volume microprobe for analysis of materials
DE19744302B4 (en) * 1996-06-04 2008-04-17 Carl Zeiss Jena Gmbh Device for coupling the radiation of short-pulse lasers in a microscopic beam path
DE19622359B4 (en) * 1996-06-04 2007-11-22 Carl Zeiss Jena Gmbh Device for coupling the radiation of short-pulse lasers in a microscopic beam path
DE19654211C2 (en) * 1996-12-24 2000-07-06 Leica Microsystems Confocal microscope
US6826422B1 (en) 1997-01-13 2004-11-30 Medispectra, Inc. Spectral volume microprobe arrays
US6847490B1 (en) 1997-01-13 2005-01-25 Medispectra, Inc. Optical probe accessory device for use in vivo diagnostic procedures
US5995281A (en) * 1997-04-09 1999-11-30 Carl Zeiss Jena Gmbh Device for coupling the radiation of short-pulse lasers in an optical beam path of a microscope
US5887009A (en) * 1997-05-22 1999-03-23 Optical Biopsy Technologies, Inc. Confocal optical scanning system employing a fiber laser
US6967772B2 (en) * 1997-07-16 2005-11-22 Optiscan Pty Ltd Scanning microscope with miniature head
US6069698A (en) * 1997-08-28 2000-05-30 Olympus Optical Co., Ltd. Optical imaging apparatus which radiates a low coherence light beam onto a test object, receives optical information from light scattered by the object, and constructs therefrom a cross-sectional image of the object
US6327493B1 (en) 1997-08-28 2001-12-04 Olympus Optical Co., Ltd. Light scanning devices of a water-tight structure to be inserted into a body cavity to obtain optical information on inside of a biological tissue
US6411838B1 (en) 1998-12-23 2002-06-25 Medispectra, Inc. Systems and methods for optical examination of samples
WO2000036973A1 (en) 1998-12-23 2000-06-29 Medispectra, Inc. Optical methods and systems for cervical screening
US6181474B1 (en) 1999-03-22 2001-01-30 Kovex Corporation Scanning confocal microscope with objective lens position tracking
US6548796B1 (en) 1999-06-23 2003-04-15 Regents Of The University Of Minnesota Confocal macroscope
US6265945B1 (en) * 1999-10-25 2001-07-24 Kernco, Inc. Atomic frequency standard based upon coherent population trapping
US6545260B1 (en) 1999-11-19 2003-04-08 Olympus Optical Co., Ltd. Light scanning optical device which acquires a high resolution two-dimensional image without employing a charge-coupled device
DE20022966U1 (en) * 1999-12-02 2002-08-22 Evotec Ag High-throughput screening device for the optical detection of samples
US7187810B2 (en) 1999-12-15 2007-03-06 Medispectra, Inc. Methods and systems for correcting image misalignment
US7260248B2 (en) 1999-12-15 2007-08-21 Medispectra, Inc. Image processing using measures of similarity
US6902935B2 (en) 1999-12-15 2005-06-07 Medispectra, Inc. Methods of monitoring effects of chemical agents on a sample
US6429968B1 (en) 2000-03-09 2002-08-06 Agere Systems Guardian Corp Apparatus for photoluminescence microscopy and spectroscopy
US6462814B1 (en) * 2000-03-15 2002-10-08 Schlumberger Technologies, Inc. Beam delivery and imaging for optical probing of a device operating under electrical test
DE20122783U1 (en) * 2000-06-17 2007-11-15 Leica Microsystems Cms Gmbh Arrangement for examining microscopic specimens with a scanning microscope and illumination device for a scanning microscope
US6898367B2 (en) * 2000-06-17 2005-05-24 Leica Microsystems Heidelberg Gmbh Method and instrument for microscopy
DE50108370D1 (en) * 2000-06-17 2006-01-19 Leica Microsystems Arrangement for examining microscopic specimens with a scanning microscope
EP1164402B1 (en) * 2000-06-17 2010-04-28 Leica Microsystems CMS GmbH Scanning microscope with multiband illumination and optical element for a scanning microsscope with multiband illumination
DE10115590B4 (en) * 2000-06-17 2020-11-05 Leica Microsystems Cms Gmbh Scanning microscope
DE10035688B4 (en) * 2000-07-20 2004-07-22 Leica Microsystems Heidelberg Gmbh Optical arrangement
US6441356B1 (en) 2000-07-28 2002-08-27 Optical Biopsy Technologies Fiber-coupled, high-speed, angled-dual-axis optical coherence scanning microscopes
US6351325B1 (en) 2000-07-28 2002-02-26 Optical Biopsy Technologies, Inc. Fiber-coupled, angled-dual-axis confocal scanning microscopes for imaging in a scattering medium
US6423956B1 (en) * 2000-07-28 2002-07-23 Optical Biopsy Technologies Fiber-coupled, high-speed, integrated, angled-dual-axis confocal scanning microscopes employing vertical cross-section scanning
DE10044636A1 (en) * 2000-09-08 2002-03-21 Leica Microsystems Optical arrangement for illuminating objects for confocal scanning microscopes
US6369928B1 (en) 2000-11-01 2002-04-09 Optical Biopsy Technologies, Inc. Fiber-coupled, angled-dual-illumination-axis confocal scanning microscopes for performing reflective and two-photon fluorescence imaging
US7194118B1 (en) 2000-11-10 2007-03-20 Lucid, Inc. System for optically sectioning and mapping surgically excised tissue
US6414779B1 (en) 2000-11-30 2002-07-02 Opeical Biopsy Technologies, Inc. Integrated angled-dual-axis confocal scanning endoscopes
US6839661B2 (en) 2000-12-15 2005-01-04 Medispectra, Inc. System for normalizing spectra
US7151632B2 (en) * 2001-01-12 2006-12-19 University Of Rochester Apparatus for production of an inhomogeneously polarized optical beam for use in illumination and a method thereof
JP2002257932A (en) * 2001-03-06 2002-09-11 Nippon Telegr & Teleph Corp <Ntt> Imaging device of type detecting reflected electromagnetic wave
US7309867B2 (en) 2003-04-18 2007-12-18 Medispectra, Inc. Methods and apparatus for characterization of tissue samples
US6933154B2 (en) 2002-07-09 2005-08-23 Medispectra, Inc. Optimal windows for obtaining optical data for characterization of tissue samples
US7282723B2 (en) 2002-07-09 2007-10-16 Medispectra, Inc. Methods and apparatus for processing spectral data for use in tissue characterization
US7136518B2 (en) 2003-04-18 2006-11-14 Medispectra, Inc. Methods and apparatus for displaying diagnostic data
US7459696B2 (en) 2003-04-18 2008-12-02 Schomacker Kevin T Methods and apparatus for calibrating spectral data
US6818903B2 (en) * 2002-07-09 2004-11-16 Medispectra, Inc. Method and apparatus for identifying spectral artifacts
US7469160B2 (en) 2003-04-18 2008-12-23 Banks Perry S Methods and apparatus for evaluating image focus
US6768918B2 (en) 2002-07-10 2004-07-27 Medispectra, Inc. Fluorescent fiberoptic probe for tissue health discrimination and method of use thereof
US7103401B2 (en) 2002-07-10 2006-09-05 Medispectra, Inc. Colonic polyp discrimination by tissue fluorescence and fiberoptic probe
US7252634B2 (en) * 2002-11-05 2007-08-07 Pentax Corporation Confocal probe having scanning mirrors mounted to a transparent substrate in an optical path of the probe
JP4603816B2 (en) 2003-05-16 2010-12-22 オプティスキャン ピーティーワイ リミテッド Optical connector
DE602004031941D1 (en) * 2003-05-30 2011-05-05 Olympus Co MEASURING DEVICE COMPRISING A LIGHT RECORDING UNIT
JP2005049219A (en) * 2003-07-29 2005-02-24 Toudai Tlo Ltd Scanning probe microscope
DE10335466B4 (en) * 2003-08-02 2005-09-01 Leica Microsystems Heidelberg Gmbh scanning microscope
US7338439B2 (en) * 2003-09-05 2008-03-04 Pentax Corporation Condensing optical system, confocal optical system, and scanning confocal endoscope
KR100602915B1 (en) 2004-07-03 2006-07-19 한국과학기술원 Apparatus and Method for Autofocus of Optical Microscopes by Confocal Principle
JP2008521516A (en) 2004-11-29 2008-06-26 ザ ジェネラル ホスピタル コーポレイション Configuration, apparatus, endoscope, catheter, and method for performing optical image generation by simultaneously illuminating and detecting multiple points on a sample
US7346233B2 (en) * 2005-02-14 2008-03-18 Corning Incorporated Single mode (SM) fiber optical reader system and method for interrogating resonant waveguide-grating sensor(s)
US8456738B2 (en) * 2005-04-14 2013-06-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Ultrahigh-resolution fiber-optic confocal microscope and method
GB0621585D0 (en) * 2006-10-30 2006-12-06 Secretary Trade Ind Brit Confocal microscope
GB2451442B (en) * 2007-07-30 2013-03-06 Lein Applied Diagnostics Ltd Optical measurement apparatus and method therefor
DE102007060966A1 (en) * 2007-12-14 2009-06-18 Hochschule Offenburg Optical measurement performing device, has fiber displaced by displacing device relative to element, where section of fiber is led to receiver and coupled with section based on source by coupling mechanism
US8982918B2 (en) * 2008-01-31 2015-03-17 Nkt Photonics A/S System, device and method for stabilizing the optical output power of an optical system
WO2010011953A1 (en) * 2008-07-25 2010-01-28 Sloan Kettering Institute For Cancer Research Rapid confocal microscopy to support surgical procedures
CH703111A1 (en) * 2010-05-07 2011-11-15 Suisse Electronique Microtech Device for enabling double passage of laser beam into gas cell of coherent-population-trapping atomic clock, has polarizer arranged between output of laser beam and splitter to protect laser diode from retro reflections emitted by elements
US8670178B2 (en) 2009-12-08 2014-03-11 Spectral Applied Research Inc. Imaging distal end of multimode fiber
US9557574B2 (en) * 2010-06-08 2017-01-31 Microsoft Technology Licensing, Llc Depth illumination and detection optics
EP2875394A1 (en) 2012-07-17 2015-05-27 Ecole Polytechnique Fédérale de Lausanne (EPFL) Reflective optical objective
US9564291B1 (en) * 2014-01-27 2017-02-07 Mochii, Inc. Hybrid charged-particle beam and light beam microscopy
JP2017513211A (en) 2014-02-28 2017-05-25 イムラ アメリカ インコーポレイテッド Generation and emission of multiwavelength ultrashort pulses applied to microscopes
WO2016110971A1 (en) * 2015-01-07 2016-07-14 オリンパス株式会社 Objective lens unit for photoacoustic microscope and photoacoustic microscope having same
EP3278166A2 (en) 2015-03-31 2018-02-07 Samantree Medical SA Systems and methods for in-operating-theatre imaging of fresh tissue resected during surgery for pathology assessment
DE102016203671A1 (en) * 2016-03-07 2017-09-07 Carl Zeiss Microscopy Gmbh Method for determining a height information of a sample and a scanning microscope
US10539776B2 (en) 2017-10-31 2020-01-21 Samantree Medical Sa Imaging systems with micro optical element arrays and methods of specimen imaging
US11747603B2 (en) 2017-10-31 2023-09-05 Samantree Medical Sa Imaging systems with micro optical element arrays and methods of specimen imaging
US10928621B2 (en) 2017-10-31 2021-02-23 Samantree Medical Sa Sample dishes for use in microscopy and methods of their use
CN114008708B (en) * 2019-06-24 2024-03-22 弗里奥光电有限公司 System and method for increasing data rate and storage density in three-dimensional optical data storage media

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500204A (en) * 1981-04-21 1985-02-19 Agency Of Industrial Science & Technology Scanning-type lithographic and image-pickup device using optical fiber
US4634880A (en) * 1982-04-19 1987-01-06 Siscan Systems, Inc. Confocal optical imaging system with improved signal-to-noise ratio
EP0283256A2 (en) * 1987-03-18 1988-09-21 Tektronix Inc. Scanning optical microscope
WO1990000754A1 (en) * 1988-07-13 1990-01-25 Martin Russell Harris Scanning confocal microscope

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3013467A (en) * 1957-11-07 1961-12-19 Minsky Marvin Microscopy apparatus
CH600301A5 (en) * 1976-05-28 1978-06-15 Bbc Brown Boveri & Cie
GB2038017B (en) * 1978-12-20 1982-11-24 Standard Telephones Cables Ltd Optical fibre directional coupler
DE2936463A1 (en) * 1979-09-10 1981-03-19 Siemens AG, 1000 Berlin und 8000 München DEVICE FOR GENERATING MOVING LIGHT BEAMS
USRE32660E (en) * 1982-04-19 1988-05-03 Siscan Systems, Inc. Confocal optical imaging system with improved signal-to-noise ratio
US4481418A (en) * 1982-09-30 1984-11-06 Vanzetti Systems, Inc. Fiber optic scanning system for laser/thermal inspection
JPS6098352A (en) * 1983-11-02 1985-06-01 Olympus Optical Co Ltd Ultrasonic microscope
GB8524742D0 (en) * 1985-10-08 1985-11-13 Iravani M V Fibre optic scanning systems
JPS62211503A (en) * 1986-03-13 1987-09-17 Hitachi Ltd Step measuring instrument
US5022743A (en) * 1987-03-27 1991-06-11 The Board Of Trustees Of The Leland Stanford Junior University Scanning confocal optical microscope
DE3853475T2 (en) * 1987-09-24 1995-09-14 Univ Washington CONCEPT AND CONVERSION SET OF A STANDARD MICROSCOPE INTO A MICROSCOPE WITH A COMMON FOCAL POINT AND EPI LIGHTING WITH SINGLE OPENING.
US5032720A (en) * 1988-04-21 1991-07-16 White John G Confocal imaging system
US5020891A (en) * 1988-09-14 1991-06-04 Washington University Single aperture confocal scanning biomicroscope and kit for converting single lamp biomicroscope thereto
US5004321A (en) * 1989-07-28 1991-04-02 At&T Bell Laboratories Resolution confocal microscope, and device fabrication method using same
US5035476A (en) * 1990-06-15 1991-07-30 Hamamatsu Photonics K.K. Confocal laser scanning transmission microscope

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500204A (en) * 1981-04-21 1985-02-19 Agency Of Industrial Science & Technology Scanning-type lithographic and image-pickup device using optical fiber
US4634880A (en) * 1982-04-19 1987-01-06 Siscan Systems, Inc. Confocal optical imaging system with improved signal-to-noise ratio
EP0283256A2 (en) * 1987-03-18 1988-09-21 Tektronix Inc. Scanning optical microscope
WO1990000754A1 (en) * 1988-07-13 1990-01-25 Martin Russell Harris Scanning confocal microscope

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
S.KIMURA ET AL.: "Confocal scanning optical microscope using single-mode fiber for signal detection", APPLIED OPTICS, vol. 30, no. 16, June 1991 (1991-06-01), NEW YORK,US, pages 2143 - 2150, XP000206274 *

Also Published As

Publication number Publication date
EP0764866B1 (en) 2000-11-08
US5161053A (en) 1992-11-03
EP0764866B2 (en) 2006-08-23
EP0764866A2 (en) 1997-03-26
AU610430B2 (en) 1991-05-16
DE68929262T3 (en) 2007-03-29
EP0427755A1 (en) 1991-05-22
EP0427755A4 (en) 1991-07-31
WO1990001716A1 (en) 1990-02-22
CA1325537C (en) 1993-12-28
DE68929262D1 (en) 2000-12-14
JP3583125B2 (en) 2004-10-27
JPH04500129A (en) 1992-01-09
AU3985489A (en) 1990-03-05
DE68929262T2 (en) 2001-05-31

Similar Documents

Publication Publication Date Title
EP0427755A4 (en) Confocal microscope
GB8830039D0 (en) Raman microscope
EP0339582A3 (en) Fluorescence microscope system
GB2184321B (en) Confocal scanning microscope
GB2193859B (en) Microscopes
EP0245089A3 (en) Microscope
EP0310514A3 (en) Binocular microscope
GB9017725D0 (en) Microscope
GB8712020D0 (en) Microscopes
GB2224575B (en) Electromagnetic microscope
GB2231681B (en) Optical microscopes
GB8822668D0 (en) Microscope
GB8801310D0 (en) Scanning optical microscopes
GB8816162D0 (en) Simple microscopes
GB9026197D0 (en) Microscopes
AU617289B3 (en) Confocal microscope
GB2212943B (en) Microscopes
GB2194115B (en) Microscopy
PL307306A1 (en) Toolroom microscope
GB2229548B (en) Microscope
GB2224363B (en) Hand microscope
GB8913788D0 (en) Microscope
GB8917656D0 (en) Microscope
GB9027502D0 (en) Microscope
GB8705870D0 (en) Hand microscope

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AC Divisional application: reference to earlier application

Ref document number: 427755

Country of ref document: EP

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): DE FR GB IT

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

RBV Designated contracting states (corrected)

Designated state(s): DE FR GB IT

17P Request for examination filed

Effective date: 19971031

TPAD Observations filed by third parties

Free format text: ORIGINAL CODE: EPIDOS TIPA

17Q First examination report despatched

Effective date: 19990520

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AC Divisional application: reference to earlier application

Ref document number: 427755

Country of ref document: EP

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): DE FR GB IT

REF Corresponds to:

Ref document number: 68929262

Country of ref document: DE

Date of ref document: 20001214

ET Fr: translation filed
ITF It: translation for a ep patent filed

Owner name: MITTLER & C. S.R.L.

PLBQ Unpublished change to opponent data

Free format text: ORIGINAL CODE: EPIDOS OPPO

PLBI Opposition filed

Free format text: ORIGINAL CODE: 0009260

PLBF Reply of patent proprietor to notice(s) of opposition

Free format text: ORIGINAL CODE: EPIDOS OBSO

26 Opposition filed

Opponent name: CARL ZEISS JENA GMBH

Effective date: 20010808

Opponent name: LANGE WILHELM

Effective date: 20010808

REG Reference to a national code

Ref country code: GB

Ref legal event code: IF02

PLBF Reply of patent proprietor to notice(s) of opposition

Free format text: ORIGINAL CODE: EPIDOS OBSO

PLBF Reply of patent proprietor to notice(s) of opposition

Free format text: ORIGINAL CODE: EPIDOS OBSO

RDAH Patent revoked

Free format text: ORIGINAL CODE: EPIDOS REVO

APAC Appeal dossier modified

Free format text: ORIGINAL CODE: EPIDOS NOAPO

APAC Appeal dossier modified

Free format text: ORIGINAL CODE: EPIDOS NOAPO

APAC Appeal dossier modified

Free format text: ORIGINAL CODE: EPIDOS NOAPO

APAA Appeal reference recorded

Free format text: ORIGINAL CODE: EPIDOS REFN

APBU Appeal procedure closed

Free format text: ORIGINAL CODE: EPIDOSNNOA9O

APAH Appeal reference modified

Free format text: ORIGINAL CODE: EPIDOSCREFNO

PUAH Patent maintained in amended form

Free format text: ORIGINAL CODE: 0009272

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: PATENT MAINTAINED AS AMENDED

27A Patent maintained in amended form

Effective date: 20060823

AK Designated contracting states

Kind code of ref document: B2

Designated state(s): DE FR GB IT

ET3 Fr: translation filed ** decision concerning opposition
PLAB Opposition data, opponent's data or that of the opponent's representative modified

Free format text: ORIGINAL CODE: 0009299OPPO

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20080814

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20080827

Year of fee payment: 20

Ref country code: FR

Payment date: 20080818

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20080813

Year of fee payment: 20

REG Reference to a national code

Ref country code: GB

Ref legal event code: PE20

Expiry date: 20090731

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20090731