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Publication numberUS20030220693 A1
Publication typeApplication
Application numberUS 10/394,008
Publication dateNov 27, 2003
Filing dateMar 24, 2003
Priority dateOct 20, 1999
Also published asUS6592625, US6984247, US6997956, US7033395, US7189235, US7670379, US7670380, US7776096, US7909879, US8048160, US20020007218, US20020111688, US20020120337, US20020151980, US20030120345, US20030163200, US20030181983, US20030187507, US20030187508, US20030220690, US20030220694, US20050149197, US20060100711, US20060129245, US20060142864, US20060161258, US20060190085, US20060241773, US20070061012, US20070156244, US20070288041, US20080033561
Publication number10394008, 394008, US 2003/0220693 A1, US 2003/220693 A1, US 20030220693 A1, US 20030220693A1, US 2003220693 A1, US 2003220693A1, US-A1-20030220693, US-A1-2003220693, US2003/0220693A1, US2003/220693A1, US20030220693 A1, US20030220693A1, US2003220693 A1, US2003220693A1
InventorsJoseph Cauthen
Original AssigneeCauthen Joseph C.
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Intervertebral disc annulus repair devices and methods
US 20030220693 A1
Abstract
A surgical method of repair and reconstruction of the spinal disc wall (annulus) after surgical invasion or pathologic rupture, incorporating suture closure, or stent insertion and fixation, designed to reduce the failure rate of conventional surgical procedures on the spinal discs.
The design of the spinal disc annulus stent allows ingrowth of normal cells of healing in an enhanced fashion strengthening the normal reparative process.
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Claims(44)
1. An annulus stent, for repair of an intervertebral disc annulus, comprising an elongated centralized vertical extension, said centralized vertical extension comprising a left and a right lateral extension along said centralized vertical extension's horizontal axis.
2. The annulus stent according to claim 1, wherein said vertical extension further comprises a slot.
3. The annulus stent according to claim 1, wherein said vertical extension is perforated.
4. The annulus stent according to claim 1, wherein said left and right lateral extensions comprise an inside edge, an outside edge, an upper surface and a lower surface, wherein said inside edge joins said centralized vertical extension to form a horizontal plane.
5. The annulus stent according to claim 4, wherein said upper surface forms an angle of about 0 to 60 degrees below said horizontal plane.
6. The annulus stent according to claim 4, wherein the length of said inside edge is less than the length of said outside edge.
7. The annulus stent according to claim 4, wherein said inside edge has a greater thickness than said outside edge.
8. The annulus stent according to claim 4, wherein said upper surface is barbed.
9. The annulus stent according to claim 4, further comprising a recess wherein said upper surface joins said centralized vertical extension.
10. The annulus stent according to claim 4, wherein said lateral extension further comprises a compressible core affixed to said lower surface.
11. The annulus stent according to claim 10, wherein said compressible core is made of a compressible biocompatible material.
12. The annulus stent according to claim 10, wherein said compressible core is made of a compressible bioreabsorbable material.
13. The annulus stent according to claim 4, further comprising a flexible bladder affixed to said lower surface of said left and right lateral extensions.
14. The annulus stent according to claim 13, wherein said flexible bladder comprises a membrane enclosing an internal cavity.
15. The annulus stent according to claim 14, wherein said internal cavity is empty.
16. The annulus stent according to claim 14, wherein said membrane comprises a thin flexible biocompatible material.
17. The annulus stent according to claim 16, wherein said membrane further comprises a semi-permeable material.
18. The annulus stent according to claim 17, wherein said internal cavity contains a biocompatible fluid.
19. The annulus stent according to claim 18, wherein said biocompatible fluid is a hydrogel.
20. The annulus stent according to claim 16, wherein said membrane further comprises an impermeable material.
21. The annulus stent according to claim 20, wherein said internal cavity contains a biocompatible fluid.
22. The annulus stent according to claim 1, wherein said centralized vertical extension is of a shape selected from the group consisting of a trapezoid, circular and curved.
23. The annulus stent according to claim 1, wherein said annulus stent is made from a material selected from the group consisting of a biocompatible material, a bioactive material, and a bioreabsorbable material.
24. The annulus stent according to claim 23, wherein said annulus stent is made from a biocompatible fiber mesh.
25. The annulus stent according to claim 23, wherein said annulus stent is made from a bioreabsorbable fiber mesh.
26. The annulus stent according to claim 23, wherein said annulus stent is made from expandable polytetra fluoroethylyene.
27. The annulus stent according to claim 1, wherein said annulus stent comprises a material to facilitate regeneration of disc tissue.
28. The annulus stent according to claim 1, wherein said annulus stent comprises a hygroscopic material.
29. An annulus patch, wherein said annulus patch is of the size and shape for repair of a intervertebral disc annulus.
30. The annulus patch according to claim 29, wherein said annulus patch is human muscle fascia, an autograft, an allograft or a xenograft.
31. A method for repairing an intervertebral disc, wherein said intervertebral disc comprises a disc nucleus and a disc annulus, comprising the steps of;
a) forming an aperture in said intervertebral disc annulus; and
b) securing across said aperture to said intervertebral disc annulus an annulus patch.
32. The method for repairing an intervertebral disc according to claim 31, wherein said annulus patch is human muscle fascia, an autograft, an allograft, or a xenograft.
33. The method for repairing an intervertebral disc according to claim 31, further comprising the step of preparing said intervertebral disc, wherein said preparation step comprises the steps;
a) identifying a damaged section of said disc nucleus; and
b) removing said damaged section of said disc nucleus.
34. A method for repairing an intervertebral disc, wherein said intervertebral disc comprises a disc nucleus and a disc annulus, comprising the steps of;
a) forming an aperture in said intervertebral disc annulus;
b) inserting an annulus stent into said aperture, wherein said annulus stent comprises an elongated centralized vertical extension, a left and a right lateral extension along said centralized vertical extension's horizontal axis; and
c) securing said annulus stent to said intervertebral disc annulus.
35. The method for repairing an intervertebral disc according to claim 34, wherein said step of forming said aperture in said disc annulus comprises the step of making a surgical incision into said disc annulus.
36. The method for repairing an intervertebral disc according to claim 34, wherein said step of inserting said annulus stent into said aperture comprises the steps of;
a) compressing said left and right lateral extensions together;
b) inserting said annulus stent into said aperture, such that an upper surface of said left and right lateral extensions conforms to an inside surface of said disc annulus; and
c) positioning said centralized vertical extension within said aperture, such that said annulus stent may be secured to said disc annulus.
37. The method for repairing an intervertebral disc according to claim 34, wherein said step of inserting said annulus stent into said aperture comprises the steps of;
a) compressing said left and right lateral extension together;
b) rotating said annulus stent, such that said annulus stent may be laterally inserted into said intervertebral disc;
c) inserting said annulus stent laterally through said aperture into said intervertebral disc;
d) rotating said annulus stent within said intervertebral disc, such that an upper surface of said left and right lateral extensions conforms to an inside surface of said disc annulus; and
e) positioning said centralized vertical extension within said aperture, such that said annulus stent may be secured to said disc annulus.
38. The method for repairing an intervertebral disc according to claim 34, further comprising a step of preparing said intervertebral disc, wherein said preparation step comprises the steps of inserting a set surgical screws into a pair of adjacent intervertebral, wherein said surgical screws comprise an eye hole located at the top of said surgical screw.
39. The method for repairing an intervertebral disc according to claim 38, wherein said step of securing said annulus stent to said intervertebral disc comprises the steps of threading a surgical suture through said eye hole on said surgical screw.
40. The method for repairing an intervertebral disc according to claim 34, further comprising the step of preparing said intervertebral disc, wherein said preparation step comprises the steps;
a) identifying a damaged section of said disc nucleus; and
b) removing said damaged section of said disc nucleus.
41. The method for repairing an intervertebral disc according to claim 40, wherein said step of inserting said annulus stent into said aperture comprises the steps of;
a) compressing said left and right lateral extensions together;
b) inserting said annulus stent into said aperture, such that an upper surface of said left and right lateral extensions conforms to an inside surface of said disc annulus;
c) positioning said centralized vertical extension within said aperture, such that said annulus stent may be secured to disc annulus; and
d) injecting a biocompatible fluid into said internal cavity, through said annulus stent.
42. The method for repairing an intervertebral disc according to claim 41, wherein said biocompatible fluid comprises a hygroscopic material.
43. The method for repairing an intervertebral disc according to claim 40, wherein said step inserting said annulus stent into said aperture comprises the steps of;
a) compressing said left and right lateral extensions together;
b) rotating said annulus stent, such that said annulus stent may be laterally inserted into said intervertebral disc;
c) inserting said annulus stent laterally through said aperture into said intervertebral disc;
d) rotating said annulus stent within said intervertebral disc, such that an upper surface of said left and right lateral extensions conforms to an inside surface of said disc annulus;
e) positioning said centralized vertical extension within said aperture, such that said annulus stent may be secured to disc annulus; and
f) inject a biocompatible fluid into said internal cavity, through said annulus stent.
44. The method for repairing an intervertebral disc according to claim 43, wherein said biocompatible fluid comprises a hygroscopic material.
Description
    CROSS-REFERENCE TO A RELATED APPLICATION
  • [0001]
    This application is a continuation of U.S. Ser. No. 09/947,078, filed Sep. 5, 2001 which is a continuation of U.S. Ser. No. 09/484,706, filed Jan. 18, 2000 which claims the benefit of U.S. Provisional Application No. 60/160,710, filed Oct. 20, 1999.
  • FIELD OF THE INVENTION
  • [0002]
    The invention generally relates to a surgical method of intervertebral disc wall reconstruction with a related annulus stent augmenting the repair. The effects of said reconstruction are restoration of disc wall integrity and reduction of the failure rate (3-21%) of a common surgical procedure (disc fragment removal or discectomy). This surgical procedure is performed about 390,000 times annually in the United States.
  • BACKGROUND OF THE INVENTION
  • [0003]
    The spinal column is formed from a number of vertebrae, which in their normal state are separated from each other by cartilaginous intervertebral discs. The intervertebral disc acts in the spine as a crucial stabilizer, and as a mechanism for force distribution between the vertebral bodies. Without the disc, collapse of the intervertebral space occurs in conjunction with abnormal joint mechanics and premature development of arthritic changes.
  • [0004]
    The normal intervertebral disc has an outer ligamentous ring called the annulus surrounding the nucleus pulposus. The annulus binds the adjacent vertebrae together and is constituted of collagen fibers that are attached to the vertebrae and cross each other so that half of the individual fibers will tighten as the vertebrae are rotated in either direction, thus resisting twisting or torsional motion. The nucleus pulposus is constituted of loose tissue, having about 85% water content, which moves about during bending from front to back and from side to side.
  • [0005]
    As people age, the annulus tends to thicken, desicate, and become more rigid. The nucleus pulposus, in turn, becomes more viscous and less fluid and sometimes even dehydrates and contracts. The annulus also becomes susceptible to fracturing or fissuring. These fractures tend to occur all around the circumference of the annulus and can extend from both the outside of the annulus inwards, and the interior outward. Occasionally, a fissure from the outside of the annulus meets a fissure from the inside and results in a complete rent or tear through the annulus fibrosis. In situations like these, the nucleus pulposus may extrude out through the annulus wall. The extruded material, in turn, can impinge on the spinal cord or on the spinal nerve rootlet as it exits through the intervertebral disc foramen, resulting in a condition termed ruptured disc or herniated disc
  • [0006]
    In the event of annulus rupture, the inner-nucleus component migrates along the path of least resistance forcing the fissure to open further, allowing migration of the nucleus pulposus through the wall of the disc, with resultant nerve compression and leakage of chemicals of inflammation into the space around the adjacent nerve roots supplying the extremities, bladder, bowel and genitalia. The usual effect of nerve compression and inflammation is intolerable back or neck pain, radiating into the extremities, with accompanying numbness, weakness, and in late stages, paralysis and muscle atrophy, and/or bladder and bowel incontinence. Additionally, injury, disease or other degenerative disorders may cause one or more of the intervertebral discs to shrink, collapse, deteriorate or become displaced, herniated, or otherwise damaged.
  • [0007]
    The surgical standard of care for treatment of herniated, displaced or ruptured intervertebral discs is fragment removal and nerve decompression without a requirement to reconstruct the annular wall. While results are currently acceptable, they are not optimal. Various authors report 3.1-21% recurrent disc herniation, representing a failure of the primary procedure and requiring re-operation for the same condition. An estimated 10% recurrence rate results in 39,000 re-operations in the United States each year.
  • [0008]
    An additional method of relieving the symptoms is thermal annuloplasty, involving the heating of sub-annular zones in the non-herniated painful disc, seeking pain relief, but making no claim of reconstruction of the ruptured, discontinuous annulus wall.
  • [0009]
    There is currently no known method of annulus reconstruction, either primarily or augmented with an annulus stent.
  • BRIEF SUMMARY OF THE INVENTION
  • [0010]
    The present invention provides methods and related materials for reconstruction of the disk wall in cases of displaced, herniated, ruptured, or otherwise damaged intervertebral discs.
  • [0011]
    In a preferred form, one or more mild biodegradable surgical sutures are placed at about equal distances along the sides of a pathologic aperture in the ruptured disc wall (annulus) or along the sides of a surgical incision in the weakened, thinned disc annulus.
  • [0012]
    Sutures are then tied in such fashion as to draw together the sides of the aperture, effecting reapproximation or closure of the opening, to enhance natural healing and subsequent reconstruction by natural tissue (fibroblasts) crossing the now surgically narrowed gap in the disc annulus.
  • [0013]
    A 25-30% reduction in the rate of recurrence of disc nucleus herniation through this aperture, has been achieved using this method.
  • [0014]
    In another embodiment, the method can be augmented by placement of a patch of human muscle fascia (the membrane covering the muscle) or any other autograft or allograft acting as a bridge in and across the aperture, providing a platform for traverse of fibroblasts or other normal cells of repair existing in and around the various layers of the disc annulus, prior to closure of the aperture.
  • [0015]
    A 30-50% reduction in the rate of recurrence of disc herniation has been achieved using the aforementioned fascial augmentation with this embodiment.
  • [0016]
    Having demonstrated that human muscle fascia is adaptable for annular reconstruction, other biocompatible membranes can be employed as a bridge, stent, patch or barrier to subsequent migration of the disc nucleus through the aperture. Such biocompatible materials may be, for example, a medical grade biocompatible fabric, biodegradable polymeric sheets, or form fitting or non-form fitting fillers for the cavity created by removal of a portion of the disc nucleus in the course of the disc fragment removal or discectomy. The prosthetic material can be placed in and around the intervertebral space, created by removal of the degenerated disc fragments.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0017]
    [0017]FIG. 1 shows a perspective view of the annulus stent.
  • [0018]
    [0018]FIG. 2 shows a front view of the annulus stent.
  • [0019]
    [0019]FIG. 3 shows a side view of the annulus stent.
  • [0020]
    FIGS. 4A-4C show a front view of various alternative embodiments of the annulus stent.
  • [0021]
    FIGS. 5A-5B shows the alternative embodiment of a pyramid shaped annulus stent.
  • [0022]
    FIGS. 6A-6B shows the alternative embodiment of a coned shaped annulus stent.
  • [0023]
    [0023]FIG. 7 shows the primary closure of the opening in the disc annulus, without an intervertebral or subannular stent.
  • [0024]
    FIGS. 8A-8B shows the primary closure with a stent in generic form.
  • [0025]
    [0025]FIG. 9 shows a method of suturing the annulus stent into the disc annulus, utilizing sub-annular fixation points.
  • [0026]
    FIGS. 10A-10B show the annulus stent with flexible bladder being expanded into the disc annulus.
  • [0027]
    FIGS. 11A-11D show the annulus stent being inserted into the disc annulus.
  • [0028]
    FIGS. 12A-12B show the annulus stent with the flexible bladder being expanded by injection.
  • DETAILED DESCRIPTION OF THE INVENTION
  • [0029]
    The present invention provides methods and related materials for reconstruction of the disk wall in cases of displaced, herniated, ruptured, or otherwise damaged intervertebral discs.
  • [0030]
    In one embodiment of the present invention, as shown in FIG. 7, a damaged annulus 42 is repaired by use of surgical sutures 40. One or more surgical sutures 40 are placed at about equal distances along the sides of a pathologic aperture 44 in the ruptured annulus 42. Reapproximation or closure of the aperture 44 is accomplished by tying the sutures 40 in such a fashion that the sides of the aperture 44 are drawn together. The reapproximation or closure of the aperture 44 enhances the natural healing and subsequent reconstruction by the natural tissue crossing the now surgically narrowed gap in the annulus 42. Preferably, the surgical sutures 40 are biodegradable, but permanent non-biodegradable may be utilized.
  • [0031]
    Additionally, to repair a weakened or thinned disc annulus 42, a surgical incision is made along the weakened or thinned region of the annulus 42 and one or more surgical sutures 40 are placed at about equal distances along the sides of the incision. Reapproximation or closure of the incision is accomplished by tying the sutures 40 in such a fashion that the sides of the incision are drawn together. The reapproximation or closure of the incision enhances the natural healing and subsequent reconstruction by the natural tissue crossing the now surgically narrowed gap in the annulus 42. Preferably, the surgical sutures 40 are biodegradable, but permanent non-biodegradable materials may be utilized.
  • [0032]
    In an alternative embodiment, the method can be augmented by the placement of a patch of human muscle fascia or any other autograft, allograft or xenograft in and across the aperture 44. The patch acts as a bridge in and across the aperture, providing a platform for traverse of fibroblasts or other normal cells of repair existing in and around the various layers of the disc annulus, prior to closure of the aperture.
  • [0033]
    In a further embodiment, as shown in FIG. 8, a biocompatible membrane can be employed as an annulus stent 10, being placed in and across the aperture 44. The annulus stent 10 acts as a bridge in and across the aperture 44, providing a platform for a traverse of fibroblasts or other normal cells of repair existing in and around the various layers of the disc annulus, prior to closure of the aperture 44.
  • [0034]
    In a preferred embodiment, as shown in FIGS. 1-3, the annulus stent 10 comprises a centralized vertical extension 12, with an upper section 14 and a lower section 16. The centralized vertical extension 12 can be trapezoid in shape through the width and may be from about 8 mm-12 mm in length.
  • [0035]
    Additionally, the upper section 14 of the centralized vertical extension 12 may be any number of different shapes, as shown in FIGS. 4A and 4B, with the sides of the upper section 14 being curved or with the upper section 14 being circular in shape. Furthermore, the annulus stent 10 may contain a recess between the upper section 14 and the lower section 16, enabling the annulus stent 10 to form a compatible fit with the edges of the aperture 44.
  • [0036]
    The upper section 14 of the centralized vertical extension 12 can comprise a slot 18, where the slot 18 forms an orifice through the upper section 14. The slot 18 is positioned within the upper section such that 14 it traverses the upper section's 14 longitudinal axis. The slot 18 is of such a size and shape that sutures, tension bands, staples or any other type of fixation device known in the art may be passed through, to affix the annulus stent 10 to the disc annulus 44.
  • [0037]
    In an alternative embodiment, the upper section 14 of the centralized vertical extension 12 may be perforated. The perforated upper section 14 contains a plurality of holes which traverse the upper section's 14 longitudinal axis. The perforations are of such a size and shape that sutures, tension bands, staples or any other type of fixation device known in the art may be passed through, to affix the annulus stent 10 to the disc annulus 44.
  • [0038]
    The lower section 16 can comprise a pair of lateral extensions, a left lateral extension 20 and a right lateral extension 22. The lateral extensions 20 and 22 comprise an inside edge 24, an outside edge 26, an upper surface 28, and a lower surface 30. The lateral extensions 20 and 22 can have an essentially constant thickness throughout. The inside edge 24 is attached to the lower section 16 and is about the same length as the lower section 16. The outside edge 26 can be about 8 mm-16 mm in length. The inside edge 24 and the lower section 16 meet to form a horizontal plane, essentially perpendicular to the centralized vertical extension 12. The upper surface 28 of the lateral extensions 20 and 22 can form an angle of about 0-60 below the horizontal plane. The width of the annulus stent 10 may be from about 3 mm-5 mm.
  • [0039]
    Additionally, the upper surface 28 of the lateral extensions 20 and 22 may be barbed for fixation to the inside surface of the disc annulus 40 and to resist expulsion through the aperture 44.
  • [0040]
    In an alternative embodiment, as shown in FIG. 4B, the lateral extensions 20 and 22 have a greater thickness at the inside edge 24 than at the outside edge 26.
  • [0041]
    In a preferred embodiment, the annulus stent 10 is a solid unit, formed from one or more of the flexible resilient biocompatible or bioresorbable materials well know in the art.
  • [0042]
    For example, the annulus stent may be made from:
  • [0043]
    a porous matrix or mesh of biocompatible and bioresorbable fibers acting as a scaffold to regenerate disc tissue and replace annulus fibrosus as disclosed in, for example, U.S. Pat. Nos. 5,108,438 (Stone) and 5,258,043 (Stone);
  • [0044]
    a strong network of inert fibers intermingled with a bioresorbable (or biosabsorable) material which attracts tissue ingrowth as disclosed in, for example, U.S. Pat. No. 4,904,260 (Ray et al.);
  • [0045]
    a biodegradable substrate as disclosed in, for example, U.S. Pat. No. 5,964,807 (Gan at al.); or
  • [0046]
    a expandable polytetrafluoroethylene (ePTFE), as used for conventional vascular grafts, such as those sold by W. L. Gore and Associates, Inc. under the trademarks GORE-TEX and PRECLUDE, or by Impra, Inc. under the trademark IMPRA.
  • [0047]
    Furthermore, the annulus stent 10, may contain hygroscopic material for a controlled limited expansion of the annulus stent 10 to fill the evacuated disc space cavity.
  • [0048]
    Additionally, the annulus stent 10 may comprise materials to facilitate regeneration of disc tissue, such as bioactive silica-based materials which assist in regeneration of disc tissue as disclosed in U.S. Pat. No. 5,849,331 (Ducheyne, et al.), or other tissue growth factors well known in the art.
  • [0049]
    In further embodiments, as shown in FIGS. 5-6, the left and right lateral extensions 20 and 22 join to form a solid pyramid or cone. Additionally, the left and right lateral extensions 20 and 22 may form a solid trapezoid, wedge, or bullet shape. The solid formation may be a solid biocompatible or bioresorbable flexible material, allowing the lateral extensions 20 and 22 to be compressed for insertion into aperture 44, then to expand conforming to the shape of the annulus' 42 inner wall.
  • [0050]
    Alternatively, a compressible core may be attached to the lower surface 30 of the lateral extensions 20 and 22, forming a pyramid, cone, trapezoid, wedge, or bullet shape. The compressible core may be made from one of the biocompatible or bioresorbable resilient foams well known in the art. The compressible core allows the lateral extensions 20 and 22 to be compressed for insertion into aperture 44, then to expand conforming to the shape of the annulus' 42 inner wall and to the cavity created by pathologic extrusion or surgical removal of the disc fragment.
  • [0051]
    In a preferred method of use, as shown in FIGS. 10A-10D, the lateral extensions 20 and 22 are compressed together for insertion into the aperture 44 of the disc annulus 40. The annulus stent 10 is then inserted into the aperture 44, where the lateral extensions 20 and 22 expand, with the upper surface 28 contouring to the inside surface of the disc annulus 40. The upper section 14 is positioned within the aperture 44 so that the annulus stent 10 may be secured to the disc annulus 40, using means well known in the art.
  • [0052]
    In an alternative method, where the length of the aperture 44 is less than the length of the outside edge 26 of the annulus stent 10, the annulus stent 10 must be inserted laterally into the aperture 44. The lateral extensions 20 and 22 are compressed, and the annulus stent 10 is laterally inserted into the aperture 44. The annulus stent 10 is then rotated inside the disc annulus 40, such that the upper section 14 is pulled back through the aperture 44. The lateral extensions 20 and 22 are then allowed to expand, with the upper surface 28 contouring to the inside surface of the disc annulus 40. The upper section 14 is positioned within the aperture 44 such that the annulus stent 10 may be secured to the disc annulus, using means well known in the art.
  • [0053]
    In an alternative method of securing the annulus stent 10 in the aperture 44, as shown in FIG. 9, a first surgical screw 50 and second surgical screw 52, with eye holes 53 located at the top of the screws 50 and 52, are opposingly inserted into the adjacent vertebrae 54 and 56 below the annulus stent 10. After insertion of the annulus stent 10 into the aperture 44, a suture is passed down though the disc annulus 40, adjacent to the aperture 44, through the eye hole 53 on the first screw 50 then back up through the disc annulus 40 and through the orifice 18 on the annulus stent 10. This is repeated for the second screw 52, after which the suture is secured. One or more surgical sutures 40 are placed at about equal distances along the sides of the aperture 44 in the disc annulus 42. Reapproximation or closure of the aperture 44 is accomplished by tying the sutures 40 in such a fashion that the sides of the aperture 44 are drawn together. The reapproximation or closure of the aperture 44 enhances the natural healing and subsequent reconstruction by the natural tissue crossing the now surgically narrowed gap in the annulus 42. Preferably, the surgical sutures 40 are biodegradable but permanent non-biodegradable forms may be utilized. This method should decrease the strain on the disc annulus 40 adjacent to the aperture 44, precluding the tearing of the sutures through the disc annulus 40.
  • [0054]
    It is anticipated that fibroblasts will engage the fibers of the polymer or fabric of the intervertebral disc stent, forming a strong wall duplicating the currently existing condition of healing seen in the normal reparative process.
  • [0055]
    In an additional embodiment, as shown in FIGS. 1A-B, a flexible bladder 60 is attached to the lower surface 30 of the annulus stent 10. The flexible bladder 60 comprises an internal cavity 62 surrounded by a membrane 64, where the membrane 64 is made from a thin flexible biocompatible material. The flexible bladder 60 is attached to the lower surface 28 of the annulus stent 10 in an unexpanded condition. The flexible bladder 60 is expanded by injecting a biocompatible fluid or expansive foam, as known in the art, into the internal cavity 62. The exact size of the flexible bladder 60 can be varied for different individuals. The typical size of an adult nucleus is 2 cm in the semi-minor axis, 4 cm in the semi-major axis and 1.2 cm in thickness.
  • [0056]
    In an alternative embodiment, the membrane 64 is made of a semi-permeable biocompatible material.
  • [0057]
    In a preferred embodiment, a hydrogel is injected into the internal cavity of the flexible bladder 28. A hydrogel is a substance formed when an organic polymer (natural or synthetic) is cross-linked via covalent, ionic, or hydrogen bonds to create a three-dimensional open-lattice structure which entraps water molecules to form a gel. The hydrogel may be used in either the hydrated or dehydrated form.
  • [0058]
    In a method of use, where the annulus stent 10 has been inserted into the aperture, as has been previously described and shown in FIGS. 12 A-b, an injection instrument, as known in the art, such as a syringe, is used to inject the biocompatible fluid or expansive foam into the internal cavity 62 of the flexible bladder 60. The biocompatible fluid or expansive foam is injected through the annulus stent 10 into the internal cavity of the flexible bladder 28. Sufficient material is injected into the internal cavity 62 to expand the flexible bladder 60 to fill the void in the intervertebral disc cavity. The use of the flexible bladder 60 is particularly useful when it is required to remove all or part of the intervertebral disc nucleus.
  • [0059]
    The surgical repair of an intervertebral disc may require the removal of the entire disc nucleus, being replaced with an implant, or the removal of a portion of the disc nucleus thereby leaving a void in the intervertebral disc cavity. The flexible bladder 60 allows for the removal of only the damaged section of the disc nucleus, with the expanded flexible bladder 60 filling the resultant void in the intervertebral disc cavity. A major advantage of the annulus stent 10 with the flexible bladder 60 is that the incision area in the annulus can be reduced in size as there is no need for the insertion of an implant into the intervertebral disc cavity.
  • [0060]
    In an alternative method of use, a dehydrated hydrogel is injected into the internal cavity 28 of the flexible bladder 60. Fluid, from the disc nucleus, passes through the semi-permeable membrane 64 hydrating the dehydrated hydrogel. As the hydrogel absorbs the fluid the flexible bladder expands 60, filling the void in the intervertebral disc cavity.
  • [0061]
    All patents referred to or cited herein are incorporated by reference in their entirety to the extent they are not inconsistent with the explicit teachings of this specification, including; U.S. Pat. No. 5,108,438 (Stone), U.S. Pat. No. 5,258,043 (Stone), U.S. Pat. No. 4,904,260 (Ray et al.), U.S. Pat. No. 5,964,807 (Gan et al.), U.S. Pat. No. 5,849,331 (Ducheyne et al.), U.S. Pat. No. 5,122,154 (Rhodes), U.S. Pat. No. 5,204,106 (Schepers at al.), U.S. Pat. No. 5,888,220 (Felt et al.) and U.S. Pat. No. 5,376,120 (Sarver et al.).
  • [0062]
    It should be understood that the examples and embodiments described herein are for illustrative purposes only and that various modifications or changes in light thereof will be suggested to persons skilled in the art and are to be included within the spirit and preview of this application and the scope of the appended claims.
Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US77701 *May 5, 1868 William youngblood
US82698 *Oct 6, 1868 Improvement in milk-vats
US3867728 *Apr 5, 1973Feb 25, 1975Cutter LabProsthesis for spinal repair
US4013078 *Oct 7, 1975Mar 22, 1977Feild James RodneyIntervertebral protector means
US4520821 *Apr 30, 1982Jun 4, 1985The Regents Of The University Of CaliforniaGrowing of long-term biological tissue correction structures in vivo
US4741330 *Apr 4, 1986May 3, 1988Hayhurst John OMethod and apparatus for anchoring and manipulating cartilage
US4772287 *Aug 20, 1987Sep 20, 1988Cedar Surgical, Inc.Prosthetic disc and method of implanting
US4852568 *Dec 28, 1987Aug 1, 1989Kensey Nash CorporationMethod and apparatus for sealing an opening in tissue of a living being
US4890612 *May 16, 1988Jan 2, 1990Kensey Nash CorporationDevice for sealing percutaneous puncture in a vessel
US4904260 *Jul 25, 1988Feb 27, 1990Cedar Surgical, Inc.Prosthetic disc containing therapeutic material
US4932969 *Dec 17, 1987Jun 12, 1990Sulzer Brothers LimitedJoint endoprosthesis
US5015255 *May 10, 1989May 14, 1991Spine-Tech, Inc.Spinal stabilization method
US5021059 *May 7, 1990Jun 4, 1991Kensey Nash CorporationPlug device with pulley for sealing punctures in tissue and methods of use
US5108438 *May 7, 1990Apr 28, 1992Regen CorporationProsthetic intervertebral disc
US5122154 *Aug 15, 1990Jun 16, 1992Rhodes Valentine JEndovascular bypass graft
US5195541 *Oct 18, 1991Mar 23, 1993Obenchain Theodore GMethod of performing laparoscopic lumbar discectomy
US5204106 *Apr 19, 1990Apr 20, 1993Fbfc International S.A.Process for restoring an osseous defect or deficiency by filling with osseous tissue
US5313962 *Mar 1, 1993May 24, 1994Obenchain Theodore GMethod of performing laparoscopic lumbar discectomy
US5320633 *Dec 10, 1992Jun 14, 1994William C. AllenMethod and system for repairing a tear in the meniscus
US5342393 *Aug 27, 1992Aug 30, 1994Duke UniversityMethod and device for vascular repair
US5344442 *May 15, 1992Sep 6, 1994Mures Cardiovasular Research, Inc.Cardiac valve
US5350399 *Oct 7, 1992Sep 27, 1994Jay ErlebacherPercutaneous arterial puncture seal device and insertion tool therefore
US5390683 *Feb 21, 1992Feb 21, 1995Pisharodi; MadhavanSpinal implantation methods utilizing a middle expandable implant
US5397331 *Nov 25, 1992Mar 14, 1995Cook IncorporatedSupporting device and apparatus for inserting the device
US5397991 *Nov 18, 1992Mar 14, 1995Electronic Development Inc.Multi-battery charging system for reduced fuel consumption and emissions in automotive vehicles
US5411520 *Feb 3, 1993May 2, 1995Kensey Nash CorporationHemostatic vessel puncture closure system utilizing a plug located within the puncture tract spaced from the vessel, and method of use
US5439464 *Mar 9, 1993Aug 8, 1995Shapiro Partners LimitedMethod and instruments for performing arthroscopic spinal surgery
US5500000 *Jul 1, 1993Mar 19, 1996United States Surgical CorporationSoft tissue repair system and method
US5507754 *Aug 20, 1993Apr 16, 1996United States Surgical CorporationApparatus and method for applying and adjusting an anchoring device
US5531759 *Apr 29, 1994Jul 2, 1996Kensey Nash CorporationSystem for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating
US5534028 *Apr 20, 1993Jul 9, 1996Howmedica, Inc.Hydrogel intervertebral disc nucleus with diminished lateral bulging
US5545178 *Oct 21, 1994Aug 13, 1996Kensey Nash CorporationSystem for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating
US5549617 *Feb 21, 1995Aug 27, 1996United States Surgical CorporationApparatus and method for applying and adjusting an anchoring device
US5549679 *Mar 1, 1995Aug 27, 1996Kuslich; Stephen D.Expandable fabric implant for stabilizing the spinal motion segment
US5556429 *May 6, 1994Sep 17, 1996Advanced Bio Surfaces, Inc.Joint resurfacing system
US5599279 *Jan 29, 1996Feb 4, 1997Gus J. SlotmanSurgical instruments and method useful for endoscopic spinal procedures
US5634944 *Feb 23, 1995Jun 3, 1997The Nemours FoundationBody membrane prosthesis
US5645597 *Dec 29, 1995Jul 8, 1997Krapiva; Pavel I.Disc replacement method and apparatus
US5649945 *Oct 17, 1994Jul 22, 1997Raymedica, Inc.Spinal anulus cutter
US5662681 *Apr 23, 1996Sep 2, 1997Kensey Nash CorporationSelf locking closure for sealing percutaneous punctures
US5716416 *Sep 10, 1996Feb 10, 1998Lin; Chih-IArtificial intervertebral disk and method for implanting the same
US5733337 *Apr 7, 1995Mar 31, 1998Organogenesis, Inc.Tissue repair fabric
US5755797 *Oct 2, 1996May 26, 1998Sulzer Medizinaltechnik AgIntervertebral prosthesis and a process for implanting such a prosthesis
US5766246 *Jan 7, 1994Jun 16, 1998C. R. Bard, Inc.Implantable prosthesis and method and apparatus for loading and delivering an implantable prothesis
US5782844 *Mar 5, 1996Jul 21, 1998Inbae YoonSuture spring device applicator
US5782860 *Feb 11, 1997Jul 21, 1998Biointerventional CorporationClosure device for percutaneous occlusion of puncture sites and tracts in the human body and method
US5785705 *Oct 24, 1995Jul 28, 1998Oratec Interventions, Inc.RF method for controlled depth ablation of soft tissue
US5788625 *Apr 5, 1996Aug 4, 1998Depuy Orthopaedics, Inc.Method of making reconstructive SIS structure for cartilaginous elements in situ
US5800549 *Apr 30, 1997Sep 1, 1998Howmedica Inc.Method and apparatus for injecting an elastic spinal implant
US5861004 *Aug 29, 1997Jan 19, 1999Kensey Nash CorporationHemostatic puncture closure system including closure locking means and method of use
US5879366 *Dec 20, 1996Mar 9, 1999W.L. Gore & Associates, Inc.Self-expanding defect closure device and method of making and using
US5888220 *Jan 23, 1996Mar 30, 1999Advanced Bio Surfaces, Inc.Articulating joint repair
US5904703 *Nov 7, 1997May 18, 1999Bard ConnaughtOccluder device formed from an open cell foam material
US5916225 *Jan 14, 1998Jun 29, 1999Surgical Sense, Inc.Hernia mesh patch
US5922028 *Oct 16, 1997Jul 13, 1999Depuy Orthopaedics, Inc.Multi-layered SIS tissue graft construct for replacement of cartilaginous elements in situ
US5928284 *Jul 9, 1998Jul 27, 1999Mehdizadeh; Hamid M.Disc replacement prosthesis
US5935147 *Dec 17, 1997Aug 10, 1999Kensey Nash CorporationHemostatic puncture closure system and method of use
US5954767 *Jul 24, 1996Sep 21, 1999C.R. Bard Inc.Curved prosthetic mesh and its method of manufacture
US6019792 *Apr 23, 1998Feb 1, 2000Cauthen Research Group, Inc.Articulating spinal implant
US6053909 *Mar 27, 1998Apr 25, 2000Shadduck; John H.Ionothermal delivery system and technique for medical procedures
US6066776 *Jul 16, 1997May 23, 2000Atrium Medical CorporationSelf-forming prosthesis for repair of soft tissue defects
US6073051 *Jun 24, 1997Jun 6, 2000Oratec Interventions, Inc.Apparatus for treating intervertebal discs with electromagnetic energy
US6095149 *Jun 24, 1997Aug 1, 2000Oratec Interventions, Inc.Method for treating intervertebral disc degeneration
US6099514 *Sep 29, 1998Aug 8, 2000Oratec Interventions, Inc.Method and apparatus for delivering or removing material from the interior of an intervertebral disc
US6171318 *Feb 11, 1999Jan 9, 2001Bard Asdi Inc.Hernia mesh patch with stiffening layer
US6179874 *Apr 23, 1999Jan 30, 2001Cauthen Research Group, Inc.Articulating spinal implant
US6183518 *Mar 23, 1999Feb 6, 2001Anthony C. RossMethod of replacing nucleus pulposus and repairing the intervertebral disk
US6187048 *May 23, 1995Feb 13, 2001Surgical Dynamics, Inc.Intervertebral disc implant
US6206921 *Feb 22, 1999Mar 27, 2001Peter A. GuaglianoMethod of replacing nucleus pulposus and repairing the intervertebral disk
US6224630 *May 29, 1998May 1, 2001Advanced Bio Surfaces, Inc.Implantable tissue repair device
US6245107 *May 28, 1999Jun 12, 2001Bret A. FerreeMethods and apparatus for treating disc herniation
US6248106 *Feb 25, 2000Jun 19, 2001Bret FerreeCross-coupled vertebral stabilizers
US6280453 *Feb 11, 1999Aug 28, 2001Bard Asdi Inc.Hernia mesh patch with stiffener line segment
US6340369 *Aug 14, 2000Jan 22, 2002Bret A. FerreeTreating degenerative disc disease with harvested disc cells and analogues of the extracellular matrix
US6344058 *Aug 14, 2000Feb 5, 2002Bret A. FerreeTreating degenerative disc disease through transplantation of allograft disc and vertebral endplates
US6352557 *Aug 14, 2000Mar 5, 2002Bret A. FerreeTreating degenerative disc disease through transplantion of extracellular nucleus pulposus matrix and autograft nucleus pulposus cells
US6371990 *Oct 16, 2000Apr 16, 2002Bret A. FerreeAnnulus fibrosis augmentation methods and apparatus
US6402750 *Apr 4, 2000Jun 11, 2002Spinlabs, LlcDevices and methods for the treatment of spinal disorders
US6425919 *Jun 30, 2000Jul 30, 2002Intrinsic Orthopedics, Inc.Devices and methods of vertebral disc augmentation
US6425924 *Mar 31, 2000Jul 30, 2002Ethicon, Inc.Hernia repair prosthesis
US6428576 *Apr 14, 2000Aug 6, 2002Endospine, Ltd.System for repairing inter-vertebral discs
US6447531 *Jul 10, 2000Sep 10, 2002Aga Medical CorporationMethod of forming medical devices; intravascular occlusion devices
US6452924 *Nov 15, 1999Sep 17, 2002Enron Warpspeed Services, Inc.Method and apparatus for controlling bandwidth in a switched broadband multipoint/multimedia network
US6506204 *Dec 29, 2000Jan 14, 2003Aga Medical CorporationMethod and apparatus for occluding aneurysms
US6508828 *Nov 3, 2000Jan 21, 2003Radi Medical Systems AbSealing device and wound closure device
US6530933 *Sep 15, 1999Mar 11, 2003Teresa T. YeungMethods and devices for fastening bulging or herniated intervertebral discs
US6726696 *Jun 28, 2002Apr 27, 2004Advanced Catheter Engineering, Inc.Patches and collars for medical applications and methods of use
US6783546 *Mar 22, 2001Aug 31, 2004Keraplast Technologies, Ltd.Implantable prosthetic or tissue expanding device
US7033393 *Apr 30, 2003Apr 25, 2006Raymedica, Inc.Self-transitioning spinal disc anulus occulsion device and method of use
US20020077701 *Dec 17, 2001Jun 20, 2002Kuslich Stephen D.Annulus-reinforcing band
US20020082698 *Sep 18, 2001Jun 27, 2002Parenteau Nancy L.Method for treating a patient using a cultured connective tissue construct
US20030040796 *Jun 26, 2002Feb 27, 2003Ferree Bret A.Devices used to treat disc herniation and attachment mechanisms therefore
US20030074075 *Aug 27, 2002Apr 17, 2003Thomas James C.Expandable implant for partial disc replacement and reinforcement of a disc partially removed in a discectomy and for reduction and maintenance of alignment of cancellous bone fractures and methods and apparatuses for same
US20040054414 *Sep 18, 2002Mar 18, 2004Trieu Hai H.Collagen-based materials and methods for augmenting intervertebral discs
US20040092969 *Sep 26, 2002May 13, 2004Kumar Sarbjeet S.Device and method for surgical repair of abdominal wall hernias
US20040138703 *Sep 5, 2003Jul 15, 2004Neville AlleyneSeal for posterior lateral vertebral disk cavity
US20060195193 *Feb 22, 2006Aug 31, 2006Aesculap Ag & Co. KgImplant for closing an opening in the annulus fibrosus
US20070067040 *Nov 17, 2006Mar 22, 2007Anova CorporationMethods and apparatus for reconstructing the anulus fibrosus
US20070100349 *Oct 27, 2005May 3, 2007O'neil MichaelNucleus augmentation delivery device and technique
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US7442210Jul 1, 2005Oct 28, 2008Jerome SegalMechanical apparatus and method for artificial disc replacement
US7547319Feb 22, 2006Jun 16, 2009Ouroboros MedicalMechanical apparatus and method for artificial disc replacement
US7601172Nov 14, 2005Oct 13, 2009Ouroboros Medical, Inc.Mechanical apparatus and method for artificial disc replacement
US7824414Jul 22, 2005Nov 2, 2010Kensey Nash CorporationSystem and devices for the repair of a vertebral disc defect
US7857857Nov 10, 2005Dec 28, 2010The Board Of Trustees Of The Leland Stanford Junior UniversityDevices, systems and methods for augmenting intervertebral discs
US7883527Oct 31, 2007Feb 8, 2011Nuvasive, Inc.Annulotomy closure device and related methods
US7901430Mar 11, 2005Mar 8, 2011Nuvasive, Inc.Annulotomy closure device and related methods
US8021426Jun 15, 2005Sep 20, 2011Ouroboros Medical, Inc.Mechanical apparatus and method for artificial disc replacement
US8070818Mar 27, 2009Dec 6, 2011Jmea CorporationDisc annulus repair system
US8114161Feb 17, 2006Feb 14, 2012Kensey Nash CorporationSystem and devices for the repair of a vertebral disc defect
US8128698Oct 14, 2008Mar 6, 2012Anulex Technologies, Inc.Method and apparatus for the treatment of the intervertebral disc annulus
US8163022Sep 3, 2009Apr 24, 2012Anulex Technologies, Inc.Method and apparatus for the treatment of the intervertebral disc annulus
US8177847Nov 5, 2009May 15, 2012Jmea CorporationDisc repair system
US8211126Sep 22, 2009Jul 3, 2012Jmea CorporationTissue repair system
US8317868Mar 7, 2012Nov 27, 2012Jmea CorporationDisc repair system
US8454690Sep 17, 2010Jun 4, 2013William T. MCCLELLANSystems and methods for tissue expansion with fluid delivery and drainage system
US8454697Apr 5, 2012Jun 4, 2013Anulex Technologies, Inc.Method and apparatus for the treatment of tissue
US8460319Aug 10, 2010Jun 11, 2013Anulex Technologies, Inc.Intervertebral disc annulus repair system and method
US8535380May 13, 2010Sep 17, 2013Stout Medical Group, L.P.Fixation device and method
US8556977Nov 12, 2010Oct 15, 2013Anulex Technologies, Inc.Tissue anchoring system and method
US8603118May 16, 2012Dec 10, 2013Jmea CorporationTissue repair system
US8632590Sep 26, 2006Jan 21, 2014Anulex Technologies, Inc.Apparatus and methods for the treatment of the intervertebral disc
US8652153Aug 10, 2010Feb 18, 2014Anulex Technologies, Inc.Intervertebral disc annulus repair system and bone anchor delivery tool
US8702718Nov 2, 2007Apr 22, 2014Jmea CorporationImplantation system for tissue repair
US8709042Mar 21, 2007Apr 29, 2014Stout Medical Group, LPExpandable support device and method of use
US8758351Feb 14, 2012Jun 24, 2014Kensey Nash CorporationSystem and devices for the repair of a vertebral disc defect
US8795364May 6, 2005Aug 5, 2014Kensey Nash CorporationSystem and devices for the repair of a vertebral disc defect
US8961530Nov 8, 2013Feb 24, 2015Jmea CorporationImplantation system for tissue repair
US9005250Nov 2, 2010Apr 14, 2015Kensey Nash CorporationSystem and devices for the repair of a vertebral disc defect
US9044335May 5, 2010Jun 2, 2015Cornell UniversityComposite tissue-engineered intervertebral disc with self-assembled annular alignment
US9050112Aug 22, 2012Jun 9, 2015Flexmedex, LLCTissue removal device and method
US9095442Jan 23, 2012Aug 4, 2015Krt Investors, Inc.Method and apparatus for the treatment of the intervertebral disc annulus
US9114025Jun 29, 2011Aug 25, 2015Krt Investors, Inc.Methods and devices for spinal disc annulus reconstruction and repair
US9149286Nov 14, 2011Oct 6, 2015Flexmedex, LLCGuidance tool and method for use
US9192372Jun 3, 2013Nov 24, 2015Krt Investors, Inc.Method for the treatment of tissue
US9259329Nov 20, 2013Feb 16, 2016Stout Medical Group, L.P.Expandable support device and method of use
US9277903Oct 31, 2007Mar 8, 2016Nuvasive, Inc.Annulotomy closure device and related methods
US9314349Mar 21, 2007Apr 19, 2016Stout Medical Group, L.P.Expandable support device and method of use
US20060253132 *Feb 17, 2006Nov 9, 2006International Business Machines CorporationSystem and devices for the repair of a vertebral disc defect
US20060253152 *May 6, 2005Nov 9, 2006Evans Douglas GSystem and devices for the repair of a vertebral disc defect
US20060287726 *Jun 15, 2005Dec 21, 2006Jerome SegalMechanical apparatus and method for artificial disc replacement
US20070043374 *Jul 22, 2005Feb 22, 2007Evans Douglas GSystem and devices for the repair of a vertebral disc defect
US20070162135 *Jan 31, 2007Jul 12, 2007Jerome SegalMechanical apparatus and method for artificial disc replacement
US20070233252 *Feb 23, 2007Oct 4, 2007Kim Daniel HDevices, systems and methods for treating intervertebral discs
US20080065218 *Sep 13, 2006Mar 13, 2008O'neil Michael JAnnulus fibrosus repair devices and techniques
US20080172126 *Oct 3, 2006Jul 17, 2008Reynolds Martin ANucleus pulposus injection devices and methods
US20110046649 *Nov 2, 2010Feb 24, 2011Evans Douglas GSystem and devices for the repair of a vertebral disc defect
US20110153017 *Sep 17, 2010Jun 23, 2011Mcclellan William TSystems and methods for tissue expansion with fluid delivery and drainage system
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