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Publication numberUS20050118073 A1
Publication typeApplication
Application numberUS 10/997,714
Publication dateJun 2, 2005
Filing dateNov 24, 2004
Priority dateNov 26, 2003
Also published asUS8282896, US20100183481
Publication number10997714, 997714, US 2005/0118073 A1, US 2005/118073 A1, US 20050118073 A1, US 20050118073A1, US 2005118073 A1, US 2005118073A1, US-A1-20050118073, US-A1-2005118073, US2005/0118073A1, US2005/118073A1, US20050118073 A1, US20050118073A1, US2005118073 A1, US2005118073A1
InventorsGeoffrey Facer, Hany Nassef
Original AssigneeFluidigm Corporation
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Devices and methods for holding microfluidic devices
US 20050118073 A1
Abstract
Carriers or holders for holding microfluidic devices are provided. Some of the carriers that are provided include a hydration control device and/or a source of controlled fluid pressure to facilitate use of the carrier in conducting various types of analyses.
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Claims(20)
1. A carrier for holding a microfluidic device comprising:
a housing, said housing defining a chamber therein and having a receiving portion for receiving said microfluidic device;
a connection block for retaining said microfluidic device, wherein said connection block is attachable to said microfluidic device through one or more prongs, and said microfluidic device, when retained by said connection block, is insertable into said receiving portion of said housing.
2. The carrier of claim 1 wherein said one or more prongs is two or more prongs.
3. The carrier of claim 1 wherein at least one of said one or more prongs is a tube.
4. The carrier of claim 1 wherein said receiver has at least one slot for guiding and retaining said microfluidic device when inserted into said receiving portion.
5. The carrier of claim 1 wherein said receiver further comprises one or more pipette supports for guiding a pipette tip into said microfluidic device when inserted into said receiving portion.
6. The carrier of claim 1 further comprising an accumulator for providing fluid under pressure to said microfluidic device when inserted into said receiving portion.
7. The carrier of claim 6 wherein said accumulator further comprises a check valve.
8. The carrier of claim 1 wherein said housing comprises a housing base and a housing cover.
9. The carrier of claim 8 further comprising an accumulator attached to said housing.
10. The carrier of claim 8 wherein said housing cover and said housing base are sealed together by a gasket.
11. The carrier of claim 1 further comprising a humidity control material therein.
12. The carrier of claim 1 1 wherein said humidity control material is selected from the group consisting of a sponge, a gel matrix, a desiccant, and a woven material.
13. The carrier of claim 1 wherein said housing is made from a polymer.
14. The carrier of claim 13 wherein said polymer is either polycarbonate or acrylic or polystyrene.
15. The carrier of claim 6 wherein said accumulator is in fluid communication with said connection block through one or more accumulator-connection block tubes.
16. The carrier of claim 15 wherein said accumulator-connection block tubes is flexible.
17. The carrier of claim 1 wherein a first tube of said one or more tubes is in communication with said microfluidic device for controlling one or more first valves.
18. The carrier of claim 1 wherein a second tube of said one or more tubes is in communication with said microfluidic device for controlling one or more second valves.
19. The carrier of claim 17 wherein said first valves are interface valves.
20. The carrier of claim 18 wherein said second valves are containment valves.
Description
    CROSS-REFERENCES TO RELATED APPLICATIONS
  • [0001]
    This application claims the benefit of U.S. Provisional Application No. 60/525,245, filed Nov. 26, 2003, which is incorporated herein by reference in its entirety for all purposes.
  • BACKGROUND OF THE INVENTION
  • [0002]
    Microfluidic based protein crystallization devices and methods have been described in co-pending U.S. patent application Ser. No. 10/117,978 filed on Apr. 5, 2002, by Hansen, et al., which is herein incorporated by reference in its entirety for all purposes and the specific purpose of teaching microfluidic based protein crystallization devices and methods. Hansen described a carrier for holding the microfluidic devices described by Hansen in which a microfluidic device was placed onto a bottom plate and retained by a top plate.
  • BRIEF SUMMARY OF THE INVENTION
  • [0003]
    The invention provides, in one aspect, for a carrier for holding a microfluidic device comprising: a housing, the housing defining a chamber therein and having a receiving portion for receiving the microfluidic device; a connection block for retaining the microfluidic device, wherein the connection block is attachable to the microfluidic device through one or more prongs, and the microfluidic device, when retained by the connection block, is insertable into the receiving portion of the housing. Other embodiments include having the one or more prongs be two or more prongs, having at least one of the one or more prongs is a tube, having the receiver has at least one slot for guiding and retaining the microfluidic device when inserted into the receiving portion, having the receiver further comprises one or more pipette supports for guiding a pipette tip into the microfluidic device when inserted into the receiving portion, including one or more accumulators for providing fluid under pressure to the microfluidic device when inserted into the receiving portion, preferably where at least one accumulator further comprises a check valve, having the housing comprises a housing base and a housing cover, preferably where an accumulator is attached to the housing, and preferably where the housing cover and the housing base are sealed together by a gasket, including a humidity control material within the housing for providing humidity control, preferably where the humidity control material is selected from the group consisting of a sponge, a gel matrix, a desiccant, and a woven material, having the housing is preferably be made from a polymer, more preferably where the polymer is either polycarbonate or acrylic or polystyrene, preferably where the accumulator is in fluid communication with the connection block through one or more accumulator-connection block tubes, wherein the accumulator-connection block tubes are preferably flexible, having a first tube of the one or more tubes is in communication with the microfluidic device for controlling one or more first valves, preferably wherein a second tube of the one or more tubes is in communication with the microfluidic device for controlling one or more second valves, for example, but not limited to, wherein the first valves are interface valves and/or wherein the second valves are containment valves.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0004]
    FIG. 1 depicts a carrier described in the prior art.
  • [0005]
    FIG. 2 depicts a perspective view of a preferred embodiment of the invention.
  • DETAILED DESCRIPTION OF THE INVENTION
  • [0006]
    The invention provides for devices, and methods for using such devices, for holding and manipulating microfluidic devices, in particular, multilayer elastomeric microfluidic devices wherein at least one deflectable membrane acts as a valve to interrupt or separate fluid within a microfluidic channel having a cross-sectional dimension of about 500 micrometers. Exemplary microfluidic devices have been described by Hansen, supra, which are used to screen for conditions which cause protein crystals to form from protein solutions by free-interface diffusion (FID). In use, the devices of Hansen are loaded with a protein solution and a crystallization agent, typically in the form of a reagent solution, wherein each solution enters into individual chambers interconnected by a channel having a valve therein. Containment valves are then used to keep each of the solutions in their respective chamber as the valve located in the channel separating the chambers is opened to initiate diffusion between the chambers. In preferred devices of Hansen, the valves are actuated by changes in fluid pressure, for example either hydraulically or pneumatically. Therefore, a means for changing fluid pressure to each of the valve is helpful.
  • [0007]
    The invention provides, in one aspect, for a carrier that provides access to controlled fluid pressure. FIG. 2 depicts a perspective view of a preferred embodiment. The carrier in FIG. 2, which preferably has about a three inch square footprint and is preferably about one inch in height, is preferably made from a polymer, preferably acrylic. Other materials may be used depending on the nature of the experiments to be performed using the carrier, and the solvents that the carrier may be exposed to during use. For example, a carrier could be made from polypropylene to provide resistance to certain solvents such as acetone.
  • [0008]
    In FIG. 2, carrier 1 comprises housing or main block 2, a carrier lid or cover, not shown, which is used to close of the main block to form a chamber within carrier 1. Microfluidic device 3, which may be a microfluidic device or chip used to grow protein crystals, is held by connection block 4 through pins 5 and 6, which are preferably tubes in communication with flexible tubes 7 and 8, which in turn are connected to a source of controlled fluid pressure used to actuate valves within the microfluidic device. Microfluidic device 3, while attached to connection block 4, is inserted into main block 2 into a receiving portion 9, which may include at least one slot for retaining microfluidic device 3 while inserted within main block 2. Once fully inserted, microfluidic device 3 will be situated such that sample and reagent inlets 12 are within positioning guides 11 which are used to help a user to position a pipette tip into the microfluidic device for loading samples and reagents. Hydration control area 13 may further contain a source for hydration such as a sponge, a gel package, or a woven material such as a piece of cloth or a cotton ball/pad.
  • [0009]
    In use, a user would insert pins 5 and 6 of connection block 4 into microfluidic device 3, preferably in to ports located on the microfluidic device for communicating with valves therein. The microfluidic device would then be inserted into main block 2 to the extent that connection block 4 would contact, preferably mate, with receiving portion 9 of main block 2. Samples and regents could then be loaded into the microfluidic device before the attachment of a carrier lid or cover, not shown, to main block 2. Guides 10 and 11 would be used to help guide a pipette tip into the inlet port of the microfluidic device. During loading, it may be desirable to have at least one valve within the microfluidic device be activated so as to separate one or more fluid volumes contained within the microfluidic device. Once loaded, the user would then place carrier cover or lid, not shown, onto main block 2 to form a chamber housing the microfluidic device. A hydration control device, such as a sponge or pad may also be placed within the chamber in region 13, prior to attaching the cover. The sponge may be hydrated with water, buffer, a crystallization reagent, or a solvent. Alternatively, a desiccating material may added to remove moisture from the microfluidic device.
  • [0010]
    In preferred embodiments, an accumulator may be added to the carrier to provide a source of controlled fluid pressure. For example, an accumulator chamber may be affixed to the main block or the lid of the carrier, the accumulator chamber being in fluid communication with the connection block, and, therefore, with the microfluidic device. The advantage of having an “on-board” source of controlled fluid pressure is that the microfluidic device, if actuated by changes in fluid pressure, can be kept in an actuated state independent of an external source of fluid pressure, thus liberating the microfluidic device and carrier from an umbilical cord attached to that external source of fluid pressure. In preferred embodiments, the accumulator may further include a check valve for retaining fluid pressure within the accumulator. The accumulator may further include a gas pressurization inlet port, a liquid addition port, and a pressurized fluid outlet for communicating fluid pressure to the connection block.
  • [0011]
    While the present invention has been described herein with reference to particular embodiments thereof, a latitude of modification, various changes and substitutions are intended in the foregoing disclosure, and it will be appreciated that in some instances some features of the invention will be employed without a corresponding use of other features without departing from the scope of the invention as set forth. Therefore, many modifications may be made to adapt a particular situation or material to the teachings of the invention without departing from the essential scope and spirit of the present invention. It is intended that the invention not be limited to the particular embodiment disclosed as the best mode contemplated for carrying out this invention, but that the invention will include all embodiments and equivalents falling within the scope of the claims.
  • [0012]
    The entire contents of Appendix A, “Topaz™ Growth Chip, User Guide”, Fluidigm Corporation, So. San Francisco, Calif., 94080, which is s part of U.S. Provisional Application No. 60/525,245 (the application to which this application claims priority), filed Nov. 26, 2003, is expressly incorporated herein by reference in its entirety for all purposes. Appendix A is thus is to be construed as part of the present specification for all purposes.
Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US3570515 *Jun 19, 1969Mar 16, 1971Foxboro CoAminar stream cross-flow fluid diffusion logic gate
US3747628 *Feb 1, 1972Jul 24, 1973Philips CorpFluidic function module for use in a system for constructing fluidic circuits
US4046159 *Oct 7, 1975Sep 6, 1977Pegourie Jean PierrePneumatic logic circuits and their integrated circuits
US4119368 *Dec 22, 1976Oct 10, 1978Citizen Watch Co. Ltd.Elastomer display device
US4153855 *Dec 16, 1977May 8, 1979The United States Of America As Represented By The Secretary Of The ArmyMethod of making a plate having a pattern of microchannels
US4245673 *Feb 26, 1979Jan 20, 1981La Telemechanique ElectriquePneumatic logic circuit
US4434704 *Apr 14, 1980Mar 6, 1984Halliburton CompanyHydraulic digital stepper actuator
US4898582 *Aug 9, 1988Feb 6, 1990Pharmetrix CorporationPortable infusion device assembly
US4992312 *Mar 13, 1989Feb 12, 1991Dow Corning Wright CorporationMethods of forming permeation-resistant, silicone elastomer-containing composite laminates and devices produced thereby
US5085562 *Apr 4, 1990Feb 4, 1992Westonbridge International LimitedMicropump having a constant output
US5088515 *May 15, 1990Feb 18, 1992Kamen Dean LValve system with removable fluid interface
US5096388 *Mar 22, 1990Mar 17, 1992The Charles Stark Draper Laboratory, Inc.Microfabricated pump
US5126115 *Oct 30, 1990Jun 30, 1992Fujitsu LimitedProcess and apparatus for preparation of single crystal of biopolymer
US5164558 *Jul 5, 1991Nov 17, 1992Massachusetts Institute Of TechnologyMicromachined threshold pressure switch and method of manufacture
US5171132 *Dec 21, 1990Dec 15, 1992Seiko Epson CorporationTwo-valve thin plate micropump
US5224843 *Jun 12, 1990Jul 6, 1993Westonbridge International Ltd.Two valve micropump with improved outlet
US5259737 *Jul 2, 1991Nov 9, 1993Seiko Epson CorporationMicropump with valve structure
US5265327 *Sep 13, 1991Nov 30, 1993Faris Sadeg MMicrochannel plate technology
US5290240 *Feb 3, 1993Mar 1, 1994Pharmetrix CorporationElectrochemical controlled dispensing assembly and method for selective and controlled delivery of a dispensing fluid
US5336062 *Oct 20, 1992Aug 9, 1994Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V.Microminiaturized pump
US5346372 *Dec 3, 1993Sep 13, 1994Aisin Seiki Kabushiki KaishaFluid flow regulating device
US5375979 *Jun 16, 1993Dec 27, 1994Robert Bosch GmbhThermal micropump with values formed from silicon plates
US5376252 *Nov 10, 1992Dec 27, 1994Pharmacia Biosensor AbMicrofluidic structure and process for its manufacture
US5400741 *May 21, 1993Mar 28, 1995Medical Foundation Of Buffalo, Inc.Device for growing crystals
US5423287 *Nov 22, 1993Jun 13, 1995Nissan Motor Company, Ltd.Crystal growing cell
US5529465 *Jul 28, 1992Jun 25, 1996Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V.Micro-miniaturized, electrostatically driven diaphragm micropump
US5593130 *Sep 6, 1994Jan 14, 1997Pharmacia Biosensor AbValve, especially for fluid handling bodies with microflowchannels
US5642015 *May 1, 1995Jun 24, 1997The University Of British ColumbiaElastomeric micro electro mechanical systems
US5659171 *Oct 7, 1994Aug 19, 1997Northrop Grumman CorporationMicro-miniature diaphragm pump for the low pressure pumping of gases
US5660370 *Mar 7, 1996Aug 26, 1997Integrated Fludics, Inc.Valve with flexible sheet member and two port non-flexing backer member
US5681024 *May 21, 1994Oct 28, 1997Fraunhofer-Gesellschaft zur Forderung der angerwanden Forschung e.V.Microvalve
US5705018 *Dec 13, 1995Jan 6, 1998Hartley; Frank T.Micromachined peristaltic pump
US5759010 *Feb 8, 1996Jun 2, 1998Jacobs; Merrit NylesSealed cartridge to improve chemistry stability of test elements
US5759014 *Jan 12, 1995Jun 2, 1998Westonbridge International LimitedMicropump
US5775371 *Mar 8, 1995Jul 7, 1998Abbott LaboratoriesValve control
US5788468 *Nov 3, 1994Aug 4, 1998Memstek Products, LlcMicrofabricated fluidic devices
US5836750 *Oct 9, 1997Nov 17, 1998Honeywell Inc.Electrostatically actuated mesopump having a plurality of elementary cells
US5842787 *Oct 9, 1997Dec 1, 1998Caliper Technologies CorporationMicrofluidic systems incorporating varied channel dimensions
US5875817 *Aug 19, 1996Mar 2, 1999Ortech CorporationDigital gas metering system using tri-stable and bi-stable solenoids
US5876187 *Mar 9, 1995Mar 2, 1999University Of WashingtonMicropumps with fixed valves
US5932799 *Jul 21, 1997Aug 3, 1999Ysi IncorporatedMicrofluidic analyzer module
US5942443 *Jun 28, 1996Aug 24, 1999Caliper Technologies CorporationHigh throughput screening assay systems in microscale fluidic devices
US6007309 *Dec 8, 1997Dec 28, 1999Hartley; Frank T.Micromachined peristaltic pumps
US6043080 *Dec 11, 1998Mar 28, 2000Affymetrix, Inc.Integrated nucleic acid diagnostic device
US6123769 *Sep 15, 1999Sep 26, 2000Sumitomo Metal Industries, Ltd.Crystallization control method for organic compound and crystallization control solid-state component employed therefor
US6155282 *Jan 19, 1999Dec 5, 2000Triconex, IncorporatedTwo out of three voting solenoid arrangement
US6174365 *Jan 6, 1999Jan 16, 2001Sumitomo Metal Industries, Ltd.Apparatus for crystal growth and crystal growth method employing the same
US6296452 *Apr 28, 2000Oct 2, 2001Agilent Technologies, Inc.Microfluidic pumping
US6296673 *Jun 18, 1999Oct 2, 2001The Regents Of The University Of CaliforniaMethods and apparatus for performing array microcrystallizations
US6319476 *Mar 2, 1999Nov 20, 2001Perseptive Biosystems, Inc.Microfluidic connector
US6345502 *Nov 12, 1998Feb 12, 2002California Institute Of TechnologyMicromachined parylene membrane valve and pump
US6409832 *Mar 30, 2001Jun 25, 2002Micronics, Inc.Protein crystallization in microfluidic structures
US6767706 *Jun 5, 2001Jul 27, 2004California Institute Of TechnologyIntegrated active flux microfluidic devices and methods
US20010027745 *Mar 30, 2001Oct 11, 2001Weigl Bernhard H.Protein crystallization in microfluidic structures
US20020037499 *Jun 5, 2001Mar 28, 2002California Institute Of TechnologyIntegrated active flux microfluidic devices and methods
US20020192701 *Aug 2, 2002Dec 19, 2002Adey Nils B.Laminated microarray interface device
US20030061687 *Apr 5, 2002Apr 3, 2003California Institute Of Technology, A California CorporationHigh throughput screening of crystallization materials
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US7666360Feb 23, 2010Biotrove, Inc.Multi-through hole testing plate for high throughput screening
US7682565 *Dec 22, 2003Mar 23, 2010Biotrove, Inc.Assay apparatus and method using microfluidic arrays
US8016260Dec 7, 2007Sep 13, 2011Formulatrix, Inc.Metering assembly and method of dispensing fluid
US8029745Oct 4, 2011Massachusetts Institute Of TechnologySystems for filling a sample array by droplet dragging
US8030057Jan 26, 2005Oct 4, 2011President And Fellows Of Harvard CollegeFluid delivery system and method
US8100293Jan 23, 2009Jan 24, 2012Formulatrix, Inc.Microfluidic dispensing assembly
US8105554Jan 31, 2012Life Technologies CorporationNanoliter array loading
US8153059Jul 25, 2005Apr 10, 2012Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V.Chip-holder for a micro-fluidic chip
US8202492May 1, 2008Jun 19, 2012Opko Diagnostics, LlcFluidic connectors and microfluidic systems
US8221700Jul 17, 2012Opko Diagnostics, LlcStructures for controlling light interaction with microfluidic devices
US8222049Jul 17, 2012Opko Diagnostics, LlcFlow control in microfluidic systems
US8277753Aug 23, 2002Oct 2, 2012Life Technologies CorporationMicrofluidic transfer pin
US8389272Mar 5, 2013President And Fellows Of Harvard CollegeFluid delivery system and method
US8409527May 9, 2012Apr 2, 2013Opko Diagnostics, LlcFluidic connectors and microfluidic systems
US8475737May 9, 2012Jul 2, 2013Opko Diagnostics, LlcFluidic connectors and microfluidic systems
US8480975Jun 6, 2012Jul 9, 2013Opko Diagnostics, LlcStructures for controlling light interaction with microfluidic devices
US8545772Dec 23, 2011Oct 1, 2013Life Technologies CorporationNanoliter array loading
US8550298Feb 12, 2009Oct 8, 2013Formulatrix, Inc.Microfluidic dispensing assembly
US8567425Nov 24, 2010Oct 29, 2013Opko Diagnostics, LlcFluid mixing and delivery in microfluidic systems
US8580569Apr 15, 2011Nov 12, 2013Opko Diagnostics, LlcFeedback control in microfluidic systems
US8591829Dec 17, 2009Nov 26, 2013Opko Diagnostics, LlcReagent storage in microfluidic systems and related articles and methods
US8685340Apr 17, 2008Apr 1, 2014Life Technologies CorporationMicrofluidic transfer pin
US8697452Jun 8, 2012Apr 15, 2014Life Technologies CorporationThermal cycling assay apparatus and method
US8735055Dec 12, 2008May 27, 2014Gen-Probe IncorporatedMethods of concentrating an analyte
US8765062Mar 22, 2013Jul 1, 2014Opko Diagnostics, LlcSystems and devices for analysis of samples
US8765367Dec 12, 2008Jul 1, 2014Gen-Probe IncorporatedMethods and instruments for processing a sample in a multi-chambered receptacle
US8802029May 20, 2013Aug 12, 2014Opko Diagnostics, LlcStructures for controlling light interaction with microfluidic devices
US8802445Feb 12, 2013Aug 12, 2014Opko Diagnostics, LlcFluidic connectors and microfluidic systems
US8828654Jul 8, 2011Sep 9, 2014Gen-Probe IncorporatedMethods for manipulating liquid substances in multi-chambered receptacles
US8906618Oct 7, 2011Dec 9, 2014The Board Of Trustees Of The Leland Stanford Junior UniversityApparatus and methods for parallel processing of micro-volume liquid reactions
US8915259Sep 27, 2013Dec 23, 2014Opko Diagnostics, LlcFluid mixing and delivery in microfluidic systems
US8932523Apr 15, 2011Jan 13, 2015Opko Diagnostics, LlcSystems and devices for analysis of samples
US9075047Mar 21, 2014Jul 7, 2015Opko Diagnostics, LlcFluidic connectors and microfluidic systems
US9075051Apr 22, 2013Jul 7, 2015Opko Diagnostics, LlcFluid mixing and delivery in microfluidic systems
US9116124Oct 2, 2013Aug 25, 2015Opko Diagnostics, LlcFeedback control in microfluidic systems
US9116148Jan 31, 2013Aug 25, 2015President And Fellows Of Harvard CollegeFluid delivery system and method
US9205468Nov 30, 2010Dec 8, 2015Fluidigm CorporationMicrofluidic device regeneration
US9234888Nov 26, 2014Jan 12, 2016Opko Diagnostics, LlcFluidic connectors and microfluidic systems
US9255866Jul 30, 2014Feb 9, 2016Opko Diagnostics, LlcMixing of fluids in fluidic systems
US9266108Sep 30, 2013Feb 23, 2016Life Technologies CorporationNanoliter array loading
US9428800Mar 3, 2014Aug 30, 2016Life Technologies CorporationThermal cycling apparatus and method
US20020192716 *Aug 20, 2002Dec 19, 2002Volker SchellenbergerMulti-through hole testing plate for high throughput screening
US20060094108 *Sep 15, 2005May 4, 2006Karl YoderThermal cycler for microfluidic array assays
US20070003448 *Mar 11, 2005Jan 4, 2007Kanigan Tanya SNanoliter array loading
US20080038839 *Jan 26, 2005Feb 14, 2008Vincent LinderFluid Delivery System And Method
US20080273918 *May 1, 2008Nov 6, 2008Claros Diagnostics, Inc.Fluidic connectors and microfluidic systems
US20080299013 *Jul 25, 2005Dec 4, 2008Frakunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E. V.Chip-Holder for a Micro-Fluidic Chip
US20090136963 *Dec 12, 2008May 28, 2009Gen-Probe IncorporatedMethods of concentrating an analyte
US20090137029 *Dec 12, 2008May 28, 2009Gen-Probe IncorporatedMulti-Chambered Receptacles
US20090142771 *Dec 12, 2008Jun 4, 2009Gen-Probe IncorporatedMethods and Instruments for Processing a Sample in a Multi-Chambered Receptacle
US20090302190 *Oct 25, 2006Dec 10, 2009Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V.Chip holder, fluidic system and chip holder system
US20100196207 *Feb 2, 2010Aug 5, 2010David SteinmillerStructures for controlling light interaction with microfluidic devices
US20110120562 *May 26, 2011Claros Diagnostics, Inc.Fluid mixing and delivery in microfluidic systems
USD645971Sep 27, 2011Claros Diagnostics, Inc.Sample cassette
WO2007016931A1 *Jul 25, 2005Feb 15, 2007Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.Chip-holder for a micro-fluidic chip
WO2007115378A1 *Apr 11, 2007Oct 18, 2007Minifab (Australia) Pty LtdMicrofluidic package housing
Classifications
U.S. Classification422/400
International ClassificationB01L3/02, B01J19/00, B01L3/00, B01L9/00
Cooperative ClassificationB01L2400/0605, B01J2219/00891, B01J19/0093, B01L9/527, Y10T436/2575, Y10T117/1004, Y10T117/1064, B01J2219/0081, B01L2200/027, Y10T117/10, B01L2200/025, B01L2300/105, B01L2400/0487, Y10T436/25, Y10T117/1024, B01J2219/0095, B01L3/5027
European ClassificationB01L9/527, B01J19/00R
Legal Events
DateCodeEventDescription
Jan 26, 2005ASAssignment
Owner name: FLUIDIGM CORPORATION, CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:FACER, GEOFFREY RICHARD;NASSEF, HANY RAMEZ;REEL/FRAME:015606/0395;SIGNING DATES FROM 20050114 TO 20050118
Oct 1, 2007ASAssignment
Owner name: FLUIDIGM CORPORATION - A DELAWARE CORPORATION, CAL
Free format text: REINCORPORATION ASSIGNMENT;ASSIGNOR:FLUIDIGM CORPORATION - A CALIFORNIA CORPORATION;REEL/FRAME:019899/0313
Effective date: 20070928
Owner name: FLUIDIGM CORPORATION - A DELAWARE CORPORATION,CALI
Free format text: REINCORPORATION ASSIGNMENT;ASSIGNOR:FLUIDIGM CORPORATION - A CALIFORNIA CORPORATION;REEL/FRAME:019899/0313
Effective date: 20070928