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Publication numberUS108034 A
Publication typeGrant
Publication dateOct 4, 1870
Publication numberUS 108034 A, US 108034A, US-A-108034, US108034 A, US108034A
InventorsFrederic Kratis
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Improvement in putting up medicines
US 108034 A
Abstract  available in
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Claims  available in
Description  (OCR text may contain errors)

in the several figures.



Specification forming part of LettersPatent No. 108,034, dated October 4, 1870.

To all whom iii may concern.-

Be it known that I, FREDERIG KRAUS, of

Cincinnati, in the county of Hamilton and companying drawing, which makes part of this specification, and in which Figures 1 and2represent the slates on which my improved medicines are" prepared, and Figs. 3 and 4 represent specimens of my improved-medicine.

Like letters of reference indicate like parts The nature of my invention consists in putting up medicines in gelatinous tablets divided by indented lines into parts of equal size, each partbeing made to contain the desired dose of medicine, so that each tablet contains any desired number of equal doses; also,

. in the slates on which these medicines are prepared;

My invention has for its object the putting up of medicines in such a way that they can be taken with the greatest ease by the most delicate patients, while the doses are made equal with the most absolute certainty. Their bulk is so reduced that any quantity of various medicines may be carried by physicians withoutinconvenience, who thus may at once dispense the medicines they prescribe.

Druggists who preparemedicines in this manner in various doses are saved a great deal of trouble in compounding prescriptions, and the medicines can be safely kept without danger of spoiling.

I compound my improved medicines in tablets containing a large number of doses, and out these up into smaller tablets containing the number of doses prescribed.

Any kind of medicine which can be dissolved can be put up in this way; and I will now proceed to describe the preparation of sulphuric morphine as an'example.

I dissolve eighty grains of the finest, purest, and whitest gelatine in eight ounces distilled water at a proper degree of heat, preferably 63 Celsius. of morphine, thoroughly mixed in thirty-six drops of chemically-pure glycerine. Stir'the whole carefully, and then pour it evenly over the slate. I

This slate may be of any desired size; but I prefer making it siX inches by twelve and one-half, sothat when the same is perfectly polished and divided into squares of one-half inch, by means of double parallel lines engraved into the slate to the depth of about half a line, the slate will contain three hundred squares of perfectly equal size. In Fig. l I have shown this slatein its frameA, which may be constructed of wood, metal, or any other suitable material, and extends above the surface of the slate.

- The slate is made detachable from the frame,

so that different slates, being divided into larger or smaller squares, maybe used, accorddust, and allow the solution to dry at a temperature of about 40 to 45 Celsius. The

gelatinous tablet thus prepared easily loosens from the slate, and is then out between the parallel lines which have been formed on the same by the indented lines on the slate into smaller tablets of twelve or any other. desired number of squares, each square containing exactly one-fourth of a grain of sulphuric morphine, as shown in Fig. 3.

In Fig. 4 I have shown a tablet which is intended for medicines which are applied to the eyes, or other very tender parts of the body, in very small dosesas, for instance,

sulphuric atropine, which isapplied to the that the whole dose can be applied directly to the diseased portion of the eye, on' which it remains by reason of its gelatmouscharacter,

To this I add seventy-five grains and it cannot, on account of its fineness, irritate the most delicate part.

In traveling these medicine-tablets can be easily carried, and any person knowing the dose required can purchase these medicines and take them with perfect safety.

Having thus described my invention, what I claim as new, and desire to secure by Letters Patent, is

1. The method of preparing medicines in the manner substantially herein described.

2. Medicines or drugs put up in gelatinous tablets, which are divided into equal doses,in the manner substantially as herein described.

3. lhe slates shown in Figs. 1 and 2, for preparing gelatinous medicine tablets, substantially as herein described.




Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3863633 *May 24, 1972Feb 4, 1975Pharmacia AbComposition containing a substance showing a topical effect on the eye, and a method of preparing the same
US4179497 *Nov 13, 1978Dec 18, 1979Merck & Co., Inc.Solid state ophthalmic medication
US4265875 *Oct 19, 1979May 5, 1981Inveresk Research InternationalControlled release suppositories
US4292300 *Jul 20, 1977Sep 29, 1981Inveresk Research InternationalControlled release suppositories
Cooperative ClassificationA61K9/2054