|Publication number||US20040098131 A1|
|Application number||US 10/713,837|
|Publication date||May 20, 2004|
|Filing date||Nov 14, 2003|
|Priority date||Jul 22, 1996|
|Also published as||CA2202453A1, CA2202453C, DE69725932D1, DE69725932T2, EP0820740A1, EP0820740B1, EP1166725A2, EP1166725A3, EP1166725B1, US5674296, US5865846, US6001130, US6156067, USRE42480, USRE42576|
|Publication number||10713837, 713837, US 2004/0098131 A1, US 2004/098131 A1, US 20040098131 A1, US 20040098131A1, US 2004098131 A1, US 2004098131A1, US-A1-20040098131, US-A1-2004098131, US2004/0098131A1, US2004/098131A1, US20040098131 A1, US20040098131A1, US2004098131 A1, US2004098131A1|
|Inventors||Vincent Bryan, Alex Kunzler|
|Original Assignee||Sdgi Holdings, Inc.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (99), Referenced by (106), Classifications (75)|
|External Links: USPTO, USPTO Assignment, Espacenet|
 This application is a continuation of U.S. patent application Ser. No. 09/776,394 entitled “HUMAN SPINAL DISC PROSTHESIS” filed on Feb. 2, 2001, which is a reissue application of the U.S. Pat. No. 5,865,846 entitled “HUMAN SPINAL DISC PROSTHESIS” filed on May 15, 1997, each of which is hereby incorporated by reference.
 This invention relates generally to human prostheses, and especially to spinal column vertebral disc prostheses. The invention also relates to surgical procedures for preparing the patient to receive a vertebral disc endoprosthesis, and for implanting that endoprosthesis in the patient's spine.
 The herniation of a spinal disc and the often resultant symptoms of intractable pain, weakness, sensory loss, incontinence and progressive arthritis are among the most common of debilitating processes affecting mankind. If a patient's condition does not improve after conservative treatment, and if clear physical evidence of nerve root or spinal cord compression is apparent, and if correlating radiographic studies (i.e., MRI or CT imaging or myelography) confirm the condition, surgical removal of the herniated disc may be indicated. The process of discectomy—as the name implies—involves the simple removal of the disc without attempt to replace or repair the malfunctioning unit. In the United States in 1985, over 250,000 such operations were performed in the lumbar spine and in the cervical spine.
 Statistics suggest that present surgical techniques are likely to result in short-term relief, but will not prevent the progressive deterioration of the patient's condition in the long run. Through better pre-operative procedures and diagnostic studies, long-term patient results have improved somewhat. But it has become clear that unless the removed disc is replaced or the spine is otherwise properly supported, further degeneration of the patient's condition will almost certainly occur.
 In the mid-1950's and 60's, Cloward and Smith & Robinson popularized anterior surgical approaches to the cervical spine for the treatment of cervical degenerative disc disease and related disorders of the vertebrae, spinal cord and nerve root; these surgeries involved disc removal followed by interbody fusion with a bone graft. It was noted by Robinson (Robinson, R. A.: The Results of Anterior Interbody Fusion of the Cervical Spine, J. Bone Joint Surg., 440A: 1569-1586, 1962) that after surgical fusion, osteophyte (bone spur) reabsorption at the fused segment might take place. However, it has become increasingly apparent that unfused vertebral segments at the levels above and below the fused segment degenerate at accelerated rates as a direct result of this fusion. This has led some surgeons to perform discectomy alone, without fusion, by a posterior approach in the neck of some patients. However, as has occurred in surgeries involving the lower back where discectomy without fusion is more common as the initial treatment for disc herniation syndromes, progressive degeneration at the level of disc excision is the rule rather than the exception. Premature degenerative disc disease at the level above and below the excised disc can and does occur.
 Spine surgery occasionally involves fusion of the spine segments. In addition to the problems created by disc herniation, traumatic, malignant, infectious and degenerative syndromes of the spine can be treated by fusion. Other procedures can include bone grafts and heavy duty metallic rods, hooks, plates and screws being appended to the patient's anatomy; often they are rigidly and internally fixed. None provide for a patient's return to near-normal functioning. Though these procedures may solve a short-term problem, they can cause other, longer term, problems.
 A number of attempts have been made to solve some of the problems described above by providing a patient with spinal disc prostheses, or artificial discs of one sort or another. For example, Steffee, U.S. Pat. No. 5,031,437, describes a spinal disc prosthesis having upper and lower rigid flat plates and a flat elastomeric core sandwiched between the plates. Frey et al., U.S. Pat. Nos. 4,917,704 and 4,955,908, disclose intervertebral prostheses, but the prostheses are described as solid bodies.
 U.S. Pat. Nos. 4,911,718 and 5,171,281 disclose resilient disc spacers, but no inter-connective or containing planes or like elements are suggested, and sealing the entire unit is not taught.
 It is the primary aim of the present invention to provide a vertebral disc endoprosthesis which will perform effectively and efficiently within a patient's spine over a long period of time, and which will not encourage degeneration of or cause damage to adjacent natural disc parts.
 It is another object to provide a vertebral disc endoprosthesis which does not require pins or other common mechanical hinge elements, yet which permits natural motion of the prosthetic parts and the adjacent natural anatomy.
 It is a related objective to provide a new vertebral disc endoprosthesis surgical procedure which will decrease post-operative recovery time and inhibit post-operative disc, vertebral body and spinal joint degeneration.
 It is yet another object to provide a method of installing the endoprosthesis so as to accurately mate the endoprosthesis with an adjacent specifically formed bone surface. An associated object is to provide an endoprosthesis which will encourage bone attachment to, and growth upon, adjacent outer surfaces of the endoprosthesis.
 Yet another object is to provide a vertebral endoprosthesis in which the parts are non-oncogenic.
 Still another object is to provide a vertebral disc endoprosthesis having a resilient element to accommodate shocks and other forces applied to the spine.
 Another object is to provide a highly effective vertebral endoprosthesis which includes several disc endoprostheses and one or more prosthetic vertebral bodies. A related object is to provide these elements in a pre-assembled array for implantation in a patient.
 To accomplish these objects, the invention comprises a resilient body formed of a material varying in stiffness from a relatively stiff exterior portion to a relatively supple central portion. A concaval-convex means at least partly surrounds that resilient body so as to retain the resilient body between adjacent vertebral bodies of a patient's spine. If medical considerations so indicate, several disc endoprostheses can be combined with one or more endoprosthetic vertebral bodies in an entire assembly.
 To implant this endoprosthesis assembly, information is obtained regarding the size, shape, and nature of a patient's damaged natural spinal discs. If one or more of the patient's vertebral bodies also require replacement, information about those bodies is also obtained. Thereafter, one or more prosthetic disc units and interposed prosthetic vertebral body units are constructed and preassembled in conformity with that information. Finally, the completed and conformed prosthetic disc and vertebral body assembly is implanted in the patient's spine.
 Other objects and advantages of the invention will become apparent upon reading the following detailed description and upon reference to the drawings. Throughout the drawings, like reference numerals refer to like parts.
FIG. 1 is a fragmentary vertical view of a portion of a human spine in which is installed a novel vertebral disc endoprosthesis embodying the present invention;
FIG. 2 is a fragmentary side elevational view similar to FIG. 1 showing the elements of a patient's spine and having a novel vertebral disc endoprosthesis embodying the present invention installed therein;
FIG. 3 is a sectional view taken substantially in the plane of line 3-3 in FIG. 1;
FIG. 4 is an exploded view of the novel vertebral disc endoprosthesis;
FIG. 5 is a vertical fragmentary view of a patient's spine similar to FIG. 1, but showing a series of novel disc endoprosthesis units installed in the spine and interconnected to one another;
FIG. 6 is a fragmentary sectional view of a patient's spine similar to FIG. 3 and taken along line 6-6 in FIG. 5, but showing a natural upper vertebral body, and upper endoprosthetic disc; an adjacent endoprosthetic vertebral body; a second or lower endoprosthetic disc; and a second or lower natural vertebral body; p FIG. 7 is a sectional view taken substantially in the plane of line 7-7 of FIG. 6;
FIG. 8 is a fragmentary side elevational view of the assembly shown in FIG. 6; and
FIG. 9 is a fragment vertical view, similar to FIG. 1, of a portion of a human spine in which is installed a variant form of the novel vertebral disc endoprosthesis the variant form having a prosthetic longitudinal ligament;
FIG. 10 is a sectional view taken substantially in the plane of line 10-10 in FIG. 9;
FIG. 11 is a top view of a retainer means for use with a vertebral disc endoprosthesis;
FIG. 12 is a sectional view taken substantially in the plane of line 12-12 of FIG. 11;
FIG. 13 is a side view of a vertebral disc endoprosthesis having a groove for receiving the retainer means; and
FIG. 14 is a cross-sectional view of the retainer means in use.
 While the invention will be described in connection with a preferred embodiment and procedure, it will be understood that it is not intended to limit the invention to this embodiment or procedure. On the contrary, it is intended to cover all alternatives, modifications, and equivalents as may be included within the spirit and scope of the invention as defined by the appended claims.
 Turning more specifically to FIGS. 1-3, a portion of a human spine 10 is shown. The illustrated spine 10 has been subjected to a discectomy surgical process. To discourage degeneration of or damage to the natural vertebral bodies 12 and 14 and their respective facet joints, in accordance with the invention, a vertebral disc endoprosthesis 18 is affixed between the adjacent natural vertebral bodies 12 and 14. Here this vertebral disc endoprosthesis 18 comprises a resilient disc body 20 having a relatively stiff annular gasket exterior portion 22 and a relatively supple nuclear central portion 24. The annular gasket 22 can be formed from a suitable biocompatible elastomer of approximately 90 durometer hardness and the nuclear central portion 24 can be formed from a softer biocompatible elastomeric polymer of approximately 30 durometer hardness.
 Concaval-convex means 30 surround the resilient body 20 to retain the resilient body 20 between the adjacent natural vertebral bodies 12, 14 in a patient's spine 10. To this end, as shown in FIG. 3, the concaval-convex means 30 comprise two generally L-shaped supports 32 and 34. The supports 32, 34 each have confronting first concaval-convex legs 42, 44, each leg being of relatively constant cross-sectional thickness. Each leg 42, 44 has an outer convex surface 52, 54 for engaging the adjacent bone of the natural vertebral bodies 12, 14. Corresponding inner concave surfaces 62, 64 in confronting array retain the resilient body 20 in its illustrated compressive force shock-absorbing position. These supports 32 and 34 can undergo principle movement away from one another, but only limited secondary translational, rotational and distractional motion will occur. Each support 32, 34 has a second wing or leg 72, 74 extending generally perpendicularly to the first legs 42, 44 respectively, and adapted for affixation to the adjacent bone structure. To carry out aspects of the invention described below, this affixation is effectively accomplished by cannulated screw devices 82, 84 which may be of a biodegradable type manufactured by Zimmer of Largo, Fla. Each device 82, 84 comprises a screw 92, 94; and a screw anchor 102, 104 adapted to threadably receive the screw extends radially into and seats within the bone structure 12, 14 as especially shown in FIG. 3.
 To discourage and prohibit migration of fluids between the endoprosthesis 18 and adjacent parts of the anatomy, a seal member 110 is attached to the supports 32, 34 so as to surround the resilient body 20 comprised of the gasket 22 and nucleus 24, in accordance with another aspect of the invention. Here, this seal member 110 comprises a flexible sheet material having a multiplicity of pores. Preferably, the pores are from about 5 microns to about 60 microns in size. A flexible, strong polymer sheet material from which this seal is formed can be a Kevlar-like material, or it can be Goretex-like material, or other appropriate biocompatible material, such as polyether, polyurethane, or polycarbonate urethane membranes, can be used. Kevlar material is offered by the E.I. DuPont de Nemours Company of Wilmington, Del. and Goretex material is offered by the W.T. Gore Company of Flagstaff and Phoenix, Ariz. Known sealing material can be applied to the flexible sheet material so as to render the flexible sheet material substantially impervious to the passage of any fluid. A watertight seal is perfected when the seal 110 is glued or otherwise affixed to the legs 42, 44 and mediate portions of the legs 72, 74 as suggested in FIGS. 1-3.
 In an alternative embodiment, the watertight seal between the endoprosthesis 18 and adjacent parts of the anatomy can be provided by developing a groove 402 completely encircling the periphery of each of the legs 42, 44. Only one of the grooves is shown in FIG. 13. In this embodiment, the seal member 410 is provided with a beaded edge 412 for each groove. Additionally, a retaining band 415 is provided for each groove to retain the seal member 410 in grooves 402. The retaining bands 415 can be in the form of a biocompatible monofilament wire of, for example, stainless steel or titanium, a synthetic polymer cable or a braided wire cable. As shown in FIG. 11, each retaining band is crimped anteriorly by a crimping sleeve 420. Of course, more than one crimping sleeve may be used, if necessary. Although one sealing arrangement consisting of the groove, beaded edge and retaining band is shown in FIG. 14, it should be understood that the sealing arrangement on the concaval-convex leg of the other support is identical in design and function.
 In use, the seal member 410 is placed about the concaval-convex means 30. The retaining bands 415 are then placed adjacent to the respective groove 402 and crimped anteriorly, thereby fitting the bands into the grooves. Each beaded edge 412 prevents the slipping of the seal member underneath the retaining band. Thus, the retaining band, the groove and the beaded edge all cooperate to provide a water-tight seal to prevent the migration of fluids between the endoprosthesis 18 and adjacent parts of the anatomy. Glue can also be used to affix the seal member to the concaval-convex means 30 as a supplemental means for perfecting the seal.
 In accordance with another aspect of the invention, the supports 32, 34 are formed of a biocompatible metal which may contain chromium cobalt or titanium. Surface roughening or titanium beading 112, 114 on the exterior surfaces 52, 54 of legs 42, 44 encourages positive bonding between the adjacent bone and the convex surfaces 52, 54.
 As suggested in FIGS. 9 and 10, a prosthetic longitudinal ligament 250 can be connected between the screws 92, 94 to limit motions between elements of the spine 10 in the area where the endoprosthesis 18 is implanted. This strap 250 may be made of the Kevlar-like material or the Goretex-like material described above, or it may be made of any other strong biocompatible material.
 In accordance with another aspect of the invention, multiple endoprosthetic disc units can be placed in series with a straddling interlock appendage providing stability and fixation as shown in FIG. 5. Entire portions of a patient's spine can be replaced by a series of interconnected endoprosthetic vertebral bodies and endoprosthetic disc units. FIGS. 6-8 show an upper natural vertebral body unit 312 to which an upper endoprosthetic body 308 has been attached. A lower natural vertebral body 314 has attached, at its upper end, an endoprosthetic disc unit 318. Between these endoprosthetic disc units 308 and 318 is an endoprosthetic vertebral body 320. As suggested by FIG. 7, the endoprosthetic vertebral body 320 need not be irregularly shaped in cross sectional aspect; rather, manufacturing processes may suggest that it have a circular cross-sectional shape. As show in FIGS. 6 and 8, this endoprosthetic vertebral body 320 comprises a titanium element 321, to which are attached the preformed upper and lower endoprosthetic vertebral body upper and lower concaval-convex elements 322, 324. Each concaval-convex element 322, 324 is attached to the prosthetic vertebral body 320, as shown in FIG. 7, by extending set screws 330 through the titanium vertebral body 321 into a stem-like projection 331 extending from each of the concaval-convex elements 322, 324. A hole 360 in the body 320 accommodates the stem-like projections 331 of the concaval-convex elements 322 and 324. The stem-like projection 331 of the concaval-convex elements 322 and 324 is used only in conjunction with a prosthetic vertebral body implant construction 320.
 An ear 340 is affixed, as by weldments 341, to a leg 342 extending from a concaval-convex element 322 as illustrated in FIGS. 6 and 8. An anchor 352 can be threaded into the endoprosthetic vertebral body 320, and a screw 362 can be turned into the anchor 352 so as to rigidly assemble the leg 342 to a leg 354 extending from the lower endoprosthetic disc unit 318.
 The upper disc endoprosthesis 308, the endoprosthetic vertebral body 320, and the lower disc endoprosthesis 318 can all be assembled and interconnected as a unit before implantation in a patient's body when indicated.
 As also suggested in FIG. 6, the annular corners 372, 374 of natural vertebral bodies 312, 314 each can extend irregularly radially outwardly of the adjacent disc endoprosthesis 308, 318. However, the corners 382B, 384B of the prosthetic vertebral body 320 do not generally extend significantly outside those disc units 308, 318, thus discouraging vertebral body engagement with and consequent abrasion or other damage to adjacent portions of the patient's natural anatomy. Preferably the endoprosthetic vertebral body 320 is not exactly right cylindrical in shape, but is rather slightly biconical; that is, the endoprosthetic vertebral body 320 has a waist 390 of minimum radius R at an axial medial point as suggested in FIG. 6.
 According to yet another aspect of the invention, novel surgical procedures permit effective and permanent installation of the endoprosthetic vertebral body 320 and associated parts. First, a surgeon or medical technician develops information about the size, shape and nature of a patient's damaged vertebral body or bodies from radiographs, CT and/or MRI scans, noting specifically the anterior-posterior and lateral dimensions of the end plate of each involved vertebral body and the vertical height of the anterior aspect of each involved vertebral and/or proximate vertebral body and vertical height of the mid portion of involved and proximate relatively normal intervertebral disc spaces. This information is transmitted by telephone, computer datalink or documentary transport to a specialized laboratory. That laboratory constructs one or more prosthetic assemblies of the sort shown in FIG. 6 in conformity with the received information and this disclosure. Each of the assemblies can include a prosthetic vertebral body 321, and at each body end is a prosthetic disc 308, 318. Each prosthetic disc unit comprises, in turn, the concaval-convex elements 30; the resilient body 20 interposed between the concaval-convex elements; and the seal unit 110 secured around the interior legs and resilient body. Thereafter, the completed and conformed assembly is implanted in the patient's spine 10.
 When the unit or units have been received and the patient properly prepared, the damaged natural spinal disc or discs and vertebral body or bodies are removed and the adjacent spinal bone surfaces are milled or otherwise formed to provide concave surfaces to receive the confronting convex surfaces 52, 54. Thereafter, the disc units and vertebral body are installed in the patient's spine.
 To accurately locate the concaval-convex surfaces in the patient's spine, holes 382A, 384A (FIG. 3) are precisely located and then formed in the bone structure using a measuring instrument centered in the evacuated natural intravertebral disc space. These holes are then tapped to form female threads therein. When the threads have been formed, the anchors 102, 104 are implanted in the respective tapped holes, thereby creating reference points located precisely with respect to the patient's spine. After the holes have been formed and the anchors 102, 104 implanted, a bone surface milling jig (not shown) is affixed to the anchors 102, 104 and the desired concave surfaces of predetermined shape are formed on the inferior and superior surfaces of the opposing vertebral bodies using one of a selection of predetermined milling head or bit sizes. Thereafter, the bone milling jig is removed and the concaval-convex elements 52, 54 identical in shape to the milled surfaces 112, 114 are inserted between the distracted milled vertebral bodies 12, 14. The distraction device is then moved. The concaval-convex structures are then attached by the same anchors 102, 104 to the bone, thus insuring a precise and stable mate between the bone surfaces and the convex surfaces 52, 54.
 If necessary, a damaged implanted nucleus and/or gasket 24 can be removed and replaced. This can be accomplished by slitting the seal 110; removing the annular gasket 24 and damaged nucleus 22, and replacing them with new, undamaged elements. Thereafter, the seal 110 can be re-established by suturing or gluing closed the slit seal.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2677369 *||Mar 26, 1952||May 4, 1954||Fred L Knowles||Apparatus for treatment of the spinal column|
|US3875595 *||Apr 15, 1974||Apr 8, 1975||Froning Edward C||Intervertebral disc prosthesis and instruments for locating same|
|US3876728 *||Mar 16, 1973||Apr 8, 1975||Hodogaya Chemical Co Ltd||Urethane resins from tolylene diisocyanate distillation residues active hydrogen containing compounds and vinyl monomers|
|US4023572 *||Aug 5, 1975||May 17, 1977||Hanfried Weigand||Milling tool for preparing a joint socket in the prosthetic replacement of a joint|
|US4116200 *||Oct 1, 1976||Sep 26, 1978||Aesculap-Werke Aktiengesellschaft Vormals Jetter & Scheerer||Milling tool for surgical purposes|
|US4309777 *||Nov 13, 1980||Jan 12, 1982||Patil Arun A||Artificial intervertebral disc|
|US4349921 *||Jun 16, 1980||Sep 21, 1982||Kuntz J David||Intervertebral disc prosthesis|
|US4599086 *||Jun 7, 1985||Jul 8, 1986||Doty James R||Spine stabilization device and method|
|US4645507 *||Sep 3, 1985||Feb 24, 1987||Gmt Gesellschaft Fur Medizinische Technik Mbh||Prosthesis|
|US4743256 *||Jan 22, 1987||May 10, 1988||Brantigan John W||Surgical prosthetic implant facilitating vertebral interbody fusion and method|
|US4757983 *||Aug 20, 1986||Jul 19, 1988||Charles D. Ray, Ltd.||Head and chin for face-down operations|
|US4759766 *||Sep 9, 1987||Jul 26, 1988||Humboldt-Universitaet Zu Berlin||Intervertebral disc endoprosthesis|
|US4759769 *||Jun 22, 1987||Jul 26, 1988||Health & Research Services Inc.||Artificial spinal disc|
|US4766328 *||May 26, 1987||Aug 23, 1988||System-General Corporation||Programmable pulse generator|
|US4777942 *||Sep 24, 1987||Oct 18, 1988||Sulzer Brothers Limited||Bone milling instrument|
|US4800639 *||Jun 12, 1987||Jan 31, 1989||Sulzer Brothers Limited||Method of making a metal bone implant|
|US4834757 *||Mar 28, 1988||May 30, 1989||Brantigan John W||Prosthetic implant|
|US4863476 *||Aug 28, 1987||Sep 5, 1989||Shepperd John A N||Spinal implant|
|US4863477 *||May 12, 1987||Sep 5, 1989||Monson Gary L||Synthetic intervertebral disc prosthesis|
|US4874389 *||Dec 7, 1987||Oct 17, 1989||Downey Ernest L||Replacement disc|
|US4904260 *||Jul 25, 1988||Feb 27, 1990||Cedar Surgical, Inc.||Prosthetic disc containing therapeutic material|
|US4904261 *||Aug 4, 1988||Feb 27, 1990||A. W. Showell (Surgicraft) Limited||Spinal implants|
|US4908032 *||Mar 2, 1988||Mar 13, 1990||Waldemar Link Gmbh & Co.||Reconstruction prosthesis|
|US4908036 *||May 31, 1988||Mar 13, 1990||Waldemar Link Gmbh & Co.||Endoprosthesis|
|US4911718 *||Jun 10, 1988||Mar 27, 1990||University Of Medicine & Dentistry Of N.J.||Functional and biocompatible intervertebral disc spacer|
|US4917704 *||Jun 8, 1988||Apr 17, 1990||Sulzer Brothers Limited||Intervertebral prosthesis|
|US4932969 *||Dec 17, 1987||Jun 12, 1990||Sulzer Brothers Limited||Joint endoprosthesis|
|US4932975 *||Oct 16, 1989||Jun 12, 1990||Vanderbilt University||Vertebral prosthesis|
|US4946378 *||Nov 22, 1988||Aug 7, 1990||Asahi Kogaku Kogyo Kabushiki Kaisha||Artificial intervertebral disc|
|US4955908 *||Jun 8, 1988||Sep 11, 1990||Sulzer Brothers Limited||Metallic intervertebral prosthesis|
|US4997432 *||Mar 14, 1989||Mar 5, 1991||Waldemar Link Gmbh & Co.||Surgical instrument set|
|US5002576 *||Jun 6, 1989||Mar 26, 1991||Mecron Medizinische Produkte Gmbh||Intervertebral disk endoprosthesis|
|US5015247 *||Jun 13, 1988||May 14, 1991||Michelson Gary K||Threaded spinal implant|
|US5035716 *||May 10, 1990||Jul 30, 1991||Downey Ernest L||Replacement disc|
|US5047055 *||Dec 21, 1990||Sep 10, 1991||Pfizer Hospital Products Group, Inc.||Hydrogel intervertebral disc nucleus|
|US5059193 *||Apr 19, 1990||Oct 22, 1991||Spine-Tech, Inc.||Expandable spinal implant and surgical method|
|US5059194 *||Feb 12, 1990||Oct 22, 1991||Michelson Gary K||Cervical distractor|
|US5080662 *||Nov 27, 1989||Jan 14, 1992||Paul Kamaljit S||Spinal stereotaxic device and method|
|US5084048 *||Jun 29, 1990||Jan 28, 1992||Sulzer Brothers Limited||Implant for vertebrae with spinal stabilizer|
|US5108438 *||May 7, 1990||Apr 28, 1992||Regen Corporation||Prosthetic intervertebral disc|
|US5122130 *||Oct 25, 1990||Jun 16, 1992||Waldemar Link Gmbh & Co.||Forceps for inserting intervertebral device|
|US5123926 *||Feb 22, 1991||Jun 23, 1992||Madhavan Pisharodi||Artificial spinal prosthesis|
|US5176708 *||Feb 28, 1991||Jan 5, 1993||Sulzer Brothers Limited||Prosthetic implant|
|US5192326 *||Sep 9, 1991||Mar 9, 1993||Pfizer Hospital Products Group, Inc.||Hydrogel bead intervertebral disc nucleus|
|US5192327 *||Mar 22, 1991||Mar 9, 1993||Brantigan John W||Surgical prosthetic implant for vertebrae|
|US5234431 *||Apr 2, 1992||Aug 10, 1993||Waldemar Link Gmbh & Co.||Bone plate arrangement|
|US5236460 *||Oct 10, 1991||Aug 17, 1993||Midas Rex Pneumatic Tools, Inc.||Vertebral body prosthesis|
|US5246458 *||Oct 7, 1992||Sep 21, 1993||Graham Donald V||Artificial disk|
|US5314478 *||Apr 26, 1991||May 24, 1994||Kyocera Corporation||Artificial bone connection prosthesis|
|US5320644 *||Jul 30, 1992||Jun 14, 1994||Sulzer Brothers Limited||Intervertebral disk prosthesis|
|US5383933 *||Nov 26, 1992||Jan 24, 1995||Waldemar Link Gmbh & Co.||Endoprosthesis|
|US5401269 *||Mar 10, 1993||Mar 28, 1995||Waldemar Link Gmbh & Co.||Intervertebral disc endoprosthesis|
|US5403314 *||Feb 5, 1993||Apr 4, 1995||Acromed Corporation||Apparatus for retaining spinal elements in a desired spatial relationship|
|US5425772 *||Sep 20, 1993||Jun 20, 1995||Brantigan; John W.||Prosthetic implant for intervertebral spinal fusion|
|US5425773 *||Apr 5, 1994||Jun 20, 1995||Danek Medical, Inc.||Intervertebral disk arthroplasty device|
|US5443514 *||Oct 1, 1993||Aug 22, 1995||Acromed Corporation||Method for using spinal implants|
|US5456719 *||Sep 18, 1992||Oct 10, 1995||Waldemar Link Gmbh & Co||Endoprosthesis with a prosthesis part made of viscoelastic synthetic resin|
|US5458638 *||Nov 6, 1992||Oct 17, 1995||Spine-Tech, Inc.||Non-threaded spinal implant|
|US5458642 *||Jan 18, 1994||Oct 17, 1995||Beer; John C.||Synthetic intervertebral disc|
|US5484437 *||Jun 10, 1993||Jan 16, 1996||Michelson; Gary K.||Apparatus and method of inserting spinal implants|
|US5487307 *||Feb 10, 1994||Jan 30, 1996||Kalman Floor Company, Inc.||Method and apparatus for testing concrete expansion|
|US5489308 *||Sep 1, 1994||Feb 6, 1996||Spine-Tech, Inc.||Spinal implant|
|US5496318 *||Aug 18, 1993||Mar 5, 1996||Advanced Spine Fixation Systems, Inc.||Interspinous segmental spine fixation device|
|US5507816 *||Dec 1, 1992||Apr 16, 1996||Customflex Limited||Spinal vertebrae implants|
|US5514180 *||Jan 14, 1994||May 7, 1996||Heggeness; Michael H.||Prosthetic intervertebral devices|
|US5527315 *||Oct 18, 1994||Jun 18, 1996||Jbs S.A.||Spinal osteosynthesis rod with three branches|
|US5534028 *||Apr 20, 1993||Jul 9, 1996||Howmedica, Inc.||Hydrogel intervertebral disc nucleus with diminished lateral bulging|
|US5534029 *||Dec 1, 1993||Jul 9, 1996||Yumiko Shima||Articulated vertebral body spacer|
|US5534090 *||Dec 20, 1984||Jul 9, 1996||The United States Of America As Represented By The Secretary Of The Air Force||Dosimeter capsule indicating service life of a rocket motor|
|US5545229 *||Jul 28, 1993||Aug 13, 1996||University Of Medicine And Dentistry Of Nj||Functional and biocompatible intervertebral disc spacer containing elastomeric material of varying hardness|
|US5549679 *||Mar 1, 1995||Aug 27, 1996||Kuslich; Stephen D.||Expandable fabric implant for stabilizing the spinal motion segment|
|US5556431 *||Aug 9, 1994||Sep 17, 1996||B+E,Uml U+Ee Ttner-Janz; Karin||Intervertebral disc endoprosthesis|
|US5562738 *||Jan 12, 1995||Oct 8, 1996||Danek Medical, Inc.||Intervertebral disk arthroplasty device|
|US5593409 *||Feb 17, 1995||Jan 14, 1997||Sofamor Danek Group, Inc.||Interbody spinal fusion implants|
|US5645598 *||Apr 15, 1996||Jul 8, 1997||Smith & Nephew, Inc.||Spinal fusion device with porous material|
|US5720748 *||Jun 7, 1995||Feb 24, 1998||Spine-Tech, Inc.||Spinal stabilization surgical apparatus|
|US5722977 *||Jan 24, 1996||Mar 3, 1998||Danek Medical, Inc.||Method and means for anterior lumbar exact cut with quadrilateral osteotome and precision guide/spacer|
|US5741253 *||Oct 29, 1992||Apr 21, 1998||Michelson; Gary Karlin||Method for inserting spinal implants|
|US5782830 *||Jul 10, 1996||Jul 21, 1998||Sdgi Holdings, Inc.||Implant insertion device|
|US5782832 *||Oct 1, 1996||Jul 21, 1998||Surgical Dynamics, Inc.||Spinal fusion implant and method of insertion thereof|
|US5797909 *||Jun 7, 1995||Aug 25, 1998||Michelson; Gary Karlin||Apparatus for inserting spinal implants|
|US5865848 *||Sep 12, 1997||Feb 2, 1999||Artifex, Ltd.||Dynamic intervertebral spacer and method of use|
|US5885300 *||Mar 31, 1997||Mar 23, 1999||Asahi Kogaku Kogyo Kabushiki Kaisha||Guide apparatus of intervertebral implant|
|US5888226 *||Nov 12, 1997||Mar 30, 1999||Rogozinski; Chaim||Intervertebral prosthetic disc|
|US5928284 *||Jul 9, 1998||Jul 27, 1999||Mehdizadeh; Hamid M.||Disc replacement prosthesis|
|US5947971 *||Nov 21, 1996||Sep 7, 1999||Sulzer Spine-Tech Inc.||Spinal stabilization surgical apparatus|
|US6022376 *||Mar 16, 1998||Feb 8, 2000||Raymedica, Inc.||Percutaneous prosthetic spinal disc nucleus and method of manufacture|
|US6059790 *||Jul 16, 1998||May 9, 2000||Sulzer Spine-Tech Inc.||Apparatus and method for spinal stabilization|
|US6059829 *||Mar 8, 1995||May 9, 2000||Synthese||Intervertebral implant|
|US6063121 *||Jul 29, 1998||May 16, 2000||Xavier; Ravi||Vertebral body prosthesis|
|US6066174 *||Jul 17, 1998||May 23, 2000||Sdgi Holdings, Inc.||Implant insertion device|
|US6080155 *||Feb 27, 1995||Jun 27, 2000||Michelson; Gary Karlin||Method of inserting and preloading spinal implants|
|US6083228 *||Jun 9, 1998||Jul 4, 2000||Michelson; Gary K.||Device and method for preparing a space between adjacent vertebrae to receive an insert|
|US6086595 *||Aug 29, 1997||Jul 11, 2000||Sulzer Spine-Tech Inc.||Apparatus and method for spinal stabilization|
|US6096038 *||Jun 7, 1995||Aug 1, 2000||Michelson; Gary Karlin||Apparatus for inserting spinal implants|
|US6179874 *||Apr 23, 1999||Jan 30, 2001||Cauthen Research Group, Inc.||Articulating spinal implant|
|US6228022 *||Oct 28, 1998||May 8, 2001||Sdgi Holdings, Inc.||Methods and instruments for spinal surgery|
|US6228026 *||Aug 13, 1999||May 8, 2001||Rultract, Inc.||Surgical support apparatus with splined coupling, cross bar support and head-to-toe extension for surgical retractor apparatus|
|US6231609 *||Feb 10, 1999||May 15, 2001||Hamid M. Mehdizadeh||Disc replacement prosthesis|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US6960232||Apr 25, 2003||Nov 1, 2005||Blackstone Medical, Inc.||Artificial intervertebral disc|
|US7338525 *||Apr 30, 2003||Mar 4, 2008||Ferree Bret A||Methods and apparatus for preventing the migration of intradiscal devices|
|US7556651 *||Jan 7, 2005||Jul 7, 2009||Warsaw Orthopedic, Inc.||Posterior spinal device and method|
|US7655045||Jul 27, 2006||Feb 2, 2010||Aesculap Implant Systems, Llc||Artificial intervertebral disc|
|US7666226||Aug 15, 2006||Feb 23, 2010||Benvenue Medical, Inc.||Spinal tissue distraction devices|
|US7666227||Aug 15, 2006||Feb 23, 2010||Benvenue Medical, Inc.||Devices for limiting the movement of material introduced between layers of spinal tissue|
|US7670374||Aug 15, 2006||Mar 2, 2010||Benvenue Medical, Inc.||Methods of distracting tissue layers of the human spine|
|US7670375||Aug 15, 2006||Mar 2, 2010||Benvenue Medical, Inc.||Methods for limiting the movement of material introduced between layers of spinal tissue|
|US7731754||Aug 30, 2006||Jun 8, 2010||Spinalmotion, Inc.||Intervertebral prosthesis|
|US7753941||Sep 17, 2004||Jul 13, 2010||Anulex Technologies, Inc.||Devices and methods for annular repair of intervertebral discs|
|US7758649 *||Aug 4, 2006||Jul 20, 2010||Integrity Intellect Inc.||Reversibly deformable implant|
|US7763075||Feb 24, 2006||Jul 27, 2010||Theken Spine, Llc||Artificial disc prosthesis|
|US7763076||Feb 24, 2006||Jul 27, 2010||Theken Spine, Llc||Artificial disc prosthesis|
|US7766966||Jul 27, 2006||Aug 3, 2010||Aesculap Implant Systems, Llc||Artificial intervertebral disc|
|US7771478||Apr 2, 2004||Aug 10, 2010||Theken Spine, Llc||Artificial disc prosthesis|
|US7771480||Feb 24, 2006||Aug 10, 2010||Theken Spine, Llc||Artificial disc prosthesis|
|US7785368||Aug 15, 2006||Aug 31, 2010||Benvenue Medical, Inc.||Spinal tissue distraction devices|
|US7803189 *||Sep 29, 2006||Sep 28, 2010||Spinal Kinetics, Inc.||Prosthetic facet and facet joint replacement device|
|US7806935||Feb 24, 2006||Oct 5, 2010||Theken Spine, Llc||Artificial disc prosthesis|
|US7811326||Jan 30, 2006||Oct 12, 2010||Warsaw Orthopedic Inc.||Posterior joint replacement device|
|US7832409||Oct 19, 2007||Nov 16, 2010||Aesculap Implant Systems, Llc||Method of inserting an artificial intervertebral disc|
|US7905922||Dec 20, 2006||Mar 15, 2011||Zimmer Spine, Inc.||Surgical implant suitable for replacement of an intervertebral disc|
|US7905923||May 25, 2007||Mar 15, 2011||Anulex Technologies, Inc.||Devices and methods for annular repair of intervertebral discs|
|US7927374||Nov 13, 2006||Apr 19, 2011||Synergy Disc Replacement, Inc.||Artificial spinal disc|
|US7955391||Feb 15, 2010||Jun 7, 2011||Benvenue Medical, Inc.||Methods for limiting the movement of material introduced between layers of spinal tissue|
|US7963993||Feb 15, 2010||Jun 21, 2011||Benvenue Medical, Inc.||Methods of distracting tissue layers of the human spine|
|US7967864||Feb 15, 2010||Jun 28, 2011||Benvenue Medical, Inc.||Spinal tissue distraction devices|
|US7967865||Feb 15, 2010||Jun 28, 2011||Benvenue Medical, Inc.||Devices for limiting the movement of material introduced between layers of spinal tissue|
|US8002834||Apr 28, 2009||Aug 23, 2011||Spinalmotion, Inc.||Intervertebral prosthetic disc with metallic core|
|US8029569 *||Oct 4, 2011||International Spinal Innovations, Llc||Implantable spinal disk|
|US8057544||Aug 15, 2006||Nov 15, 2011||Benvenue Medical, Inc.||Methods of distracting tissue layers of the human spine|
|US8062371||Nov 22, 2011||Spinalmotion, Inc.||Intervertebral prosthetic disc with metallic core|
|US8083797||Feb 4, 2005||Dec 27, 2011||Spinalmotion, Inc.||Intervertebral prosthetic disc with shock absorption|
|US8090428||Nov 11, 2009||Jan 3, 2012||Spinalmotion, Inc.||Spinal midline indicator|
|US8092538||Apr 15, 2008||Jan 10, 2012||Spinalmotion, Inc.||Intervertebral prosthetic disc|
|US8100974||Jun 30, 2005||Jan 24, 2012||Synergy Disc Replacement, Inc.||Artificial spinal disc|
|US8172904||Sep 21, 2006||May 8, 2012||Synergy Disc Replacement, Inc.||Artificial spinal disc|
|US8206447||Mar 7, 2008||Jun 26, 2012||Spinalmotion, Inc.||Methods and apparatus for intervertebral disc prosthesis insertion|
|US8206449||Jul 16, 2009||Jun 26, 2012||Spinalmotion, Inc.||Artificial intervertebral disc placement system|
|US8262732||May 30, 2008||Sep 11, 2012||Spinalmotion, Inc.||Intervertebral prosthesis|
|US8262735||Jul 21, 2011||Sep 11, 2012||International Spinal Innovations, Llc||Implantable spinal disk|
|US8366773||Jan 25, 2008||Feb 5, 2013||Benvenue Medical, Inc.||Apparatus and method for treating bone|
|US8372150||Aug 2, 2010||Feb 12, 2013||Warsaw Orthpedic, Inc.||Spinal device and method|
|US8398712||Nov 9, 2011||Mar 19, 2013||Spinalmotion, Inc.||Intervertebral prosthetic disc with shock absorption|
|US8409287 *||May 21, 2010||Apr 2, 2013||Warsaw Orthopedic, Inc.||Intervertebral prosthetic systems, devices, and associated methods|
|US8444695||May 12, 2009||May 21, 2013||Spinalmotion, Inc.||Prosthetic disc for intervertebral insertion|
|US8454617||Jun 4, 2013||Benvenue Medical, Inc.||Devices for treating the spine|
|US8454698||Feb 13, 2008||Jun 4, 2013||Spinalmotion, Inc.||Prosthetic disc for intervertebral insertion|
|US8486147||Feb 4, 2008||Jul 16, 2013||Spinalmotion, Inc.||Posterior spinal device and method|
|US8506631||Sep 15, 2010||Aug 13, 2013||Spinalmotion, Inc.||Customized intervertebral prosthetic disc with shock absorption|
|US8535327||Mar 16, 2010||Sep 17, 2013||Benvenue Medical, Inc.||Delivery apparatus for use with implantable medical devices|
|US8556978||Nov 15, 2011||Oct 15, 2013||Benvenue Medical, Inc.||Devices and methods for treating the vertebral body|
|US8591583||Feb 21, 2008||Nov 26, 2013||Benvenue Medical, Inc.||Devices for treating the spine|
|US8636805||May 21, 2012||Jan 28, 2014||Spinalmotion, Inc.||Artificial intervertebral disc placement system|
|US8685035||Jul 21, 2005||Apr 1, 2014||Spinalmotion, Inc.||Intervertebral prosthesis placement instrument|
|US8696749||Jul 15, 2004||Apr 15, 2014||Blackstone Medical, Inc.||Artificial intervertebral disc|
|US8734519||Apr 12, 2007||May 27, 2014||Spinalmotion, Inc.||Posterior spinal device and method|
|US8758441||Oct 22, 2008||Jun 24, 2014||Spinalmotion, Inc.||Vertebral body replacement and method for spanning a space formed upon removal of a vertebral body|
|US8764833||Mar 9, 2009||Jul 1, 2014||Spinalmotion, Inc.||Artificial intervertebral disc with lower height|
|US8771356||Sep 14, 2012||Jul 8, 2014||Spinalmotion, Inc.||Intervertebral prosthetic disc|
|US8795375||Jul 23, 2009||Aug 5, 2014||Resspond Spinal Systems||Modular nucleus pulposus prosthesis|
|US8801787||Jun 16, 2011||Aug 12, 2014||Benvenue Medical, Inc.||Methods of distracting tissue layers of the human spine|
|US8801792||Jul 22, 2010||Aug 12, 2014||Spinalmotion, Inc.||Posterio spinal device and method|
|US8808376||Mar 25, 2009||Aug 19, 2014||Benvenue Medical, Inc.||Intravertebral implants|
|US8845729||Nov 25, 2009||Sep 30, 2014||Simplify Medical, Inc.||Prosthetic disc for intervertebral insertion|
|US8845730||Jul 16, 2009||Sep 30, 2014||Simplify Medical, Inc.||Posterior prosthetic intervertebral disc|
|US8864832||Aug 16, 2007||Oct 21, 2014||Hh Spinal Llc||Posterior total joint replacement|
|US8882836||Dec 18, 2012||Nov 11, 2014||Benvenue Medical, Inc.||Apparatus and method for treating bone|
|US8888852||Jun 15, 2009||Nov 18, 2014||Hh Spinal Llc||Spinal athroplasty device and method|
|US8961609||Sep 26, 2013||Feb 24, 2015||Benvenue Medical, Inc.||Devices for distracting tissue layers of the human spine|
|US8968408||Apr 24, 2013||Mar 3, 2015||Benvenue Medical, Inc.||Devices for treating the spine|
|US8974531||Dec 30, 2009||Mar 10, 2015||Simplify Medical, Inc.||Methods and apparatus for intervertebral disc prosthesis insertion|
|US8974533||Jan 8, 2014||Mar 10, 2015||Simplify Medical, Inc.||Prosthetic disc for intervertebral insertion|
|US8979929||Jun 16, 2011||Mar 17, 2015||Benvenue Medical, Inc.||Spinal tissue distraction devices|
|US9011544||Aug 17, 2010||Apr 21, 2015||Simplify Medical, Inc.||Polyaryletherketone artificial intervertebral disc|
|US9034038||Apr 7, 2009||May 19, 2015||Spinalmotion, Inc.||Motion limiting insert for an artificial intervertebral disc|
|US9044336||May 29, 2012||Jun 2, 2015||International Spinal Innovations, Llc||Implantable spinal disk|
|US9044338||Mar 12, 2013||Jun 2, 2015||Benvenue Medical, Inc.||Spinal tissue distraction devices|
|US9066808||Feb 20, 2009||Jun 30, 2015||Benvenue Medical, Inc.||Method of interdigitating flowable material with bone tissue|
|US9066809 *||May 15, 2009||Jun 30, 2015||Globus Medical Inc.||Method for inserting and positioning an artificial disc|
|US9107762||Nov 3, 2011||Aug 18, 2015||Spinalmotion, Inc.||Intervertebral prosthetic disc with metallic core|
|US20040267369 *||Jul 15, 2004||Dec 30, 2004||Matthew Lyons||Artificial intervertebral disc|
|US20050033438 *||Jun 29, 2004||Feb 10, 2005||Robert Schultz||Intervertebral implant|
|US20050043803 *||Jul 6, 2004||Feb 24, 2005||Robert Schultz||Intervertebral implant|
|US20050060036 *||Jul 6, 2004||Mar 17, 2005||Robert Schultz||Spinal column implant|
|US20050080487 *||Jun 29, 2004||Apr 14, 2005||Robert Schultz||Intervertebral implant|
|US20050143824 *||Jun 15, 2004||Jun 30, 2005||Marc Richelsoph||Artificial intervertebral disc|
|US20050154466 *||Jan 7, 2005||Jul 14, 2005||Sdgi Holdings, Inc.||Posterior spinal device and method|
|US20060009541 *||Jul 9, 2004||Jan 12, 2006||Yih-Fang Chen||Saturant for friction material containing friction modifying layer|
|US20060030857 *||Aug 6, 2004||Feb 9, 2006||Spinalmotion, Inc.||Methods and apparatus for intervertebral disc prosthesis insertion|
|US20060142860 *||Feb 24, 2006||Jun 29, 2006||Theken Disc, Llc||Artificial disc prosthesis|
|US20060149377 *||Feb 24, 2006||Jul 6, 2006||Theken Disc, Llc||Artificial disc prosthesis|
|US20060235523 *||Apr 19, 2005||Oct 19, 2006||Sdgi Holdings, Inc.||Implant having a sheath with a motion-limiting attribute|
|US20060235525 *||Apr 19, 2005||Oct 19, 2006||Sdgi Holdings, Inc.||Composite structure for biomedical implants|
|US20060259146 *||Feb 24, 2006||Nov 16, 2006||Theken Disc, Llc||Artificial disc prosthesis|
|US20060265071 *||Jul 27, 2006||Nov 23, 2006||Marc Richelsoph||Artificial intervertebral disc|
|US20060265072 *||Jul 27, 2006||Nov 23, 2006||Marc Richelsoph||Artificial intervertebral disc|
|US20070016190 *||Jul 14, 2005||Jan 18, 2007||Medical Device Concepts Llc||Dynamic spinal stabilization system|
|US20070016204 *||Jul 14, 2005||Jan 18, 2007||Medical Device Concepts Llc.||Spinal buttress device and method|
|US20100292799 *||May 15, 2009||Nov 18, 2010||Noah Hansell||Method for Inserting and Positioning an Artificial Disc|
|US20110288645 *||May 21, 2010||Nov 24, 2011||Warsaw Orthopedic, Inc.||Intervertebral prosthetic systems, devices, and associated methods|
|US20110313556 *||Dec 22, 2011||Sten Holm||Method and arrangement at implants preferably for a human intervertebral and such implant|
|EP2327376A2||Jun 30, 2005||Jun 1, 2011||Synergy Disc Replacement Inc.||Artificial spinal disc|
|EP2641571A1||Jun 30, 2005||Sep 25, 2013||Synergy Disc Replacement Inc.||Artificial spinal disc|
|WO2008103781A2 *||Feb 21, 2008||Aug 28, 2008||Benvenue Medical Inc||Devices for treating the spine|
|WO2010011849A1 *||Jul 23, 2009||Jan 28, 2010||Malberg Marc I||Modular nucleus pulposus prosthesis|
|U.S. Classification||623/17.15, 623/17.16|
|International Classification||A61B17/70, A61F2/44, A61F2/08, A61B17/00, A61B17/86, A61F2/30, A61F2/00, A61B17/68|
|Cooperative Classification||Y10S606/91, Y10S606/907, A61F2002/30772, A61F2/30771, A61F2230/0006, A61F2002/30168, A61F2002/449, A61F2230/0069, A61F2002/30253, A61F2002/30069, A61F2002/30578, A61F2250/0019, A61F2002/30464, A61F2002/30507, A61F2002/30461, A61F2002/30663, A61F2002/30487, A61F2220/0041, A61F2002/30474, A61F2230/0065, A61F2002/30113, A61F2220/005, A61F2002/30433, A61B17/7059, A61F2230/0076, A61F2002/30563, A61F2002/30624, A61F2002/30214, A61F2002/443, A61F2002/30594, A61F2002/30016, A61F2220/0075, A61B2017/00004, A61F2220/0033, A61F2002/30599, A61F2310/00023, A61F2230/0067, A61F2002/30451, A61F2/44, A61F2220/0058, A61F2220/0025, A61F2/30742, A61F2230/0043, A61F2002/30579, A61F2002/30576, A61F2002/30405, A61F2/4425, A61F2002/30469, A61F2002/302, A61B17/686, A61B17/86, A61F2002/30495, A61F2002/30235, A61F2/08, A61F2310/00029, A61F2250/0063, A61F2002/30448, A61F2002/30785, A61F2002/3038, A61F2/442|
|European Classification||A61B17/68P, A61F2/30B8, A61F2/44D, A61F2/44D2, A61F2/44|