Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.

Patents

  1. Advanced Patent Search
Publication numberUS20090124916 A1
Publication typeApplication
Application numberUS 12/319,833
Publication dateMay 14, 2009
Filing dateJan 13, 2009
Priority dateAug 26, 2003
Also published asUS7479112, US20050049492
Publication number12319833, 319833, US 2009/0124916 A1, US 2009/124916 A1, US 20090124916 A1, US 20090124916A1, US 2009124916 A1, US 2009124916A1, US-A1-20090124916, US-A1-2009124916, US2009/0124916A1, US2009/124916A1, US20090124916 A1, US20090124916A1, US2009124916 A1, US2009124916A1
InventorsRobert J. Sweeney, Douglas R. Daum
Original AssigneeSweeney Robert J, Daum Douglas R
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Acoustic physiological sensor
US 20090124916 A1
Abstract
This document describes, among other things, a body having at least one acoustically detectable property that changes in response to a change in a physiological condition, such as ischemia. The body is positioned with respect to a desired tissue region. At least one acoustic transducer is used to acoustically detect a change in physical property. In one example, the body is pH sensitive and/or ion selective. A shape or dimension of the body changes in response to pH and/or ionic concentration changes resulting from a change in an ischemia state. An indication of the physiological condition is provided to a user.
Images(6)
Previous page
Next page
Claims(20)
1. An apparatus comprising:
a physiological sensor including a biocompatible body sized and shaped to be implanted within a subject to contact tissue, at least a portion of the body including a material having at least one physical property that changes in response to a physiological condition predictive or indicative of a tachyarrhythmia when that portion of the body is implanted in contact with the tissue, wherein the change in the at least one physical property occurs because of the contact between that portion and the tissue, wherein the portion of the body is sized and shaped such that the change in the physical property is detectable using acoustic energy to provide an indication of the physiological condition.
2. The apparatus of claim 1, wherein the change in the physical property of the body includes a change in size of the body.
3. The apparatus of claim 1, wherein the change in the physical property of the body includes a change in an acoustic property of the body.
4. The apparatus of claim 1, comprising an implantable transducer configured to supply the acoustic energy for providing the indication of the physiological condition.
5. The apparatus of claim 1, wherein the body includes at least a portion of a catheter.
6. The apparatus of claim 1, wherein the body includes a sphere.
7. The apparatus of claim 1, wherein the change in the physical property of the body is responsive to a change in pH.
8. A method comprising:
introducing a physiological sensor including a biocompatible body into contact with a tissue, wherein the body includes at least one physical property that changes as a result of the contact with the tissue in response to a physiological change associated with the tissue, the physiological change predictive or indicative of a tachyarrhythmia;
transmitting acoustic energy to the body and the tissue;
receiving transmitted acoustic energy for detecting the change in the physical property of the body; and
detecting and providing an indication of the physiological change by detecting the change in the physical property of the body.
9. The method of claim 8, wherein introducing the physiological sensor includes introducing a pH sensitive biocompatible body.
10. The method of claim 8, wherein introducing the physiological sensor includes introducing an ion sensitive biocompatible body.
11. The method of claim 8, wherein introducing the physiological sensor includes introducing a catheter.
12. The method of claim 8, wherein introducing the physiological sensor includes introducing a sphere.
13. The method of claim 8, comprising introducing a device for transmitting the acoustic energy.
14. The method of claim 8, comprising introducing a device for receiving the transmitted acoustic energy.
15. The method of claim 8, wherein transmitting the acoustic energy includes transmitting the acoustic energy using an implantable transducer.
16. An apparatus comprising:
a physiological sensor including a biocompatible body, the body sized and shaped to be implanted within a subject to contact tissue, at least a portion of the body including a material having at least one physical property that changes in response to a physiological condition of the tissue when that portion of the body is implanted in contact with the tissue, the change in the physiological condition being predictive or indicative of ischemia, wherein the change in the at least one physical property occurs because of the contact between that portion and the tissue, wherein the portion of the body is sized and shaped such that the change in the physical property is detectable using acoustic energy to provide an indication of the physiological condition.
17. The apparatus of claim 16, comprising an implantable transducer configured to supply the acoustic energy for providing the indication of the physiological condition.
18. The apparatus of claim 16, wherein the change in the physical property of the body includes a change in size of the body.
19. The apparatus of claim 16, wherein the change in the physical property of the body includes a change in an acoustic property of the body.
20. The apparatus of claim 16, wherein the change in the physical property of the body is responsive to a change in pH.
Description
    CROSS REFERENCE TO RELATED APPLICATION
  • [0001]
    This application is a continuation of U.S. application Ser. No. 10/648,837, filed Aug. 26, 2003, which is hereby incorporated by reference in its entirety.
  • TECHNICAL FIELD
  • [0002]
    This document relates generally to medical systems, devices, and methods, and particularly, but not by way of limitation, to an acoustic physiological sensor.
  • BACKGROUND
  • [0003]
    Physiological conditions of a subject can provide useful information about the subject's health status to a physician or other caregiver. For example, portions of a heart muscle that receive inadequate blood circulation may become ischemic. There is a need for improved techniques of invasively or noninvasively measuring changes in a physiological condition indicative of ischemia.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0004]
    In the drawings, which are not necessarily drawn to scale, like numerals describe substantially similar components throughout the several views. Like numerals having different letter suffixes represent different instances of substantially similar components. The drawings illustrate generally, by way of example, but not by way of limitation, various embodiments discussed in the present document.
  • [0005]
    FIG. 1 is a schematic diagram illustrating generally one example of a system to detect a change in at least one physiological condition of a tissue, such as a heart.
  • [0006]
    FIG. 2 is a flow chart illustrating generally a method of providing an indication of a physiological condition, such as by using the system of FIG. 1, or other desired system.
  • [0007]
    FIG. 3 is a conceptual schematic diagram illustrating generally a swelling of a spherical body from non-ischemic to ischemic conditions.
  • [0008]
    FIG. 4 is a conceptual schematic diagram illustrating generally a swelling of a body that changes its physical property of morphology, shape, or stiffness from non-ischemic to ischemic conditions.
  • [0009]
    FIG. 5 is a schematic diagram, similar to FIG. 1, but illustrating a plurality of spherical or other bodies positioned at desired myocardial locations, such as described above.
  • [0010]
    FIG. 6 is a schematic diagram, similar to FIG. 5, but illustrating an example of a second intravascular lead catheter.
  • DETAILED DESCRIPTION
  • [0011]
    In the following detailed description, reference is made to the accompanying drawings which form a part hereof, and in which is shown by way of illustration specific embodiments in which the invention may be practiced. These embodiments, which are also referred to herein as “examples,” are described in sufficient detail to enable those skilled in the art to practice the invention, and it is to be understood that the embodiments may be combined, or that other embodiments may be utilized and that structural, logical and electrical changes may be made without departing from the scope of the present invention. The following detailed description is, therefore, not to be taken in a limiting sense, and the scope of the present invention is defined by the appended claims and their equivalents.
  • [0012]
    In this document, the terms “a” or “an” are used, as is common in patent documents, to include one or more than one. In this document, the term “or” is used to refer to a “nonexclusive or,” unless otherwise indicated. Furthermore, all publications, patents, and patent documents referred to in this document are incorporated by reference herein in their entirety, as though individually incorporated by reference. In the event of inconsistent usages between this documents and those documents so incorporated by reference, the usage in the incorporated reference(s) should be considered supplementary to that of this document; for irreconcilable inconsistencies, the usage in this document controls.
  • [0013]
    FIG. 1 is a schematic diagram illustrating generally, by way of example, but not by way of limitation, one example of a system 100 to detect a change in at least one physiological condition of a tissue, such as tissue of a heart 102. In this example, the system includes an ultrasound or other acoustic transducer 104, which is disposed within or near the heart 102, or any other region of interest. In this example, a sphere or other body 106 is also disposed within or near the heart 102 or other region of interest, such as near the transducer 104. In this example, but not by way of limitation, the transducer 104 is located on an intracardiac lead 108, which is coupled to an implantable cardiac rhythm management (CRM) or other device 110. In one example, the spherical body 106 includes a diameter approximately between 1 micrometer and 50 micrometers, such as about 20 micrometers.
  • [0014]
    In this example, the device 110 includes a signal processor circuit 112. The signal processor circuit 112 is coupled to the transducer 104 to process an ultrasound or other acoustic signal received from the transducer 104. In this example, the device 110 also includes a controller circuit 114. The controller circuit 114 is coupled to the transducer 104 to provide at least one control signal to the transducer 104. In this example, the controller circuit 114 is also coupled to the signal processor circuit 112, such as to digitally perform additional processing on the acoustic signal. In this example, the device 110 includes a telemetry or other communication circuit 116. The communication circuit 116 is coupled to the controller circuit 114, such as to receive information about a change in at least one physiological condition of the heart 102 or other tissue or region of interest, where the change in the physiological condition is detected using an acoustic determination of a change in a physical property of the body 106. The communication circuit 116 is communicatively couplable to an external user interface 118, such as for transmitting an indication of the physical property, the change in the physical property, the physiological condition, or the change in the physiological condition for display to a user and/or recording. In one example, the external user interface 118 includes a nearby external programmer. In another example, the external user interface 118 includes an a computer network-linked (e.g., internet linked) and/or telephone network-linked more distant advanced patient management system capable of storing and/or displaying patient data and/or performing other functions. In one example, the external user interface 118 includes a short range communication circuit for communication with the implantable device 110 and an internet-linked or other long range communication circuit to communicate with an patient management computer server.
  • [0015]
    FIG. 2 is a flow chart illustrating generally, by way of example, but not by way of limitation, a method of providing an indication of a physiological condition, such as by using the system of FIG. 1 or other desired system. In the example of FIG. 2, at 200, the transducer 104 and the body 106 are disposed near the local region of tissue for which the indication of the physiological condition is desired. In one example, this includes intravascularly introducing an ultrasound transducer 104 into a right ventricular chamber of the heart 102, such as by using an intracardiac lead 108. In one example, this also includes intravascularly introducing a small spherical or other body 106 into coronary vasculature, such as via the coronary arteries or veins, to position the body 106 into contact with a local region of a microcirculatory myocardial tissue bed for which an ischemia determination is desired.
  • [0016]
    At 202, the transducer 104 transmits acoustic energy. In this example, the transmitted acoustic energy is reflected by the body 106. The reflected acoustic energy is received at the same (or different) transducer 104. The received acoustic energy is processed to obtain a first reading of a physiological condition using a physical property of the body 106.
  • [0017]
    At 204, a physical property of the body 106 changes in response to a physiological condition. In one illustrative example, the size of a spherical body 106 changes in response to the physiological condition of ischemia. Ischemia results from a decreased blood flow to the heart tissue. This reduced blood flow produces several physiological effects in the extra-cellular portion of the ischemic tissue. For instance, the extra-cellular space would undergo a slight decrease in sodium (Na+) ions, a substantial increase in potassium (K+) ions, an increase in calcium (Ca++) ions, and a decreased pH due to accumulation of metabolic waste (e.g., particularly an increase in percentage carbon dioxide (pCO2) and a decreased percentage oxygen (pO2). In one example, the spherical or other at least one body 106 responds to the change in pH, and is constructed using a pH sensitive polymer. As a result of the decreased pH during ischemia, the body 106 adsorbs water or other bodily fluids and swells, such as illustrated in FIG. 3. This change in a physical property of the body 106 is acoustically detectable. It is believed that a 10% change in diameter of the spherical body 106 will increase the frequency of reflected acoustic energy by about 10% (e.g., from 20 MHz to 22 MHz).
  • [0018]
    At 206, the transducer 104 transmits and receives acoustic energy to obtain a second reading of a physiological condition (e.g., ischemia) using this change in a physical property (e.g., size and acoustic reflectance) of the body 106. A difference between the first and second readings permits the detection of any change in the physiological condition.
  • [0019]
    At 208, the system provides an indication of the physiological condition and/or a change in the physiological condition using any detected change in the physical property of the body 106.
  • [0020]
    FIG. 3 is a conceptual schematic diagram illustrating generally, by way of example, but not by way of limitation, a swelling of a spherical body 106 from non-ischemic to ischemic conditions, thereby increasing the frequency at which acoustic energy is reflected from the spherical body 106.
  • [0021]
    FIG. 4 is a conceptual schematic diagram illustrating generally, by way of example, but not by way of limitation, a swelling of a body 400 (which need not be spherical). In this example, the swelling changes its physical property of morphology, shape, or stiffness from non-ischemic to ischemic conditions, thereby increasing the frequency at which acoustic energy is reflected from the body 400. In one example, the body 400 is constructed from a pH sensitive polymer or other pH sensitive material, as discussed above, to obtain the change in morphology, shape, or stiffness. In another example, the body 400 is constructed of an ion-selective membrane enclosure defining its shape. Ischemia results in an altered local concentration of sodium (Na+), potassium (K+), and calcium (Ca++). During ischemia, one or more of these variety of ions are accepted from the local environment across the membrane enclosure to within the body 400. The resulting swelling of the body 400 causes an acoustically detectable change in shape.
  • [0022]
    FIG. 5 is a schematic diagram, similar to FIG. 1, but illustrating generally, by way of example, but not by way of limitation, a plurality of spherical or other bodies 500 positioned at desired myocardial locations, such as described above. This permits detection of a change in physiological condition over a broader region. Moreover, although the above description has generally emphasized detecting a change in physiological condition by using a change in acoustic reflectance due to a change in a physical property (e.g., size and/or shape) of the body, other techniques could rely on a change in acoustic transmission, acoustic attenuation, and/or acoustic transit time, and/or any other acoustic technique. In one example, the device 110 includes a second acoustic transducer 502 (e.g., carried within a hermetically-sealed housing enclosure of the implantable device 110, or disposed on a second intravascular catheter). In this example, acoustic energy is transmitted from the first transducer 104 and received at the second transducer 502 (or vice versa). The bodies 500 are positioned acoustically in between the transducers 104 and 502. A change in physiological condition (e.g., ischemia) alters the acoustic transmission and/or attenuation between the transducers. This is measured by the signal processor circuit 112 and the controller circuit 114.
  • [0023]
    FIG. 6 is a schematic diagram, similar to FIG. 5, but illustrating generally, by way of example, but not by way of limitation, a second intravascular lead catheter 600. The second intravascular lead catheter 600 includes one or more bodies 602 that swell or otherwise alter an acoustically detectable physical property in response to a change in a physiological condition, such as described above. In one example, the catheter 600 is introduced into a coronary sinus and/or great cardiac vein, such as to position the bodies 602 in contact with a myocardial tissue region of interest. Acoustic detection is performed either using the single transducer 104, as described above, or by using two transducers 104 and 502, as also described above. Alternatively, the second intravascular lead catheter provides an appropriate electrical connection to the one or more bodies 602 that swell or otherwise alter a physical property, thereby changing an electrical property (e.g., a bridge or other resistance, capacitance, etc.) incorporated within the one or more bodies 602. In this example, the ischemia or other physiological condition is detected electrically instead of acoustically.
  • [0024]
    In one example, a change in physiologic condition (e.g., ischemia) is determined from the acoustic response of the spherical or other body or bodies 602 to a change in the physiologic condition. The acoustic response is compared to a baseline acoustic response. If the acoustic response deviates from the baseline acoustic response by an amount that is greater than a predetermined threshold value, then a detected change in the physiologic condition (e.g., ischemia) is declared. In one example, the detected change in the physiologic condition is stored and/or communicated to the remote user interface 118 for storage and/or display or other presentation to the user. In one example, the detected change in the physiologic condition is used in conjunction with an alarm to alert the physician and/or the clinician (e.g., that the patient is undergoing an ischemic episode).
  • [0025]
    In another example, the detected change in the physiologic condition is used to initiate or modify therapy being delivered by the implantable cardiac rhythm management device 110. For example, if a detected ischemia episode was preceded by a time period during which pacing pulses were delivered at a relatively higher average rate, then, in one example, the pacing rate is reduced. In another example, such as where multiple pacing electrodes are disposed at different locations about the heart, the locations or sequence of delivery of pacing pulses from such locations is altered, such as to shift blood toward the ischemic area of the heart tissue. In a further example, the change in the physiologic condition is used as a factor that is predictive of the occurrence of a future episode of cardiac arrhythmia, such as fibrillation. One example of using factor(s) predictive of future arrhythmias (as well as taking preventative measures) is described in Robert J. Sweeney et al. U.S. Pat. No. 6,272,377 entitled CARDIAC RHYTHM MANAGEMENT SYSTEM WITH ARRHYTHMIA PREDICTION AND PREVENTION, which is assigned to Cardiac Pacemakers, Inc., and which is incorporated by reference herein in its entirety, including its disclosure of devices and methods for predicting and preventing future arrhythmias. In one example, the detected change in the physiologic condition is used to alter the state of the cardiac rhythm management device 110 in anticipation of a future physiologic event. For example, the device 110 could monitor the subject with greater time resolution during an ischemia episode, or could pre-charge defibrillation capacitors to more readily deliver a defibrillation pulse.
  • [0026]
    Although the above examples have emphasized use of an implantable device 110, such as for obtaining chronic measurements, alternatively, each of these examples is implemented with an external device, operating similarly.
  • [0027]
    It is to be understood that the above description is intended to be illustrative, and not restrictive. For example, aspects of the above-described embodiments may be used in combination with each other. Many other embodiments will be apparent to those of skill in the art upon reviewing the above description. The scope of the invention should, therefore, be determined with reference to the appended claims, along with the full scope of equivalents to which such claims are entitled. In the appended claims, the terms “including” and “in which” are used as the plain-English equivalents of the respective terms “comprising” and “wherein.” Moreover, in the following claims, the terms “first,” “second,” and “third,” etc. are used merely as labels, and are not intended to impose numerical requirements on their objects.
Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US4345588 *Jun 27, 1980Aug 24, 1982Northwestern UniversityMethod of delivering a therapeutic agent to a target capillary bed
US4492753 *Oct 6, 1982Jan 8, 1985Immudx, Inc.Method and means for assessment and prediction of risk of subsequent ischemic cardiac events
US4703756 *May 6, 1986Nov 3, 1987The Regents Of The University Of CaliforniaComplete glucose monitoring system with an implantable, telemetered sensor module
US4849210 *Aug 11, 1987Jul 18, 1989Molecular Biosystems, Inc.Magnetic resonance imaging of liver and spleen with superparamagnetic contrast agents
US5062841 *Nov 14, 1989Nov 5, 1991The Regents Of The University Of CaliforniaImplantable, self-regulating mechanochemical insulin pump
US5156154 *Mar 8, 1991Oct 20, 1992Telectronics Pacing Systems, Inc.Monitoring the hemodynamic state of a patient from measurements of myocardial contractility using doppler ultrasound techniques
US5161536 *Mar 22, 1991Nov 10, 1992Catheter TechnologyUltrasonic position indicating apparatus and methods
US5188106 *Mar 8, 1991Feb 23, 1993Telectronics Pacing Systems, Inc.Method and apparatus for chronically monitoring the hemodynamic state of a patient using doppler ultrasound
US5199428 *Mar 22, 1991Apr 6, 1993Medtronic, Inc.Implantable electrical nerve stimulator/pacemaker with ischemia for decreasing cardiac workload
US5305745 *Apr 2, 1992Apr 26, 1994Fred ZacoutoDevice for protection against blood-related disorders, notably thromboses, embolisms, vascular spasms, hemorrhages, hemopathies and the presence of abnormal elements in the blood
US5324297 *Mar 5, 1991Jun 28, 1994Advanced Osseous Technologies, Inc.Ultrasonic tool connector
US5445155 *Jul 13, 1994Aug 29, 1995Scimed Life Systems IncorporatedIntravascular imaging apparatus and methods for use and manufacture
US5843156 *May 6, 1994Dec 1, 1998Endoluminal Therapeutics, Inc.Local polymeric gel cellular therapy
US6123923 *Dec 18, 1997Sep 26, 2000Imarx Pharmaceutical Corp.Optoacoustic contrast agents and methods for their use
US6272377 *Oct 1, 1999Aug 7, 2001Cardiac Pacemakers, Inc.Cardiac rhythm management system with arrhythmia prediction and prevention
US6296630 *Feb 25, 1999Oct 2, 2001Biocardia, Inc.Device and method to slow or stop the heart temporarily
US6315981 *Mar 19, 1999Nov 13, 2001Imarx Therapeutics, Inc.Gas filled microspheres as magnetic resonance imaging contrast agents
US6322515 *Jun 2, 1999Nov 27, 2001Itamar MedicalMethod and apparatus for the non-invasive detection of medical conditions by monitoring peripheral arterial tone
US6328700 *Jul 9, 1999Dec 11, 2001Christopher RheinhardtLocating marker/tracer elements detectable by neutron activated analysis within or on carrier microspheres, including microspheres used in biological experimentation
US6348186 *Jun 5, 1995Feb 19, 2002Quadrant Healthcare (Uk) LimitedPreparation of further diagnostic agents
US6350463 *May 21, 1999Feb 26, 2002Andre BieniarzMethod of treatment for premature rupture of membranes in pregnancy (PROM)
US6368284 *Nov 16, 1999Apr 9, 2002Cardiac Intelligence CorporationAutomated collection and analysis patient care system and method for diagnosing and monitoring myocardial ischemia and outcomes thereof
US6409674 *Sep 24, 1998Jun 25, 2002Data Sciences International, Inc.Implantable sensor with wireless communication
US6416740 *May 11, 1998Jul 9, 2002Bristol-Myers Squibb Medical Imaging, Inc.Acoustically active drug delivery systems
US6421565 *Jul 30, 1998Jul 16, 2002Pacesetter AbCardiac monitoring device and a rate responsive pacemaker system
US6468263 *May 21, 2001Oct 22, 2002Angel Medical Systems, Inc.Implantable responsive system for sensing and treating acute myocardial infarction and for treating stroke
US6537246 *Jun 18, 1997Mar 25, 2003Imarx Therapeutics, Inc.Oxygen delivery agents and uses for the same
US6645147 *Nov 25, 1998Nov 11, 2003Acuson CorporationDiagnostic medical ultrasound image and system for contrast agent imaging
US6666811 *Aug 7, 2000Dec 23, 2003Endotech, Inc.Endocurietherapy
US6750030 *Apr 22, 2002Jun 15, 2004Torrey Pines Institute For Molecular StudiesMethod of detecting cardiac ischemia using fatty acid binding protein
US6751491 *Jan 22, 2002Jun 15, 2004M Biotech IncAnalyte measuring biosensor chip using image scanning system
US6770032 *Dec 2, 2002Aug 3, 2004Microsense Cardiovascular Systems 1996Passive ultrasonic sensors, methods and systems for their use
US6810286 *Mar 5, 2001Oct 26, 2004Medtronic, IncStimulation for delivery of molecular therapy
US6827690 *Apr 4, 2002Dec 7, 2004Cardiac Intelligence CorporationSystem and method for providing diagnosis and monitoring of myocardial ischemia for use in automated patient care
US6939530 *Jun 21, 2002Sep 6, 2005Quadrant Drug Delivery LimitedPreparation of further diagnostic agents
US7078015 *Nov 8, 2004Jul 18, 2006Imarx Therapeutics, Inc.Ultrasound imaging and treatment
US7083572 *Mar 26, 2002Aug 1, 2006Bristol-Myers Squibb Medical Imaging, Inc.Therapeutic delivery systems
US7299087 *Jun 24, 2004Nov 20, 2007Cardiac Intelligence CorporationSystem and method for analyzing a patient status for myocardial ischemia for use in automated patient care
US7311731 *Oct 24, 2002Dec 25, 2007Richard C. SatterfieldPrevention of myocardial infarction induced ventricular expansion and remodeling
US7479112 *Aug 26, 2003Jan 20, 2009Cardiac Pacemakers, Inc.Acoustic physiological sensor
US7577478 *Feb 1, 2006Aug 18, 2009Pacesetter, Inc.Ischemia detection for anti-arrhythmia therapy
US20020111551 *Nov 30, 2000Aug 15, 2002Erlach Julian VanMethod for detecting body condition using nano and microdevices
US20020119441 *Feb 20, 2002Aug 29, 2002Cytokinetics, Inc., A Delaware CorporationMethod of characterizing potential therapeutics by determining cell-cell interactions
US20020176849 *Feb 8, 2002Nov 28, 2002Endoluminal Therapeutics, Inc.Endomural therapy
US20030004549 *Oct 26, 2001Jan 2, 2003Medtronic, Inc.Method and apparatus to minimize the effects of a cardiac insult
US20030100822 *Jan 22, 2002May 29, 2003Seok LewAnalyte measuring biosensor chip using image scanning system
US20040215049 *Jan 23, 2004Oct 28, 2004Proteus Biomedical, Inc.Method and system for remote hemodynamic monitoring
US20040258614 *Jan 23, 2004Dec 23, 2004University Of Maryland, BaltimoreMicroparticles for microarterial imaging and radiotherapy
US20040260346 *Jan 30, 2004Dec 23, 2004Overall William RyanDetection of apex motion for monitoring cardiac dysfunction
US20050049492 *Aug 26, 2003Mar 3, 2005Sweeney Robert J.Acoustic physiological sensor
US20050107870 *Aug 20, 2004May 19, 2005Xingwu WangMedical device with multiple coating layers
US20050159789 *Mar 14, 2005Jul 21, 2005Transoma Medical, Inc.Implantable sensor with wireless communication
US20050234336 *Mar 26, 2004Oct 20, 2005Beckman Andrew TApparatus and method for marking tissue
US20060015146 *Jul 14, 2004Jan 19, 2006Girouard Steven DMethod and apparatus for controlled gene or protein delivery
US20060015178 *Jul 14, 2005Jan 19, 2006Shahram MoaddebImplants and methods for reshaping heart valves
US20060229594 *Dec 9, 2005Oct 12, 2006Medtronic, Inc.Method for guiding a medical device
US20060251582 *May 9, 2006Nov 9, 2006Biosphere Medical SaCompositions and methods using microspheres and non-ionic contrast agents
US20070010702 *Jun 30, 2005Jan 11, 2007Xingwu WangMedical device with low magnetic susceptibility
US20070015981 *Jun 12, 2006Jan 18, 2007Benaron David ADevice and methods for the detection of locally-weighted tissue ischemia
US20070150015 *Dec 23, 2005Jun 28, 2007Yi ZhangImplantable cardiac device with ischemia response capability
US20070276453 *Aug 13, 2007Nov 29, 2007Hill Michael RMethod and apparatus to minimize the effects of a cardiac insult
US20080058661 *Oct 31, 2007Mar 6, 2008Bardy Gust HSystem And Method For Automated Diagnosis Of Myocardial Ischemia Through Remote Monitoring
US20080097227 *Jul 27, 2007Apr 24, 2008Zdeblick Mark JMethod and system for remote hemodynamic monitoring
US20080177194 *Jan 19, 2007Jul 24, 2008Cardiac Pacemakers, Inc.Heart attack detector
US20080183062 *Feb 23, 2005Jul 31, 2008Hiroshi HazuiMethod of Distinguishing Among Type a and Type B Acute Aortic Dissection and Acute Myocardial Infraction and Kit For Distinguishment
US20080312519 *Jun 10, 2008Dec 18, 2008Siemens AktiengesellschaftExamination unit with an integrated mini-laboratory analysis unit
US20090137890 *Nov 27, 2007May 28, 2009Burnes John EDevices to monitor glucose levels and ischemia
US20090171228 *Feb 6, 2009Jul 2, 2009Angel Medical Systems, Inc.Baseline processing for the detection of cardiac events
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US7668594Aug 19, 2005Feb 23, 2010Cardiac Pacemakers, Inc.Method and apparatus for delivering chronic and post-ischemia cardiac therapies
US7774061Dec 23, 2005Aug 10, 2010Cardiac Pacemakers, Inc.Implantable cardiac device with ischemia response capability
US7885710Dec 23, 2005Feb 8, 2011Cardiac Pacemakers, Inc.Method and apparatus for tissue protection against ischemia using remote conditioning
US7917210May 13, 2005Mar 29, 2011Cardiac Pacemakers, Inc.Method and apparatus for cardiac protection pacing
US8000780Jun 27, 2006Aug 16, 2011Cardiac Pacemakers, Inc.Detection of myocardial ischemia from the time sequence of implanted sensor measurements
US8014863Jan 19, 2007Sep 6, 2011Cardiac Pacemakers, Inc.Heart attack or ischemia detector
US8275457Nov 24, 2009Sep 25, 2012Angel Medical Systems, Inc.Cardiac monitoring system for paced patients having paced and non-paced ischemia detection thresholds
US8306615Jan 18, 2010Nov 6, 2012Cardiac Pacemakers, Inc.Method and apparatus for delivering chronic and post-ischemia cardiac therapies
US8340764Feb 17, 2011Dec 25, 2012Cardiac Pacemakers, Inc.Method and apparatus for cardiac protection pacing
US8412326Feb 22, 2010Apr 2, 2013Cardiac Pacemakers, Inc.Pacemaker with vagal surge monitoring and response
US8452404Nov 24, 2009May 28, 2013Angel Medical Systems, Inc.Ischemia detection systems for paced-patients having three different detection modes
US8615296Mar 6, 2007Dec 24, 2013Cardiac Pacemakers, Inc.Method and apparatus for closed-loop intermittent cardiac stress augmentation pacing
US8758260Sep 13, 2011Jun 24, 2014Cardiac Pacemakers, Inc.Ischemia detection using a heart sound sensor
US8805498Nov 24, 2009Aug 12, 2014Angel Medical Systems, Inc.Ischemia detection systems for paced-patients using beat-type dependent baseline datasets
US8812104Sep 8, 2010Aug 19, 2014Cardiac Pacemakers, Inc.Method and apparatus for automated control of pacing post-conditioning
US8830037 *Dec 31, 2009Sep 9, 2014The Regents Of The University Of CaliforniaIn vivo RFID chip
US8855762Dec 20, 2012Oct 7, 2014Cardiac Pacemakers, Inc.Method and apparatus for cardiac protection pacing
US8903487Nov 24, 2009Dec 2, 2014Angel Medical Systems, Inc.Pacemaker enabled ischemia detection with selective ischemia tests
US8958873Apr 29, 2010Feb 17, 2015Cardiac Pacemakers, Inc.Method and apparatus for safe and efficient delivery of cardiac stress augmentation pacing
US8983600Apr 28, 2010Mar 17, 2015Cardiac Pacemakers, Inc.Method and apparatus for safety control during cardiac pacing mode transition
US9415228Sep 14, 2015Aug 16, 2016Angel Medical Systems, Inc.System for ischemia detection based on adjustable paced beat analysis timing
US20060259087 *May 13, 2005Nov 16, 2006Baynham Tamara CMethod and apparatus for cardiac protection pacing
US20070043393 *Aug 19, 2005Feb 22, 2007Cardiac Pacemakers, Inc.Method and apparatus for delivering chronic and post-ischemia cardiac therapies
US20070150005 *Dec 23, 2005Jun 28, 2007Sih Haris JMethod and apparatus for tissue protection against ischemia using remote conditioning
US20070150015 *Dec 23, 2005Jun 28, 2007Yi ZhangImplantable cardiac device with ischemia response capability
US20080081354 *Oct 2, 2006Apr 3, 2008Cardiac Pacemakers, Inc.Devices, vectors and methods for inducible ischemia cardioprotection
US20080177194 *Jan 19, 2007Jul 24, 2008Cardiac Pacemakers, Inc.Heart attack detector
US20080221636 *Mar 6, 2007Sep 11, 2008Cardiac Pacemakers, Inc.Method and apparatus for closed-loop intermittent cardiac stress augmentation pacing
US20100171596 *Dec 31, 2009Jul 8, 2010Burke Peter JIn vivo rfid chip
US20100305648 *Apr 29, 2010Dec 2, 2010Shantha Arcot-KrishnamurthyMethod and apparatus for safe and efficient delivery of cardiac stress augmentation pacing
US20100312130 *Aug 20, 2010Dec 9, 2010Yi ZhangGraded response to myocardial ischemia
US20110071584 *Sep 8, 2010Mar 24, 2011Mokelke Eric AMethod and apparatus for automated control of pacing post-conditioning
US20110106197 *Feb 22, 2010May 5, 2011Shantha Arcot-KrishnamurthyPacemaker with vagal surge monitoring and response
US20110144709 *Feb 17, 2011Jun 16, 2011Tamara Colette BaynhamMethod and apparatus for cardiac protection pacing
Classifications
U.S. Classification600/528
International ClassificationA61N1/365, A61B5/02, A61N1/368, A61B7/00, A61N1/362
Cooperative ClassificationA61N1/3622, A61N1/36557, A61N1/3684, A61B7/00
European ClassificationA61N1/365B8, A61B7/00