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Publication numberUS20030236484 A1
Publication typeApplication
Application numberUS 10/350,317
Publication dateDec 25, 2003
Filing dateJan 23, 2003
Priority dateApr 26, 1999
Also published asCA2368314A1, CA2368335A1, CA2368335C, CA2368342A1, CA2368354A1, CA2368354C, CA2648346A1, CA2648346C, CN1354642A, DE60019740D1, DE60019740T2, DE60025715D1, DE60025715T2, DE60037406D1, DE60037406T2, DE60042853D1, EP1173123A1, EP1173124A1, EP1173124B1, EP1173125A1, EP1173125B1, EP1173126A1, EP1173126B1, EP1477146A2, EP1477146A3, EP1477146B1, EP2027837A2, EP2027837A3, EP2027837B1, EP2116215A2, EP2116215A3, EP2116215B1, EP2260804A2, EP2260804A3, US6450984, US6464724, US6524275, US6626858, US6783544, US6827699, US6827700, US7850637, US8152752, US8388568, US8771217, US20030009124, US20030069637, US20030220602, US20030220603, US20040260228, US20050090806, US20050090807, US20100004580, US20110196281, US20150148730, WO2000064389A1, WO2000064390A1, WO2000064390A9, WO2000064391A1, WO2000064393A1
Publication number10350317, 350317, US 2003/0236484 A1, US 2003/236484 A1, US 20030236484 A1, US 20030236484A1, US 2003236484 A1, US 2003236484A1, US-A1-20030236484, US-A1-2003236484, US2003/0236484A1, US2003/236484A1, US20030236484 A1, US20030236484A1, US2003236484 A1, US2003236484A1
InventorsMary Lynch, Reay Brown
Original AssigneeGmp Vision Solutions, Inc.
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Inflatable device and method for treating glaucoma
US 20030236484 A1
Abstract
Catheter devices and methods for treating glaucoma and other eye diseases by expandable dilatation of Schlemm's canal and/or direct injection of medications into Schlemm's canal.
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Claims(20)
What is claimed is:
1. A catheter device comprising a proximal portion manually controllable by a user, a distal portion sized and shaped for circumferential insertion into a portion of Schlemm's canal, and an inflation supply lumen extending from the proximal portion to the distal portion, wherein the distal portion of the inflationary lumen is expandable and moves between a first Schlemm's canal insertion position and a second Schlemm's canal inflation position when inflated.
2. The catheter device of claim 1, further comprising a guiding lumen extending from the proximal portion to the distal portion, wherein the guiding lumen contains a steerable guidewire for directing the catheter device into a desired length of Schlemm's canal.
3. The catheter device of claim 1, further comprising a medicament delivery lumen extending from the proximal portion to the distal portion, wherein the medicament delivery lumen has at least one fenestration therein on the distal portion for the delivery of medicaments into Schlemm's canal.
4. The catheter device of claim 1, wherein the distal portion has a diameter of about 0.1 to 0.5 mm.
5. The catheter device of claim 1, wherein the distal portion has a diameter of about 0.3 mm.
6. The catheter device of claim 1, wherein the distal portion has a length of about 1.0 to 20.0 mm.
7. The catheter device of claim 1, wherein the distal portion has a pre-formed curvature having a radius which approximates the radius of Schlemm's canal of a human eye.
8. The catheter device of claim 1, wherein the distal portion has a pre-formed curvature having a radius of between about 3 mm and 10 mm.
9. The catheter device of claim 1, wherein the distal portion has a pre-formed curvature having a radius of about 6 mm.
10. A catheter device comprising a proximal portion manually controllable by a user, a distal portion sized and shaped for circumferential insertion into a portion of Schlemm's canal, and a medicament delivery lumen extending from the proximal portion to the distal portion, wherein the medicament delivery lumen has at least one fenestration therein on the distal portion for the delivery of medicaments into Schlemm's canal.
11. The catheter device of claim 10, further comprising a guiding lumen extending from the proximal portion to the distal portion, wherein the guiding lumen contains a steerable guidewire for directing the catheter device into a desired length of Schlemm's canal.
12. The catheter device of claim 10, further comprising an inflation supply lumen extending from the proximal portion to the distal portion, wherein the distal portion of the inflation supply lumen is expandable and moves between a first insertion position and a second inflation position when inflated.
13. The catheter device of claim 10, wherein the distal portion has a diameter of about 0.1 to 0.5 mm.
14. The catheter device of claim 10, wherein the distal portion has a diameter of about 0.3 mm.
15. The catheter device of claim 10, wherein the distal portion has a length of about 1.0 to 20.0 mm.
16. The catheter device of claim 10, wherein the distal portion has a pre-formed curvature having a radius which approximates the radius of Schlemm's canal of a human eye.
17. The catheter device of claim 10, wherein the distal portion has a pre-formed curvature having a radius of between about 3 mm and 10 mm.
18. The catheter device of claim 10, wherein the distal portion has a pre-formed curvature having a radius of about 6 mm.
19. A method for the surgical treatment of glaucoma and other diseases, comprising inserting the catheter device of claim 1 into Schlemm's canal and expanding the canal by inflating the distal portion of the inflation lumen.
20. A method for the surgical treatment of glaucoma and other diseases, comprising inserting the catheter device of claim 10 into Schlemm's canal and delivering a medicament into the canal through the at least one fenestration in the distal portion of the medicament delivery lumen.
Description
    CROSS-REFERENCE TO RELATED APPLICATIONS
  • [0001]
    This application claims the benefit of U.S. Provisional Application No. 60/131,030, filed Apr. 26, 1999.
  • TECHNICAL FIELD
  • [0002]
    The present invention is generally directed to a surgical treatment for glaucoma and other eye diseases and relates more particularly to an inflatable device and method for use in ophthalmic surgery to mechanically dilate Schlemm's canal in the eye and/or instill medications within Schlemm's canal for direct action upon the canal, the trabecular meshwork, and adjacent tissues.
  • BACKGROUND OF THE INVENTION
  • [0003]
    Glaucoma is a significant public health problem, because glaucoma is a major cause of blindness. The blindness that results from glaucoma involves both central and peripheral vision and has a major impact on an individual's ability to lead an independent life.
  • [0004]
    Glaucoma is an optic neuropathy (a disorder of the optic nerve) that usually occurs in the setting of an elevated intraocular pressure. The pressure within the eye increases and this is associated with changes in the appearance (“cupping”) and function (“blind spots” in the visual field) of the optic nerve. If the pressure remains high enough for a long enough period of time, total vision loss occurs. High pressure develops in an eye because of an internal fluid imbalance.
  • [0005]
    The eye is a hollow structure that contains a clear fluid called “aqueous humor.” Aqueous humor is formed in the posterior chamber of the eye by the ciliary body at a rate of about 2.5 microliters per minute. The fluid, which is made at a fairly constant rate, then passes around the lens, through the pupillary opening in the iris and into the anterior chamber of the eye. Once in the anterior chamber, the fluid drains out of the eye through two different routes. In the “uveoscleral” route, the fluid percolates between muscle fibers of the ciliary body. This route accounts for ten percent of the aqueous outflow. The primary pathway for aqueous outflow is through the “canalicular” route that involves the trabecular meshwork and Schlemm's canal.
  • [0006]
    The trabecular meshwork and Schlemm's canal are located at the junction between the iris and the sclera. This junction or corner is called “the angle.” The trabecular meshwork is a wedge-shaped structure that runs around the circumference of the eye. It is composed of collagen beams arranged in a three-dimensional sieve-like structure. The beams are lined with a monolayer of cells called trabecular cells. The spaces between the collagen beams are filled with an extracellular substance that is produced by the trabecular cells. These cells also produce enzymes that degrade the extracellular material. Schlemm's canal is adjacent to the trabecular meshwork. The outer wall of the trabecular meshwork coincides with the inner wall of Schlemm's canal. Schlemm's canal is a tube-like structure that runs around the circumference of the cornea. In human adults, Schlemm's canal is believed to be divided by septa into a series of autonomous, dead-end canals.
  • [0007]
    The aqueous fluid travels through the spaces between the trabecular beams, across the inner wall of Schlemm's canal into the canal, through a series of collecting channels that drain from Schlemm's canal and into the episcleral venous system. In a normal situation, aqueous production is equal to aqueous outflow and intraocular pressure remains fairly constant in the 15 to 21 mm Hg range. In glaucoma, the resistance through the canalicular outflow system is abnormally high.
  • [0008]
    In primary open angle glaucoma, which is the most common form of glaucoma, the abnormal resistance is believed to be along the outer aspect of trabecular meshwork and the inner wall of Schlemm's canal. It is believed that an abnormal metabolism of the trabecular cells leads to an excessive build up of extracellular materials or a build up of abnormally “stiff” materials in this area. Primary open angle glaucoma accounts for approximately eighty-five percent of all glaucoma. Other forms of glaucoma (such as angle closure glaucoma and secondary glaucomas) also involve decreased outflow through the canalicular pathway but the increased resistance is from other causes such as mechanical blockage, inflammatory debris, cellular blockage, etc.
  • [0009]
    With the increased resistance, the aqueous fluid builds up because it cannot exit fast enough. As the fluid builds up, the intraocular pressure (IOP) within the eye increases. The increased IOP may compromise the vascular supply to the optic nerve that carries vision from the eye to the brain. Some optic nerves seem more susceptible to IOP than other eyes. While research is investigating ways to protect the nerve from an elevated pressure, the only therapeutic approach currently available in glaucoma is to reduce the intraocular pressure.
  • [0010]
    The clinical treatment of glaucoma is approached in a step-wise fashion. Medication often is the first treatment option. Administered either topically or orally, these medications work to either reduce aqueous production or they act to increase outflow. Currently available medications have many serious side effects including: congestive heart failure, respiratory distress, hypertension, depression, renal stones, aplastic anemia, sexual dysfunction and death. Compliance with medication is a major problem, with estimates that over half of glaucoma patients do not follow their correct dosing schedules.
  • [0011]
    When medication fails to adequately reduce the pressure, laser trabeculoplasty often is performed. In laser trabeculoplasty, thermal energy from a laser is applied to a number of noncontiguous spots in the trabecular meshwork. It is believed that the laser energy stimulates the metabolism of the trabecular cells in some way, and changes the extracellular material in the trabecular meshwork. In approximately eighty percent of patients, aqueous outflow is enhanced and IOP decreases. However, the effect often is not long lasting and fifty percent of patients develop an elevated pressure within five years. The laser surgery is not usually repeatable. In addition, laser trabeculoplasty is not an effective treatment for primary open angle glaucoma in patients less than fifty years of age, nor is it effective for angle closure glaucoma and many secondary glaucomas.
  • [0012]
    If laser trabeculoplasty does not reduce the pressure enough, then filtering surgery is performed. With filtering surgery, a hole is made in the sclera and angle region. This hole allows the aqueous fluid to leave the eye through an alternate route.
  • [0013]
    The most commonly performed filtering procedure is a trabeculectomy. In a trabeculectomy, a posterior incision is made in the conjunctiva, the transparent tissue that covers the sclera. The conjunctiva is rolled forward, exposing the sclera at the limbus. A partial thickness scleral flap is made and dissected half-thickness into the cornea. The anterior chamber is entered beneath the scleral flap and a section of deep sclera and trabecular meshwork is excised. The scleral flap is loosely sewn back into place. The conjunctival incision is tightly closed. Post-operatively, the aqueous fluid passes through the hole, beneath the scleral flap and collects in an elevated space beneath the conjunctiva. The fluid then is either absorbed through blood vessels in the conjunctiva or traverses across the conjunctiva into the tear film.
  • [0014]
    Trabeculectomy is associated with many problems. Fibroblasts that are present in the episclera proliferate and migrate and can scar down the scleral flap. Failure from scarring may occur, particularly in children and young adults. Of eyes that have an initially successful trabeculectomy, eighty percent will fail from scarring within three to five years after surgery. To minimize fibrosis, surgeons now are applying antifibrotic agents such as mitomycin C (MMC) and 5-fluorouracil (5-FU) to the scleral flap at the time of surgery. The use of these agents has increased the success rate of trabeculectomy but also has increased the prevalence of hypotony. Hypotony is a problem that develops when aqueous flows out of the eye too fast. The eye pressure drops too low (usually less than 6.0 mmHg); the structure of the eye collapses and vision decreases.
  • [0015]
    An alternative surgical method for glaucoma management can be directed more specifally at Schlemm's canal. U.S. Pat. No. 5,360,399 teaches the placement of part of a plastic or steel tube into Schlemm's canal with injection of a viscous material through holes in the tube to hydraulically hydrodissect the trabecular meshwork. However, the '399 device provides little or no option for the distance of the hydrodissection within the length of Schlemm's canal, nor suggests a means for dilating the canal to facilitate the natural drainage therefrom.
  • [0016]
    A need exists, then, for a system that would allow for precise dilation and expansion of Schlemm's canal along any portion thereof. A need exists for the selective, direct delivery of therapeutic agents into Schlemm's canal that provides more effective control of glaucoma with fewer systemic complications than with existing medication delivery alternatives. In addition, a more physiologic system is needed to enhance the drainage of aqueous fluid into Schlemm's canal from the anterior chamber angle. Enhancing aqueous flow directly into Schlemm's canal would minimize scarring since the angle region is populated with a single line of nonproliferating trabecular cells. Enhancing aqueous flow directly into Schlemm's canal and naturally therefrom into the collecting channels would minimize hypotony since the canal is part of the normal outflow system and is biologically engineered to handle the normal volume of aqueous humor. Enhancing aqueous flow directly into Schlemm's canal would eliminate complications such as endophthalmitis, hypotony, and leaks.
  • SUMMARY OF THE INVENTION
  • [0017]
    The present invention is directed to a novel inflatable catheter device and an associated method for the surgical correction of glaucoma in which the inventive device is placed within Schlemm's canal and the inflatable element of the device is expanded to temporarily stretch and expand the lumen of the canal. At that point, the inflatable element may be used to temporarily occlude outflow through the canal, while physiologic material is injected through another lumen of the device, thereby distending the canal and expanding areas of stenosis within the canal. The inflated element may be decompressed and removed after the desired expansion is achieved, or the device may be extracted with the inflatable component expanded, to further mechanically dilate the passageway within Schlemm's canal.
  • [0018]
    The present invention may also be employed to inject various medications directly within Schlemm's canal. Such medications may include, but are not limited to, antifibrotics, antibiotics, and other medications which may have direct effects within the internal structures of Schlemm's canal, the trabecular meshwork, and other tissues of the eye. The present invention may also be employed to deploy various stents or shunts directly within Schlemm's canal to help maintain patency within the canal following removal of the inflatable device.
  • [0019]
    The inventive device and method described herein therefore facilitates the normal physiologic pathway for drainage of aqueous humor from the anterior chamber to Schlemm's canal and exiting to the collecting channels, rather than shunting to the sclera or another anatomic site as is done in most prior art devices. In addition, the present invention provides a mechanism for the delivery of devices or medications directly into Schlemm's canal and the adjacent ophthalmic anatomy.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0020]
    [0020]FIG. 1 is an illustration showing an overall view of one embodiment of the present invention, in which the inventive device is comprised of a dual, concentric lumen catheter with an outer lumen terminating in an inflatable sleeve, and an inner lumen which protrudes distal to the inflatable sleeve and terminates in an open tip. FIG. 1 further shows a guidewire which extends throughout the length of said catheter.
  • [0021]
    [0021]FIG. 2 is an illustration showing a cross sectional view at point A-A′ as shown on FIG. 1 and detailing the concentric nature of the two lumens within this embodiment of the present invention.
  • [0022]
    [0022]FIG. 3 is an illustration showing a detail of the distal portion of one embodiment of the present invention in which the inventive catheter is configured with the inflatable sleeve operated by the external lumen, and with the internal lumen protruding distally to the inflatable sleeve and containing a plurality of fenestrations before terminating in a blunted tip.
  • [0023]
    [0023]FIG. 4 is an illustration showing another possible embodiment of the inventive catheter in which the inflatable sleeve is operated by the internal lumen, and with the external lumen extending to the origin of the inflatable sleeve and containing a plurality of fenestrations.
  • [0024]
    [0024]FIG. 5 is an illustration showing the relevant anatomic details of the human eye.
  • [0025]
    [0025]FIG. 6 is an illustration showing the anatomic relationships of the surgical placement of an exemplary embodiment of the present invention within Schlemm's canal.
  • [0026]
    [0026]FIG. 7 is a schematic illustration showing the effects on Schlemm's canal (exaggerated for purposes of this illustration) of injection of a medicament by one embodiment of the inventive catheter.
  • [0027]
    [0027]FIG. 8 is a schematic illustration showing the effects on Schlemm's canal (exaggerated for purposes of this illustration) of injection of a medicament by one embodiment of the inventive catheter.
  • DETAILED DESCRIPTION OF THE PRESENT INVENTION
  • [0028]
    The present invention provides catheter devices for the dilatation of Schlemm's canal of the eye by mechanically distending a portion of the canal when inflated. The inflatable catheter devices may also be used to provide a conduit capable of delivering therapeutic and/or expansive medicaments injected therethrough into Schlemm's canal. The inflatable catheter devices may also be used to provide a delivery mechanism for stents, shunts and the like into Schlemm's canal to maintain patency within the canal to facilitate the natural drainage of aqueous humor. Furthermore, optical fibers, cameras, temperature sensors, pressure sensors, and any other probe or suitable useful device can be delivered to within Schlemm's canal by the present invention.
  • [0029]
    The invention provides a catheter device comprising a proximal portion manually controllable by a user, and a distal portion shaped and sized for circumferential insertion into a portion of Schlemm's canal. The device further comprises an inflation supply lumen extending from the proximal portion to the distal portion. The distal portion of the inflation supply lumen can be constructed of a resilient, expandable material for radially dilating a portion of Schlemm's canal when inflated. Inflation can be achieved by gas or liquid injection into the proximal portion of the inflation supply lumen, and can be carefully monitored for volume and pressure so as to accurately expand the distal lumen of the catheter device to the desired amount, Therefore, the distal portion of the inflationary lumen can move between a first insertion position and a second inflation position when inflated via the proximal portion.
  • [0030]
    It has not been heretofore determined that Schlemm's canal is patent throughout its circumference in normal individuals, as opposed to being divided by septa into multiple dead end canals. The invention utilizes this new knowledge to access Schlemm's canal and to create and maintain patency within the canal with the present devices.
  • [0031]
    The proximal portion of the catheter device is designed to receive a connector for attachment of an inflation means, such as an injection syringe or pump. The device can also comprise a guiding lumen extending from the proximal portion to the distal portion, wherein the guiding lumen contains a steerable guidewire for directing the catheter device into a desired length of Schlemm's canal.
  • [0032]
    In some embodiments, the catheter device can provide medicinal compositions therethrough for deposit into Schlemm's canal. This can be achieved by utilizing a single lumen with one or more openings or fenestrations in the distal portion thereof. In some cases, the delivery of a medicament may itself be an inert material, such as a gel, to expand and dilate the canal sufficiently, thereby providing a therapeutic effect. Alternatively, the catheter device can have a separate medicament delivery lumen and an inflation lumen, as described above. In certain embodiments, the inflation lumen is concentrically located at a site along the distal portion to provide occlusion of Schlemm's canal either distally or proximally to the material injected.
  • [0033]
    The present invention is directed to devices and surgical methods for dilating Schlemm's canal and/or for delivering topically active medications directly into Schlemm's canal utilizing an inflatable device that is surgically inserted within at least a portion of Schlemm's canal. The portion of the device extending circumferentially into Schlemm's canal may be fashioned from a flexible, biologically inert material. The distal portion of the catheter device has a diameter approximately equal to that of Schlemm's canal of a human eye. The external diameter of the distal portion can be between about 0.1 and 0.5 mm, or preferably about 0.3 mm. The length of the distal portion can be between about 1.0 and 20 mm, or preferably about 10 mm. The distal portion of the catheter device can have a pre-formed curve having a radius approximately equal to that of Schlemm's canal. The radius of the distal portion can be between about 3 and 10 mm, or preferably about 6 mm.
  • [0034]
    One embodiment of the present invention is illustrated in FIG. 1, in which the shunt device 100 is shown in a side view. The shunt device 100 is comprised of two portions, a proximal portion 30 which joins one or more distal portions 40. The proximal portion 30 is tubular, containing one or more lumens in either a concentric or parallel internal configuration. In the exemplary embodiment of the present invention, the proximal portion 30 is constructed of a biologically inert, flexible material such as silicone or similar polymers. Alternate materials might include, but are not limited to, thin-walled Teflon, polypropylene, or other polymers or plastics.
  • [0035]
    At its proximal end, the proximal portion 30 is attached to a connector 25 which provides fluid communication between one or more lumens within the proximal portion 30 and standard connectors for medical syringe attachment. In the exemplary embodiment of the present invention, the connector provides such communication with separate subconnectors 10 and 20. Subconnector 10 terminally connects to syringe attachment 5, which provides a connection for a syringe [not shown] used to inject materials into one or more communicating lumens within the proximal portion 30. Subconnector 20 terminally connects to syringe attachment 15, which provides a connection for a syringe [not shown] used to inject materials into one or more communicating lumens within the proximal portion 30. Subconnector 20 may also allow passage therethrough for a guidewire 71 with a blunted tip 72.
  • [0036]
    The proximal portion 30 of the catheter connects with the distal portion 40. The lumen(s) of the proximal portion 30 each connect with a corresponding lumen within the distal portion 40. The distal portion 40 is sized and shaped to be received within Schlemm's canal in the eye. In an alternate embodiment, the distal portion 40 may be a continuous, tapering extension of the proximal portion 30. The distal portion 40 terminates in a tip 70 which may be tapered and/or blunted, and may be open or closed. In the embodiment shown in FIG. 1, the distal tip of the guidewire 72 extends slightly beyond the tip 70 of the distal portion 40 of the device. In the embodiment shown in FIG. 1, the distal portion has a concentric inflatable sleeve 50. In an alternate embodiment, distal to the inflatable sleeve 50, the distal portion 40 may continue as a fenestrated catheter 60, containing one or more fenestrations 65.
  • [0037]
    [0037]FIG. 2 shows a cross section at point A-A′ through the embodiment of the present invention as indicated in FIG. 1. In this embodiment, a concentric, dual lumen catheter is provided, with an outer tube 44 and an inner tube 48. An outer tube lumen 45 is defined between the walls of the outer tube 44 and the inner tube 48. An inner tube lumen 49 is present within the inner tube 48.
  • [0038]
    A longitudinal cross-section detailing the terminal aspect of the distal portion 40 in this embodiment of the present invention is shown in FIG. 3. In this embodiment, the outer tube 44 is continuous with the inflatable sleeve 50, and the outer tube 44 terminates in a sealed end 55 at the distal end of the inflatable sleeve 50. The inner tube 48 extends through the center of the inflatable sleeve 50, and continues distal to the inflatable sleeve 50 as the fenestrated catheter 60. In the present embodiment, the fenestrated catheter 60 contains a plurality of fenestrations. 65, and terminates in a blunted, sealed distal catheter tip 70.
  • [0039]
    In an alternate embodiment of the present invention, as shown in FIG. 4, the inflatable sleeve 50 is continuous as a terminal extension of the inner tube 48, and the device terminates in a blunted distal catheter tip 70 just distal to the inflatable sleeve 50. In this embodiment of the present invention, the outer tube 44 is continuous with the fenestrated catheter 60 terminally, such that the fenestrations 65 communicate with the outer lumen 45. In this embodiment, the inflatable sleeve 50 is controlled through the inner lumen 49, which is in continuous communication with the lumen of the inflatable sleeve 50. Any materials intended to be injected into Schlemm's canal are introduced through the outer lumen 45, and pass through the fenestrations 65 into Schlemm's canal proximal to the inflatable sleeve 50.
  • [0040]
    The surgical anatomy relevant to the present invention is illustrated in FIG. 5. Generally, FIG. 5 shows Schlemm's canal 110 and the pupil 120, with the anatomic relationship of those structures to the anterior chamber 135, the iris 140, cornea 145, trabecular meshwork 150, and lens 170.
  • [0041]
    The surgical placement and functionality of the present invention is shown from a frontal perspective in FIGS. 6-8. FIG. 6 shows the use of an embodiment like that shown in FIG. 3, in which the inflatable sleeve 50 is proximal to the fenestrated catheter 60. The distal portion 40 of the device is threaded into Schlemm's canal 110 through a surgical incision 105, such that the inflatable sleeve 50 is entirely received into the canal 110.
  • [0042]
    The guidewire 71 may be used during surgical placement of the device to afford temporary rigidity to the device to facilitate its placement. Once placement is achieved, the guidewire 71 may be withdrawn, leaving the device 100 in the desired anatomic position.
  • [0043]
    Once the distal portion 40 of the catheter is satisfactorily placed within Schlemm's canal 110, the inflatable sleeve 50 is inflated by an injection of liquid material or air through the outer lumen 45 of the catheter. The inflation of the inflatable sleeve 50 serves to seal Schlemm's canal 110. Subsequent injection of a desired material through the inner lumen 49 of the catheter is expressed through the fenestrated catheter 60, causing local expansion of Schlemm's canal 110 distal to the inflatable sleeve 50.
  • [0044]
    [0044]FIG. 8 shows the functionality of an embodiment like that shown previously in FIG. 4, in which the inflatable sleeve 50 is located terminally, and the fenestrations 65 are in the wall of the outer tube 44 towards the catheter tip. When the inflatable sleeve 50 is inflated by injection into the inner tube 48, Schlemm's canal 110 is effectively sealed distal to the inflated sleeve 50. Subsequent injection of a desired material through the outer lumen 45 of the catheter is expressed through the fenestrated catheter 60, causing local expansion of Schlemm's canal 110 proximal to the inflatable sleeve 50.
  • [0045]
    The surgical procedure necessary to insert the device requires an approach through a fornix-based conjunctival flap. A partial thickness scleral flap is then created and dissected half-thickness into clear cornea. A radial incision is made at the limbus beneath the scleral flap and deepened until Schlemm's canal is entered posteriorly. The anterior chamber may be deepened with injection of a viscoelastic and a miotic agent. The distal portion of the catheter device is grasped and threaded into Schlemm's canal. At the desired position, the catheter device is inflated to expand Schlemm's canal. The device is then deflated and withdrawn. The scleral flap and conjunctival wound are closed in a conventional manner.
  • [0046]
    While the above-described embodiments are exemplary, the invention contemplates a wide variety of shapes and configurations of the catheter to provide fluid communication between the anterior chamber and Schlemm's canal. The above-described embodiments are therefore not intended to be limiting to the scope of the claims and equivalents thereof.
Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US3788327 *Mar 30, 1971Jan 29, 1974Donowitz HSurgical implant device
US4037604 *Jan 5, 1976Jul 26, 1977Newkirk John BArtifical biological drainage device
US4175563 *Oct 5, 1977Nov 27, 1979Arenberg Irving KBiological drainage shunt
US4299227 *Oct 19, 1979Nov 10, 1981Lincoff Harvey AOphthalmological appliance
US4402681 *Sep 10, 1981Sep 6, 1983Haas Joseph SArtificial implant valve for the regulation of intraocular pressure
US4428746 *Jul 29, 1981Jan 31, 1984Antonio MendezGlaucoma treatment device
US4457757 *Jul 20, 1981Jul 3, 1984Molteno Anthony C BDevice for draining aqueous humour
US4501274 *Mar 12, 1982Feb 26, 1985Finn SkjaerpeMicrosurgical instrument
US4521210 *Dec 27, 1982Jun 4, 1985Wong Vernon GEye implant for relieving glaucoma, and device and method for use therewith
US4554918 *Jul 28, 1982Nov 26, 1985White Thomas COcular pressure relief device
US4604087 *Jun 21, 1985Aug 5, 1986Joseph Neil HAqueous humor drainage device
US4634418 *Apr 6, 1984Jan 6, 1987Binder Perry SHydrogel seton
US4718907 *Jun 20, 1985Jan 12, 1988Atrium Medical CorporationVascular prosthesis having fluorinated coating with varying F/C ratio
US4733665 *Nov 7, 1985Mar 29, 1988Expandable Grafts PartnershipExpandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4750901 *Mar 5, 1987Jun 14, 1988Molteno Anthony C BImplant for drainage of aqueous humour
US4787885 *Mar 6, 1987Nov 29, 1988Binder Perry SHydrogel seton
US4800890 *Dec 26, 1985Jan 31, 1989Cramer Bernhard MSteerable guide wire for catheters
US4846172 *May 26, 1987Jul 11, 1989Berlin Michael SLaser-delivery eye-treatment method
US4863457 *Apr 22, 1988Sep 5, 1989Lee David ADrug delivery device
US4900300 *Feb 24, 1989Feb 13, 1990Lee David ASurgical instrument
US4936825 *Apr 11, 1988Jun 26, 1990Ungerleider Bruce AMethod for reducing intraocular pressure caused by glaucoma
US4946436 *Nov 17, 1989Aug 7, 1990Smith Stewart GPressure-relieving device and process for implanting
US5041081 *May 18, 1990Aug 20, 1991Odrich Ronald BOcular implant for controlling glaucoma
US5092837 *Aug 27, 1990Mar 3, 1992Robert RitchMethod for the treatment of glaucoma
US5095887 *Sep 10, 1990Mar 17, 1992Claude LeonMicroscope-endoscope assembly especially usable in surgery
US5127901 *Jan 31, 1991Jul 7, 1992Odrich Ronald BImplant with subconjunctival arch
US5129895 *May 16, 1990Jul 14, 1992Sunrise Technologies, Inc.Laser sclerostomy procedure
US5178604 *May 31, 1990Jan 12, 1993Iovision, Inc.Glaucoma implant
US5180362 *Apr 3, 1990Jan 19, 1993Worst J G FGonio seton
US5246451 *Apr 30, 1991Sep 21, 1993Medtronic, Inc.Vascular prosthesis and method
US5300020 *Sep 30, 1992Apr 5, 1994Medflex CorporationSurgically implantable device for glaucoma relief
US5318513 *Sep 24, 1992Jun 7, 1994Leib Martin LCanalicular balloon fixation stent
US5334137 *Feb 21, 1992Aug 2, 1994Eagle Vision, Inc.Lacrimal fluid control device
US5338291 *Feb 3, 1993Aug 16, 1994Pudenz-Schulte Medical Research CorporationGlaucoma shunt and method for draining aqueous humor
US5346464 *Apr 14, 1993Sep 13, 1994Camras Carl BMethod and apparatus for reducing intraocular pressure
US5397300 *Apr 21, 1994Mar 14, 1995Iovision, Inc.Glaucoma implant
US5433701 *Dec 21, 1994Jul 18, 1995Rubinstein; Mark H.Apparatus for reducing ocular pressure
US5454796 *Mar 10, 1993Oct 3, 1995Hood LaboratoriesDevice and method for controlling intraocular fluid pressure
US5486165 *Jan 13, 1994Jan 23, 1996Stegmann; RobertMethod and appliance for maintaining the natural intraocular pressure
US5520631 *Jul 22, 1994May 28, 1996Wound Healing Of OklahomaMethod and apparatus for lowering the intraocular pressure of an eye
US5557453 *Nov 17, 1995Sep 17, 1996Leica Mikroskopie Und Systeme GmbhMicroscope that displays superimposed data
US5558629 *Jul 21, 1992Sep 24, 1996Iovision, Inc.Glaucoma implant
US5558630 *Dec 30, 1994Sep 24, 1996Fisher; Bret L.Intrascleral implant and method for the regulation of intraocular pressure
US5601094 *Nov 22, 1994Feb 11, 1997Reiss; George R.Ophthalmic shunt
US5601549 *Nov 2, 1995Feb 11, 1997Machida Endoscope Co., Ltd.Medical observing instrument
US5626558 *May 5, 1995May 6, 1997Suson; JohnAdjustable flow rate glaucoma shunt and method of using same
US5626559 *May 1, 1995May 6, 1997Ramot University Authority For Applied Research And Industrial Development Ltd.Ophthalmic device for draining excess intraocular fluid
US5639278 *Nov 13, 1995Jun 17, 1997Corvita CorporationExpandable supportive bifurcated endoluminal grafts
US5651783 *Dec 20, 1995Jul 29, 1997Reynard; MichaelFiber optic sleeve for surgical instruments
US5670161 *May 28, 1996Sep 23, 1997Healy; Kevin E.Biodegradable stent
US5676679 *Jun 13, 1996Oct 14, 1997University Of MiamiApparatus for implanting an artifical meshwork in glaucoma surgery
US5681275 *Jan 26, 1996Oct 28, 1997Ahmed; Abdul MateenOphthalmological device with adaptable multiple distribution plates
US5704904 *Feb 26, 1997Jan 6, 1998Antigee Advantage International, Inc.Inflatable lumber traction vest
US5704907 *Dec 11, 1995Jan 6, 1998Wound Healing Of OklahomaMethod and apparatus for lowering the intraocular pressure of an eye
US5713844 *Jan 10, 1997Feb 3, 1998Peyman; Gholam A.Device and method for regulating intraocular pressure
US5723005 *Jun 7, 1995Mar 3, 1998Herrick Family Limited PartnershipPunctum plug having a collapsible flared section and method
US5741333 *Apr 3, 1996Apr 21, 1998Corvita CorporationSelf-expanding stent for a medical device to be introduced into a cavity of a body
US5743868 *Feb 14, 1994Apr 28, 1998Brown; Reay H.Corneal pressure-regulating implant device
US5752928 *Jul 14, 1997May 19, 1998Rdo Medical, Inc.Glaucoma pressure regulator
US5766243 *Jul 31, 1996Jun 16, 1998Oasis Medical, Inc.Abrasive polished canalicular implant
US5785674 *Dec 20, 1996Jul 28, 1998Mateen; Ahmed AbdulDevice and method for treating glaucoma
US5807302 *Apr 1, 1996Sep 15, 1998Wandel; ThaddeusTreatment of glaucoma
US5810870 *Jun 7, 1995Sep 22, 1998W. L. Gore & Associates, Inc.Intraluminal stent graft
US5865831 *Apr 17, 1996Feb 2, 1999Premier Laser Systems, Inc.Laser surgical procedures for treatment of glaucoma
US5868697 *Mar 27, 1996Feb 9, 1999Optonol Ltd.Intraocular implant
US5879319 *Jun 20, 1995Mar 9, 1999Chauvin OpsiaSclerotomy implant
US5882327 *Apr 17, 1997Mar 16, 1999Jacob; Jean T.Long-term glaucoma drainage implant
US5891084 *Jan 27, 1997Apr 6, 1999Lee; Vincent W.Multiple chamber catheter delivery system
US5893837 *Feb 28, 1997Apr 13, 1999Staar Surgical Company, Inc.Glaucoma drain implanting device and method
US5968058 *Jul 14, 1997Oct 19, 1999Optonol Ltd.Device for and method of implanting an intraocular implant
US6033434 *Jun 7, 1996Mar 7, 2000Ave Galway LimitedBifurcated endovascular stent and methods for forming and placing
US6045557 *Nov 10, 1996Apr 4, 2000Baxter International Inc.Delivery catheter and method for positioning an intraluminal graft
US6050970 *May 8, 1997Apr 18, 2000Pharmacia & Upjohn CompanyMethod and apparatus for inserting a glaucoma implant in an anterior and posterior segment of the eye
US6059772 *Jan 8, 1997May 9, 2000Candela CorporationApparatus and method for treating glaucoma using a gonioscopic laser trabecular ablation procedure
US6059812 *Mar 6, 1998May 9, 2000Schneider (Usa) Inc.Self-expanding medical device for centering radioactive treatment sources in body vessels
US6063116 *Apr 24, 1995May 16, 2000Medarex, Inc.Modulation of cell proliferation and wound healing
US6063396 *Feb 12, 1996May 16, 2000Houston Biotechnology IncorporatedMethods and compositions for the modulation of cell proliferation and wound healing
US6071286 *Jun 23, 1997Jun 6, 2000Mawad; Michel E.Combination angioplasty balloon/stent deployment device
US6077299 *Jun 22, 1998Jun 20, 2000Eyetronic, LlcNon-invasively adjustable valve implant for the drainage of aqueous humor in glaucoma
US6102045 *Dec 24, 1997Aug 15, 2000Premier Laser Systems, Inc.Method and apparatus for lowering the intraocular pressure of an eye
US6168575 *Jan 29, 1998Jan 2, 2001David Pyam SoltanpourMethod and apparatus for controlling intraocular pressure
US6174305 *Nov 3, 1998Jan 16, 2001Endocare, Inc.Urological stent therapy system and method
US6193656 *Feb 8, 1999Feb 27, 2001Robert E. JeffriesIntraocular pressure monitoring/measuring apparatus and method
US6197056 *Mar 2, 1998Mar 6, 2001Ras Holding Corp.Segmented scleral band for treatment of presbyopia and other eye disorders
US6228873 *Jun 8, 1998May 8, 2001The Regents Of The University Of CaliforniaMethod for enhancing outflow of aqueous humor in treatment of glaucoma
US6231597 *Feb 16, 1999May 15, 2001Mark E. DeemApparatus and methods for selectively stenting a portion of a vessel wall
US6241721 *Oct 9, 1998Jun 5, 2001Colette CozeanLaser surgical procedures for treatment of glaucoma
US6266182 *Feb 29, 2000Jul 24, 2001Olympus Optical Co., Ltd.Operating microscope
US6268398 *Apr 23, 1999Jul 31, 2001MitokorCompounds and methods for treating mitochondria-associated diseases
US6342058 *Jan 21, 2000Jan 29, 2002Valdemar PortneyIris fixated intraocular lens and instrument for attaching same to an iris
US6375642 *Feb 15, 2000Apr 23, 2002Grieshaber & Co. Ag SchaffhausenMethod of and device for improving a drainage of aqueous humor within the eye
US6464724 *Apr 26, 2000Oct 15, 2002Gmp Vision Solutions, Inc.Stent device and method for treating glaucoma
US6533768 *Apr 14, 2000Mar 18, 2003The Regents Of The University Of CaliforniaDevice for glaucoma treatment and methods thereof
US20020013546 *Sep 17, 2001Jan 31, 2002Grieshaber & Co. Ag SchaffhausenMethod and device to improve aqueous humor drainage in an eye
US20020026200 *Aug 21, 2001Feb 28, 2002Savage James A.Method and apparatus for treatment of glaucoma
US20020072673 *Dec 11, 2000Jun 13, 2002Yamamoto Ronald K.Treatment of ocular disease
US20020082591 *Nov 29, 2001Jun 27, 2002Eduard HaefligerDevice for the treatment of glaucoma
US20020133168 *Mar 18, 2002Sep 19, 2002Smedley Gregory T.Applicator and methods for placing a trabecular shunt for glaucoma treatment
US20020143284 *Nov 8, 2001Oct 3, 2002Hosheng TuDrug-releasing trabecular implant for glaucoma treatment
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US7291125Nov 14, 2003Nov 6, 2007Transcend Medical, Inc.Ocular pressure regulation
US7708711Nov 12, 2003May 4, 2010Glaukos CorporationOcular implant with therapeutic agents and methods thereof
US7740604Sep 24, 2007Jun 22, 2010Ivantis, Inc.Ocular implants for placement in schlemm's canal
US7815592Apr 22, 2008Oct 19, 2010Transcend Medical, Inc.Ocular pressure regulation
US7850637Nov 12, 2004Dec 14, 2010Glaukos CorporationShunt device and method for treating glaucoma
US7850638Dec 22, 2006Dec 14, 2010Transcend Medical, Inc.Ocular pressure regulation
US7857782Feb 5, 2009Dec 28, 2010Glaukos CorporationOcular implant delivery system and method thereof
US7867186Aug 5, 2003Jan 11, 2011Glaukos CorporationDevices and methods for treatment of ocular disorders
US7867205May 6, 2005Jan 11, 2011Glaukos CorporationMethod of delivering an implant for treating an ocular disorder
US7879001Aug 8, 2007Feb 1, 2011Glaukos CorporationDevices and methods for treatment of ocular disorders
US7879079Jun 19, 2006Feb 1, 2011Glaukos CorporationImplant delivery system and methods thereof for treating ocular disorders
US7951155May 31, 2011Glaukos CorporationCombined treatment for cataract and glaucoma treatment
US8007459Dec 18, 2008Aug 30, 2011Glaukos CorporationOcular implant with anchoring mechanism and multiple outlets
US8062244Feb 5, 2009Nov 22, 2011Glaukos CorporationSelf-trephining implant and methods thereof for treatment of ocular disorders
US8075511Apr 28, 2008Dec 13, 2011Glaukos CorporationSystem for treating ocular disorders and methods thereof
US8109896Feb 11, 2008Feb 7, 2012Optonol Ltd.Devices and methods for opening fluid passageways
US8118768Oct 6, 2008Feb 21, 2012Dose Medical CorporationDrug eluting ocular implant with anchor and methods thereof
US8128588Dec 22, 2006Mar 6, 2012Transcend Medical, Inc.Ocular pressure regulation
US8142364Jan 4, 2010Mar 27, 2012Dose Medical CorporationMethod of monitoring intraocular pressure and treating an ocular disorder
US8152752Nov 12, 2004Apr 10, 2012Glaukos CorporationShunt device and method for treating glaucoma
US8167939Sep 26, 2011May 1, 2012Transcend Medical, Inc.Ocular implant with stiffness qualities, methods of implantation and system
US8172899Sep 26, 2011May 8, 2012Transcend Medical, Inc.Ocular implant with stiffness qualities, methods of implantation and system
US8262726Oct 5, 2010Sep 11, 2012Transcend Medical, Inc.Ocular implant with stiffness qualities, methods of implantation and system
US8267882Sep 18, 2012Ivantis, Inc.Methods and apparatus for treating glaucoma
US8273050Jul 12, 2004Sep 25, 2012Glaukos CorporationOcular implant with anchor and therapeutic agent
US8282592May 6, 2010Oct 9, 2012Ivantis, Inc.Glaucoma treatment method
US8313454Mar 26, 2010Nov 20, 2012Optonol Ltd.Fluid drainage device, delivery device, and associated methods of use and manufacture
US8333742Dec 18, 2012Glaukos CorporationMethod of delivering an implant for treating an ocular disorder
US8337445Sep 25, 2007Dec 25, 2012Glaukos CorporationOcular implant with double anchor mechanism
US8337509Dec 7, 2009Dec 25, 2012Ivantis, Inc.Methods and apparatus for delivering ocular implants into the eye
US8348877May 3, 2010Jan 8, 2013Dose Medical CorporationOcular implant with therapeutic agents and methods thereof
US8372026Feb 3, 2012Feb 12, 2013Ivantis, Inc.Ocular implant architectures
US8377122Jan 27, 2010Feb 19, 2013Transcend Medical, Inc.Ocular implant with stiffness qualities, methods of implantation and system
US8388568May 7, 2009Mar 5, 2013Glaukos CorporationShunt device and method for treating ocular disorders
US8414518Mar 21, 2012Apr 9, 2013Ivantis, Inc.Glaucoma treatment method
US8425449Jul 9, 2010Apr 23, 2013Ivantis, Inc.Ocular implants and methods for delivering ocular implants into the eye
US8425473Jan 23, 2009Apr 23, 2013Iscience Interventional CorporationSubretinal access device
US8444588Feb 23, 2010May 21, 2013Transcend Medical, Inc.Internal shunt and method for treating glaucoma
US8486000Nov 12, 2004Jul 16, 2013Transcend Medical, Inc.Ocular pressure regulation
US8506515Nov 9, 2007Aug 13, 2013Glaukos CorporationUveoscleral shunt and methods for implanting same
US8512404Nov 20, 2007Aug 20, 2013Ivantis, Inc.Ocular implant delivery system and method
US8529492Dec 20, 2010Sep 10, 2013Trascend Medical, Inc.Drug delivery devices and methods
US8529494Sep 11, 2012Sep 10, 2013Ivantis, Inc.Methods and apparatus for treating glaucoma
US8551166Nov 19, 2012Oct 8, 2013Ivantis, Inc.Methods and apparatus for delivering ocular implants into the eye
US8574294Dec 16, 2010Nov 5, 2013Transcend Medical, Inc.Ocular implant with stiffness qualities, methods of implantation and system
US8579846Nov 21, 2011Nov 12, 2013Glaukos CorporationOcular implant systems
US8617094Jan 12, 2006Dec 31, 2013Glaukos CorporationFluid infusion methods for glaucoma treatment
US8617139Jun 25, 2009Dec 31, 2013Transcend Medical, Inc.Ocular implant with shape change capabilities
US8657776Jun 14, 2011Feb 25, 2014Ivantis, Inc.Ocular implants for delivery into the eye
US8663150Dec 19, 2011Mar 4, 2014Ivantis, Inc.Delivering ocular implants into the eye
US8672870Jul 17, 2008Mar 18, 2014Transcend Medical, Inc.Ocular implant with hydrogel expansion capabilities
US8721656Dec 22, 2006May 13, 2014Transcend Medical, Inc.Glaucoma treatment device
US8728021Dec 17, 2010May 20, 2014Transcend Medical, Inc.Ocular pressure regulation
US8734377Sep 23, 2008May 27, 2014Ivantis, Inc.Ocular implants with asymmetric flexibility
US8734378Sep 17, 2009May 27, 2014Transcend Medical, Inc.Glaucoma treatment device
US8747299Jun 2, 2011Jun 10, 2014Grieshaber Ophtalmic Research FoundationMethod and device for the pathology analysis of the Schlemm's canal
US8758289Dec 17, 2010Jun 24, 2014Transcend Medical, Inc.Ocular pressure regulation
US8771217Dec 13, 2010Jul 8, 2014Glaukos CorporationShunt device and method for treating ocular disorders
US8771218Dec 17, 2010Jul 8, 2014Transcend Medical, Inc.Ocular pressure regulation
US8801649Oct 5, 2010Aug 12, 2014Transcend Medical, Inc.Glaucoma treatment device
US8801766Nov 15, 2010Aug 12, 2014Aquesys, Inc.Devices for deploying intraocular shunts
US8808220Oct 14, 2010Aug 19, 2014Transcend Medical, Inc.Ocular pressure regulation
US8808222Aug 22, 2013Aug 19, 2014Ivantis, Inc.Methods and apparatus for delivering ocular implants into the eye
US8814819Dec 16, 2010Aug 26, 2014Transcend Medical, Inc.Glaucoma treatment device
US8814820Sep 20, 2012Aug 26, 2014Glaukos CorporationOcular implant with therapeutic agent and methods thereof
US8845572Nov 13, 2009Sep 30, 2014Grieshaber Ophthalmic Research FoundationMethod and device for the treatment of glaucoma
US8852136Dec 8, 2011Oct 7, 2014Aquesys, Inc.Methods for placing a shunt into the intra-scleral space
US8852256Nov 15, 2010Oct 7, 2014Aquesys, Inc.Methods for intraocular shunt placement
US8882781May 27, 2011Nov 11, 2014Glaukos CorporationCombined treatment for cataract and glaucoma treatment
US8945038May 17, 2013Feb 3, 2015Transcend Medical, Inc.Internal shunt and method for treating glaucoma
US8951221Aug 20, 2009Feb 10, 2015Grieshaber Ophthalmic Research FoundationMethod and device for the treatment of glaucoma
US8961447Feb 25, 2013Feb 24, 2015Ivantis, Inc.Glaucoma treatment method
US8974511Nov 15, 2010Mar 10, 2015Aquesys, Inc.Methods for treating closed angle glaucoma
US9017276Jul 26, 2013Apr 28, 2015Aquesys, Inc.Shunt placement through the sclera
US9039650Apr 7, 2014May 26, 2015Ivantis, Inc.Ocular implants with asymmetric flexibility
US9050169Jul 14, 2014Jun 9, 2015Ivantis, Inc.Methods and apparatus for delivering ocular implants into the eye
US9066750Jan 2, 2014Jun 30, 2015Ivantis, Inc.Delivering ocular implants into the eye
US9066782Dec 17, 2012Jun 30, 2015Dose Medical CorporationOcular implant with therapeutic agents and methods thereof
US9066783Aug 15, 2013Jun 30, 2015Ivantis, Inc.Methods and apparatus for treating glaucoma
US9084662Jan 17, 2007Jul 21, 2015Transcend Medical, Inc.Drug delivery treatment device
US9089392Aug 23, 2013Jul 28, 2015Transcend Medical, Inc.Drug delivery devices and methods
US9095411Nov 15, 2010Aug 4, 2015Aquesys, Inc.Devices for deploying intraocular shunts
US9095413Jun 3, 2014Aug 4, 2015Aquesys, Inc.Intraocular shunt manufacture
US9113994Jun 3, 2014Aug 25, 2015Aquesys, Inc.Intraocular shunt manufacture
US9125723Feb 19, 2013Sep 8, 2015Aquesys, Inc.Adjustable glaucoma implant
US9155654Feb 17, 2012Oct 13, 2015Glaukos CorporationOcular system with anchoring implant and therapeutic agent
US9155655Dec 23, 2013Oct 13, 2015Ivantis, Inc.Ocular implants for delivery into the eye
US9155656Feb 10, 2014Oct 13, 2015Transcend Medical, Inc.Delivery system for ocular implant
US9173774Sep 11, 2012Nov 3, 2015Optonol Ltd.Fluid drainage device, delivery device, and associated methods of use and manufacture
US9173775Mar 14, 2013Nov 3, 2015Glaukos CorporationSystem for delivering multiple ocular implants
US9192516Feb 26, 2014Nov 24, 2015Aquesys, Inc.Intraocular shunt placement
US9211213Apr 18, 2013Dec 15, 2015Ivantis, Inc.Ocular implants and methods for delivering ocular implants into the eye
US9220632Dec 20, 2013Dec 29, 2015Glaukos CorporationFluid infusion methods for ocular disorder treatment
US9226852Apr 21, 2015Jan 5, 2016Ivantis, Inc.Methods and apparatus for delivering ocular implants into the eye
US9241832Apr 18, 2013Jan 26, 2016Transcend Medical, Inc.Delivery system for ocular implant
US20070106236 *Dec 22, 2006May 10, 2007Coroneo Minas TOcular Pressure Regulation
US20090204053 *Feb 11, 2008Aug 13, 2009Optonol Ltd.Devices and methods for opening fluid passageways
US20100100104 *Nov 17, 2009Apr 22, 2010Aquesys, Inc.Systems for reducing pressure in an organ
US20100121249 *Nov 17, 2009May 13, 2010Aquesys, Inc.Methods for reducing pressure in an organ
US20100191103 *Mar 9, 2010Jul 29, 2010Iscience Interventional CorporationApparatus and method for surgical bypass of aqueous humor
US20110046536 *Aug 20, 2009Feb 24, 2011Grieshaber Ophthalmic Research FoundationMethod and device for the treatment of glaucoma
US20110118649 *Nov 13, 2009May 19, 2011Grieshaber Ophthalmic Research FoundationMethod and device for the treatment of glaucoma
US20110118745 *Dec 9, 2010May 19, 2011Aquesys, Inc.Methods, systems and apparatus for relieving pressure in an organ
US20130096552 *Apr 18, 2013Christopher L. BraceHydrodissection Material with Reduced Migration
EP2529660A1May 31, 2012Dec 5, 2012Grieshaber Ophthalmic Research FoundatonDevice for the pathology analysis of the schlemm's canal
WO2010085672A1 *Jan 22, 2010Jul 29, 2010Iscience Interventional CorporationDevice for aspirating fluids
WO2015046856A1 *Sep 23, 2014Apr 2, 2015사회복지법인 삼성생명공익재단Device for treating ocular diseases caused by increased intraocular pressure
Classifications
U.S. Classification604/8, 606/107
International ClassificationA61F2/84, A61M25/00, A61F2/00, A61F9/00, A61F9/007
Cooperative ClassificationA61M2210/0612, A61M25/0074, A61M25/007, A61M25/0068, A61F2250/0067, A61F2230/0052, A61F9/00781, A61F9/0017
European ClassificationA61M25/00T10, A61F9/007V
Legal Events
DateCodeEventDescription
Jan 30, 2007ASAssignment
Owner name: GLAUKOS CORPORATION, CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:GMP VISION SOLUTIONS, INC.;REEL/FRAME:018828/0019
Effective date: 20070119