|Publication number||US20050216077 A1|
|Application number||US 11/132,788|
|Publication date||Sep 29, 2005|
|Filing date||May 18, 2005|
|Priority date||Jan 30, 2002|
|Also published as||CA2469460A1, CA2469460C, CA2760865A1, EP1482869A2, EP1482869A4, US6976995, US7828842, US8974525, US20030144697, US20080140191, US20080319542, US20110035000, US20150173901, WO2003063735A2, WO2003063735A3|
|Publication number||11132788, 132788, US 2005/0216077 A1, US 2005/216077 A1, US 20050216077 A1, US 20050216077A1, US 2005216077 A1, US 2005216077A1, US-A1-20050216077, US-A1-2005216077, US2005/0216077A1, US2005/216077A1, US20050216077 A1, US20050216077A1, US2005216077 A1, US2005216077A1|
|Inventors||Mark Mathis, Gregory Nieminen, David Reuter|
|Original Assignee||Mathis Mark L, Nieminen Gregory D, Reuter David G|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (99), Referenced by (34), Classifications (11), Legal Events (1)|
|External Links: USPTO, USPTO Assignment, Espacenet|
This application is a continuation application of Ser. No. 10/066,426 filed Jan. 30, 2002, which is incorporated herein by reference in its entirety and to which application we claim priority under 35 USC § 120.
The present invention generally relates to a device and method for treating dilated cardiomyopathy of a heart. The present invention more particularly relates to a device and method for reshaping the mitral valve annulus.
The human heart generally includes four valves. Of these valves, a most critical one is known as the mitral valve. The mitral valve is located in the left atrial ventricular opening between the left atrium and left ventricle. The mitral valve is intended to prevent regurgitation of blood from the left ventricle into the left atrium when the left ventricle contracts. In preventing blood regurgitation the mitral valve must be able to withstand considerable back pressure as the left ventricle contracts.
The valve cusps of the mitral valve are anchored to muscular wall of the heart by delicate but strong fibrous cords in order to support the cusps during left ventricular contraction. In a healthy mitral valve, the geometry of the mitral valve ensures that the cusps overlie each other to preclude regurgitation of the blood during left ventricular contraction.
The normal functioning of the mitral valve in preventing regurgitation can be impaired by dilated cardiomyopathy caused by disease or certain natural defects. For example, certain diseases may cause dilation of the mitral valve annulus. This can result in deformation of the mitral valve geometry to cause ineffective closure of the mitral valve during left ventricular contraction. Such ineffective closure results in leakage through the mitral valve and regurgitation. Diseases such as bacterial inflammations of the heart or heart failure can cause the aforementioned distortion or dilation of the mitral valve annulus. Needless to say, mitral valve regurgitation must not go uncorrected.
One method of repairing a mitral valve having impaired function is to completely replace the valve. This method has been found to be particularly suitable for replacing a mitral valve when one of the cusps has been severely damaged or deformed. While the replacement of the entire valve eliminates the immediate problem associated with a dilated mitral valve annulus, presently available prosthetic heart valves do not possess the same durability as natural heart valves.
Various other surgical procedures have been developed to correct the deformation of the mitral valve annulus and thus retain the intact natural heart valve function. These surgical techniques involve repairing the shape of the dilated or deformed valve annulus. Such techniques, generally known as annuloplasty, require surgically restricting the valve annulus to minimize dilation. Here, a prosthesis is typically sutured about the base of the valve leaflets to reshape the valve annulus and restrict the movement of the valve annulus during the opening and closing of the mitral valve.
Many different types of prostheses have been developed for use in such surgery. In general, prostheses are annular or partially annular shaped members which fit about the base of the valve annulus. The annular or partially annular shaped members may be formed from a rigid material, such as a metal, or from a flexible material.
While the prior art methods mentioned above have been able to achieve some success in treating mitral regurgitation, they have not been without problems and potential adverse consequences. For example, these procedures require open heart surgery. Such procedures are expensive, are extremely invasive requiring considerable recovery time, and pose the concomitant mortality risks associated with such procedures. Moreover, such open heart procedures are particularly stressful on patients with a comprised cardiac condition. Given these factors, such procedures are often reserved as a last resort and hence are employed late in the mitral regurgitation progression. Further, the effectiveness of such procedures is difficult to assess during the procedure and may not be known until a much later time. Hence, the ability to make adjustments to or changes in the prostheses to obtain optimum effectiveness is extremely limited. Later corrections, if made at all, require still another open heart surgery.
An improved therapy to treat mitral regurgitation without resorting to open heart surgery has recently been proposed. This is rendered possible by the realization that the coronary sinus of a heart is near to and at least partially encircles the mitral valve annulus and then extends into a venous system including the great cardiac vein. As used herein, the term “coronary sinus” is meant to refer to not only the coronary sinus itself but in addition, the venous system associated with the coronary sinus including the great cardiac vein. The therapy contemplates the use of a device introduced into the coronary sinus to reshape and advantageously affect the geometry of the mitral valve annulus.
The device includes a resilient member having a cross sectional dimension for being received within the coronary sinus of the heart and a longitudinal dimension having an unstressed arched configuration when placed in the coronary sinus. The device partially encircles and exerts an inward pressure on the mitral valve. The inward pressure constricts the mitral valve annulus, or at least a portion of it, to essentially restore the mitral valve geometry. This promotes effective valve sealing action and eliminates mitral regurgitation.
The device may be implanted in the coronary sinus using only percutaneous techniques similar to the techniques used to implant cardiac leads such as pacemaker leads. One proposed system for implanting the device includes an elongated introducer configured for being releasably coupled to the device. The introducer is preferably flexible to permit it to advance the device into the heart and into the coronary sinus through the coronary sinus ostium. To promote guidance, an elongated sheath is first advanced into the coronary sinus. Then, the device and introducer are moved through a lumen of the sheath until the device is in position within the coronary sinus. Because the device is formed of resilient material, it conforms to the curvatures of the lumen as it is advanced through the sheath. The sheath is then partially retracted to permit the device to assume its unstressed arched configuration. Once the device is properly positioned, the introducer is then decoupled from the device and retracted through the sheath. The procedure is then completed by the retraction of the sheath. As a result, the device is left within the coronary sinus to exert the inward pressure on the mitral valve to restore mitral valve geometry.
The foregoing therapy has many advantages over the traditional open heart surgery approach. Since the device, system and method may be employed in a comparatively noninvasive procedure, mitral valve regurgitation may be treated at an early stage in the mitral regurgitation progression. Further, the device may be placed with relative ease by any minimally invasive cardiologist. Still further, since the heart remains completely intact throughout the procedure, the effectiveness of the procedure may be readily determined. Moreover, should adjustments be deemed desirable, such adjustments may be made during the procedure and before the patient is sent to recovery.
Another approach to treat mitral regurgitation with a device in the coronary sinus is based upon the observation that the application of a localized force against a discrete portion of the mitral valve annulus can terminate mitral regurgitation. This suggests that mitral valve dilation may be localized and nonuniform. Hence, the device applies a force to one or more discrete portions of the atrial wall of the coronary sinus to provide localized mitral valve annulus reshaping instead of generalized reshaping of the mitral valve annulus. Such localized therapy would have all the benefits of the generalized therapy. In addition, a localized therapy device may be easier to implant and adjust.
A still further approach to treat mitral regurgitation from the coronary sinus of the heart contemplates a device having a first anchor configured to be positioned within and fixed to the coronary sinus of the heart adjacent the mitral valve annulus within the heart, a cable fixed to the first anchor and extending proximally from the first anchor within the heart, a second anchor configured to be positioned in and fixed in the heart proximal to the first anchor and arranged to slidingly receive the cable, and a lock that locks the cable on the second anchor. When the first and second anchors are fixed within the heart, the cable may be drawn proximally and locked on the second anchor. The geometry of the mitral valve is thereby affected. This approach provides flexibility in that the second anchor may be positioned and fixed in the coronary sinus or alternatively, the second anchor may be positioned and fixed in the right atrium. This approach further allows adjustments in the cable tension after implant. The present invention provides a still further alternative for treating mitral regurgitation with a device placed in the coronary sinus adjacent to the mitral valve annulus.
The present invention provides a device that affects mitral valve annulus geometry of a heart. The device includes a first anchor configured to be positioned within and anchored to the coronary sinus of the heart adjacent the mitral valve annulus within the heart, and a second anchor configured to be positioned within the heart proximal to the first anchor and adjacent the mitral valve annulus within the heart. The device further includes a connecting member having a fixed length permanently attached to the first and second anchors. As a result, when the first and second anchors are within the heart with the first anchor anchored in the coronary sinus, the second anchor may be displaced proximally to affect the geometry of the mitral valve annulus and released to maintain the effect on the mitral valve geometry. The second anchor may be configured, when deployed, to anchor against distal movement but be moveable proximally to permit the second anchor to be displaced proximally within the coronary sinus.
The first anchor and the second anchor are preferably self-deploying upon release in the coronary sinus or may be deployable after placement. Further, the connecting member, in being of fixed length, has a maximum extended length and as such may be a rigid member, have an initial arcuate configuration, include a spring, having a maximum length or be flexible but not stretchable.
The present invention further provides a device for affecting mitral valve annulus geometry of a heart. The device includes first anchor means for anchoring in the coronary sinus of the heart adjacent the mitral valve annulus, and second anchor means for being deployed within the heart proximal to the first anchor means and adjacent the mitral valve annulus, and connecting means having a fixed length and permanently connecting the first anchor means to the second anchor means. As a result, when the first and second anchor means are within the heart with the first anchor means anchored in the coronary sinus, the second anchor means may be displaced proximally for cooperating with the first anchor means and the connecting means for affecting the geometry of the mitral valve annulus and released for maintaining the effect on the mitral valve geometry.
The invention further provides a system that affects mitral valve annulus geometry of a heart. The system includes a mitral valve device including a first anchor configured to be positioned within and anchored to the coronary sinus of the heart adjacent the mitral valve annulus within the heart, a second anchor configured to be positioned within the heart proximal to the first anchor and adjacent the mitral valve annulus within the heart, and a connecting member having a fixed length permanently attached to the first and second anchors.
The system further includes a catheter having a distal end, a proximal end and a lumen that receives the device, the catheter being guidable into the coronary sinus adjacent to the mitral valve annulus and deploying the first and second anchors of the device within the coronary sinus adjacent to the mitral valve annulus, and a tether releasably coupled to the second anchor and extending proximally through the lumen and out of the catheter proximal end. As a result, when the first anchor is deployed by the catheter in the coronary sinus, the second anchor may be displaced proximally by proximally pulling on the tether to affect the geometry of the mitral valve annulus and thereafter released for deployment to maintain the effect on the mitral valve geometry.
The present invention further provides a method of affecting mitral valve annulus geometry in a heart. The method includes the steps of fixing a first anchor within the coronary sinus of the heart adjacent to the mitral valve annulus, positioning a second anchor within the coronary sinus adjacent to the mitral valve annulus and proximal to the first anchor, fixing a fixed length connecting member between the first anchor and the second anchor, displacing the second anchor proximally to affect the geometry of the mitral valve annulus, and releasing the second anchor from further proximal displacement to maintain the effect on the mitral valve geometry.
The present invention further provides a device that affects mitral valve annulus geometry of a heart. The device includes a first anchor configured to be positioned within and anchored to the coronary sinus of the heart adjacent the mitral valve annulus within the heart, a second anchor configured to be positioned within the heart proximal to the first anchor and adjacent the mitral valve annulus within the heart, and a connecting member attached between the first and second anchors. At least one of the first and second anchors anchoring against movement in a first direction and being moveable in a second direction opposite the first direction.
The at least one anchor may be the first anchor wherein the first direction is a proximal direction and wherein the second direction is a distal direction. The at least one anchor may be the second anchor wherein the first direction is a distal direction and wherein the second direction is a proximal direction. In a preferred embodiment, the first anchor anchors against movement in a proximal direction and is moveable in a distal direction and the second anchor anchors against movement in the distal direction and is moveable in the proximal direction.
The invention still further provides a device that affects mitral valve annulus geometry of a heart and which permits a cardiac lead to be implanted in the left side of the heart. The device includes a first anchor configured to be positioned within and anchored to the coronary sinus of the heart adjacent the mitral valve annulus within the heart, a second anchor configured to be positioned within the heart proximal to the first anchor and adjacent the mitral valve annulus within the heart, and a connecting member attached between the first and second anchors. The first anchor is configured to occupy less than all of the coronary sinus to permit a cardiac lead to be passed by the first anchor.
The first anchor may include a loop through which the cardiac lead may be passed. The second anchor may be positionable within the coronary sinus and be configured to occupy less than all of the coronary sinus to permit the cardiac lead to be passed by the second anchor. The second anchor may also include a loop through which the cardiac lead may be passed.
The features of the present invention which are believed to be novel are set forth with particularity in the appended claims. The invention, together with further aspects and advantages thereof, may best be understood by making reference to the following description taken in conjunction with the accompanying drawings, in the several figures of which like reference numerals identify identical elements, and wherein:
Referring now to
The mitral valve 12 includes an anterior cusp 16, a posterior cusp 18 and an annulus 20. The annulus encircles the cusps 16 and 18 and maintains their spacing to provide a complete closure during a left ventricular contraction. As is well known, the coronary sinus 14 partially encircles the mitral valve 12 adjacent to the mitral valve annulus 20. As is also known, the coronary sinus is part of the venous system of the heart and extends along the AV groove between the left atrium and the left ventricle. This places the coronary sinus essentially within the same plane as the mitral valve annulus making the coronary sinus available for placement of the mitral valve therapy device of the present invention therein.
The first anchor 32 is located at the distal end of the device 30. The anchor 32 is hook-shaped so as to be self-deployable when released in the coronary sinus 14. More specifically, the device 30 may be formed of most any biocompatible material such as stainless steel, Nitinol, a nickel/titanium alloy of the type well known in the art having shape memory or plastic. The hook-shaped configuration of the anchor 32 thus expands when released to wedge against the inner wall of the coronary sinus 14 for anchoring or fixing the anchor 32 against at least proximal movement. The anchor 32 may however allow distal movement. Preferably, the anchor 32 is positioned just proximally to the crossover point 19 of the coronary sinus 14 and a circumflex artery 17.
The connecting member 34, by being formed of Nitinol, is relatively rigid and is predisposed to have an arcuate configuration to generally correspond to the shape of the mitral valve annulus 20. The connecting member 34 is of a fixed length and is permanently attached to the first and second anchors 32 and 36. Here it will be noted that the second anchor is positioned within the coronary sinus just distal to the ostium 21 of the coronary sinus 14. The second anchor 36 may have a similar hook-shaped configuration and is also preferably self-expanding to be self-deployable. The hook-shape of the anchor 36 anchors or fixes the anchor 36 against distal movement but permits the anchor to be pulled proximally. This is a particularly significant aspect of the device 30 because it permits the device to be adjusted after the anchors 32 and 36 are first deployed.
When the device 30 is deployed as shown in
The connecting member 34 may be provided with a covering (not shown). The covering may preferably be formed of a compressible material to serve to cushion the forces of the connecting member applied against the inner wall of the coronary sinus 14.
As will be noted in
As shown in
As may now be further seen in
In accordance with the present invention, the device 30 may be deployed in a slightly different manner as described above. Here, the first anchor 32 may be deployed as described above and the second anchor 36 left in the catheter 52 as it is moved proximally. When the second anchor 36 reaches a desired position, the catheter 52 may then be pulled back to release and deploy the second anchor 36. As a result, in accordance with this alternative embodiment, the second anchor, when deployed, may anchor against both distal and proximal movement.
The first and second anchors 72 and 76 are again configured so that when they are released, they self-expand, to wedge against the inner wall of the coronary sinus 14. Again, the first anchor resists proximal movement and the second anchor 76 resists distal movement. In all other respects, the device 70 may be identical to and deployed in the same manner as the device 30.
Implantable cardiac stimulation devices are well known in the art. Such devices may include, for example, implantable cardiac pacemakers and defibrillators. The devices are generally implanted in a pectoral region of the chest beneath the skin of a patient within what is known as a subcutaneous pocket. The implantable devices generally function in association with one or more electrode carrying leads which are implanted within the heart. The electrodes are usually positioned within the right side of the heart, either within the right ventricle or right atrium, or both, for making electrical contact with their respective heart chamber. Conductors within the leads and a proximal connector carried by the leads couple the electrodes to the device to enable the device to sense cardiac electrical activity and deliver the desired therapy.
Traditionally, therapy delivery had been limited to the venous, or right side of the heart. The reason for this is that implanted electrodes can cause blood clot formation in some patients. If a blood clot were released arterially from the left heart, as for example the left ventricle, it could pass directly to the brain potentially resulting in a paralyzing or fatal stroke. However, a blood clot released from the right heart, as from the right ventricle, would pass into the lungs where the filtering action of the lungs would prevent a fatal or debilitating embolism in the brain.
Recently, new lead structures and methods have been proposed and even practiced for delivering cardiac rhythm management therapy to the left heart. These lead structures and methods avoid direct electrode placement within the left atrium and left ventricle of the heart by lead implantation within the coronary sinus of the heart. As previously mentioned, the phrase “coronary sinus” refers to not only the coronary sinus itself but in addition, the venous system associated with the coronary sinus including the great cardiac vein.
It has been demonstrated that electrodes placed in the coronary sinus region of the heart may be used for left atrial pacing, left ventricular pacing, or cardioversion and defibrillation. These advancements enable implantable cardiac stimulation devices to address the needs of a patient population with left ventricular dysfunction and/or congestive heart failure which would benefit from left heart side pacing, either alone or in conjunction with right heart side pacing (bi-chamber pacing), and/or defibrillation.
Even though the device of the present invention is implantable in the coronary sinus of the heart, it is configured in accordance with further aspects of the present invention to permit a cardiac lead to pass through the coronary sinus for functioning as described above. To that end, and as best seen in
More specifically, the anchors 32 and 36 take the form of loops 33 and 35 respectively which are then bent backwards on the device to form the previously referred to hook-shapes for self-deployment. The loops 33 and 35 thus permit the cardiac lead 80 to be passed therethrough for implant in the left heart. This is particularly desirable because many patients suffering from mitral regurgitation may also be candidates for left heart cardiac rhythm management therapy.
While particular embodiments of the present invention have been shown and described, modifications may be made, and it is therefore intended in the appended claims to cover all such changes and modifications which fall within the true spirit and scope of the invention as defined by the appended claims.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3786806 *||Nov 22, 1972||Jan 22, 1974||F Alicandri||Thermoconstrictive surgical appliance|
|US3890977 *||Mar 1, 1974||Jun 24, 1975||Bruce C Wilson||Kinetic memory electrodes, catheters and cannulae|
|US4588395 *||Oct 28, 1980||May 13, 1986||Lemelson Jerome H||Catheter and method|
|US4830023 *||Nov 27, 1987||May 16, 1989||Medi-Tech, Incorporated||Medical guidewire|
|US5099838 *||Dec 15, 1988||Mar 31, 1992||Medtronic, Inc.||Endocardial defibrillation electrode system|
|US5104404 *||Jun 20, 1991||Apr 14, 1992||Medtronic, Inc.||Articulated stent|
|US5507295 *||Jun 29, 1993||Apr 16, 1996||British Technology Group Limited||Medical devices|
|US5507802 *||Oct 7, 1994||Apr 16, 1996||Cardiac Pathways Corporation||Method of mapping and/or ablation using a catheter having a tip with fixation means|
|US5514161 *||Apr 4, 1995||May 7, 1996||Ela Medical S.A.||Methods and apparatus for controlling atrial stimulation in a double atrial triple chamber cardiac pacemaker|
|US5601600 *||Sep 8, 1995||Feb 11, 1997||Conceptus, Inc.||Endoluminal coil delivery system having a mechanical release mechanism|
|US5617854 *||Jun 22, 1994||Apr 8, 1997||Munsif; Anand||Shaped catheter device and method|
|US5733325 *||May 6, 1996||Mar 31, 1998||C. R. Bard, Inc.||Non-migrating vascular prosthesis and minimally invasive placement system|
|US5741297 *||Aug 28, 1996||Apr 21, 1998||Simon; Morris||Daisy occluder and method for septal defect repair|
|US5752969 *||Jun 16, 1994||May 19, 1998||Sofamor S.N.C.||Instrument for the surgical treatment of an intervertebral disc by the anterior route|
|US5871501 *||Jan 12, 1998||Feb 16, 1999||Datascope Investment Corp.||Guide wire with releasable barb anchor|
|US5891193 *||Apr 11, 1997||Apr 6, 1999||C.R. Bard, Inc.||Non-migrating vascular prosthesis and minimally invasive placement system therefor|
|US5895391 *||Sep 27, 1996||Apr 20, 1999||Target Therapeutics, Inc.||Ball lock joint and introducer for vaso-occlusive member|
|US5899882 *||Apr 4, 1996||May 4, 1999||Novoste Corporation||Catheter apparatus for radiation treatment of a desired area in the vascular system of a patient|
|US5908404 *||Mar 3, 1998||Jun 1, 1999||Elliott; James B.||Methods for inserting an implant|
|US6015402 *||Jun 4, 1998||Jan 18, 2000||Sahota; Harvinder||Wire perfusion catheter|
|US6022371 *||Jul 21, 1998||Feb 8, 2000||Scimed Life Systems, Inc.||Locking stent|
|US6027517 *||May 13, 1997||Feb 22, 2000||Radiance Medical Systems, Inc.||Fixed focal balloon for interactive angioplasty and stent implantation catheter with focalized balloon|
|US6045497 *||Jul 29, 1998||Apr 4, 2000||Myocor, Inc.||Heart wall tension reduction apparatus and method|
|US6053900 *||Oct 7, 1998||Apr 25, 2000||Brown; Joe E.||Apparatus and method for delivering diagnostic and therapeutic agents intravascularly|
|US6059775 *||Dec 31, 1997||May 9, 2000||Nielsen; James M.||Multifocal corneal sculpturing|
|US6077295 *||Jul 15, 1996||Jun 20, 2000||Advanced Cardiovascular Systems, Inc.||Self-expanding stent delivery system|
|US6077297 *||Jan 12, 1998||Jun 20, 2000||C. R. Bard, Inc.||Non-migrating vascular prosthesis and minimally invasive placement system therefor|
|US6080182 *||Dec 19, 1997||Jun 27, 2000||Gore Enterprise Holdings, Inc.||Self-expanding defect closure device and method of making and using|
|US6171320 *||Oct 7, 1997||Jan 9, 2001||Niti Alloys Technologies Ltd.||Surgical clip|
|US6183512 *||Apr 16, 1999||Feb 6, 2001||Edwards Lifesciences Corporation||Flexible annuloplasty system|
|US6190406 *||Feb 2, 1999||Feb 20, 2001||Nitinal Development Corporation||Intravascular stent having tapered struts|
|US6200336 *||Jun 2, 1999||Mar 13, 2001||Cook Incorporated||Multiple-sided intraluminal medical device|
|US6210432 *||Jun 30, 1999||Apr 3, 2001||Jan Otto Solem||Device and method for treatment of mitral insufficiency|
|US6228098 *||Jul 10, 1998||May 8, 2001||General Surgical Innovations, Inc.||Apparatus and method for surgical fastening|
|US6334864 *||May 17, 2000||Jan 1, 2002||Aga Medical Corp.||Alignment member for delivering a non-symmetric device with a predefined orientation|
|US6342067 *||Jan 9, 1998||Jan 29, 2002||Nitinol Development Corporation||Intravascular stent having curved bridges for connecting adjacent hoops|
|US6345198 *||Jul 29, 1999||Feb 5, 2002||Pacesetter, Inc.||Implantable stimulation system for providing dual bipolar sensing using an electrode positioned in proximity to the tricuspid valve and programmable polarity|
|US6352553 *||Jul 18, 1997||Mar 5, 2002||Gore Enterprise Holdings, Inc.||Stent-graft deployment apparatus and method|
|US6352561 *||Dec 23, 1996||Mar 5, 2002||W. L. Gore & Associates||Implant deployment apparatus|
|US6358195 *||Mar 9, 2000||Mar 19, 2002||Neoseed Technology Llc||Method and apparatus for loading radioactive seeds into brachytherapy needles|
|US6395017 *||Nov 15, 1996||May 28, 2002||C. R. Bard, Inc.||Endoprosthesis delivery catheter with sequential stage control|
|US6503271 *||Dec 7, 2000||Jan 7, 2003||Cordis Corporation||Intravascular device with improved radiopacity|
|US6537314 *||Jan 30, 2001||Mar 25, 2003||Ev3 Santa Rosa, Inc.||Percutaneous mitral annuloplasty and cardiac reinforcement|
|US6556873 *||Nov 29, 1999||Apr 29, 2003||Medtronic, Inc.||Medical electrical lead having variable bending stiffness|
|US6562066 *||Mar 2, 2001||May 13, 2003||Eric C. Martin||Stent for arterialization of the coronary sinus and retrograde perfusion of the myocardium|
|US6562067 *||Jun 8, 2001||May 13, 2003||Cordis Corporation||Stent with interlocking elements|
|US6565221 *||Nov 21, 2001||May 20, 2003||Buehler Motor Gmbh||Adjusting device for a motor vehicle mirror with contactor|
|US6569198 *||Mar 30, 2001||May 27, 2003||Richard A. Wilson||Mitral or tricuspid valve annuloplasty prosthetic device|
|US6676702 *||May 14, 2001||Jan 13, 2004||Cardiac Dimensions, Inc.||Mitral valve therapy assembly and method|
|US6689164 *||Oct 10, 2000||Feb 10, 2004||Jacques Seguin||Annuloplasty device for use in minimally invasive procedure|
|US6709425 *||Jan 31, 2001||Mar 23, 2004||C. R. Bard, Inc.||Vascular inducing implants|
|US6716158 *||Sep 6, 2002||Apr 6, 2004||Mardil, Inc.||Method and apparatus for external stabilization of the heart|
|US6718985 *||May 25, 2001||Apr 13, 2004||Edwin J. Hlavka||Method and apparatus for catheter-based annuloplasty using local plications|
|US6721598 *||Aug 31, 2001||Apr 13, 2004||Pacesetter, Inc.||Coronary sinus cardiac lead for stimulating and sensing in the right and left heart and system|
|US6723784 *||Apr 10, 2001||Apr 20, 2004||Seiko Epson Corporation||Coating liquid, and image recording method and recording using same|
|US6733521 *||Apr 11, 2001||May 11, 2004||Trivascular, Inc.||Delivery system and method for endovascular graft|
|US6881220 *||Aug 8, 2003||Apr 19, 2005||Bard Peripheral Vascular, Inc.||Method of recapturing a stent|
|US6899734 *||Mar 23, 2001||May 31, 2005||Howmedica Osteonics Corp.||Modular implant for fusing adjacent bone structure|
|US7175653 *||May 3, 2001||Feb 13, 2007||Xtent Medical Inc.||Selectively expandable and releasable stent|
|US8172898 *||Mar 8, 2010||May 8, 2012||Cardiac Dimensions, Inc.||Device and method for modifying the shape of a body organ|
|US20020016628 *||Oct 1, 2001||Feb 7, 2002||Langberg Jonathan J.||Percutaneous mitral annuloplasty with hemodynamic monitoring|
|US20020042621 *||Jun 22, 2001||Apr 11, 2002||Liddicoat John R.||Automated annular plication for mitral valve repair|
|US20020042651 *||Jun 29, 2001||Apr 11, 2002||Liddicoat John R.||Method and apparatus for performing a procedure on a cardiac valve|
|US20020049468 *||Jun 29, 2001||Apr 25, 2002||Streeter Richard B.||Intravascular filter with debris entrapment mechanism|
|US20020055774 *||Sep 7, 2001||May 9, 2002||Liddicoat John R.||Fixation band for affixing a prosthetic heart valve to tissue|
|US20020065554 *||Oct 25, 2001||May 30, 2002||Streeter Richard B.||Mitral shield|
|US20030018358 *||Jul 3, 2002||Jan 23, 2003||Vahid Saadat||Apparatus and methods for treating tissue|
|US20030040771 *||Sep 16, 2002||Feb 27, 2003||Hideki Hyodoh||Methods for creating woven devices|
|US20030069636 *||Nov 26, 2002||Apr 10, 2003||Solem Jan Otto||Method for treatment of mitral insufficiency|
|US20030078465 *||Oct 11, 2002||Apr 24, 2003||Suresh Pai||Systems for heart treatment|
|US20030078654 *||Aug 14, 2002||Apr 24, 2003||Taylor Daniel C.||Method and apparatus for improving mitral valve function|
|US20030083538 *||Nov 1, 2001||May 1, 2003||Cardiac Dimensions, Inc.||Focused compression mitral valve device and method|
|US20030083613 *||Dec 6, 2002||May 1, 2003||Schaer Alan K.||Catheter positioning system|
|US20030088305 *||Oct 25, 2002||May 8, 2003||Cook Incorporated||Prostheses for curved lumens|
|US20030093148 *||Oct 9, 2002||May 15, 2003||Bolling Steven F.||Mitral valve annuloplasty ring for molding left ventricle geometry|
|US20040010305 *||May 2, 2003||Jan 15, 2004||Cardiac Dimensions, Inc.||Device and method for modifying the shape of a body organ|
|US20040019377 *||Jan 14, 2003||Jan 29, 2004||Taylor Daniel C.||Method and apparatus for reducing mitral regurgitation|
|US20040039443 *||Dec 24, 2002||Feb 26, 2004||Solem Jan Otto||Method and device for treatment of mitral insufficiency|
|US20040073302 *||May 27, 2003||Apr 15, 2004||Jonathan Rourke||Method and apparatus for improving mitral valve function|
|US20040098116 *||Nov 15, 2002||May 20, 2004||Callas Peter L.||Valve annulus constriction apparatus and method|
|US20040102839 *||Jun 26, 2003||May 27, 2004||Cohn William E.||Method and apparatus for improving mitral valve function|
|US20040102840 *||Nov 13, 2003||May 27, 2004||Solem Jan Otto||Method and device for treatment of mitral insufficiency|
|US20050004667 *||May 10, 2004||Jan 6, 2005||Cardiac Dimensions, Inc. A Delaware Corporation||Device, system and method to affect the mitral valve annulus of a heart|
|US20050010240 *||May 5, 2004||Jan 13, 2005||Cardiac Dimensions Inc., A Washington Corporation||Device and method for modifying the shape of a body organ|
|US20050021121 *||Jun 3, 2004||Jan 27, 2005||Cardiac Dimensions, Inc., A Delaware Corporation||Adjustable height focal tissue deflector|
|US20050027351 *||Dec 19, 2003||Feb 3, 2005||Cardiac Dimensions, Inc. A Washington Corporation||Mitral valve regurgitation treatment device and method|
|US20050027353 *||Aug 24, 2004||Feb 3, 2005||Alferness Clifton A.||Mitral valve therapy device, system and method|
|US20050033419 *||Aug 24, 2004||Feb 10, 2005||Alferness Clifton A.||Mitral valve therapy device, system and method|
|US20050038507 *||Aug 24, 2004||Feb 17, 2005||Alferness Clifton A.||Mitral valve therapy device, system and method|
|US20050060030 *||Jul 19, 2004||Mar 17, 2005||Lashinski Randall T.||Remotely activated mitral annuloplasty system and methods|
|US20050065598 *||Aug 4, 2004||Mar 24, 2005||Mathis Mark L.||Device, assembly and method for mitral valve repair|
|US20050096666 *||Sep 20, 2004||May 5, 2005||Gordon Lucas S.||Percutaneous mitral valve annuloplasty delivery system|
|US20050096740 *||Nov 1, 2004||May 5, 2005||Edwards Lifesciences Ag||Transluminal mitral annuloplasty|
|US20050107810 *||Feb 10, 2004||May 19, 2005||Guided Delivery Systems, Inc.||Devices and methods for heart valve repair|
|US20060020335 *||Sep 23, 2005||Jan 26, 2006||Leonard Kowalsky||System and method to effect the mitral valve annulus of a heart|
|US20060030882 *||Oct 7, 2005||Feb 9, 2006||Adams John M||Transvenous staples, assembly and method for mitral valve repair|
|US20060041305 *||Aug 17, 2005||Feb 23, 2006||Karl-Lutz Lauterjung||Prosthetic repair of body passages|
|US20070066879 *||Oct 17, 2006||Mar 22, 2007||Mathis Mark L||Body lumen shaping device with cardiac leads|
|US20080097594 *||Dec 21, 2007||Apr 24, 2008||Cardiac Dimensions, Inc.||Device and Method for Modifying the Shape of a Body Organ|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US7625399||Oct 10, 2006||Dec 1, 2009||Cook Incorporated||Intralumenally-implantable frames|
|US7658759||Jul 17, 2006||Feb 9, 2010||Cook Incorporated||Intralumenally implantable frames|
|US7666224||Jul 7, 2005||Feb 23, 2010||Edwards Lifesciences Llc||Devices and methods for heart valve treatment|
|US7670368||Mar 2, 2010||Boston Scientific Scimed, Inc.||Venous valve apparatus, system, and method|
|US7674287||Aug 24, 2006||Mar 9, 2010||Cardiac Dimensions, Inc.||Device and method for modifying the shape of a body organ|
|US7678145||Jul 1, 2005||Mar 16, 2010||Edwards Lifesciences Llc||Devices and methods for heart valve treatment|
|US7682385||Jul 3, 2006||Mar 23, 2010||Boston Scientific Corporation||Artificial valve|
|US7717952||Oct 25, 2006||May 18, 2010||Cook Incorporated||Artificial prostheses with preferred geometries|
|US7722666||Apr 15, 2005||May 25, 2010||Boston Scientific Scimed, Inc.||Valve apparatus, system and method|
|US7758639||Jan 18, 2007||Jul 20, 2010||Cardiac Dimensions, Inc.||Mitral valve device using conditioned shape memory alloy|
|US7766812||Apr 14, 2006||Aug 3, 2010||Edwards Lifesciences Llc||Methods and devices for improving mitral valve function|
|US7776053||Dec 12, 2006||Aug 17, 2010||Boston Scientific Scimed, Inc.||Implantable valve system|
|US7780627||Jul 16, 2007||Aug 24, 2010||Boston Scientific Scimed, Inc.||Valve treatment catheter and methods|
|US7780722||Feb 7, 2005||Aug 24, 2010||Boston Scientific Scimed, Inc.||Venous valve apparatus, system, and method|
|US7794496||Dec 19, 2003||Sep 14, 2010||Cardiac Dimensions, Inc.||Tissue shaping device with integral connector and crimp|
|US7799038||Jan 20, 2006||Sep 21, 2010||Boston Scientific Scimed, Inc.||Translumenal apparatus, system, and method|
|US7814635||May 12, 2006||Oct 19, 2010||Cardiac Dimensions, Inc.||Method of making a tissue shaping device|
|US7828841||Dec 21, 2007||Nov 9, 2010||Cardiac Dimensions, Inc.||Device and method for modifying the shape of a body organ|
|US7828842||Nov 9, 2010||Cardiac Dimensions, Inc.||Tissue shaping device|
|US7828843||Aug 24, 2004||Nov 9, 2010||Cardiac Dimensions, Inc.||Mitral valve therapy device, system and method|
|US7837728||Dec 19, 2003||Nov 23, 2010||Cardiac Dimensions, Inc.||Reduced length tissue shaping device|
|US7837729||Sep 20, 2004||Nov 23, 2010||Cardiac Dimensions, Inc.||Percutaneous mitral valve annuloplasty delivery system|
|US7854755||Feb 1, 2005||Dec 21, 2010||Boston Scientific Scimed, Inc.||Vascular catheter, system, and method|
|US7854761||Dec 19, 2003||Dec 21, 2010||Boston Scientific Scimed, Inc.||Methods for venous valve replacement with a catheter|
|US7857846||May 2, 2003||Dec 28, 2010||Cardiac Dimensions, Inc.||Device and method for modifying the shape of a body organ|
|US7878966||Feb 4, 2005||Feb 1, 2011||Boston Scientific Scimed, Inc.||Ventricular assist and support device|
|US7883539||Apr 23, 2002||Feb 8, 2011||Edwards Lifesciences Llc||Heart wall tension reduction apparatus and method|
|US7887582||May 5, 2004||Feb 15, 2011||Cardiac Dimensions, Inc.||Device and method for modifying the shape of a body organ|
|US7892276||Dec 21, 2007||Feb 22, 2011||Boston Scientific Scimed, Inc.||Valve with delayed leaflet deployment|
|US7951189||Jul 27, 2009||May 31, 2011||Boston Scientific Scimed, Inc.||Venous valve, system, and method with sinus pocket|
|US8250960||Aug 29, 2011||Aug 28, 2012||Cardiac Dimensions, Inc.||Catheter cutting tool|
|US8974525||Oct 19, 2010||Mar 10, 2015||Cardiac Dimensions Pty. Ltd.||Tissue shaping device|
|US20040220657 *||Dec 19, 2003||Nov 4, 2004||Cardiac Dimensions, Inc., A Washington Corporation||Tissue shaping device with conformable anchors|
|US20050187619 *||Nov 19, 2004||Aug 25, 2005||Mathis Mark L.||Body lumen device anchor, device and assembly|
|U.S. Classification||623/2.11, 623/2.37|
|International Classification||A61B17/00, A61F2/24, A61N1/05|
|Cooperative Classification||A61N1/057, A61F2/2451, A61B2017/00243, A61N2001/0585|
|European Classification||A61N1/05N4, A61F2/24R4|
|May 18, 2005||AS||Assignment|
Owner name: CARDIAC DIMENSIONS, INC., WASHINGTON
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MATHIS, MARK L.;NIEMINEN, GREGORY D.;REUTER, DAVID G.;REEL/FRAME:016587/0570
Effective date: 20020130