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Publication numberUS20040126461 A1
Publication typeApplication
Application numberUS 10/692,178
Publication dateJul 1, 2004
Filing dateOct 23, 2003
Priority dateOct 23, 2002
Also published asCA2503363A1, CA2503363C, CA2503373A1, CA2503373C, DE60325265D1, DE60336336D1, EP1562447A1, EP1562447A4, EP1562447B1, EP1562449A1, EP1562449A4, EP1562449B1
Publication number10692178, 692178, US 2004/0126461 A1, US 2004/126461 A1, US 20040126461 A1, US 20040126461A1, US 2004126461 A1, US 2004126461A1, US-A1-20040126461, US-A1-2004126461, US2004/0126461A1, US2004/126461A1, US20040126461 A1, US20040126461A1, US2004126461 A1, US2004126461A1
InventorsThomas Lines, Mitsunori Ono
Original AssigneeLines Thomas Christian, Mitsunori Ono
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Composition for enhancing physical performance
US 20040126461 A1
Abstract
A composition that contains (1) quercetin and vitamin B3, or (2) quercetin and vitamin C. Also disclosed is a method of using the composition for enhancing physical performance.
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Claims(29)
What is claimed is:
1. A composition comprising vitamin B3 and quercetin.
2. A composition comprising vitamin C and quercetin.
3. The composition of claim 2, further comprising vitamin B3.
4. The composition of claim 3, further comprising at least one of vitamin B 1, vitamin B2, vitamin B6, vitamin B12, and vitamin E.
5. The composition of claim 4, further comprising at least one of caffeine, epigallocatechin gallate, epicatechin, epicatechin gallate, epigallocatechin, and polypheron E.
6. The composition of claim 4, further comprising a green tea extract containing at least one of caffeine, epigallocatechin gallate, epicatechin, epicatechin gallate, epigallocatechin, and polypheron E.
7. The composition of claim 1, wherein the composition is in dry form.
8. The composition of claim 2, wherein the composition is in dry form.
9. The composition of claim 3, wherein the composition is in dry form.
10. The composition of claim 1, wherein the composition is tea, soft drinks, juice, milk, coffee, jelly, ice cream, yogurt, cookies, cereals, chocolates, or snack bars.
11. The composition of claim 2, wherein the composition is tea, soft drinks, juice, milk, coffee, jelly, ice cream, yogurt, cookies, cereals, chocolates, or snack bars.
12. The composition of claim 3, wherein the composition is tea, soft drinks, juice, milk, coffee, jelly, ice cream, yogurt, cookies, cereals, chocolates, or snack bars.
13. The composition of claim 4, wherein the composition is tea, soft drinks, juice, milk, coffee, jelly, ice cream, yogurt, cookies, cereals, chocolates, or snack bars.
14. The composition of claim 5, wherein the composition is tea, soft drinks, juice, milk, coffee, jelly, ice cream, yogurt, cookies, cereals, chocolates, or snack bars.
15. The composition of claim 6, wherein the composition is tea, soft drinks, juice, milk, coffee, jelly, ice cream, yogurt, cookies, cereals, chocolates, or snack bars.
16. The composition of claim 1, further comprising at least one of CoQ-10, soy isoflavones, taurine, sugar beet pectin fiber, and a ginko biloba extract.
17. The composition of claim 2, further comprising at least one of CoQ-10, soy isoflavones, taurine, sugar beet pectin fiber, and a ginko biloba extract.
18. The composition of claim 3, further comprising at least one of CoQ-10, soy isoflavones, taurine, sugar beet pectin fiber, and a ginko biloba extract.
19. The composition of claim 4, further comprising at least one of CoQ-10, soy isoflavones, taurine, sugar beet pectin fiber, and a ginko biloba extract.
20. The composition of claim 5, further comprising at least one of CoQ-10, soy isoflavones, taurine, sugar beet pectin fiber, and a ginko biloba extract.
21. The composition of claim 6, further comprising at least one of CoQ-10, soy isoflavones, taurine, sugar beet pectin fiber, and a ginko biloba extract.
22. A method for enhancing physical performance, the method comprising administering to a subject in need thereof an effective amount of the composition of claim 1.
23. A method for enhancing physical performance, the method comprising administering to a subject in need thereof an effective amount of the composition of claim 2.
24. The method of claim 23, wherein the composition further comprises vitamin B3.
25. The method of claim 24, wherein the composition further comprises at least one of vitamin B1, vitamin B2, vitamin B6, vitamin B12, and vitamin E.
26. The method of claim 25, wherein the composition further comprises at least one of caffeine, epigallocatechin gallate, epicatechin, epicatechin gallate, epigallocatechin, and polypheron E.
27. The method of claim 25, wherein the composition further comprises at least one of a green tea extract containing caffeine, epigallocatechin gallate, epicatechin, epicatechin gallate, epigallocatechin, and polypheron E.
28. The method of claim 25, wherein the composition comprises vitamin B1, vitamin B2, vitamin B6, vitamin B12, and vitamin E.
29. The method of claim 26, wherein the composition comprises caffeine, epigallocatechin gallate, epicatechin, epicatechin gallate, epigallocatechin, and polypheron E.
Description
CROSS REFERENCE TO RELATED APPLICATION

[0001] This application is a continuation-in-part of U.S. application Ser. No. 10/302,544, filed Nov. 22, 2002. This application also claims priority to U.S. Application Serial No. 60/420,986, filed Oct. 23, 2002.

BACKGROUND

[0002] Achieving peak physical performance has long been a goal for athletic competition and self-improvement. Means for improving physical performance includes prolonged systematic exercise, proper diet, and use of pharmaceuticals such as anabolic steroids. Anabolic steroids, which are testosterone derivatives, promote tissue growth, increase muscle mass, increase blood volume and hemoglobin level, and improve overall strength. Nonetheless, the use of anabolic steroids often results in serious complications, such as decreased blood high-density lipoprotein levels, disorders of the reproductive system, and disorders of the liver including carcinoma and peliosis hepatis. These complications further lead to virilization in females, interrupted growth in children, and defects in fetuses. The use of anabolic steroid can also cause psychological disorders such as unpredictable mood changes and aggression. Thus, there is a need for a safe drug or dietary supplement for enhancing physical performance.

SUMMARY

[0003] This invention relates to a composition that contains quercetin and a number of other natural products. The composition can be used in enhancing physical performance, i.e., improving an ability to perform an exercise, such as speed, strength, power, endurance, flexibility, agility, balance, focus coordination, reaction time, and fatigue recovery.

[0004] One aspect of this invention features a composition that contains quercetin and one or both of vitamin B3 and vitamin C. In one embodiment, the composition further contains at least one of the following ingredients: vitamin B1, vitamin B2, vitamin B6, and vitamin B12. In another embodiment, it further contains at least one of caffeine, epigallocatechin gallate, epicatechin, epicatechin gallate, epigallocatechin, and polypheron E. This composition may also contain other ingredients, such as vitamin E, CoQ-10, soy isoflavones, taurine, sugar beet pectin fiber, and a ginko biloba extract. Further, the composition can be sweetened, if necessary, by adding a sweetener, e.g., sorbitol, maltitol, cane sugar, high fructose corn syrup, and the like. The composition can also contain amino acids, minerals, a flavor enhancer, or a coloring agent. It is known that the leaves of green tea contain epigallocatechin gallate, epicatechin, epicatechin gallate, epigallocatechin, and polypheron E. Thus, these five ingredients can be conveniently provided as a green tea extract.

[0005] The composition of the invention can be in dry form (e.g., powder or tablet) or in aqueous form (e.g., beverage or syrup). It can be a dietary supplement or a pharmaceutical formulation. It can also be a drink or a food product. Examples include tea (e.g., a tea drink and the contents of a tea bag), soft drinks, juice (e.g., a fruit extract and a juice drink), milk, coffee, jelly, ice cream, yogurt, cookies, cereals, chocolates, and snack bars. The composition, in any of the forms described above, can be used to enhance physical performance. Also within the scope of this invention is a composition of the invention as an active agent, as well as use of the composition for the manufacture of a medicament, for enhancing physical performance.

[0006] The invention also features a method for enhancing physical performance. The method includes administering to a subject in need thereof an effective amount of the above-described composition. By proper administrating the composition as detailed below, physical performance can be enhanced without the deleterious side effects of pharmaceutical performance enhancers, such as anabolic steroids.

[0007] The details of one or more embodiments of the invention are set forth in the accompanying description below. Other features, objects, and advantages of the invention will be apparent from the description and from the claims.

DETAILED DESCRIPTION

[0008] This invention is based, at least in part, on the unexpected discovery that quercetin, an antioxidant, and a number of other natural products exhibit synergistic health benefits, including enhancing physical performance in a subject.

[0009] For example, within the scope of this invention is a quercetin-containing composition that includes vitamin B3 or vitamin C, or both. It further contains one or more of vitamin B1, vitamin B2, vitamin B6, and vitamin B12. The composition can also contain one or more of caffeine, epigallocatechin gallate, epicatechin, epicatechin gallate, epigallocatechin, and polypheron E. A green tea extract can be conveniently used to provide epigallocatechin gallate, epicatechin, epicatechin gallate, epigallocatechin, and polypheron E.

[0010] Exemplary quantities of the ingredients of this composition are: 0.1-50 mg of vitamin B 1, 0.1-150 mg of vitamin B2, 0.1-2000 mg of vitamin B3, 0.1-200 mg of vitamin B6, 5-150 μg of vitamin B12, 50-2000 mg of vitamin C, 50-1500 mg of caffeine, 20-2000 mg of quercetin, 10-500 mg of epigallocatechin gallate, 10-500 mg of epicatechin, 10-500 mg of epicatechin gallate, 10-500 mg of epigallocatechin, and 10-500 mg of polypheron E, which can be dissolved or dispersed in a 1 L aqueous solution. The quantities of the ingredients can also be those of the same relative ratio to those listed above. The term “quercetin” refers to both quercetin aglycon and quercetin derivatives, e.g., quercetin-3-O-glucoside, quercetin-5-O-glucoside, quercetin-7-O-glucoside, quercetin-9-O-glucoside, quercetin-3-O-rutinoside, quercetin-3-0-[α-rhamnosyl-(1→2)-α-rhamnosyl-(1→6)]-β-glucoside, quercetin-3-O-galactoside, quercetin-7-O-galactoside, quercetin-3-O-rhamnoside, and quercetin-7-O-galactoside. After digestion, quercetin derivatives are converted to quercetin aglycon, an active form absorbed in the body. The quantity of quercetin mentioned above refers to that of quercetin aglycon or the quercetin moiety of a quercetin derivative. As an example, a composition for daily use can be a 1 L aqueous solution containing 1000 mg of quercetin, 30 mg of vitamin B1, 85 mg of vitamin B2, 1 g of vitamin B3, 100 mg of vitamin B6, 120 μg of vitamin B112, 1200 mg of vitamin C, 1000 IU of vitamin E, 1000 mg of caffeine, and a green tea extract containing 120 mg of epigallocatechin gallate, 140 mg of epicatechin, 360 mg of epicatechin gallate, 360 mg of epigallocatechin, and 120 mg of polypheron E.

[0011] This composition may also contain one or more other active ingredients, such as vitamin E, CoQ-10, soy isoflavones, taurine, sugar beet pectin fiber, and a ginko biloba extract. Exemplary quantities of these ingredients are: 3-1000 IU of vitamin E, 10-400 mg of CoQ-10, 20-600 mg of soy isoflavones, 10-1000 mg of taurine, 1-15 g of sugar beet pectin fiber, and 50-500 mg of a ginko biloba extract (dry weight). Further, the composition can be sweetened, if necessary, by adding a sweetener such as sorbitol, maltitol, hydrogenated glucose syrup and hydrogenated starch hydrolyzate, high fructose corn syrup, cane sugar, beet sugar, pectin, and sucralose.

[0012] An example of the above-described composition is a powder. It can be used conveniently to prepare beverages, e.g., tea or juice. The powder can also be used to prepare paste, jelly, capsules, or tablets. Lactose and corn starch are commonly used as diluents for capsules and as carriers for tablets. Lubricating agents, such as magnesium stearate, are typically added to form tablets.

[0013] The composition of this invention can also be a dietary supplement or a pharmaceutical formulation. As a dietary supplement, additional nutrients, such as minerals or amino acids may be included. The composition can also be a drink or food product. As used herein, the terms “drink” and “food” broadly refer to any kinds of liquid and solid/semi-solid materials, respectively, that are used for nourishing an animal, and for sustaining normal or accelerated growth of an animal including a human. Examples of the drink product include, but are not limited to, tea-based beverages, juice, coffee, and milk. Examples of the food product include jelly, cookies, cereals, chocolates, snack bars, herbal extracts, dairy products (e.g., ice cream, and yogurt), soy bean product (e.g., tofu), and rice products.

[0014] The above-described composition, in any of the forms described above, can be used for enhancing physical performance. As shown in the examples below, the composition improves overall strength, balance, fatigue recovery, intensity of physical exercise, and endurance to the exercise. It can also be used for treating diseases or disorders, such as arthritis, tumor, diabetes, sexual dysfunction, chronic constipation, inflammatory bowel disease; improving concentration or mood; and lowering cholesterol levels or blood pressure. A “tumor” refers to benign tumor, as well as malignant tumor (e.g., leukemia, colon cancer, kidney cancer, liver cancer, breast cancer, or lung cancer).

[0015] The terms “improving”, “treating,” and “lowering” refer to the administration of an effective amount of a composition of the invention to a subject, who needs to improve his physical performance or has one or more of the just-mentioned disorders, or a symptom or a predisposition of one of more of the disorders, with the purpose to improve physical performance or to cure, alleviate, relieve, remedy, or ameliorate one or more of the disorders, or the symptoms or the predispositions of one or more of them. The term “administration” covers oral or parenteral delivery to a subject a composition of the invention in any suitable form, e.g., food product, beverage, tablet, capsule, suspension, and solution. The term “parenteral” refers to subcutaneous, intracutaneous, intravenous, intramuscular, intraarticular, intraarterial, intrasynovial, intrasternal, intrathecal, intralesional, and intracranial injection, as well as various infusion techniques. An “effective amount” refers to a dose of the composition that is sufficient to provide a physical benefit (e.g., improving endurance) or a therapeutic benefit (e.g., lowering cholesterol levels or blood pressure). Both in vivo and in vitro studies can be conducted to determine optimal administration routes and doses.

[0016] The specific examples below are to be construed as merely illustrative, and not limitative of the remainder of the disclosure in any way whatsoever. Without further elaboration, it is believed that one skilled in the art can, based on the description herein, utilize the present invention to its fullest extent. All publications cited herein are hereby incorporated by reference in their entirety.

EXAMPLE 1

[0017] Composition A (1000 ml) was prepared by mixing the following ingredients at room temperature: 1000 ml of orange juice, 1000 mg of quercetin, 30 mg of vitamin B1, 85 mg of vitamin B2, 1000 mg of vitamin B3, 100 mg of vitamin B6, 120 μg of vitamin B 12, 1000 IU of vitamin E, and 1000 mg of caffeine. All ingredients were obtained from Spectrum Laboratory Products, Inc., Gardena, Calif.; Sigma, St. Louis, Mo.; and Aldrich, Milwaukee, Wis.

[0018] Ten male Spregue-Dawley rats, weighing 240-250 g, were obtained from Charles River Lab (Boston, Mass.). The rats were divided into Groups 1 and 2 (5 in each group). The rats in the Group 2 were administered by intragastric feeding with the just-described composition at a daily dose of 8 ml/rat (30 ml/kg body weight) for 48 days. The rats in Group 1 were administered with water.

[0019] At days 0, 14, 28, and 42 after the administration, blood samples were collected from the rats by supraorbital bleeding and various hematological parameters were determined using standard methods. The results are summarized in Tables 1 and 2 below.

TABLE 1
Effects of composition A on rat hematological parameters
Reference Day 0 Day 14 Day 28 Day 42
Parameter Range Group 1 Group 2 Group 1 Group 2 Group 1 Group 2 Group 1 Group 2
WBC 9.4-14.9 17.22 15.04 17.34 16.50 18.76 16.90 17.66 14.20
(THSN/UL)
RBC 6.2-9.0 6.09 5.94 6.63 6.60 7.43 7.20 7.99 7.72
(MILL/UL)
Hb 13.4-16.4 12.46 12.38 14.24 14.40 15.32 15.02 15.86 15.18
(GM/DL)
Hematocrit 40.0-49.0 (%) 37.80 37.44 42.30 43.26 45.56 45.00 47.04 45.86
MCV 52.0-66.0(FL) 62.20 63.20 63.80 65.40 61.60 62.60 58.80 59.40
MCH 17.7-19.1 20.46 20.84 21.50 21.82 20.68 20.86 19.88 19.72
(PICO GM)
MCHC 32.0-33.5 (%) 32.96 33.00 33.64 33.26 33.66 33.38 33.72 33.14
Platelet 780-1400 956.00 965.00 1084.60 1158.80 1078.40 1076.60 967.00 962.80
(THSN/UL)
BANDS 0.00-0.06 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
(THSN/UL)
Segmented 0.58-6.30 4.44 4.78 3.34 3.59 3.41 3.33 3.27 3.60
Neutrophiles (THSN/UL)
Lymphocyte 3.78-14.9 10.07 7.84 12.10 11.02 13.52 11.99 12.78 9.37
(THSN/UL)
Monocyte 0.02-1.20 3.43 2.15 1.67 1.67 1.49 1.30 1.24 1.03
(THSN/UL)
Eosinophiles 0.00-0.01 0.54 0.16 0.11 0.10 0.17 0.13 0.20 0.10
(THSN/UL)
Basophiles 0.00-0.00 0.14 0.11 0.12 0.12 0.17 0.15 0.16 0.09
(THSN/UL)
Atipicle 0.00-0.00 0.02 0.00 0.00 0.00 0.00 0.00 0.00 0.00
Lymphocyte (THSN/UL)
Metamyelocytes 0.00-0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
(THSN/UL)
Myelocytes 0.00-0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
(THSN/UL)
NRBC/100WBC 0-0 (/100WBC) 0.60 0.40 0.00 0.00 0.00 0.00 0.00 0.00
Reticulocyte 0.1-4.0 (%) 1 1 2.62 5.74 3.30 5.90 4.78 6.58

[0020]

TABLE 2
Effects of composition A on rat reticulocyte level
Reticulocyte level
in each rat
Group Ref. Range (%) Day 1# 2# 3# 4# 5# Average SD
1 0.1-4.0 14 2.9 2.9 2 4.9 4.4 2.62 0.96
2 0.1-4.0 14 5.8 4.9 7.5 5.8 4.7 5.74 2.15
1 0.1-4.0 28 3.1 2.2 2.2 7.2 6.8 3.30 2.5
2 0.1-4.0 28 4.8 6.5 5.4 5.5 7.3 5.90 1.3
1 0.1-4.0 42 4.8 9.2 9 5.5 5.4 4.78 2.14
2 0.1-4.0 42 7.5 6.2 6.1 6.4 6.7 6.58 0.16

[0021] As shown in Tables 1 and 2, the reticulocyte levels in the rats administered with composition B (Group 2) were higher than those in the rats administered with water (Group 1). For example, at Day 42, the average reticulocyte level in the rats of Group 2 (6.58%) was higher than that in the rats of Group 1 (4.78%) by 37.7%. On the other hand, other hematological parameters of the rats in the two groups did not differ significantly. See Table 1. These results indicate that composition A increases the reticulocyte level but does not affect other hematological parameters. Reticulocytes are immature, anucleated red blood cells (RBCs). An increase in the reticulocyte level and no changes in other hematological parameters suggest that composition A improves the renewal of RBC.

[0022] During the experiment, the body weight of each rat was monitored daily. No statistical difference was found between the two groups.

EXAMPLE 2

[0023] Composition B (1000 ml) was prepared by mixing the following ingredients at room temperature: 1000 ml of orange juice, 1000 mg of quercetin, 30 mg of vitamin B1, 85 mg of vitamin B2, 1000 mg of vitamin B3, 100 mg of vitamin B6, 120 μg of vitamin B 12, 1000 IU of vitamin E, 1000 mg of caffeine, 500 mg of epigallocatechin gallate, 500 mg of epicatechin, 500 mg of epicateqin gallate, 500 mg of epigallocatechin, and 500 mg of polypheron E.

[0024] Ten male Spregue-Dawley rats that weighed 240-250 g were divided into Groups 1 and 2 (5 in each group). The rats in Group 2 were administered by intragastric feeding with composition B at an average daily dose of 14 ml/kg body weight for 95 days. Those in Group 1 were administered with water.

[0025] Starting from Day 92 after the administration, each of the rats was trained on a Rota-Rod treadmill (Model 57750, Stoelting Co., Wood Dale, Ill.) for over 2 hours. At Day 95, after being trained for another 20 minutes, each of the rats was put on the treadmill and allowed to walk. The time for which each rat walked on the treadmill before falling off was recorded and the average time for the rats in Groups 1 and 2 determined. The experiments were repeated for three times (“Test A,” “Test B,” and “Test C”). The results are summarized in Table 3 below.

TABLE 3
Effects of composition B
Time on Rota-Rod treadmill (min)
Groups Test A Test B Test C
Group 1
#1 2.36 13.11 23.33
#2 10.69 16.02 44.21
#3 19.02 15.46 66.90
#4 2.99 16.67 16.09
#5 1.34 3.41 7.82
Average 7.28 12.93 31.67
SE 3.37 2.45 10.68
Group 2
#1 6.54 61.95 80.40
#2 16.16 21.54 41.73
#3 6.91 23.83 90.47
#4 24.19 20.42 202.82
#5 32.58 15.37 67.44
Average 17.28 28.62 96.57
SE 5.03 8.45 27.79

[0026] As shown in Table 3, the rats got used to the exercise and walked for longer time on the treadmill as the experiment went on. In all tests, the rats that had been administered with composition B walked on the treadmill longer than those that had been not. These results indicate that composition B enhanced the physical performance of rats. During the 95 days of administration, the body weight of each rat was monitored daily. No statistical difference was found between Groups 1 and 2. This result suggests the enhanced physical performance of the rats in Group 2 was not due to an increase in body mass.

Other Embodiments

[0027] All of the features disclosed in this specification may be combined in any combination. Each feature disclosed in this specification may be replaced by an alternative feature serving the same, equivalent, or similar purpose. Thus, unless expressly stated otherwise, each feature disclosed is only an example of a generic series of equivalent or similar features. From the above description, one skilled in the art can easily ascertain the essential characteristics of the present invention, and without departing from the spirit and scope thereof, can make various changes and modifications of the invention to adapt it to various usages and conditions. Thus, other embodiments are also within the scope of the following claims.

Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US7745486Jul 16, 2007Jun 29, 2010Quercegen Pharma LlcQuercetin-containing compositions
US7745487Jul 16, 2007Jun 29, 2010Quercegen Pharma LlcMethod for enhancing physical performance or immune system recovery from intense physical excercise with quercetin-containing compositions
US8044096Jan 16, 2009Oct 25, 2011Quercegen Pharmaceuticals LlcMethod for treating addiction using quercetin-containing compositions
US8110231Apr 10, 2006Feb 7, 2012Kraft Foods Global Brands LlcMethods for making improved texture cereal bars
US8202900Sep 18, 2008Jun 19, 2012Quercegen Pharmaceuticals LlcMethod for stabilizing quercetin
US8440704Dec 16, 2009May 14, 2013Quercegen Pharmaceuticals LlcQuercetin-containing compositions
US8507548Aug 23, 2011Aug 13, 2013Quercegen Pharmaceuticals LlcMethod for treating addiction using quercetin-containing compositions
US8574619Sep 5, 2008Nov 5, 2013Quercegen Pharmaceuticals, LLCReducing cholesterol levels with combined use of quercetin and statin
US8680053Jul 9, 2008Mar 25, 2014Quercegen Pharmaceuticals LlcImproving renal function with quercetin-containing compositions
US8901109Jun 23, 2010Dec 2, 2014Quercegen Pharmaceuticals LlcQuercetin-containing compositions
US8962678Jun 29, 2007Feb 24, 2015Kao CorporationSenescence inhibitor
EP2040708A2 *Jul 16, 2007Apr 1, 2009Thomas Christian LinesQuercetin-containing compositions
EP2231150A2 *Jan 16, 2009Sep 29, 2010Thomas Christian LinesMethod for treating addiction using quercetin-containing compositions
EP2310007A2 *Jul 8, 2009Apr 20, 2011Quercegen Pharmaceuticals LLC.Improving renal function with quercetin-containing compositions
Classifications
U.S. Classification426/72
International ClassificationA61K31/445, A61K31/714, A61K31/375, A61K31/4415, A61K31/51, A23L2/02, A23L1/302, A23L1/30, A61K31/355
Cooperative ClassificationA61K31/445, A61K31/355, A23L2/02, A23L1/3002, A23L1/302, A23V2002/00, A61K31/714, A61K31/51, A61K31/375, A61K31/4415
European ClassificationA61K31/51, A61K31/375, A61K31/714, A61K31/445, A61K31/355, A61K31/4415, A23L2/02, A23L1/302, A23L1/30B
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