US20010011173A1 - Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation - Google Patents

Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation Download PDF

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US20010011173A1
US20010011173A1 US09/827,861 US82786101A US2001011173A1 US 20010011173 A1 US20010011173 A1 US 20010011173A1 US 82786101 A US82786101 A US 82786101A US 2001011173 A1 US2001011173 A1 US 2001011173A1
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disk
shaft
plug
pin
accordance
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US09/827,861
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US6328743B2 (en
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Karl-Dieter Lerch
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Priority to US09/827,861 priority Critical patent/US6328743B2/en
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Priority to US10/011,379 priority patent/US6726688B2/en
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Publication of US6328743B2 publication Critical patent/US6328743B2/en
Priority to US10/793,814 priority patent/US6962591B2/en
Priority to US11/203,271 priority patent/US20060009772A1/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/688Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin for reattaching pieces of the skull
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/683Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin comprising bone transfixation elements, e.g. bolt with a distal cooperating element such as a nut

Definitions

  • the present background of the invention concerns a device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation.
  • the object of the present invention is a simpler and more rapid device for accurate and permanent postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation.
  • a device of the aforesaid genus comprising a pin and two concavoconvex disks of a physiologically compatible metal or metal compound.
  • the pin has a flat head at one end and one of the disks comes to rest against the head.
  • Each disk has row of teeth extending along the edge of the concave side and a bore through the center.
  • the shaft of the pin fits into the bore.
  • the disks can be mounted on the shaft with the teeth on each one facing the teeth on the other.
  • the second disk can be fastened to the shaft.
  • the inner disks in the aforesaid fixation device in accordance with the present invention are secured to the pins in the vicinity of the head.
  • the disks are then inserted through a slightly larger recess in the circumference of the plug, below the parts of the joint, with the shaft of the pin projecting out of the kerf between the plug and the rest of the cranium.
  • the outer disk is then mounted over the section of pin projecting out of the kerf.
  • the two disks are then approached until their teeth bite into the edges of both the plug and of the rest of the cranium.
  • the second disk is then secured to the shaft.
  • Titanium is particularly appropriate for the physiologically compatible metal. Such titanium alloys as Ti 6 A 6 Va are also appropriate.
  • a device made of titanium is of advantage because it will not distort postoperative computerized- tomography images.
  • the inner disk can be mounted more stable on the shaft of the pin if the transition between the head of the pin and the shaft is conical and dimensioned to ensure that a disk resting against the head will be forced tight around the shaft.
  • Slits can also extend radially outward from the bore through the first disk to be mounted on the shaft. The center of the disk can be depressed. Areas can be removed from the disks at regular intervals between the bore and the edge to conserve material.
  • the device can be applied to the two halves of bone by a procedure similar in principle to blind riveting.
  • Notches can accordingly be introduced into each shaft to prevent the second disk mounted thereon from sliding away from the head of the pin. If the second disk on the shaft is deformed in a direction opposite that of its concavoconvexity, the deformation alone will secure it to the shaft by compression.
  • the shaft can also be threaded and accommodate a nut. The nut can be tightened against the second disk. The second disk will in every case be displaced until its teeth engage the two halves of the joint, creating the desired fixation of the plug back into the rest of the cranium at the adjacent edges.
  • the novel device can be easily and rapidly manipulated and accomplishes the desired accurate and permanent postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation.
  • FIG. 1 is an exploded view of the device in accordance with the present invention
  • FIG. 2 is a view in the direction indicated by arrow II in FIG. 1 of one embodiment of the first disk mounted over the shaft of the pin,
  • FIG. 3 is a view in the direction indicated by arrow III in FIG. 1 of one embodiment of the second disk mounted over the shaft of the pin,
  • FIG. 4 is a longitudinal section of the components of the device assembled
  • FIG. 5 illustrates how the device in accordance with the present invention can be employed
  • FIG. 6 is a section along the line VI-VI in FIG. 5,
  • FIG. 7 is a schematic view and shows another embodiment of the present invention.
  • FIG. 8 is a schematic view of a still further embodiment according to the present invention.
  • a device for postoperatively fixing back into the cranium a plug of bone removed therefrom during a surgical operation comprises a pin 11 and two concavoconvex disks 21 and 22 .
  • the pin comprises a shaft 112 and a head 111 ,
  • Disk 21 the inner disk, is mounted on the shaft first and comes to rest against the inner surface of the plug and of the rest of the cranium that are to be united.
  • Disk 22 the outer disk, is mounted on the shaft next and comes to rest against the outer surface of the plug and the rest of the cranium.
  • the shaft 112 of pin 11 extends through the holes 211 and 221 of the disks in the assembled device.
  • a raw of teeth 213 extends along the edge 212 of the concave side of disk 21
  • a row of teeth 223 extends along the edge 222 of the concave side of disk 22 .
  • disks 21 and 22 are mounted on the shaft 112 of pin 11 with their teeth facing each other.
  • Shaft 112 fits tightly in the hole 211 through disk 21 .
  • Any disk can be provided as illustrated in FIG. 2 with slits 214 extending radially outward from the hole 211 through its center. If the transition between the head 111 and the shaft 112 of pin 11 is conical, slits 214 will as is desirable accurately position the disk in relation to the pin, both of which will accordingly support both the plug and the rest of the cranium once the device has been emplaced, The area between the hole through the center of any disk and its circumference can also be provided as illustrated in FIG. 3 with perforations 226 to conserve material and decrease weight. Each disk can have both slits 214 and perforations 226 .
  • FIG. 5 illustrates part of an adult cranium 31 from which a plug 32 of bone has been sawn to provide access to the brain, which is available to the surgeon through aperture 33 .
  • a recess 321 slightly larger than the disks has been removed from plug 32 at its circumference. once the operation is over, the plug is returned to the aperture 33 .
  • Inner disks 22 are mounted on the shafts 112 of pins 1 . The inner disks are inserted one by one through recess 321 with the shafts projecting out and slid along the inner surface of the plug and residual cranium with the shafts extending out of kerf 331 in the directions indicated by arrows A in FIG.
  • outer disks 22 are now mounted on the shafts of the pins in situ.
  • the outer disks are finally secured to the shafts with a tool of the type employed to fasten blind rivets.
  • the tool forces outer disks 22 and inner disks 21 together in the direction indicated by arrow B in FIG. 6 until the teeth on each disk bite into the tissue of the plug and of the residual cranium, securing the two together.
  • the section of each shaft extending out beyond the outer disk is now trimmed off.
  • the shaft can alternatively be threaded, and the disks forced together over the threads until the teeth bite into the tissue.
  • the shaft 112 of the pin 11 has notches 112 c engaging the outer surface of the second disk 22 and forcing it towards the head 111 of the pin.
  • the shaft of the pin 11 has a thread 112 a and accommodates a nut 112 b that can be screwed against the second disk 22 .

Abstract

A device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation. The device comprises a pin (11) and two concavoconvex disks (21 & 22) of a physiologically compatible metal or metal compound. The pin has a flat head (111) at one end and one (21) of the disks comes to rest against the head. Each disk has row of teeth (213 & 223), extending along the edge of the concave side and a bore (211 & 221) through the center. The shaft (112) of the pin fits into the bores. The disks can be mounted on the shaft with the teeth on each one facing the teeth on the other. The second disk can be fastened to the shaft.

Description

  • The present application is a continuation of U.S. patent Ser. No. 088,175, filed Jun. 1, 1998, which is a continuation of U.S. patent application Ser. No. 790,071, filed Jan. 28, 1997, now U.S. Pat. No. 5,800,436. [0001]
  • BACKGROUND OF THE INVENTION
  • The present background of the invention concerns a device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation. [0002]
  • It is often necessary during brain surgery to remove a plug of bone from the cranium to provide the surgeon with access to the field of operation. The plug is sawed out and must be replaced in the cranium after the operation and fixed thereto. Such plugs have long been fixed back into the rest of the cranium by suturing with loops of steel wire that extend through both and then twisting together the projecting ends of the emplaced loops. The contact between the plug and the rest of the cranium is relatively unstable, however. The two halves do not fuse together very well. The scalp can also become inflamed. Another drawback to such an approach is that the wire considerably distorts the images obtained in postoperative computerized tomography and accordingly impedes definitive interpretation of the soft structures of the brain. Although using nonresorbable and physiologically compatible thread instead of wire does eliminate the last-mentioned drawback, the fixation of the plug to the rest of the skull is still unstable. The two parts can also be fixed with thin plates of compatible metal, titanium for instance ([0003] EP A 0 510 390). Such plates bridge the abutment between the parts and are screwed to both, also closing off bores introduced into the cranium prior to section. This approach, however, is also not very satisfactory. It is both complicated and time-consuming and hence not inexpensive.
  • SUMMARY OF THE INVENTION
  • With the aforesaid state of the art as a point of departure, the object of the present invention is a simpler and more rapid device for accurate and permanent postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation. [0004]
  • This object is attained in accordance with the present invention in a device of the aforesaid genus comprising a pin and two concavoconvex disks of a physiologically compatible metal or metal compound. The pin has a flat head at one end and one of the disks comes to rest against the head. Each disk has row of teeth extending along the edge of the concave side and a bore through the center. The shaft of the pin fits into the bore. The disks can be mounted on the shaft with the teeth on each one facing the teeth on the other. The second disk can be fastened to the shaft. [0005]
  • The inner disks in the aforesaid fixation device in accordance with the present invention are secured to the pins in the vicinity of the head. The disks are then inserted through a slightly larger recess in the circumference of the plug, below the parts of the joint, with the shaft of the pin projecting out of the kerf between the plug and the rest of the cranium. The outer disk is then mounted over the section of pin projecting out of the kerf. The two disks are then approached until their teeth bite into the edges of both the plug and of the rest of the cranium. The second disk is then secured to the shaft. [0006]
  • Titanium is particularly appropriate for the physiologically compatible metal. Such titanium alloys as Ti[0007] 6A6Va are also appropriate. A device made of titanium is of advantage because it will not distort postoperative computerized- tomography images. The inner disk can be mounted more stable on the shaft of the pin if the transition between the head of the pin and the shaft is conical and dimensioned to ensure that a disk resting against the head will be forced tight around the shaft. Slits can also extend radially outward from the bore through the first disk to be mounted on the shaft. The center of the disk can be depressed. Areas can be removed from the disks at regular intervals between the bore and the edge to conserve material. The device can be applied to the two halves of bone by a procedure similar in principle to blind riveting. Notches can accordingly be introduced into each shaft to prevent the second disk mounted thereon from sliding away from the head of the pin. If the second disk on the shaft is deformed in a direction opposite that of its concavoconvexity, the deformation alone will secure it to the shaft by compression. The shaft can also be threaded and accommodate a nut. The nut can be tightened against the second disk. The second disk will in every case be displaced until its teeth engage the two halves of the joint, creating the desired fixation of the plug back into the rest of the cranium at the adjacent edges.
  • The novel device can be easily and rapidly manipulated and accomplishes the desired accurate and permanent postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation. [0008]
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • The present invention will now be specified with reference to the accompanying drawing wherein [0009]
  • FIG. 1 is an exploded view of the device in accordance with the present invention, [0010]
  • FIG. 2 is a view in the direction indicated by arrow II in FIG. 1 of one embodiment of the first disk mounted over the shaft of the pin, [0011]
  • FIG. 3 is a view in the direction indicated by arrow III in FIG. 1 of one embodiment of the second disk mounted over the shaft of the pin, [0012]
  • FIG. 4 is a longitudinal section of the components of the device assembled, [0013]
  • FIG. 5 illustrates how the device in accordance with the present invention can be employed, [0014]
  • FIG. 6 is a section along the line VI-VI in FIG. 5, [0015]
  • FIG. 7 is a schematic view and shows another embodiment of the present invention, and [0016]
  • FIG. 8 is a schematic view of a still further embodiment according to the present invention. [0017]
  • DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • A device for postoperatively fixing back into the cranium a plug of bone removed therefrom during a surgical operation comprises a [0018] pin 11 and two concavoconvex disks 21 and 22. The pin comprises a shaft 112 and a head 111, Disk 21, the inner disk, is mounted on the shaft first and comes to rest against the inner surface of the plug and of the rest of the cranium that are to be united. Disk 22, the outer disk, is mounted on the shaft next and comes to rest against the outer surface of the plug and the rest of the cranium. There is a hole 211 through the center of each disk 21 and a hole 221 through the center of each disk 22. The shaft 112 of pin 11 extends through the holes 211 and 221 of the disks in the assembled device. A raw of teeth 213 extends along the edge 212 of the concave side of disk 21, and a row of teeth 223 extends along the edge 222 of the concave side of disk 22. As will be evident from FIGS. 1 and 4, disks 21 and 22 are mounted on the shaft 112 of pin 11 with their teeth facing each other.
  • Shaft [0019] 112 fits tightly in the hole 211 through disk 21. Any disk can be provided as illustrated in FIG. 2 with slits 214 extending radially outward from the hole 211 through its center. If the transition between the head 111 and the shaft 112 of pin 11 is conical, slits 214 will as is desirable accurately position the disk in relation to the pin, both of which will accordingly support both the plug and the rest of the cranium once the device has been emplaced, The area between the hole through the center of any disk and its circumference can also be provided as illustrated in FIG. 3 with perforations 226 to conserve material and decrease weight. Each disk can have both slits 214 and perforations 226.
  • FIGS. 5 and 6 illustrate how the device is employed. FIG. 5 illustrates part of an [0020] adult cranium 31 from which a plug 32 of bone has been sawn to provide access to the brain, which is available to the surgeon through aperture 33. A recess 321 slightly larger than the disks has been removed from plug 32 at its circumference. once the operation is over, the plug is returned to the aperture 33. Inner disks 22 are mounted on the shafts 112 of pins 1. The inner disks are inserted one by one through recess 321 with the shafts projecting out and slid along the inner surface of the plug and residual cranium with the shafts extending out of kerf 331 in the directions indicated by arrows A in FIG. 5 until they arrive at the point where they are to be positioned. outer disks 22 are now mounted on the shafts of the pins in situ. The outer disks are finally secured to the shafts with a tool of the type employed to fasten blind rivets. The tool forces outer disks 22 and inner disks 21 together in the direction indicated by arrow B in FIG. 6 until the teeth on each disk bite into the tissue of the plug and of the residual cranium, securing the two together. The section of each shaft extending out beyond the outer disk is now trimmed off. The shaft can alternatively be threaded, and the disks forced together over the threads until the teeth bite into the tissue.
  • Thus, in another embodiment sown in FIG. 7, the [0021] shaft 112 of the pin 11 has notches 112 c engaging the outer surface of the second disk 22 and forcing it towards the head 111 of the pin.
  • In the embodiment of FIG. 8, the shaft of the [0022] pin 11 has a thread 112 a and accommodates a nut 112 b that can be screwed against the second disk 22.

Claims (11)

What is claimed is:
1. A device for postoperative fixation back into an opening in the cranium of a plug of bone removed therefrom during a surgical operation, wherein the plug is to be repositioned in the opening such that the space between the plug and the surrounding cranial bone is approximately the width of the kerf formed during the surgical operation and the internal and external surfaces of the plug are to be held in alignment with the adjacent internal and external surfaces of the surrounding cranial bone, the device comprising the following elements formed of a physiologically compatible substance:
a pin having a shaft that is extendable through the space between the plug and the surrounding cranial bone, the shaft having a proximal end and a distal end;
a substantially rigid first disk mounted centrally on the shaft of the pin at the proximal end, the first disk having an inner surface oriented toward the distal end of shaft and an opposite outer surface, the first disk being positionable interiorly of the opening in the cranium such that the inner surface faces the internal surface of the plug and the adjacent internal surface of the surrounding cranial bone;
a substantially rigid second disk mounted centrally on the shaft of the pin at the distal end, the second disk having a bore formed therein through which the shaft of the pin extends, an inner surface facing the first disk, and an opposite outer surface, the second disk being positionable exteriorly of the opening in the cranium such that the inner surface faces the external surface of the plug and the adjacent external surface of the surrounding cranial bone, the second disk being movable along the shaft towards the first disk from a first position wherein the first or the second disk is out of engagement with the plug and surrounding cranial bone to a second position wherein the first and second disks engage and align the internal and external surfaces of the plug and surrounding cranial bone; and
means for retaining the second disk in the second position.
2. A device in accordance with
claim 1
wherein the first disk includes teeth formed on the periphery thereof that extend toward the second disk.
3. A device in accordance with
claim 1
wherein the second disk includes teeth formed on the periphery thereof that extend toward the first disk.
4. A device in accordance with
claim 1
wherein the retaining means comprises notches formed along at least a portion of the length of the shaft of the pin, the notches restraining movement of the second disk along the shaft in the direction opposite the first disk.
5. A device in accordance with
claim 1
wherein the bore of the second disk is sized so as to fit snugly around the shaft, and said retaining means comprises frictional engagement between the second disk and the shaft.
6. A device in accordance with
claim 1
wherein the pin has a substantially flat head formed at the proximal end of the shaft, the first disk includes a bore through which the shaft extends, and the outer surface of said first disk rests against the head.
7. A device in accordance with
claim 1
wherein each of the first and second disks is concavoconvex in shape and each is oriented on the shaft such that its inner surface is the concave side.
8. A device in accordance with
claim 7
wherein each of the first and second disks is deformed in its center in a direction opposite its concavoconvexity.
9. A device as defined in
claim 1
, wherein said physiologically compatible substance is a metallic substance.
10. A device in accordance with
claim 1
, wherein said first disk includes perforations uniformly distributed within the area of said first disk between the center and the circumference of said first disk.
11. A device according to
claim 1
, wherein said second disk includes perforations uniformly distributed within the area of said second disk between the center and the circumference of said second disk.
US09/827,861 1996-02-03 2001-04-06 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation Expired - Lifetime US6328743B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US09/827,861 US6328743B2 (en) 1996-02-03 2001-04-06 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US10/011,379 US6726688B2 (en) 1996-02-03 2001-10-22 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US10/793,814 US6962591B2 (en) 1996-02-03 2004-03-08 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US11/203,271 US20060009772A1 (en) 1996-02-03 2005-08-15 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DE19603887A DE19603887C2 (en) 1996-02-03 1996-02-03 Arrangement for fixing a piece of bone that has been removed from the skull capsule for the purpose of the surgical intervention to the remaining skull leg
DE19603887 1996-02-03
DE19603887.1 1996-02-03
US08/790,071 US5800436A (en) 1996-02-03 1997-01-28 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US09/088,175 US6068631A (en) 1996-02-03 1998-06-01 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US09/494,599 US6270500B1 (en) 1996-02-03 2000-01-31 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US09/827,861 US6328743B2 (en) 1996-02-03 2001-04-06 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation

Related Parent Applications (1)

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US09/494,599 Continuation US6270500B1 (en) 1996-02-03 2000-01-31 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/011,379 Continuation US6726688B2 (en) 1996-02-03 2001-10-22 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation

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US20010011173A1 true US20010011173A1 (en) 2001-08-02
US6328743B2 US6328743B2 (en) 2001-12-11

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US08/790,071 Expired - Lifetime US5800436A (en) 1996-02-03 1997-01-28 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US09/088,175 Expired - Lifetime US6068631A (en) 1996-02-03 1998-06-01 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US09/494,599 Expired - Lifetime US6270500B1 (en) 1996-02-03 2000-01-31 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US09/827,861 Expired - Lifetime US6328743B2 (en) 1996-02-03 2001-04-06 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US10/011,379 Expired - Lifetime US6726688B2 (en) 1996-02-03 2001-10-22 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US10/793,814 Expired - Lifetime US6962591B2 (en) 1996-02-03 2004-03-08 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US11/203,271 Abandoned US20060009772A1 (en) 1996-02-03 2005-08-15 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation

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US08/790,071 Expired - Lifetime US5800436A (en) 1996-02-03 1997-01-28 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US09/088,175 Expired - Lifetime US6068631A (en) 1996-02-03 1998-06-01 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US09/494,599 Expired - Lifetime US6270500B1 (en) 1996-02-03 2000-01-31 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation

Family Applications After (3)

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US10/011,379 Expired - Lifetime US6726688B2 (en) 1996-02-03 2001-10-22 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US10/793,814 Expired - Lifetime US6962591B2 (en) 1996-02-03 2004-03-08 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US11/203,271 Abandoned US20060009772A1 (en) 1996-02-03 2005-08-15 Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation

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US (7) US5800436A (en)
EP (2) EP0787466B1 (en)
JP (1) JP3011896B2 (en)
DE (3) DE19603887C2 (en)
ES (2) ES2217627T3 (en)

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DE19603887A1 (en) 1997-08-14
DE59711473D1 (en) 2004-05-06
EP0787466B1 (en) 1999-11-03
US6068631A (en) 2000-05-30
US6726688B2 (en) 2004-04-27
US6962591B2 (en) 2005-11-08
ES2140156T3 (en) 2000-02-16
US5800436A (en) 1998-09-01
DE19603887C2 (en) 1998-07-02
US6270500B1 (en) 2001-08-07
ES2217627T3 (en) 2004-11-01
EP0787466A1 (en) 1997-08-06
EP0920837A2 (en) 1999-06-09
DE59700637D1 (en) 1999-12-09
JPH09206311A (en) 1997-08-12
US20020040224A1 (en) 2002-04-04
EP0920837B1 (en) 2004-03-31
US20060009772A1 (en) 2006-01-12
US6328743B2 (en) 2001-12-11
EP0920837A3 (en) 1999-07-28
JP3011896B2 (en) 2000-02-21
US20040172029A1 (en) 2004-09-02

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