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Publication numberUS20060167549 A1
Publication typeApplication
Application numberUS 11/388,164
Publication dateJul 27, 2006
Filing dateMar 22, 2006
Priority dateJan 30, 2001
Also published asCA2436243A1, CA2436243C, CN1287752C, CN1482890A, DE50109908D1, EP1355593A1, EP1355593B1, US7044972, US20040082999, WO2002060356A1
Publication number11388164, 388164, US 2006/0167549 A1, US 2006/167549 A1, US 20060167549 A1, US 20060167549A1, US 2006167549 A1, US 2006167549A1, US-A1-20060167549, US-A1-2006167549, US2006/0167549A1, US2006/167549A1, US20060167549 A1, US20060167549A1, US2006167549 A1, US2006167549A1
InventorsRobert Mathys, Beat Lechmann, Beat Gasser
Original AssigneeSynthes Ag Chur And Synthes (Usa)
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Bone implant, in particular, an inter-vertebral implant
US 20060167549 A1
Abstract
A bone implant and the method of manufacturing thereof, the bone implant, in particular an inter-vertebral implant, made of a radiation-permeable material. The inter-vertebral implant defining a surface and comprising a front section, a back section, two lateral sections defining a central axis, and a substantially hollow interior chamber, each section having a superior and inferior vertebral contacting surface. The hollow chamber is subdivided by at least two partitions running essentially parallel to the central axis and which connect the front section to the back section.
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Claims(19)
1. An inter-vertebral implant, comprising:
a front section, a back section, two lateral sections defining a central axis, and a substantially hollow interior chamber, each section having a superior and inferior vertebral contacting surface,
wherein the implant is subdivided by at least two partitions, the at least two partitions running essentially parallel to the central axis and connecting the front section to the back section, and
wherein the implant is made of a radiation-permeable material, the radiation-permeable material exhibits low water absorption.
2. The bone implant of claim 1, wherein the partitions are trussed together by a cross strut.
3. The bone implant of claim 1, wherein each of the two lateral sections have at least one perforation having a minimum area of about 3.5 mm2.
4. The bone implant of claim 3, wherein the perforations of the two lateral sections are at least partially filled with an X-ray-opaque filler material.
5. The bone implant of claim 1, wherein the perforations of the partitions are at least partially filled with an X-ray-opaque filler material.
6. The bone implant of claim 1, wherein the radiation-permeable material is formed from at least one of the group selected from the group consisting of polyarylether ketone (PAEK), polytherimide (PEI), polyoxymethylene (POM), liquid-crystal polymer (LCP), polymethyl pentene (PMP), polysolfone (PSU), polyether sulfone (PESU or PES), polyethylene terephthalate (PETP), polymethyl methacrylate (PMMA), and ultra-high molecular polyethylene (UHMW-PE).
7. The bone implant of the claim 1, wherein the radiation-permeable material is strengthened with fibers, the fibers being selected from at least one of the group consisting of carbon fibers, glass fibers, and PEEK fibers.
8. The bone implant of claim 1 having a total volume, V, and the hollow chamber having a volume, v, and wherein the ratio of V:v between the total volume V of the bone implant and the volume v of the hollow chamber is about 2.1.
9. The bone implant of claim 1, wherein at least a portion of the surface has a thin coating having substantially no effect on the X-ray-transparency.
10. The bone implant of claim 9, wherein the coating is made of a metal, the metal comprising at least one of the group consisting of titanium, gold, and platinum.
11. The bone implant of claim 9, wherein the coating is made of hydroxyapatite or tricalcium phosphate.
12. The bone implant of claim 1, wherein the hollow chamber is at least partially filled with a filler selected from at least one of the group consisting of calcium sulfate, demineralized bone, autologous bone, and coralline substances.
13. The bone implant of claim 1, wherein the hollow chamber is filled at least partially with a filler comprising a resorbable polymer.
14. The bone implant of claim 13, wherein the polymer is substantially porous.
15. An inter-vertebral bone implant, having a total volume V comprising:
a front section, a back section, two lateral sections defining a central axis, and a substantially hollow interior chamber, each section having a superior and inferior vertebral contacting surface,
wherein the hollow chamber being subdivided by at least two partitions, the at least two partitions running essentially parallel to the central axis and connecting the front section to the back section, the at least two partitions trussed together by a cross strut, and
wherein the hollow chamber having a volume, v, and wherein the ratio of V:v between the total volume V of the implant and the volume v of the hollow chamber is about about 2.1.
16. The bone implant of claim 15, wherein the two lateral sections have at least one perforation.
17. The bone implant of claim 16, wherein the perforations have a minimum area of about 3.5 mm2.
18. The bone implant of the claim 15, wherein the radiation-permeable material is strengthened with fibers.
19. The bone implant of claim 15, wherein at least a portion of the surface has a substantially X-ray-transparent coating.
Description
    CROSS-REFERENCE TO RELATED APPLICATIONS
  • [0001]
    This application is a continuation of application Ser. No. 10/629,694, filed Jul. 30, 2003, which is a continuation of International Patent Application No. PCT/CH01/00069, filed Jan. 30, 2001, the entire contents of each of which are expressly incorporated herein by reference thereto.
  • BACKGROUND OF THE INVENTION
  • [0002]
    The present invention is directed to a bone implant, in particular an inter-vertebral implant as well as a method for producing the same.
  • [0003]
    Some of the disadvantages of bone implants known in the art are that: (i) the smooth surfaces of the top and bottom surface areas of the implant or those that are equipped with macroscopic serrations in contact with the base plates of the adjacent vertebrae, do not permit an optimal bone tissue growth; and (ii) where any bone growth filler is located in the hollow body of the implant, the filling easily comes out because of the smooth inner walls of the hollow body of the implant. Two publications disclosing bone implants having such characteristics are WO00/66045 to MICHELSON which is more specifically directed to spinal fusion implants with opposed locking screws and French Application 2 703 580 to ROBERT, is another type of bone implant, specifically directed to an intersomatic cervical cage.
  • SUMMARY OF THE INVENTION
  • [0004]
    The bone implant according to the present invention is directed to an inter-vertebral implant comprising a front section, a back section, two lateral sections which define a cylindrical or central axis, and a substantially hollow interior chamber, each section having a superior and inferior vertebral contacting surface. The implant may be subdivided by at least two partitions that run essentially parallel to the cylindrical axis and connect the front section to the rear section of the sleeve so as to further define superior and inferior support areas. The implant may be made from radiation-permeable material, the radiation-permeable material exhibits low water absorption.
  • [0005]
    In one embodiment of the bone implant, the partitions are trussed together by a cross strut or brace. Moreover, in a preferred embodiment, the lateral sections of the sleeve of the hollow body may have one or more perforations which preferably have a minimum surface area of 3.5 mm2. The perforations in the lateral sections are at least partially filled with an X-ray-opaque filler material.
  • [0006]
    The radiation-permeable material may be selected from the following group: polyarylether ketone (PAEK), polyetherimide (PEI), polyoxymethylene (POM), liquid-crystal polymer (LCP), polymethyl pentene (PMP), polysulfone (PSU), polyether sulfone (PESU or PES), polyethylene terephthalate (PETP), polymethyl methacrylate (PMMA), or ultra-high molecular weight polyethylene (UHMW-PE). All of these materials are elastic, but have various mechanical properties such as elasticity (stiffness) in addition to strength compared to other polymers, they sometimes have favorable creep properties or exhibit low water absorption. Moreover, the bone implant may be fiber-reinforced or strengthened with fibers. In yet another preferred embodiment, the fibers may be carbon fibers, glass fibers, or PEEK fibers.
  • [0007]
    In another embodiment of the bone implant, the ratio V:v between the total volume V of the bone implant and the volume v of the hollow body is 2.1. Moreover, the hollow body may be at least partially filled with a material made of calcium phosphate, preferably hydroxyapatite or alternatively tricalcium phosphate. In addition, the body, may be at least partially filled with material made of calcium sulfate, demineralized bone, autologous bone, or coralline substances. In another embodiment, the hollow body may be at least partially filled with an X-ray-opaque filler. The X-ray-opaque filler being made of a resorbable, preferably porous polymer. In order to design the filler to be X-ray-opaque, contrast medium may be added to the polymer. For PLA a marker, for example, such as zirconium dioxide, may be added, and barium sulfate may be admixed with PEEK. In another preferred embodiment, the perforations of the partitions, lateral sections or both may be filled with the X-ray-opaque filler thereby preventing the filler from falling out.
  • [0008]
    In another embodiment, a portion of the surface of the implant has thin coating having substantially no effect on the X-ray-transparency. The coating may be made of a metal, the comprising at least one of the group consisting of titanium, gold, and platinum. The coating may also be made from hydroxyapatite or tricalcium phosphate.
  • [0009]
    In another embodiment, an inter-vertebral bone implant having a total volume V comprises a front section, a back section, two lateral sections defining a central axis, and a substantially hollow interior chamber, each section having a superior and inferior vertebral contacting surface. The hollow chamber may be subdivided by at least two partitions, the at least two partitions running essentially parallel to the central axis and connecting the front section to the back section, the at least two partitions trussed together by a cross strut. The hollow chamber may have a volume, v, and wherein the ratio of V:v between the total volume V of the implant and the volume v of the hollow chamber is about 2.1. The two lateral sections have at least one perforation, the perforation having a minimum area of about 3.5 mm2.
  • [0010]
    In another embodiment, the radiation-permeable material is strengthened with fibers.
  • [0011]
    In a further embodiment, at least a portion of the surface of the implant has a substantially X-ray-transparent coating.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0012]
    Preferred features of the present invention are disclosed in the accompanying drawings, wherein similar reference characters denote similar elements throughout the several views, and wherein:
  • [0013]
    FIG. 1 is a perspective view of an illustrative embodiment of an inter-vertebral implant according to one aspect of the present invention;
  • [0014]
    FIG. 2 is a top view of the inter-vertebral implant of FIG. 1;
  • [0015]
    FIG. 3 is a front view of the inter-vertebral implant of FIG. 1; and
  • [0016]
    FIG. 4 is a side view of the inter-vertebral implant of FIG. 1.
  • DETAILED DESCRIPTION
  • [0017]
    Referring to FIGS. 1 through 4, there is shown an inter-vertebral implant configured for insertion between the adjacent vertebral endplates and permitting growth of an osseous structure through the implant. The inter-vertebral implant may be a generally annular or circular shaped hollow body 1 comprising a mantle or sleeve 6 defining a hollow cylindrical or cone section which has a front section 9, a rear section 10, and two lateral sections 11, and further defines a cylindrical or central axis 7. The hollow body 1 may be divided into chambers by at least two intermediate walls 3 running essentially or substantially parallel to cylindrical axis 7. The intermediate walls or partitions 3 connect front section 9 with back or rear section 10 of the sleeve 6, and may be supported, interconnected and spaced with respect to one another by at least one cross brace or strut 4. Intermediate walls 3 increase the support areas on the neighboring vertebral body endplates, thereby reducing the surface pressure and preventing the implant from sinking into the neighboring vertebral bodies. In addition, the chambers of hollow body 1 allow growth of an osseous structure through the implant. Moreover, each of intermediate walls 3 may be provided with at least one perforation 5 which may have an area of ranging from about 3.5 mm2 to about 10 mm2, preferably a minimum of about 3.5 mm2. The perforations 5 in the intermediate walls 3 serve to spatially fix the newly grown osseous structure and also act as an optional area for primarily introducing a filling compound, which will be explained in greater detail below.
  • [0018]
    Lateral sections 11 of sleeve 6 may also have perforations 8, which have an area ranging from about 3.5 mm2 to about 10 mm2, preferably a minimum area of about 3.5 mm2. The perforations in the lateral sections of the sleeve serve to spatially fix the newly grown osseous structure and also to provide primary support for the implant during its insertion. The perforations 8, may be similarly filled with a filling compound, to be explained in greater detail below.
  • [0019]
    A portion of the bone implant surface 2 may have a surface roughness. The surface roughness of surface 2 preferably ranges from 2 μm to about 10 μm, with a preferred minimum of 2 μm so as to provide newly grown bone tissue a better fixation to the implant, or better bone integration. An excessive surface roughness may impair the arthrodesis.
  • [0020]
    The inter-vertebral implant may be made from radiation-transparent material, preferably (PEEK), or alternatively, in another preferred embodiment, the radiation-transparent material may be made of: polyarylether ketone (PAEK), polyetherimide (PEI), polyoxymethylene (POM), liquid-crystal polymer (LCP), polymethyl pentene (PMP), polysulfone (PSU), polyether sulfone (PESU or PES), polyethylene terephthalate (PETP), polymethyl methacrylate (PMMA), or ultra-high molecular weight polyethylene (UHMW-PE). All of these preferred materials are elastic, but have various mechanical properties such as elasticity (stiffness) in addition to strength. Compared to other polymers, these preferred materials sometimes have favorable creep properties or exhibit low water absorption, therefore the material selected may depend upon the application requirements.
  • [0021]
    The radiation-transparent material of the bone implant may be fiber-reinforced, preferably with carbon or PEEK fibers. Fiber reinforcement of the radiation-transparent material enhances the mechanical properties of stiffness in general, or may provide a desired level of stiffness to the material.
  • [0022]
    Preferably, the surface 2 of the bone implant has a surface roughness of 6 μm and is at least partially provided with a thin, X-ray transparent coating, the coating preferably being metal and made of gold. Alternatively, the coating may have no effect on or may be so thin so as to have a negligible effect on radiation or X-ray transparency of the implant. Other thin metallic coatings are contemplated, for example titanium, platinum, or other appropriate implant metals are suitable. In another preferred refinement, the coating is made of a ceramic material, preferably hydroxyapatite or tricalcium phosphate. Both ceramics, hydroxyapatite and tricalcium phosphate, which are suited for a coating have the advantage that they become fully integrated into the bone, or are even replaced by new, natural bone tissue. Where the implant is made of pure PEEK, which is characterized by excellent biocompatibility, an additional coating made of a suitable material, such as the preferred metal material as described above, enhances the mechanical properties and increases the interfaces between the newly grown bone and the implant.
  • [0023]
    The ratio V:v between total volume V of the bone implant (including volume of hollow body) and volume v of the hollow body 1 is in the range of 1.9 to 2.3, preferably 2.1. It has been shown that this preferred ratio range combines the advantages of a mechanically stable implant with a maximum volume of newly grown osseous structure.
  • [0024]
    The hollow body 1 may be at least partially filled with a filler made of calcium phosphate, preferably hydroxyapatite or tricalcium phosphate, so as to provide better, more trouble-free monitoring of the arthrodesis. The hollow body may also be filled with a filler made of calcium sulfate, demineralized bone, autologous bone, or coralline substances.
  • [0025]
    Preferably, the hollow body 1 is filled at least partially with an X-ray-opaque filler made of a resorbable, preferably porous polymer. In order to design the filler to be X-ray-opaque, contrast medium may be added to the polymer. Where the filler polymer is PLA, a marker, for example, such as zirconium dioxide, may be added, and barium sulfate may be admixed with PEEK.
  • [0026]
    As explained above, the perforations 5, 8 in the implant may be at least partially filled with X-ray-opaque filler, preferably the resorbable porous polymer as previously described. Placing the filler at least partially within the perforations 5, 8 should thus prevent the filler from falling out.
  • [0027]
    According to the method of manufacturing the bone implant as described above, the annular hollow body 1 may be manufactured by injection molding, hot forming, or hot pressing. The polymer may preferably be compressed by hot forming, which is characterized particularly by better fatigue strength.
  • [0028]
    One aspect of the current invention is to provide a bone implant, in particular an inter-vertebral implant, having an optimal surface structure for the growth of bone tissue. While preferred embodiments and features of the present invention have been disclosed herein, it will be appreciated that numerous modifications and embodiments may be devised by those skilled in the art. It is intended that the appended claims cover all such modifications and embodiments as fall within the true spirit and scope of such claims and that the claims not be limited to or by such preferred embodiments or features.
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Legal Events
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May 6, 2013ASAssignment
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