|Publication number||US20070227932 A1|
|Application number||US 10/582,583|
|Publication date||Oct 4, 2007|
|Filing date||Dec 9, 2004|
|Priority date||Dec 10, 2003|
|Also published as||EP1697228A1, WO2005056419A1|
|Publication number||10582583, 582583, PCT/2004/50036, PCT/GB/2004/050036, PCT/GB/2004/50036, PCT/GB/4/050036, PCT/GB/4/50036, PCT/GB2004/050036, PCT/GB2004/50036, PCT/GB2004050036, PCT/GB200450036, PCT/GB4/050036, PCT/GB4/50036, PCT/GB4050036, PCT/GB450036, US 2007/0227932 A1, US 2007/227932 A1, US 20070227932 A1, US 20070227932A1, US 2007227932 A1, US 2007227932A1, US-A1-20070227932, US-A1-2007227932, US2007/0227932A1, US2007/227932A1, US20070227932 A1, US20070227932A1, US2007227932 A1, US2007227932A1|
|Inventors||Jonathan Bobbett, Jonathan Neal|
|Original Assignee||3Point Blue Limited|
|Export Citation||BiBTeX, EndNote, RefMan|
|Referenced by (6), Classifications (8), Legal Events (1)|
|External Links: USPTO, USPTO Assignment, Espacenet|
The present invention relates to improvements in or relating to blister packs. In particular, it relates to an improvement in blister packs which makes it more difficult for a child to release a medicament from the blister pack without making it unduly difficult for the elderly or infirm to remove the medicament.
Conventional blister cards or packs typically include a plastics sheet material moulded to provide a plurality of recesses into each of which recesses is placed a medicament, typically in tablet or capsule form. The medicaments are held in place by means of a foil retaining sheet. When the patient wishes to use the medicament, they push the tablet or capsule through the foil retaining sheet. For ease of release, the foil retaining sheet is usually rather thin and easily ruptured. This raises issues of child safety, as it becomes very easy for a child to tamper with the blister pack, so releasing the medication. One approach to improving the child-resistance of a blister pack is to increase the thickness of the foil in order to require greater strength in order to push the medicament through the foil retaining sheet. However, one needs to be careful to avoid producing a blister pack from which elderly or infirm might find it impossible to gain access to their medicament.
Accordingly, there is a need to provide a blister pack that provides resistance to tampering by children but allows the elderly or infirm to release their medicament without undue difficulty. WO 02/32666 describes one approach in which a first sheet material is attached to the foil of a conventional blister pack by a temporary adhesive. The first sheet covers all of the individual medicament recesses, but is itself of smaller overall dimensions than the blister pack itself. Overlaying the first sheet is a second sheet material. This is provided with a permanent adhesive and is larger than the first sheet material such that where it overlies the first sheet, it is adhered thereto by the permanent adhesive, but where it does not overlie the first sheet, it adheres by the permanent adhesive to the foil retaining sheet of the blister pack. The second sheet is perforated or scored in the area around where it overlies each medicament recess. The user peels off a portion of the second sheet adjacent the location of a medicament. The perforations ensure selective removal only of that part adjacent the chosen medicament and the use of a permanent adhesive provides that a respective portion of the first sheet material is also removed. The user can then press the medicament through the foil layer as usual.
However, the arrangement of WO 02/32666 requires careful cutting and assembly of the components. The present invention seeks to provide an alternative blister pack arrangement.
In its broadest sense, in one aspect the present invention provides a medicament blister pack comprising a medicament tray having an upper surface to which is bonded a medicament retaining sheet. The medicament retaining sheet comprises a laminate comprising bonded first and second sheet materials.
Preferably, the medicament tray comprises a moulded plastics or metarised tray having a plurality of individual medicament receiving cavities. Suitably, the tray is formed by vacuum moulding.
Preferably, the first sheet material includes lines of weakness defining medicament release zones, or includes a random or structured pattern of lines of weakness having a substantially uniform distribution over the first sheet material.
Typically, the lines of weakness defining medicament release zones comprise perforations and/or slits. Suitably, the lines of weakness are formed by kiss-cutting or laser-cutting.
In a second aspect the present invention provides a medicament retaining sheet for a medicament blister pack, the retaining sheet comprising a laminate comprising bonded first and second sheet materials; said first sheet having first and second faces and said second sheet having first and second faces, wherein the first face of the second sheet and the second face of the first sheet are opposed and bonded together and wherein the first sheet includes lines of weakness defining medicament release zones.
In a third aspect, the present invention provides the use of a laminate comprising bonded first and second sheets as a medicament retaining sheet in a blister pack, wherein the first sheet includes lines of weakness defining medicament release zones.
The first sheet may be formed from any suitable material such as metal foil, metalised plastics, plastics, materials or paper. Preferably, the first sheet is a paper material. Suitably the paper material is a machine-coated or blade-coated paper.
Preferably, the first sheet has a weight of from 15 to 100 g/m2; more preferably from 20 to 50 g/m2; even more preferably about 30 g/m2.
Preferably, the first sheet has a thickness of from 15 to 120 μm; more preferably from 20 to 60 μm; even more preferably about 30 μm.
Preferably, the first sheet has first and second faces and lines of weakness may be formed partially in either the upper or lower surface or may extend from the first face through the sheet to the second face. Typically, the lines of weakness comprise perforations, slits or score lines, formed by kiss-cutting or laser-cutting.
Preferably, the second sheet material is a metal foil or a metalised plastics sheet.
Preferably, the foil sheet is from 6 to 50 μm in thickness.
Suitably, the first sheet material is bonded to the second sheet material by means of an adhesive, preferably a permanent adhesive.
Advantageously, no adhesive is provided, or the adhesive is inactivated, between the first and second sheet materials in the medicament release zones.
In a fourth aspect, the present invention provides a first sheet material adapted for application to a medicament blister pack comprising a medicament tray having an upper surface to which is bonded a second sheet material.
Suitably, the first sheet is a printable material, such as paper or a synthetic material. Suitably the paper material is a machine-coated or blade-coated paper. Preferably, the paper has a weight of 20 g/m2 or more, more preferably from 50 to 400 g/m2; even more preferably from 50 to 200 g/m2, most preferably from 50 to 150 g/m2. Advantageously, the paper has a weight of from 50 to 120 g/m2, suitably about 80 to about 85 g/m2.
The first sheet has first and second faces and lines of weakness may be formed partially in either the upper or lower surface or may extend from the first face through the sheet to the second face. Typically, the lines of weakness comprise perforations, slits or score lines, formed by kiss-cutting or laser-cutting.
The above and other aspects of the present invention will now be illustrated in further detail, by way of example only, with reference to the accompanying figures in which:
Referring to the figures, there is shown a blister pack 10 comprising a moulded plastics tray 11 including a plurality of moulded cavities or recesses 12 each containing a medicament in the form of a capsule or tablet 13. The tablets are held in place by means of a medicament retaining sheet 14. Retaining sheet 14 is adhered to tray 11 by means of an adhesive 15.
Medicament retaining sheet 14 is a laminate comprising bonded first 20 and second 21 sheet materials. Suitably, the first sheet material 20 is a paper material. Suitably, the second sheet material 21 is a sheet material of the type conventionally used in the production of blister packs. For example, the second sheet material 21 may be a thin metallic foil or a metalised plastics sheet material.
The medicament retaining sheet 14 is adhered to the tray 11 by adhesive 15 contacting second sheet material 21. The adhesive 15 may be applied to the retaining sheet 14 or directly to the tray 11, for example by roller-coating.
The medicament retaining sheet 14 may be applied to the tray 11 during the manufacturing process. Alternatively, the first sheet material may be applied as a label to a pre-formed blister pack, for example, by an end user. The label may include an adhesive surface for application to the foil of the blister pack. This forms another aspect of the present invention.
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US7992477 *||Jul 12, 2005||Aug 9, 2011||Yuyama Mfg. Co., Ltd.||Medicine feeding device|
|US8079475 *||Jan 24, 2008||Dec 20, 2011||Sonoco Development, Inc.||Blister package|
|US8479921||Dec 9, 2009||Jul 9, 2013||Amcor Flexibles, Inc.||Child resistant blister package|
|US9138378||Jul 6, 2011||Sep 22, 2015||Sonoco Development, Inc.||Blister package and method of forming same|
|US20050284789 *||Jun 29, 2004||Dec 29, 2005||Carespodi Dennis L||Laser-scored push-through blister backing and methods of making same|
|US20060104765 *||Jul 12, 2005||May 18, 2006||Shoji Yuyama||Medicine feeding device|
|International Classification||B65D83/04, B65D75/34, B65D75/32|
|Cooperative Classification||B65D75/327, B65D2575/3236, B65D2215/04|
|Mar 28, 2007||AS||Assignment|
Owner name: 3POINT BLUE LIMITED, UNITED KINGDOM
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BOBBETT, JONATHAN;NEAL, JONATHAN;REEL/FRAME:019078/0982
Effective date: 20060612