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Publication numberUS20040158309 A1
Publication typeApplication
Application numberUS 10/409,559
Publication dateAug 12, 2004
Filing dateApr 8, 2003
Priority dateFeb 10, 2003
Also published asCN1321208C, CN1521284A, DE60309281D1, DE60309281T2, DE60309281T3, EP1444993A1, EP1444993B1, EP1444993B2, US8349249, US8403980, US20070221300, US20080312740, US20100222866, US20130166019
Publication number10409559, 409559, US 2004/0158309 A1, US 2004/158309 A1, US 20040158309 A1, US 20040158309A1, US 2004158309 A1, US 2004158309A1, US-A1-20040158309, US-A1-2004158309, US2004/0158309A1, US2004/158309A1, US20040158309 A1, US20040158309A1, US2004158309 A1, US2004158309A1
InventorsJurgen Wachter, Jens Trotzschel
Original AssigneeW. C. Heraeus Gmbh & Co. Kg
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Metal alloy for medical devices and implants
US 20040158309 A1
Abstract
The present invention relates to a medical device or implant made at least in part of a high strength, low modulus metal alloy comprising Niobium, Tantalum, and at least one element selected from the group consisting of Zirconium, Tungsten, and Molybdenum. The medical devices according to the present invention provide superior characteristics with regard to bio-compatibility, radio-opacity and MRI compatibility.
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Claims(21)
1. A medical implant or device fabricated from a metal alloy, said medical implant or device comprising components at least partially fabricated from a metal alloy comprising:
(a) between about 0.1 and 70 weight percent Niobium;
(b) between about 0.1 and 30 weight percent in total of at least one element selected from the group consisting of Tungsten, Zirconium and Molybdenum;
(c) up to 5 weight percent in total of at least one element selected from the group consisting of Hafnium, Rhenium and Lanthanides;
(d) and a balance of Tantalum,
wherein the alloy provides for a uniform beta structure, which is uniform and corrosion resistant, and has the ability for conversion oxidation or nitridization surface hardening of the medical implant or device.
2. A medical implant or device according to claim 1, wherein the Lanthanide is cerium.
3. A medical implant or device according to claim 1, wherein the alloy comprises between 0.1 and 15 weight percent Tungsten.
4. A medical implant or device according to claim 1, wherein the alloy comprises between 0.1 and 10 weight percent Zirconium.
5. A medical implant or device according to claim 1, wherein the alloy comprises between 0.1 and 20 weight percent Molybdenum.
6. A medical implant or device according to claim 1, wherein the alloy comprises between 5 and 25 weight percent Niobium.
7. A medical implant or device according to claim 3, wherein the alloy comprises about 10 weight percent Niobium and about 2.5 weight percent Tungsten.
8. A medical implant or device according to claim 3, wherein the alloy comprises about 10 weight percent Niobium and about 7.5 weight percent Tungsten.
9. A medical implant or device according to claim 4, wherein the alloy comprises about 10 weight percent Niobium and about 1 weight percent Zirconium.
10. A medical implant or device according to claim 4, wherein the alloy comprises about 10 weight percent Niobium and about 3 weight percent Zirconium.
11. A medical implant or device according to claim 1, wherein the medical device is a minimal-invasive device.
12. A medical implant according to claim 11, wherein the device is one of a catheter and a guide wire.
13. A medical implant or device according to claim 1, wherein the medical implant is an intra-cavernous implant.
14. A medical implant or device according to claim 13, wherein the implant is an intravascular implant.
15. A medical implant according to claim 13, wherein the medical implant is one of the group consisting of a stent, a stent graft, a stent graft connector and a heart valve repair device.
16. A medical implant or device according to claim 1, wherein the metal alloy has a surface that is passivated by oxidation or nitridization.
17. A medical implant or device according to claim 1, wherein the metal alloy has a surface that is one of electropolished, mechanically polished, micro blasted, roughened and sintered.
18. A medical implant or device according to claim 1, wherein the metal alloy has a surface coated with at least one of the group consisting of a polymer, a blend of polymers, a metal, a blend of metals, a ceramic and biomolecules.
19. A medical implant or device according to claim 18, wherein the surface of the metal alloy is coated by at least one of the group consisting of peptides, proteins, lipids, carbohydrates and nucleic acides.
20. A medical implant or device according to claim 1, wherein the metal alloy has a surface coated with at least one of stem cells and bioactive substance.
21. A medical implant or device according to claim 20, wherein the surface of the metal alloy is coated with at least one of the group consisting of drugs, antibiotics, growth factors, anti-inflammatory agents and anti-thrombogenic agents.
Description
  • [0001]
    The present invention relates to an improved metal alloy for medical implants or devices for desired material properties.
  • BACKGROUND OF THE INVENTION
  • [0002]
    A medical implant or device must satisfy a number of requirements. Factors affecting the choice of the medical implant or device and the material thereof are mainly all mechanical properties and biocompatibility. The material must not cause any inflammatory reaction or allergic reaction. Commonly used materials often include nickel, like medical grade 316L stainless steel, which contains about 16% nickel. For patients with an allergic reaction the implantation of such materials is contraindicated. Another consideration in material selection is the need for the implanting physician to be able to visualize the position of the medical implant or device during procedure to the desired target site in the body, and for purposes of examination from time to time thereafter at the implant site, typically by X-ray fluoroscopy.
  • [0003]
    With the growing importance of magnetic resonance imaging (MRI), MRI compatibility is desirable. The metal alloys commonly used for implantation (like stainless steel 316) induce a local disturbance of the magnetic field used in MRI, to the extent that imaging of surrounding tissue is impeded. Although alloys like Nitinol behave more favourably in MRI, their MRI compatibility is not considered to be sufficiently good.
  • [0004]
    This invention relates to medical devices or implants in general such as catheters, guide wires, stents, stent grafts and heart valve repair devices.
  • [0005]
    Stents are generally thin walled tubular-shaped devices composed of complex patterns of inter-connecting struts which function to hold open a segment of a blood vessel or other body lumen like oesophagus and urethra. Stent grafts are stents with a circumferential covering or lining and are suitable for supporting a dissected artery or intimal flap that can occlude a vessel lumen. Stents and stent grafts are typically implanted by use of a catheter. Initially they are maintained in a radially compressed state to manoeuvre them through the lumen. Once in position, they are deployed. The material from which the vascular prosthesis like stents or stent grafts is constructed must allow the prosthesis to undergo expansion, which typically requires substantial deformation. Once expanded the stent must maintain its size and shape and must be capable of withstanding the structural loads, namely radial compressive forces, imposed on the stent as it supports the walls of a vessel lumen. The wall of the prosthesis must be sufficiently thick, depending on the stent material, not only to withstand the vessel wall recoil but also allow the stent to be seen on the fluoroscope. Finally, the prosthesis material must be biocompatible so as not to trigger any adverse vascular responses like restenosis or thrombus formation in the treated vessel.
  • [0006]
    For medical devices such as all kind of catheters and guide wires special mechanical properties are desired to have perfect trackability and pushability during the intervention. Moreover, good radio-opacity and MRI compatibility are essential in order to survey medical procedures via x-ray and MRI. Finally also for these medical devices biocompatibility is a must.
  • [0007]
    In the past years increased effort was undertaken to find new materials for medical implants and devices bearing superior characteristics over commonly used metals like stainless steel or titanium. Numerous publications focus on titanium alloys aiming at corrosion resistant, high strength and biocompatible alloys. As described for example in U.S. Pat. No. 6,312,455, US 2001/0007953, and WO 99/58184 many Titanium-alloys thereof are super-elastic or shape memory alloys. A pseudo-elastic β-titanium alloy fabricated from Titanium, Molybdenum, Aluminium and optionally Niobium, Chrome and Vanadium is described in U.S. Pat. No. 6,258,182. EP 0 788 802 provides a self-expanding stent consisting of a titanium alloy including at least about 68 weight percent titanium and optionally Niobium, Zirconium, and Molybdenum. U.S. Pat. No. 6,238,491 and WO 00/68448 describe a Niobium-Titanium-Zirconium-Molybdenum alloy for medical devices providing a uniform β-structure, which is corrosion resistant, and can be processes to develop high-strength and low-modulus. The alloy comprises 29 to 70 weight percent Niobium, 10 to 46 weight percent Zirconium, 3 to 15 weight percent Molybdenum and a balance of Titanium. In another approach Davidson (EP 0 601 804) employ an alloy consisting essentially of Titanium, 10 to 20 or 25 to 50 weight percent Niobium and optionally up to 20 weight percent Zirconium, the alloy having an elastic modulus less than 90 GPa. Similar Titanium-alloys for medical implants also published by Davidson comprise Titanium, 10 to 20 or 35 to 50 weight percent Niobium and optionally up to 20 weight percent each Zirconium and Tantalum (EP 0 437 079) or Titanium, 10 to 20 or 35 to 50 weight percent each Niobium and Tantalum and optionally up to 20 weight percent Zirconium (U.S. Pat. No. 5,690,670). EP 0 707 085 also provides a low modulus, bio-compatible Titanium-base alloy for medical devices consisting of 20 to 40 weight percent Niobium, 4,5 to 25 weight percent Tantalum, 2,5 to 13 weight percent Zirconium and the balance Titanium. A further high strength, low modulus and biocompatible Titanium-alloy is laid open in U.S. Pat. No. 4,857,269 and EP 0 359 446 consisting of Titanium and up to 25 weight percent Niobium, Zirconium, and Molybdenum. EP 1 046 722 describes a corrosion resistant Titanium-Zirconium-type alloy for medical appliances consisting of 25 to 50 weight percent Titanium, 5 to 30 weight percent Niobium, 5 to 40 weight percent Tantalum and 25 to 60 weight percent Zirconium.
  • [0008]
    Further approaches to develop biocompatible, high strength alloys which are also sufficiently radio-opaque and do not contain Titanium are described in U.S. Pat. No. 6,478,815 and WO 02/43787. Both documents reveal stents made from at least 90 weight percent Niobium. Niobium is a relatively soft and ductile metal, which is alloyed with traces of other elements, e.g. Zirconium, Tantalum or Titanium for reinforcement of the alloy. However, Niobium surfaces cannot be electropolished because of their tendency to smear (?). Stents fabricated from binary Tantalum-Alloys, namely Tantalum-Niobium and Tantalum-Tungsten, are disclosed in WO 02/05863.
  • DETAILED DESCRIPTION OF THE INVENTION
  • [0009]
    Aim of the present invention is to provide an inventive material for medical implants and devices, which comprises favourable mechanical properties, excellent biocompatibility, optimal radio-opacity while at the same time exhibiting minor image artefact in MRI examination (MRI compatibility) and does therefore overcome the drawbacks of recently available metals for medical purposes.
  • [0010]
    The alloy fulfils all mechanical and structural requirements according to its function in a medical implant or device. Moreover, the device is sufficiently radio-opaque to allow for good imaging of the device under x-ray without the addition of an extra layer or portion of radio-opaque material. Also, the device is not overly bright and therefore does not obscure the image of the surrounding tissue, as would be the case with a device made from an extremely dense material. In addition, the device is MRI safe and compatible, preferably also visible under MRI.
  • [0011]
    Surprisingly, it has been found that the desired properties can be given to a metal alloy comprising Tantalum, Niobium and at least one element selected from the group consisting of Tungsten, Zirconium and Molybdenum.
  • [0012]
    Tantalum is known as a very hard metal with a high melting point, high strength, and good ductility and is almost completely inert at body temperature. Tantalum has a high atomic number (73) and a density of 16.6 g/cm3 resulting in a high radio-opacity. Therefore, medical implants or devices made of pure tantalum have the disadvantage that they are excessively radio-opaque, leading to a completely black area on the x-ray image in the region where the medical implant or device is located.
  • [0013]
    The radio-opacity of the inventive metal alloy is adjusted by adding further elements possessing higher or lower atomic numbers to the tantalum based alloy, which lowers the density of the alloy. Niobium has an atomic mass of approximately half that of Tantalum. Thus, tailoring the density of the inventive alloy by variation of the Niobium portion allows achievement of appropriate radio-opacity for each medical device or implant manufactured at least in part of the inventive alloy. It is possible to fabricate an alloy according to the present invention, which is sufficiently radio-opaque to be readily visualized under x-ray during medical procedures and yet is not so radio-opaque as to interfere with the visualization of surrounding body tissue.
  • [0014]
    The alloys of the invention show excellent melting and mixing properties with excellent uniformity since Niobium and tantalum are arbitrarily miscible. Varying the amount of Tungsten, Zirconium and Molybdenum, or optionally, the amount of Cerium, Rhenium, or Hafnium, allows adjustment of the granular size of the alloy.
  • [0015]
    Surprisingly, the alloy according to the present invention is stronger than pure tantalum and in specific compositions even stronger than stainless steel. In a preferred embodiment a stent is manufactured from the alloy of the invention comprising a tailored radio-opacity while having a reduced wall thickness. Such a stent combines desired visibility under x-ray and excellent radial force with minimised delivery profile and less turbulence when employed in the vessel.
  • [0016]
    An additional advantage of the inventive alloy is the formation of a passive oxide film primarily composed of Tantalum-oxide (Ta2O5), which is generally more durable and more corrosion resistant than for example the chromium-oxide film formed during the passivation of stainless steel.
  • [0017]
    The inventive alloy can be easily cold-worked to increase strength and reduce elastic modulus. It is possible to form a hard, abrasion resistant surface on the inventive alloy through standard oxidation and nitridizing methods known by those skilled in the art. The presence of a hard, inert, abrasion resistant surface layer presents an important option for medical implants and devices in which it is desirable to have lower friction and wear, electrical insulation and improved corrosion resistance.
  • [0018]
    To further improve the biocompatibility of the medical implant or device fabricated at least in part from the inventive alloy, at least a portion of the surface of the inventive alloy can be conversion surface hardened and/or coated. Such coatings can include, but are not limited to a polymer, a blend of polymers, a metal, a blend of metals, a ceramic and/or biomolecules, in particular peptides, proteins, lipids, carbohydrates and/or nucleic acids (e.g. collagen, heparin, fibrin, phosphorylcholine, cellulose, morphogenic proteins or peptides, growth factors). Further-more the alloy surface or the coatings can comprise stem cells and/or a bioactive substances, in particular drugs, antibiotics, growth factors, anti-inflammatory agents and/or anti-thrombogenic agents. Further, the surface can be modified by electropolishing or mechanical polishing for formation of a completely smooth surface, sintering to achieve a porous coating as for example described in EP0601804, or by roughening procedures or microblasting, in particular sand-blasting, to achieve a rough surface.
  • [0019]
    The inventive alloy is useful in the manufacturing of a variety of medical implants and devices. The manufacture of medical devices from the invention alloy includes minimal-invasive devices, in particular guide wires, catheters (balloon catheters, guiding catheter, angiographic catheters, functional catheters, . . . ), intra-cavernous implants, in particular intra-oesophagus, intra-urethra, intra-tracheal implants and intra-vascular implants, in particular stents, stent grafts, stent graft connector, heart valve repair device or filters.
  • [0020]
    Preferred alloys contain the following elements:
  • [0021]
    (a) between about 0,1 and 70 weight percent Niobium,
  • [0022]
    (b) between about 0,1 and 30 weight percent in total of at least one element selected from the group consisting of Tungsten, Zirconium and Molybdenum,
  • [0023]
    (c) up to 5 weight percent in total of at least one element selected from the group consisting of Hafnium, Rhenium and Lanthanides, in particular Cerium,
  • [0024]
    (d) and a balance of Tantalum
  • [0025]
    The alloys preferably provide for a uniform beta structure, which is uniform and corrosion resistant, and have the ability for conversion oxidation or nitridization surface hardening of the medical implant or device.
  • [0026]
    The tungsten content is preferably between 0,1 and 15 weight percent.
  • [0027]
    The zirconium content is preferably between 0,1 and 10 weight percent.
  • [0028]
    The molybdenum content is preferably between 0,1 and 20 weight percent an more preferably between 0,1 and 10 weight percent.
  • [0029]
    The niobium content is preferably between 5 and 25 weight percent.
  • [0030]
    Especially preferred alloys contain about 10 weight percent Niobium and about 2,5 weight percent Tungsten.
  • [0031]
    Also preferred are alloys which comprise about 10 weight percent Niobium and about 7,5 weight percent Tungsten.
  • [0032]
    Also preferred are alloys which comprise about 10 weight percent Niobium and about 1 weight percent Zirconium.
  • [0033]
    Also preferred are alloys which comprise about 10 weight percent Niobium and about 3 weight percent Zirconium.
  • [0034]
    The invention also relates to medical implants or devices fabricated from the above-mentioned alloys, e.g. minimal-invasive devices, in particular catheters or guide wires, or intra-cavernous implants, in particular intravascular implants, such as stents, a stent grafts, stent graft connectors or heart valve repair devices.
  • [0035]
    In the above implants and devices the surface of the metal alloys may be passivated by oxidation or nitridization, or may be electropolished, mechanically polished, micro blasted, roughened or sintered, or may be coated with a polymer, a blend of polymers, a metal, a blend of metals, a ceramic and/or biomolecules, in particular peptides, proteins, lipids, carbohydrates and/or nucleic acids; or may be coated with stem cells and/or a bioactive substance, in particular drugs, antibiotics, growth factors, anti-inflammatory agents and/or anti-thrombogenic agents.
  • EXAMPLE
  • [0036]
    The invention may be carried out with an alloy of the following composition:
  • [0037]
    Ta: 71,5
  • [0038]
    Nb: 27,5
  • [0039]
    Zr: 1,0
  • [0040]
    Methods of producing the alloy are known to the person skilled in the art.
Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US3173784 *Dec 22, 1958Mar 16, 1965Union Carbide CorpColumbium base alloy
US3186837 *Feb 28, 1961Jun 1, 1965California Research CorpColumbium-tantalum base alloy
US3188206 *Dec 20, 1961Jun 8, 1965Fansteel Metallurgical CorpColumbium alloy
US3249429 *Dec 27, 1963May 3, 1966Clo E ArmantroutTantalum brazing alloy
US3254995 *Apr 13, 1962Jun 7, 1966Powder Alloys CorpHeavy metal alloys
US3297438 *Apr 6, 1964Jan 10, 1967United Aircraft CorpHigh temperature strength columbium base alloys
US3317314 *Nov 18, 1959May 2, 1967Union Carbide CorpColumbium-base alloy
US3341370 *Dec 10, 1963Sep 12, 1967United Aircraft CorpHafnium-containing columbium-base alloys
US3395012 *Nov 8, 1965Jul 30, 1968Birmingham Small Arms Co LtdNiobium alloys
US3592639 *Aug 19, 1968Jul 13, 1971Fansteel IncTantalum-tungsten alloy
US4526749 *Jul 2, 1984Jul 2, 1985Cabot CorporationTantalum-columbium-molybdenum-tungsten alloy
US4857269 *Sep 9, 1988Aug 15, 1989Pfizer Hospital Products Group Inc.High strength, low modulus, ductile, biopcompatible titanium alloy
US4859257 *Oct 4, 1988Aug 22, 1989Fansteel Inc.Fine grained embrittlement resistant tantalum wire
US5176762 *Dec 23, 1986Jan 5, 1993United Technologies CorporationAge hardenable beta titanium alloy
US5477864 *Aug 26, 1993Dec 26, 1995Smith & Nephew Richards, Inc.Cardiovascular guidewire of enhanced biocompatibility
US5545227 *Jun 20, 1994Aug 13, 1996Smith & Nephew Richards, Inc.Biocompatible low modulus medical implants
US5690670 *Jun 6, 1995Nov 25, 1997Davidson; James A.Stents of enhanced biocompatibility and hemocompatibility
US5930332 *Dec 3, 1996Jul 27, 1999General Electric CompanyMethod for connecting a molybdenum-based alloy structure to a structure formed from a more ductile alloy, and related articles
US6200685 *Feb 2, 1999Mar 13, 2001James A. DavidsonTitanium molybdenum hafnium alloy
US6238491 *May 5, 1999May 29, 2001Davitech, Inc.Niobium-titanium-zirconium-molybdenum (nbtizrmo) alloys for dental and other medical device applications
US6258182 *Mar 5, 1999Jul 10, 2001Memry CorporationPseudoelastic β titanium alloy and uses therefor
US6312455 *Apr 25, 1997Nov 6, 2001Nitinol Devices & ComponentsStent
US6379380 *Aug 29, 2000Apr 30, 2002Stanley SatzMetal stent containing radioactivatable isotope and method of making same
US6387121 *Aug 8, 2000May 14, 2002Inflow Dynamics Inc.Vascular and endoluminal stents with improved coatings
US6478815 *Sep 18, 2000Nov 12, 2002Inflow Dynamics Inc.Vascular and endoluminal stents
US7087077 *Apr 13, 2000Aug 8, 2006Elephant Dental BvBiomedical aid or implant
US20010007953 *Apr 25, 1997Jul 12, 2001Carl J. EvensStent
US20020008021 *Apr 10, 2001Jan 24, 2002Martin WeigertSputtering target for depositing silicon layers in their nitride or oxide form and a process for its preparation
US20020111694 *Dec 6, 2001Aug 15, 2002Bioti AsMedical prosthetic devices and implants having improved biocompatibility
US20020139667 *Mar 29, 2001Oct 3, 2002Guangxin WangMethods for electrically forming materials; and mixed metal materials
US20030037847 *May 14, 2002Feb 27, 2003Michaluk Christopher A.High purity tantalum, products containing the same, and methods of making the same
US20030125808 *Dec 6, 2002Jul 3, 2003Gordon HunterIn-situ oxidized textured surfaces for prosthetic devices and method of making same
US20040126613 *Dec 27, 2002Jul 1, 2004Bernard BewlayCoatings, method of manufacture, and the articles derived therefrom
US20040168751 *Jan 8, 2004Sep 2, 2004Wu Ming H.Beta titanium compositions and methods of manufacture thereof
US20040243133 *Mar 5, 2004Dec 2, 2004Therics, Inc.Method and system for manufacturing biomedical articles, such as using biomedically compatible infiltrant metal alloys in porous matrices
US20040249447 *Mar 30, 2004Dec 9, 2004Boylan John F.Radiopaque and MRI compatible nitinol alloys for medical devices
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US7684860Mar 23, 2007Mar 23, 2010Medtronic, Inc.Components for reducing image distortion
US7727273Jan 13, 2005Jun 1, 2010Boston Scientific Scimed, Inc.Medical devices and methods of making the same
US7831096 *Nov 17, 2006Nov 9, 2010General Electric CompanyMedical navigation system with tool and/or implant integration into fluoroscopic image projections and method of use
US7879071May 9, 2003Feb 1, 2011Integrated Vascular Systems, Inc.Closure device and methods for making and using them
US7887555Jul 9, 2003Feb 15, 2011Integrated Vascular Systems, Inc.Closure device and methods for making and using them
US7890165Feb 16, 2010Feb 15, 2011Medtronic, Inc.Implantable medical device with reduced MRI image distortion
US7901428Oct 3, 2002Mar 8, 2011Integrated Vascular Systems, Inc.Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US7918873Sep 18, 2006Apr 5, 2011Abbott Vascular Inc.Surgical staple
US7927737Mar 23, 2007Apr 19, 2011Medtronic, Inc.Implantable medical device and lithium battery
US7931669May 17, 2002Apr 26, 2011Integrated Vascular Systems, Inc.Integrated vascular device with puncture site closure component and sealant and methods of use
US7938854 *May 20, 2010May 10, 2011Boston Scientific Scimed, Inc.Medical devices and methods of making the same
US7972375 *Feb 5, 2007Jul 5, 2011Boston Scientific Scimed, Inc.Endoprostheses including metal matrix composite structures
US8007512Oct 8, 2003Aug 30, 2011Integrated Vascular Systems, Inc.Plunger apparatus and methods for delivering a closure device
US8128644Sep 19, 2003Mar 6, 2012Integrated Vascular Systems, Inc.Closure device and methods for making and using them
US8131368Mar 23, 2007Mar 6, 2012Medtronic, Inc.Implantable medical device with material for reducing MRI image distortion
US8182497Oct 4, 2010May 22, 2012Integrated Vascular Systems, Inc.Closure device
US8192459Jun 5, 2012Abbott Vascular Inc.Blood vessel closure clip and delivery device
US8202283Nov 12, 2010Jun 19, 2012Integrated Vascular Systems, Inc.Methods for manufacturing a clip and clip
US8202293Jun 20, 2008Jun 19, 2012Integrated Vascular Systems, Inc.Clip applier and methods of use
US8202294Dec 20, 2010Jun 19, 2012Integrated Vascular Systems, Inc.Clip applier and methods of use
US8226681Jun 25, 2007Jul 24, 2012Abbott LaboratoriesMethods, devices, and apparatus for managing access through tissue
US8236026Aug 7, 2012Integrated Vascular Systems, Inc.Closure device and methods for making and using them
US8257390Sep 4, 2012Integrated Vascular Systems, Inc.Closure device and methods for making and using them
US8293261Jan 26, 2006Oct 23, 2012Terumo Kabushiki KaishaIntravascular implant
US8303624Mar 15, 2010Nov 6, 2012Abbott Cardiovascular Systems, Inc.Bioabsorbable plug
US8313497Nov 20, 2012Abbott LaboratoriesClip applier and methods of use
US8323312Jun 9, 2009Dec 4, 2012Abbott LaboratoriesClosure device
US8340759Apr 22, 2011Dec 25, 2012Medtronic, Inc.Large-pitch coil configurations for a medical device
US8349249Jan 8, 2013Heraeus Precious Metals Gmbh & Co. KgMetal alloy for medical devices and implants
US8398656Mar 2, 2011Mar 19, 2013Integrated Vascular Systems, Inc.Clip applier and methods of use
US8398676Mar 19, 2013Abbott Vascular Inc.Closure device
US8403980Mar 26, 2013Heraeus Materials Technology Gmbh & Co. KgMetal alloy for medical devices and implants
US8469995Jun 4, 2012Jun 25, 2013Abbott Vascular Inc.Blood vessel closure clip and delivery device
US8486092Mar 11, 2009Jul 16, 2013Integrated Vascular Systems, Inc.Closure device and methods for making and using them
US8486108Feb 1, 2006Jul 16, 2013Integrated Vascular Systems, Inc.Closure device and methods for making and using them
US8492002 *Sep 23, 2009Jul 23, 2013Sandvik Intellectual Property AbTitanium-based alloy
US8518057Sep 13, 2012Aug 27, 2013Abbott LaboratoriesClip applier and methods of use
US8529587Jun 6, 2012Sep 10, 2013Integrated Vascular Systems, Inc.Methods of use of a clip applier
US8548591Feb 16, 2012Oct 1, 2013Medtronic Inc.Implantable medical device
US8556930Jun 28, 2006Oct 15, 2013Abbott LaboratoriesVessel closure device
US8579932Feb 24, 2004Nov 12, 2013Integrated Vascular Systems, Inc.Sheath apparatus and methods for delivering a closure device
US8585836Jun 18, 2012Nov 19, 2013Integrated Vascular Systems, Inc.Methods for manufacturing a clip and clip
US8590760May 24, 2005Nov 26, 2013Abbott Vascular Inc.Surgical stapler
US8597325Nov 29, 2010Dec 3, 2013Integrated Vascular Systems, Inc.Apparatus and methods for providing tactile feedback while delivering a closure device
US8603116Aug 4, 2010Dec 10, 2013Abbott Cardiovascular Systems, Inc.Closure device with long tines
US8603136May 3, 2007Dec 10, 2013Integrated Vascular Systems, Inc.Apparatus and methods for providing tactile feedback while delivering a closure device
US8603137Nov 1, 2010Dec 10, 2013Abbott Cardiovascular Systems, Inc.Methods and systems for establishing hemostasis relative to a puncture
US8639352Apr 6, 2009Jan 28, 2014Medtronic, Inc.Wire configuration and method of making for an implantable medical apparatus
US8657852Mar 8, 2013Feb 25, 2014Abbott Vascular Inc.Closure device
US8660662Apr 22, 2011Feb 25, 2014Medtronic, Inc.Low impedance, low modulus wire configurations for a medical device
US8672953Jun 6, 2011Mar 18, 2014Abbott LaboratoriesTissue closure system and methods of use
US8685047Feb 7, 2011Apr 1, 2014Abbott Vascular, Inc.Scaffold device for preventing tissue trauma
US8690910Mar 31, 2006Apr 8, 2014Integrated Vascular Systems, Inc.Closure device and methods for making and using them
US8728119Feb 18, 2011May 20, 2014Abbott Vascular Inc.Surgical staple
US8758396Apr 27, 2006Jun 24, 2014Integrated Vascular Systems, Inc.Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US8758398Sep 7, 2007Jun 24, 2014Integrated Vascular Systems, Inc.Apparatus and method for delivering a closure element
US8758399Aug 2, 2010Jun 24, 2014Abbott Cardiovascular Systems, Inc.Expandable bioabsorbable plug apparatus and method
US8758400Nov 8, 2010Jun 24, 2014Integrated Vascular Systems, Inc.Closure system and methods of use
US8784447Apr 25, 2005Jul 22, 2014Abbott Vascular Inc.Surgical stapler
US8808310Feb 14, 2007Aug 19, 2014Integrated Vascular Systems, Inc.Resettable clip applier and reset tools
US8820602Nov 19, 2010Sep 2, 2014Abbott LaboratoriesModular clip applier
US8821534Dec 6, 2010Sep 2, 2014Integrated Vascular Systems, Inc.Clip applier having improved hemostasis and methods of use
US8852220Sep 7, 2011Oct 7, 2014Abbott Cardiovascular Systems, Inc.Thrombus penetrating devices, systems, and methods
US8858594Dec 18, 2009Oct 14, 2014Abbott LaboratoriesCurved closure device
US8893947Dec 17, 2007Nov 25, 2014Abbott LaboratoriesClip applier and methods of use
US8905937Feb 26, 2009Dec 9, 2014Integrated Vascular Systems, Inc.Methods and apparatus for locating a surface of a body lumen
US8920442Aug 23, 2006Dec 30, 2014Abbott Vascular Inc.Vascular opening edge eversion methods and apparatuses
US8923969Sep 27, 2013Dec 30, 2014Medtronic, Inc.Implantable medical device
US8926633Jun 19, 2006Jan 6, 2015Abbott LaboratoriesApparatus and method for delivering a closure element
US8926656Jan 10, 2011Jan 6, 2015Integated Vascular Systems, Inc.Clip applier and methods of use
US8956388Apr 21, 2008Feb 17, 2015Integrated Vascular Systems, Inc.Integrated vascular device with puncture site closure component and sealant
US9050068May 20, 2013Jun 9, 2015Abbott LaboratoriesClip applier and methods of use
US9050087May 14, 2008Jun 9, 2015Integrated Vascular Systems, Inc.Integrated vascular device with puncture site closure component and sealant and methods of use
US9055932Aug 26, 2011Jun 16, 2015Abbott Cardiovascular Systems, Inc.Suture fastener combination device
US9060769May 1, 2008Jun 23, 2015Abbott Vascular Inc.Surgical stapler
US9089311Jan 8, 2010Jul 28, 2015Abbott Vascular Inc.Vessel closure devices and methods
US9089674Sep 15, 2006Jul 28, 2015Integrated Vascular Systems, Inc.Apparatus and methods for positioning a vascular sheath
US9149265Feb 26, 2011Oct 6, 2015Abbott Cardiovascular Systems, Inc.Hinged tissue support device
US9149276Mar 21, 2011Oct 6, 2015Abbott Cardiovascular Systems, Inc.Clip and deployment apparatus for tissue closure
US9173644Jan 8, 2010Nov 3, 2015Abbott Vascular Inc.Closure devices, systems, and methods
US9241696Oct 29, 2009Jan 26, 2016Abbott Vascular Inc.Closure device
US9241706Jan 23, 2012Jan 26, 2016Abbott LaboratoriesSuture locking device and methods
US20060153729 *Jan 13, 2005Jul 13, 2006Stinson Jonathan SMedical devices and methods of making the same
US20060210880 *Jan 31, 2006Sep 21, 2006Medtronic, Inc.Current collector
US20060229711 *Apr 4, 2006Oct 12, 2006Elixir Medical CorporationDegradable implantable medical devices
US20060259126 *May 5, 2005Nov 16, 2006Jason LenzMedical devices and methods of making the same
US20070178383 *Apr 26, 2006Aug 2, 2007Viavattine Joseph JCurrent collector
US20070248881 *Mar 23, 2007Oct 25, 2007Medtronic, Inc.Implantable medical device and lithium battery
US20080103543 *Oct 31, 2006May 1, 2008Medtronic, Inc.Implantable medical device with titanium alloy housing
US20080118115 *Nov 17, 2006May 22, 2008General Electric CompanyMedical navigation system with tool and/or implant integration into fluoroscopic image projections and method of use
US20080188922 *Feb 5, 2007Aug 7, 2008Boston Scientific Scimed, Inc.Endoprostheses including metal matrix composite structures
US20080262589 *Jan 26, 2006Oct 23, 2008Terumo Kabushiki KaishaIntravascular Implant
US20080312740 *Feb 19, 2008Dec 18, 2008Jurgen WachterMetal alloy for medical devices and implants
US20090093875 *Apr 30, 2008Apr 9, 2009Abbott LaboratoriesDrug eluting stents with prolonged local elution profiles with high local concentrations and low systemic concentrations
US20100086794 *Sep 23, 2009Apr 8, 2010Susanne NorgrenTitanium-based alloy
US20100145183 *Feb 16, 2010Jun 10, 2010Medtronic, Inc.Implantable medical device
US20100222866 *Sep 2, 2010Jurgen WachterMetal alloy for medical devices and implants
US20100228336 *Sep 9, 2010Stinson Jonathan SMedical devices and methods of making the same
US20100256718 *Apr 6, 2009Oct 7, 2010Medtronic, Inc.Wire Configuration and Method of Making for an Implantable Medical Apparatus
US20130226281 *Feb 20, 2013Aug 29, 2013Tohoku UniversityCo-BASED ALLOY FOR LIVING BODY AND STENT
EP1838359A2Jan 11, 2006Oct 3, 2007Boston Scientific LimitedMedical devices comprising alloys
WO2010081101A2Jan 11, 2010Jul 15, 2010Abbott Vascular Inc.Closure devices, systems, and methods
WO2010081102A2Jan 11, 2010Jul 15, 2010Abbott Vascular Inc.Closure devices, systems, and methods
WO2010081106A1Jan 11, 2010Jul 15, 2010Abbott Vascular IncClosure devices, systems, and methods
Classifications
U.S. Classification623/1.13, 604/528, 623/924, 623/2.24, 623/11.11, 623/1.15
International ClassificationC22C27/02, A61F2/24, A61L31/00, A61M25/01, A61L31/18, A61L27/04, A61F2/84, A61L31/02, A61F2/06, C22C30/00
Cooperative ClassificationA61L31/18, A61L31/022, C22C27/02, C22C27/00, A61L27/047, C22C30/00
European ClassificationC22C30/00, A61L31/18, A61L31/02B, A61L27/04R, C22C27/02, C22C27/00
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