Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.

Patents

  1. Advanced Patent Search
Publication numberUS20020045916 A1
Publication typeApplication
Application numberUS 09/887,978
Publication dateApr 18, 2002
Filing dateJun 22, 2001
Priority dateDec 6, 1999
Also published asUS6461370, US7862577, US7931664, US7996993, US20030074019, US20050177187, US20070123932, US20070126161
Publication number09887978, 887978, US 2002/0045916 A1, US 2002/045916 A1, US 20020045916 A1, US 20020045916A1, US 2002045916 A1, US 2002045916A1, US-A1-20020045916, US-A1-2002045916, US2002/0045916A1, US2002/045916A1, US20020045916 A1, US20020045916A1, US2002045916 A1, US2002045916A1
InventorsWilliam Gray, Richard Gambale
Original AssigneeC.R. Bard, Inc.
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Temporary vascular filter guide wire
US 20020045916 A1
Abstract
A temporary filter is described for use in percutaneous intravascular procedures for the treatment of diseased blood vessels, such as angioplasty or stent placement procedures. The guide wire which is used to direct a catheter (such as a balloon catheter) to a treatment site contains a deployable filter. The guide wire is moveable independently of the catheter and can be used to position the filter at a desired location downstream of the treatment site. The guide wire includes parts moveable with respect to each other and the filter is connected to these parts in such a way that it can be deployed and collapsed by relative movement of the parts.
Images(9)
Previous page
Next page
Claims(32)
What is claimed is:
1. A vascular filter guide wire for directing placement of a catheter with respect to a blood vessel lesion and filtering particulate matter dislodged by treatment of said vessel, said guide wire including:
an elongated flexible core wire having a proximal end and a distal end for insertion and steerage through a patient's vasculature to a position downstream of said lesion;
a tubular flexible shaft slidably disposed along said core wire, said shaft including a proximal portion and a distal portion disposed proximally of said core wire distal end for placement downstream of said lesion; and
a collapsible filter coupled at its proximal end to said distal portion of said shaft and at its distal end to said core wire, said filter operable in response to the relative is displacement between said shaft and said core wire to radially extend outwardly within said vasculature and trap particulate matter arising from the treatment of said lesion.
2. A vascular filter guide wire according to claim 1 and further including:
a locking mechanism to maintain said filter in a deployed position for particulate filtration during lesion treatment.
3. A vascular filter guide wire according to claim 1 wherein:
said core wire includes a filter housing for confining said filter in a closed configuration.
4. A vascular filter guide wire according to claim 3 wherein:
said housing is formed in a frusto-conical configuration and axially disposed on said core wire, said housing including an oversized-in-diameter mouth opening axially outwardly from said wire distal end, and a reduced-in-diameter collar radially fixed to said core wire proximate said distal end.
5. A vascular filter guide wire according to claim 3 wherein said strainer is formed to collapsibly engage said housing in a closed state and including:
a plurality of radially spaced apart support struts defining a cage, said struts collapsibly hinged at one end along a common radial path on said shaft and interconnected through a woven peripheral mesh; and
a biasing element interposed concentrically between said struts and said shaft to bias said struts radially outwardly in an open state.
6. A vascular filter guide wire according to claim 5 wherein:
said spaced apart struts are disposed radially equidistant.
7. A vascular filter guide wire according to claim 5 wherein:
said spaced apart struts are disposed in a spiral relationship.
8. A vascular filter guide wire according to claim 5 wherein:
said struts are formed of a high elastic material.
9. A vascular filter guide wire according to claim 5 wherein:
said woven mesh comprises a polymeric material.
10. A vascular filter guide wire according to claim 5 wherein:
said woven mesh density is in the range 40 to 500 micrometers.
11. A vascular filter guide wire according to claim 5 wherein:
said biasing element comprises a quad filar spring.
12. A vascular filter guide wire according to claim 1, further including a deployment/retraction mechanism including:
a removable base formed with a threaded passage for confining the proximal portion of said shaft; and
a manually rotatable control element, said control element formed with a threaded hollow shank and mounted to the proximal end of said wire, said control element operable to threadably engage said passage and incrementally urge relative axial displacement between said shaft and said wire to extend and retract said filter.
13. A vascular filter guide wire according to claim 1 wherein said filter includes:
a cylindrical support cage having a closed distal end and a flared proximal end, said distal end fixed to the distal extremity of said shaft, and said proximal end extending axially and mounted to said core wire distal end; and
a continuous woven mesh having a plurality of longitudinal pleats and disposed within said support cage for straining particulate matter.
14. A vascular filter guide wire according to claim 13 wherein:
said filter is formed with oppositely disposed cone-shaped ends to define said front and back halves.
15. A vascular filter guide wire according to claim 14 wherein
said woven mesh is mounted to said cage back half.
16. A vascular filter guide wire according to claim 13 wherein:
said woven mesh comprises a material from the group including stainless steel and nickel-titanium alloy.
17. A vascular filter guide wire according to claim 13 wherein:
said wire mesh density is in the range 40 to 500 micrometers.
18. A vascular filter guide wire according to claim 1 wherein said filter includes:
a braid comprising a composite metallic/polymeric material, said material including
a plurality of metallic filaments mounted to said respective shiftable shaft and core wire to define a support structure and
a polymeric mesh interwoven with said metallic filaments to define a strainer.
19. A vascular filter guide wire according to claim 18 wherein:
a said metallic filaments have respective common proximal and distal halves; and
said polymeric mesh is interwoven in said distal half of said metallic filaments.
20. A vascular filter guide wire according to claim 18 wherein:
said metallic and polymeric filaments are woven at a ratio of approximately 1:4.
21. A vascular filter guide wire for directing precision placement of a catheter with respect to a lesion and filtering particulate matter dislodged by treatment of said lesion, said guide wire including:
an actuating mechanism;
an elongated flexible core wire having a proximal end attached to said actuating mechanism and a distal end for insertion and steerage through a patient's vasculature to a position downstream of said lesion;
a tubular flexible shaft slidably disposed along said core wire, said shaft including a proximal portion affixed to said actuating mechanism in movable relation to said wire, and a distal portion disposed inwardly from the distal end of said core wire for placement downstream of said lesion;
a locking mechanism to maintain said filter in an extended position during lesion treatment; and
a collapsible filter coupled to said shaft distal portion, said filter including a collapsible support cage having respective front and back halves for slidably extending and retracting axially along said wire, said cage having a first end fixed to the distal extremity of said shaft, and an opposite end mounted to said core wire distal end, said strainer further including a continuous woven mesh disposed within said support cage for straining particulate matter and operable, in response to manual manipulation of said actuating mechanism to effect relative displacement between said shaft and said core wire, to radially extend outwardly within said vasculature and trap particulate matter arising from the treatment of said lesion.
22. A catheter system for treating a blood vessel lesion within a vasculature, said catheter system including:
a catheter having a lesion treatment device; and
a vascular filter guide wire for directing said balloon catheter to said lesion, said guide wire including a collapsible filter for manual deployment downstream of said balloon catheter to trap particulate matter arising from the treatment of said lesion.
23. A catheter system according to claim 22 wherein said vascular filter guide wire includes:
an elongated flexible core wire having a proximal end and a distal end for insertion and steerage through a patient's vasculature to a position downstream of said lesion;
a tubular flexible shaft slidably disposed along said core wire, said shaft including a proximal portion and a distal portion disposed inwardly from said core wire distal end for placement downstream of said lesion; and
a collapsible filter coupled at one end to said shaft and at its other end to said core wire, said filter operable in response to relative displacement between said shaft and said core wire, to radially extend outwardly within said vasculature and trap particulate matter arising from the treatment of said lesion.
24. A method of filtering particulate debris from a vasculature caused by treatment of a lesion with a lesion treatment device, said catheter guided to the location of said lesion by a vascular filter guide wire having a core wire, a slidable shaft, and a manually collapsible filter mounted on the shaft and deployable upon relative displacement between said core wire and said shaft, said method including the steps of:
guiding said vascular filter guide wire through said vasculature along a predetermined path to a lesion such that said filter is disposed downstream of said lesion;
deploying said filter radially outwardly by shifting said shaft relative to said core wire;
running said catheter over said guide wire along said predetermined path to position said lesion treatment device proximate said lesion;
treating said lesion according to a predetermined procedure;
maintaining said filter in a deployed position to trap particulate matter dislodged during said lesion treatment and prevent said matter from progressing downstream;
withdrawing said catheter from said vasculature;
retracting said filter radially inwardly by shifting said shaft back to said original position; and
removing said guide wire from said vasculature.
25. A vascular filter for controllably expanding within a blood vessel to trap particulate matter loosened from a lesion, said filter responsive to relatively shiftable control elements to expand and retract, said filter including:
a braid comprising a composite metallic/polymeric material, said material including a plurality of metallic filaments mounted to said respective shiftable shaft and core wire to define a support structure, and
a polymeric mesh interwoven with said metallic filaments to define a strainer.
26. A vascular filter guide wire according to claim 25 wherein:
said metallic filaments have respective common proximal and distal halves; and
said polymeric mesh is interwoven in said distal half of said metallic filaments.
27. A vascular filter guide wire according to claim 25 wherein:
said metallic and polymeric filaments are woven at a ratio of approximately 1:4.
28. A method of fabricating a vascular filter, said method including the steps of:
selecting a mandrel having a plurality of consecutively connected forms;
weaving a continuous layer of braid over said consecutively connected forms;
bonding said braid filaments at spaced apart sections between respective forms;
separating said respective braided forms at said bonded sections; and
removing said forms from said layer of braid.
29. A method of fabricating a vascular filter according to claim 28 wherein said step of weaving includes:
forming a layer of braid over the proximal and distal halves of each form with a composite metallic/polymeric material to having a pic density sufficient to strain particulate matter.
30. A method of fabricating a vascular filter according to claim 29 and further including the step of:
cutting said polymeric filaments from said proximal halves of each form; and
fusing the ends of said cut filaments to form a collection cavity around each form.
31. A method of fabricating a vascular filter according to claim 28 wherein after said bonding step, said method further includes the steps of:
installing a filter layer over each form;
weaving a second continuous layer of braid having a plurality of second braid filaments over said installed filters; and
bonding said second braid filaments at said spaced apart sections.
32. A method of fabricating a vascular filter according to claim 28 wherein said forms are molded from a dissolvable material, said step of removing including:
dissolving said forms by an appropriate solvent.
Description
    FIELD OF THE INVENTION
  • [0001]
    The invention relates to vascular filters intended to capture embolic particles, by means of filtration, that may arise from the treatment of diseased blood vessels.
  • BACKGROUND OF THE INVENTION
  • [0002]
    Percutaneous intravascular treatment of diseased blood vessels, such as angioplasty or stent placement procedures, may result in the dislodgment of loose plaque or thrombus which then migrate downstream. Since any such particles may become lodged in other vessels, effectively preventing blood from passing into the organ which that vessel supplies, and potentially causing serious end-organ damage which may be difficult or impossible to reverse, effective avoidance of this complication is extremely important.
  • [0003]
    One of the early methods of removing residual matter resulting from an angioplasty procedure using a balloon catheter involved maintaining the balloon in an inflated state while performing the intended intervention on the blood vessel. In this manner, much of the material could be removed without an extraneous filtering device. However, the reliability of such a procedure, especially for blood vessels supplying oxygen to the brain, necessitated substantial improvement.
  • [0004]
    Previous attempts at vascular filters have included a vena caval filter, which is permanently deployed in the vena cava via a peripheral vein in order to prevent embolisation of blood clots from the veins of the legs to the lungs, thus avoiding potentially serious and life threatening pulmonary embolism. The filter typically included a plurality of anchoring legs bent outwardly to form hooks to penetrate the vessel wall and secure the filter permanently in position. An example of such a device is disclosed in U.S. Pat. No. 4,619,246.
  • [0005]
    While conventional vena caval filters work well for their intended purposes, they suffer from the disadvantages associated with damaging the inner vessel wall through the inherent penetrating nature of the hooks, and blockage caused over time as the filter becomes endothelialized with the blood vessel inner wall or as recurrent blood clots obstruct blood 5 flow through the filter.
  • [0006]
    In an effort to resolve the problems with vena caval filters, those skilled in the art have developed temporary filtering mechanisms that attach to an angioplasty catheter and withdraw from the vasculature following the procedure. One proposal, disclosed in U.S. Pat. No. 4,723,549, discloses a collapsible wire mesh filter disposed around the distal portion of a wire guided balloon catheter. A filter balloon is positioned beneath the wire mesh and inflates radially outwardly to expand the wire mesh when inserted downstream of a stenosed blood vessel. As the vessel is treated, fine particles dislodged from the stenosis are trapped by the mesh and subsequently removed with the filter and catheter following the procedure.
  • [0007]
    A similar device and method, disclosed in U.S. Pat. No. 4,873,978 includes a balloon catheter directed through a vasculature by a guide wire. The catheter mounts a strainer at its distal end that responds to actuation of a separate control wire to open and close a plurality of tines capable of retaining dislodged particles from a treated stenosis.
  • [0008]
    The temporary filter devices described above require additional lumens and/or control wires beyond those associated with the catheter guide wire to control the filtering procedure. The extra lines and wires typically create added complexity for the operator. Moreover, it is often desirable to adjust the relative spacing between the deployed filter and the stenosed area due to the potential presence of additional blood vessels proximate the stenosis. Because the conventional filters are mounted to the distal ends of the respective catheters, adjustments during the procedure typically cannot be made. Furthermore, the use of balloon catheters and stent devices involving the same procedure could not be achieved with filter protection in place.
  • [0009]
    Therefore, a need exists in the art for a temporary vascular filter which does not require additional control wires and catheter lumens. Moreover, the need exists for such a filter in which adjustment of the filter with respect to a lesioned vessel area, and allows for the exchange of various types of devices (e.g., balloon catheters, stents, etc.), while maintaining protection against distal emboli. The temporary vascular filter guide wire of the present invention satisfies these needs.
  • SUMMARY OF THE INVENTION
  • [0010]
    The apparatus and method of the present invention minimizes the complexity associated with manipulating a vascular filter during an angioplasty or stent placement procedure by incorporating the filter on a catheter guide wire such that the guide wire performs the dual functions of guiding the catheter to a stenosed location, and filtering dislodged particles flowing downstream of the treated area. Moreover, because the guide wire operates independently of the catheter, relative spacing between the filter and the lesion location may be easily altered, and exchanges of various devices over the wire are possible.
  • [0011]
    To realize the advantages described above, the invention, in one form, comprises a vascular filter guide wire for directing precision placement of a catheter or stent proximate a lesion and selectively filtering particulate debris dislodged by treatment. The guide wire includes an actuating mechanism and an elongated flexible core wire having a proximal end mounted to the actuating mechanism and a distal end for insertion through a vasculature to a position downstream of the lesion. A tubular flexible shaft is slidably disposed telescopically along the core wire. The shaft includes a proximal portion affixed to the actuating mechanism in movable relation to the wire proximal end, and a distal portion disposed inwardly from the core wire distal end for placement downstream of the lesion. A collapsible strainer coupled to the shaft distal portion is operable, in response to relative displacement between the shaft and the core wire, to radially extend outwardly within the vasculature so that it can trap particulate matter arising from the treatment of the lesion.
  • [0012]
    In another form, the invention comprises a catheter system for treating a lesion within the vasculature. The catheter system includes a catheter having a lesion treatment device and a vascular filter guide wire for directing the catheter to the lesion. The guide wire includes a collapsible filter for deployment downstream of the catheter to trap particulate matter dislodged from the lesion during the treatment.
  • [0013]
    In yet another form, the invention comprises a method of filtering particulate debris from a vasculature caused by treatment of a lesion with a catheter having a lesion treatment portion, the catheter being guided to the location of the lesion by a vascular filter guide wire having a core wire, a slidable shaft, and a collapsible filter mounted on the shaft and deployable upon relative displacement between the core wire and the shaft. The method includes the steps of first guiding the vascular filter guide wire through the vasculature along a predetermined path to a lesion such that the filter is disposed downstream of the lesion. The next step involves deploying the filter radially outwardly by shifting the shaft relative to the core wire. Then, the catheter is run over the guide wire along the predetermined path to position the lesion treatment portion of the catheter proximate the lesion. The method continues by treating the lesion according to a predetermined procedure then maintaining the filter in a deployed position until the risk of particulate matter is substantially eliminated. The catheter is then withdrawn from the vasculature and the filter retracted radially inwardly by shifting the shaft back to the original position. The method then concludes with the step of removing the guide wire from the vasculature.
  • [0014]
    One embodiment of the invention comprises a vascular filter for controllably expanding within a blood vessel to trap particulate matter loosened from treatment of a lesion. The filter is responsive to relatively shiftable control elements to expand and retract and includes a braid comprising a composite metallic/polymeric material. The material includes a plurality of metallic filaments mounted to the respective shiftable shaft and core wire to define a support structure and a polymeric mesh interwoven with the metallic filaments to define a strainer.
  • [0015]
    Another form of the invention comprises a method of fabricating a vascular filter. The method includes the steps of first selecting a mandrel having a plurality of consecutively connected forms and weaving a continuous layer of braid over the consecutively connected forms. The method proceeds by bonding the braid filaments at spaced apart sections between respective forms and separating the respective braided forms at the bonded sections. The forms are then removed from the layer of braid.
  • [0016]
    Other features and advantages of the present invention will be apparent from the following detailed description when read in conjunction with the accompanying drawings.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0017]
    [0017]FIG. 1 is an enlarged, partial sectional view of a catheter system of the present invention deployed within a blood vessel;
  • [0018]
    [0018]FIG. 2 is a partial longitudinal view of a guide wire in a retracted position according to a first embodiment of the present invention;
  • [0019]
    [0019]FIG. 3 is a partial longitudinal sectional view along line 3-3 of FIG. 2;
  • [0020]
    [0020]FIG. 4 is a partial longitudinal sectional view similar to FIG. 3 but in a deployed orientation;
  • [0021]
    [0021]FIG. 5 is an enlarged view of detail 5-5;
  • [0022]
    [0022]FIG. 6 is a longitudinal view of a filter construction according to an alternative embodiment of the present invention;
  • [0023]
    [0023]FIG. 7 is a longitudinal view of a filter construction according to yet another embodiment of the present invention;
  • [0024]
    [0024]FIG. 8 is a mandrel system for use in the method of the present invention;
  • [0025]
    [0025]FIG. 9 is a block diagram illustrating steps in preparing the mandrel of FIG. 8;
  • [0026]
    [0026]FIG. 10 is a block diagram illustrating steps in fabricating the filter of the present invention;
  • [0027]
    [0027]FIG. 11a-11 g are views of various stages of construction corresponding to the steps of FIG. 10;
  • [0028]
    [0028]FIG. 12 is a partial longitudinal sectional view of a guide wire in a retracted state according to a second embodiment of the present invention;
  • [0029]
    [0029]FIG. 13 is a partial view of the guide wire of FIG. 12 in an extended state;
  • [0030]
    [0030]FIG. 14 is an axial view along line 14-14 of FIG. 13;
  • [0031]
    [0031]FIG. 15 is an axial view similar to FIG. 14 and showing an alternative strut arrangement; and
  • [0032]
    [0032]FIG. 16 is an axial view similar to FIG. 14 and showing an alternative strut arrangement.
  • DETAILED DESCRIPTION OF THE INVENTION
  • [0033]
    With reference to FIG. 1, percutaneous angioplasty or stent placement techniques enable operators to minimize trauma often associated with more invasive surgical techniques.
  • [0034]
    This is possible through the use of a thin catheter 20 that advances through the vascular system to a predetermined blood vessel 22 having a lesion such as a stenosis 24 blocking the flow of blood therethrough. Typically, the catheter includes a lesion treatment device such as a balloon 26 or stent (not shown) for positioning coaxially within the lesion. Once positioned, the balloon or stent radially expands, as shown at 28, to exert a radially outwardly directed force against the material and initiate dilation thereof.
  • [0035]
    In order to reach the lesioned area, however, the catheter must be able to follow a trackable path defined by a catheter guide wire. In accordance with a first embodiment of the present invention, a catheter guide wire, generally designated 30, provides a trackable path for a catheter and includes a distally disposed collapsible filter 50 to trap particulate matter dislodged by the catheter 20 during treatment of the stenosis.
  • [0036]
    Referring now to FIGS. 2 through 5, the guide wire 30 includes a proximal section 32 comprising a solid core wire 34 having a wave-shaped proximal end 36 (FIG. 2). A tubular shaft 38 is coaxially disposed around the core wire and includes an outer diameter equal to the nominal size of the guide wire.
  • [0037]
    The inner diameter of the tube is sized to form a friction fit with the core wire proximal end when slid thereover during insertion and removal of the guide wire. The shaft functions to deploy and retract the filter device, and to guide and support the catheter 20, and to smoothly transmit rotation from the proximal section 32 to an intermediate section 40. Preferably, the shaft comprises a polyimide tube or hypotube. In some applications, where relatively long lengths are required, an extension (not shown) may be attached to the proximal section to increase the length up to three meters.
  • [0038]
    The intermediate section 40 extends axially from the proximal section 32 and generally comprises an extension of the shaft 38 to coaxially surround the core wire 34. The core wire is formed distally with a primary tapered portion 42 defining an annular shoulder 44 for mounting a coiled spring 46.
  • [0039]
    With further reference to FIGS. 2 through 5, the filter 50 comprises a braided basket 52 having respective inner and outer braid layers 54 and 56 (FIG. 5) that, in one embodiment, serve as supports for a fine filter mesh 58. The supports expand the basket radially outwardly with the filter axial ends compressed inwardly, and radially retract the basket with the ends tensioned outwardly. The fine mesh 58 (FIG. 5) is interposed between the inner and outer supports along a distal-half portion 60 of the basket to prevent particulate matter from flowing through the blood vessel downstream of the treated stenosis. It is contemplated that the size of the pores of mesh 58 may be in the range of 40 to 500 microns. The meshed distal-half of the filter forms a collection cavity 62 for the material such that when retracted, the material is prevented from escaping the filter.
  • [0040]
    The proximal end of the filter basket is bonded (e.g. adhesively or by soldering) to the shaft 38 which may be inserted between braid layers 54 and 56.
  • [0041]
    The distal extremity 57 of basket abuts a flexible coil spring 66 that coaxially surrounds the tip of the core wire 34. The guide wire distal tip is tapered and terminates in a hemispherically shaped tip 72 which is also bonded (e.g. by soldering) to the tip. The guide wire distal tip may be preformed into a “J” configuration (not shown) to aid in advancing the guide wire 30 through the vasculature.
  • [0042]
    With particular reference to FIG. 6, the preferred embodiment of filter 50 according to the present invention includes a braid comprising a composite metallic/polymeric material, eliminating the necessity of a separate mesh layer. In such an embodiment, a plurality of metallic filaments 82 provide structural support to the assembly for deploying and collapsing the filter. Polymeric filaments 84 are located on the distal half of the braid only, to provide a filtration cone 86. The dual materials, braided simultaneously, provide a pic density which will result in filtration spacing of approximately 40 to 500 microns for filtration, at a metal to polymeric ratio of approximately 1:4.
  • [0043]
    In yet another embodiment of a filter according to the present invention, generally designated 90 and illustrated in FIG. 7, the filtering medium is wrapped in a cylinder 92 with a closed distal end 94 and a flared proximal end 95. Flaring of the proximal end may be effected by applying heat and pressure to the material thereby increasing the surface area and causing the material to bow radially outwardly. The cylinder is formed with longitudinal pleats (not shown) that are more flexible and collapsible than a straight cone configuration.
  • [0044]
    Referring now to FIGS. 8 and 9, fabrication of the filter 50 may be performed in accordance with a series of process steps as described below. Initially, a mandrel 96 (FIG. 8) with a series of molded forms 97 and 98 is prepared by selecting a mandrel of appropriate length, at step 100 (FIG. 9), and providing a plurality of crimps 101 (FIG. 8) on the mandrel at intervals of approximately two to three inches, at step 102. The process proceeds by placing molds over the crimps, at step 104, filling the molds with a dissolvable compound, at step 106, curing the compound, at step 108, and removing the molds, at step 110. Suitable materials for molding include water soluble plastics such as polyethylene oxide, chemical soluble plastics such as styrene or PVC, and other water soluble materials such as sugar cubes, or gypsum based compounds. Molded forms may be continuously fabricated along the length of the crimped mandrel sections to maximize production efficiency. Another suitable method envisioned is to individually form the molds and bond to straight mandrels.
  • [0045]
    Referring now to FIGS. 10 and 11a-g, following preparation of the mandrel 96, the mandrel itself is selected for the method of fabricating the filters, at step 112. The method progresses by selecting a braider, at step 114, and braiding the inner layer 54 (FIG. 11a), at step 116, over the mandrel form system. Because of the convenient serially connected system of forms on the mandrel, the braider progressively weaves a continuous layer of braid over the consecutively connected forms. After the braid is applied, the mandrel is removed from the braider, at step 118, so that a curable epoxy may be applied to define an adhesive joint 119 (FIG. 11b) along spaced apart sections of the braid between forms. This step bonds braid filaments together, at step 120, so that subsequent separation of the forms minimizes deformation of the braid.
  • [0046]
    A center section 121 (FIG. 11c) of each braid is then cut, at step 122, and a prefabricated filter 123 (FIG. 11d) installed over one side of each form, at step 124. The individual segments are then reconnected, at step 126, by splicing a section of heat shrink tubing 127 (FIG. 11e) over each severed joint.
  • [0047]
    After the segments are re-connected, the mandrel assembly is then re-installed into the braider for braiding of the outer basket 56 (FIG. 11f), at step 128. Following braiding, the mandrel is removed from the braider, at step 130, with the braid filaments bonded together to form a joint 131 (FIG. 11g), at step 132. The mandrel is then cut at approximately one millimeter on the outside end of the adhesive, at step 134. At this point, the molded form may be dissolved by an appropriate solvent, at step 136, and the mandrel removed, at step 138. Lastly, a polyimide sleeve is bonded, at step 140, to the end opposite the filter.
  • [0048]
    The alternative filter embodiment 80 may be fabricated similar to the procedure above with only minor variations. Conveniently, because of the composite nature and relatively high pic density of the metallic/polymeric braid, only one braiding step is required. After the final braid, the polymeric strands at the proximal end are mechanically or thermally cut away, and the filaments fused at the large diameter of the formed cone to form the collection cavity and to allow for greater blood flow.
  • [0049]
    In operation, the guide wire 30 may be advanced through a vascular system in any conventional manner to establish a path for the catheter to track over. Generally, as shown in FIG. 1, the guide wire is inserted through the lesion and disposed downstream of the lesion 24 a variably selected distance. The distance selected by the operator may be conveniently adjusted merely by further advancing or slightly withdrawing the guide wire. This provides the highly desirable capability of enabling the operator to independently adjust the selected distance to preclude the possibility of embolic material progressing through a branch path between the lesion and the filter. The catheter 20 is then inserted along the guide wire to access the treatment area. Typically, image scanning techniques aid in the exact positioning of the catheter relative to the lesion such that the lesion treatment device will have maximum effectiveness.
  • [0050]
    The filter may then be deployed by actuating an actuating mechanism (not shown) coupled to the core wire 34 for axially moving the shaft 38 relative to the core wire. As the shaft advances axially along the core wire in the distal direction, the filter basket 52, having its distal end 57 attached to the fixed core wire and its proximal end connected to the shaft, compresses axially and expands radially outwardly against the inner walls of the blood vessel. In its expanded state, the filter 50 collects any plaque that may have loosened and become dislodged from the treated area.
  • [0051]
    Once the treatment concludes, and the catheter is withdrawn from the body, the filter is retracted radially inwardly by shifting the shaft back to its original position. As the filter retracts, the collection cavity 62 traps any material strained against the filter layer. The guide wire itself is then carefully withdrawn from the vasculature.
  • [0052]
    Referring now to FIGS. 12 through 16, a temporary filter guide wire according to a further embodiment of the present invention is shown, and generally designated 200. The guide wire generally includes a proximal end 202 having an actuating mechanism 208, an intermediate portion 220 including a housed collapsible filter element 222, and a flexible distal end 240.
  • [0053]
    With particular reference to FIG. 12, the proximal end 202 includes a solid stainless steel core wire 204 having a diameter, for example, of approximately 0.0075 inches and slidably confined coaxially by an elongated shaft 206. The shaft may include, for example, an inner diameter of approximately 0.010 inches and an outer diameter of approximately 0.014 inches. The proximal tip of the core wire nests within the handle mechanism 208 that includes a rotatable handle element 209 having a formed central blind bore 210 and a threaded hollow shank 212. A fixed threaded base 214 having a throughbore 216 receives the proximal portion of the shaft 206 and rotatably engages the handle element to define the actuating mechanism.
  • [0054]
    Referring now to FIGS. 12 and 13, the core wire 204 and the shaft 206 extend longitudinally to define the intermediate portion 220 of the guide wire. The filter element 222 is mounted to the intermediate portion and includes an intermediate quad filar spring 224 of approximately 0.002 inch diameter wire that extends approximately three to seven centimeters from the end of the shaft, depending on the application. The respective ends of four wires comprising the quad spring are unwound, straightened, and outwardly biased approximately forty-five degrees from the spring axis at spaced apart radial locations to define a plurality of umbrella shaped filter struts 226. These struts form the support structure for the filter. As shown in FIGS. 14, 15, and 16, the strut spacing may conveniently take on a variety of configurations depending on the particular application desired. Lashed to the struts is a fine wire mesh 228 of approximately 0.001 inches think within 40 to 500 micron pores for straining particulate matter from the bloodstream.
  • [0055]
    Further referring to FIG. 12, the radial exterior of the distal portion of the core wire 204 carries a bonded housing or pod 230 having an axially open mouth 232 slightly larger in diameter than the diameter of the filter in a closed configuration. The mouth opens into a cavity sufficiently sized to fully enclose the filter during insertion or withdrawal of the guide wire. The pod would also have a rounded inward edge at its proximal opening so as to envelop the filter when retracted and prevent unintentional engagement of a stent or catheter upon withdrawal. The pod may be fabricated out of a spring material wound in the opposing direction as the spiral struts to improve the sliding of the two surfaces. Other options include a lubricious plastic such as polyethylene.
  • [0056]
    The distal end 240 of the guide wire 200 comprises an extension of the core wire 204 from a bonded distal joint and surrounded by a distal spring member 242 that bonds to and projects outwardly from the distal side of the filter housing 230. The distal end terminates in a tip 244 that typically takes on a pre-formed “J” shape (not shown) for steering purposes through the vascular system.
  • [0057]
    Operation of the second embodiment proceeds in much the same way as that of the first embodiment, with the guide wire 200 first directed through the vasculature, followed by tracking with a treating catheter. Like the first embodiment, the guide wire 200 is advantageously adjustable in the blood vessel independent of the catheter, allowing a variable selected distance between the location of the stenosis and the filter.
  • [0058]
    However, the way in which the filter 222 expands and retracts differs somewhat from the previously described embodiment.
  • [0059]
    With the handle mechanism 208 in a normally open configuration, the operator turns the rotatable element 209 to incrementally drive the core wire 104 axially with respect to the shaft 206. The relative axial displacement of the core wire causes the filter housing 230 to become disengaged from the filter struts 226. Because of the spring biased nature of the filter struts 226, as the filter exits the housing, the struts expand radially outwardly against the blood vessel wall such that the wire mesh spans the vessel diameter. In its extended state, the filter allows bloodflow to continue through the vessel while dislodged material becomes entrapped in the wire mesh for collection in the cavity.
  • [0060]
    Once the lesion treatment procedure is complete, and the necessity for filtering has completely diminished, the handle mechanism is actuated to pull the core wire back to its original position. This activity causes the housing mouth to re-engage the filter struts and urge the struts radially inwardly as the housing encloses the filter. With the filter fully retracted, the streamlined guide wire may be easily and safely withdrawn from the body.
  • [0061]
    Those skilled in the art will appreciate the many benefits and advantages afforded the present invention. Of relative importance is the feature that avoids any additional control wires, beyond the guide wire itself, in order to expand and retract the filter. Not only does this minimize the number of components necessary to practice the invention, but the angioplasty procedure itself is made safer for the patient.
  • [0062]
    Additionally, the present invention provides the capability of adjusting the distance between the filter and the catheter lesion treatment device in vivo, eliminating the need to withdraw the guide wire or catheter for distance adjustment should the relative spacing be inadequate.
  • [0063]
    The filter itself, in one embodiment, provides substantial manufacturability benefits by requiring only a single braiding step. Consequently, braiding additional filter layers adding to the device's complexity are eliminated. By minimizing the process steps required to fabricate the filter, costs involved in manufacture are greatly reduced.
  • [0064]
    Moreover, the method of fabricating filters according a to the present invention offers added efficiencies in manufacture due to the production line processing scheme.
  • [0065]
    Employing such a scheme serves to dramatically improve the throughput rate of filters to minimize overall costs.
  • [0066]
    While the invention has been particularly shown and described with reference to the preferred embodiments thereof, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the invention.
  • [0067]
    For example, the invention may be used in any intravascular treatment utilizing a guide wire where the possibility of loosening emboli may occur. Although the description herein illustrates angioplasty and stent placement procedures as significant applications, it should be understood that the present invention is in no way limited only to those environments.
Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US3540431 *Apr 4, 1968Nov 17, 1970Kazi Mobin UddinCollapsible filter for fluid flowing in closed passageway
US4577631 *Nov 16, 1984Mar 25, 1986Kreamer Jeffry WAneurysm repair apparatus and method
US4619246 *May 20, 1985Oct 28, 1986William Cook, Europe A/SCollapsible filter basket
US4643184 *Apr 17, 1984Feb 17, 1987Mobin Uddin KaziEmbolus trap
US4650466 *Nov 1, 1985Mar 17, 1987Angiobrade PartnersAngioplasty device
US4723549 *Sep 18, 1986Feb 9, 1988Wholey Mark HMethod and apparatus for dilating blood vessels
US4727873 *Nov 26, 1986Mar 1, 1988Mobin Uddin KaziEmbolus trap
US4790812 *Nov 15, 1985Dec 13, 1988Hawkins Jr Irvin FApparatus and method for removing a target object from a body passsageway
US4790813 *May 30, 1986Dec 13, 1988Intravascular Surgical Instruments, Inc.Method and apparatus for surgically removing remote deposits
US4794928 *Jun 10, 1987Jan 3, 1989Kletschka Harold DAngioplasty device and method of using the same
US4817600 *May 22, 1987Apr 4, 1989Medi-Tech, Inc.Implantable filter
US4842579 *Jul 29, 1988Jun 27, 1989Surgical Systems & Instruments, Inc.Atherectomy device
US4873978 *Dec 4, 1987Oct 17, 1989Robert GinsburgDevice and method for emboli retrieval
US4921478 *Feb 23, 1988May 1, 1990C. R. Bard, Inc.Cerebral balloon angioplasty system
US4926858 *Aug 7, 1989May 22, 1990Devices For Vascular Intervention, Inc.Atherectomy device for severe occlusions
US4943297 *Jan 6, 1989Jul 24, 1990Saveliev Viktor SDevice for preparation of intravenous filter for implantation
US4950238 *Jul 20, 1989Aug 21, 1990Clarence E. SikesHydro-rotary vascular catheter
US4969891 *Apr 13, 1990Nov 13, 1990Gewertz Bruce LRemovable vascular filter
US4979951 *Jan 18, 1989Dec 25, 1990Simpson John BAtherectomy device and method
US5092839 *Sep 29, 1989Mar 3, 1992Kipperman Robert MCoronary thrombectomy
US5108419 *Aug 16, 1990Apr 28, 1992Evi CorporationEndovascular filter and method for use thereof
US5112347 *May 14, 1991May 12, 1992Taheri Syde AEmbolectomy catheter, and method of operating same
US5147379 *Nov 26, 1990Sep 15, 1992Louisiana State University And Agricultural And Mechanical CollegeInsertion instrument for vena cava filter
US5152777 *Jan 25, 1989Oct 6, 1992Uresil CorporationDevice and method for providing protection from emboli and preventing occulsion of blood vessels
US5154724 *Jan 24, 1992Oct 13, 1992Andrews Winston AAtherectomy catheter
US5160342 *Dec 30, 1991Nov 3, 1992Evi Corp.Endovascular filter and method for use thereof
US5324304 *Jun 18, 1992Jun 28, 1994William Cook Europe A/SIntroduction catheter set for a collapsible self-expandable implant
US5329942 *Mar 20, 1992Jul 19, 1994Cook, IncorporatedMethod for filtering blood in a blood vessel of a patient
US5354310 *Mar 22, 1993Oct 11, 1994Cordis CorporationExpandable temporary graft
US5397331 *Nov 25, 1992Mar 14, 1995Cook IncorporatedSupporting device and apparatus for inserting the device
US5549626 *Dec 23, 1994Aug 27, 1996New York Society For The Ruptured And Crippled Maintaining The Hospital For Special SurgeryVena caval filter
US5662671 *Jul 17, 1996Sep 2, 1997Embol-X, Inc.Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries
US5695518 *Apr 7, 1995Dec 9, 1997Laerum; FrodeFiltering device for preventing embolism and/or distension of blood vessel walls
US5695519 *Nov 30, 1995Dec 9, 1997American Biomed, Inc.Percutaneous filter for carotid angioplasty
US5720764 *Jun 10, 1995Feb 24, 1998Naderlinger; EduardVena cava thrombus filter
US5769816 *Apr 30, 1996Jun 23, 1998Embol-X, Inc.Cannula with associated filter
US5779716 *Oct 6, 1995Jul 14, 1998Metamorphic Surgical Devices, Inc.Device for removing solid objects from body canals, cavities and organs
US5795322 *Apr 9, 1996Aug 18, 1998Cordis CorporationCatheter with filter and thrombus-discharge device
US5810874 *Jan 22, 1997Sep 22, 1998Cordis CorporationTemporary filter catheter
US5814064 *Mar 6, 1997Sep 29, 1998Scimed Life Systems, Inc.Distal protection device
US5827324 *Mar 6, 1997Oct 27, 1998Scimed Life Systems, Inc.Distal protection device
US5876367 *Dec 5, 1996Mar 2, 1999Embol-X, Inc.Cerebral protection during carotid endarterectomy and downstream vascular protection during other surgeries
US5910154 *Feb 12, 1998Jun 8, 1999Embol-X, Inc.Percutaneous catheter and guidewire having filter and medical device deployment
US5928260 *Jul 10, 1997Jul 27, 1999Scimed Life Systems, Inc.Removable occlusion system for aneurysm neck
US5941896 *Dec 16, 1997Aug 24, 1999Montefiore Hospital And Medical CenterFilter and method for trapping emboli during endovascular procedures
US5972019 *Jun 5, 1997Oct 26, 1999Target Therapeutics, Inc.Mechanical clot treatment device
US6059814 *Aug 29, 1997May 9, 2000Medtronic Ave., Inc.Filter for filtering fluid in a bodily passageway
US6258115 *Apr 21, 1998Jul 10, 2001Artemis Medical, Inc.Bifurcated stent and distal protection system
US6695519 *May 7, 2002Feb 24, 2004Meadwestvaco CorporationDouble portfolio
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US6969395Aug 7, 2002Nov 29, 2005Boston Scientific Scimed, Inc.Electroactive polymer actuated medical devices
US7011654Feb 12, 2001Mar 14, 2006Artemis Medical, Inc.Dilating and support apparatus with disease inhibitors and methods for use
US7147649Jul 30, 2001Dec 12, 2006Duke UniversityTemporary vascular filters
US7220271Jan 30, 2003May 22, 2007Ev3 Inc.Embolic filters having multiple layers and controlled pore size
US7232432Jan 14, 2005Jun 19, 2007Artemis Medical, Inc.Particle-removing medical device and method
US7323001Jan 30, 2003Jan 29, 2008Ev3 Inc.Embolic filters with controlled pore size
US7413622Sep 27, 2004Aug 19, 2008Ev3 Inc.Method of training nitinol wire
US7524319Jun 14, 2004Apr 28, 2009Artemis Medical, Inc.Particle-removing medical device and method
US7662165May 21, 2003Feb 16, 2010Salviac LimitedEmbolic protection device
US7766934Jul 11, 2006Aug 3, 2010Cook IncorporatedEmbolic protection device with an integral basket and bag
US7771452Aug 10, 2010Cook IncorporatedEmbolic protection device with a filter bag that disengages from a basket
US7780697Jan 31, 2007Aug 24, 2010Salviac LimitedEmbolic protection system
US7785342May 21, 2003Aug 31, 2010Salviac LimitedEmbolic protection device
US7799051Jun 27, 2005Sep 21, 2010Salviac LimitedSupport frame for an embolic protection device
US7833242Nov 16, 2010Salviac LimitedEmbolic protection device
US7837701Nov 23, 2010Salviac LimitedEmbolic protection device
US7842063Nov 30, 2010Salviac LimitedEmbolic protection device
US7842066Nov 30, 2010Salviac LimitedEmbolic protection system
US7846175Dec 7, 2010Medrad, Inc.Guidewire and collapsable filter system
US7846176Jan 31, 2007Dec 7, 2010Salviac LimitedEmbolic protection system
US7850708Dec 14, 2010Cook IncorporatedEmbolic protection device having a reticulated body with staggered struts
US7867247Feb 26, 2010Jan 11, 2011Cook IncorporatedMethods for embolic protection during treatment of a stenotic lesion in a body vessel
US7901426Mar 8, 2011Salviac LimitedEmbolic protection device
US7901427Mar 8, 2011Salviac LimitedFilter element with retractable guidewire tip
US7927349Jun 13, 2007Apr 19, 2011Salviac LimitedSupport frame for an embolic protection device
US7955351Jun 7, 2011Tyco Healthcare Group LpRapid exchange catheters and embolic protection devices
US7972352Nov 4, 2004Jul 5, 2011Salviac LimitedEmbolic protection system
US8002790Jun 27, 2005Aug 23, 2011Salviac LimitedSupport frame for an embolic protection device
US8021377Oct 21, 2005Sep 20, 2011Boston Scientific Scimed, Inc.Electroactive polymer actuated medical devices
US8052640Feb 1, 2007Nov 8, 2011The Cleveland Clinic FoundationMethod and apparatus for increasing blood flow through an obstructed blood vessel
US8052716Nov 8, 2011Salviac LimitedEmbolic protection system
US8057504Nov 15, 2011Salviac LimitedEmbolic protection device
US8109962Jun 19, 2006Feb 7, 2012Cook Medical Technologies LlcRetrievable device having a reticulation portion with staggered struts
US8114115Jun 13, 2007Feb 14, 2012Salviac LimitedSupport frame for an embolic protection device
US8123776Jun 1, 2005Feb 28, 2012Salviac LimitedEmbolic protection system
US8137376Apr 26, 2007Mar 20, 2012Tyco Healthcare Group LpEmbolic filters having multiple layers and controlled pore size
US8152831Nov 16, 2006Apr 10, 2012Cook Medical Technologies LlcFoam embolic protection device
US8182508May 22, 2012Cook Medical Technologies LlcEmbolic protection device
US8187298May 29, 2012Cook Medical Technologies LlcEmbolic protection device having inflatable frame
US8216269Nov 2, 2006Jul 10, 2012Cook Medical Technologies LlcEmbolic protection device having reduced profile
US8216270Jul 10, 2012Salviac LimitedEmbolic protection device
US8221446Jul 17, 2012Cook Medical TechnologiesEmbolic protection device
US8221448Jun 13, 2007Jul 17, 2012Salviac LimitedEmbolic protection device
US8226678Jun 13, 2007Jul 24, 2012Salviac LimitedEmbolic protection device
US8241319Aug 20, 2007Aug 14, 2012Salviac LimitedEmbolic protection system
US8252017Aug 28, 2012Cook Medical Technologies LlcInvertible filter for embolic protection
US8252018Sep 14, 2007Aug 28, 2012Cook Medical Technologies LlcHelical embolic protection device
US8317748Jul 15, 2011Nov 27, 2012The Cleveland Clinic FoundationMethod and apparatus for increasing blood flow through an obstructed blood vessel
US8328842Feb 7, 2011Dec 11, 2012Salviac LimitedFilter element with retractable guidewire tip
US8366663Oct 25, 2011Feb 5, 2013The Cleveland Clinic FoundationMethod and apparatus for increasing blood flow through an obstructed blood vessel
US8377092Feb 19, 2013Cook Medical Technologies LlcEmbolic protection device
US8388644Mar 5, 2013Cook Medical Technologies LlcEmbolic protection device and method of use
US8409242Apr 2, 2013Covidien LpEmbolic filters with controlled pore size
US8419748Apr 16, 2013Cook Medical Technologies LlcHelical thrombus removal device
US8430901Jun 13, 2007Apr 30, 2013Salviac LimitedEmbolic protection device
US8452068Nov 2, 2011May 28, 2013Covidien LpHybrid registration method
US8467589Jun 18, 2013Covidien LpHybrid registration method
US8473032Jun 2, 2009Jun 25, 2013Superdimension, Ltd.Feature-based registration method
US8565858Jun 23, 2009Oct 22, 2013Covidien LpMethods and systems for performing medical procedures with reference to determining estimated dispositions for actual dispositions of projective images to transform projective images into an image volume
US8603131Dec 13, 2006Dec 10, 2013Salviac LimitedEmbolic protection device
US8632562Oct 2, 2006Jan 21, 2014Cook Medical Technologies LlcEmbolic protection device
US8647359 *Jan 10, 2002Feb 11, 2014Boston Scientific Scimed, Inc.Distal protection filter
US8657849Feb 5, 2013Feb 25, 2014Cook Medical Technologies LlcEmbolic protection device and method of use
US8696622Nov 8, 2012Apr 15, 2014DePuy Synthes Products, LLCMethod and apparatus for increasing blood flow through an obstructed blood vessel
US8702652Nov 8, 2012Apr 22, 2014DePuy Synthes Products, LLCMethod and apparatus for increasing blood flow through an obstructed blood vessel
US8784467May 14, 2010Jul 22, 2014Lemaitre Vascular, Inc.Non-occlusive dilation devices
US8795315Oct 6, 2005Aug 5, 2014Cook Medical Technologies LlcEmboli capturing device having a coil and method for capturing emboli
US8845677Dec 23, 2011Sep 30, 2014Cook Medical Technologies LlcRetrievable device having a reticulation portion with staggered struts
US8852226Jul 15, 2011Oct 7, 2014Salviac LimitedVascular device for use during an interventional procedure
US8945169Mar 14, 2006Feb 3, 2015Cook Medical Technologies LlcEmbolic protection device
US9011478Mar 14, 2006Apr 21, 2015Covidien LpEmbolic filters with a distal loop or no loop
US9117258May 20, 2013Aug 25, 2015Covidien LpFeature-based registration method
US9138307Sep 14, 2007Sep 22, 2015Cook Medical Technologies LlcExpandable device for treatment of a stricture in a body vessel
US9186487Dec 21, 2012Nov 17, 2015Genesis Technologies LlcMedical device and method
US9271803May 2, 2013Mar 1, 2016Covidien LpHybrid registration method
US9314259Oct 8, 2012Apr 19, 2016Crux Biomedical, Inc.Devices and methods for vessel occlusion
US9351748 *Mar 22, 2012May 31, 2016Crux Biomedical, Inc.Distal protection devices and methods of providing distal protection
US20010027307 *Feb 12, 2001Oct 4, 2001Dubrul William RichardDilating and support apparatus with disease inhibitors and methods for use
US20020161392 *Jan 17, 2002Oct 31, 2002Dubrul William R.Particle-removing medical device and method
US20020193686 *Jan 2, 2001Dec 19, 2002Pinhas GilboaMethods and systems for performing medical procedures with reference to projective image and with respect to pre-stored images
US20030009189 *Jan 30, 2002Jan 9, 2003Salviac LimitedEmbolic protection device
US20030032977 *Jul 3, 2002Feb 13, 2003Salviac LimitedFilter element with retractable guidewire tip
US20030130682 *Jan 10, 2002Jul 10, 2003Scimed Life Systems, Inc.Distal protection filter
US20030130684 *Dec 23, 2002Jul 10, 2003Eamon BradySupport frame for an embolic protection device
US20030144687 *Dec 23, 2002Jul 31, 2003Salviac LimitedSupport frame for an embolic protection device
US20030199913 *Jun 9, 2003Oct 23, 2003Artemis Medical, Inc.Occlusion, anchoring, tensioning and flow direction apparatus and methods for use
US20030208227 *Jul 30, 2001Nov 6, 2003John ThomasTemporary vascular filters and methods
US20040087982 *Aug 7, 2002May 6, 2004Eskuri Alan DavidElectroactive polymer actuated medical devices
US20040199202 *Dec 29, 2003Oct 7, 2004Genesis Technologies LlcBiological passageway occlusion removal
US20040236369 *Jun 14, 2004Nov 25, 2004Artemis Medical, Inc.Particle-removing medical device and method
US20040260333 *Apr 15, 2004Dec 23, 2004Dubrul William R.Medical device and method
US20050124931 *Jan 14, 2005Jun 9, 2005Artemis Medical, Inc.Particle-removing medical device and method
US20050251246 *Jun 2, 2005Nov 10, 2005Artemis Medical, Inc.Dilating and support apparatus with disease inhibitors and methods for use
US20060041264 *Oct 21, 2005Feb 23, 2006Eskuri Alan DElectroactive polymer actuated medical devices
US20060184194 *Feb 14, 2006Aug 17, 2006Cook IncorporatedEmbolic protection device
US20060259069 *Mar 27, 2006Nov 16, 2006Salviac LimitedEmbolic protection device
US20070135834 *Feb 8, 2007Jun 14, 2007Ev3 Inc.Embolic filters with controlled pore size
US20070173883 *Aug 23, 2006Jul 26, 2007Martin KeeganEmbolic protection system
US20070173884 *Dec 13, 2006Jul 26, 2007Salviac LimitedEmbolic protection device
US20070233179 *Jun 13, 2007Oct 4, 2007Abbott LaboratoriesSupport frame for an embolic protection device
US20070233180 *Jun 13, 2007Oct 4, 2007Abbott LaboratoriesSupport frame for an embolic protection device
US20080114439 *Oct 23, 2007May 15, 2008Venkatesh RamaiahNon-occluding dilation device
US20080234722 *Jun 13, 2007Sep 25, 2008Possis Medical, Inc.Inferior vena cava filter on guidewire
US20080275485 *Apr 3, 2006Nov 6, 2008Possis Medical, Inc.Guidewire with collapsible filter system and method of use
US20090264729 *Oct 22, 2009Pinhas GilboaMethods And Systems For Performing Medical Procedures With Reference To Projective Image And With Respect To Pre Stored Images
US20100036481 *Feb 11, 2010Artemis Medical, Inc.Cardiovascular Devices and Methods
US20110054516 *Mar 3, 2011Salviac LimitedEmbolic protection method
US20110082490 *May 14, 2010Apr 7, 2011Lemaitre Vascular, Inc.Non-Occlusive Dilation Devices
US20110230861 *Sep 22, 2011Tyco Healthcare Group LpRapid exchange catheters and embolic protection devices
US20120179196 *Jul 12, 2012Eric JohnsonDistal protection devices and methods of providing distal protection
US20140155929 *Feb 7, 2014Jun 5, 2014Emboline, Inc.Embolic protection device
US20140364897 *Jun 10, 2014Dec 11, 2014Subbarao V. MylaMethods And Devices For Embolic Protection
WO2004014238A2Aug 7, 2003Feb 19, 2004Scimed Life Systems, Inc.Electroactive polymer actuated medical devices
WO2004066826A3 *Jan 30, 2004Jul 28, 2005Ev3 IncEmbolic filters having multiple layers and controlled pore size
WO2004093966A1 *Apr 15, 2004Nov 4, 2004Genesis Technologies Llc.Medical device and method
Classifications
U.S. Classification606/200
International ClassificationA61F2/01
Cooperative ClassificationY10T29/49801, Y10T29/49604, A61F2002/018, A61F2230/0006, A61F2230/0021, A61F2230/005, A61F2230/0093, A61F2230/0086, A61F2230/0067, A61F2230/0097, A61F2/013, A61M2025/09183, A61F2002/011, A61M25/09, A61F2002/016, A61F2/01
European ClassificationA61F2/01, A61F2/01D