EP2431475A3 - Bioabsorbable polymer containing 2-hydroxyacid monomers - Google Patents

Bioabsorbable polymer containing 2-hydroxyacid monomers Download PDF

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Publication number
EP2431475A3
EP2431475A3 EP20110193920 EP11193920A EP2431475A3 EP 2431475 A3 EP2431475 A3 EP 2431475A3 EP 20110193920 EP20110193920 EP 20110193920 EP 11193920 A EP11193920 A EP 11193920A EP 2431475 A3 EP2431475 A3 EP 2431475A3
Authority
EP
European Patent Office
Prior art keywords
pha
polyhydroxyalkanoate
glycolic acid
polymer
hydroxyacid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP20110193920
Other languages
German (de)
French (fr)
Other versions
EP2431475B1 (en
EP2431475A2 (en
Inventor
David P Martin
Frank A Skraly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tepha Inc
Original Assignee
Metabolix Inc
Tepha Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolix Inc, Tepha Inc filed Critical Metabolix Inc
Publication of EP2431475A2 publication Critical patent/EP2431475A2/en
Publication of EP2431475A3 publication Critical patent/EP2431475A3/en
Application granted granted Critical
Publication of EP2431475B1 publication Critical patent/EP2431475B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31507—Of polycarbonate

Abstract

The present invention relates to a method of producing 2-hydroxyacid-containing polymer comprising expressing in an organism genes encoding a polyhydroxyalkanoate (PHA) synthase and at least one enzyme for the production of 2-hydroxyacyl Co-A. Preferably the method is a method of producing glycolic acid-containing polyhydroxyalkanoate polymer comprising feeding glycolic acid or a substrate converted to 2-hydroxyacid units to bacteria or plants expressing a polyhydroxyalkanoate (PHA) synthase and at least one enzyme for the production of 2-hydroxyacyl Co-A to produce the glycolic acid-containing polymer. The present invention also relates to the use of a laser to prepare a porous PHA polymer, by melt or solvent processing the PHA into a mold and perforating the material with the laser to achieve the desired porosity.
EP11193920.3A 2002-05-10 2003-05-07 Bioabsorbable polymer containing 2-hydroxyacid monomers Expired - Lifetime EP2431475B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37958302P 2002-05-10 2002-05-10
EP20030808364 EP1654373B1 (en) 2002-05-10 2003-05-07 Bioabsorbable polymer containing 2-hydroxyacid monomers
PCT/US2003/014573 WO2004038030A2 (en) 2002-05-10 2003-05-07 Bioabsorbable polymer containing 2-hdroxyacid monomers

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
EP03808364.8 Division 2003-05-07
EP20030808364 Division-Into EP1654373B1 (en) 2002-05-10 2003-05-07 Bioabsorbable polymer containing 2-hydroxyacid monomers
EP20030808364 Division EP1654373B1 (en) 2002-05-10 2003-05-07 Bioabsorbable polymer containing 2-hydroxyacid monomers

Publications (3)

Publication Number Publication Date
EP2431475A2 EP2431475A2 (en) 2012-03-21
EP2431475A3 true EP2431475A3 (en) 2012-06-20
EP2431475B1 EP2431475B1 (en) 2019-07-10

Family

ID=32176356

Family Applications (2)

Application Number Title Priority Date Filing Date
EP11193920.3A Expired - Lifetime EP2431475B1 (en) 2002-05-10 2003-05-07 Bioabsorbable polymer containing 2-hydroxyacid monomers
EP20030808364 Expired - Lifetime EP1654373B1 (en) 2002-05-10 2003-05-07 Bioabsorbable polymer containing 2-hydroxyacid monomers

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP20030808364 Expired - Lifetime EP1654373B1 (en) 2002-05-10 2003-05-07 Bioabsorbable polymer containing 2-hydroxyacid monomers

Country Status (6)

Country Link
US (2) US8039237B2 (en)
EP (2) EP2431475B1 (en)
JP (2) JP4780961B2 (en)
AU (1) AU2003301617A1 (en)
ES (2) ES2741964T3 (en)
WO (1) WO2004038030A2 (en)

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WO2015143000A1 (en) 2014-03-18 2015-09-24 Tepha, Inc. Micro-fiber webs of poly-4-hydroxybutyrate and copolymers thereof produced by centrifugal spinning
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Also Published As

Publication number Publication date
EP1654373B1 (en) 2012-08-15
US20120021471A1 (en) 2012-01-26
JP2009261398A (en) 2009-11-12
US20030211131A1 (en) 2003-11-13
ES2395142T3 (en) 2013-02-08
WO2004038030A2 (en) 2004-05-06
EP2431475B1 (en) 2019-07-10
US8039237B2 (en) 2011-10-18
ES2741964T3 (en) 2020-02-12
JP4975782B2 (en) 2012-07-11
AU2003301617A1 (en) 2004-05-13
WO2004038030A3 (en) 2006-10-05
EP1654373A4 (en) 2009-10-21
JP2006501858A (en) 2006-01-19
EP1654373A2 (en) 2006-05-10
US8703449B2 (en) 2014-04-22
AU2003301617A8 (en) 2004-05-13
JP4780961B2 (en) 2011-09-28
EP2431475A2 (en) 2012-03-21

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