A holder for releasedly retaining a sharps instrument repeatedly used during a medical procedure. The holder has a support component to support the sharps instrument and a guard component to isolate a sharp tip of the instrument and thereby prevent an inadvertent invasive contact to a care provider. Preferably, at least a portion of the support component is generally complimentary in shape to the sharps instrument, and non-limitedly can be chosen from a generally U-shape cradle or a diametrically diminishing hollow tube wherein the instrument is accommodated during retention. Guard component choices non-limitedly include a replaceable non-coreable wall penetrable by a sharp tip and situated to accept a sharp tip when the sharps instrument is stored, or a holder-housing portion disposed distally from and proximate the instrument support component and within which the sharp tip resides when the instrument is stored. It is preferred that the holder can simultaneously accommodate a plurality of sharps instruments such that a care provider can safely and efficiently retrieve and replace instruments as necessary in the administration of treatment utilizing the instruments.