US 20060052736 A1
A transmyocardial implant establishes a blood flow path through a myocardium between a heart chamber and a lumen of a coronary vessel residing on an exterior of the heart. The implant includes a coronary portion sized to be received within the vessel. A myocardial portion is sized to pass through the myocardium into the heart chamber. A transition portion connects the coronary and myocardial portions for directing blood flow from the myocardial portion to the coronary portion. The coronary portion and the myocardial portion have an open construction for permitting tissue growth across a wall thickness of the coronary portion and the myocardial portion. The myocardial portion includes an agent for controlling a coagulation cascade and platelet formation.
18. A method for supporting a wall of a vascular structure at an area adjacent an incision in the wall of the vascular structure, the method comprising steps of:
inserting a support through the incision in the wall of the vascular structure while the support is in a low profile orientation;
positioning at least a portion of the support within the interior of the vascular structure; and
moving the support from the low profile orientation into an expanded orientation so as to contact and support the wall of the vascular structure.
19. The method of
20. The method of
21. A conduit for placing a coronary vessel of a patient's heart in communication with a heart chamber, the conduit comprising:
a tubular element configured to positioned in the wall of a patient's heart, the tubular element including first and second ends and a bore defining a blood flow path; and
a vessel supporting mechanism carried by the tubular element, the vessel supporting mechanism being positioned on the conduit so as to contact and support the wall of a coronary vessel when the conduit is positioned in the heart wall.
22. The conduit of
23. The conduit of
24. A method for promoting angiogenesis within the tissue of a muscle, comprising:
accessing the muscle with a delivery system,
penetrating the muscle,
releasing within the muscle at least one flexible body dimensionally adapted for implantation within the muscle, said body having been subjected to deforming stress prior to its release within the muscle and said body dynamically approximating the recovery of its native configuration after its implantation, and
withdrawing the delivery system from its proximity to the muscle.
25. A kit for promoting angiogenesis within a muscle comprising:
a delivery system for accessing the muscle,
an implantable body dimensionally adapted for being enclosed within the tissues of the muscle, and
an implantation device capable of inserting the implantable body within the muscle,
whereby the placement of the implantable body within the tissues of the muscle promotes angiogenesis.
26. Apparatus for promoting angiogenesis comprising:
a body formed of a biocompatible material and being dimensionally adapted for implantation within tissues of a muscle, said body having at least one surface carrying a substance capable of promoting localized angiogenesis.
27. Apparatus according to
28. Apparatus according to
29. Apparatus according to
30. Apparatus according to
31. Apparatus according to
32. Apparatus for promoting angiogenesis, comprising:
a body formed of a biocompatible material and being dimensionally adapted for implantation within the tissue of a muscle, said body being configured as a scaffold that provides support for tissue ingrowth, whereby said body promoting tissue ingrowth to thereby stimulate angiogenesis.
33. Apparatus according to
34. Apparatus according to
1. Field of the Invention
This invention pertains to an implant for passing blood flow directly between a chamber of the heart and a coronary vessel. More particularly, this invention pertains to such an implant with an enhance design for promoting a healed layer of cells on an interior of the implant.
2. Description of the Prior Art
Commonly assigned U.S. Pat. No. 5,755,682 issued May 26, 1998 and commonly assigned and co-pending U.S. patent application Ser. No. 08/882,397 filed Jun. 25, 1997, entitled “Method and Apparatus for Performing Coronary Bypass Surgery”, and filed in the name of inventors Mark B. Knudson and William L. Giese (published as PCT International Application Publication No. WO 98/06356) both teach an implant for defining a blood flow conduit directly from a chamber of the heart to a lumen of a coronary vessel. In one embodiment, an L-shaped implant is received within a lumen of a coronary artery and passed through the myocardium to extend into the left ventricle of the heart. The conduit is rigid and remains open for blood flow to pass through the conduit during both systole and diastole. The conduit penetrates into the left ventricle in order to prevent tissue growth and occlusions over an opening of the conduit. The '682 patent and '397 application also describe an embodiment where a portion of the implant passing through the heart wall is an open structural member lined by polyester (e.g., Dacron). A further embodiment discloses a portion of the implant in a coronary vessel as being an open cell, balloon-expandable stent.
U.S. Pat. No. 5,429,144 to Wilk dated Jul. 4, 1995 teaches implants which are passed through the vasculature in a collapsed state and expanded when placed in the myocardium so as not to extend into either the coronary artery or the left ventricle. The described implants close once per cycle of the heart (e.g., during diastole in the embodiment of
Commonly assigned and co-pending U.S. patent application Ser. No. 08/944,313 filed Oct. 6, 1997, entitled “Transmyocardial Implant”, and filed in the name of inventors Katherine S. Tweden, Guy P. Vanney and Thomas L. Odland, teaches an implant such as that shown in the aforementioned '397 application and '682 patent with an enhanced fixation structure. The enhanced fixation structure includes a fabric surrounding at least a portion of the conduit to facilitate tissue growth on the exterior of the implant.
PCT International Application Publication No. WO 98/08456 describes a protrusive stent to form a passageway from the heart to a coronary vessel. The stent is described as wire mesh or other metal or polymeric material and may be self-expanding or pressure expandable. The application describes the stent may be covered by a partial or complete tubular covering of material including polyester, woven polyester, polytetraflouroethylene, expanded polytetraflouroethylene, polyurethane, silicone, polycarbonate, autologous tissue and xenograft tissue.
Biocompatibility is an important design feature. Solid metal implants are formed of material (e.g., titanium or pyrolytic carbon) with low incidents of thrombus and platelet activation. While such materials are proven in use in a wide variety of products (e.g., heart valve components), they do not facilitate full healing. By “healing”, it is meant that over time, the patient's cells grow over the material of the implant so that blood flowing through the implant is exposed only (or at least primarily) to the patient's cells rather than to a foreign material.
According to a preferred embodiment of the present invention, a transmyocardial implant is disclosed for establishing a blood flow path through a myocardium between a heart chamber and a lumen of a coronary vessel residing on an exterior of the heart. The implant includes a coronary portion sized to be received with the vessel. A myocardial portion is sized to pass through the myocardium into the heart chamber. A transition portion connects the coronary and myocardial portions for directing blood flow from the myocardial portion and into the coronary portion. The coronary portion and the myocardial portion have an open construction for permitting tissue growth across a wall thickness of the coronary portion and the myocardial portion. The myocardial portion includes an agent for controlling the coagulation cascade and platelet activation, and promoting healing.
With initial reference to
The tube 10 has a coronary portion 12 sized to be received within the lumen of a coronary vessel such as the lumen 80 of a coronary artery 82 distal to an obstruction 81 as illustrated in
The coronary portion 12 has a first opening 16. The myocardial portion 14 has a second opening 18 in communication with an interior 20 of the implant 10. Therefore, blood can freely flow through the implant 10 between the left ventricle 83 and the lumen 80 of the coronary artery 82. Blood flows axially out of opening 16 parallel with the axis of lumen 80.
The longitudinal axis of the coronary portion 12 is aligned with the axis of the lumen 80. Sutures 24 secure the artery 82 to the coronary portion 12. The proximal portion 82 a of the coronary artery is ligated by sutures 85.
The coronary and myocardial portions 12, 14 have an open lattice construction 12 a, 14 a to define a plurality of open cells 12 b, 14 b extending through the wall thickness of the implant 10. Preferably, the coronary and myocardial portions 12, 14 are joined by a transition portion 13 in a 90° bend between portions 12, 14. While transition portion 13 can have an open lattice construction as portions 12, 14, transition portion 13 will preferably have smaller open areas in such an open construction or, as illustrated, will be of solid construction. Such construction permits the transition portion to deflect high velocity blood flows from the myocardial portion 14 into the coronary portion 12. A lattice construction with large open cells in the transition portion could result in the high velocity flow damaging tissue (not shown) overlying the transition portion.
Any one or all of the coronary portion 12, transition portion 13 and myocardial portion 14 could be formed in final size as rigid units or could be formed in small diameter sizes which are subsequently expanded to full size. For example,
In either percutaneous or surgical implants, a flexible transition portion 13 (as would be achieved with a stent lattice construction) permits relative articulation between the coronary and myocardial portions 12, 14 to ensure the coronary portion is axially aligned with the lumen 80. Absent such articulation, such axial alignment is achieved by accurately controlling the position of the myocardial portion 14 such that the coronary portion 12 is axially aligned with the lumen 80 following implantation.
The open cell construction of the coronary and myocardial portions 12, 14 permit tissue growth through the open cells 12 c, 14 c following implant. The healing procedure in the coronary portion 12 is the same as that in coronary stents. Vascular endothelial cells grow over to coat the structural material 12 a of portion 12.
In portion 14, myocardial tissue, if not obstructed, will grow through the cells 14 c. Furthermore, the myocardium is highly thrombogenic. Therefore, uncontrolled contact between the myocardium 82 and the implant interior 20 can result in thrombosis of the implant 10. Further, it is believed that the epicardium (i.e., outer layer of the myocardium) has a greater density of myocardial growth cells which contribute to healing.
To control growth in the myocardial portion 14, a liner 30 is provided in the myocardial portion 14. The liner 30 is any porous material for accepting tissue growth and, preferably, is a polyester fabric (e.g., Dacron). The porous liner 30 has interstial spaces smaller than the open cells 12 c, 14 c. The liner 30 is shown on an interior of the myocardial portion 14 but could also or alternatively surround the exterior.
The liner 30 has an upper end 32 secured through any suitable means (e.g., sutures not shown) to the upper end of the myocardial portion 14. A lower end 34 is folded over the opening of the myocardial portion 14 and secured to the exterior of the portion 14 by sutures 36. The myocardial portion 14 is sized to protrude into the left ventricle 83 with only the folded over liner material exposed to the interior of the left ventricle 83.
The liner 30 acts as a porous substrate into which tissue may grow. To prevent thrombus, the liner 30 is impregnated with an agent for controlling coagulation cascade and platelet activation and adhesion. An example of such an agent is heparin but could be any anticoagulant or anti-platelet. Also, an agent such as a basic fibroblast growth factor could be used to accelerate healing.
The agent permits structural cells to grow on the liner by limiting thrombus formation which, uncontrolled, would occlude the implant. Due to the open construction, the structural, healing cells of the epicardium can grow onto the liner. Subsequently, endothelial cells can grow on the structural cells.
Therefore, the structure described promotes a three-stage healing process:
In the transition portion 13, an open cells structure will permit tissue growth as in the coronary portion 12. Such growth may also occur in the solid construction. Alternatively, the liner 30 can be extended into the transition portion 13. Additionally, the open cell structure in the transition portion 13 can permit articulation between the coronary portion and the myocardial portion. Such a structure is shown in
Having disclosed the present invention in a preferred embodiment, it will be appreciated that modifications and equivalents may occur to one of ordinary skill in the art having the benefits of the teachings of the present invention. It is intended that such modifications shall be included within the scope of the claims appended hereto. For example, the liner 30 can take many constructions including PTFE, expanded-PTFE, polyurethane, polypropylene or any biologically compatible paving material or natural tissue. Further, restenosis of the coronary portion 12 can be prevented with radioactivity therapy (such as providing the coronary portion with a short half-life beta emitter). Also, the liner 30 may be either a resorbable or non-resorbable material. Genetically engineered cells can be transformed to secrete anticoagulants and other agents to keep the blood fluid (such as tissue plasminogen activator and smooth muscle cells altered to express nitric acid).