|Publication number||US20060058710 A1|
|Application number||US 11/232,801|
|Publication date||Mar 16, 2006|
|Filing date||Sep 22, 2005|
|Priority date||Jan 30, 2001|
|Also published as||CA2436812A1, DE60232304D1, EP1355696A2, EP1355696A4, EP1355696B1, US6960173, US20020103448, WO2002060525A2, WO2002060525A3|
|Publication number||11232801, 232801, US 2006/0058710 A1, US 2006/058710 A1, US 20060058710 A1, US 20060058710A1, US 2006058710 A1, US 2006058710A1, US-A1-20060058710, US-A1-2006058710, US2006/0058710A1, US2006/058710A1, US20060058710 A1, US20060058710A1, US2006058710 A1, US2006058710A1|
|Original Assignee||Eilaz Babaev|
|Export Citation||BiBTeX, EndNote, RefMan|
|Referenced by (13), Classifications (6), Legal Events (2)|
|External Links: USPTO, USPTO Assignment, Espacenet|
The present invention relates to the treatment of wounds using ultrasound standing waves. In particular, the present invention relates to a method and device of creating ultrasonic standing waves in air and directing them to a wound for delivering aerodynamic forces as ultrasonic radiation pressure and ultrasonic waves as well. Ultrasound radiation pressure increases the blood flow in the wound area, and ultrasound waves kill bacteria, stimulate healthy tissue cells, and treat the wound.
Ultrasonic waves have been widely used in medical applications, including diagnostics and therapy as well as many industrial applications, e.g., welding, cutting, fiber optics technology, speed meters, etc. Diagnostic use of ultrasound waves includes using ultrasonic waves to detect underlying structures in an object or human tissue. In this method, an ultrasonic transducer is placed in contact with the tissue or object via a coupling medium, and high frequency (1-10 MHz) ultrasonic waves are directed into the tissue. Upon contact with the various underlying structures, the waves are reflected back to a receiver adjacent the transducer. By comparison of the signals of the ultrasonic waves sent with the reflected ultrasonic wave as received, an image of the underlying structure can be produced. This technique is particularly useful for identifying boundaries between components of tissue and can be used to detect irregular masses, tumors, etc.
Three therapeutic medical uses of ultrasound waves include aerosol mist production, contact physiotherapy, and soft tissue ablation. The ultrasound contact physiotherapy procedure may cause a patient significant discomfort and/or pain, and skin may appear raw and damaged. Aerosol mist production makes use of a nebulizer or inhaler to produce an aerosol mist for creating a humid environment and delivering drugs to the lungs.
Ultrasonic nebulizers operate by passing ultrasound waves of sufficient intensity through a liquid, the waves being directed at an air-liquid interface of the liquid from a point underneath or within the liquid. Liquid particles are ejected from the surface of the liquid into the surrounding air following the disintegration of capillary waves produced by the ultrasound. This technique can produce a very fine dense fog or mist.
Aerosol mists produced by ultrasound are preferred because a smaller particle size of the aerosol can be obtained with the ultrasonic waves. One of the major shortcomings of ultrasonic inhalers and nebulizers is that there is no directed aerosol to the target. An air stream is then required to direct the aerosol to the target, but this decreases the efficiency of ultrasound.
Ultrasonic sprayers (Sonic and Materials Inc., Misonix Inc., Sono-Tek Inc., Zevex International, Inc., operate by passing liquid trough central orifice of ultrasound instrument-tip. See, for example, U.S. Pat. Nos. 3,765,606; 4,659,014; 5,104,042; 4,9307,00; 4,153,201; 4,655,393; 5,516,043; 5,835,678; 5,879,364; and 5,843,139.
Ultrasonic inhalers and drug delivery systems from Medisonic USA, Inc., 3M, Siemens Gmb, The Procter & Gamble Company, Sheffield Pharmaceuticals, Aradigm, Inc., operate by atomizing liquid using piezoceramic film. See, for example, U.S. Pat. Nos. 4,294,407; 5,347,998; 5,520,166; 5,960,792; 6,095,141; 6,102,298; 6,098,620; 6,026,808; and 6,106,547.
It is an object of the invention to provide an improved method and device for treating wounds.
It is also an object of this invention to provide an improved method and device for treating wounds using ultrasound standing waves.
It is a further object of the invention to provide a method and device for increasing blood flow, killing bacteria, and stimulating healthy tissue cell growth.
These and other objects of the invention will become more apparent from the discussion below.
The present invention is a method and device for using ultrasonic standing waves to treat wounds. Ultrasound standing waves occur as a result of incident and reflected waves from a reflective surface that are traveling in opposite directions. The resultant superposition of the two waves forms standing waves, which create ultrasonic radiation pressure. The standing waves, actually ultrasound radiation pressure, occur when the distance between (a) the distal end of a transducer (as a radiant of ultrasound waves) and (b) the reflected surface (e.g., a wound surface) is: n X λ/2, where λ is the wave length and n is a positive integer. The standing waves are more effective in limited space or area as a tube.
According to the invention ultrasound waves are created, directed, and delivered to a wound surface through the air to increase blood flow, kill bacteria, stimulate healthy tissue cells and treat wounds with ultrasound energy. The method of treating wounds involves the use of ultrasound standing waves of a continuous or pulsed ultrasound.
More particularly, the method of the invention comprises producing ultrasound standing waves using a free end surface of an ultrasonic transducer and wound surface.
According to the method of the present invention, the radiation pressure of ultrasonic standing waves increase blood flow in wound area and destroy the surface bacteria to result in a higher disinfecting property of ultrasound. Additionally, the ultrasound also stimulates healthy cell growth to aid in granulization and epithelization of the healing tissue. Other applications of the method can be directed to non-medical uses such as cleansing, drying, sterilizing and coating surfaces of objects and food.
The method of the present invention offers an approach that may re-establish use of some traditional ultrasound and establish a method of treating wound and fighting bacteria without antibiotics when necessary.
The overall concept of the present invention relates in method and apparatus for wound treatment using ultrasonic standing waves through air with no drug. This wound treatment method is possible with combination of different energy sources as an ultrasound, laser, electric current, magnetic field, ultraviolet, microwaves, radio frequency, etc.
The present invention is a method and system, which uses ultrasound standing wave energy to treat wounds. The system comprises a generator of electrical signals and a handpiece having an ultrasound transducer and tip.
The invention can perhaps be better appreciated from the drawings. A system for wound treatment according to present invention is illustrated in
Standing ultrasound waves 14 occur when activated ultrasound tip 12 is directed through the air to a wound surface 16 as a result of incident and reflected waves from wound surface 16, which creates ultrasonic radiation pressure. The distal end 20 of transducer tip 12 (as a radiant of ultrasound waves) is preferably a distance d from wound surface 16 (a source of reflected waves). Distance d is related to the wavelength k of the ultrasound wave or signal by the formula
where n is a positive integer. To reach this preferred distance and therefore effect wound treatment practice, ultrasound transducer 8 or tip 12 must frequently be moved back and forward toward wound surface 16 by an operator.
The waveform of the ultrasound waves generated by transducer 8 preferably corresponds to the waveform of the electrical signals generated by signal generator 4. For example, electrical signals from signal generator 4 with rectangular, sinusoidal, trapezoidal, or triangular waveforms will cause transducer 8 to produce respective similarly shaped ultrasound waveforms.
The standing waves are more effective in limited space or area such as a tube. In each of FIGS. 3 to 5 a bushing 26 increases ultrasound radiation pressure. Bushing 26 may or may not be disposable part on the distal end 28 of housing 10.
In the embodiment of the invention set forth in
One of the possible applications of the method of present invention is the facilitation of dissolution of blood clots by using ultrasound energy. In
In another embodiment of the present invention a wound can also be treated with a gel or drug. After the gel or drug is applied to the wound surface, ultrasound standing waves would be directed to the wound. The drug would be activated and penetrate into tissue under ultrasound radiation pressure.
Additional possible application of method using ultrasound standing waves is for the diffusion of grafts to a wound with radiation pressure gently.
It is provided that the ultrasound transducer operates at a frequency from 10 kHz to 10,000 MHz and the distance d is at least 0.1 inch.
The preceding specific embodiments are illustrative of the practice of the invention. It is to be understood, however, that other expedients known to those skilled in the art or disclosed herein may be employed without departing from the spirit of the invention or the scope of the appended claims.
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US7713218||Jun 27, 2005||May 11, 2010||Celleration, Inc.||Removable applicator nozzle for ultrasound wound therapy device|
|US7785277||Jun 23, 2006||Aug 31, 2010||Celleration, Inc.||Removable applicator nozzle for ultrasound wound therapy device|
|US7830070||Feb 12, 2008||Nov 9, 2010||Bacoustics, Llc||Ultrasound atomization system|
|US7842249||Dec 21, 2007||Nov 30, 2010||Bacoustics, Llc||Apparatus for vaccine development using ultrasound technology|
|US7846341||Dec 4, 2006||Dec 7, 2010||Bacoustics, Llc||Method of ultrasonically treating a continuous flow of fluid|
|US7878991||Aug 31, 2007||Feb 1, 2011||Bacoustics, Llc||Portable ultrasound device for the treatment of wounds|
|US7914470||Apr 1, 2004||Mar 29, 2011||Celleration, Inc.||Ultrasonic method and device for wound treatment|
|US7943352||Mar 29, 2006||May 17, 2011||Bacoustics, Llc||Apparatus and methods for vaccine development using ultrasound technology|
|US7950594||Feb 11, 2008||May 31, 2011||Bacoustics, Llc||Mechanical and ultrasound atomization and mixing system|
|US8016208||Feb 8, 2008||Sep 13, 2011||Bacoustics, Llc||Echoing ultrasound atomization and mixing system|
|US20040186384 *||Apr 1, 2004||Sep 23, 2004||Eilaz Babaev||Ultrasonic method and device for wound treatment|
|USD733319||Jan 10, 2014||Jun 30, 2015||Celleration, Inc.||Ultrasonic treatment wand|
|USD733321||Jan 10, 2014||Jun 30, 2015||Celleration, Inc.||Ultrasonic treatment device|
|International Classification||A61B18/00, A61N7/00, A61H1/00|
|Mar 30, 2007||AS||Assignment|
Owner name: CELLERATION, INC., MINNESOTA
Free format text: CHANGE OF NAME;ASSIGNOR:ADVANCED MEDICAL APPLICATIONS, INC.;REEL/FRAME:019102/0655
Effective date: 20020730
Owner name: CELLERATION, INC., MINNESOTA
Free format text: MERGER;ASSIGNOR:CELLERATION, INC.;REEL/FRAME:019094/0591
Effective date: 20030506
|Feb 7, 2008||AS||Assignment|
Owner name: ADVANCED MEDICAL APPLICATIONS, INC., MINNESOTA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BABAEV, EILAZ;REEL/FRAME:020474/0061
Effective date: 20011031