|Publication number||US20060002799 A1|
|Application number||US 11/157,638|
|Publication date||Jan 5, 2006|
|Filing date||Jun 21, 2005|
|Priority date||Jun 30, 2004|
|Also published as||CN1715650A, CN100554685C, DE602005015789D1, EP1612423A1, EP1612423B1|
|Publication number||11157638, 157638, US 2006/0002799 A1, US 2006/002799 A1, US 20060002799 A1, US 20060002799A1, US 2006002799 A1, US 2006002799A1, US-A1-20060002799, US-A1-2006002799, US2006/0002799A1, US2006/002799A1, US20060002799 A1, US20060002799A1, US2006002799 A1, US2006002799A1|
|Inventors||Christian Schann, Stephane Olivier, Raphael Grinon, Bertrand Engel|
|Original Assignee||Millipore Corporation|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (15), Referenced by (6), Classifications (7), Legal Events (1)|
|External Links: USPTO, USPTO Assignment, Espacenet|
The invention relates to the general field of peristaltic pumps.
It relates more particularly to a peristaltic pump comprising a bearing member and a counter-member between which a tube on which said pump must act is gripped.
A peristaltic pump, as used in the medical field in particular, is a pump whose rotor is provided incorporating rollers that progressively compress the cross section of an elastic tube to move a liquid along the tube.
This kind of pump is therefore used to circulate a fluid inside a tube by operating only on the tube, without coming into contact with the liquid. This type of pump is therefore suitable for any application requiring the fluid to remain in a confined atmosphere, for example to avoid contamination of the fluid when working in a sterile environment. A peristaltic pump is generally adapted to operate in an environment where the concept of sterility is of primordial importance. The pump must therefore not only fulfill its function of circulating a fluid and preventing its contamination by the environment, but also avoid contamination of the environment by the pump itself. The various components of the pump must therefore be easy to clean, where appropriate by being demountable, at the same time as ensuring a perfect seal.
A peristaltic pump typically comprises a rotor comprising rollers at its periphery and a mobile jaw adapted to assume an open position, in which it is moved away from the rotor so that an elastically deformable tube on which the pump has to act may be placed between the jaw and the rotor, and a closed position, in which the mobile jaw is moved toward the rotor so that the tube is gripped between a curved bearing surface on the mobile jaw and at least one roller of the rotor.
Peristaltic pumps of the above kind are known in the art in which the mobile jaw comprises an excrescence formed by a bearing member and in which the pump body is provided with a counter-member disposed so that, when the jaw is in its open position, the member is moved away from the counter-member and, when the mobile jaw is in its closed position, the bearing member is moved toward the counter-member so that, when a tube is fitted into the pump, the tube is gripped between the bearing member and the counter-member. This gripping action generally has the function of holding the tube in place while the pump is operating.
The peristaltic pumps available at present generally allow visual inspection of the correct position of the tube between the rotor and the mobile jaw when the latter is in the closed position. Similarly, correct circulation of the fluid inside the tube may be monitored visually or automatically on the upstream and/or downstream side of the pump.
The object of the invention is to improve the above type of pump.
To this end, the invention provides a peristaltic pump comprising a rotor incorporating rollers and a mobile jaw that is provided with a bearing member and assumes:
The above kind of pump therefore has access at all times to information relating to the force that is exerted by the tube when it is fitted into the pump. This force being representative of the elastic behavior of the combination of the tube and the liquid that it conveys, various measurement or monitoring parameters can be monitored in this way.
Firstly, the sensor may provide information relating to the presence or the absence of a force exerted between the bearing member and the counter-member.
The processing unit therefore has access to information indicating that the tube is in place or, to the contrary, that a misoperation has occurred since the tube is not in position between the bearing member and the counter-member.
To obtain the best results, the force sensor may be integrated into the counter-member.
In this case, the counter-member may comprise a first assembly that comprises:
The counter-member may also comprise a second assembly identical to and independent of the first assembly in order to be able to carry out independent measurements relating to the two passages of a dual passage tube.
According to one preferred feature of the invention, the processing unit comprises a memory in which a signal-pressure coefficient is stored, the processing unit being adapted to process the value of the signal supplied by the force sensor according to said signal-pressure coefficient to obtain the pressure of the fluid circulating in the tube.
Thus the sensor may provide information relating to the pressure of the fluid circulating in the tube. The processing unit then has access to a conversion coefficient for the force measured by the fluid pressure sensor. The above kind of pump may therefore provide a display of the instantaneous pressure of the fluid circulating in the tube.
For enhanced measurements, the following features may be implemented independently of each other:
Also, the pump may have additional functions by virtue of the following features, which may be implemented independently of each other:
Other features and advantages of the invention will become apparent in the light of the following description of a preferred embodiment of the invention, which is given by way of nonlimiting example and with reference to the appended drawings, in which:
FIGS. 14 to 16 are plan views of the pump head shown in
FIGS. 17 to 19 are views from below, from the side, and from in front, respectively, of the counter-member shown in
FIGS. 20 to 22 show the counter-member, in a similar manner to FIGS. 17 to 19, but after receiving a treatment intended to seal it;
In the present example, the pump 1 comprises accessories such as a bottle rack 2 and a flow drawer 3. This configuration is used to pump the liquid contained in a bottle 4 toward two containers 5 through a tube connected at one end to the bottle 4 and at the other end to the containers 5.
In this example the tube 6 comprises two separate passages sealed with respect to each other and connected to each other by a longitudinal web 7 that is easy to cut.
The peristaltic pump 1 comprises a pump body 8 on which are disposed a display 9 and control keys 10.
The pump 1 also comprises a pump head 11 (shown in
A mobile jaw 15 is fixed to the inside wall of the envelope 13 by three screws 16. The general shape of the mobile jaw 15 is that of a crescent moon, the inside wall of its curved portion comprising a curved bearing surface 17 of circular arc shape. On respective opposite sides of this bearing surface 17 the mobile jaw 15 comprises a tooth 18 and a bearing member 19, both adapted to cooperate with the tube 6, like the bearing surface 17.
The mobile jaw 15 further comprises a hole 20 through the wall of the envelope 13 (see
A round hole 21 communicating with an oblong hole 22 is also formed in the thickness of the mobile jaw 15. In
The pump head 11 also receives a rotatably mounted rotor 26 incorporating rollers and a plate 27 from which projects an eccentric finger 28.
The flange 29 that is the upper flange in
The disposition of the cylindrical rollers 30, the centering rollers 31 and the flat 32 may be seen in
The portion of the groove 14 visible in
Note that when the tube 6 is pressed into this portion of the groove 14 (see
Although the lower passage of the tube 6 is retained in its housing by the bosses 37, a clearance remains between the tube 6 and the locating member, which allows the sliding previously referred to (see
The tube 6 is also removed by elastically deforming the lower passage of the tube 6, which likewise overcomes the hard point.
The plate 27 is fastened to a drive shaft 38 that is mounted on bearings and rotates relative to the pump head 11. The shaft 38 is fastened to a gear 39 meshing with a worm gear 40 that is driven in rotation by a motor (not shown).
FIGS. 14 to 16 are plan views of the assembly shown in
The successive positions represented in FIGS. 14 to 16 are not visible from the outside in normal use of the pump 1, this region being covered by the cap 12 that is normally fitted over the jaw 15.
FIGS. 17 to 19 are various views of the counter-member 24 that is mounted on the pump head 11.
The counter-member 24 further comprises an upper contact member 49 and a lower contact member 50 rigidly fixed to the upper test body 41 and the lower test body 42, respectively.
Given the position of the pins 44 and the screws 45 securing the test bodies 41, 42 to the flanges 43, the test body 41, 42 may be deformed when a force is applied to the contact members 49, 50.
FIGS. 20 to 22 are views of the counter-member 24 analogous to FIGS. 17 to 19; here the counter-member 24 comprises a resilient seal 51 that fills up the interstices between the flanges 43 and the test bodies 41, 42 fitted with their contact members 49, 50. The resilience of this seal provides the sealing effect and at the same time allows relative movement of the test bodies 41, 42 and the flanges 43. The material of the resilient seal 51 must have a negligible stiffness compared to that of the test bodies 41, 42 and the flanges 43. The test bodies 41, 42 may be made from a high strength martensitic stainless steel, for example, conforming to the French standard AFNOR Z40 CNV 14, and tempered/annealed to an HRC hardness of 45, whereas the flanges 43 and the contact members 49, 50 may be made of ordinary stainless steel; in this case the resilient seal 51 may be made of silicone. Generally speaking, all interstices and orifices between the test bodies 41, 42, the contact members 49, 50 and the flanges 43 may be filled in by this kind of seal, to obtain a perfect seal.
Each of the test bodies comprises a base 52 from which extends a curved portion 53 which has at its end a dovetail mortise 54 in which a dovetail tenon 55 on the corresponding contact member 49, 50 engages. Each base 52 comprises transverse holes 56 for inserting the pin 44 and the screw 45 and an orifice 56′ for fixing a rear wall (not shown).
Each of the test bodies 41, 42 has a strain gauge 57 fixed to the inside wall of the curved portion 53. The strain gauges 57 are adapted to measure deformation of the curved portion 53 to which they are fixed. Such deformation may occur when the counter-member 24 is fixed to the pump head 11 by screws inserted into the tapped holes 47 and a force is exerted on one of the contact members 49, 50.
Note that deformation of the curved portion 53 of one of the test bodies is independent of deformation of the curved portion 53 of the other test body, since the test bodies 41, 42 are connected only at their base 52, via the flanges 43.
The strain gauges may be connected into a Wheatstone bridge, for example, in a manner that is well known in the field of mechanical engineering.
Cables (not shown) passing through the orifice 46 connect each of the gauges 57 to the control circuitry of the pump 1.
The processing unit 58 comprises a module 59 for compensating creep of the tube 6, a module 60 for controlling closing of the mobile jaw 15, and a module 61 for filtering pulsation of the pump 1.
The functions of the processing unit, whose operation is explained hereinafter, may be provided by appropriate electronic circuitry or by an appropriately programmed data processing device.
The peristaltic pump 1 that has just been described operates in the manner indicated hereinafter.
When the pump 1 is started, the mobile jaw 15 is in the position shown in
First of all, a tube 6 is fitted to the pump 1. To this end, as shown in
Once this operation has been effected, intervention of the user insofar as the positioning of the tube 6 in the pump 1 is concerned is no longer necessary.
Using the control keys 10, the user indicates that he wishes to start the pump 1, which drives rotation of the plate 27 via its drive system until the mobile jaw 15 reaches the position shown in
When this position is reached, the motor stalls and draws a higher current. When this consumption peak is detected, the motor is stopped.
As the jaw 15 closes, the tube 6 is wrapped around the rotor 26 and at the same time slides as required in the locating members of the cap 12.
The tube 6 is finally held on either side of the rotor 26 by the cooperation of the tooth 18 and the immobilizing pin 25, on the one hand, and by the cooperation of the bearing member 19 and the counter-member 24, on the other hand, which lightly grip both passages of the tube 6.
The mobile jaw 15 is held in this closure position because of the irreversible nature of the system comprising the wheel 39 and the worm 40. The pitch and the helix angle of these components are chosen, in a manner that is well known in the art of mechanical engineering, so that rotation of the worm 40 drives the wheel 39 but rotation of the wheel 39 is not able to drive rotation of the worm 40.
When the tube 6 has been inserted in this way, the rotor 26 may be rotated to start circulating the fluid contained in the tube 6 thanks to the movement of the rollers 30.
When the pump 1 is operating, the safety of the user is ensured by the fact that the mobile jaw 15 is in the
On the other hand, when the pump 1 is powered down, the eccentric finger 28 resumes the position shown in
The pump 1 further comprises means for obtaining, via the counter-member 24, information relating to the tube 6 and to the circulating fluid and to operate accordingly on the pump 1.
The counter-member 24 is connected to a processing unit (
Once the tube has been fitted, and with the pump head in the
If the presence of the tube 6 is not detected, the pump 1 does not start and displays an error message.
Once the tube has been positioned correctly and the pump is operating, the processing unit 58 supplies to the output peripherals the instantaneous pressure of the fluid in each of the passages of the tube 6, independently of each other.
The signal-pressure coefficient is determined empirically, during a preliminary calibration phase, by installing a tube with known characteristics in the pump 1 and applying to it a known pressure. The voltage delivered by the strain gauges 57 is then read off; the pressure corresponding to this value being known, the coefficient may be determined. It may be determined for each new tube used. An average value may be obtained by subjecting a plurality of tubes to this test and determining from the test results a mean coefficient valid for all the tubes.
The processor unit 58 may use the measured pressure of the fluid in the tube 6 for the following supplementary applications.
The processing unit 58 includes a module 59 for compensating creep of the tube 6, which improves the reliability of the measurements. To this end, at regular intervals, for example every 20 milliseconds, the module 59 measures the voltage supplied by the strain gauges 57 and effects a dynamic calibration, from one measurement to the next, taking the lowest voltage as the reference value for calculating the zero pressure.
The processing unit 58 also includes a module 60 for controlling closure of the mobile jaw 15 that is adapted to regulate the speed of the mobile jaw 15 when it moves from its open position to its closed position, leading to compression of the tube 6 between the bearing member 19 and the counter-member 24. Tightening the mobile jaw 15 too quickly disturbs the pressure measurement, because of the elasticity of the tube 6.
The module 60 may therefore slow down the closing of the mobile jaw (i.e. slow down the motor of the eccentric finger 28) if the pressure measurement is disturbed.
The module 60 may further be programmed to start the closure of the mobile jaw 15 at a high speed and then to clamp the tube 6 at a lower speed, once the tube 6 reaches the vicinity of the counter-member 24.
The processing unit 58 further comprises a module 61 for filtering pulsation of the pump 1. The movement of the rotor 26 acting on the tube 6 during the operation of the pump 1 causes cyclic disturbances to the pressure measurement, these disturbances depending on the rotation frequency of the rotor 26.
The module 61 applies electronic filtering, for example by means of a low-pass RC filter setting a cut-off frequency.
In the present example, the rotation speed of the rotor 26 is 240 rpm and the rotor comprises three rollers, which corresponds to an angular frequency of 12 Hz. A cut-off frequency of 1.5 Hz may then be defined by an appropriate RC filter; this value gives good results.
The processing unit 58 may also slave the rotation speed of the rotor 26 to the measured pressure of the fluid in the tube 6. For example, if the processor unit 58 has information relating to the permitted maximum pressure in the tube 6, the rotation speed of the pump may be increased to the maximum and then reduced on demand, if the pressure in the tube 6 approaches its permitted maximum value.
Similarly, by indicating abnormal variations in fluid pressure, the processing unit 58 may detect incorrect flow of the fluid in the tube 6, linked to clogging of the tubes, for example.
Variants of the device may be envisaged that do not depart from the scope of the invention. In particular, the tube 6 may comprise a single passage or more than two passages, the counter-member comprising as many test bodies as there are passages.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3918854 *||Jun 19, 1974||Nov 11, 1975||Alphamedics Mfg Corp||Peristaltic pump|
|US4784577 *||Mar 13, 1987||Nov 15, 1988||Critikon, Inc.||Pump pressure sensor|
|US4976590 *||Jun 8, 1988||Dec 11, 1990||Baldwin Brian E||Fluid conduit-responsively adjustable pump arrangement and pump/conduit arrangement and method, and fluid conduits therefor|
|US5103211 *||Nov 6, 1990||Apr 7, 1992||Ivac Corporation||Apparatus for detecting fluid line occlusion|
|US5215450 *||Mar 14, 1991||Jun 1, 1993||Yehuda Tamari||Innovative pumping system for peristaltic pumps|
|US5217355 *||Aug 5, 1991||Jun 8, 1993||Imed Corporation||Two-cycle peristaltic pump with occlusion detector|
|US5388972 *||Mar 9, 1994||Feb 14, 1995||Medical Laboratory Automation, Inc.||Peristaltic pump with removable tubing of precise length|
|US5661245 *||Jul 14, 1995||Aug 26, 1997||Sensym, Incorporated||Force sensor assembly with integrated rigid, movable interface for transferring force to a responsive medium|
|US5709539 *||May 21, 1996||Jan 20, 1998||Varian Associates, Inc.||Pressing plate for linearized pulses from a peristaltic pump|
|US6017318 *||Dec 15, 1997||Jan 25, 2000||Gensia Automedics, Inc.||Feedback controlled drug delivery system|
|US6123524 *||Jan 28, 1998||Sep 26, 2000||Baxter International Inc.||Volumetric infusion pump with automatic tube loader|
|US6164921 *||Nov 9, 1998||Dec 26, 2000||Moubayed; Ahmad Maher||Curvilinear peristaltic pump having insertable tubing assembly|
|US6347553 *||Feb 28, 2000||Feb 19, 2002||Alaris Medical Systems, Inc.||Force sensor assembly for an infusion pump|
|US6731216 *||May 20, 2002||May 4, 2004||B. Braun Medical, Inc.||Proper tubing installation testing method and apparatus for a peristaltic pump|
|US20050196307 *||Mar 3, 2005||Sep 8, 2005||Cole-Parmer Instrument Company||Peristaltic pump|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US7467932 *||Jun 14, 2005||Dec 23, 2008||Millipore Corporation||Peristaltic pump comprising members for locating a tube|
|US7762788 *||Jul 31, 2007||Jul 27, 2010||Seiko Epson Corporation||Fluid conveyance system and fluid conveyance device|
|US7934912||Sep 27, 2007||May 3, 2011||Curlin Medical Inc||Peristaltic pump assembly with cassette and mounting pin arrangement|
|US8251954 *||Apr 24, 2006||Aug 28, 2012||Seiko Epson Corporation||Fluid transportation system and method of setting fluid ejection amount|
|US8858185||Jun 21, 2011||Oct 14, 2014||Hospira, Inc.||Fluid flow rate compensation system using an integrated conductivity sensor to monitor tubing changes|
|US20060002805 *||Jun 14, 2005||Jan 5, 2006||Millipore Corporation||Peristaltic pump comprising members for locating a tube|
|International Classification||F04B49/06, F04B49/00|
|Cooperative Classification||F04B43/12, F04B49/065|
|European Classification||F04B49/06C, F04B43/12|
|Jun 21, 2005||AS||Assignment|
Owner name: MILLIPORE CORPORATION, MASSACHUSETTS
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:SCHANN, CHRISTIAN;OLIVIER, STEPHANE;GRINON, RAPHAEL;AND OTHERS;REEL/FRAME:016695/0210
Effective date: 20050518