EP1092431A3 - Lasofoxifene compositions - Google Patents

Lasofoxifene compositions Download PDF

Info

Publication number
EP1092431A3
EP1092431A3 EP00308152A EP00308152A EP1092431A3 EP 1092431 A3 EP1092431 A3 EP 1092431A3 EP 00308152 A EP00308152 A EP 00308152A EP 00308152 A EP00308152 A EP 00308152A EP 1092431 A3 EP1092431 A3 EP 1092431A3
Authority
EP
European Patent Office
Prior art keywords
lasofoxifene
compositions
effect
potency
achieves
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP00308152A
Other languages
German (de)
French (fr)
Other versions
EP1092431A2 (en
EP1092431B1 (en
Inventor
David Duane Pfizer Central Research Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of EP1092431A2 publication Critical patent/EP1092431A2/en
Publication of EP1092431A3 publication Critical patent/EP1092431A3/en
Application granted granted Critical
Publication of EP1092431B1 publication Critical patent/EP1092431B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Based on lasofoxifene's half-life and potency, the drug may be dosed once per week and achieve a similar effect as if given daily. Accordingly the invention relates to novel lasofoxifene compositions and their manufacture which achieves this effect.
EP00308152A 1999-09-29 2000-09-19 Lasofoxifene compositions Expired - Lifetime EP1092431B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15665299P 1999-09-29 1999-09-29
US156652P 1999-09-29

Publications (3)

Publication Number Publication Date
EP1092431A2 EP1092431A2 (en) 2001-04-18
EP1092431A3 true EP1092431A3 (en) 2002-02-13
EP1092431B1 EP1092431B1 (en) 2006-09-13

Family

ID=22560457

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00308152A Expired - Lifetime EP1092431B1 (en) 1999-09-29 2000-09-19 Lasofoxifene compositions

Country Status (20)

Country Link
US (1) US6436977B1 (en)
EP (1) EP1092431B1 (en)
JP (1) JP2001097862A (en)
KR (1) KR100468246B1 (en)
AT (1) ATE339201T1 (en)
AU (1) AU781828B2 (en)
CA (1) CA2321369C (en)
CO (1) CO5200833A1 (en)
CY (1) CY1105235T1 (en)
DE (1) DE60030654T2 (en)
DK (1) DK1092431T3 (en)
ES (1) ES2269071T3 (en)
HU (1) HUP0003836A3 (en)
IL (1) IL138634A (en)
MY (1) MY121519A (en)
NZ (2) NZ507200A (en)
PE (1) PE20010680A1 (en)
PT (1) PT1092431E (en)
TW (1) TWI224001B (en)
ZA (1) ZA200005141B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968547A (en) 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
AU2756602A (en) * 2001-04-25 2002-10-31 Pfizer Products Inc. Methods and kits for treating depression or preventing deterioration of cognitive function
EP1406630A1 (en) 2001-07-06 2004-04-14 Endo Pharmaceuticals Inc. Parenteral administration of 6-hydroxy-oxymorphone for use as an analgesic
PA8576201A1 (en) * 2002-07-10 2004-05-26 Pfizer Prod Inc PHARMACEUTICAL COMPOSITION THAT HAS A DISTRIBUTION AND UNIFORM POWER OF FARMACO
JP2010509370A (en) * 2006-11-10 2010-03-25 シンダックス ファーマシューティカルズ，インク． Combination of ERα + ligand and histone deacetylase inhibitor for the treatment of cancer
US20100298270A1 (en) * 2007-07-23 2010-11-25 Syndax Pharmaceuticals, Inc. Novel Compounds and Methods of Using Them
WO2009015237A1 (en) * 2007-07-23 2009-01-29 Syndax Pharmaceuticals, Inc. Novel compounds and methods of using them
US20090149511A1 (en) * 2007-10-30 2009-06-11 Syndax Pharmaceuticals, Inc. Administration of an Inhibitor of HDAC and an mTOR Inhibitor
US20090131367A1 (en) * 2007-11-19 2009-05-21 The Regents Of The University Of Colorado Combinations of HDAC Inhibitors and Proteasome Inhibitors
WO2009126662A1 (en) * 2008-04-08 2009-10-15 Syndax Pharmaceuticals, Inc. Administration of an inhibitor of hdac, an inhibitor of her-2, and a selective estrogen receptor modulator
PL3525774T3 (en) 2016-10-11 2022-04-25 Duke University Lasofoxifene treatment of er+ breast cancer
CN117771239A (en) 2018-04-10 2024-03-29 杜克大学 Lasofoxifene treatment of breast cancer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996021656A1 (en) * 1995-01-09 1996-07-18 Pfizer, Inc. Estrogen agonists/antagonists
EP0792641A1 (en) * 1996-02-28 1997-09-03 Pfizer Inc. Use of estrogen antagonists and estrogen agonists in inhibiting pathological conditions
EP1004306A2 (en) * 1998-08-06 2000-05-31 Pfizer Products Inc. Estrogen agonists/antagonists
EP1086692A2 (en) * 1999-07-28 2001-03-28 Pfizer Products Inc. Estrogen agonists and antagonists for multiple indications

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5296486A (en) 1991-09-24 1994-03-22 Boehringer Ingelheim Pharmaceuticals, Inc. Leukotriene biosynthesis inhibitors
US5366965A (en) * 1993-01-29 1994-11-22 Boehringer Mannheim Gmbh Regimen for treatment or prophylaxis of osteoporosis
GB2324726A (en) * 1997-05-01 1998-11-04 Merck & Co Inc Combination Therapy for the Treatment of Osteoporosis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996021656A1 (en) * 1995-01-09 1996-07-18 Pfizer, Inc. Estrogen agonists/antagonists
EP0792641A1 (en) * 1996-02-28 1997-09-03 Pfizer Inc. Use of estrogen antagonists and estrogen agonists in inhibiting pathological conditions
EP1004306A2 (en) * 1998-08-06 2000-05-31 Pfizer Products Inc. Estrogen agonists/antagonists
EP1086692A2 (en) * 1999-07-28 2001-03-28 Pfizer Products Inc. Estrogen agonists and antagonists for multiple indications

Also Published As

Publication number Publication date
MY121519A (en) 2006-01-28
HU0003836D0 (en) 2000-12-28
CO5200833A1 (en) 2002-09-27
PE20010680A1 (en) 2001-06-29
ES2269071T3 (en) 2007-04-01
AU5661800A (en) 2001-04-05
CA2321369C (en) 2007-07-17
IL138634A0 (en) 2001-10-31
CA2321369A1 (en) 2001-03-29
IL138634A (en) 2006-08-01
KR20010061927A (en) 2001-07-07
ZA200005141B (en) 2002-03-26
EP1092431A2 (en) 2001-04-18
HUP0003836A2 (en) 2001-10-28
CY1105235T1 (en) 2010-03-03
EP1092431B1 (en) 2006-09-13
ATE339201T1 (en) 2006-10-15
NZ516413A (en) 2004-12-24
DE60030654D1 (en) 2006-10-26
US6436977B1 (en) 2002-08-20
PT1092431E (en) 2006-12-29
NZ507200A (en) 2004-12-24
DK1092431T3 (en) 2006-12-18
AU781828B2 (en) 2005-06-16
KR100468246B1 (en) 2005-01-27
HUP0003836A3 (en) 2002-09-30
JP2001097862A (en) 2001-04-10
TWI224001B (en) 2004-11-21
DE60030654T2 (en) 2007-04-05

Similar Documents

Publication Publication Date Title
ZA200206905B (en) Azetidine derivatives, preparation thereof and pharmaceutical compositions containing same.
HK1045650A1 (en) Pharmaceutical composition.
HUP0203190A3 (en) Glucopyranosyloxypyrazole derivatives, medicinal compositions containing the same and intermediates in the production thereof
HUP0102372A3 (en) Dihydropyrimidines, preparation thereof and pharmaceutical compositions containing the same
HUP0400636A3 (en) Pharmaceutical compositions containing azetidine derivatives, novel azetidine derivatives and preparation thereof
HK1042845A1 (en) Cosmetic composition.
AU3192700A (en) Medicinal compositions
HUP0202489A3 (en) Compositions containing solubilized, acid-enhanced antiperspirant active
HK1038884A1 (en) Medicinal compositions.
ZA200108248B (en) Antiperspirant compositions.
AU2005300A (en) Medicinal compositions
AU1887401A (en) Medicinal composition
EP1092431A3 (en) Lasofoxifene compositions
SI1268522T1 (en) Novel lhrh-antagonists, production and use thereof as medicament
AU3976800A (en) Antiperspirant compositions
WO2001078682A3 (en) Sustained release drug compositions
AU2002368133A1 (en) 1,3-azole derivative and medicinal composition containing the derivative for treatment for thombosis
AU1799800A (en) One-pack type post-foamable oxidation hair-dye compositions
AU2001260110A1 (en) Novel LHRH-antagonists, Production and Use Thereof as Medicament
AU4914400A (en) Novel pharmaceutical composition
AU7655600A (en) 1,4-dioxacycloalkane-2-one and 1,4-dioxacycloalkene-2-one
IL146812A0 (en) Streptogramin derivatives, production thereof and compositions containing the same
IL149749A0 (en) N-(1-phenylethyl)-5-phenylimidazole-2-amine compounds, their compositions and uses
AU1022201A (en) Novel LTB4 antagonist, method for the production thereof and its use as a medicament
AU2001277443A1 (en) Phenoxazine compounds, the compositions containing them and their medicinal uses

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20001002

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

RIC1 Information provided on ipc code assigned before grant

Free format text: 7A 61K 31/00 A, 7A 61K 31/40 B, 7A 61P 3/04 B, 7A 61P 3/06 B, 7A 61P 5/24 B, 7A 61P 9/00 B, 7A 61P 13/08 B, 7A 61P 19/10 B

17Q First examination report despatched

Effective date: 20020701

AKX Designation fees paid

Free format text: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAC Information related to communication of intention to grant a patent modified

Free format text: ORIGINAL CODE: EPIDOSCIGR1

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 35/00 20060101ALI20060201BHEP

Ipc: A61P 9/00 20060101ALI20060201BHEP

Ipc: A61K 31/40 20060101AFI20060201BHEP

Ipc: A61P 19/10 20060101ALI20060201BHEP

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: E. BLUM & CO. PATENTANWAELTE

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REF Corresponds to:

Ref document number: 60030654

Country of ref document: DE

Date of ref document: 20061026

Kind code of ref document: P

REG Reference to a national code

Ref country code: GR

Ref legal event code: EP

Ref document number: 20060403248

Country of ref document: GR

REG Reference to a national code

Ref country code: PT

Ref legal event code: SC4A

Free format text: AVAILABILITY OF NATIONAL TRANSLATION

Effective date: 20061031

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

ET Fr: translation filed
REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2269071

Country of ref document: ES

Kind code of ref document: T3

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20070614

REG Reference to a national code

Ref country code: CH

Ref legal event code: PFA

Owner name: PFIZER PRODUCTS INC.

Free format text: PFIZER PRODUCTS INC.#EASTERN POINT ROAD#GROTON, CONNECTICUT 06340 (US) -TRANSFER TO- PFIZER PRODUCTS INC.#EASTERN POINT ROAD#GROTON, CONNECTICUT 06340 (US)

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: PT

Payment date: 20080627

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20080708

Year of fee payment: 9

Ref country code: LU

Payment date: 20080731

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: AT

Payment date: 20080811

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20080925

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CY

Payment date: 20080910

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GR

Payment date: 20080704

Year of fee payment: 9

REG Reference to a national code

Ref country code: PT

Ref legal event code: MM4A

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20100319

BERE Be: lapsed

Owner name: *PFIZER PRODUCTS INC.

Effective date: 20090930

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20100319

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20090919

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20090919

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20090930

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20090930

Ref country code: GR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20100406

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20090930

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20100930

Year of fee payment: 11

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20090919

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IE

Payment date: 20110826

Year of fee payment: 12

Ref country code: DK

Payment date: 20110825

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20110901

Year of fee payment: 12

Ref country code: GB

Payment date: 20110826

Year of fee payment: 12

Ref country code: SE

Payment date: 20110909

Year of fee payment: 12

Ref country code: FI

Payment date: 20110906

Year of fee payment: 12

Ref country code: ES

Payment date: 20110905

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20110921

Year of fee payment: 12

Ref country code: NL

Payment date: 20110912

Year of fee payment: 12

REG Reference to a national code

Ref country code: NL

Ref legal event code: V1

Effective date: 20130401

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120919

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120920

REG Reference to a national code

Ref country code: SE

Ref legal event code: EUG

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20120919

REG Reference to a national code

Ref country code: DK

Ref legal event code: EBP

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20130531

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120919

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120919

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130403

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120919

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20121001

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130401

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 60030654

Country of ref document: DE

Effective date: 20130403

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20131018

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120920

Ref country code: DK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20121001