|Publication number||US20050148882 A1|
|Application number||US 10/906,665|
|Publication date||Jul 7, 2005|
|Filing date||Mar 1, 2005|
|Priority date||Jan 6, 2004|
|Also published as||US7481772, US20050261594|
|Publication number||10906665, 906665, US 2005/0148882 A1, US 2005/148882 A1, US 20050148882 A1, US 20050148882A1, US 2005148882 A1, US 2005148882A1, US-A1-20050148882, US-A1-2005148882, US2005/0148882A1, US2005/148882A1, US20050148882 A1, US20050148882A1, US2005148882 A1, US2005148882A1|
|Inventors||Matthew Banet, Manuel Jaime|
|Original Assignee||Triage Wireless, Incc.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (93), Referenced by (19), Classifications (8), Legal Events (1)|
|External Links: USPTO, USPTO Assignment, Espacenet|
This application is a continuation-in-part application of U.S. patent application Ser. No. 10/752,198, filed on Jan. 6, 2004.
The present invention relates to medical devices for monitoring vital signs such as heart rate, pulse oximetry, and blood pressure, and using this information to condition a patient's response.
Pulse oximeters are medical devices featuring an optical module, typically worn on a patient's finger or ear lobe, and a processing module that analyzes data generated by the optical module. The optical module typically includes first and second light sources (e.g., light-emitting diodes, or LEDs) that transmit optical radiation at, respectively, red (λ˜630-670 nm) and infrared (λ˜800-1200 nm) wavelengths. The optical module also features a photodetector that detects radiation transmitted or reflected by an underlying artery. Typically the red and infrared LEDs sequentially emit radiation that is partially absorbed by blood flowing in the artery. The photodetector is synchronized with the LEDs to detect transmitted or reflected radiation. In response, the photodetector generates a separate radiation-induced signal for each wavelength. The signal, called a plethysmograph, varies in a time-dependent manner as each heartbeat varies the volume of arterial blood and hence the amount of transmitted or reflected radiation. A microprocessor in the pulse oximeter processes the relative absorption of red and infrared radiation to determine the oxygen saturation in the patient's blood. A number between 94%-100% is considered normal, while a value below 85% typically indicates the patient requires hospitalization. In addition, the microprocessor analyzes time-dependent features in the plethysmograph to determine the patient's heart rate.
Pulse oximeters work best when the appendage they attach to (e.g., a finger) is at rest. If the finger is moving, for example, the light source and photodetector within the optical module typically move relative to the hand. This generates ‘noise’ in the plethysmograph, which in turn can lead to motion-related artifacts in data describing pulse oximetry and heart rate. Ultimately this reduces the accuracy of the measurement. Various methods have been disclosed for using pulse oximeters to obtain arterial blood pressure values for a patient. One such method is disclosed in U.S. Pat. No. 5,140,990 to Jones et al., for a ‘Method Of Measuring Blood Pressure With a Photoplethysmograph’. The '990 patent discloses using a pulse oximeter with a calibrated auxiliary blood pressure monitor to generate a constant that is specific to a patient's blood pressure. Another method for using a pulse oximeter to measure blood pressure is disclosed in U.S. Pat. No. 6,616,613 to Goodman for a ‘Physiological Signal Monitoring System’. The '613 patent discloses processing a pulse oximetry signal in combination with information from a calibrating device to determine a patient's blood pressure.
The present invention provides a cuffless blood-pressure monitor that features a behavior modification system. The blood pressure monitor is typically worn on a patient's head and makes a transdermal, optical measurement of blood pressure, which it then sends to a processing component (e.g., a PDA). The processing component preferably features an embedded, short-range wireless transceiver and a software platform that displays, analyzes, and then transmits the information through a wireless network to an Internet-based system. This system generates an audio or visual alarm when the patient's blood pressure trends high, and thus the patient may modify their behavior through conditioned response. In addition, a medical professional can continuously monitor a patient's blood pressure during their day-to-day activities. Monitoring patients in this manner minimizes erroneous measurements due to ‘white coat syndrome’, increases the accuracy of a blood-pressure measurement and additionally allows patients to modify behavior to lower blood pressure while wearing the device.
The invention has many advantages. In particular, one aspect of the invention provides a system that continuously monitors a patient's blood pressure using a cuffless blood pressure monitor and an off-the-shelf mobile communication device. Information describing the blood pressure can be viewed using an Internet-based website, using a personal computer, or simply by viewing a display on the mobile device. Blood-pressure information measured continuously throughout the day provides a relatively comprehensive data set compared to that measured during isolated medical appointments. This approach identifies trends in a patient's blood pressure, such as a gradual increase or decrease, which allows for the patient to view and conditionally respond to high blood pressure through behavior modification such as breathing exercises. The monitor can also characterize the patient's heart rate and blood oxygen saturation using the same optical system for the blood-pressure measurement. This information can be wirelessly transmitted along with blood-pressure information and used to further diagnose the patient's cardiac condition. The monitor is small, easily worn by the patient during periods of exercise or day-to-day activities, and makes a non-invasive blood-pressure measurement in a matter of seconds. The resulting information has many uses for patients, medical professionals, hospitals, insurance companies, pharmaceutical agencies conducting clinical trials, and organizations for home-health monitoring.
In one aspect, the invention provides a system for measuring blood pressure from a patient that features: 1) an optical module configured to be worn on (or in) the patient's head that includes at least one optical source and a photodetector; 2) a calibration source configured to make a blood pressure measurement; and, 3) a processing module configured to: i) receive a first signal from the optical module; ii) receive a second signal from the calibration source; iii) process the first and second signals to generate a calibration table; and iv) receive a third signal from the optical module and compare it to the calibration table to determine the patient's blood pressure.
The preferred invention includes a response alert system designed to alert the patient when escalated vital signs reach dangerously harmful levels. The alert system alerts the patient when blood pressure levels reach dangerous levels caused by stress and anxiety. Each patient's blood pressure level parameters are set during the time of calibration by a physician.
In embodiments, the blood pressure monitor features a head-worn clip that includes the optical module (e.g., a photodetector and first and second LEDs that emit, respectively, red radiation and infrared radiation). The optical calibration source is typically a cuff-based blood pressure module that includes a cuff and a pump worn around the patient's arm. In other embodiments, the optical module includes a short-range wireless transmitter configured to send signals to the processing module, which in turn may include a matched short-range wireless receiver.
The short-range wireless transceiver preferably operates on a wireless protocol such as Bluetooth™, 802.15.4 or 802.11. The long-range wireless transmitter preferably transmits information over a terrestrial, satellite, or 802.11-based wireless network. Suitable networks include those operating at least one of the following protocols: CDMA, GSM, GPRS, Mobitex, DataTac, iDEN, and analogs and derivatives thereof.
In addition, the cuffless blood pressure-measuring device of the invention combines all the benefits of conventional cuff-based blood-pressure measuring devices without any of the obvious drawbacks (e.g., restrictive, uncomfortable cuffs). Its measurement is basically unobtrusive to the patient, and thus alleviates conditions, such as a poorly fitting cuff, that can erroneously affect a blood-pressure measurement. The device is small and makes a non-invasive blood-pressure measurement in a matter of seconds. An on-board or remote processor can analyze the time-dependent measurements to generate statistics on a patient's blood pressure (e.g., average pressures, standard deviation, beat-to-beat pressure variations) that are not available with conventional devices that only measure systolic and diastolic blood pressure.
These and other advantages of the invention will be apparent from the following detailed description and from the claims.
As shown in
Methods for processing the optical and electrical waveform to determine blood pressure are described in the following co-pending patent applications, the entire contents of which are incorporated by reference: 1) CUFFLESS BLOOD-PRESSURE MONITOR AND ACCOMPANYING WIRELESS, INTERNET-BASED SYSTEM (U.S. Ser. No. 10/709,015; filed Apr. 7, 2004); 2) CUFFLESS SYSTEM FOR MEASURING BLOOD PRESSURE (U.S. Ser. No. 10/709,014; filed Apr. 7, 2004); 3) CUFFLESS BLOOD PRESSURE MONITOR AND ACCOMPANYING WEB SERVICES INTERFACE (U.S. Ser. No. 10/810,237; filed Mar. 26, 2004); 4) VITAL-SIGN MONITOR FOR ATHLETIC APPLICATIONS (U.S. Ser. No.; filed Sep. 13, 2004); 5) CUFFLESS BLOOD PRESSURE MONITOR AND ACCOMPANYING WIRELESS MOBILE DEVICE (U.S. Ser. No. 10/967,511; filed Oct. 18, 2004); 6) BLOOD PRESSURE MONITORING DEVICE FEATURING A CALIBRATION-BASED ANALYSIS (U.S. Ser. No. 10/967,610; filed Oct. 18, 2004); 7) PERSONAL COMPUTER-BASED VITAL SIGN MONITOR (U.S. Ser. No. 10/906,342; filed Feb. 15, 2005); and 8) PATCH SENSOR FOR MEASURING BLOOD PRESSURE WITHOUT A CUFF (U.S. Ser. No. 10/906,315; filed Feb. 14, 2005).
The processing component 18 preferably supports a custom firmware application that displays and analyzes information for the ABPM 20. The firmware application is typically written to operate on a variety of mobile device operating systems including BREW, Palm OS, Java, Pocket PC, Windows CE, and Symbian. A more detailed explanation of the custom firmware application is disclosed in co-pending U.S. patent application Ser. No. 10/967511, filed on Oct. 18, 2004, for a CUFFLESS BLOOD-PRESSURE MONITOR AND ACCOMPANYING WIRELESS MOBILE DEVICE, the contents of which have been previously incorporated by reference.
Once the ABPM 20 is calibrated, the physician enters blood pressure limits into the personal computer 15. The blood pressure limits pass through the wired connection 34 to the processing component 19, where they are stored in memory. During an actual measurement, the processing module 19 compares the patient's blood pressure measured with the ABPM 20 to the blood pressure limits stored in memory to determine if the patient's blood pressure is trending high or low. If this is the case, the controller 19 initiates an audio and/or visual alert as described above.
During typical operation, the patient continuously wears the ABPM 20 for a period of time, ranging from a 1-2 days to weeks. For longer-term monitoring (e.g. several months), the patient may wear the ABPM 20 for shorter periods of time during the day. To view information sent from the ABPM 20, the patient or medical professional accesses a user interface hosted on the web site 66 through the Internet 67 from the secondary computer system 69. The system 53 may also include a call center, typically staffed with medical professionals such as doctors, nurses, or nurse practioners, whom access a care-provider interface hosted on the same website 66.
In an alternate embodiment, the host computer system 57 includes a web services interface 70 that sends information using an XML-based web services link to a secondary, web-based computer application 71. This application 71, for example, could be a data-management system operating at a hospital.
During operation, the cable 218 snaps into a plastic header 216 disposed on a top portion of the patch sensor 205. Both the cable 218 and header 216 include matched electrical leads that supply power and ground to the LEDs 210, 212, photodetector 214, and electrode 219. The cable 218 and header 216 additionally supply a high-frequency electrical signal to the electrode that helps generate the electrical waveform. When the patch sensor 205 is not measuring optical and electrical waveforms (e.g., when the patient is sleeping), the cable 218 unsnaps from the header 216, while the sensor 205 remains adhered to the patient's skin. In this way a single sensor can be used for several days. After use, the patient removes and then discards the sensor 205.
To measure blood pressure, heart rate, and pulse oximetry, the LEDs 210, 212 generate, respectively, red and infrared radiation that irradiates an underlying artery. Blood volume increases and then decreases as the heart pumps blood through the patient's artery. Blood cells within the blood absorb and transmit varying amounts of the red and infrared radiation depending the on the blood volume and how much oxygen binds to the cells' hemoglobin. The photodetector 214 detects a portion of the radiation that reflects off an underlying artery, and in response sends a radiation-induced photocurrent to an analog-to-digital converter embedded within the processing component. The analog-to-digital converter digitizes the photocurrent to generate a time-dependent optical waveform for each wavelength. In addition, the microprocessor analyzes waveforms generated at both red and infrared wavelengths, and compares a ratio of the relative absorption to a calibration table coded in its firmware to determine pulse oximetry. The microprocessor additionally analyzes the time-dependent properties of one of the optical waveforms to determine the patient's heart rate.
Concurrent with measurement of the optical waveform, the electrode 219 detects an electrical impulse from the patient's skin that the processing component processes to generate an electrical waveform. The electrical impulse is generated each time the patient's heart beats.
The patch sensor 205 preferably has a diameter, ‘D’, ranging from 0.5 centimeter (‘cm’) to 10 cm, more preferably from 1.5 cm to 3.0 cm, and most preferably 2.5 cm. The patch sensor 205 preferably has a thickness, ‘T’, ranging from 1.0 millimeter (“mm”) to 3 mm, more preferably from 1.0 mm to 1.5 mm, and most preferably 1.25 mm. The patch sensor 205 preferably includes a body composed of a polymeric material such as a neoprene rubber. The body is preferably colored to match a patient's skin color, and is preferably opaque to reduce the affects of ambient light. The body is preferably circular in shape, but can also be non-circular, e.g. an oval, square, rectangular, triangular or other shape.
In still other embodiments, the above-described system can receive inputs from other measurement devices, such as weight scales, glucometers, EKG/ECG monitors, cuff-based blood pressure monitors, dietary monitors, pedometers and other exercise monitors, and GPS systems.
Still other embodiments are within the scope of the following claims.
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|U.S. Classification||600/485, 128/903, 128/905|
|International Classification||A61B5/00, A61B5/02|
|Cooperative Classification||A61B5/0022, A61B5/002|
|Mar 1, 2005||AS||Assignment|
Owner name: TRIAGE WIRELESS, INC., CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MANUEL, JAIME EDUARDO;BANET, MATTHEW JOHN;REEL/FRAME:015713/0659
Effective date: 20050228