US20010053846A1 - Preparation method of arbutin intermediates - Google Patents
Preparation method of arbutin intermediates Download PDFInfo
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- US20010053846A1 US20010053846A1 US09/838,841 US83884101A US2001053846A1 US 20010053846 A1 US20010053846 A1 US 20010053846A1 US 83884101 A US83884101 A US 83884101A US 2001053846 A1 US2001053846 A1 US 2001053846A1
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- chemical formula
- pentaacetyl
- hydroquinone
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- mixture
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- 0 *OC1=CC=C(O)C=C1.*OC1=CC=C(OC2O[C@H](CO[Ac])C(O[Ac])C(O[Ac])C2O[Ac])C=C1.C.II.[Ac]OC[C@H]1OC(O[Ac])C(O[Ac])C(O[Ac])C1O[Ac] Chemical compound *OC1=CC=C(O)C=C1.*OC1=CC=C(OC2O[C@H](CO[Ac])C(O[Ac])C(O[Ac])C2O[Ac])C=C1.C.II.[Ac]OC[C@H]1OC(O[Ac])C(O[Ac])C(O[Ac])C1O[Ac] 0.000 description 7
- LPTITAGPBXDDGR-IBEHDNSVSA-N CC(OC[C@H]([C@H]([C@@H]([C@H]1OC(C)=O)OC(C)=O)OC(C)=O)O[C@H]1OC(C)=O)=O Chemical compound CC(OC[C@H]([C@H]([C@@H]([C@H]1OC(C)=O)OC(C)=O)OC(C)=O)O[C@H]1OC(C)=O)=O LPTITAGPBXDDGR-IBEHDNSVSA-N 0.000 description 1
- UMISXELBJDPKSF-CGGAZBBHSA-M CC1=CC=C(OC2O[C@H](CO[Ac])C(O[Ac])C(O[Ac])C2O[Ac])C=C1.OC[C@H]1O[C@@H](OC2=CC=C(O)C=C2)[C@H](O)[C@@H](O)[C@@H]1O.[V].[V]I Chemical compound CC1=CC=C(OC2O[C@H](CO[Ac])C(O[Ac])C(O[Ac])C2O[Ac])C=C1.OC[C@H]1O[C@@H](OC2=CC=C(O)C=C2)[C@H](O)[C@@H](O)[C@@H]1O.[V].[V]I UMISXELBJDPKSF-CGGAZBBHSA-M 0.000 description 1
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1Oc(cc1)ccc1O Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1Oc(cc1)ccc1O BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 1
- BYPPUGQXDRUMCS-CEPAHGKDSA-M OC[C@H]1O[C@@H](OC2=CC=C(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C=C2)[C@H](O)[C@@H](O)[C@@H]1O.[Ac]OC[C@H]1OC(OC2=CC=C(O[Ac])C=C2)C(O[Ac])C(O[Ac])C1O[Ac] Chemical compound OC[C@H]1O[C@@H](OC2=CC=C(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C=C2)[C@H](O)[C@@H](O)[C@@H]1O.[Ac]OC[C@H]1OC(OC2=CC=C(O[Ac])C=C2)C(O[Ac])C(O[Ac])C1O[Ac] BYPPUGQXDRUMCS-CEPAHGKDSA-M 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
Definitions
- pentaacetylarbutin which is a key intermediate in the synthesis of arbutin.
- pentaacetylarbutin can be prepared by new and stereoselective ⁇ -O-glycosylation of hydroquinone or monoprotected hydroquinone with pentaacetyl- ⁇ -D-glucose in the presence of BF 3 ⁇ Et 2 O and base.
- Arbutin is a natural product extracted from leaves of blueberry and has been used as a stabilizer for color photographic image, a diuretic (Merck Index: 12 th ed. p 816) and recently, a whitening agent in cosmetics (K. Maeda et al. The Journal of Pharmacology and Experimental Therapeutics, 276, 765-769, 1996). Three kinds of preparative methods of arbutin have been reported; 1) extraction from plants, 2) plant cell culture, 3) organic synthesis. The first method seems to be limited to production on a small scale because of the lack of resources.
- Arbutin has been prepared by deprotection of variously protected arbutins.
- Variously protected arbutins were prepared by ⁇ -O-glycosylation of hydroquinone or monoprotected hydroquinones with pentaacetyl- ⁇ -D-glucose.
- Reaction (1) shows a synthesis of arbutin (V).
- Reaction (2) represents the preparation of pentaacetylarbutin (chemical formula VIII) (Japanese patent: JP sho62-263195).
- pentaacetyl- ⁇ -D-glucose chemical formula III
- hydroquinone chemical formula VI
- acetic acid is removed by vacuum distillation (15 mmHg) which is prepared as a side product.
- Pentaacetylarbutin which has excellent recrystalization property is obtained by acetylation with acetic anhydride in one-pot reaction without separation of tetraacetylarbutin.
- reaction formular (2) As shown in reaction formula (2), during the reaction of pentaacetyl- ⁇ -D-glucose with hydroquinone, octaacetyl diglucosyl hydroquinone(chemical formula X) is obtained as a side product. Diacetylhydroquinone (chemical formula IX) is also produced during acetylation due to the use of excess hydroquinone. The side product, octaacetyl diglucosyl hydroquinone cannot be separated completely during the purification of pentaacetyl- ⁇ -D-arbutin.
- the purpose of present invention is to resolve the problems.
- This invention will provide a new and ⁇ -stereoselective glycosylation of mono-protected hydroquinone with pentaacetyl- ⁇ -D-glucose for the preparation of pentaacetylarbutin in high yield.
- R is hydrogen, alkyl group or cycloalkyl group with 1 to 10 carbon, or aliphatic or aromatic acyl group with 1 to 10 carbon.
- Lewis acid tin tetrachloride, boron trifluoride etherate, boron trichloride, zinc chloride, ferric chloride, trimethylsilyl trifluoromethane sulfonate, or their mixture can be used and boron trifluoride etherate is advantageous.
- the amount of Lewis acid is 0.1 to 4 molar equivalent to pentaacetylglucose, and, 1 to 2 equivalent is desirable.
- Organic base such as triethylamine, tributylamine, pyridine or lutidine and inorganic base such as potassium carbonate or sodium carbonate, or their mixture can be used for base.
- the amount should be used is 0.1 to 4 equivalent weight, and 0.5-2 equivalent molar weight is proper.
- reaction temperature is from room temperature to 100 C. and from room temperature to 40 C. is desirable.
- the invention has following advantages over the previous methods of arbutin synthesis.
Abstract
The invention is related to a preparation method of arbutin intermediate (chemical formula I). It is characterized by the glycosylation of hydroquinone or mono-protectected hydroquinone (chemical formula II) with pentaacetyl-β-D-glucose (chemical formula III) in the presence of Lewis acid and base as catalysts.
where Ac is acetyl group, R is hydrogen, alkyl or cycloalkyl group with 1 to 10 carbon, or aliphatic or aromatic acyl group with 1 to 10 carbon.
Description
- This invention is related to a preparation method of pentaacetylarbutin which is a key intermediate in the synthesis of arbutin. In detail, pentaacetylarbutin can be prepared by new and stereoselective β-O-glycosylation of hydroquinone or monoprotected hydroquinone with pentaacetyl-β-D-glucose in the presence of BF 3·Et2O and base.
- Arbutin is a natural product extracted from leaves of blueberry and has been used as a stabilizer for color photographic image, a diuretic (Merck Index: 12 th ed. p 816) and recently, a whitening agent in cosmetics (K. Maeda et al. The Journal of Pharmacology and Experimental Therapeutics, 276, 765-769, 1996). Three kinds of preparative methods of arbutin have been reported; 1) extraction from plants, 2) plant cell culture, 3) organic synthesis. The first method seems to be limited to production on a small scale because of the lack of resources.
- The second one has been reported by many authors since 1990 (Japanese patents: JP hesei1-269498, JP hesei4-131091, JP hesei5-176785, Helv. Chim. Acta. 2009, 75, 1992), however, hasn't been developed yet for mass production.
- The third one is the general preparation method in industry. Arbutin has been prepared by deprotection of variously protected arbutins. Variously protected arbutins were prepared by β-O-glycosylation of hydroquinone or monoprotected hydroquinones with pentaacetyl-β-D-glucose.
- Reaction (1) shows a synthesis of arbutin (V).
- where Ac is acetyl group and R′ is acetyl or benzyl group.
- The general preparation methods of arbutin were the deprotection of benzyl teteracetylarbutin (R′=benzyl, U.S. Pat. No. 3,201,385) or pentaacetylarbutin (R″=acetyl, JP: sho62-226974) as shown in reaction (1). Because pentaacetylarbutin has only one kind of protecting group, only one step of deprotection was needed in order to obtain arbutin. However, for benzyl tetraacetylarbutin, two steps of deprotecting reaction are required and during debenzylation step, hydrogen gas was used which is dangerous due to the risk of explosion.
- Reaction (2) represents the preparation of pentaacetylarbutin (chemical formula VIII) (Japanese patent: JP sho62-263195). During the reaction of pentaacetyl-β-D-glucose (chemical formula III) with hydroquinone (chemical formula VI) in the presence of p-toluenesulfonic acid as a catalyst, acetic acid is removed by vacuum distillation (15 mmHg) which is prepared as a side product. Pentaacetylarbutin which has excellent recrystalization property is obtained by acetylation with acetic anhydride in one-pot reaction without separation of tetraacetylarbutin.
- where Ac is acetyl group.
- As shown in reaction formular (2), during the reaction of pentaacetyl-β-D-glucose with hydroquinone, octaacetyl diglucosyl hydroquinone(chemical formula X) is obtained as a side product. Diacetylhydroquinone (chemical formula IX) is also produced during acetylation due to the use of excess hydroquinone. The side product, octaacetyl diglucosyl hydroquinone cannot be separated completely during the purification of pentaacetyl-β-D-arbutin. Additionally, during the preparation of arbutin by the solvolysis of pentaacetyl-β-D-arbutine, diglucosyl hydroquinone (chemical formula XI) remains in product as an impurity owing to similar properties with arbutin
- Therefore, the purpose of present invention is to resolve the problems. This invention will provide a new and β-stereoselective glycosylation of mono-protected hydroquinone with pentaacetyl-β-D-glucose for the preparation of pentaacetylarbutin in high yield.
- The purpose of this invention mentioned above can be achieved by new and stereoselective glycosylation of hydroquinone or monoprotected hydroquinones (chemical formula II) with pentaacetyl-β-D-glucose (chemical formula III) in the presence of Lewis acid and base as shown in reaction (3).
- where Ac is acetyl group, R is hydrogen, alkyl group or cycloalkyl group with 1 to 10 carbon, or aliphatic or aromatic acyl group with 1 to 10 carbon.
- For a Lewis acid, tin tetrachloride, boron trifluoride etherate, boron trichloride, zinc chloride, ferric chloride, trimethylsilyl trifluoromethane sulfonate, or their mixture can be used and boron trifluoride etherate is advantageous. The amount of Lewis acid is 0.1 to 4 molar equivalent to pentaacetylglucose, and, 1 to 2 equivalent is desirable.
- Organic base such as triethylamine, tributylamine, pyridine or lutidine and inorganic base such as potassium carbonate or sodium carbonate, or their mixture can be used for base. The amount should be used is 0.1 to 4 equivalent weight, and 0.5-2 equivalent molar weight is proper.
- For solvent, toluene, benzene, xylene, dichloromethane, dichloroethane, chloroform, acetone, acetonitrile or their mixture also can be used. Reaction temperature is from room temperature to 100 C. and from room temperature to 40 C. is desirable.
- The invention has following advantages over the previous methods of arbutin synthesis.
- 1) the absence of octaacetyldiglucosyl hydroquinone
- 2) minimum production of pentaacetyl-α-D-arbutin
- 3) high yield (more than 90%) of pentaacetyl-β-D-arbutin (chemical formula I) or tetraacetyl-β-D-arbutin with mono-protecting group.
- The following examples describe the invention in detail. They are just for explaining the invention and the extent of the patent is not limited to them.
- Preparation of pentaacetylarbutine
- Under the stream of nitrogen, pentaacetyl-β-D-glucose (78 g, 0.2 mol), monoacetyhydroquinone (45.6 g, 0.3 mol), dried methylene chloride (140 ml), and 22.4 g of triethylamine (0.22 mol) was placed in a 500 ml flask. Borontrifluoride diethyletherate (56 g, 0.4 mol) was added dropwise to the mixture for 30 min. After addition, the reaction mixture was kept 30-50° C. for 18 hours. After the reaction was terminated, 200 ml of water was added and the organic layer was separated. Organic layer was washed with water (100 ml), dried over MgSO 4 and evaporated to dryness in vacuum evaporator. The dry residue was recrystalized with methanol to give pentaacetylarbutin. Yield: 87.7 g (91%). mp: 139-140 C. 1H-NMR(300 MHz, CDCl3, ppm) 2.03 (s, 3H), 2.04 (s, 3H), 2.06 (s, 3H), 2.07 (s, 3H), 2.28 (s, 3H), 3.81-3.86 (m,1H), 4.17-4.29 (m,1H), 4.13-4.18 (m,1H), 4.26-4.31 (m,1H), 5.03 (d,1H), 5.16 (t,1H), 5.25-5.29 (m,2H).
- Preparation of benzyltetraacetylarbutin
- Under the stream of nitrogen, pentaacetyl-p-D-glucose (78 g, 0.2 mol), monobenzyl hydroquinone (60.1 g, 0.3 mol), dried methylene chloride (140 ml), and 22.4 g of triethylamine (0.22 mol) was placed in a 500 ml flask. Borontrifluoride diethyletherate (56 g, 0.4 mol) was added dropwise to the mixture for 30 min. After addition, the reaction mixture was kept 30-50° C. for 18 hours. After the reaction was terminated, 200 ml of water was added and the organic layer was separated. Organic layer was washed with water (100 ml), dried over MgSO 4 and evaporated to dryness in vacuum evaporator. The dry residue was recrystalized with methanol to give benzyl tetraacetylarbutin. Yield: 88.2 g (90%). mp: 111-112° C. 1H-NMR(300 MHz, CDCl3, ppm) 2.03 (s, 1H), 2.04 (s, 3H), 2.07 (s, 6H), 3.73-3.84 (m, 1H), 4.12-4.21 (m, 1H), 4.22-4.37 (m, 1H), 4.93 (d, 1H), 5.03 (s, 2H), 5.07-5.29 (m, 2H), 6.03-6.95 (m, 4H), 7.28-7.48 (m, 5H).
- Preparation of benzoyl tetraacetylarbutin
- Under the stream of nitrogen, pentaacetyl-β-D-glucose (78 g, 0.2 mol), monobenzoyl hydroquinone (64.2 g, 0.3 mol), dried methylene chloride (140 ml), and 22.4 g of triethylamine (0.22 mol) was placed in a 500 ml flask. Borontrifluoride diethyletherate (56 g, 0.4 mol) was added dropwise to the mixture for 30 min. After addition, the reaction mixture was kept 30-50° C. for 18 hours. After the reaction was terminated, 200 ml of water was added and the organic layer was separated. Organic layer was washed with water (100 ml), dried over MgSO 4 and evaporated to dryness in vacuum evaporator. The dry residue was recrystalized with methanol to give benzoyl tetraacetylarbutin. Yield: 88.3 g (90%). mp: 136-138 C. 1H-NMR(300 MHz, CDCl3, ppm) 2.04 (s, 3H), 2.05 (s, 3H), 2.08 (s, 6H), 3.73-3.84 (m, 1H), 4.12-4.21 (m, 1H), 4.22-4.37 (m, 1H), 5.02-5.38 (m, 3H), 7.42-7.68 (m, 4H), 8.04-8.22 (m, 2H).
Claims (8)
1. A preparation method of pentaacetyl-β-D-arbutine or tetraacetyl-β-D-arbutine with mono-protecting group (chemical formula I) by the β-stereoselective glycosylation of hydroquinone or mono-protected hydroquinone (chemical formula II) with pentaacetyl-β-D -glucose (chemical formula III) in the presence of Lewis acid and base as reaction catalysts.
where R is hydrogen, alkyl or cycloalkyl group with 1 to 10 carbon, or aliphatic or aromatic acyl group with 1 to 10 carbon.
2. The method of , wherein said R is acetyl, benzyl, or benzoyl goup
claim 1
3. The method of ,wherein said reaction is continued for 3 to72 hours at temperature of 20 to 100° C. in the presence of an organic solvent.
claim 1
4. The method of , wherein said organic solvent is toluene, benzene, xylene, dichloromethane, dichloroethane, chloroform, acetone, acetonitrile, or their mixture.
claim 3
5. The method of claim1, wherein said Lewis acid is tin tetrachloride, boron trifluoride, boron trichloride, zinc chloride, ferric trichloride, trimethylsilyltrifluoromentanesulfonate, or their mixture.
6. The method of claim5, wherein the amount of said Lewis acid used is 1.0 to 4 molar equivalent to pentaacetyl-β-D-glucose.
7. The method of claim1, wherein said base is organic base such as triethylamine, tributylamine, pyridine or lutidine, and inorganic salt such as potassium carbonate or sodium carbonate, or their mixture
8. The method of , wherein the amount of said base used is 0.01 to 4.0 molar equivalent to β-D-pentaacetylglucose
claim 7
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020000027129A KR100365020B1 (en) | 2000-05-19 | 2000-05-19 | Preparation method of arbutin intermediats |
| KR2000-27129 | 2000-05-19 |
Publications (2)
| Publication Number | Publication Date |
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| US20010053846A1 true US20010053846A1 (en) | 2001-12-20 |
| US6388103B2 US6388103B2 (en) | 2002-05-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| US09/838,841 Expired - Lifetime US6388103B2 (en) | 2000-05-19 | 2001-04-20 | Preparation method of arbutin intermediates |
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| Country | Link |
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| US (1) | US6388103B2 (en) |
| KR (1) | KR100365020B1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103159805A (en) * | 2011-12-14 | 2013-06-19 | 南京华狮化工有限公司 | Method for synthesis of alpha-arbutin |
| CN103524575A (en) * | 2013-05-24 | 2014-01-22 | 湖北阿泰克糖化学有限公司 | Improved beta-arbutin preparation method |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100449317B1 (en) * | 2001-06-14 | 2004-09-18 | 주식회사 엔지켐 | Process for the preparation of arbutin derivatives |
| US7056742B2 (en) * | 2003-06-16 | 2006-06-06 | E. I. Du Pont De Nemours And Company | High Level production of arbutin in green plants |
| ES2627984T3 (en) | 2012-09-14 | 2017-08-01 | Claride Pharma S.R.L. | Composition for the prevention and treatment of acute and recurrent urinary tract infections |
| CN110903333A (en) * | 2019-12-30 | 2020-03-24 | 陕西岳达德馨生物制药有限公司 | Preparation method of glucoside and derivatives thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3201385A (en) | 1963-02-11 | 1965-08-17 | Polaroid Corp | Synthesis of arbutin |
| JPS52113929A (en) * | 1976-03-19 | 1977-09-24 | Shionogi & Co Ltd | Glucoside derivatives |
| JPH0745489B2 (en) | 1986-03-28 | 1995-05-17 | 三井石油化学工業株式会社 | Method for producing tetrahydropyran derivative |
| JPH0689016B2 (en) * | 1986-05-09 | 1994-11-09 | 日本精化株式会社 | Method for producing pentaacetylarbutin |
| JPH0689015B2 (en) * | 1986-05-09 | 1994-11-09 | 日本精化株式会社 | Method for producing tetraacetylarbutin |
| KR940001780B1 (en) * | 1991-09-26 | 1994-03-05 | 금호석유화학 주식회사 | Process for preparation of 2-(2-hydroxy-3-t-butyl-5-alkylphenyl)-5-cloro benzotrizol |
| EP1043321A1 (en) * | 1999-03-29 | 2000-10-11 | Nisshin Flour Milling Co., Ltd. | Process for the preparation of tetrahydropyran derivatives |
-
2000
- 2000-05-19 KR KR1020000027129A patent/KR100365020B1/en active Pre-grant Review Request
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2001
- 2001-04-20 US US09/838,841 patent/US6388103B2/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103159805A (en) * | 2011-12-14 | 2013-06-19 | 南京华狮化工有限公司 | Method for synthesis of alpha-arbutin |
| CN103524575A (en) * | 2013-05-24 | 2014-01-22 | 湖北阿泰克糖化学有限公司 | Improved beta-arbutin preparation method |
Also Published As
| Publication number | Publication date |
|---|---|
| US6388103B2 (en) | 2002-05-14 |
| KR20010105119A (en) | 2001-11-28 |
| KR100365020B1 (en) | 2002-12-16 |
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