EP1142795A3 - Abdeckmatte - Google Patents

Abdeckmatte Download PDF

Info

Publication number
EP1142795A3
EP1142795A3 EP01106616A EP01106616A EP1142795A3 EP 1142795 A3 EP1142795 A3 EP 1142795A3 EP 01106616 A EP01106616 A EP 01106616A EP 01106616 A EP01106616 A EP 01106616A EP 1142795 A3 EP1142795 A3 EP 1142795A3
Authority
EP
European Patent Office
Prior art keywords
cover
balancing layer
cover sheet
microtiter plate
laminate consisting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP01106616A
Other languages
English (en)
French (fr)
Other versions
EP1142795B8 (de
EP1142795B1 (de
EP1142795A2 (de
Inventor
Wolfgang Dr. Heimberg
Markus Schürf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
MWG Biotech AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MWG Biotech AG filed Critical MWG Biotech AG
Publication of EP1142795A2 publication Critical patent/EP1142795A2/de
Publication of EP1142795A3 publication Critical patent/EP1142795A3/de
Application granted granted Critical
Publication of EP1142795B1 publication Critical patent/EP1142795B1/de
Publication of EP1142795B8 publication Critical patent/EP1142795B8/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples

Abstract

Die Erfindung betrifft eine Abdeckmatte. Sie ist zum Abdecken mehrerer in einem plattenförmigen Körper ausgebildeter, nach oben offener Reaktionsgefäße, vorgesehen, die zum Ausführen chemischer und/oder mikrobiologischer Reaktionen, wie z.B. dem PCR-Verfahren, verwendet werden. Die Abdeckmatte ist aus einem elastischen Material ausgebildet, wobei die Abdeckmatte eine weiche untere Lage aufweist, die zur Versteifung mit einer Trägerplatte versehen ist, und die Trägerplatte derart gekrümmt ist, daß sie bei einer auf die gesamte Fläche der Trägerplatte mit einem ebenflächigen Druckkörper aufgebrachten Druckbelastung von zumindest 5 N sich elastisch an den ebenflächigen Druckkörper anschmiegt und eine entsprechend krümmungsfreie Form einnimmt.
Die Abdeckmatte kann mit geringer Kraft von den Reaktionsgefäßen abgehoben werden, selbst wenn die in den Reaktionsgefäßen durchgeführten Reaktionen einen Unterdruck erzeugen.
EP01106616A 2000-04-08 2001-03-15 Abdeckmatte Expired - Lifetime EP1142795B8 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE20006546U DE20006546U1 (de) 2000-04-08 2000-04-08 Abdeckmatte
DE20006546U 2000-04-08

Publications (4)

Publication Number Publication Date
EP1142795A2 EP1142795A2 (de) 2001-10-10
EP1142795A3 true EP1142795A3 (de) 2003-11-19
EP1142795B1 EP1142795B1 (de) 2005-12-28
EP1142795B8 EP1142795B8 (de) 2006-03-22

Family

ID=7940031

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01106616A Expired - Lifetime EP1142795B8 (de) 2000-04-08 2001-03-15 Abdeckmatte

Country Status (7)

Country Link
US (1) US6518060B2 (de)
EP (1) EP1142795B8 (de)
JP (1) JP3843754B2 (de)
AT (1) ATE314277T1 (de)
DE (2) DE20006546U1 (de)
ES (1) ES2254276T3 (de)
NO (1) NO20011768L (de)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1012996C2 (nl) * 1999-09-08 2001-03-12 Micronic B V Afsluitmat voor het afsluiten van reageerbuizen.
ATE237399T1 (de) 1999-09-29 2003-05-15 Tecan Trading Ag Thermocycler sowie hebeelement für mikrotiterplatte
US7169355B1 (en) 2000-02-02 2007-01-30 Applera Corporation Apparatus and method for ejecting sample well trays
US6939516B2 (en) * 2000-09-29 2005-09-06 Becton, Dickinson And Company Multi-well plate cover and assembly adapted for mechanical manipulation
US6896848B1 (en) * 2000-12-19 2005-05-24 Tekcel, Inc. Microplate cover assembly
US6890488B2 (en) * 2001-06-22 2005-05-10 Matrix Technologies, Inc. Apparatus for sealing test tubes and the like
US7584240B2 (en) 2001-11-07 2009-09-01 Genvault Corporation Automated biological sample archive for storage, retrieval and analysis of large numbers of samples for remote clients
US20030087455A1 (en) * 2001-11-07 2003-05-08 Eggers Mitchell D Sample carrier system
US20030129755A1 (en) * 2001-11-07 2003-07-10 Genvault Corporation System and method of storing and retrieving storage elements
DE10205977A1 (de) * 2002-02-08 2003-08-28 Eppendorf Ag Workstation zum Durchführen von chemischen und biologischen Verfahren in Mikrotiterplatten
DE10302895B4 (de) * 2002-02-08 2005-04-14 Eppendorf Ag Abdeckung für die Öffnungen von in Mikrotiterplatten ausgebildeten Reaktionsgefäßen
US7198759B2 (en) * 2002-07-26 2007-04-03 Applera Corporation Microfluidic devices, methods, and systems
US7452712B2 (en) 2002-07-30 2008-11-18 Applied Biosystems Inc. Sample block apparatus and method of maintaining a microcard on a sample block
US6730883B2 (en) * 2002-10-02 2004-05-04 Stratagene Flexible heating cover assembly for thermal cycling of samples of biological material
US7718442B2 (en) * 2002-11-22 2010-05-18 Genvault Corporation Sealed sample storage element system and method
US7169602B2 (en) * 2002-12-04 2007-01-30 Applera Corporation Sample substrate for use in biological testing and method for filling a sample substrate
US7332348B2 (en) * 2003-02-28 2008-02-19 Applera Corporation Sample substrate having a divided sample chamber and method of loading thereof
US20100075858A1 (en) * 2003-04-29 2010-03-25 Genvault Corporation Biological bar code
US20050232818A1 (en) * 2003-09-19 2005-10-20 Donald Sandell Single sheet seal applicator and cartridge
US20070015289A1 (en) * 2003-09-19 2007-01-18 Kao H P Dispenser array spotting
US20060013984A1 (en) * 2003-09-19 2006-01-19 Donald Sandell Film preparation for seal applicator
US20050226779A1 (en) * 2003-09-19 2005-10-13 Oldham Mark F Vacuum assist for a microplate
US20050221358A1 (en) * 2003-09-19 2005-10-06 Carrillo Albert L Pressure chamber clamp mechanism
US20060029948A1 (en) * 2003-09-19 2006-02-09 Gary Lim Sealing cover and dye compatibility selection
US20050226780A1 (en) * 2003-09-19 2005-10-13 Donald Sandell Manual seal applicator
US20060011305A1 (en) * 2003-09-19 2006-01-19 Donald Sandell Automated seal applicator
US20050226771A1 (en) * 2003-09-19 2005-10-13 Lehto Dennis A High speed microplate transfer
WO2005029041A2 (en) * 2003-09-19 2005-03-31 Applera Corporation High density sequence detection methods and apparatus
US20050233472A1 (en) * 2003-09-19 2005-10-20 Kao H P Spotting high density plate using a banded format
DE502004011280D1 (de) 2004-01-23 2010-07-29 Qiagen Gmbh Kontaminationsbarriere
EP1758937B1 (de) * 2004-05-24 2009-09-02 Genvault Corporation Stabile lagerung von protein und stabile lagerung von nukleinsäure in wiedergewinnbarer form
US20050282270A1 (en) * 2004-06-21 2005-12-22 Applera Corporation System for thermally cycling biological samples with heated lid and pneumatic actuator
JP4682008B2 (ja) * 2005-10-04 2011-05-11 キヤノン株式会社 生化学処理装置、これに用いる容器および検査装置
EP2040983A4 (de) * 2006-06-26 2011-08-03 Life Technologies Corp Komprimierbare transparente dichtung für offene mikroplatten
US20080318280A1 (en) * 2007-02-13 2008-12-25 Eppendorf Ag Cover for an array of reaction vessels for one-step operation modus
EP2359933B1 (de) * 2007-02-13 2017-11-08 Eppendorf AG Probenabdeckung mit probengrößenunabhängiger Höhenregulierung
EP1961484B1 (de) * 2007-02-13 2016-07-20 Eppendorf Ag Deckel für Proben mit homogener Druckanwendung
US20080233015A1 (en) * 2007-03-23 2008-09-25 Bioinnovations Oy Device and method for use in analysis
US10302567B2 (en) 2007-12-19 2019-05-28 Berylliant, Inc. High throughput methods for analysis of contamination in environmental samples
US20110156090A1 (en) * 2008-03-25 2011-06-30 Lin Charles W C Semiconductor chip assembly with post/base/post heat spreader and asymmetric posts
US20100209957A1 (en) * 2008-06-20 2010-08-19 Genvault Corporation Biosample storage devices and methods of use thereof
US20100008828A1 (en) * 2008-07-11 2010-01-14 Bambi Lyn Cahilly Well plate seal structure
WO2010031007A2 (en) 2008-09-12 2010-03-18 Genvault Corporation Matrices and media for storage and stabilization of biomolecules
CA2724106C (en) * 2009-12-10 2018-04-17 F. Hoffmann-La Roche Ag Multiwell plate and lid
US10330343B2 (en) * 2012-02-22 2019-06-25 T2 Biosystems, Inc. Devices for control of condensation and methods of use thereof
DE102013200193A1 (de) 2013-01-09 2014-07-10 Hamilton Bonaduz Ag Probenverarbeitungssystem mit Dosiervorrichtung und Thermocycler
MX2015013421A (es) 2013-03-19 2016-07-05 Life Technologies Corp Cubierta para termociclador.
US9499896B2 (en) 2013-09-18 2016-11-22 Neumodx Molecular, Inc. Thermocycling system, composition, and microfabrication method
US9539576B2 (en) 2013-09-18 2017-01-10 Neumodx Molecular, Inc. Thermocycling system and manufacturing method
DE102013114732A1 (de) 2013-12-20 2015-06-25 Hamilton Bonaduz Ag Abdeckvorrichtung, insbesondere Deckel für die Abdeckung von Reaktionsgefäßen
GB2591198B (en) * 2014-04-04 2021-10-27 It Is Int Ltd Biochemical reaction system
GB201604062D0 (en) * 2016-03-09 2016-04-20 Cell Therapy Catapult Ltd A device for heating or cooling a sample
CN109789411A (zh) * 2016-10-07 2019-05-21 勃林格殷格翰维特梅迪卡有限公司 用于测试特别是生物样品的储物筒
DE102018124408A1 (de) * 2018-10-02 2020-04-02 Biometra GmbH Vorrichtung zur thermischen Behandlung von Proben
CN109806923A (zh) * 2019-01-29 2019-05-28 莫纳（苏州）生物科技有限公司 一种pcr基座及pcr仪

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5282543A (en) * 1990-11-29 1994-02-01 The Perkin Elmer Corporation Cover for array of reaction tubes
US5604130A (en) * 1995-05-31 1997-02-18 Chiron Corporation Releasable multiwell plate cover
WO1999061152A1 (en) * 1998-05-26 1999-12-02 Mj Research, Inc. Automation-compatible slide format sample cartridge

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2771399A (en) * 1954-10-12 1956-11-20 Upjohn Co Process and apparatus for determining biological potency of a substance in a liquid substrate
EP0388159A3 (de) * 1989-03-15 1991-06-12 Seiko Instruments Inc. Gerät zur Versieglung einer Flüssigkeit in Hohlräumen
US5721136A (en) * 1994-11-09 1998-02-24 Mj Research, Inc. Sealing device for thermal cycling vessels
US5851492A (en) * 1997-09-30 1998-12-22 Blattner; Frederick R. Microtiter plate sealing system
DE29720432U1 (de) * 1997-11-19 1999-03-25 Mwg Biotech Gmbh Roboter
DE19859586C1 (de) * 1998-12-22 2000-07-13 Mwg Biotech Ag Thermocyclervorrichtung

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5282543A (en) * 1990-11-29 1994-02-01 The Perkin Elmer Corporation Cover for array of reaction tubes
US5604130A (en) * 1995-05-31 1997-02-18 Chiron Corporation Releasable multiwell plate cover
WO1999061152A1 (en) * 1998-05-26 1999-12-02 Mj Research, Inc. Automation-compatible slide format sample cartridge

Also Published As

Publication number Publication date
DE20006546U1 (de) 2001-08-23
EP1142795B8 (de) 2006-03-22
EP1142795B1 (de) 2005-12-28
US6518060B2 (en) 2003-02-11
US20020028507A1 (en) 2002-03-07
ATE314277T1 (de) 2006-01-15
DE50108502D1 (de) 2006-02-02
NO20011768D0 (no) 2001-04-06
JP2001352967A (ja) 2001-12-25
NO20011768L (no) 2001-10-09
ES2254276T3 (es) 2006-06-16
EP1142795A2 (de) 2001-10-10
JP3843754B2 (ja) 2006-11-08

Similar Documents

Publication Publication Date Title
EP1142795B8 (de) Abdeckmatte
AU2002359508A1 (en) Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like
WO1999000655A3 (en) Rapid flow-through binding assay apparatus and method
AU2862995A (en) Method and apparatus for fabricating microarrays of biological samples
EP1391242A3 (de) Mikrosäulenbasierte Anordnung zur Hochdurchsatzanalyse
WO2001043871A3 (en) Microarray hybridization chamber
WO2003036265A3 (en) Assay systems with adjustable fluid communication
EP1959255A3 (de) Biochemische Analysatoren mit geschlossenem Regelkreis
WO2004011592A3 (en) Petal-array support for use with microplates
EP1541237A3 (de) Vorrichtung zur Durchführung von mehreren Polymerase-Kettenreaktionen
WO2005072873A3 (en) Diffusion-aided loading system for microfluidic devices
WO2004074818A3 (en) Assay apparatus and method using microfluidic arrays
WO2003065976A3 (en) Microfluidics apparatus and methods of use therefor
WO2002035260A3 (en) Light detection device
WO2003083040A3 (en) Graft polymer matrices
WO2002026384A3 (en) Multi-well assay plate and plate holder and method of assembling the same
WO2002085185A3 (en) Hydrophilic diagnostic devices
DE69911783D1 (de) Platte zur analyse und aufbewahrung von biologischen proben
EP0763130A4 (de) Biologischer test auf mikrobielle kontamination
WO2007067189A3 (en) System and methods for biological assays
EP1251352A3 (de) Reaktionsapparat und dessen Verwendung in einem Verfahren zur Analyse von biologisch aktiven Substanzen
AU2001286756A1 (en) Device for identifying the presence of a nucleotide sequence in a dna sample
CA2323716A1 (fr) Dispositif automatique de realisation d'echantillons en vue de la mise en oeuvre de reactions chimiques ou biologiques en milieu liquide
WO2001049415A3 (en) Pipet for liquid exchange
FR2839660B1 (fr) Microreacteur,son procede de preparation,et procede pour realiser une reaction biochimique ou biologique

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

RIC1 Information provided on ipc code assigned before grant

Ipc: 7G 01N 35/00 B

Ipc: 7B 01L 3/14 B

Ipc: 7B 01L 3/00 B

Ipc: 7B 01L 7/00 B

Ipc: 7C 12Q 1/68 B

Ipc: 7B 65D 51/02 A

17P Request for examination filed

Effective date: 20040119

AKX Designation fees paid

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20051228

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20051228

Ref country code: IE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20051228

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: LANGUAGE OF EP DOCUMENT: GERMAN

RAP2 Party data changed (patent owner data changed or rights of a patent transferred)

Owner name: F.HOFFMANN-LA ROCHE AG

REF Corresponds to:

Ref document number: 50108502

Country of ref document: DE

Date of ref document: 20060202

Kind code of ref document: P

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20060315

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20060328

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20060328

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20060328

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20060331

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20060331

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20060331

NLT2 Nl: modifications (of names), taken from the european patent patent bulletin

Owner name: F.HOFFMANN-LA ROCHE AG

Effective date: 20060201

GBT Gb: translation of ep patent filed (gb section 77(6)(a)/1977)

Effective date: 20060316

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: A. BRAUN, BRAUN, HERITIER, ESCHMANN AG PATENTANWAE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20060529

NLV1 Nl: lapsed or annulled due to failure to fulfill the requirements of art. 29p and 29m of the patents act
REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2254276

Country of ref document: ES

Kind code of ref document: T3

ET Fr: translation filed
REG Reference to a national code

Ref country code: IE

Ref legal event code: FD4D

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20060929

BERE Be: lapsed

Owner name: MWG -BIOTECH A.G.

Effective date: 20060331

REG Reference to a national code

Ref country code: CH

Ref legal event code: PFA

Owner name: F. HOFFMANN-LA ROCHE AG

Free format text: F. HOFFMANN-LA ROCHE AG#GRENZACHERSTRASSE 124#4070 BASEL (CH) -TRANSFER TO- F. HOFFMANN-LA ROCHE AG#GRENZACHERSTRASSE 124#4070 BASEL (CH)

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20051228

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20051228

REG Reference to a national code

Ref country code: DE

Ref legal event code: R082

Ref document number: 50108502

Country of ref document: DE

Representative=s name: PATRONUS IP PATENT- & RECHTSANWAELTE BERNHARD , DE

REG Reference to a national code

Ref country code: CH

Ref legal event code: PCAR

Free format text: NEW ADDRESS: HOLBEINSTRASSE 36-38, 4051 BASEL (CH)

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 16

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20160311

Year of fee payment: 16

Ref country code: CH

Payment date: 20160125

Year of fee payment: 16

Ref country code: ES

Payment date: 20160302

Year of fee payment: 16

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20160224

Year of fee payment: 16

Ref country code: FR

Payment date: 20160223

Year of fee payment: 16

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20160324

Year of fee payment: 16

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 50108502

Country of ref document: DE

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20170315

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20171130

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170331

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20171003

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170315

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170315

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170331

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170331

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20180705

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170316