US20030187495A1 - Endoluminal devices, embolic filters, methods of manufacture and use - Google Patents
Endoluminal devices, embolic filters, methods of manufacture and use Download PDFInfo
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- US20030187495A1 US20030187495A1 US10/113,724 US11372402A US2003187495A1 US 20030187495 A1 US20030187495 A1 US 20030187495A1 US 11372402 A US11372402 A US 11372402A US 2003187495 A1 US2003187495 A1 US 2003187495A1
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- JAPMJSVZDUYFKL-UHFFFAOYSA-N C1C2C1CCC2 Chemical compound C1C2C1CCC2 JAPMJSVZDUYFKL-UHFFFAOYSA-N 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N C1CCCCC1 Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
- A61F2/0108—Both ends closed, i.e. legs gathered at both ends
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
- A61F2/013—Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
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- A—HUMAN NECESSITIES
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Vascular Medicine (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Surgical Instruments (AREA)
- Prostheses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
Description
- The present invention relates to seamless endoluminal devices including frame patterns for filters, their manufacture and use in the filtration and/or removal of embolic matter from fluids flowing in tubular body lumens including, but not limited to: blood flow in arteries and veins; airflow within the respiratory tract; and the flow of urine in the urinary tract. The seamless filter of the present invention may be self-expanding, is deployable via a guidewire-based system and has a low profile.
- Embolic protection is a concept of growing clinical importance directed at reducing the risk of embolic complications associated with interventional (i.e., transcatheter) and surgical procedures. In therapeutic vascular procedures, liberation of embolic debris (e.g., thrombus, clot, atheromatous plaque, etc.) can obstruct perfusion of the downstream vasculature, resulting in cellular ischemia and/or death. The therapeutic vascular procedures most commonly associated with adverse embolic complications include: carotid angioplasty with or without adjunctive stent placement and revascularization of degenerated saphenous vein grafts. Additionally, percutaneous transluminal coronary angioplasty (PTCA) with or without adjunctive stent placement, surgical coronary artery by-pass grafting, percutaneous renal artery revascularization, and endovascular aortic aneurysm repair have also been associated with complications attributable to atheromatous embolization. Intraoperative capture and removal of embolic debris, consequently, may improve patient outcomes by reducing the incidence of embolic complications.
- The treatment of stenoses of the carotid bifurcation provides a good example of the emerging role of adjuvant embolic protection. Cerebrovascular stroke is a principle source of disability among adults, and is typically associated with stenoses of the carotid bifurcation. The current incidence of cerebrovascular stroke in Europe and the United States is about 200 per 100,000 population per annum (Bamford,Oxfordshire community stroke project. Incidence of stroke in Oxfordshire. First year's experience of a community stroke register. BMJ 287: 713-717, 1983; Robins, The national survey of stroke: the National Institute of Neurological and Communicative Disorders and Stroke. Office of Biometry and Field Studies Report.
Chapter 4. Incidence. Stroke 12 (Suppl. 1): 1-57, 1981). Approximately half of the patients suffering ischemic stroke have carotid artery stenoses (Hankey, Investigation and imaging strategies in acute stroke and TIAs. Hospital Update 107-124, 1992). Controlled studies have shown that the surgical procedure carotid endarterectomy (CEA) can reduce the incidence of stroke in patients compared to medical therapy with minimal perioperative complications (<6% for symptomatic patients with stenoses >70% [NASCET, Beneficial effect of carotid endarterectomy in symptomatic patients with high grade stenoses. NEJM 325: 445-453, 1991] and <3% for asymptomatic patients with 60% stenoses [ACAS, Endarterectomy for asymptomatic carotid artery stenosis. JAMA 273: 1321-1461, 1995]). These results provide convincing evidence of the benefit of treating carotid stenoses. Surgery, however, does have several limitations, including: increased mortality in patients with significant coronary disease (18%), restriction to the cervical portion of the extra-cranial vasculature, a predeliction for cranial palsies (7.6%-27%), and restenosis (5%-19%; Yadav, Elective stenting of the extracranial carotid arteries. Circulation 95: 376381, 1997). - Carotid angioplasty and stenting have been advocated as potential alternatives to CEA. Percutaneous techniques have the potential to be less traumatic, less expensive, viable in the non-cervical extracranial vasculature, and amenable to patients whom might otherwise be inoperable (Yadav,Elective stenting of the extracranial carotid arteries. Circulation 95: 376-381, 1997). Despite the potential benefits of this approach, emboli liberated during trans-catheter carotid intervention can place the patient at risk of stroke. Emboli can be generated during initial accessing of the lesion, balloon pre-dilatation of the stenosis, and/or during stent deployment. Additionally, prolapse of atheromatous material through the interstices of the stent can embolize after the completion of the procedure.
- The fear of dislodging an embolus from an atherosclerotic plaque has tempered the application of angioplasty and endovascular stenting to the supraaortic arteries and, particularly, to the carotid bifurcation (Theron,New triple coaxial catheter system for carotid angioplasty with cerebral protection. AJNR 11: 869-874, 1990). This concern is warranted due to the significant morbidity and/or mortality that such an event might produce. While the incidence of stroke may be at an acceptable level for the highly skilled practitioner, it is likely to increase as the procedure is performed by less experienced clinicians.
- Embolic protection devices typically act as an intervening barrier between the source of the clot or plaque and the downstream vasculature. In order to address the issue of distal embolization, numerous apparatus have been developed and numerous methods of embolic protection have been used adjunctively with percutaneous interventional procedures. These techniques, although varied, have a number of desirable features including: intraluminal delivery, flexibility, trackability, small delivery profile to allow crossing of stenotic lesions, dimensional compatibility with conventional interventional implements, ability to minimize flow perturbations, thromboresistance, conformability of the barrier to the entire luminal cross-section (even if irregular), and a means of safely removing the embolic filter and trapped particulates.
- For example, occlusion balloon techniques have been taught by the prior art and involve devices in which blood flow to the vasculature distal to the lesion is blocked by the inflation of an occlusive balloon positioned downstream to the site of intervention. Following therapy, the intraluminal compartment between the lesion site and the occlusion balloon is aspirated to evacuate any thrombus or atheromatous debris that may have been liberated during the interventional procedure. These techniques are described in Theron,New triple coaxial catheter system for carotid angioplasty with cerebral protection. AJNR 11: 869-874, 1990, and Theron, Carotid artery stenosis: Treatment with protected balloon angioplasty and stent placement. Radiology 201: 627-636, 1996, and are commercially embodied in the PercuSurge Guardwire Plus™ Temporary Occlusion and Aspiration System (Medtronic AVE). The principle drawback of occlusion balloon techniques stem from the fact that during actuation distal blood flow is completely inhibited, which can result in ischemic pain, distal is stasis/thrombosis, and difficulties with fluoroscopic visualization due to contrast wash-out through the treated vascular segment.
- Another prior system combines a therapeutic catheter (e.g., angioplasty balloon) and integral distal embolic filter. By incorporating a porous filter or embolus barrier at the distal end of a catheter, such as an angioplasty balloon catheter, particulates dislodged during an interventional procedure can be trapped and removed by the same therapeutic device responsible for the embolization. One known device includes a collapsible filter device positioned distal to a dilating balloon on the end of the balloon catheter. The filter comprises a plurality of resilient ribs secured to the circumference of the catheter that extend axially toward the dilating balloon. Filter material is secured to and between the ribs. The filter deploys as a filter balloon is inflated to form a cup-shaped trap. The filter, however, does not necessarily seal around the interior vessel wall. Thus, particles can pass between the filter and the vessel wall. The device also presents a large profile during positioning and is difficult to construct.
- The prior art has also provided systems that combine a guidewire and an embolic filter. The filters are incorporated directly into the distal end of a guidewire system for intravascular blood filtration. Given the current trends in both surgical and interventional practice, these devices are potentially the most versatile in their potential applications. These systems are typified by a filter frame that is attached to a guidewire that mechanically supports a porous filter element. The filter frame may include radially oriented struts, one or more circular hoops, or a pre-shaped basket configuration that deploys in the vessel. The filter element typically includes a polymeric mesh net, which is attached in whole or in part to the filter frame and/or guidewire. In operation, blood flowing through the vessel is forced through the mesh filter element thereby capturing embolic material in the filter.
- Early devices of this type include a removable intravascular filter mounted on a hollow guidewire for entrapping and retaining emboli. The filter is deployable by manipulation of an actuating wire that extends from the filter into and through the hollow tube and out the proximal end. During positioning within a vessel, the filter material is not fully constrained so that, as the device is positioned through and past a clot, the filter material can potentially snag clot material creating freely floating emboli, prior to deployment.
- In another prior art system an emboli capture device is mounted on the distal end of a guidewire. The filter material is coupled to a distal portion of the guidewire and is expanded across the lumen of a vessel by a fluid activated expandable member in communication with a lumen running the length of the guidewire. During positioning, as the device is passed through and beyond the clot, filter material may interact with the clot to produce emboli. This device may also be difficult to manufacture.
- Another prior art device is adapted for deployment in a body vessel for collecting floating debris and emboli in a filter that includes a collapsible proximally tapered frame for operably supporting the filter between a collapsed insertion profile and an expanded deployment profile. The tapered collapsible frame includes a mouth that is sized to extend to the walls of the body vessel in the expanded deployed profile to seal the filter relative to the body vessel for collecting debris floating in the body vessel.
- A further example of an embolic filter system involves a filter material fixed to cables or spines of a central guidewire. A movable core or fibers inside the guidewire can be utilized to transition the cables or spines from approximately parallel to the guidewire to approximately perpendicular to the guidewire. The filter, however, may not seal around the interior vessel wall. Thus, particles can pass between the filter and the entire vessel wall. This umbrella-type device is shallow when deployed so that, as it is being closed for removal, particles have the potential to escape.
- Other disadvantages associated with the predicate devices are that the steerability of the guidewire may be altered as compared to the conventional guidewires due to the presence and size of the filter. The guidewire, for example, may bend, kink, and/or loop around in the vessel, making insertion of the filter through a complex vascular lesion difficult. Also, delivery of such devices in a low-profile pre-deployment configuration can be difficult. Further, some devices include complex and cumbersome actuation mechanisms. Also, retrieving such capture devices after they have captured emboli may be difficult. Further, when deployed in curved segments, the interaction of the guidewire and/or tether elements can deform the filter frame in such a way as to limit apposition to the host vessel wall, thereby allowing potential channels for passage of embolic debris. Also, the filter media of the prior art maintains a pore diameter of approximately 80 to 120 microns. It is desirable to minimize the pore size without adversely perturbing blood flow or being prone to clogging.
- Current filter designs suffer from numerous disadvantages due to their construction. A typical wire filter is formed by manipulating multiple wires together through welding or some other form of attachment. After the wire frame is constructed, it is formed into the desired shape and a filter element is affixed onto the wire cage. A typical wire frame constructed in this manner is subject to a limited range of manipulation after the wires are adhered, since the welds or attachment areas are at an increased risk of failure due to the physical constraints of the welds themselves. A wire pair is more inclined to fracture at the weakest point, typically, a wire frame, composed of numerous wire pairs, will separate at the weld before separating in the length of the wire. Additionally, the welding of metal involves the application of increased heat to join a wire pair and a risk exists of the mesh, formed by the pairs, dripping or otherwise malforming due to the proclivity of metal to run before cooling.
- A further disadvantage to a typical wire filter is that the filter element is difficult to apply to the frame since the filter is normally applied as a sock, tube, or other such shape. The typical wire frame is formed by welding and bending into the desired shape. The filter is then affixed onto the shaped wire frame by pulling the formed filter over the shaped wire frame. An additional problem evident in this construction is that the filter element could be abraded by a protrusion formed by a weld in a wire pair. Such an abrasion could form a weakness or a tear in the filter and undermine its desired functionality.
- Simple and safe blood filtering and guidewire systems that can be temporarily placed in the vasculature to prevent distal embolization during endovascular procedures, and that can be used to introduce and/or exchange various instruments to a region of interest without compromising the position of the filter or guidewire, are required. Existing guidewire-based embolic filtering devices are inadequate for these and other purposes. The present apparatus, in contrast, provides a novel means of providing these and other functions, and has the further benefit of being easier to manufacture than the devices of the prior art.
- The present invention relates to seamless implantable devices, filters, methods of manufacture, systems for deployment and methods of use.
- One aspect of the present invention is to provide a low profile filter formed from a single piece of material.
- Another aspect of the present invention is to provide a self-expanding filter that is seamless.
- A further aspect of the present invention is to provide an integral self-expanding filter frame that is seamless.
- A still further object of the present invention is to provide a seamless, low-profile filter that minimally perturbs flow.
- A further aspect of the present invention to provide a low profile, seamless filter that is readily connected to the guidewire of a endoluminal deployment system.
- A further aspect of the invention is to provide a filter apparatus, which maintains vessel wall apposition and a maximally open mouth when deployed in tortuous anatomy.
- A further aspect of the invention is to provide a filter frame, which can be rendered sufficiently radiopaque.
- A further aspect of the present invention is to provide filters which have increased capture efficiency and are capable of providing drug delivery.
- A further aspect according to the present invention includes providing a seamless frame having a proximal end, a longitudinal axis, a seamless support member circumscribing the axis and distally spaced from the proximal end, and at least one attachment strut, and optionally at least one filter strut seamlessly extending from the support member.
- Another aspect of the present invention is to provide a seamless frame having a proximal end, a longitudinal axis, a seamless support member circumscribing the axis and distally spaced from the proximal end, and at least one attachment strut, optionally at least one filter strut seamlessly extending from the support member, and at least one or more filter media layers.
- Another aspect of the present invention is to provide implantable devices that may be configured as detachable devices designed for permanent implantation and/or subsequent retrieval and are used for: temporary vascular occluders; exclusion of bleeding varices or aneurysmal vascular segments; a stent, or similar means of providing structural support to an endoluminal cavity; a thrombectomy/atherectomy instrument; an implantable prosthetic vascular conduit wherein the proximal filter frame functions as an anchoring stent, and the distal filter is configured into an open-ended, tubular configuration (similar to a windsock) allowing endoluminal lining of a vascular segment with a biocompatible liner.
- An aspect of the present invention is to provide seamless implantable devices formed from a single piece of material.
- Another aspect of the present invention is to provide seamless implantable devices that have regions of articulation and/or radiopaque markers.
- A further aspect of the present invention to provide seamless implantable devices that include radiopaque markers.
- A still further aspect of the present invention is to provide stents or similar means of providing structural support to an endoluminal cavity, and which may include regions of articulation and/or radiopaque markers.
- A further aspect of the present invention to provide a seamless stent, or similar means of providing structural support to an endoluminal cavity.
- A still further aspect of the present invention is to provide a delivery system for the inventive seamless devices, stents, occluders, filters and its use. These and other features and aspects of the invention will become more apparent in view of the following detailed description, non-limiting examples, appended claims and drawings.
- FIGS. 1A, 1B and1C illustrate the steps of constructing a first two-dimensional frame, whereas FIGS. 1D and 1E illustrate a resulting three-dimensional shape with a filter media attached thereto.
- FIGS. 2A, 2B and2C respectively illustrate an alternate configuration of a two-dimensional frame, a resulting three-dimensional shape after annealing and a depiction of the frame with a filter media attached.
- FIGS. 3A, 3B and3C respectively illustrate an alternate configuration of a two-dimensional frame, a resulting three-dimensional shape after annealing and a depiction of the frame with a filter media attached.
- FIGS. 4A, 4B and4C respectively illustrate an alternate configuration of a two-dimensional frame, a resulting three-dimensional shape after annealing and a depiction of the frame with a filter media attached.
- FIGS. 5A, 5B and5C respectively illustrate an alternate configuration of a two-dimensional frame, a resulting three-dimensional shape after annealing and a depiction of the frame with a filter media attached.
- FIGS. 6A, 6B and6C respectively illustrate an alternate configuration of a two-dimensional frame, a resulting three-dimensional shape after annealing and a depiction of the frame with a filter media attached.
- FIGS. 7A, 7B and7C respectively illustrate an alternate configuration of a two-dimensional frame, a resulting three-dimensional shape after annealing and a depiction of the frame with a filter media attached.
- FIG. 7D illustrates an annealed frame pattern having articulation segments in the attachment struts and FIG. 7E illustrates a frame pattern having longitudinally spaced support members interconnected by articulation segments.
- FIGS. 8A, 8B and8C respectively illustrate an alternate configuration of a two-dimensional frame, a resulting three-dimensional shape after annealing and a depiction of the frame with a filter media attached.
- FIGS. 9A, 9B and9C respectively illustrate an alternate configuration of a two-dimensional frame, a resulting three-dimensional shape after annealing and a depiction of the frame with a filter media attached.
- FIGS. 10A, 10B and10C respectively illustrate an alternate configuration of a two-dimensional frame, a resulting three-dimensional shape after annealing and a depiction of the frame with an integral filter media.
- FIGS. 11A, 11B and11C respectively illustrate an alternate configuration of a two-dimensional frame, a resulting three-dimensional shape after annealing and a depiction of the frame with a filter media attached.
- FIGS. 12A, 12B,12C, 12D and 12E respectively illustrate alternate apex and strut configurations adapted to accept and house radio-opaque markers.
- FIG. 13 illustrates a three-dimensional frame with an attached filter media positioned between a guidewire and an atraumatic tip.
- FIGS. 14A and 14B depict the filtering apparatus as deployed within a vessel having tortuous anatomy.
- FIG. 15 illustrates an alternate system for assembling an alternate embolic filter configuration.
- FIG. 16 illustrates a system for assembling a filter-in-filter device.
- FIG. 17 illustrates the filter-in-filter assembled using the system of FIG. 16.
- FIGS. 18A, 18B and18C respectively illustrate a tooling device, a two-dimensional frame being formed into a three-dimensional configuration, and the tooling device supporting the three-dimensional frame for annealing.
- FIGS. 19A, 19B and19C respectively illustrate the steps for converting a conical filter into “sombrero” shaped filter configuration.
- FIG. 19D illustrates a three-dimensional frame supporting a “sombrero” shaped filter media.
- FIGS. 19E and 19F depict an alternative filter sack configuration in which the sack resembles an asymmetric cone.
- FIGS. 20A, 20B and20C respectively illustrate a filter-in-filter configuration with a pharmacological agent loaded in the space between the filter media, an alternate filter configuration with the filter media pre-loaded with the pharmacological agent, and the elution of the pharmacological agent in a lumen/vessel of a host.
- FIGS. 21A and 21B respectively illustrate deployment of an occluder device in a lumen/vessel of a host and the detachment of the occluder.
- FIGS. 22A and 22B respectively illustrate the deployment of an obstruction remover and collection of removed lesion debris in a lumen/vessel of a host.
- FIGS. 23A, 23B and23C illustrate the use of an anchoring device for treatment of a lesion in tortuous vessels associated with renal anatomy.
- FIGS. 24A, 24B,24C, 24D and 24E respectively illustrate a two dimensional frame, a three-dimensional resulting shape, an endovascular device formed from the three-dimensional frame and an open-ended windsock, the occlusion of a sacular aneurysm in a host lumen/vessel with the endovascular device and optional use of a stent lining the device.
- FIG. 25A illustrates a delivery catheter having a guidewire lumen and guidewire supported filter.
- FIGS. 25B, 25C,25D and 25E respectively illustrate views of alternate distal catheter delivery tips.
- FIGS. 25F, 25G and25H respectively illustrate three-dimensional top views of catheter tube having a channel indented in its surface adjacent its distal end, a sleeve covering the indented channel and a guidewire located in the sleeve covered-indented channel.
- FIGS. 26A, 26B,26C 26D and 26E respectively illustrate steps followed in treating a lesion in a host lumen/vessel.
- FIGS. 27A, 27B and27C respectively illustrate a view of the distal tip a delivery catheter with an alternate auxiliary lumen configuration, a three-dimensional top view of the auxiliary lumen configuration and an auxiliary lumen mounted guidewire.
- FIG. 28 illustrates a configuration of the present invention deployed as an implantable vena cava filter.
- FIGS. 29A and 29B respectively illustrate an alternate two-dimensional planar configuration of the present invention, and a three-quarter isometric view of this configuration formed into a three-dimensional shape designed for use as an implantable stent.
- FIG. 30 is a flat pattern view of a filter frame and integral tether elements as would be cut from a tube.
- FIG. 31 is a flat pattern view of a filter frame and integral tether elements after being formed and annealed at a functional size.
- FIGS. 32A, 32B,32C, 32D and 32E respectively show variations in the tether geometry, designed to allow the tethers to articulate with respect to one another and to the filter frame itself.
- As used herein the following terms are defined as followed:
- The term “proximal” is defined as the location closest to the catheter hub and “distal” is the location most distant from the catheter hub. With respect to the inventive three-dimensional uni-body frame, the term “proximal” is the frame end attached to the guidewire or the frame side through which debris enters to be collected by an associated filter.
- The term “uni-body” refers to a frame pattern formed from a single piece of material and therefore considered “seamless.”
- Terms such as unitary, integral, one-piece are synonymous with “uni-body” and also refer to a frame pattern that is formed from a single or common piece of material.
- Filament, wire or ribbon are alternate terms used to describe the portions/sections of pattern material that remain after etching a planar precursor frame material and form the attachment struts, the support struts, the filter/filter support struts that extend in the longitudinal, circumferential, or any other direction necessary to define a frame pattern.
- FIGS.1A-1D schematically show the four method steps that are followed to manufacture a uni-body, self-expanding filter device in accordance with the present invention. FIG. 1A shows a
flat sheet material 110, preferably a shape memory alloy material, e.g., a NiTi alloy, Nitinol, or any other suitable bioacceptable material, such as a metal, e.g., stainless steel, or bioacceptable polymer. Theflat sheet material 110 is used to form the “uni-body”frame pattern 115 of FIG. 1C, or other frame patterns described hereinafter. - A desired pattern is formed on
sheet material 110, as in the case of FIG. 1B, which shows a radially symmetric filter frame pattern having six “pie” shapedwedges 120. Thewedges 120 are removed by etching in a chemical photo-etching process, or any other suitable technique, to form a frame defined by filament sized material. The frame pattern can also be obtained by using a laser or any other cutting procedure or process capable of precisely etching, stamping, or otherwise cutting theflat sheet 110 into the preferred shape. - Radial sides125, 130 and
arcuate side 135 circumscribe thewedges 120.Slits 145 are formed andcenter section 150 is removed by any suitable cutting technique. After theslits 145 are formed, andwedges 120 andcenter section 150 removed, flashing 140 is removed (such as by trimming with fine scissors or diagonal cutters), leaving the desired skeletal two-dimensional filter frame/pattern 115, shown in FIG. 1C. -
Skeletal frame 115 includes attachment struts 155 withproximal ends 165 that are to be fixed or attached to proximal connectingmember 170 of FIG. 1 D, adapted to cooperate with a guidewire (not shown). Attachment struts 155 extend seamlessly from support struts 156 because they are formed from the same precursor material. Support struts 156 are seamlessly connected to or seamlessly interconnected with one another. - Seamlessly interconnected support struts156 define a boundary, perimeter or cell having the configuration of a six-pointed “star.” When
frame 115 is converted into a three-dimensional configuration, the seamlessly associated/interconnected struts 156 typically form a “closed”support member 156A that circumscribes the longitudinal axis of the three-dimensional frame, thereby providing a radial or transverse dimension to the three-dimensional frame. The boundary, perimeter, cell orsupport member 156A can be any geometric configuration so long as it provides a radial dimension (transverse to the longitudinal axis) for the frame. The support member circumscribes the longitudinal axis of the frame and may also be described as being ring-shaped. In addition to providing the frame with a radial dimension, as shown in FIG. 1D, thesupport member 156A is typically the location for attaching the proximalopen end 161 of thefilter 160. Thus the support member also functions to maintain the proximal end offilter media 160 in the open operative configuration.Filter media 160 may be formed from any suitable material, and also includes a closeddistal end 162. - The planar, two-dimensional frame pattern of FIG. 1C is then annealed, normally by thermal annealing, into a three-dimensional configuration. The three-dimensional annealed
frame configuration 175, may be further processed, as described hereinafter, to include a filter media resulting infilter 100 which includes theframe 175 and filtermedia 160, as in FIGS. 1D and 1E. For ease of consistency and brevity throughout the remainder of the application and without relinquishing equivalents thereof, Nitinol is used as the filter frame material in each and every embodiment shown and described hereinafter. However, as discussed above, other suitable materials, such as, titanium nickel alloys, shape memory materials, biocompatible metals, e.g., stainless steel, or plastic may be used for the uni-body filter frame. - FIGS.2A-2C through 11A-11C depict alternate filter frame patterns that can be formed following the procedures described with reference to FIGS. 1A-1E. As a result, the various struts are seamlessly interconnected since they are formed from the same precursor material.
- FIG. 2A illustrates a plan view of an
alternate frame pattern 215 having hoop shapedstruts 256 connected to attachment struts 255. FIG. 2B illustrates the threedimensional filter frame 275 after annealing with proximal ends of the attachment struts 255 fixed to the proximal connectingmember 270 and struts 256 seamlessly connected to one another and forming aclosed support member 256A. As with FIG. 1C, struts 255 seamlessly extend fromsupport member 256A. FIG. 2C illustrates afilter 200 attached to aguidewire 280. Thefilter 200 includes the three-dimensional frame 275 with afilter media 260 having a “butterfly” configuration. The configuration offilter media 260 can also be described as substantially parabolic. - FIG. 3A illustrates an alternate two-dimensional (plan view)
frame pattern 315 having attachment struts 355, attachment strut proximal ends 365, filter struts 385 which may also supportoptional filter media 360 of FIG. 3D.Filter pattern 315 also includes support struts 356. Support struts 356 and filter struts 385, which are seamlessly associated with one another, cooperate to definecell 357, which is configured in the shape of a diamond.Struts Struts 356 define a boundary around sixcells 357 and form aclosed support member 356A for maintaining the three-dimensional filter of FIG. 3C in an open, operative configuration. FIG. 3B illustrates three-dimensional frame 375 that is obtained after the two dimensional filter frame pattern is annealed, with the proximal ends 365 of the attachment struts 355 fixed to proximal connectingmember 370. In the embodiment of FIG. 3B, the filter struts 385 allow the device to be used as a filter, without the filter media shown in FIG. 3C. While the filter pattern of FIG. 3B shows six filter struts 385, any number of filter struts or support struts can be used, including, but not limited to 4, 5, 7, 8, 9, 10, 11, 12, etc. In addition, although FIG. 3A depicts thefilter frame 315 with diamond shaped cells/openings 357,cells 357 can be of any geometrical shape or size, so long as the openings are of sufficient size to permit blood flow and/or filtering. FIG. 3C illustrates the annealed filter frame pattern of FIG. 3B withfilter media 360 attached to aguidewire 380. - FIG. 4A illustrates a two-dimensional alternate
seamless frame pattern 415 having attachment struts 455, support struts 456, and filter/filter media support struts 485. The pattern is seamless because it is formed from the same precursor material. FIGS. 4B and 4C illustrate three-dimensional views offilter frame pattern 475 after annealing, with the proximal ends of the attachment struts 455 fixed to the proximal connectingmember 470, support struts 456 formingsupport member 456A, and filter media support struts 485 extending in a distal direction. FIG. 4C illustrates the annealedfilter frame pattern 475 of FIG. 4B withfilter media 460 attached to aguidewire 480. - FIG. 5A illustrates the two-dimensional alternate
seamless filter pattern 515 having attachment struts 555, support struts 556, filtermedia support members 590, and filter support struts 585. The pattern is seamless because it is formed from the same precursor material. FIGS. 5B and 5C illustrate three-dimensional views of thefilter frame pattern 515 of FIG. 5A after annealing,frame 575, with proximal ends of the attachment struts 555 fixed to the connectingmember 570, support struts 556 of FIG. 5A form closedsupport member 556A, and filter media support struts 585 extend distally away from theproximal connector 570. FIG. 5C illustrates the annealedfilter frame pattern 575 of FIG. 5B withfilter media 560 attached to aguidewire 580. - FIG. 6A illustrates the two-dimensional alternate
seamless filter pattern 615 having attachment struts 655, support struts 656 and filter support struts 685. The pattern is seamless because it is formed from the same precursor material. FIGS. 6B and 6C illustrate three-dimensional views offilter frame pattern 615 of FIG. 6A after annealing, with the proximal ends of the attachment struts 655 fixed to the connectingmember 670, support struts 656 of FIG. 6A formingsupport member 656A and filter media support struts 685. FIG. 6C illustrates the annealedfilter frame pattern 675 of FIG. 6B withfilter media 660 attached to aguidewire 680. - FIG. 7A illustrates a two-dimensional view of a seamless
alternate filter pattern 715 having attachment struts 755 and support member struts 756. The pattern is seamless because it is formed from the same precursor material, for supporting the open end offilter media 760 of FIG. 7C. FIGS. 7B and 7C illustrate side views of the three-dimensional filter frame 775, after annealing, with the proximal ends of the attachment struts 755 fixed to the connectingmember 770 and support struts 756 of FIG. 7A formingsupport member 756A. FIG. 7C illustrates the annealed filter frame pattern of FIG. 7B withfilter media 760 attached to aguidewire 780. FIG. 7D illustrates the annealed frame pattern havingarticulation segments 790 in the attachment struts 755. FIG. 7E illustrates an alternate design, wherein there are two longitudinally spacedsupport members 756A seamlessly interconnected to one another byarticulation segments 790, described in greater detail hereinafter. - FIG. 8A illustrates a two-dimensional view of an alternate spirally configured
filter pattern 815. FIGS. 8B and 8C illustrate three-dimensional views of thefilter frame pattern 815 of FIG. 8A after annealing,frame 875, with a proximal end of theframe 875 fixed to the connectingmember 870. FIG. 8C illustrates the annealed filter frame pattern of FIG. 8B withfilter media 860 attached to aguidewire 880. In the filter frame illustrated in FIG. 8B, one of the turns of the spirally shaped frame, which is not “closed,” forms the support member that provides radial dimension to the frame. - FIG. 9A illustrates a two-dimensional view of an alternate
seamless filter pattern 915 having attachment struts 955 and filter media support struts 985. The pattern is seamless because it is formed from the same precursor material. FIGS. 9B and 9C illustrate three-dimensional views of the filter frame pattern after annealing,frame 975, with the proximal ends of the attachment struts 955 fixed to the proximal connectingmember 970. In this embodiment the filter media support struts 985 closest to the proximal connector also function as the closed support member described herein to provide the transverse dimension of the frame and support the proximal end of thefilter 960. FIG. 9C illustrates the annealedfilter frame pattern 975 of FIG. 9B and filtermedia 960 attached to aguidewire 980. - FIG. 10A illustrates a two-dimensional view of an alternate
seamless filter pattern 1015 having attachment struts 1055 and a central portion of the planarNitinol precursor material 1010 rendered porous 1090. FIGS. 10B and 10C illustrate three-dimensional views of thefilter frame pattern 1015 of FIG. 10A after annealing,frame 1075, with the proximal ends of the attachment struts 1055 fixed to the connectingmember 1070, and theporous precursor material 1090 havingpleats 1095. FIG. 10C illustrates the annealedfilter frame pattern 1075 of FIG. 10B attached to aguidewire 1080. A separate filter media is not necessary in the embodiment illustrated in FIGS. 10A-11C because theporous precursor portion 1090 serves as the filter media. - FIG. 11A illustrates a two-dimensional view of an alternate
seamless filter pattern 1115 having attachment andfilter strut 1156 which will also function as theclosed support member 1156A shown in FIG. 11B. FIGS. 11B and 11C illustrate three-dimensional views of thefilter frame pattern 1115 of FIG. 11A after annealing,frame 1175, with the proximal end of theclosed support member 1156A fixed to the connectingmember 1170. FIG. 11C illustrates the annealedfilter frame pattern 1175 of FIG. 11B withfilter media 1160 attached to aguidewire 1180. - Although the above embodiments show a
single support member - FIGS. 12A, 12B,12C, 12D and 12E illustrate alternate configurations of stent strut, and apex designs which allow for, accept and house ancillary components. FIG. 12A depicts a
housing 1210, which could be machined, stamped, lasered or etched into the stent frame.Housing 1210 is then filled with amaterial 1250 such as gold or platinum-iridium (to provide enhanced radio-opacity) or with a therapeutic agent such as a drug (to provide a prescribed biological response). FIG. 12B depictshousing 1210 located along the side of a strut. FIG. 12C depictsmultiple housings 1210 along a strut. FIG. 12D depictsmultiple housings 1210 located within the strut periphery. FIG. 12E depicts an alternate shape (arrowhead) housing 1210 (to be used as a radiopaque marker housing) located within the strut periphery. It should be noted that multiple shapes and sizes of housings could be configured. The radiopaque markers could be located in any strut or support member of the frame of the filter or the stent. Advantages of the application of radio-opaque markers in the fashions shown are: 1) stent cross section thickness is not increased (lending to reduction in introductory device profiles), 2) allows for precise and uniform spacing of markers, and 3) allows for a multitude of shapes (dots, arrows and other characters such as letters or words) to be easily incorporated into the frame. The housings may also provide a cavity in which to insert and/or attach onboard electronics or sensors. - FIG. 13 illustrates an embolic
filter assembly system 1300 that includes three functionally distinct regions.Section 1300A includes a support wire that terminates at its distal end in connectingmember 1370. The support wire may be theguidewire 1380 used to deliver a therapeutic device, e.g., a deployment catheter or angioplasty balloon.Section 1300B is any one of the embolic filter devices described in FIGS. 1A-1E through 11A-11C described herein, or another other device described hereinafter.Section 1300C may include anatraumatic tip 1396 or other suitable tip known to those skilled in the art having a proximal end fixed/attached/cooperating with distal connecting member. - FIG. 14A depicts the
filter apparatus 1400 as deployed in avessel 1420 with tortuous anatomy. As shown, such a condition results in a non-linear apparatus deployment configuration. In order forfilter frame 1410 to maintain sufficient vessel wall apposition (which eliminates peri-device channel formations), thetether elements 1430 must be capable of deforming and/or articulating. - FIG. 14B depicts the
filter apparatus 1400 as deployed at a different site within thesame vessel 1420 anatomy of FIG. 14A, once again demonstrating the flexibility required of the deflecting and articulatingtether elements 1430. It is clear in this depiction that theguidewire 1440 does not necessarily follow the host vessel centerline. This phenomenon, coupled with anatomical variances and the requirement of complete vessel wall apposition of thefilter frame 1410 makes the inclusion of articulating tether elements 1430 a benefit and necessity for safe and confident embolic protection of downstream vasculature. - FIG. 15 illustrates an arrangement to attach a filter media to any of the annealed filter frames described herein. The
frame 1515, is sandwiched betweenfilter media portions cushion elements top plate 1500A andheated base plate 1500B. Thus, resulting three-dimensional lamination of FIG. 15 has a cross-sectional view that is substantially conical. Application of heat and pressure, viaheated platens filter media frame 1515. The filter frame configuration via the lamination procedure depicted in FIG. 15 results in a filter assembly configuration resembling a “butterfly net.” - FIG. 16 schematically shows an alternate procedure for attaching filter media to an annealed filter frame. In FIG. 16, an annealed
filter frame 1615 is sandwiched between adjacent laminae of inner filter media 1 660A andouter filter media 1660B. Heat and pressure are applied via upper and lower punch and dieplatens filter media frame 1615. During the heating and pressure lamination process, a vacuum may be applied in thelower platen 1600B thereby bonding the filter media and skeletal filter frame together. The filter media shown in FIG. 16 is normally interposed only within the immediate vicinity of thefilter frame 1615. Additionally, the application of the vacuum can be used to optimize the filter frame geometry. The method shown in FIG. 16 can produce a filter frame configuration that resembles a butterfly net, such as the one shown in the device of FIGS. 7A-7C. This method can also be used to produce a frame-supported “filter-in-filter,” which is shown in further detail in FIG. 17, described below. - FIG. 17 shows an alternate embodiment of the present invention incorporating a two stage “filter-in-filter” design. The filter-in-filter design will provide improved filtration efficiencies, such as allowing each filter lamina to have a different porosity by using an
inner filter media 1760A and anouter filter media 1760B. Alternatively, eitherfilter media outer filter media - FIGS. 18A, 18B, and18C schematically illustrate an annealing method in which a planar, two-dimensional filter frame is converted into a three-dimensional configuration with the use of an appropriate fixturing/tooling device, e.g., a mandrel.
Mandrel 1800A, shown in FIG. 18A, is used to form thefilter frame 1815 of FIG. 18B into the desired shape. After cutting a flat metal sheet into the desired two dimensional configuration, such as that described above, the proximal ends 1865 of attachments struts 1855, i.e., the endpoints of the two-dimensional filter frame 1815, are collected at a point along the axis of radial symmetry as shown in FIG. 18B. As depicted in FIG. 18C, thefilter frame 1815 is placed onto the fixturing device, which, in this case, is themandrel 1800A of FIG. 18A to impart a defined, three-dimensional configuration, and theframe 1815 of FIG. 18B is annealed to preserve the desired configuration. After annealing, the three-dimensional filter frame 1875 can be elastically deformed into its original two-dimensional shape where a filter media can be applied according to any of the methods described and illustrated herein. - Following the attachment of the filter media, the three-dimensional filter configuration is readily obtained.
- FIGS. 19A, 19B,19C and 19D illustrate an alternate filter configuration using a “sombrero” shaped
filter media 1960B with a supporting frame. To form the sombrero frame and filter shown in FIG. 19D, aconical filter 1960, as shown in FIG. 19A, has its closeddistal end 1962 inverted toward the openproximal end 1961 of theconical filter 1960, to form a convex, hat-like base as shown in FIG. 19B. This inversion shortens the filter length, but retains the original area of thefilter element 1960. Next, the convexity is increased until the apex 1963 extends beyond theopen end 1961, as shown in FIG. 19C. Thefilter 1960 thus has been shortened further, but the effective filter area still remains identical to the original conical filter area. Thesombrero filter 1960B is attached toframe 1975, FIG. 19D. The frame includes attachment struts that are fixed to a connectingmember 1970, which in turn is cooperatively associated with aguidewire 1955. Compared to conventional conical filter frame designs, the sombrero filter frame allows more surface area per unit length, or, alternatively, reduces filter length without compromising filter surface area and deflection of the trapped debris away from the vessel centerline. The desired sombrero filter frame configuration will also increase the reliable removal of entrapped debris. - FIGS. 19E and 19F depict an alternate filter sack configuration, also designed to collect and hold embolic debris away from the vessel centerline. In this case, an asymmetric cone shaped filter media sack1990 is produced and attached to the
filter frame 1960. Collected emboli will tend to collect at the tip of thesack 1990 and are t held offset in the vessel, thus allowing relatively unperturbed flow at the vessel centerline. - As shown in FIGS. 20A, 20B and20C, a filter in accordance with the present invention can be used to deliver a pharmaceutical substance, anti-thrombotic agent, drug, etc., into the blood flow in a host lumen/vessel by deploying the filter in a lumen/vessel of interest. In FIG. 20A, a filter device such as that described in FIG. 17 above, can be loaded with a pharmacological agent in one or more different areas before delivery into the host. Thus, the drug can be loaded between layers of the filter media. The
drug 2098 may be retained within the zone/space/area between theinner filter media 2060A andouter filter media 2060B ready to be delivered to the host. - Instead of using the filter-in-filter design of FIG. 17, any of the other filter configurations described herein can be used by imbibing the drug into the filter media itself. As shown in FIG. 20B, the
drug 2098 can be imbibed into themedia 2060 itself. - FIG. 20C illustrates drug administration in the host by deploying the drug delivering system of FIGS. 20A or20B in a host lumen/vessel so that the blood flows through the filter media to elute the pharmacological agent, e.g., drugs. This method of localized drug delivery is effective for eluting a pharmacological agent contained either between adjacent layers of filter media or imbibed directly into the filter media. Fluid flow through the filter device of FIGS. 20A or 20B, or any other filter configuration described herein containing pharmacological agents provides a mechanism of mass transfer to downstream perfusion beds. The pharmacological agent could be pre-loaded into the filter or injected post deployment perhaps through an extension of the support/guidewire.
- As shown in FIGS. 21A and 21B, occluding
device 2175 can be formed as a detachable endoluminal filter frame that can be implanted in the host. Theoccluding device 2175 thus implanted can either be permanently implanted or retrieved at a later point in time, such as is required in vena cava filtering applications. As shown in FIG. 21A, blood flow through the host can be obstructed by the implantation of thefilter frame apparatus 2100. Thefilter frame apparatus 2100, used as an indwelling or implantable occlusion device is shown in FIG. 21A. As shown in FIG. 21B, a guidewire orsupport wire 2180 includes adistal end 2181 that may be detached fromproximal connector 2170 that is connected to theoccluding device 2175 orfilter frame apparatus 2100. Thesupport wire 2180 is used to position or removeoccluding device 2175 orfilter frame apparatus 2100 from a lumen in a host. Theguidewire tip 2181 may be of any design for detachment from or reattachment toproximal connector 2170. Thus, theguidewire 2180 can have any capture capability, including screw threads, magnetic, ball-and-socket, male-female attachment, bayonet, or any type of coupling that will allow theguidewire 2180 to detach or reattach to theproximal connector 2170 for placement or movement therein. - FIGS. 22A and 22B illustrate the use of a filter (similar to the
filters 100 or 700, respectively shown in FIGS. 1D or 7C) to remove flow obstructions or to function as a thrombectomy device to remove intraluminal thrombus, for example. FIG. 22A shows an obstruction at the lumen wall in a blood vessel of the host. Though commonly the lesion will have formed in a restrictive manner, the lesion is shown in a cross-sectional area with an upper and a lower component, that has narrowed the effective diameter of the lumen.Filter 2200 includes sharpenedsupport members 2285 to enable the filter to be used as a type of scraper. Theframe 2275 shown herein includes afilter media 2260 as a “catch bag.” In FIG. 22B, thefilter 2200 is pulled with sharpenedmembers 2285, effectively shearing the obstruction/lesion from the vessel wall of the host. As the lesion is sheared from the wall, sheared lesion parts are collected in the catch bag orfilter media 2260. In this manner, the present filter frame can be used to remove lesions and collect the debris dislodged into the blood stream, to lessen the possibility of clotting downstream of the host vessel. This approach can likewise be used to capture and remove foreign objects from bodily passageways. - FIGS. 23A, 23B and23C respectively illustrate the use of the inventive filter as an anchoring guidewire to facilitate the retention of a guidewire position in tortuous vessels of the renal circulatory system, and in particular for branch lumens offset at angles of approximately 90°. Using the inventive filter frame as an anchor avoids or minimizes damage to the host vessel, and specifically avoids or minimizes damage to the endothelium of the host lumen/vessel. FIG. 23A shows a
lesion 2300A in a branch lumen/vessel 2300B associated with the renal anatomy of a host. In the non-limiting embodiment of FIGS. 23A-23C, thebranch lumen 2300B includes an approximate 90° turn toward the existing anatomy shown. As illustrated in FIG. 23B afilter frame 2375 is positioned and anchored in a renalcirculatory vessel 2300B to fix the position of thesupport wire 2380. A slight pressure is imposed on thesupport wire 2380 and the approximate 90° turn is extended to more than 90° without dislodging or altering the position of the guidewire in relation to the host anatomy as shown in FIG. 23B. - As shown in FIG. 23C, a
therapeutic catheter 2300C can be inserted over thesupport wire 2380 of the filter frame to perform the intervention. As a result, therapy devices can more easily negotiate a greater than 900 bend as shown in FIGS. 23B and 23C. Such therapy devices include, but are not limited to balloons, stents, etc. A further useful aspect of this embodiment is that, during its use, a long “exchange length” guidewire is unnecessary. Since this device is capable of maintaining it's positioning after deployment, the necessity of “rapid exchange” or “monorail” catheters are obviated. - FIGS. 24A, 24B,24C, 24D and 24E show a further embodiment of the present filter frame assembly, which is intended to function as an
implantable endoprosthesis 2476. As shown in FIGS. 24A and 24B, the initialseamless filter frame 2475 is formed from a loop-type frame 2415 from the same precursor material. In FIG. 24C, the proximal end of an open-ended “windsock” shapedgraft component 2477 is attached to the loop of thefilter frame 2475 to form anendoprosthesis 2476. In FIG. 24D, the loop-type frame 2475 with the attached open-ended windsock is deployed proximal to an aneurysmal defect, and the windsock shapedgraft component 2477 extends downstream of the frame, effectively excluding theaneurysm 2400A. Thus, frame and the opened ended sock function as an implantable prosthetic vascular conduit where thefilter frame 2475 functions as an anchoring stent, and the open-ended sock functions as a biocompatible liner. This device, shown in FIG. 24E, may then be optionally lined with astent 2480. This embodiment finds use as a stent and graft combination where the stent element would be deployed proximal to the intended therapy site and the graft element would be configured to be deployed by blood pressure. - FIGS.25A-25H illustrate an exemplary delivery system for deploying the
present filter frame 2575 orfilter 2500 of the present invention. FIG. 25A illustrates aframe 2575 or frame-filter 2500, such asframe 175 or frame-filter 100 of FIGS. 1D or 1E,frame 375 or frame-filter 300 of FIGS. 3B and 3C, or any of the other frame or frame—filter assembly herein described, attached to a support orguidewire 2580 and positioned within atubular delivery sheath 2500A of a delivery catheter. FIGS. 25B-25D illustrates front views taken from sectional plane A-A of FIG. 25A, but without theframe 2575 or frame-filter 2500. The section A-A1 (FIG. 25B) illustrates a dual lumen extrusion catheter sheath. Section A-A2 (FIG. 25C) illustrates a single lumen extrusion having an additional covering formed from a shrink tube. Section A-A3 (FIG. 25D) illustrates a second lumen adhered to the inner diameter of thetubular delivery sheath 2500A of FIG. 25A. - FIG. 25E-25H illustrate the perspective detail of
external guidewire 2580 loading of a catheter lumen. FIG. 25E is a front view of the FIG. 25G. FIG. 25F illustrates the catheter having a longitudinally extending indented channel, which, as seen in FIG. 25G is circumscribed by atubular section 2500C. Theguidewire 2580 is inserted into thelongitudinally extending channel 2500B between the external wall of the catheter and thetubular section 2500C. In use, a filter frame or filter-frame construct is pre-loaded into the distal end of the sheath adjacent to an exterior wire guide channel. The exterior wire guide is adapted to receive a guidewire in a rapid exchange configuration, however, unlike the prior art, the filter frame andguidewire 2580 are completely segregated and no aperture exists. - FIGS. 26A, 26B,26C, 26D and 26E illustrate a method of using a
filter frame assembly 2600 in accordance with the present invention. In FIG. 26A, a lumen/vessel 2600A of the host has alesion 2600B. Aguidewire 2680 is deployed into the lumen/vessel 2600A past thetarget lesion 2600B. Thereafter,guidewire 2680 is back-loaded into thedelivery system 2600C, such as the one described in FIGS. 25B-25D, 25F-25G, or FIG. 27B. Then thedelivery sheath 2600C is advanced across thetarget lesion 2600B. Thedelivery sheath 2600C is withdrawn, thereby allowing a self-expandingfilter 2600 to deploy. The self-expandingfilter 2600 is normally designed to deploy spontaneously after thedelivery sheath 2600C has been withdrawn in this manner. Thus, as shown in FIG. 26C, thefilter 2600 is deployed downstream of thelesion 2600B. Atherapeutic catheter 2600D, such as an angioplasty balloon, is routed over thesupport wire 2680 in FIG. 26D to treattarget lesion 2600B. As also shown in FIG. 26D, when the therapy is performed, thefilter 2600 functions to capture any emboli dislodged or removed by thetherapeutic catheter 2600D. Thereafter, as illustrated in FIG. 26E, thefilter 2600 is removed via insertion of atubular capturing catheter 2600E over the support wire and retraction of thefilter 2600 into thecapture catheter 2600E is performed. This retraction can be performed by pulling thefilter 2600 partially back into thecapture catheter lumen 2600E, effectively trapping theemboli 2600F. In this manner, the lesion is dissipated through a therapeutic catheter without the result of any of the dislodged emboli or debris dislodging into the host. - FIGS. 27A, 27B and27C illustrate a
lumen 2710 having an auxiliary, internally positionedchannel 2720 for receiving aguidewire 2730. FIG. 27A illustrates the tip of the sheath having an internally located, peripherally positionedauxiliary channel 2720 formed by “pinching” the end of the tube wall as shown in FIG. 27B. FIG. 27C shows theguidewire 2730 inserted through into the slit opening in the side of the catheter and exiting the tip. - FIG. 28 illustrates the use of the
inventive filter 2800, as a vena cava filter. Since the inventive filters described herein may be readily detachable, thefilter 2800 can be readily detached from a deployment guidewire. - FIG. 29A illustrates a planar two-dimensional seamless pattern, formed from metallic material, or any other suitable biocompatible material. FIG. 29B illustrates a three-dimensional stent member formed from the planar two-dimensional pattern of FIG. 29A, for use as an intraluminal stent. When extremely thin wall sections are required, such as in coronary stents, it is appropriate to fabricate the device from a planar sheet of material.
- Planar material can be manufactured thinner than tubing due to the extra requirements of concentricity placed upon tubing stock. It should be noted that although only one design has been depicted, a wide variety of patterns and cell geometries may be produced from planar material. The various cell geometries are defined by the interconnected struts of the stent. In FIGS. 29A and 29B four
interconnected struts 2910 define the foursided cell 2920. This planar material may be metallic or polymeric or a combination thereof, and in any case, may also be porous. Once the flat pattern is fabricated, it is formed into a 3-D shape (in the depicted instance, an open mesh tube). The formed stent may be either plastically deformable (and thus made from a malleable starting material) or may be self-expanding, in which case a super-elastic, pseudo-elastic or shape memory material may be used. Subsequent processing such as thermal treatment, diametric reduction, de-burring and polishing may be incurred, depending upon the specific stent design. It should be understood that multiple 3-D stent “units” could be manufactured in such a way and attached together to form a much longer device. - FIG. 30 depicts a view of a flat pattern of
filter frame 3010A andintegral tether element 3010B geometry as it would be cut from a tube. This tube may be made of a shape memory alloy such as Nitinol. Cutting could be accomplished by a variety of methods including machining, laser cutting, stamping or etching. - FIG. 31 depicts the flat pattern geometry of FIG. 30 subsequent to forming and annealing at a larger, functional size. Upon annealing, the
filter frame 3010A resiliently maintains this larger diametrical profile and the at least onetether element 3010B extends seamlessly from it. - FIGS.32A-32E depict alternate articulation segments formed as an integral part of the tether element thereby forming different tether element geometries, which allow articulation of the
tether elements 3010B in relation to thefilter frame 3010A. FIG. 32A depicts thetether element 3010B with an area of reduced strut width e.g. reduced cross-sectional area, to allow increased flexibility. FIG. 32B depictstether element 3010B with several individual areas of reduced strut width to allow increased flexibility. FIG. 32C depictstether element 3010B with a reduced width and formed “hinging” area to increase flexibility. FIG. 32D depictstether element 3010B with a reduced width and several formed “hinging” areas to increase flexibility. FIG. 32E depictstether element 3010B divided in two for a portion of its length. This division effectively increases the tether element flexibility so as to allow articulation. The articulation segment of the tether element, therefore, is configured to enhance the flexibility of the filter apparatus (and thus, conformance to the host vessel wall) as well as to minimize inadvertent trauma translated to the host vessel wall by movement or manipulation of the guidewire. - An articulation segment of the tether elements or struts is a desirable feature in that it allows adequate vessel wall apposition of the filter frame when the filter device is deployed in a curved segment of anatomy. In a curved segment, the tether element articulates and deflects to adjust for a non-linear deployment situation (See FIG. 14). Thus, the filter frame itself can maintain an uncompromised and fully deployed condition. Likewise, because of its ability to attenuate longitudinal translation, the articulation segment provides a means of mitigating trauma of the host vessel wall due to guidewire manipulation. It should also be noted that the required deflection and articulation of the tether elements could be bought about by metallurgical means rather than, or in combination with, geometrical means. For instance, the
tether 3010B and frame 3010A elements of FIGS. 32A-E, although seamless and integral, may be exposed to different thermal processing parameters (for example: through the use of fixturing to provide differential heat sink qualities), thus rendering thetether 3010B ductile and pliable while theframe 3010A maintains the stiffness required for adequate vessel wall apposition. - The articulation segments, though described with respect to the various frame patterns can be incorporated into any of the endovascular devices described herein. An articulation segment is a localized region that provides enhanced longitudinal flexibility. A localized region may have a cross-sectional area that is the same as the remaining part a strut, but differs in geometry. Alternatively, the localized region could have the same geometry but a different cross-sectional area, or both the cross-sectional area and geometry of the localized region differ from the remaining part of the strut. An endovascular stent can have articulation segments in any of the interconnected struts of FIGS. 29A and 29B.
- A radially-symmetric geometrical pattern comprising interconnected struts forming closed polygonal shaped cells was chemically etched from a sheet of Nitinol (NiTi) to produce a skeletal filter frame. The etching, preferably photoetching of Nitinol (Kemac Technologies, Irwindale, Calif.) is continued to achieve a desirable material thickness, to optimize the moment of inertia of the struts and to polish the surface finish.
- This filter frame is then subjected to a thermal treatment to set the phase transition temperature of the NiTi to approximately 37° C. by heating the filter frame to a temperature of about 450° C. for about 10 minutes in an air convection oven (Carbolite Corporation, Sheffield, England) followed by a rapid quench in ambient temperature water.
- The NiTi filter frame was then laminated between two (2) layers of an adhesive-coated porous polymer. The layers were positioned with the adhesive sides facing toward each other, and facing toward the NiTi. The adhesive was used to adhere the layers of film together as well as to the NiTi wire framework. A sacrificial porous polymer cushion material was used on each side of the device during this lamination procedure to provide compliance of the surface during compression. This compliance allows the earlier mentioned porous polymer membrane to conform to the wire shape. The composite sub-assembly which included cushion, porous polymer/adhesive laminate, NiTi, adhesive/porous polymer laminate, and cushion layers was then compressed in a SST fixture and heat treated at 320° C. for 45 minutes in an air convection oven (Grieve Oven, The Grieve Corporation, Round Lake, Ill.).
- Once the ‘sandwiched’ device was removed from the heat source and allowed to cool, the sacrificial cushion material was peeled away from each side of the device and the NiTi wires were disengaged from the fixture. A circular shape of approximately 0.625″ in diameter was trimmed into the porous polymer using a 20-watt carbon dioxide laser. The remainder of porous polymer was trimmed from the wire frame by hand and discarded-.
- Following the laser trimming operation (which can also be used to create the necessary pores in the filter media), the radially-oriented arms (struts) of the device were folded up and back on themselves to achieve a hollow, three dimensional, semi-conical shape. To maintain the device in this configuration, the NiTi struts were inserted into a SST tube. This tube measured approximately 0.05″ in length×0.035″ outer diameter×0.025″ inner diameter. This tube and indwelling NiTi wires were then crimped to a 0.014″ diameter guidewire to provide a guidewire based endoluminal embolic protection device. The device resembled a three dimensional “whisk” shape with a pleated porous polymer filter element attached to it.
- The resulting pleats are designed to increase filter media surface area over the generally conical shapes found in the prior art. This increase in surface area also allows for a shorter filter length which enhances deliverability of the device by a) decreasing friction in the delivery catheter and b) improving device overall flexibility.
- A 1.3 mm Nitinol tube with a wall thickness of approx 0.1 mm (obtained from Nitinol Devices and Components, Fremenot, Calif.) was laser cut (Laserage Technologies Inc, Waukegan, Ill.) to a single, undulating 6 apex ring geometry with integral tethers. This frame was then lightly grit blasted at 40 psi with 20 micron silicon carbide media in a grit blasting machine made by Comco Inc, Burbank, Calif. The ring with integral tethers was then gently pushed up a tapered mandrel until it achieved a functional size of approx. 6 mm. The ring, tethers and mandrel were then subjected to a thermal treatment to set the phase transition temperature of the NiTi to approximately 37° C. in an air convection oven (Carbolite Corporation, Sheffield, England) One skilled in the art will realize that variances in the geometry, metallurgy, thickness and heat treating of the filter frame can all be varied to create alternate embodiments with varying desirable properties. The ring and tethers (now at functional size) were then lightly coated with an fluorinated ethylene propylene (FEP) powder (FEP 5101 , available from Dupont Corp, Wilmington, Del.) by first stirring the powder in a kitchen blender (Hamilton Beach Blendmaster, Wal-Mart) after the power was mixed into a “cloud”, the frame was hung into the blender for enough time for FEP to build up onto the surface of the ring. The frame, now coated with FEP powder was hung in an air convection oven (Grieve Oven, The Grieve Corporation, Round Lake, Ill.) set at 320° C. for approx. one minute followed by air cooling to room temp.
- The NiTi frame was then set atop a filter sack and attached though the application of localized heat (the heat causing the FEP coating on the ring to re-melt and flow onto the surface of the filter sack, thus providing a biocompatible thermoplastic adhesive). The tether lines were then routed through a gold tube (Johnson Matthey, San Diego, Calif.) radiopaque marker. The tethers were pulled until they began to apply tension to the frame. A guidewire was then inserted into the gold band (from the opposite direction of the tether lines). The marker band was then crimped to secure the tethers and guidewire together. A small amount of instant adhesive (Loctite 401, Loctite Corp, Rocky Hill, Conn.) was applied to create a smooth transition from the guidewire to the OD of the gold band. One skilled in the art will realize that attachment of the filter to the guidewire could be accomplished by adhesion, welding, soldering, brazing, a combination of these, or a number of other methods.
- Upon drying, this embodiment of the endoluminal embolic filter is ready for testing.
- Various illustrative examples of the invention have been described in detail. In addition, however, many modifications and changes can be made to these examples without departing from the nature and spirit of the invention.
Claims (71)
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
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US10/113,724 US20030187495A1 (en) | 2002-04-01 | 2002-04-01 | Endoluminal devices, embolic filters, methods of manufacture and use |
EP10011979.1A EP2338439B1 (en) | 2002-04-01 | 2003-03-13 | Seamless endoluminal devices and methods of manufacture |
EP13184820.2A EP2712581B1 (en) | 2002-04-01 | 2003-03-13 | Embolic filters and methods of manufacture |
CA2648952A CA2648952C (en) | 2002-04-01 | 2003-03-13 | Endoluminal devices, embolic filters, methods of manufacture and use |
DE60332443T DE60332443D1 (en) | 2002-04-01 | 2003-03-13 | SEAMLESS ENDOLUMINARY PROSTHESIS AND FILTERS AND METHODS FOR THEIR MANUFACTURE |
CA2479776A CA2479776C (en) | 2002-04-01 | 2003-03-13 | Endoluminal devices, embolic filters, methods of manufacture and use |
EP03716545A EP1492472B1 (en) | 2002-04-01 | 2003-03-13 | Seamless endoluminal devices and methods of manufacture |
EP10001900A EP2191789B1 (en) | 2002-04-01 | 2003-03-13 | Seamless filter frame pattern and methods of manufacture |
AU2003220248A AU2003220248B2 (en) | 2002-04-01 | 2003-03-13 | Endoluminal devices, embolic filters, methods of manufacture and use |
PCT/US2003/007780 WO2003084437A2 (en) | 2002-04-01 | 2003-03-13 | Endoluminal devices, embolic filters, methods of manufacture and use |
JP2003581682A JP4426317B2 (en) | 2002-04-01 | 2003-03-13 | Intraluminal device |
CA2648948A CA2648948C (en) | 2002-04-01 | 2003-03-13 | Endoluminal devices, embolic filters, methods of manufacture and use |
US10/907,975 US8313503B2 (en) | 2002-04-01 | 2005-04-22 | Endoluminal devices |
US10/907,987 US8337520B2 (en) | 2002-04-01 | 2005-04-22 | Methods of manufacture and use of endoluminal devices |
JP2009233388A JP2010022850A (en) | 2002-04-01 | 2009-10-07 | Endoluminal device, embolic filter, and methods of manufacture and use |
HK11109722.3A HK1155345A1 (en) | 2002-04-01 | 2011-09-15 | Seamless endoluminal devices and methods of manufacture |
JP2012026474A JP2012106024A (en) | 2002-04-01 | 2012-02-09 | Endoluminal device, embolic filter, method of manufacture and use |
JP2012026404A JP5624070B2 (en) | 2002-04-01 | 2012-02-09 | Intraluminal device, embolic filter, method of manufacture and use |
JP2012173163A JP5857172B2 (en) | 2002-04-01 | 2012-08-03 | Intraluminal device |
US13/682,257 US8795322B2 (en) | 2002-04-01 | 2012-11-20 | Methods of manufacture and use of endoluminal devices |
US13/721,975 US8597322B2 (en) | 2002-04-01 | 2012-12-20 | Methods of manufacture and use of endoluminal devices |
US14/026,337 US8801750B2 (en) | 2002-04-01 | 2013-09-13 | Methods of manufacture and use of endoluminal devices |
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US10/113,724 US20030187495A1 (en) | 2002-04-01 | 2002-04-01 | Endoluminal devices, embolic filters, methods of manufacture and use |
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US10/907,987 Expired - Lifetime US8337520B2 (en) | 2002-04-01 | 2005-04-22 | Methods of manufacture and use of endoluminal devices |
US10/907,975 Expired - Lifetime US8313503B2 (en) | 2002-04-01 | 2005-04-22 | Endoluminal devices |
US13/682,257 Expired - Lifetime US8795322B2 (en) | 2002-04-01 | 2012-11-20 | Methods of manufacture and use of endoluminal devices |
US13/721,975 Expired - Lifetime US8597322B2 (en) | 2002-04-01 | 2012-12-20 | Methods of manufacture and use of endoluminal devices |
US14/026,337 Expired - Lifetime US8801750B2 (en) | 2002-04-01 | 2013-09-13 | Methods of manufacture and use of endoluminal devices |
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US13/682,257 Expired - Lifetime US8795322B2 (en) | 2002-04-01 | 2012-11-20 | Methods of manufacture and use of endoluminal devices |
US13/721,975 Expired - Lifetime US8597322B2 (en) | 2002-04-01 | 2012-12-20 | Methods of manufacture and use of endoluminal devices |
US14/026,337 Expired - Lifetime US8801750B2 (en) | 2002-04-01 | 2013-09-13 | Methods of manufacture and use of endoluminal devices |
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