EP1917957A3 - Biodegradable ocular implant - Google Patents

Biodegradable ocular implant Download PDF

Info

Publication number
EP1917957A3
EP1917957A3 EP08002892A EP08002892A EP1917957A3 EP 1917957 A3 EP1917957 A3 EP 1917957A3 EP 08002892 A EP08002892 A EP 08002892A EP 08002892 A EP08002892 A EP 08002892A EP 1917957 A3 EP1917957 A3 EP 1917957A3
Authority
EP
European Patent Office
Prior art keywords
ocular implant
biodegradable ocular
ocular region
implants
implantation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP08002892A
Other languages
German (de)
French (fr)
Other versions
EP1917957B1 (en
EP1917957A2 (en
Inventor
David Weber
David Chou
Lin Peng
Thierry Nivaggioli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Priority to EP19174341.8A priority Critical patent/EP3563839A1/en
Priority to EP16198417.4A priority patent/EP3187177B1/en
Priority to EP17188114.7A priority patent/EP3305284B1/en
Priority to EP14165593.6A priority patent/EP2799064B1/en
Priority to DK16198417.4T priority patent/DK3187177T3/en
Priority to DK14165593.6T priority patent/DK2799064T3/en
Publication of EP1917957A2 publication Critical patent/EP1917957A2/en
Publication of EP1917957A3 publication Critical patent/EP1917957A3/en
Application granted granted Critical
Publication of EP1917957B1 publication Critical patent/EP1917957B1/en
Priority to CY20181100250T priority patent/CY1120147T1/en
Priority to CY20191100615T priority patent/CY1121731T1/en
Priority to CY20191100865T priority patent/CY1121912T1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)

Abstract

The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
EP08002892.1A 2003-01-09 2004-01-07 Biodegradable ocular implant Expired - Lifetime EP1917957B1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP19174341.8A EP3563839A1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant
EP16198417.4A EP3187177B1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant
EP17188114.7A EP3305284B1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant
EP14165593.6A EP2799064B1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant
DK16198417.4T DK3187177T3 (en) 2003-01-09 2004-01-07 BIODEGRADABLE EYE IMPLANT
DK14165593.6T DK2799064T3 (en) 2003-01-09 2004-01-07 Bioerodible eye implant
CY20181100250T CY1120147T1 (en) 2003-01-09 2018-02-28 Biodegradable Ocular Implant
CY20191100615T CY1121731T1 (en) 2003-01-09 2019-06-13 BIODEGRADABLE EYE IMPLANT
CY20191100865T CY1121912T1 (en) 2003-01-09 2019-08-13 BIODEGRADABLE EYE IMPLANT

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/340,237 US20040137059A1 (en) 2003-01-09 2003-01-09 Biodegradable ocular implant
EP04700611A EP1581193B1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP04700611A Division EP1581193B1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant
EP04700611.9 Division 2004-01-07

Related Child Applications (5)

Application Number Title Priority Date Filing Date
EP19174341.8A Division EP3563839A1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant
EP16198417.4A Division EP3187177B1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant
EP14165593.6A Division-Into EP2799064B1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant
EP14165593.6A Division EP2799064B1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant
EP17188114.7A Division EP3305284B1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant

Publications (3)

Publication Number Publication Date
EP1917957A2 EP1917957A2 (en) 2008-05-07
EP1917957A3 true EP1917957A3 (en) 2011-06-15
EP1917957B1 EP1917957B1 (en) 2016-11-16

Family

ID=32711277

Family Applications (6)

Application Number Title Priority Date Filing Date
EP08002892.1A Expired - Lifetime EP1917957B1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant
EP19174341.8A Withdrawn EP3563839A1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant
EP14165593.6A Expired - Lifetime EP2799064B1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant
EP17188114.7A Expired - Lifetime EP3305284B1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant
EP04700611A Expired - Lifetime EP1581193B1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant
EP16198417.4A Expired - Lifetime EP3187177B1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant

Family Applications After (5)

Application Number Title Priority Date Filing Date
EP19174341.8A Withdrawn EP3563839A1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant
EP14165593.6A Expired - Lifetime EP2799064B1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant
EP17188114.7A Expired - Lifetime EP3305284B1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant
EP04700611A Expired - Lifetime EP1581193B1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant
EP16198417.4A Expired - Lifetime EP3187177B1 (en) 2003-01-09 2004-01-07 Biodegradable ocular implant

Country Status (21)

Country Link
US (1) US20040137059A1 (en)
EP (6) EP1917957B1 (en)
JP (1) JP4223040B2 (en)
KR (1) KR20050099008A (en)
CN (2) CN101259280A (en)
AT (1) ATE555779T1 (en)
AU (1) AU2004204744B2 (en)
BR (2) BRPI0406692A (en)
CA (1) CA2512315C (en)
CY (4) CY1118431T1 (en)
DK (5) DK2799064T3 (en)
ES (5) ES2613028T3 (en)
FR (1) FR12C0067I1 (en)
HK (1) HK1084021A1 (en)
HU (4) HUE030319T2 (en)
MX (1) MXPA05007342A (en)
NZ (1) NZ540451A (en)
PT (4) PT1917957T (en)
SI (3) SI3305284T1 (en)
TR (2) TR201908857T4 (en)
WO (1) WO2004062649A2 (en)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060280774A1 (en) * 1995-06-02 2006-12-14 Allergan, Inc. Compositions and methods for treating glaucoma
US5869079A (en) * 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US6726918B1 (en) 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
AU3649502A (en) 2000-11-29 2002-06-11 Oculex Pharm Inc Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US20050048099A1 (en) 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
EP1633320A2 (en) 2003-05-02 2006-03-15 SurModics, Inc. Implantable controlled release bioactive agent delivery device
US8246974B2 (en) 2003-05-02 2012-08-21 Surmodics, Inc. Medical devices and methods for producing the same
US7060723B2 (en) * 2003-08-29 2006-06-13 Allergan, Inc. Treating neurological disorders using selective antagonists of persistent sodium current
US7125908B2 (en) * 2003-08-29 2006-10-24 Allergan, Inc. Treating pain using selective antagonists of persistent sodium current
US20070224278A1 (en) 2003-11-12 2007-09-27 Lyons Robert T Low immunogenicity corticosteroid compositions
US20050101582A1 (en) 2003-11-12 2005-05-12 Allergan, Inc. Compositions and methods for treating a posterior segment of an eye
AU2005209201B2 (en) 2004-01-20 2010-06-03 Allergan, Inc. Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US20050244458A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular neuropathies
US8673341B2 (en) 2004-04-30 2014-03-18 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
US8425929B2 (en) * 2004-04-30 2013-04-23 Allergan, Inc. Sustained release intraocular implants and methods for preventing retinal dysfunction
US8685435B2 (en) 2004-04-30 2014-04-01 Allergan, Inc. Extended release biodegradable ocular implants
US8147865B2 (en) 2004-04-30 2012-04-03 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US20050244469A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
US9498457B2 (en) 2004-04-30 2016-11-22 Allergan, Inc. Hypotensive prostamide-containing biodegradable intraocular implants and related implants
US20050244472A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Intraocular drug delivery systems containing excipients with reduced toxicity and related methods
US20050244461A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Controlled release drug delivery systems and methods for treatment of an eye
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US20050244466A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Photodynamic therapy in conjunction with intraocular implants
US7993634B2 (en) 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US8119154B2 (en) 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
US20060275230A1 (en) 2004-12-10 2006-12-07 Frank Kochinke Compositions and methods for treating conditions of the nail unit
AU2005314426A1 (en) * 2004-12-10 2006-06-15 Talima Therapeutics, Inc. Compositions and methods for treating conditions of the nail unit
AU2011236024B2 (en) * 2005-03-01 2013-05-23 Allergan, Inc. Microimplants for ocular administration
US20060204548A1 (en) * 2005-03-01 2006-09-14 Allergan, Inc. Microimplants for ocular administration
US20090082321A1 (en) * 2007-09-21 2009-03-26 Allergan, Inc. Steroid containing drug delivery systems
US20070178138A1 (en) * 2006-02-01 2007-08-02 Allergan, Inc. Biodegradable non-opthalmic implants and related methods
US20070260203A1 (en) * 2006-05-04 2007-11-08 Allergan, Inc. Vasoactive agent intraocular implant
US8802128B2 (en) 2006-06-23 2014-08-12 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
EP1917971A1 (en) * 2006-10-27 2008-05-07 Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) Substained release formulations comprising very low molecular weight polymers
US8969415B2 (en) * 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems
US8536190B2 (en) * 2007-01-30 2013-09-17 Allergan, Inc. Treating unwanted ocular conditions using an ascomycin macrolactam
WO2008113043A1 (en) * 2007-03-14 2008-09-18 University Of Washington Device and method for intraocular drug delivery
US20080317805A1 (en) * 2007-06-19 2008-12-25 Mckay William F Locally administrated low doses of corticosteroids
MX2010002616A (en) * 2007-09-07 2010-08-04 Qlt Plug Delivery Inc Drug cores for sustained release of therapeutic agents.
US8353862B2 (en) 2007-11-02 2013-01-15 Allergan, Inc. Drug delivery systems and methods
US8524267B2 (en) * 2008-04-18 2013-09-03 Warsaw Orthopedic, Inc. Dexamethasone formulations in a biodegradable material
US9125917B2 (en) * 2008-04-18 2015-09-08 Warsaw Orthopedic, Inc. Fluocinolone formulations in a biodegradable polymer carrier
US9877973B2 (en) 2008-05-12 2018-01-30 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
EP2276439A4 (en) 2008-05-12 2013-11-27 Univ Utah Res Found Intraocular drug delivery device and associated methods
US10064819B2 (en) 2008-05-12 2018-09-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US10588855B2 (en) 2008-05-12 2020-03-17 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US9095404B2 (en) 2008-05-12 2015-08-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
EP2296621A1 (en) * 2008-05-20 2011-03-23 Yale University Biodegradable sustained-release polymeric microparticulates comprising a hydrophobic drug and determined for ophthalmic use
US20110206773A1 (en) * 2008-05-20 2011-08-25 Yale University Sustained delivery of drugs from biodegradable polymeric microparticles
CN101612111B (en) * 2008-06-24 2011-11-23 上海医药工业研究院 Sustained-release microsphere of nomegestrol acetate of analogs thereof and preparation method and application thereof
US10842669B2 (en) 2008-11-13 2020-11-24 Gholam A. Peyman Ophthalmic drug delivery method
US10272035B2 (en) 2008-11-13 2019-04-30 Gholam A. Peyman Ophthalmic drug delivery method
US20110125090A1 (en) * 2008-11-13 2011-05-26 Peyman Gholam A Ophthalmic drug delivery system and method
US20100204325A1 (en) * 2009-02-11 2010-08-12 Allergan, Inc. Valproic acid drug delivery systems and intraocular therapeutic uses thereof
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US20100303794A1 (en) 2009-05-29 2010-12-02 Allergan, Inc. Methods of Treating Urogenital-Neurological Disorders Using Glucagon Like Hormone Retargeted Endopepidases
US20100303788A1 (en) * 2009-05-29 2010-12-02 Allergan, Inc. Methods of Treating Chronic Neurogenic Inflammation Using Galanin Retargeted Endopepidases
US20100303783A1 (en) * 2009-05-29 2010-12-02 Allergan, Inc. Methods of Treating Urogenital-Neurological Disorders Using Tachykinin Retargeted Endopepidases
US20100303757A1 (en) 2009-05-29 2010-12-02 Allergan, Inc. Methods of Treating Chronic Neurogenic Inflammation Using Interleukin Retargeted Endopepidases
AU2010282273A1 (en) 2009-08-14 2012-03-15 Allergan, Inc. Methods of treating cancer using tachykinin retargeted endopeptidases
EP2464659A1 (en) 2009-08-14 2012-06-20 Allergan, Inc. Methods of treating cancer using opioid retargeted endpeptidases
IN2012DN02046A (en) 2009-08-14 2015-08-21 Allergan Inc
WO2011020117A2 (en) 2009-08-14 2011-02-17 Allergan, Inc. Methods of treating cancer using neurotrophin retargeted endopeptidases
CA2771298A1 (en) 2009-08-14 2011-02-17 Allergan, Inc. Methods of treating cancer using glucagon-like hormone retargeted endopeptidases
CN102573876A (en) * 2009-08-14 2012-07-11 阿勒根公司 Methods of treating cancer using galanin retargeted endpeptidases
KR20130020881A (en) 2010-02-08 2013-03-04 알러간, 인코포레이티드 Pyridazine derivatives useful as cannabinoid-2 agonists
WO2011119748A1 (en) 2010-03-24 2011-09-29 Allergan, Inc. Compositions comprising a prosamide for treating hair loss, hair thinning, hair color loss
US8349005B2 (en) 2011-01-03 2013-01-08 Masatoshi Murata Method for burying implant to choroid
WO2012112426A1 (en) 2011-02-14 2012-08-23 Allergan, Inc. Arginine vasopressin retargeted clostridial endopeptidases for use in treating benign prostatic hyperplasia
US20120207743A1 (en) 2011-02-14 2012-08-16 Allergan, Inc. Inhibiting Aberrant Blood Vessel Formation Using Retargeted Endopeptidases
WO2012112432A1 (en) 2011-02-14 2012-08-23 Allergan, Inc. Methods of inhibiting aberrant blood vessel formation using opioid retargeted endopeptidases
US20120207742A1 (en) 2011-02-14 2012-08-16 Allergan, Inc. Treatments Using PSMA Ligand Endopeptidases
WO2012112422A1 (en) 2011-02-14 2012-08-23 Allergan, Inc. Inhibiting aberrant blood vessel formation using growth factor retargeted endopeptidases
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
US9827401B2 (en) 2012-06-01 2017-11-28 Surmodics, Inc. Apparatus and methods for coating medical devices
MX351261B (en) 2012-06-01 2017-10-06 Surmodics Inc Apparatus and method for coating balloon catheters.
WO2014066644A1 (en) 2012-10-26 2014-05-01 Allergan, Inc. Ketorolac-containing sustained release drug delivery systems
WO2014113384A2 (en) * 2013-01-15 2014-07-24 The Regents Of The University Of Colorado, A Body Corporate Lacrimal system drug delivery device
JP2016514024A (en) 2013-03-14 2016-05-19 ハラックス，インコーポレイテッド How to treat nail infections, diseases or disorders
TR201802759T4 (en) * 2013-10-31 2018-03-21 Allergan Inc Prostamide-containing intraocular implants and methods of use.
RU2728195C2 (en) * 2014-02-26 2020-07-28 Аллерган, Инк. Device for delivery of intraocular implant and methods of its use
US20150342875A1 (en) 2014-05-29 2015-12-03 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US10363163B2 (en) 2014-09-11 2019-07-30 EyePoint Pharmaceuticals, Inc. Injector apparatus
FR3028410A1 (en) 2014-11-18 2016-05-20 Pierre Coulon MULTIFUNCTIONAL CAPSULAR IMPLANT
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
US11564833B2 (en) 2015-09-25 2023-01-31 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
USD851755S1 (en) 2015-10-22 2019-06-18 Eyepoint Pharmaceuticals Us, Inc. Ocular inserter
WO2017091404A1 (en) 2015-11-23 2017-06-01 The Regents Of The University Of Colorado, A Body Corporate Lacrimal system for drug delivery
US11318043B2 (en) 2016-04-20 2022-05-03 Dose Medical Corporation Bioresorbable ocular drug delivery device
JP7054211B2 (en) 2016-05-20 2022-04-13 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイト Lacrimal gland drug feeding device
WO2020112816A1 (en) 2018-11-29 2020-06-04 Surmodics, Inc. Apparatus and methods for coating medical devices
US11819590B2 (en) 2019-05-13 2023-11-21 Surmodics, Inc. Apparatus and methods for coating medical devices

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996038174A1 (en) * 1995-06-02 1996-12-05 Oculex Pharmaceuticals, Inc. Improved formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
WO2002043785A2 (en) * 2000-11-29 2002-06-06 Oculex Pharmaceuticals, Inc. Intraocular implants for preventing transplant rejection in the eye

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322323A (en) * 1980-12-01 1982-03-30 Alza Corporation Erodible device comprising surfactant for modifying the rate of erosion of the device
DE3168032D1 (en) * 1980-11-10 1985-02-14 Alza Corp Erodible polymer containing erosion rate modifier
US4883457A (en) * 1983-08-18 1989-11-28 Drug Delivery Systems Inc. Disposable and/or replenishable transdermal drug applicators and methods of manufacturing same
US6309669B1 (en) * 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
US6217911B1 (en) * 1995-05-22 2001-04-17 The United States Of America As Represented By The Secretary Of The Army sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres
US4863457A (en) 1986-11-24 1989-09-05 Lee David A Drug delivery device
JPS63291419A (en) * 1987-05-24 1988-11-29 Tatsumo Kk Heat treatment device
US4853224A (en) * 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4997652A (en) * 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
KR0185215B1 (en) * 1990-11-30 1999-05-01 요시다 쇼오지 A controlled-release pharmaceutical preparation for intra-ocular implant
US5378475A (en) * 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US5707643A (en) * 1993-02-26 1998-01-13 Santen Pharmaceutical Co., Ltd. Biodegradable scleral plug
ATE195065T1 (en) 1993-02-26 2000-08-15 Santen Pharmaceutical Co Ltd BIODEGRADABLE SCLERA PLUG
US5443505A (en) * 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US6369116B1 (en) 1995-06-02 2002-04-09 Oculex Pharmaceuticals, Inc. Composition and method for treating glaucoma
BR9607752B1 (en) * 1996-01-24 2009-05-05 controlled release microcapsule pharmaceutical formulation.
WO1999001156A1 (en) * 1997-07-02 1999-01-14 Santen Pharmaceutical Co., Ltd. Polylactic acid scleral plugs
US6306426B1 (en) * 1997-08-11 2001-10-23 Allergan Sales, Inc. Implant device with a retinoid for improved biocompatibility
US6217895B1 (en) * 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6726918B1 (en) * 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996038174A1 (en) * 1995-06-02 1996-12-05 Oculex Pharmaceuticals, Inc. Improved formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
WO2002043785A2 (en) * 2000-11-29 2002-06-06 Oculex Pharmaceuticals, Inc. Intraocular implants for preventing transplant rejection in the eye

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