|Publication number||US20060283945 A1|
|Application number||US 11/508,707|
|Publication date||Dec 21, 2006|
|Filing date||Aug 23, 2006|
|Priority date||Mar 24, 2005|
|Also published as||US7275682, US20060213964, WO2006104636A1|
|Publication number||11508707, 508707, US 2006/0283945 A1, US 2006/283945 A1, US 20060283945 A1, US 20060283945A1, US 2006283945 A1, US 2006283945A1, US-A1-20060283945, US-A1-2006283945, US2006/0283945A1, US2006/283945A1, US20060283945 A1, US20060283945A1, US2006283945 A1, US2006283945A1|
|Inventors||Jean-Louis Excoffier, Marvin Smith|
|Original Assignee||Varian, Inc.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (4), Referenced by (13), Classifications (16), Legal Events (1)|
|External Links: USPTO, USPTO Assignment, Espacenet|
This is a continuation-in-part of Application Ser. No. 11/088,539, filed Mar. 24, 2005.
The present invention relates generally to sample identification techniques, such as may be desired in conjunction with the handling of one or more individual samples as part of analytical processes. More particularly, the present invention relates to the use of radio-frequency (RF) energy to uniquely identify individual samples and/or containers in which the samples reside.
In many processes for analyzing samples, particularly in batch and serial processes where several samples are involved, it is desirable to improve throughput by providing a greater degree of automated control over various stages of the sample handling, preparation, and analysis processes and by providing better management of sample-related data. In one aspect, instrumentation for the handling, preparation and analysis of samples has become more automated. For instance, automated sample handling systems have been developed that include one or more trays holding arrays of vials, test tubes, or multi-well plates containing small quantities of liquid samples. These systems typically include a sampling needle that can be programmed to move to each vial in order to dispense samples into the vials or aspirate samples from the vials. Alternatively, the vials or trays holding the vials may be moved to a sampling needle or other component of the sample handling system. In another aspect, steps have been taken to improve the identification of individual samples. Improvements in sample identification have primarily been made through the utilization of barcode scanning systems. Barcode scanning systems employ an optical barcode scanner that reads a barcode printed on a label. The barcode consists of a combination of dark parallel bars and light spaces between the bars. The barcode scanner reads the barcode by directing a beam of light at the barcode. Because the dark bars of the barcode absorb light and the light spaces reflect light, a detector in the barcode scanner can receive the reflected light signals and convert them into electrical signals, which thereafter can be recognized by electronic means as characters. Barcode labels have been applied to vials and, in the case of multi-well plates, a single barcode label has been applied to a plate.
While barcode systems and other optical techniques may be useful in such applications as the tracking of consumer goods, these types of systems present problems when applied to procedures for handling small liquid-phase samples in conjunction with analytical techniques. The information represented by a barcode is quite limited and fixed. The barcode typically constitutes a short series of characters such as those corresponding to the well-known Uniform Product Code (UPC). Due to the brevity of these character sets, the barcode is capable of identifying only the type of sample or the tray or group of samples of which the sample is a part. When a large number of individual samples are to be handled and analyzed, each of which may be different from the others in terms of composition or other parameters, there are not enough characters in a barcode to adequately distinguish one given sample as being unique from another sample. Even if a barcode were to be employed to uniquely identify a sample as being, for example, Sample #1, that same barcode cannot be used to provide any additional information about that particular sample.
Moreover, because a barcode system depends on optics, it is orientation-sensitive; that is, there is only a finite range of angles between a barcode and a barcode scanner over which optical communication will be successful. When applied to sample handling and analysis systems, the barcode system often requires that several barcode scanners be located at various points along the system in order to adequately track the sample, or that a given barcode-containing vial be transported to a single barcode scanner. Additionally, again due to the use of optics, a barcode-containing vial must be precisely positioned in relation to a barcode scanner to ensure that no other object will interfere with the light path, including neighboring vials. Another related problem stems from the fact that an optical path is easily modified by the presence of substances commonly encountered in sample handling. The smearing of the printed barcode through contact with a researcher or an object, the marring or degradation of the barcode by solvents or other substances, or simply the obstructive presence of fluids or particles on the barcode, all may destroy the ability of the barcode to be accurately read by a barcode scanner.
In view of the foregoing, it would be advantageous to provide a means for uniquely identifying vials and other types of sample containers without the problems attending barcode technology and other known techniques employed in conjunction with sample preparation, handling, and/or analysis. The ability to read an identification code as the vial is accessed for sampling or mixing operations, without moving the vial to another position, would also present significant advantages, in terms of time and chain of custody-type concerns.
To address the foregoing problems, in whole or in part, and/or other problems that may have been observed by persons skilled in the art, the present disclosure provides apparatus, devices, and methods for uniquely identifying individual analytical samples, as described by way of example in implementations set forth below.
According to one implementation, a radio frequency identification (RFID) reader is provided. The reader comprises a body including a proximal end region, an RF transceiver antenna mounted to the body at the proximal end region, and an RF shield mounted to the body and extending out from the body beyond the proximal end region to an open end of the RF shield. The RF shield defines an interior space between the body and the open end, wherein the antenna is surrounded by the RF shield.
According to another implementation, at least a portion of the RF shield is movable relative to the body.
According to another implementation, a sample holder is provided. The sample holder comprises an RF shield. The RF shield includes a plurality of walls defining a plurality of interior spaces. A sample container is positioned in at least one of the interior spaces. The sample container includes an RFID tag surrounded by one or more of the walls.
According to another implementation, an RFID apparatus is provided. The apparatus includes an RFID reader including an RF transceiver antenna, a sample container including an RFID tag, and an RF shield defining an interior space between the reader and the container. The antenna and the RFID tag are surrounded by the RF shield. In one example of an embodiment of the RFID apparatus, the RF shield is mounted to the reader. In another example, the sample container is positioned in the interior space.
According to another implementation, a method for identifying an object is provided. According to the method, a reader that includes a radio frequency (RF) transceiver antenna is moved into proximity with a sample container whereby the antenna can communicate with a radio frequency identification (RFID) tag of the sample container. The antenna and the RFID tag are surrounded with an RF shield such that the antenna and RFID tag are isolated from an environment external to the RF shield.
According to another implementation of the method, the antenna is employed to read a code stored by the RFID tag whereby the sample container or a sample contained in the sample container can be identified.
According to another implementation, the method further comprises, after reading the code, associating the code with information relating to the identified sample.
According to another implementation of the method, the RF shield is attached to the reader and defines an interior space in which the antenna is located. The reader is moved toward the sample container such that the RFID tag becomes located within the interior space.
According to another implementation of the method, the RFID tag is located in an interior space defined by the RF shield. The reader is moved toward the sample container such that the antenna becomes located within the interior space.
According to another implementation, a sample container includes a container structure extending along a central axis. The container structure encloses an interior and includes an open end. A first cap is mounted to the container structure at the open end and has a first aperture located at the central axis. A second cap is mounted to the first cap and has a second aperture aligned with the first aperture along the central axis. An RFID tag is mounted at the second cap in off-center relation to the central axis. In some implementations, the sample container may further include a closure member mounted at the open end, whereby the interior is isolated from an environment external to the container structure and the first and second apertures provide access to the closure member.
In general, the term “communicate” (for example, a first component “communicates with” or “is in communication with” a second component) is used herein to indicate a structural, functional, mechanical, electrical, optical, magnetic, ionic or fluidic relationship between two or more components or elements. As such, the fact that one component is said to communicate with a second component is not intended to exclude the possibility that additional components may be present between, and/or operatively associated or engaged with, the first and second components.
The subject matter disclosed herein generally relates to the handling of one or more individual samples as, for instance, may be performed as part of or in preparation for a sample analysis process. The subject matter provides for the unique identification of individual samples so that one sample may be readily distinguished from another sample and that once identified, the identity of the sample may be correlated with additional information uniquely pertaining to that sample. Accordingly, systems, apparatus, and methods disclosed herein may be particularly beneficial in applications entailing the analysis of several individual samples simultaneously or serially in a given test run, where one or more samples may be different from other samples, and where one or more components of the system or apparatus may be partially or fully automated. The approach toward identification of samples disclosed herein makes use of RF energy and therefore does not rely on optical energy and is not limited by optics-related problems. Examples of implementations of apparatus, systems, devices, and/or related methods for sample identification and sample handling are described in more detail below with reference to
Sample container 110 may be any container suitable for containing an analytical sample, particularly a liquid-phase or multi-phase sample for which one or more quantitative and/or qualitative analyses are desired. Examples of sample containers 110 include, but are not limited to, vials, test tubes, cuvettes, wells, flow-through cells, and the like. In the example illustrated in
Generally, no limitation is placed on the size of container structure 112 or its capacity for holding a volume of sample material. In some implementations, container structure 112 may enclose an interior that has a volume ranging from approximately 0.1 mL to approximately 1000 mL. In other implementations, the volume may range from approximately 0.1 mL to approximately 100 mL. In other implementations, the volume may range from approximately 1 mL to approximately 50 mL. In other implementations, the volume may range from approximately 2 mL to approximately 20 mL.
Container structure 112 may also include a closure member 124, for example a septum or plug, that is attached or mounted to container structure 112 so as to close off its open end 118 and thereby isolate or seal the interior of sample container 110 from the ambient environment. As appreciated by persons skilled in the art, closure member 124 may be composed of a resilient or deformable material that enables closure member 124 to perform its isolating function, as well as to be pierced by a needle without impairing its ability to provide isolation. In some implementations, closure member 124 is secured to container structure 112 by press-fitting, which may be facilitated by the installation of cap 120 onto container structure 112. The aperture 122 of cap 120 provides external access to closure member 124 so that a needle or the like may be inserted through closure member 124 and into container structure 112. In some implementations in which closure member 124 is not needed, sample container 110 is employed in an open mode, in which case the aperture 122 of cap 120 provides direct access to the interior of sample container 110.
In some implementations, container structure 112 may have open ends at both the top and the bottom, and closure members and/or caps at both the top and the bottom. Examples of these container structures include purge and trap vials commercially available from Varian, Inc., Palo Alto, Calif., and typically are employed for soil analysis or other types of environmental analysis. In some implementations, sample container 110 may include a magnetic stirring or agitating element such as a bar or bead.
For purposes of the present disclosure, no limitation is placed on the composition of the sample or its properties (for example, molecular weight, polarity or non-polarity, ionic, volatility, temperature, or the like), or on the manner in which the sample is provided to sample container 110. In a typical implementation, the sample provided to sample container 110 is predominantly a liquid but in other implementations may be a multi-phase mixture. For example, the sample may be a solution, emulsion, suspension or mixture in which analyte components (for example, molecules of interest) are initially dissolved in one or more solvents or carried by other types of components. In some implementations, particularly those associated with headspace sampling techniques and which in turn may be associated with gas chromatography (GC) or solid-phase micro-extraction (SPME), sample container 110 may contain a vapor above a liquid or solid. In such techniques, it is the vapor that typically is sampled, and hence the vapor may be considered to be the sample or part of the sample. Accordingly, terms such as “sample” or “sample material” as used herein are not limited by any particular phase, form, or composition. Generally, however, the sample contains analytes of the type that are amenable to qualitative and/or quantitative instrumental techniques of analytical chemistry such as, for example, the various types of chromatography, dissolution, mass spectrometry, spectroscopy, nuclear magnetic resonance (NMR) spectrometry or imaging, calorimetry, and the like. The sample may be dispensed into sample container 110 or removed from sample container 110 either manually or by automated means.
In accordance with implementations described in this disclosure, sample container 110 includes a second structure that supports a device for storing information uniquely pertaining to the sample contained within sample container 110. This device, which may be referred to as a radio-frequency identification (RFID) tag 126, transponder, smart label, or smart chip, is described in more detail below. In the example illustrated in
Sample handling apparatus 100 may be any apparatus that can function to transfer a sample to and/or from sample container 110, and/or transfer a probe of any suitable type into and/or out from sample container 110 such as, for example, a sample-absorbing wick or fiber, an optical probe, a temperature probe, a stirrer or agitator, or the like. In the present context, the term “transfer” is intended to encompass dispensing or loading a sample (or a portion of a sample) into sample container 110, aspirating or removing a sample (or a portion of a sample) from sample container 110, or both, or inserting a probe into sample container 110 or removing a probe from sample container 110. For any of these purposes, sample handling apparatus 100 includes a sample transfer or probe device 130 that is movable toward and away from sample container 110, and hence toward and away from RFID tag 126. Accordingly, the term “sample probe device” may encompass a sample transfer device or a probe transfer device. The mobility of sample probe device 130 may be fully automated or semi-automated. Moreover, one or more components of sample probe device 130 may be movable in one, two, or three dimensions. The portion of sample probe device 130 illustrated in
Sample probe device 130 may also include a sample probe 134 that may be adapted to carry out one or more functions or operations. In the example illustrated in
In some implementations, sample probe 134 may be a hollow sheath that contains a sample-absorbing fiber. This fiber may be extended into a liquid sample contained in sample container 110 (for example, in SPME techniques) or into a vapor contained in sample container 110 above the liquid or solid (for example, in headspace SPME techniques). The fiber absorbs compounds of interest from the liquid or vapor and is then retracted into the sheath. The sheath is then drawn out from sample container 110. The sheath may function as a needle so that it is able to pierce a closure member 124 while protecting the fiber. In other implementations, sample probe 134 may be adapted to perform some type of analysis, detection, or measurement. Accordingly, sample probe 134 may be, for example, an optical probe or a temperature-sensing probe. Alternatively, sample probe 134 may also include the afore-mentioned sheath that is adapted for piercing a closure member 124 while protecting this type of probe.
Sample probe device 130 further includes a radio-frequency (RF) transceiver antenna 150 for communicating with RFID tag 126 of sample container 110. In some implementations, RF transceiver antenna 150 advantageously is positioned at or near a lowermost part of lower end region 136 of sample probe device 130 for communicating with RFID tag 126 at close range, and in some implementations may even contact RFID tag 126 although contact is not required. This configuration ensures that RF transceiver antenna 150 will come into close proximity with RFID tag 126 (for example, a few millimeters) when sample probe device 130 is moved into position over sample container 110. As appreciated by persons skilled in the art, the sensitivity of RF transceiver antenna 150 and/or the electronics with which it communicates can be adjusted for close-range communication with RFID tag 126. In the present context, this configuration ensures that RF transceiver antenna 150 is able to discriminate the RFID tag 126 of one sample container 110 from the RFID tag 126 of another, nearby sample container 110. That is, when sample probe device 130 is positioned over sample container 110, RF transceiver antenna 150 should be able to read the RFID tag 126 of that particular sample container 110 and not an RFID tag 126 provided with any other sample container 110. Moreover, RF transceiver antenna 150 may be utilized to sense whether a particular sample container 110 is missing from an array of sample containers or contains no RFID tag 126. For any of these purposes, as shown in the example illustrated in
In some implementations, also shown in the cross-sectional view of
Generally, RFID tag 126 may be any device capable of storing data and transmitting the data via an RF carrier signal in response to a query from a suitable reader, such as an RF-based query transmitted by an RF transceiver antenna 150. For example, RFID tag 126 may be realized by forming an integrated circuit on a suitable substrate such as a silicon chip. The chip in turn may be provided on a flexible substrate such as a label or adhesive sticker. In some implementations, RFID tag 126 may also include a small, typically flexible antenna interconnected to the integrated circuit or chip to enable RFID tag 126 to transmit RF signals to a suitable reader such as RF transceiver antenna 150. In other implementations, electrical contacts or interconnects provided with RFID tag 126 may serve the same purpose as an antenna in which case a discrete antenna need not be fabricated with RFID tag 126.
RFID tag 126 may be passive, active, or semi-passive. As can be appreciated by persons skilled in the art, a passive RFID tag 126 does not require a power source for its operation. A passive RFID tag 126 can absorb some of the electromagnetic energy from a signal sent by RF transceiver antenna 150 and reflect the energy as an RF return signal that carries the coded information stored in its memory. For example, an RF scan transmitted by RF transceiver antenna 150 may induce electrical current in the antenna or contact of RFID tag 126, thereby providing enough power for RFID tag 126 to respond properly. On the other hand, active RFID tags and battery-assisted passive RFID tags (or semi-passive RFID tags) require a battery or other suitable power source. In battery-assisted passive RFID tags, a battery is employed to provide power for operation of the chip but not for communicating with RF transceiver antenna 150. The powered (active and semi-passive) RFID tags typically have longer operating ranges and greater capacity for data storage than passive RFID tags, but cost more and may have much shorter operating lives. The physical dimensions of a passive or active RFID tag may be in the micron or millimeter range. Typically, a passive RFID tag will be smaller than an active RFID tag.
RFID tag 126 and RF transceiver antenna 150 may operate within any suitable range of radio frequencies, including low-frequency or LF (typically considered as including the range of approximately 125-134 kHz), high-frequency or HF (typically 13.56 MHz or thereabouts), ultra-high frequency or UHF (typically considered as including the range of approximately 868-956 MHz) and microwave (for example, 2450 MHz). Each frequency or range of frequencies may have advantages or disadvantages depending on the particular implementation, as well as factors such as intended read range, operating environment, power requirements, costs of materials and fabrication, geometry, and the like. For purposes of the implementations disclosed herein, the frequency utilized for operation is one that is compatible with close-range, error-free communication, i.e., typically in the range of a few millimeters as previously noted.
The chip provided with RFID tag 126 may have read-write or read-only capability. When equipped with a read-write chip, new information can be added to RFID tag 126 or written over existing information. When equipped with a read-only chip, the information stored by RFID tag 126 cannot be changed unless the chip is reprogrammed. As appreciated by persons skilled in the art, the read-only chip of RFID tag 126 may include electrically erasable programmable read-only memory (EEPROM).
The data recorded by and stored on RFID tag 126 includes enough information to uniquely identify the sample residing in sample container 110 so that sample container 110 and/or its sample can be discriminated from other sample containers 110 and/or their respective samples. Generally, the code is long enough to enable each RFID tag 126 employed in a given system or procedure to have a unique identity for purposes of tracking through the system, correlation with other data, and the like. As a few examples, the size of the code may be 64 bits or 96 bits, although in other implementations the code may be larger or smaller. In the case where the code is employed simply as a unique identifier for a sample contained in a sample container 110, the code may be associated with an address in a remote memory where more detailed information regarding the sample has been stored, such as in a database stored on a computer provided with or communicating with sample handling system 100. For example, once the code has been read by RF transceiver antenna 150, the code may then used to search the database for more detailed information specifically relating to the individual sample identified by the code. The types of information with which the code may be associated may depend on many factors, such as the type of analysis or analyses to be performed on samples or the types of analytical instrumentation to be employed. The types of information may include, but are not limited to, the composition and properties of the sample (to the extent known), the origin of the sample (for example, a particular test site, specimen, patient, or the like), the date and time the sample was taken or prepared, the conditions under which the sample was prepared, the types of reagents, solvents, additives or chemical labels combined with the sample, the position (for example, row/column) of the sample container 110 within an array of sample containers 110, the identity of the particular group of sample containers 110 with which the sample container 110 is arranged (for example, a vial rack or tray, multi-well plate, or the like), and the like. Depending on the storage capability of RFID tag 126, one or more of these types of data may be directly stored in RFID tag 126 along with its identification code.
Sample handling apparatus 400 may additionally include a mobile sampling assembly such as a robotic assembly 430. Robotic assembly 430 supports a movable member 132 such as a sample probe mounting device or carriage device, which may be configured as a sample probe device 130 and include a sample probe 134 as described above in conjunction with
Sample probe device 130 is movably connected to another movable member 432 so as to be movable within a guide means such as a track 434 of movable member 432 along the Z-axis. In alternative implementations, sample probe 134 may itself be movable relative to a mounting structure of robotic assembly 430. Movable member 432 in turn is movably connected to a guide means such as an arm 436 or similar structure such that movable member 432 is movable along the X-axis. Arm 436 in turn is movably connected to another guide means such as an arm 438 such that arm 436 is movable along the Y-axis. Motors or actuators (not shown) responsible for the movement of these components in the various directions may be programmed so that sample probe 134 is positionable over designated sample containers 110 according to any desired sequence.
Sample probe 134 may communicate with other fluid circuitry typically provided with sample handling system 400. In
Sample handling system 400 may further include electronic circuitry 470 for controlling the various operations of sample handling system 400. Electronic circuitry 470 may include hardware control circuitry 472 that is conventionally associated with sample preparation and liquid handling instrumentation. For example, hardware control circuitry 472 may control the operations of the various components of robotic assembly 430 and fluid circuitry 450. As another example, hardware control circuitry 472 may control the sequential injections of samples into analytical instrument 460 or combination of analytical instruments such as, for example, those associated with chromatography, spectroscopy, mass spectrometry, nuclear magnetic resonance spectrometry, calorimetry, and the like. Accordingly, hardware control circuitry 472 is schematically illustrated as electrically communicating with robotic assembly 430, fluid circuitry 450, and analytical instrument 460 via lines 474, 476, and 478, respectively. Electronic circuitry 470 may be programmable for all such purposes, such as through the execution of software and/or in response to user input via a suitable peripheral device.
In the example illustrated in
It will be understood that hardware control circuitry 472, RF signal processing circuit 480, and sample information-containing memory 484 are illustrated in
Referring now to
At block 510 in
At block 520 in
In some implementations, the method just described and illustrated in
In some implementations, RF transceiver antenna 150 may be utilized to determine whether a particular position within or relative to a sample handling apparatus or system 100 or 400 is occupied by a sample container 110, or whether a sample container 110 is missing from that particular position, or whether a sample container 110 occupying that particular position lacks an RFID tag 126 or has a defective RFID tag 126. The RF-related components as disclosed herein allow such operations even in the presence of other RFID-tagged sample containers occupying neighboring positions in close proximity to the presently targeted position. In still other implementations, RF transceiver antenna 150 may be utilized to scan an entire array of sample containers 110 (see, for instance, sample holding assembly 410 and associated components illustrated in
In some implementations, sample probe 132 may perform an analytical function or operation while located at a given sample container 110, and this function or operation may be executed before or after RF transceiver antenna 150 reads the data from RFID tag 126, or while the data is being read. Examples of analytical functions or operations that may be performed by sample probe 132 may include analytical, detecting, or measuring tasks such as, optical detection, temperature measurement, or the like.
As further illustrated in
Also illustrated in
The provision of the RF shield 632 may be desirable in implementations where the respective RFID tags associated with separately identifiable items or objects are in very close proximity to each other, the respective positions of the RFID tags relative to their corresponding items are inconsistent from one item to the next item, and/or the position of the RFID tag of one or more items is not accurately known. In such situations, the possibility exists that the RF transceiver antenna 620 will pick up a signal from items other than the item of interest.
Of particular interest in this example is the relatively close proximity of the respective RFID tags 670 and 674 of the center and rightmost sample holding units 658 and 662 to each other. In such a situation, it is possible for the reader 604 to pick up a signal from the RFID tag 674 of the rightmost sample holding unit 662, or for a signal from the RFID tag 674 of the rightmost sample holding unit 662 to otherwise interfere with the desired communication between the reader 604 and the RFID tag 670 of the central sample holding unit 658. Due to the close proximity of the RFID tags 670 and 674, it is likely that the RFID tag 674 will provide a signal of similar magnitude to the signal provided by the RFID tag 670 such that the RF processing circuitry 630 associated with the reader 604 may have difficulty discriminating between the two signals and selectively reading the target RFID tag 670.
Several problems may arise from erroneous communication between the reader 604 and a neighboring RFID tag (e.g., the RFID tag 674 of the rightmost sample holding unit 662) instead of or in addition to intended communication between the reader 604 and a target RFID tag (e.g., the RFID tag 670 of the central sample holding unit 658). As a few examples, the reader 604 may acquire information from the wrong sample holding unit, the reader 604 may erroneously identify a neighboring sample holding unit as being the target sample holding unit of interest, the reader 604 may determine an incorrect position of the target sample holding unit, the reader 604 may erroneously determine that the target sample holding unit is present or absent when in fact it is a neighboring sample holding unit that is present or absent, etc.
As demonstrated in
In the example specifically given in
As illustrated in
In practice, individual sample holding units 654, 658 and 662 such as sample containers are placed in respective wells 734 of the RF shielding structure 732. Alternatively, a sample holder 750 containing individual sample holding units 654, 658 and 662 is interfaced with the RF shielding structure 732 such that each sample holding unit 654, 658 and 662 is positioned within a corresponding well 734. In either case, the RFID tag 666, 670 and 674 of each respective sample holding unit 654, 658 and 662 is positioned in the interior space 736 of a corresponding well 734. A target sample holding unit—the central sample holding unit 658 in the present example—is selected, and the reader 704 is moved to the target sample holding unit 658. The reader 704 is lowered toward the target sample holding unit 658. The reader 704 is lowered far enough not only to establish a good communication link 678 between the RF transceiver antenna 620 and the RFID tag 670 of the target sample holding unit 658, but also to position the RF transceiver antenna 620 within the well 734 of the target sample holding unit 658 and thus effectively isolate the RF transceiver antenna 620 from the RFID tags of any neighboring sample holding units.
In other implementations, features or elements of the RF shielding components illustrated in
In some implementations, when moving an RFID tag reader into proper position over a target sample holding unit, it is possible for the open end of the RF shield provided with the reader to come into contact with a surface, such as a base supporting sample holding units, a portion of the target sample holding unit itself, or the bottom of the gap or groove surrounding the target sample holding unit. Such contact may cause misalignment of or damage to components and/or reduce the effectiveness of the isolation provided by the RF shield.
To prevent the RF shield 832 or its associated reader 804 from becoming misaligned or damaged from impacting an obstruction, and to ensure the effectiveness of RF isolation in such case, the RF shield 832 may be connected to the main body 808 of the reader 804 so as to be movable (e.g., retractable) relative to the reader 804, as depicted by the arrow 882 in
Referring now to
In one non-limiting example, one or more sides 926 of the substrate 916 have a length ranging from about 0.5 to about 10 mm, the width of the elongate structure forming the antenna 918 ranges from about 5 to about 50 μm, and the gap 930 between each adjacent section of the antenna 918 ranges from about 2 to about 8 μm. In one particular example, the length of each side 926 of the substrate 916 is about 2.5 mm, the width of the elongate structure forming the antenna 918 is about 14 μm, and the gap 930 between each adjacent section of the antenna 918 is about 4 μm. In one implementation, the RFID tag 900 may be provided as a Coil-on-Chip™ device commercially available from Maxell Corporation of America, Fair Lawn, N.J.
In the ideal arrangement 1100 illustrated in
From the foregoing, it may be seen that implementations disclosed herein can provide advantages over barcode technology and other previous techniques for identifying samples. For example, the RF transceiver antenna of a reader does not require a line of sight with an RFID tag in order to detect the information stored by the RFID tag, whereas barcode scanners need to “see” a barcode in order to read it. Moreover, RFID tags are insensitive to orientation with a reader, whereas a barcode must be optically aligned with a barcode scanner. RFID tags allow for individual sample containers to have unique identifiers and can quickly identify several individual samples either simultaneously or sequentially, whereas the typical barcode provides only an identification of a manufacturer and product. In closely arranged groupings of sample containers, an RF transceiver antenna and a selected RFID tag can communicate without interference or error due to the proximity of other tagged sample containers. RFID tags are much more robust than barcode labels, and have much longer useful lives. RFID tags are much more resistant to potential laboratory mishaps such as smearing, solvent exposure, abrasion, obstruction, and the like. RFID tags are programmable and may further be reprogrammable. The same RFID tag can be recoded with new information when desired. An RFID tag in many implementations can store much more information than is possible with a barcode label. The RFID tags in combination with RF-based readers may be easily integrated into existing sample handling systems without unduly affecting any other pre-existing, more conventional operations of such systems. Because an RF interrogation element such as an antenna can be easily incorporated into a moving component such as a device or assembly supporting a sample conduit, the implementations disclosed herein introduce the concept of moving the RF interrogation element to sample containers. Individual sample containers do not need to be moved to reading or scanning stations or the like.
Moreover, it may be seen that implementations disclosed herein may eliminate or significantly reduce the occurrence of cross-reading among closely spaced RFID tags of separately identifiable objects such as sample containers, particularly when the positions of RFID tags relative to their objects are not well-controlled.
It will be understood that various aspects or details of the invention may be changed without departing from the scope of the invention. Furthermore, the foregoing description is for the purpose of illustration only, and not for the purpose of limitation-the invention being defined by the claims.
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|U.S. Classification||235/439, 235/487, 235/451|
|International Classification||G06K19/00, G06K7/00, G06K7/08|
|Cooperative Classification||G01N2035/00782, G01N35/1079, G01N35/00732, B01L2300/022, B01L2300/042, B01L3/5457, B01L2300/024|
|European Classification||B01L3/5457, G01N35/10P, G01N35/00G3C|
|Aug 23, 2006||AS||Assignment|
Owner name: VARIAN, INC., CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:EXCOFFIER, JEAN-LOUIS;SMITH, MARVIN H.;REEL/FRAME:018208/0903;SIGNING DATES FROM 20060728 TO 20060814