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Publication numberUS20060025716 A1
Publication typeApplication
Application numberUS 11/207,334
Publication dateFeb 2, 2006
Filing dateAug 18, 2005
Priority dateOct 6, 2000
Also published asUS6964647, US20090024076, WO2002028350A2, WO2002028350A3, WO2002028350A8
Publication number11207334, 207334, US 2006/0025716 A1, US 2006/025716 A1, US 20060025716 A1, US 20060025716A1, US 2006025716 A1, US 2006025716A1, US-A1-20060025716, US-A1-2006025716, US2006/0025716A1, US2006/025716A1, US20060025716 A1, US20060025716A1, US2006025716 A1, US2006025716A1
InventorsEilaz Babaev
Original AssigneeEilaz Babaev
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Nozzle for ultrasound wound treatment
US 20060025716 A1
Abstract
A nozzle for ultrasound wound treatment comprising a main body with proximal and distal ends, a reservoir and valve. The proximal end of the nozzle being removably attached to an ultrasound transducer. The distal end of the nozzle being marginally close and coaxial to the free distal end of the ultrasound transducer. The body of the nozzle connected with liquid reservoir, which holds the wound treatment solution and delivers same to the free end of ultrasound tip directly or through a tube. The nozzle is provided with valve for controlling flow rate of wound treatment solution. The nozzle can mix different liquids or a liquid with a gas and deliver same to the wound surface. The nozzle can also be provided with trigger system for one hand use. The present invention is a device, using ultrasonic waves to create, direct and deliver liquid treatment spray to a wound surface.
Images(11)
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Next page
Claims(21)
1-43. (canceled)
44. A method for treating a wound comprising:
providing a transducer having a distal radiation surface in proximity to the surface of the wound for emitting ultrasonic energy;
providing a nozzle having a main body supported by the transducer, the main body having a proximal end that removably attaches to a housing of the transducer, the main body having a distal end positioned at a distance from the distal radiation surface of the transducer, the main body defining an opening for delivering a fluid to the distal radiation surface of the transducer for producing a spray; and
delivering the emitted ultrasonic energy to the wound through the spray.
45. The method according to claim 44, wherein the nozzle comprises a valve for controlling a flow rate of the fluid through said opening.
46. The method according to claim 44, further comprising the step of storing the fluid within a reservoir in fluid communication with said opening.
47. The method according to claim 44, wherein the ultrasonic energy provides a bactericidal and a therapeutic effect for decreasing the healing time for the wound.
48. The method according to claim 47, wherein the therapeutic effect is selected from the group consisting of delivering at least one medicament to the wound, cleansing a surface of the wound, and stimulating healthy tissue cells.
49. The method according to claim 44, wherein the fluid includes one or more components selected from the group consisting of gas, drugs, liquid, and saline.
50. The method according to claim 44, wherein the distal radiation surface is threaded.
51. The method according to claim 44, further comprising the step of introducing a second fluid to the distal radiation surface, and wherein the step of delivering the emitted ultrasonic energy to the wound includes the step of delivering the second fluid to the wound.
52. The method according to claim 44, wherein the distal radiation surface has a shape selected from the group consisting of cylindrical, multiangular, rectangular, elliptical, ovular, and conical.
53. A wound treatment device for treating a wound, said device comprising:
a transducer having a distal radiation surface for emitting ultrasonic energy; and
a nozzle having a main body supported by the transducer, the main body having a proximal end that removably attaches to a housing of the transducer, the main body having a distal end positioned at a distance from the distal radiation surface of the transducer, the main body defining an opening for delivering a fluid to the distal radiation surface of the transducer for producing a spray, wherein the emitted ultrasonic energy is delivered to the wound through the spray.
54. The device according to claim 53, wherein the nozzle comprises a valve for controlling a flow rate of the fluid through said opening.
55. The device according to claim 53, further comprising a reservoir storing said fluid and in fluid communication with said opening.
56. The device according to claim 53, wherein the ultrasonic energy provides a bactericidal and a therapeutic effect for decreasing the healing time for the wound.
57. The device according to claim 56, wherein the therapeutic effect is selected from the group consisting of delivering at least one medicament to the wound, cleansing a surface of the wound, and stimulating healthy tissue cells.
58. The device according to claim 53, wherein the fluid includes one or more components selected from the group consisting of gas, drugs, liquid, and saline.
59. The device according to claim 53, wherein the distal radiation surface is threaded.
60. The device according to claim 53, wherein the distal radiation surface has a shape selected from the group consisting of cylindrical, multiangular, rectangular, elliptical, ovular, and conical.
61. The device according to claim 55, further comprising a second reservoir in fluid communication with a second opening defined by the main body of the nozzle for introducing a second fluid to the distal radiation surface of the transducer.
62. The device according to claim 55, further comprising a propagation path in fluid communication with the reservoir and said opening.
63. The device according to claim 62, further comprising at least one valve positioned along the propagation path for controlling a flow rate of the fluid.
Description
    FIELD OF THE INVENTION
  • [0001]
    The present invention relates to a device for using ultrasonic waves in wound treatment. More particularly, the present invention relates to a device for spraying a wound surface using ultrasonic waves for delivering drugs, killing bacteria, cleansing a surface, and stimulating healthy tissue cells.
  • BACKGROUND OF THE INVENTION
  • [0002]
    Ultrasonic waves have been widely used in medical applications, including both diagnostics and therapy as well as in many industrial applications. One diagnostic use of ultrasound waves includes using ultrasonic waves to detect underlying structures in an object or a human tissue. In this procedure, an ultrasonic transducer is placed in contact with the object or tissue via a coupling medium and high frequency (1-10 MHz) ultrasonic waves are directed into the tissue. Upon contact with the various underlying structures, the waves are reflected back to a receiver adjacent to the transducer. By comparison of the signals of the ultrasonic wave as sent with the reflected ultrasonic wave as received, an image of the underlying structure can be produced. This technique is particularly useful for identifying boundaries between components of tissue and can be used to detect irregular masses, tumors and the like.
  • [0003]
    Two therapeutic medical uses of ultrasound waves include aerosol mist production and contact physiotherapy. Aerosol mist production makes use of a nebulizer or inhaler to produce an aerosol mist for creating a humid environment and delivering drugs to the lungs. Ultrasonic nebulizers operate by the passage of ultrasound waves of sufficient intensity through a liquid, the waves being directed at an air-liquid interface of the liquid from a point underneath or within the liquid. Liquid particles are ejected from the surface of the liquid into the surrounding air following the disintegration of capillary waves produced by the ultrasound. This technique can produce a very fine dense fog or mist. Aerosol mists produced by ultrasound are preferred over aerosol mists produced by other methods because a smaller particle size of the aerosol can be obtained with the ultrasonic waves. One of the major shortcomings of inhalers and nebulizers is that the aerosol mist cannot be directed to a target area without an air stream which decreases the efficiency of ultrasound.
  • [0004]
    Ultrasonic sprayers such as those sold by Sonic and Materials Inc., Misonix Inc., Sono-Tek Inc., and Zervex International, Inc. (see, for example, U.S. Pat. Nos. 4,659,014, 5,104,042, 4,930,700, 4,153,201, 4,655,393, 5,516,043, 5,835,678, 5,879,364, and 5,843,139) operate by passing liquid through a central orifice of an ultrasound instrument-tip. These ultrasonic devices do not have and do not need any removable nozzles to create a liquid spray.
  • [0005]
    Ultrasonic inhalers and drug delivery systems from Medisonic USA, Inc., 3M, Siemens Gmb, The Procter & Gamble Company, Sheffield Pharmaceuticals, and Aradigm, Inc. (see, for example, U.S. Pat. Nos. 4,294,407, 5,347,998, 5,520,166, 5,960,792, 6,095,141, 6,102,298, 6,098,620, 6,026,808, and 6,106,547) operate by atomizing liquid using piezoceramic film. Although some inhalers and delivery systems use nozzles, the nozzles are just for directing the atomized liquid to the mouth by touching the lips. These nozzles do not create any spray, and the inhaler and drug delivery systems can work without them.
  • OBJECTS OF THE INVENTION
  • [0006]
    It is an object of this invention to provide an improved device for treating wounds.
  • [0007]
    It is also an object of this invention to provide an improved device for treating wounds using ultrasonic waves.
  • [0008]
    It is a further object of the invention to provide a device for creating, directing and delivering liquid aerosol spray to a wound surface.
  • [0009]
    It is yet a further object of the invention to provide a device for creating ultrasonic waves and delivering drugs, killing bacteria, cleansing a surface, and/or stimulating healthy tissue.
  • [0010]
    These and other objects of the invention will become more apparent from the more detailed discussion below.
  • SUMMARY OF THE INVENTION
  • [0011]
    The present invention relates to a device using ultrasonic waves to create, direct and deliver liquid aerosol spray to a wound surface. More particularly, the present invention relates to an emission device comprising a nozzle which is a preferably cylindrical, but optionally can be multiangular, from the inside and is cylindrical, rectangular or multiangular from the outside distal end; a liquid reservoir; and a different shaped proximal end to be removably attached to ultrasound transducer.
  • [0012]
    The liquid reservoir is provided with a valve, which works as a dispenser and allows liquid to reach the ultrasound tip as drops or via continuous flow through an orifice and a gap.
  • [0013]
    The proximal end of the nozzle can be connected to the transducer housing in a variety of different ways, such as by threads, bolts or screwed on, snap/friction fit, or by other means.
  • [0014]
    The liquid reservoir portion of the nozzle can be attached to the top, side, or bottom of the nozzle body or located outside the nozzle body. Liquid from the reservoir may be delivered under gravity, or by motorized pump. The liquid reservoir can be elastic or rigid, with or without a cover, and can be made from a variety of different materials, such as, for example, metal, plastic, rubber, ceramic, or other suitable material, and is provided with metered dose device or a liquid dispenser.
  • [0015]
    The liquid reservoir can provide the free end of an ultrasound transducer tip with liquid/solution directly from inside the distal end of the nozzle, or through an orifice or a tube from the front end of the nozzle.
  • [0016]
    The nozzle can be provided with two, three or more reservoirs or tubes, for mixing different liquids, drugs or liquid(s) with gas. For example, saline can be mixed with oxygen and used to treat a wound. Gas and liquid can be delivered separately from the top, side and bottom of the distal end of the ultrasound transducer to be mixed and sprayed on the wound surface.
  • [0017]
    The valve part of the nozzle can be located between the reservoir and nozzle body, inside of the reservoir, or inside of the nozzle. The nozzle can optionally be provided with a trigger connecting and operating the valve. This design allows a user to operate the device with one hand. The trigger can be located on the top, side or bottom of the nozzle.
  • [0018]
    The nozzle can work without a valve, if, for example, the reservoir is made from an elastic rubber material. In this case liquid from the reservoir is delivered by squeezing the elastic reservoir.
  • [0019]
    The main body and distal end of the nozzle may be cylindrical, oval, elliptic, conical, rectangular or multiangular from the inside.
  • [0020]
    From the outside, the main body and distal end of the nozzle can be any shape such as, for example, a cylinder, cut cylinder, cone, cut cone, concave, double cut, rectangular, multiangular or a combination of these shapes.
  • [0021]
    The proximal end of the nozzle can be any shape, but must be removably attachable to the ultrasound transducer, for example, via threads, friction fit, screws, slots, spline, or other means.
  • [0022]
    The shape of the distal end of the nozzle as viewed from the horizontal side can be cylindrical, a cut cylinder, conical, a double cut cylinder or cone, spherical, elliptic/oval or curved, multiangular, waved or a combination of these shapes.
  • [0023]
    Finally the ultrasound wound treatment nozzle can be comprised of many different parts, such as a body/housing, reservoir, valve, and dispenser, or formed in one solid part.
  • [0024]
    While the invention has been described in general terms, the construction and obvious advantages of the device will be more clearly understood with reference to the following description of the various specific embodiments when read in conjunction with the accompanying drawings.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0025]
    FIG. 1 is a cross-sectional view of a side elevation of a preferred embodiment of the nozzle and fluid reservoir for ultrasound wound treatment according to the invention.
  • [0026]
    FIG. 2 a) is a cross-sectional view of the nozzle of FIG. 1 with the liquid reservoir located in the preferred top position.
  • [0027]
    FIG. 2 b) is a cross-sectional end view of the nozzle of FIG. 1 with the liquid reservoir located in the side position.
  • [0028]
    FIG. 2 c) is another cross-sectional view of the nozzle of FIG. 1 with the liquid reservoir located in the bottom position.
  • [0029]
    FIG. 2 d) is another cross-sectional view of the nozzle of FIG. 1 with the liquid reservoir located to one side of the preferred top position.
  • [0030]
    FIG. 3 a) is a cross-sectional elevation view of the nozzle of FIG. 1 with the reservoir providing the tip of the nozzle with liquid directly from inside.
  • [0031]
    FIG. 3 b) is another cross-sectional elevation view of the nozzle of FIG. 1 with the reservoir providing the tip of the nozzle with liquid through an orifice or tube from the front end of the nozzle.
  • [0032]
    FIG. 4 a) is a cross-sectional view of the nozzle of FIG. 1 showing the nozzle with multiple liquid entry points.
  • [0033]
    FIG. 4 b) is top plan view of the nozzle according to the invention showing three liquid/fluid reservoirs located side by side.
  • [0034]
    FIG. 4 c) is a cross-sectional end elevation view of the nozzle depicted in FIGS. 4 a and 4 b showing the three reservoirs located side by side with three separate entry points located at different points around the nozzle.
  • [0035]
    FIG. 5 a) is a cross-sectional elevation view of the nozzle of FIG. 1 showing the control valve located within the housing of the liquid reservoirs.
  • [0036]
    FIG. 5 b) is a cross-sectional elevation view of the nozzle of FIG. 1 showing the control valve located outside the body of the liquid reservoir, but within the body housing of the nozzle.
  • [0037]
    FIG. 5 c) is a cross-sectional elevation view of the nozzle of FIG. 1 showing the control valve located at various points along the transfer tube.
  • [0038]
    FIG. 6 is a cross-sectional elevation view of the nozzle of FIG. 1 showing the liquid reservoir in the bottom position without a control valve, where the fluid is delivered via squeezing on a flexible liquid reservoir.
  • [0039]
    FIG. 7 is a cross-sectional side elevation view of the nozzle of FIG. 1 with the fluid reservoir in the top position employing a trigger to open/close the control valve.
  • [0040]
    FIG. 8 a) is a cross-sectional elevation of the nozzle of FIG. 1 showing the distal end of the nozzle with a cylindrical shape.
  • [0041]
    FIG. 8 b) is a cross-sectional elevation of the nozzle of FIG. 1 showing the distal end of the nozzle with an oval shape.
  • [0042]
    FIG. 8 c) is a cross-sectional elevation of the nozzle of FIG. 1 showing the distal end of the nozzle with a conical shape.
  • [0043]
    FIG. 8 d) is a cross-sectional end view of the nozzle of FIG. 1 showing the distal end with a rectangular section.
  • [0044]
    FIG. 8 e) is a cross-sectional end view of the nozzle of FIG. 1 showing the distal end of the nozzle with a multiangular section.
  • [0045]
    FIG. 8 f) is a cross-sectional end view of the nozzle of FIG. 1 showing the distal end of the nozzle with an oval section.
  • [0046]
    FIG. 9 a) is a cross-sectional elevation view of the nozzle of FIG. 1 showing the outside shape of the nozzle as a cylinder.
  • [0047]
    FIG. 9 b) is a cross-sectional elevation view of the nozzle of the invention showing the outside of the nozzle as a flared cylinder.
  • [0048]
    FIG. 9 c) is a cross-sectional elevation view of the nozzle of the invention showing the outside of the nozzle having a conical distal end.
  • [0049]
    FIG. 9 d) is a cross-sectional elevation view of the nozzle of the invention showing the outside of the nozzle with a concave distal end.
  • [0050]
    FIG. 9 e) is a cross-sectional elevation view of the nozzle of the invention showing the outside of the nozzle with a double cut profile.
  • [0051]
    FIG. 9 f) is a cross-sectional elevation view of the nozzle of the invention showing the outside of the nozzle with an oval profile.
  • [0052]
    FIG. 10 a) is a cross-sectional elevation view of the nozzle of FIG. 1 showing the distal end of the nozzle with a rectangular cut shape.
  • [0053]
    FIG. 10 b) is a cross-sectional elevation view of the nozzle of FIG. 1 showing the distal end of the nozzle with a cylindrical cut shape.
  • [0054]
    FIG. 10 c) is a cross-sectional elevation view of the nozzle of FIG. 1 showing the distal end of the nozzle with a conical cut shape.
  • [0055]
    FIG. 10 d) is a cross-sectional elevation view of the nozzle of FIG. 1 showing the distal end of the nozzle with a spherical elliptical oval cut shape.
  • [0056]
    FIG. 10 e) is a cross-sectional elevation view of the nozzle of FIG. 1 showing the distal end of the nozzle with a concave cut shape.
  • [0057]
    FIG. 10 f) is a cross-sectional elevation view of the nozzle of FIG. 1 showing the distal end of the nozzle with a convex shape.
  • [0058]
    FIG. 10 g) is a cross-sectional elevation view of the nozzle of FIG. 1 showing the distal end of the nozzle with a double cut shape.
  • [0059]
    FIG. 10 h) is a cross-sectional elevation view of the nozzle of FIG. 1 showing the distal end of the nozzle with a waved cut shape.
  • [0060]
    FIG. 11 is a cross-sectional elevation view of one preferred embodiment of a self destructing disposable nozzle according to the invention.
  • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • [0061]
    The present invention is a device which uses ultrasonic waves to create, direct and deliver liquid spray to a wound surface comprising a nozzle. The nozzle for ultrasound wound treatment includes a nozzle body having a proximal end which can be removably attached to an ultrasound transducer, the distal end of said nozzle body to be adjacent to the ultrasound transducer tip. The nozzle comprises a generally cylindrical main body and a reservoir in which wound treatment liquid/solution is filled and a valve for dispensing and delivering the liquid/solution to the distal end of ultrasound tip.
  • [0062]
    The invention can perhaps be better appreciated from the drawings. A nozzle for ultrasound wound treatment according to the present invention is illustrated in FIG. 1. More particularly, FIG. 1 depicts a cross-sectional view of a side elevation of a preferred embodiment of the nozzle for ultrasound wound treatment, with a main body 10 of the nozzle, a wound treatment liquid/solution reservoir 12, and a retaining wound treatment liquid/solution 14 which is inter-connected via a tube 16, controlled by a valve 18 to deliver a supply of treatment liquid/solution droplets 24 to the distal end of an ultrasound tip 20 of an ultrasound transducer 22. Wound treatment liquid 14 from reservoir 12 is dispensed and delivered by valve 18 to contact distal end of ultrasound tip 20 and spray onto the wound surface.
  • [0063]
    FIGS. 2 a)-d) illustrate possible locations of liquid reservoir 12 relative to nozzle body 10. The preferred location of reservoir 12 is on the top of nozzle body 10, as illustrated in FIG. 2 a), since this arrangement is most convenient, easy to handle and space-saving. Reservoir 12 may optionally be provided with a cover.
  • [0064]
    FIGS. 3 a) and b) depict alternative cross-sectional views of nozzle body 10 and reservoir 12, providing ultrasound tip 20 with liquid/solution directly and through orifice tube 16.
  • [0065]
    FIGS. 4 a)-c), collectively depict side and end elevation views and top views of a three reservoir system for mixing different liquids, drugs, or liquids and gases, for example, saline with oxygen, and treating a wound. Shown are nozzle body 10 and multiple liquid/fluid reservoirs 12, with liquid/fluid treatments 14 being fed via tubes 16 and controlled by valves 18.
  • [0066]
    Gas and liquid can be delivered separately from the top, side and bottom of the distal end of the ultrasound transducer to be mixed and sprayed on the wound surface. This design allows one to mix different liquids and/or liquids with gas, such as saline or an antibiotic with oxygen during wound treatment, without the use of high pressure, which is required with other mixing methods.
  • [0067]
    FIGS. 5 a)-c), collectively depict various locations for the placement of valve 18 between reservoir 12 and tube 16 which delivers liquid/fluid to the distal end of ultrasound transducer tip 20.
  • [0068]
    To avoid liquid loss during dispensing, the distance from valve 18 to the distal end of ultrasound transducer tip 20 should be minimized. This means that valve 18 should be located as close as possible to the distal end of the ultrasound transducer tip 20. For this reason, the most preferred location is as shown in FIG. 5 b).
  • [0069]
    FIG. 6 depicts a cross-sectional elevation view of another preferred embodiment of the nozzle of the invention without valve 18. In this configuration reservoir 12 must be constructed of an elastic material and liquid 14 will be delivered to the ultrasound transducer tip 20 by squeezing the walls of reservoir 12. Reservoir 12 can be rigid, but liquid must the reach the ultrasound tip 20 using a different means.
  • [0070]
    FIG. 7 depicts a cross-sectional elevation view of nozzle body 10 with a trigger 26, which is connected and operates valve 18, thus dispensing and changing liquid flow.
  • [0071]
    FIGS. 8 a)-f), collectively depict various alternative preferred nozzle 10 geometries. The shape of the distal end of nozzle 10 from inside can be cylindrical, as shown in FIG. 8 a), conical, as shown in FIGS. 8 b) and c), (back or forward), rectangular, as shown in FIG. 8 d), multiangular, as shown in FIG. 8 e), elliptic-oval as shown in FIG. 8 f), or a combination of different shapes. The most preferred shape is cylindrical because of the uniform gap created between distal end of nozzle 10 and cylindrical ultrasound tip 20, with this shape.
  • [0072]
    FIGS. 9 a)-f), collectively depict various alternative preferred nozzle 10 geometries from the outside. The shape of the distal end of nozzle 10 from outside can be cylindrical, as shown in FIG. 9 a), conical as depicted in FIGS. 9 b)-c), rectangular as shown in FIG. 9), multiangular as shown in FIG. 9 e), elliptic/oval as shown in FIG. 9 f) or a combination of different shapes.
  • [0073]
    FIGS. 10 a)-h) depict cross-sectional elevational views of the distal end of nozzle showing the different shapes possible, a rectangle as shown in FIG. 10 a), cut cylinder as shown in FIGS. 10 b)-c), spherical/elliptic/oval as shown in FIG. 10 d), concave as shown in FIG. 10 e), convex as shown in FIG. 10 f), double cut as shown in FIG. 10 g), waved as shown in FIG. 10 h) or a combination of different shapes.
  • [0074]
    With reference to FIG. 11, shown is one preferred embodiment of a self-destructing disposable nozzle fabricated from one-piece plastic. A trigger 30 with a needle valve 32 connected with reservoir 12 at a point 34 in closing position. After reservoir 12 is filled with liquid and positioning at the wound, trigger 30 is depressed opening valve 32 by lifting. Because of the rigid connection of trigger 30 to reservoir 12, after pushing trigger 30 gets broken at point 34, and after the first procedure is done, will no longer retain the liquid in reservoir 12. Thus, this becomes a one use disposable reservoir/nozzle arrangement.
  • [0075]
    The preceding specific embodiments are illustrative of the practice of the invention. It is to be understood, however, that other expedients known to those skilled in the art or disclosed herein, may be employed without departing from the spirit of the invention or the scope of the appended claims.
Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US3243122 *Feb 24, 1965Mar 29, 1966Alvin A SnaperUltrasonic spray apparatus
US3392916 *Nov 22, 1966Jul 16, 1968Carl Gunnar Daniel EngstromUltrasonic atomizer
US3433226 *Jul 21, 1965Mar 18, 1969Aeroprojects IncVibratory catheterization apparatus and method of using
US3522801 *Aug 6, 1968Aug 4, 1970Hydrosonic CorpUltrasonic dental hygiene device
US3561444 *May 22, 1968Feb 9, 1971Bio Logics IncUltrasonic drug nebulizer
US3636947 *Dec 3, 1970Jan 25, 1972Ultrasonic SystemsUltrasonic home dental instrument and method
US3860173 *Mar 27, 1974Jan 14, 1975Sata NaoyasuNon-polluting combustion engine having ultrasonic fuel atomizer in place of carburetor
US4085893 *Sep 3, 1976Apr 25, 1978Durley Iii Benton AUltrasonic humidifiers, atomizers and the like
US4153201 *Nov 8, 1976May 8, 1979Sono-Tek CorporationTransducer assembly, ultrasonic atomizer and fuel burner
US4251031 *Jun 22, 1979Feb 17, 1981Plessey Handel Und Investments AgVibratory atomizer
US4271705 *Nov 26, 1979Jun 9, 1981Karl Deutsch Pruf-und MessgerateMethod and device for generating acoustic pulses
US4309989 *Aug 14, 1978Jan 12, 1982The Curators Of The University Of MissouriTopical application of medication by ultrasound with coupling agent
US4319155 *Dec 11, 1979Mar 9, 1982Omron Tateisi Electronics Co.Nebulization control system for a piezoelectric ultrasonic nebulizer
US4334531 *Jun 18, 1980Jun 15, 1982Bosch-Siemens Hausgerate GmbhInhalator
US4428531 *Aug 19, 1980Jan 31, 1984Eaton CorporationMethod of producing a fuel injector
US4466571 *Jun 22, 1982Aug 21, 1984Muehlbauer ReinhardHigh-pressure liquid injection system
US4530360 *Nov 12, 1982Jul 23, 1985Duarte Luiz RMethod for healing bone fractures with ultrasound
US4582654 *Sep 12, 1984Apr 15, 1986Varian Associates, Inc.Nebulizer particularly adapted for analytical purposes
US4642581 *Jun 21, 1985Feb 10, 1987Sono-Tek CorporationUltrasonic transducer drive circuit
US4655393 *Feb 27, 1986Apr 7, 1987Sonotek CorporationHigh volume ultrasonic liquid atomizer
US4659014 *Sep 5, 1985Apr 21, 1987Delavan CorporationUltrasonic spray nozzle and method
US4679551 *Feb 22, 1985Jul 14, 1987Tomtec, N.V.Device for performing therapeutic treatments
US4726523 *Dec 6, 1985Feb 23, 1988Toa Nenryo Kogyo Kabushiki KaishaUltrasonic injection nozzle
US4726525 *May 9, 1986Feb 23, 1988Toa Nenryo Kogyo Kabushiki KaishaVibrating element for ultrasonic injection
US4733820 *Dec 6, 1985Mar 29, 1988Toa Nenryo Kogyo Kabushiki KaishaVibrating element for use on an ultrasonic injection nozzle
US4756478 *Dec 6, 1985Jul 12, 1988Toa Nenryo Kogyo Kabushiki KaishaVibrating element for use on an ultrasonic injection nozzle
US4818697 *Oct 27, 1986Apr 4, 1989Life Resonances, Inc.Techniques for enhancing the permeability of ions through membranes
US4850534 *Apr 19, 1988Jul 25, 1989Tdk CorporationUltrasonic wave nebulizer
US4905671 *Jan 11, 1988Mar 6, 1990Dornier Medizintechnik GmbhInducement of bone growth by acoustic shock waves
US4930700 *Oct 19, 1988Jun 5, 1990Atochem North AmericaUltrasonic dispersion nozzle having internal shut-off mechanism with barrier fluid separation
US4941618 *Jul 7, 1986Jul 17, 1990Leeman Labs Inc.Nebulizer employing a fine mesh screen
US4982730 *Dec 21, 1988Jan 8, 1991Lewis Jr Royce CUltrasonic wound cleaning method and apparatus
US5002059 *Jul 26, 1989Mar 26, 1991Boston Scientific CorporationTip filled ultrasound catheter
US5013241 *Sep 18, 1989May 7, 1991Von Gutfeld Robert JUltrasonic jet dental tool and method
US5040537 *Nov 21, 1988Aug 20, 1991Hitachi, Ltd.Method and apparatus for the measurement and medical treatment using an ultrasonic wave
US5104042 *Mar 29, 1990Apr 14, 1992Atochem North America, Inc.Ultrasonic dispersion nozzle with internal shut-off mechanism having barrier-fluid separation means incorporated therewith
US5115805 *Feb 23, 1990May 26, 1992Cygnus Therapeutic SystemsUltrasound-enhanced delivery of materials into and through the skin
US5186162 *Dec 17, 1990Feb 16, 1993Interpore Orthopaedics, Inc.Ultrasonic transducer device for treatment of living tissue and/or cells
US5197946 *Jul 10, 1991Mar 30, 1993Shunro TachibanaInjection instrument with ultrasonic oscillating element
US5211160 *Mar 19, 1991May 18, 1993Interpore Orthopaedics, Inc.Ultrasonic orthopedic treatment head and body-mounting means therefor
US5309898 *Oct 13, 1993May 10, 1994Kaufman Jonathan JUltrasonic bone-therapy and assessment apparatus and method
US5315998 *Mar 20, 1992May 31, 1994Katsuro TachibanaBooster for therapy of diseases with ultrasound and pharmaceutical liquid composition containing the same
US5316000 *Jan 21, 1992May 31, 1994Technomed International (Societe Anonyme)Use of at least one composite piezoelectric transducer in the manufacture of an ultrasonic therapy apparatus for applying therapy, in a body zone, in particular to concretions, to tissue, or to bones, of a living being and method of ultrasonic therapy
US5318014 *Sep 14, 1992Jun 7, 1994Coraje, Inc.Ultrasonic ablation/dissolution transducer
US5323769 *Aug 2, 1993Jun 28, 1994Cygnus Therapeutic SystemsUltrasound-enhanced delivery of materials into and through the skin
US5324255 *Jul 10, 1992Jun 28, 1994Baxter International Inc.Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm
US5380411 *Dec 2, 1988Jan 10, 1995Schering AktiengesellschaftUltrasound or shock wave work process and preparation for carrying out same
US5393296 *Dec 9, 1992Feb 28, 1995Siemens AktiengesellschaftMethod for the medical treatment of pathologic bone
US5515841 *Nov 21, 1994May 14, 1996Minnesota Mining And Manufacturing CompanyInhaler
US5515842 *Aug 8, 1994May 14, 1996Disetronic AgInhalation device
US5516043 *Jun 30, 1994May 14, 1996Misonix Inc.Ultrasonic atomizing device
US5520166 *Apr 28, 1995May 28, 1996Aradigm CorporationMedication cassette for an automatic aerosol medication delivery system
US5520612 *Dec 30, 1994May 28, 1996Exogen, Inc.Acoustic system for bone-fracture therapy
US5527350 *Feb 24, 1993Jun 18, 1996Star Medical Technologies, Inc.Pulsed infrared laser treatment of psoriasis
US5529572 *Jan 21, 1993Jun 25, 1996Medispec Ltd.Method and apparatus particularly useful for treating osteoporosis
US5616140 *Mar 21, 1994Apr 1, 1997Prescott; MarvinMethod and apparatus for therapeutic laser treatment
US5626554 *Feb 21, 1995May 6, 1997Exogen, Inc.Gel containment structure
US5643179 *Dec 28, 1994Jul 1, 1997Kabushiki Kaisha ToshibaMethod and apparatus for ultrasonic medical treatment with optimum ultrasonic irradiation control
US5707402 *Sep 6, 1996Jan 13, 1998Team Medical, L.L.C.Directed energy surgical method and assembly
US5707403 *Apr 23, 1996Jan 13, 1998Star Medical Technologies, Inc.Method for the laser treatment of subsurface blood vessels
US5730705 *Jun 12, 1996Mar 24, 1998Talish; Roger J.Ultrasonic treatment for bony ingrowth
US5735811 *Nov 30, 1995Apr 7, 1998Pharmasonics, Inc.Apparatus and methods for ultrasonically enhanced fluid delivery
US5743863 *Oct 2, 1996Apr 28, 1998Technomed Medical Systems And Institut NationalHigh-intensity ultrasound therapy method and apparatus with controlled cavitation effect and reduced side lobes
US5752924 *Aug 2, 1996May 19, 1998Orthologic CorporationUltrasonic bone-therapy apparatus and method
US5762616 *Mar 15, 1996Jun 9, 1998Exogen, Inc.Apparatus for ultrasonic treatment of sites corresponding to the torso
US5785972 *Jan 10, 1997Jul 28, 1998Tyler; Kathleen A.Colloidal silver, honey, and helichrysum oil antiseptic composition and method of application
US5879314 *Sep 2, 1997Mar 9, 1999Cybersonics, Inc.Transducer assembly and method for coupling ultrasonic energy to a body for thrombolysis of vascular thrombi
US5879364 *Sep 30, 1997Mar 9, 1999Ethicon Endo-Surgery, Inc.Internal ultrasonic tip amplifier
US5882302 *Jun 24, 1996Mar 16, 1999Ths International, Inc.Methods and devices for providing acoustic hemostasis
US5894841 *Jun 28, 1994Apr 20, 1999Ponwell Enterprises LimitedDispenser
US5904659 *Jul 1, 1997May 18, 1999Exogen, Inc.Ultrasonic treatment for wounds
US6014970 *Jun 11, 1998Jan 18, 2000Aerogen, Inc.Methods and apparatus for storing chemical compounds in a portable inhaler
US6024718 *Sep 4, 1997Feb 15, 2000The Regents Of The University Of CaliforniaIntraluminal directed ultrasound delivery device
US6026808 *Jun 7, 1999Feb 22, 2000Sheffield Pharmaceuticals, Inc.Methods and apparatus for delivering aerosolized medication
US6027495 *Mar 20, 1997Feb 22, 2000Esc Medical Systems Ltd.Method and apparatus for dermatology treatment
US6041253 *Apr 1, 1996Mar 21, 2000Massachusetts Institute Of TechnologyEffect of electric field and ultrasound for transdermal drug delivery
US6061597 *Dec 18, 1998May 9, 2000Robert D. RiemanMethod and device for healing bone fractures
US6076519 *Nov 4, 1996Jun 20, 2000Ethex International, Inc.Passive inspiratory nebulizer system
US6083159 *Jun 4, 1999Jul 4, 2000Ths International, Inc.Methods and devices for providing acoustic hemostasis
US6176839 *Jul 22, 1998Jan 23, 2001Hmt High Medical Technologies AgMethod and system for treatment with acoustic shock waves
US6186963 *Apr 30, 1998Feb 13, 2001Hmt Holding AgDevice for generating acoustic shock waves, especially for medical applications
US6190315 *Jan 8, 1999Feb 20, 2001Sontra Medical, Inc.Sonophoretic enhanced transdermal transport
US6190336 *Mar 19, 1999Feb 20, 2001Exogen, Inc.Ultrasonic treatment for wounds
US6206842 *Aug 3, 1998Mar 27, 2001Lily Chen TuUltrasonic operation device
US6206843 *Jan 28, 1999Mar 27, 2001Ultra Cure Ltd.Ultrasound system and methods utilizing same
US6231528 *Jan 15, 1999May 15, 2001Jonathan J. KaufmanUltrasonic and growth factor bone-therapy: apparatus and method
US6234990 *Jun 30, 1997May 22, 2001Sontra Medical, Inc.Ultrasound enhancement of transdermal transport
US6251099 *Nov 26, 1997Jun 26, 2001The General Hospital CorporationCompound delivery using impulse transients
US6533803 *Dec 22, 2000Mar 18, 2003Advanced Medical Applications, Inc.Wound treatment method and device with combination of ultrasound and laser energy
US6569099 *Jan 12, 2001May 27, 2003Eilaz BabaevUltrasonic method and device for wound treatment
US6723064 *Jun 4, 2003Apr 20, 2004Advanced Medical Applications, Inc.Ultrasonic catheter drug delivery method and device
US6732744 *Dec 7, 2001May 11, 2004The Procter & Gamble CompanyMethod for the ultrasonic treatment of hair and other keratinous fibers
US6761729 *Feb 14, 2003Jul 13, 2004Advanced Medicalapplications, Inc.Wound treatment method and device with combination of ultrasound and laser energy
US7316664 *Mar 12, 2003Jan 8, 2008Advanced Medical Optics, Inc.Modulated pulsed ultrasonic power delivery system and method
US20040030254 *May 23, 2003Feb 12, 2004Eilaz BabaevDevice and method for ultrasound wound debridement
US20060058710 *Sep 22, 2005Mar 16, 2006Eilaz BabaevUltrasound wound treatment method and device using standing waves
US20070016110 *Jun 27, 2005Jan 18, 2007Eilaz BabaevRemovable applicator nozzle for ultrasound wound therapy device
US20070088245 *Jun 23, 2006Apr 19, 2007Celleration, Inc.Removable applicator nozzle for ultrasound wound therapy device
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US7713218Jun 27, 2005May 11, 2010Celleration, Inc.Removable applicator nozzle for ultrasound wound therapy device
US7785277Jun 23, 2006Aug 31, 2010Celleration, Inc.Removable applicator nozzle for ultrasound wound therapy device
US7830070Feb 12, 2008Nov 9, 2010Bacoustics, LlcUltrasound atomization system
US7842249Dec 21, 2007Nov 30, 2010Bacoustics, LlcApparatus for vaccine development using ultrasound technology
US7846341Dec 4, 2006Dec 7, 2010Bacoustics, LlcMethod of ultrasonically treating a continuous flow of fluid
US7914470Apr 1, 2004Mar 29, 2011Celleration, Inc.Ultrasonic method and device for wound treatment
US7943352Mar 29, 2006May 17, 2011Bacoustics, LlcApparatus and methods for vaccine development using ultrasound technology
US7947010 *Jul 5, 2006May 24, 2011Depuy Products, Inc.Composition and system for wound decontamination
US7950594Feb 11, 2008May 31, 2011Bacoustics, LlcMechanical and ultrasound atomization and mixing system
US8016208Feb 8, 2008Sep 13, 2011Bacoustics, LlcEchoing ultrasound atomization and mixing system
US8050752Sep 29, 2006Nov 1, 2011Bacoustics, LlcMethod of treating lumens, cavities, and tissues of the body with an ultrasound delivered liquid
US8235919Apr 7, 2003Aug 7, 2012Celleration, Inc.Ultrasonic method and device for wound treatment
US8357115Apr 18, 2011Jan 22, 2013Depuy Products, Inc.Composition and system for wound decontamination
US8491521Jul 17, 2008Jul 23, 2013Celleration, Inc.Removable multi-channel applicator nozzle
US9242049 *Jun 13, 2012Jan 26, 2016Sono-Tek CorporationUltrasonic suspension delivery system
US20030236560 *Apr 7, 2003Dec 25, 2003Eilaz BabaevUltrasonic method and device for wound treatment
US20040186384 *Apr 1, 2004Sep 23, 2004Eilaz BabaevUltrasonic method and device for wound treatment
US20070009505 *Jul 5, 2006Jan 11, 2007Arscott Edward F IiComposition and system for wound decontamination
US20070016110 *Jun 27, 2005Jan 18, 2007Eilaz BabaevRemovable applicator nozzle for ultrasound wound therapy device
US20070088245 *Jun 23, 2006Apr 19, 2007Celleration, Inc.Removable applicator nozzle for ultrasound wound therapy device
US20080082039 *Sep 29, 2006Apr 3, 2008Eilaz BabaevUltrasound Liquid Delivery Device
US20080095920 *Dec 18, 2007Apr 24, 2008Eilaz BabaevUltrasound medical device coating method
US20080119779 *Sep 29, 2006May 22, 2008Eilaz BabaevMethod of Treating Lumens, Cavities, and Tissues of the Body with an Ultrasound Delivered Liquid.
US20080128362 *Dec 4, 2006Jun 5, 2008Bacoustics LlcMethod of ultrasonically treating a continuous flow of fluid
US20080177221 *Dec 21, 2007Jul 24, 2008Celleration, Inc.Apparatus to prevent applicator re-use
US20080214965 *Jan 4, 2008Sep 4, 2008Celleration, Inc.Removable multi-channel applicator nozzle
US20080243047 *Mar 27, 2007Oct 2, 2008Babaev Eilaz PUltrasound wound care device
US20090024076 *Jul 7, 2008Jan 22, 2009Celleration, Inc.Nozzle for ultrasound wound treatment
US20090043248 *Jul 17, 2008Feb 12, 2009Celleration, Inc.Removable multi-channel applicator nozzle
US20090177122 *Dec 23, 2008Jul 9, 2009Celleration, Inc.Methods for treating inflammatory skin disorders
US20090177123 *Dec 23, 2008Jul 9, 2009Celleration, Inc.Methods for treating inflammatory disorders
US20090200390 *Feb 12, 2008Aug 13, 2009Eilaz BabaevUltrasound atomization system
US20090200396 *Feb 11, 2008Aug 13, 2009Eilaz BabaevMechanical and ultrasound atomization and mixing system
US20100022919 *Jul 22, 2009Jan 28, 2010Celleration, Inc.Methods of Skin Grafting Using Ultrasound
US20110196319 *Apr 18, 2011Aug 11, 2011Arscott Ii Edward FComposition and system for wound decontamination
US20110230795 *Mar 28, 2011Sep 22, 2011Eilaz BabaevUltrasonic method and device for wound treatment
US20120241478 *Jun 13, 2012Sep 27, 2012Sono-Tek CorporationUltrasonic Suspension Delivery System
USD733319Jan 10, 2014Jun 30, 2015Celleration, Inc.Ultrasonic treatment wand
USD733321Jan 10, 2014Jun 30, 2015Celleration, Inc.Ultrasonic treatment device
WO2008042669A1 *Sep 26, 2007Apr 10, 2008Eilaz BabaevUltrasound liquid delivery device and methods of using ultrasonic energy to deliver liquids into the body
Classifications
U.S. Classification604/22, 604/82
International ClassificationA61B17/20, A61M35/00, A61M11/00, A61N7/00
Cooperative ClassificationA61M35/00, A61N7/00, A61M11/005, A61M2205/058, A61M11/001
European ClassificationA61M35/00, A61M11/00F, A61N7/00
Legal Events
DateCodeEventDescription
Mar 30, 2007ASAssignment
Owner name: CELLERATION, INC., MINNESOTA
Free format text: MERGER;ASSIGNOR:CELLERATION, INC.;REEL/FRAME:019094/0591
Effective date: 20030506
Owner name: CELLERATION, INC., MINNESOTA
Free format text: CHANGE OF NAME;ASSIGNOR:ADVANCED MEDICAL APPLICATIONS, INC.;REEL/FRAME:019102/0655
Effective date: 20020730
Feb 7, 2008ASAssignment
Owner name: ADVANCED MEDICAL APPLICATIONS, INC., MINNESOTA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BABAEV, EILAZ;REEL/FRAME:020474/0080
Effective date: 20011031