EP0814827A4 - Vascular endothelial growth factor-b - Google Patents

Vascular endothelial growth factor-b

Info

Publication number
EP0814827A4
EP0814827A4 EP96909573A EP96909573A EP0814827A4 EP 0814827 A4 EP0814827 A4 EP 0814827A4 EP 96909573 A EP96909573 A EP 96909573A EP 96909573 A EP96909573 A EP 96909573A EP 0814827 A4 EP0814827 A4 EP 0814827A4
Authority
EP
European Patent Office
Prior art keywords
vascular endothelial
polypeptides
growth factor
endothelial growth
vegf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP96909573A
Other languages
German (de)
French (fr)
Other versions
EP0814827A1 (en
EP0814827B1 (en
Inventor
Ulf Eriksson
Birgitta Olofsson
Kari Alitalo
Katri Pajusola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Licentia Oy
Ludwig Institute for Cancer Research New York
Original Assignee
Ludwig Institute for Cancer Research Ltd
Helsinki University Licensing Ltd
Ludwig Institute for Cancer Research New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27410265&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0814827(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/469,427 external-priority patent/US5607918A/en
Application filed by Ludwig Institute for Cancer Research Ltd, Helsinki University Licensing Ltd, Ludwig Institute for Cancer Research New York filed Critical Ludwig Institute for Cancer Research Ltd
Publication of EP0814827A1 publication Critical patent/EP0814827A1/en
Publication of EP0814827A4 publication Critical patent/EP0814827A4/en
Application granted granted Critical
Publication of EP0814827B1 publication Critical patent/EP0814827B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides, pharmaceutical compositions containing them and antibodies which react with them. The VEGF-B polypeptides are useful in stimulating angiogenesis as well as in diagnostic applications.
EP96909573A 1995-03-01 1996-03-01 Vascular endothelial growth factor-b Expired - Lifetime EP0814827B1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US569063 1990-08-17
US39765195A 1995-03-01 1995-03-01
US397651 1995-03-01
US469427 1995-06-06
US08/469,427 US5607918A (en) 1995-03-01 1995-06-06 Vascular endothelial growth factor-B and DNA coding therefor
US08/569,063 US5928939A (en) 1995-03-01 1995-12-06 Vascular endothelial growth factor-b and dna coding therefor
PCT/US1996/002957 WO1996026736A1 (en) 1995-03-01 1996-03-01 Vascular endothelial growth factor-b

Publications (3)

Publication Number Publication Date
EP0814827A1 EP0814827A1 (en) 1998-01-07
EP0814827A4 true EP0814827A4 (en) 1999-11-10
EP0814827B1 EP0814827B1 (en) 2003-07-23

Family

ID=27410265

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96909573A Expired - Lifetime EP0814827B1 (en) 1995-03-01 1996-03-01 Vascular endothelial growth factor-b

Country Status (15)

Country Link
US (5) US5928939A (en)
EP (1) EP0814827B1 (en)
JP (2) JP3275024B2 (en)
CN (1) CN1146440C (en)
AT (1) ATE245437T1 (en)
AU (1) AU741856B2 (en)
CA (1) CA2211687C (en)
DE (1) DE69629181T2 (en)
DK (1) DK0814827T3 (en)
ES (1) ES2202432T3 (en)
HK (1) HK1008485A1 (en)
NO (1) NO973933L (en)
NZ (1) NZ305091A (en)
PT (1) PT814827E (en)
WO (1) WO1996026736A1 (en)

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7109308B1 (en) * 1994-03-08 2006-09-19 Human Genome Sciences, Inc. Antibodies to human vascular endothelial growth factor 2
US6608182B1 (en) 1994-03-08 2003-08-19 Human Genome Sciences, Inc. Human vascular endothelial growth factor 2
US6734285B2 (en) * 1994-03-08 2004-05-11 Human Genome Sciences, Inc. Vascular endothelial growth factor 2 proteins and compositions
US6040157A (en) * 1994-03-08 2000-03-21 Human Genome Sciences, Inc. Vascular endothelial growth factor 2
DK0751992T3 (en) * 1994-03-08 2006-03-06 Human Genome Sciences Inc Karendothelial growth factor 2
US5932540A (en) 1994-03-08 1999-08-03 Human Genome Sciences, Inc. Vascular endothelial growth factor 2
US7153827B1 (en) 1994-03-08 2006-12-26 Human Genome Sciences, Inc. Vascular endothelial growth factor 2 and methods of use
US7186688B1 (en) * 1994-03-08 2007-03-06 Human Genome Sciences, Inc. Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2
US5928939A (en) * 1995-03-01 1999-07-27 Ludwig Institute For Cancer Research Vascular endothelial growth factor-b and dna coding therefor
US7160991B1 (en) 1995-03-02 2007-01-09 Ludwig Institute For Cancer Research Vascular endothelial growth factor polypeptides
DE69630442T2 (en) * 1995-03-02 2004-08-19 Amrad Operations Pty. Ltd., Richmond A NEW GROWTH FACTOR AND A GENETIC SEQUENCE THAT CODES FOR THIS
US7429646B1 (en) 1995-06-05 2008-09-30 Human Genome Sciences, Inc. Antibodies to human tumor necrosis factor receptor-like 2
EP0873348A4 (en) * 1995-06-06 2000-11-08 Human Genome Sciences Inc Human vascular endothelial growth factor 3
US7423125B2 (en) * 1995-08-01 2008-09-09 Vegenics Limited Antibodies to VEGF-C
AU710696C (en) 1995-09-08 2002-10-24 Genentech Inc. VEGF-related protein
ES2341864T3 (en) 1995-09-29 2010-06-29 Universita Degli Studi Di Siena REGULATED GENES AND USES OF THE SAME.
US6994989B1 (en) 1995-11-08 2006-02-07 Immunex Corp. FLK-1 binding proteins
AU1116297A (en) 1995-11-08 1997-05-29 Immunex Corporation Flk-1 binding protein
US7357927B2 (en) 1996-03-12 2008-04-15 Human Genome Sciences, Inc. Death domain containing receptors
WO1997033904A1 (en) 1996-03-12 1997-09-18 Human Genome Sciences, Inc. Death domain containing receptors
US6713061B1 (en) 1996-03-12 2004-03-30 Human Genome Sciences, Inc. Death domain containing receptors
US6635743B1 (en) 1996-03-22 2003-10-21 Human Genome Sciences, Inc. Apoptosis inducing molecule II and methods of use
US7964190B2 (en) 1996-03-22 2011-06-21 Human Genome Sciences, Inc. Methods and compositions for decreasing T-cell activity
ATE306546T1 (en) 1996-08-23 2005-10-15 Ludwig Inst Cancer Res RECOMBINANT VASCULAR ENDOTHELIAL CELL GROWTH FACTOR D (VEGF-D)
WO1998024811A2 (en) * 1996-12-06 1998-06-11 Zymogenetics, Inc. Vascular endothelial growth factor
EP0960334A1 (en) * 1996-12-20 1999-12-01 Ludwig Institute For Cancer Research Vegf-b/receptor complex and uses thereof
ATE296117T1 (en) 1997-03-07 2005-06-15 Wistar Inst USE OF ADENOVIRAL VECTORS EXPRESSING PDGF OR VEGF TO HEAL TISSUE DEFECTS AND TO INDUCE HYPERVASCULISM IN MAMMAL TISSUES
IL132537A0 (en) * 1997-04-25 2001-03-19 Collateral Therapeutics Truncated vegf-related proteins
US6281175B1 (en) 1997-09-23 2001-08-28 Scimed Life Systems, Inc. Medical emulsion for lubrication and delivery of drugs
IL137616A0 (en) 1998-02-06 2001-07-24 Collateral Therapeutics Inc Variants of vegf-a
US20030118567A1 (en) * 1999-03-26 2003-06-26 Stewart Duncan John Cell-based therapy for the pulmonary system
DE19813774A1 (en) * 1998-03-27 1999-09-30 Max Planck Gesellschaft Parapox virus-encoded vascular endothelial cell growth factor (PPV-VEGF)
ATE556090T1 (en) 1998-11-10 2012-05-15 Ludwig Inst Cancer Res SHORTENED PLATELE-DERIVED GROWTH FACTOR D, DNA CODING IT AND THEIR USE
US6783953B1 (en) 1998-12-22 2004-08-31 Janssen Pharmaceutica N.V. Vascular endothelial growth factor-X
WO2000044903A1 (en) * 1999-01-29 2000-08-03 Ludwig Institute For Cancer Research Platelet-derived growth factor/vascular endothelial growth factor-like growth factor h, and uses thereof
US7223724B1 (en) 1999-02-08 2007-05-29 Human Genome Sciences, Inc. Use of vascular endothelial growth factor to treat photoreceptor cells
EP2357192A1 (en) 1999-02-26 2011-08-17 Human Genome Sciences, Inc. Human endokine alpha and methods of use
NZ513780A (en) * 1999-03-03 2001-09-28 Ludwig Inst Cancer Res Heart abnormalities in vascular endothelial growth factor B (VEGF-B) deficient animals and methods relating to these heart abnormalities
WO2000064261A1 (en) * 1999-04-26 2000-11-02 Ludwig Institute For Cancer Research Role of vascular endothelial growth factor-b (vegf-b) in developing bones and uses thereof
CA2375617A1 (en) * 1999-06-07 2000-12-14 Edwards Lifesciences Corporation Targeted angiogenesis
DE60040293D1 (en) * 1999-07-28 2008-10-30 Univ R USE OF NICOTIN IN THE ANGIOGENESIS AND THE VASCULOSIS
US8188043B2 (en) * 1999-07-28 2012-05-29 The Board Of Trustees Of The Leland Stanford Jr. University Nicotine in therapeutic angiogenesis and vasculogenesis
WO2001056602A2 (en) * 2000-02-02 2001-08-09 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cd40 ligand adjuvant for respiratory syncytial virus
AUPQ568100A0 (en) * 2000-02-16 2000-03-09 Amrad Operations Pty. Limited A method for producing recombinant molecules
AU3988401A (en) * 2000-02-25 2001-09-03 Ludwig Inst Cancer Res Materials and methods involving hybrid vascular endothelial growth factor dnas and proteins
AUPQ592100A0 (en) * 2000-02-29 2000-03-23 Council Of The Queensland Institute Of Medical Research, The A method of treatment and prophylaxis
US20030104977A1 (en) * 2000-03-31 2003-06-05 Ugo Ripamonti Methods for inducing angiogenesis using morphogenic proteins and stimulatory factors
CA2747325A1 (en) 2000-04-12 2001-10-25 Human Genome Sciences, Inc. Albumin fusion proteins
KR20030021159A (en) * 2000-05-17 2003-03-12 루드빅 인스티튜트 포 캔서 리서치 Methods for detecting for the presence of tumor cells and for screening for anti-tumor agents
WO2002007514A2 (en) * 2000-07-26 2002-01-31 Ludwig Institute Of Cancer Research Glycosylated vegf-b and method for increasing the amount of soluble vegf-b
WO2002011769A1 (en) * 2000-08-04 2002-02-14 Human Genome Sciences, Inc. Vascular endothelial growth factor 2
AU2001296521A1 (en) * 2000-10-02 2002-04-15 St. Elizabeth's Medical Center Of Boston, Inc. Use of lymphangiogenic agents to treat lymphatic disorders
WO2002036131A1 (en) * 2000-11-01 2002-05-10 Ludwig Institute For Cancer Research In vivo stimulation of angiogenic activity
US7026462B2 (en) * 2000-12-07 2006-04-11 Sangamo Biosciences, Inc. Regulation of angiogenesis with zinc finger proteins
US7067317B2 (en) * 2000-12-07 2006-06-27 Sangamo Biosciences, Inc. Regulation of angiogenesis with zinc finger proteins
US7611711B2 (en) 2001-01-17 2009-11-03 Vegenics Limited VEGFR-3 inhibitor materials and methods
US20070111944A1 (en) * 2001-02-16 2007-05-17 Scrofani Sergio D B Purification of vascular endothelial growth factor-B
US20070050857A1 (en) * 2001-02-28 2007-03-01 Hayward Nick K Method of treatment and prophylaxis
WO2002081639A2 (en) * 2001-04-06 2002-10-17 Georgetown University Gene brcc2 and diagnostic and therapeutic uses thereof
US7402312B2 (en) * 2001-04-13 2008-07-22 Human Genome Sciences, Inc. Antibodies to vascular endothelial growth factor 2 (VEGF-2)
DE60236646D1 (en) * 2001-04-13 2010-07-22 Human Genome Sciences Inc Anti-VEGF-2 antibodies
WO2002083849A2 (en) * 2001-04-13 2002-10-24 Human Genome Sciences, Inc. Vascular endothelial growth factor 2
AU2002256172A1 (en) * 2001-04-13 2002-10-28 Human Genome Sciences, Inc. Vascular endothelial growth factor 2
US20050232921A1 (en) * 2001-04-13 2005-10-20 Rosen Craig A Vascular endothelial growth factor 2
AU2002257794B8 (en) * 2001-04-24 2007-02-15 D. Collen Research Foundation Use of hypoxia inducible factor 2alpha for curing neonatal respiratory distress syndrome and as a target for the treatment of pulmonary hypertension
EP1581241A4 (en) * 2001-06-20 2005-11-09 Ludwig Inst Cancer Res Stimulation of vascularization with vegf-b
ATE477280T1 (en) * 2001-06-28 2010-08-15 Domantis Ltd DOUBLE-SPECIFIC LIGAND AND USE THEREOF
US20050271663A1 (en) * 2001-06-28 2005-12-08 Domantis Limited Compositions and methods for treating inflammatory disorders
WO2003006104A2 (en) * 2001-07-12 2003-01-23 Ludwig Institute For Cancer Research Lymphatic endothelial cells materials and methods
WO2003018752A2 (en) 2001-08-23 2003-03-06 The Wistar Institute Of Anatomy And Biology An organotypic intestinal culture and methods of use thereof
US20030113324A1 (en) * 2001-10-01 2003-06-19 Kari Alitalo Neuropilin/VEGF-C/VEGFR-3 materials and methods
US20040214766A1 (en) * 2001-10-01 2004-10-28 Kari Alitalo VEGF-C or VEGF-D materials and methods for treatment of neuropathologies
ES2425738T3 (en) 2001-12-21 2013-10-17 Human Genome Sciences, Inc. Albumin Fusion Proteins
US20030221931A1 (en) 2002-02-28 2003-12-04 Steve Marsh Sliding device
CA2429483A1 (en) * 2002-05-17 2003-11-17 Amrad Operations Pty Ltd. Immunointeractive molecules
EP1912069A3 (en) 2002-06-05 2008-07-09 Sopherion Therapeutics, Inc. Method to screen ligands using eukaryotic cell display
EP1514114A4 (en) * 2002-06-05 2007-03-21 Sopherion Therapeutics Inc Method to screen ligands using eukaryotic cell display
US20030232439A1 (en) * 2002-06-17 2003-12-18 Isis Pharmaceuticals Inc. Antisense modulation of VEGF-B expression
PT1517921E (en) * 2002-06-28 2006-09-29 Domantis Ltd DIFFERENTLY SPECIFIED LIGANDS WITH SEMI-LIFE IN THE INCREASED SERUM
US7696320B2 (en) 2004-08-24 2010-04-13 Domantis Limited Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
US9321832B2 (en) * 2002-06-28 2016-04-26 Domantis Limited Ligand
EP1545588A4 (en) 2002-07-23 2007-12-05 Ludwig Inst Cancer Res Methods and compositions for activating or inhibiting vegf-d and vegf-c
US7470538B2 (en) * 2002-12-05 2008-12-30 Case Western Reserve University Cell-based therapies for ischemia
EP1583422B1 (en) * 2002-12-05 2016-03-30 Case Western Reserve University Cell-based therapies for ischemia
JP2006523090A (en) * 2002-12-27 2006-10-12 ドマンティス リミテッド Bispecific single domain antibody specific for ligand and for ligand receptor
EP1594527A2 (en) * 2003-02-04 2005-11-16 Ludwig Institute For Cancer Research Vegf-b and pdgf modulation of stem cells
CN102813923B (en) 2003-08-27 2015-04-01 奥普索特克公司 Combination therapy for the treatment of ocular neovascular disorders
EP1560025A3 (en) * 2003-10-03 2011-09-07 F. Hoffmann-La Roche AG Specific markers for diabetes
JP2007517042A (en) 2003-12-30 2007-06-28 デュレクト コーポレーション Polymer implant for the controlled release of an active substance, preferably GNRH, preferably containing a mixture of PEG and PLG
WO2005084329A2 (en) * 2004-03-02 2005-09-15 Ludwig Institute For Cancer Research Method for inhibiting tumor formation and growth
WO2005087177A2 (en) * 2004-03-05 2005-09-22 Ludwig Institute For Cancer Research Chimeric anti-vegf-d antibodies and humanized anti-vegf-d antibodies and methods of using same
US20050282233A1 (en) * 2004-03-05 2005-12-22 Ludwig Institute For Cancer Research Multivalent antibody materials and methods for VEGF/PDGF family of growth factors
EP1732614B1 (en) * 2004-04-08 2008-12-24 Sangamo Biosciences Inc. Compositions for treating neuropathic and neurodegenerative conditions
JP5014130B2 (en) * 2004-08-02 2012-08-29 ズィナイス オペレーションズ ピーティーワイ．エルティーディー． Cancer treatment method comprising a VEGF-B antagonist
US7595149B1 (en) 2004-11-08 2009-09-29 University Of Kentucky Research Foundation Methods for cancer detection
ATE553122T1 (en) * 2005-02-28 2012-04-15 Sangamo Biosciences Inc ANTIANGIOGENIC METHODS AND COMPOSITIONS
US7893244B2 (en) * 2005-04-12 2011-02-22 Intradigm Corporation Composition and methods of RNAi therapeutics for treatment of cancer and other neovascularization diseases
SG161267A1 (en) * 2005-04-12 2010-05-27 Intradigm Corp Composition and methods of rnai therapeutics for treatment of cancer and other neovascularization diseases
EP1919944B1 (en) 2005-08-15 2011-03-23 Vegenics Pty Ltd Modified vegf and pdgf with improved angiogenic properties
CA2632866A1 (en) * 2005-12-01 2007-06-07 Domantis Limited Noncompetitive domain antibody formats that bind interleukin 1 receptor type 1
ES2497641T3 (en) 2006-05-17 2014-09-23 The Ludwig Institute For Cancer Research Direction to the regulation of VEGF-B of fatty acid transporters to modulate human diseases
WO2008085229A2 (en) * 2006-11-15 2008-07-17 Arteriocyte Inc. Cell-based therapies for treating liver disease
CA2683801A1 (en) * 2007-06-06 2008-12-11 Domantis Limited Polypeptides, antibody variable domains and antagonists
US7819579B2 (en) * 2007-11-26 2010-10-26 Schmulenson Harold K Radiation sensing device and holder
WO2009075565A1 (en) * 2007-12-12 2009-06-18 Erasmus University Medical Center Rotterdam Methods for controlling vasculogenesis
CA2710680C (en) 2007-12-26 2018-10-16 Vaccinex, Inc. Anti-c35 antibody combination therapies and methods
WO2009126698A2 (en) * 2008-04-09 2009-10-15 Ludwig Institute For Cancer Research Regulation of fatty acid transporters
IL205774A0 (en) * 2010-05-13 2010-12-30 Muhammad Abdulrazik Novel compounds for the treatment of glaucoma and ocular hypertension
KR101335203B1 (en) * 2010-03-26 2013-11-29 숙명여자대학교산학협력단 Peptides for Promotion of Angiogenesis and the use thereof
WO2011154308A1 (en) 2010-06-08 2011-12-15 Proyecto De Biomedicina Cima, S.L. New compositions and cell therapy methods for the treatment of cirrhosis
RU2477529C2 (en) * 2011-04-28 2013-03-10 Общество С Ограниченной Ответственностью "Научно-Производственная Фирма "Материа Медика Холдинг" Method for endothelial dysfunction correction by solution of homoeopathic dilutions of human endothelial nitrogen oxide synthase antibodies
KR20220061248A (en) 2013-07-12 2022-05-12 이베릭 바이오, 인크. Methods for treating or preventing ophthalmological conditions
WO2015089585A1 (en) * 2013-12-18 2015-06-25 Csl Limited Method of treating wounds
CN107537026A (en) * 2017-08-31 2018-01-05 中山大学中山眼科中心 VEGF B application
CN107661492A (en) * 2017-08-31 2018-02-06 中山大学中山眼科中心 VEGF B new application
US10745454B2 (en) * 2018-01-31 2020-08-18 Seyed Mohsen Asghari Method of synthesizing antagonist peptides for cell growth
CN109337931A (en) * 2018-11-02 2019-02-15 东北师范大学 The application of VEGFB gene and the construction method of VEGFB tumor inducing and tumor suppression animal model
CN110777146A (en) * 2019-11-28 2020-02-11 南通大学 Construction method of PDGFB (platelet-derived growth factor receptor) promoter activity report plasmid

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990013649A1 (en) * 1989-05-12 1990-11-15 Genentech, Inc. Production of vascular endothelial cell growth factor and dna encoding same
WO1991002058A1 (en) * 1989-07-27 1991-02-21 California Biotechnology Inc. Production of vascular endothelial cell growth factor

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659678A (en) * 1982-09-29 1987-04-21 Serono Diagnostics Limited Immunoassay of antigens
US4456550A (en) * 1982-11-22 1984-06-26 President And Fellows Of Harvard College Vascular permeability factor
US5036003A (en) * 1987-08-21 1991-07-30 Monsanto Company Antibodies to VPF
US5240848A (en) * 1988-11-21 1993-08-31 Monsanto Company Dna sequences encoding human vascular permeability factor having 189 amino acids
US5726152A (en) * 1990-09-21 1998-03-10 Merck & Co., Inc. Vascular endothelial cell growth factor II
DK0751992T3 (en) * 1994-03-08 2006-03-06 Human Genome Sciences Inc Karendothelial growth factor 2
US5928939A (en) * 1995-03-01 1999-07-27 Ludwig Institute For Cancer Research Vascular endothelial growth factor-b and dna coding therefor
US5607918A (en) * 1995-03-01 1997-03-04 Ludwig Institute For Cancer Research Vascular endothelial growth factor-B and DNA coding therefor
DE69630442T2 (en) * 1995-03-02 2004-08-19 Amrad Operations Pty. Ltd., Richmond A NEW GROWTH FACTOR AND A GENETIC SEQUENCE THAT CODES FOR THIS
EP0873348A4 (en) * 1995-06-06 2000-11-08 Human Genome Sciences Inc Human vascular endothelial growth factor 3

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990013649A1 (en) * 1989-05-12 1990-11-15 Genentech, Inc. Production of vascular endothelial cell growth factor and dna encoding same
WO1991002058A1 (en) * 1989-07-27 1991-02-21 California Biotechnology Inc. Production of vascular endothelial cell growth factor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CONN, GREG ET AL: "Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor", PROC. NATL. ACAD. SCI. U. S. A. (1990), 87(7), 2628-32, 1990, XP002114935 *
LEUNG, DAVID W. ET AL: "Vascular endothelial growth factor is a secreted angiogenic mitogen", SCIENCE (WASHINGTON, D. C., 1883-) (1989), 246(4935), 1306-9, 1989, XP000083690 *

Also Published As

Publication number Publication date
HK1008485A1 (en) 1999-07-30
AU741856B2 (en) 2001-12-13
DE69629181T2 (en) 2004-05-13
CN1176603A (en) 1998-03-18
AU5302196A (en) 1996-09-18
PT814827E (en) 2003-11-28
US6331301B1 (en) 2001-12-18
US5928939A (en) 1999-07-27
JP3297687B2 (en) 2002-07-02
WO1996026736A1 (en) 1996-09-06
DK0814827T3 (en) 2003-11-10
US5840693A (en) 1998-11-24
US7341996B2 (en) 2008-03-11
ATE245437T1 (en) 2003-08-15
JP3275024B2 (en) 2002-04-15
CA2211687A1 (en) 1996-09-06
ES2202432T3 (en) 2004-04-01
EP0814827A1 (en) 1998-01-07
JPH10510718A (en) 1998-10-20
JP2000228982A (en) 2000-08-22
EP0814827B1 (en) 2003-07-23
DE69629181D1 (en) 2003-08-28
US20050064493A1 (en) 2005-03-24
CA2211687C (en) 2011-05-24
CN1146440C (en) 2004-04-21
NO973933L (en) 1997-09-01
NZ305091A (en) 1998-11-25
US20030170253A1 (en) 2003-09-11
NO973933D0 (en) 1997-08-27

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