US20100130743A1 - Heterocycle-substituted, n-phenyl-phthalamide derivatives, related compounds and their use as insecticides - Google Patents
Heterocycle-substituted, n-phenyl-phthalamide derivatives, related compounds and their use as insecticides Download PDFInfo
- Publication number
- US20100130743A1 US20100130743A1 US12/694,441 US69444110A US2010130743A1 US 20100130743 A1 US20100130743 A1 US 20100130743A1 US 69444110 A US69444110 A US 69444110A US 2010130743 A1 US2010130743 A1 US 2010130743A1
- Authority
- US
- United States
- Prior art keywords
- methyl
- isomer
- formula
- soch
- sch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 CC.C[Y].[1*]NC(=O)C1=CC=CC=C1C(=O)NC1=CC=C(C)C=C1 Chemical compound CC.C[Y].[1*]NC(=O)C1=CC=CC=C1C(=O)NC1=CC=C(C)C=C1 0.000 description 16
- USJKUSSNDHCXEP-UHFFFAOYSA-N CC1=CC=C(N)C=C1.C[Y] Chemical compound CC1=CC=C(N)C=C1.C[Y] USJKUSSNDHCXEP-UHFFFAOYSA-N 0.000 description 5
- AGGYMHATNSBJLS-UHFFFAOYSA-N CCC1=CC=C([N+](=O)[O-])C=C1.C[Y] Chemical compound CCC1=CC=C([N+](=O)[O-])C=C1.C[Y] AGGYMHATNSBJLS-UHFFFAOYSA-N 0.000 description 3
- INCDGFBFYSZGFN-BIZPNDHSSA-N CC.CC1=CC=C(/N=C2\OC(=O)C3=CC=CC=C32)C=C1.C[Y] Chemical compound CC.CC1=CC=C(/N=C2\OC(=O)C3=CC=CC=C32)C=C1.C[Y] INCDGFBFYSZGFN-BIZPNDHSSA-N 0.000 description 2
- KNCUSPWFFYTVFV-UHFFFAOYSA-N CC.CC1=CC=C(N2C(=O)C3=CC=CC=C3C2=O)C=C1.C[Y] Chemical compound CC.CC1=CC=C(N2C(=O)C3=CC=CC=C3C2=O)C=C1.C[Y] KNCUSPWFFYTVFV-UHFFFAOYSA-N 0.000 description 2
- MAWAQKPEVSUWTA-UHFFFAOYSA-N CC.CC1=CC=C(NC(=O)C2=CC=CC=C2C(=O)O)C=C1.C[Y] Chemical compound CC.CC1=CC=C(NC(=O)C2=CC=CC=C2C(=O)O)C=C1.C[Y] MAWAQKPEVSUWTA-UHFFFAOYSA-N 0.000 description 2
- VISVSMBOZNEAJH-UHFFFAOYSA-N CC.O=C1OC(=O)C2=CC=CC=C12 Chemical compound CC.O=C1OC(=O)C2=CC=CC=C12 VISVSMBOZNEAJH-UHFFFAOYSA-N 0.000 description 2
- JBDXUVCZDJPNSY-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(C2=NNC(=O)C2)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(C2=NNC(=O)C2)=C1 JBDXUVCZDJPNSY-UHFFFAOYSA-N 0.000 description 2
- HSSFJJMCNKPKPA-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(CNN)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(CNN)=C1 HSSFJJMCNKPKPA-UHFFFAOYSA-N 0.000 description 2
- OJOAHUPDDXCEAW-UHFFFAOYSA-N CC1=CC(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)=CC=C1N Chemical compound CC1=CC(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)=CC=C1N OJOAHUPDDXCEAW-UHFFFAOYSA-N 0.000 description 2
- XNCIFHBAFJULFT-UHFFFAOYSA-N CC1=CN(CC2=CC(C)=C([N+](=O)[O-])C=C2)N=C1C(F)(F)F Chemical compound CC1=CN(CC2=CC(C)=C([N+](=O)[O-])C=C2)N=C1C(F)(F)F XNCIFHBAFJULFT-UHFFFAOYSA-N 0.000 description 2
- ZLCOUHIZUXDZFC-AWEZNQCLSA-N CSC[C@H](C)NC(=O)C1=C(F)C=CC=C1C(=O)NC1=CC=C(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)C=C1C Chemical compound CSC[C@H](C)NC(=O)C1=C(F)C=CC=C1C(=O)NC1=CC=C(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)C=C1C ZLCOUHIZUXDZFC-AWEZNQCLSA-N 0.000 description 2
- UYTCYIXWTOXLLE-UHFFFAOYSA-N CC(F)F.CC1=C([N+](=O)[O-])C=CC(CC2=C(C(F)(F)F)NN=C2OC(F)F)=C1.CC1=C([N+](=O)[O-])C=CC(CC2=C(OC(F)F)N(C(F)F)N=C2C(F)(F)F)=C1 Chemical compound CC(F)F.CC1=C([N+](=O)[O-])C=CC(CC2=C(C(F)(F)F)NN=C2OC(F)F)=C1.CC1=C([N+](=O)[O-])C=CC(CC2=C(OC(F)F)N(C(F)F)N=C2C(F)(F)F)=C1 UYTCYIXWTOXLLE-UHFFFAOYSA-N 0.000 description 1
- CSVHZTDOWSSNCM-FDRCHMJRSA-N CC.CCC1=CC=C(/N=C2\OC(=O)C3=CC=CC=C32)C=C1.C[Y] Chemical compound CC.CCC1=CC=C(/N=C2\OC(=O)C3=CC=CC=C32)C=C1.C[Y] CSVHZTDOWSSNCM-FDRCHMJRSA-N 0.000 description 1
- QBKNVRZWDWFLDP-UHFFFAOYSA-N CC1=C(I)NN=C1I Chemical compound CC1=C(I)NN=C1I QBKNVRZWDWFLDP-UHFFFAOYSA-N 0.000 description 1
- SGTMOGGRUXSKOG-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(C(=O)CC(=O)C(F)(F)F)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(C(=O)CC(=O)C(F)(F)F)=C1 SGTMOGGRUXSKOG-UHFFFAOYSA-N 0.000 description 1
- XCIHHSZRLJVNMT-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(C(C)N2C=CC(C(F)(F)F)=N2)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(C(C)N2C=CC(C(F)(F)F)=N2)=C1 XCIHHSZRLJVNMT-UHFFFAOYSA-N 0.000 description 1
- RDKJCECHERUBNO-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(C(C)N2N=C(C#C(F)(F)(F)(F)F)N=C2C(F)(F)F)=C1.CC1=C([N+](=O)[O-])C=CC(C(C)N2N=C(C(F)(F)F)N=C2C#C(F)(F)(F)(F)F)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(C(C)N2N=C(C#C(F)(F)(F)(F)F)N=C2C(F)(F)F)=C1.CC1=C([N+](=O)[O-])C=CC(C(C)N2N=C(C(F)(F)F)N=C2C#C(F)(F)(F)(F)F)=C1 RDKJCECHERUBNO-UHFFFAOYSA-N 0.000 description 1
- KVCZQNLHBTXZJY-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(C(C)O)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(C(C)O)=C1 KVCZQNLHBTXZJY-UHFFFAOYSA-N 0.000 description 1
- BOXFPQDWLFBNTA-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(C(C)OS(C)(=O)=O)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(C(C)OS(C)(=O)=O)=C1 BOXFPQDWLFBNTA-UHFFFAOYSA-N 0.000 description 1
- JNIUADKBTWIUEI-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(C2=CC(C(F)(F)F)=NN2CC(F)(F)F)=C1.CC1=C([N+](=O)[O-])C=CC(C2=NN(C(F)(F)C(F)(F)F)C(C(F)(F)F)=C2)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(C2=CC(C(F)(F)F)=NN2CC(F)(F)F)=C1.CC1=C([N+](=O)[O-])C=CC(C2=NN(C(F)(F)C(F)(F)F)C(C(F)(F)F)=C2)=C1 JNIUADKBTWIUEI-UHFFFAOYSA-N 0.000 description 1
- UWFILUSNWKMELF-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(C2=CC(OC(F)F)=NN2C(F)F)=C1.CC1=C([N+](=O)[O-])C=CC(C2=NN(C(F)F)C(OC(F)F)=C2)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(C2=CC(OC(F)F)=NN2C(F)F)=C1.CC1=C([N+](=O)[O-])C=CC(C2=NN(C(F)F)C(OC(F)F)=C2)=C1 UWFILUSNWKMELF-UHFFFAOYSA-N 0.000 description 1
- IUIAHBRZTSRENI-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(CC2C(=O)NN=C2C(F)(F)F)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(CC2C(=O)NN=C2C(F)(F)F)=C1 IUIAHBRZTSRENI-UHFFFAOYSA-N 0.000 description 1
- CBSHNWHKJMIQPR-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(CN2C=C(Br)C(C(F)(F)F)=N2)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(CN2C=C(Br)C(C(F)(F)F)=N2)=C1 CBSHNWHKJMIQPR-UHFFFAOYSA-N 0.000 description 1
- BESGCUXOYBSAJR-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(CN2C=C(C#C(F)(F)(F)(F)F)C=C2C(=O)C(F)(F)F)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(CN2C=C(C#C(F)(F)(F)(F)F)C=C2C(=O)C(F)(F)F)=C1 BESGCUXOYBSAJR-UHFFFAOYSA-N 0.000 description 1
- PRXXPQIHAADQGI-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(CN2C=C(C(F)(F)F)C(C#C(F)(F)(F)(F)F)=N2)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(CN2C=C(C(F)(F)F)C(C#C(F)(F)(F)(F)F)=N2)=C1 PRXXPQIHAADQGI-UHFFFAOYSA-N 0.000 description 1
- VBGUJZXHEKUXNY-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(CN2C=C(Cl)C(C(F)(F)F)=N2)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(CN2C=C(Cl)C(C(F)(F)F)=N2)=C1 VBGUJZXHEKUXNY-UHFFFAOYSA-N 0.000 description 1
- YKJFUHPKEQVDKT-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(CN2C=C(I)C(C#C(F)(F)(F)(F)F)=N2)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(CN2C=C(I)C(C#C(F)(F)(F)(F)F)=N2)=C1 YKJFUHPKEQVDKT-UHFFFAOYSA-N 0.000 description 1
- ZDHNAFKDBRFZBC-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(CN2C=C(I)C=C2C(=O)C(F)(F)F)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(CN2C=C(I)C=C2C(=O)C(F)(F)F)=C1 ZDHNAFKDBRFZBC-UHFFFAOYSA-N 0.000 description 1
- QKWQUCLWWCQBPU-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(CN2C=CC(C#C(F)(F)(F)(F)F)=N2)=C1.CC1=C([N+](=O)[O-])C=CC(CN2N=CC=C2C#C(F)(F)(F)(F)F)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(CN2C=CC(C#C(F)(F)(F)(F)F)=N2)=C1.CC1=C([N+](=O)[O-])C=CC(CN2N=CC=C2C#C(F)(F)(F)(F)F)=C1 QKWQUCLWWCQBPU-UHFFFAOYSA-N 0.000 description 1
- ZWZFEWJGVPNJAR-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(CN2C=CC=C2C(=O)C(F)(F)F)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(CN2C=CC=C2C(=O)C(F)(F)F)=C1 ZWZFEWJGVPNJAR-UHFFFAOYSA-N 0.000 description 1
- YLFQGJZWKOYZCR-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(N2C=C(C#C(F)(F)(F)(F)F)C=N2)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(N2C=C(C#C(F)(F)(F)(F)F)C=N2)=C1 YLFQGJZWKOYZCR-UHFFFAOYSA-N 0.000 description 1
- QRFOSYWJUHUESE-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(N2C=C(I)C=N2)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(N2C=C(I)C=N2)=C1 QRFOSYWJUHUESE-UHFFFAOYSA-N 0.000 description 1
- SVWCFWUKNWSJLT-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(N2N=C(C(F)(F)C(F)(F)F)C=C2C(F)(F)F)=C1.CC1=C([N+](=O)[O-])C=CC(N2N=C(C(F)(F)C(F)(F)F)CC2(O)C(F)(F)F)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(N2N=C(C(F)(F)C(F)(F)F)C=C2C(F)(F)F)=C1.CC1=C([N+](=O)[O-])C=CC(N2N=C(C(F)(F)C(F)(F)F)CC2(O)C(F)(F)F)=C1 SVWCFWUKNWSJLT-UHFFFAOYSA-N 0.000 description 1
- HDKFQLJBZOFZNB-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(N2N=C(C(F)(F)F)C=C2C(F)(F)F)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(N2N=C(C(F)(F)F)C=C2C(F)(F)F)=C1 HDKFQLJBZOFZNB-UHFFFAOYSA-N 0.000 description 1
- AMWYUXMVIRBQTN-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(OC2=NC(C(F)(F)F)=CC(C(F)(F)F)=N2)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(OC2=NC(C(F)(F)F)=CC(C(F)(F)F)=N2)=C1 AMWYUXMVIRBQTN-UHFFFAOYSA-N 0.000 description 1
- CWBZJOQLXJQJHU-UHFFFAOYSA-N CC1=C([N+](=O)[O-])C=CC(SC2=NN=C(C#C(F)(F)(F)(F)F)N2C)=C1 Chemical compound CC1=C([N+](=O)[O-])C=CC(SC2=NN=C(C#C(F)(F)(F)(F)F)N2C)=C1 CWBZJOQLXJQJHU-UHFFFAOYSA-N 0.000 description 1
- YGWKFWYNVAZTJR-UHFFFAOYSA-N CC1=CC(C(C)N2C=CC(C(F)(F)F)=N2)=CC=C1N.CSCC(C)(C)NC(=O)C1=C(I)C=CC=C1C(=O)NC1=CC=C(C(C)N2C=CC(C(F)(F)F)=N2)C=C1C.CSCC(C)(C)NC(=O)C1=C(I)C=CC=C1C(=O)O Chemical compound CC1=CC(C(C)N2C=CC(C(F)(F)F)=N2)=CC=C1N.CSCC(C)(C)NC(=O)C1=C(I)C=CC=C1C(=O)NC1=CC=C(C(C)N2C=CC(C(F)(F)F)=N2)C=C1C.CSCC(C)(C)NC(=O)C1=C(I)C=CC=C1C(=O)O YGWKFWYNVAZTJR-UHFFFAOYSA-N 0.000 description 1
- ZDJFGRWPHCVSNG-UHFFFAOYSA-N CC1=CC(CC(=N)SCC(=O)C#C(F)(F)(F)(F)F)=CC=C1[N+](=O)[O-] Chemical compound CC1=CC(CC(=N)SCC(=O)C#C(F)(F)(F)(F)F)=CC=C1[N+](=O)[O-] ZDJFGRWPHCVSNG-UHFFFAOYSA-N 0.000 description 1
- PNBBDUQCTHUGPS-UHFFFAOYSA-N CC1=CC(CC(N)=S)=CC=C1[N+](=O)[O-] Chemical compound CC1=CC(CC(N)=S)=CC=C1[N+](=O)[O-] PNBBDUQCTHUGPS-UHFFFAOYSA-N 0.000 description 1
- NWHREIJQEFKKOU-UHFFFAOYSA-N CC1=CC(CC2=NC(C#C(F)(F)(F)(F)F)=CS2)=CC=C1[N+](=O)[O-] Chemical compound CC1=CC(CC2=NC(C#C(F)(F)(F)(F)F)=CS2)=CC=C1[N+](=O)[O-] NWHREIJQEFKKOU-UHFFFAOYSA-N 0.000 description 1
- MAKXSVOLKJYTIS-UHFFFAOYSA-N CC1=CC(CN2C(=O)N(C)N=C2C(F)F)=CC=C1[N+](=O)[O-] Chemical compound CC1=CC(CN2C(=O)N(C)N=C2C(F)F)=CC=C1[N+](=O)[O-] MAKXSVOLKJYTIS-UHFFFAOYSA-N 0.000 description 1
- IWTKJZCKYMYZIH-UHFFFAOYSA-N CC1=CC(CN2C=C(C#C(F)(F)(F)(F)F)C(C(F)(F)F)=N2)=CC=C1[N+](=O)[O-] Chemical compound CC1=CC(CN2C=C(C#C(F)(F)(F)(F)F)C(C(F)(F)F)=N2)=CC=C1[N+](=O)[O-] IWTKJZCKYMYZIH-UHFFFAOYSA-N 0.000 description 1
- APHVFSXFOXEMBF-UHFFFAOYSA-N CC1=CC(CN2C=C(I)C(C(F)(F)F)=N2)=CC=C1[N+](=O)[O-] Chemical compound CC1=CC(CN2C=C(I)C(C(F)(F)F)=N2)=CC=C1[N+](=O)[O-] APHVFSXFOXEMBF-UHFFFAOYSA-N 0.000 description 1
- OXSWKKJQPURAOF-DHCDNLJLSA-N CC1=CC(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)=CC=C1N.CSCC(C)(C)/N=C1\OC(=O)C2=CC=CC(C)=C21.CSCC(C)(C)NC(=O)C1=C(C)C=CC=C1C(=O)NC1=CC=C(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)C=C1C Chemical compound CC1=CC(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)=CC=C1N.CSCC(C)(C)/N=C1\OC(=O)C2=CC=CC(C)=C21.CSCC(C)(C)NC(=O)C1=C(C)C=CC=C1C(=O)NC1=CC=C(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)C=C1C OXSWKKJQPURAOF-DHCDNLJLSA-N 0.000 description 1
- RIUDGWVCTWTDNU-UHFFFAOYSA-N CC1=CC(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)=CC=C1N1C(=O)C2=CC=CC(F)=C2C1=O Chemical compound CC1=CC(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)=CC=C1N1C(=O)C2=CC=CC(F)=C2C1=O RIUDGWVCTWTDNU-UHFFFAOYSA-N 0.000 description 1
- ALAGACREEFUMTC-KZUQTAPCSA-N CC1=CC(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)=CC=C1N1C(=O)C2=CC=CC(F)=C2C1=O.CSC[C@H](C)N.CSC[C@H](C)NC(=O)C1=C(F)C=CC=C1C(=O)NC1=CC=C(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)C=C1C Chemical compound CC1=CC(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)=CC=C1N1C(=O)C2=CC=CC(F)=C2C1=O.CSC[C@H](C)N.CSC[C@H](C)NC(=O)C1=C(F)C=CC=C1C(=O)NC1=CC=C(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)C=C1C ALAGACREEFUMTC-KZUQTAPCSA-N 0.000 description 1
- OAYTVLCBAZVMHQ-UHFFFAOYSA-N CC1=CC(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)=CC=C1NC(=O)C1=CC=CC(I)=C1C(=O)NC(C)(C)CS(C)(=O)=O Chemical compound CC1=CC(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)=CC=C1NC(=O)C1=CC=CC(I)=C1C(=O)NC(C)(C)CS(C)(=O)=O OAYTVLCBAZVMHQ-UHFFFAOYSA-N 0.000 description 1
- AIMMYHZYNWFYKL-UHFFFAOYSA-N CC1=CC(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)=CC=C1NC(=O)C1=CC=CC(I)=C1C(=O)NC(C)(C)CS(C)=O Chemical compound CC1=CC(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)=CC=C1NC(=O)C1=CC=CC(I)=C1C(=O)NC(C)(C)CS(C)=O AIMMYHZYNWFYKL-UHFFFAOYSA-N 0.000 description 1
- GTZLXMTUJCVVCD-UHFFFAOYSA-N CC1=CC(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)=CC=C1NC(=O)C1=CC=CC(I)=C1C(=O)NC(C)CS(C)(=O)=O.CSCC(C)NC(=O)C1=C(I)C=CC=C1C(=O)NC1=CC=C(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)C=C1C Chemical compound CC1=CC(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)=CC=C1NC(=O)C1=CC=CC(I)=C1C(=O)NC(C)CS(C)(=O)=O.CSCC(C)NC(=O)C1=C(I)C=CC=C1C(=O)NC1=CC=C(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)C=C1C GTZLXMTUJCVVCD-UHFFFAOYSA-N 0.000 description 1
- AGCIJSWSBUOPTL-UHFFFAOYSA-N CC1=CC(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)=CC=C1NC(=O)C1=CC=CC(I)=C1C(=O)O.CSCC(C)N.CSCC(C)NC(=O)C1=C(I)C=CC=C1C(=O)NC1=CC=C(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)C=C1C Chemical compound CC1=CC(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)=CC=C1NC(=O)C1=CC=CC(I)=C1C(=O)O.CSCC(C)N.CSCC(C)NC(=O)C1=C(I)C=CC=C1C(=O)NC1=CC=C(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)C=C1C AGCIJSWSBUOPTL-UHFFFAOYSA-N 0.000 description 1
- ALVTXSZIJKUBOM-UHFFFAOYSA-N CC1=CC(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)=CC=C1[N+](=O)[O-] Chemical compound CC1=CC(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)=CC=C1[N+](=O)[O-] ALVTXSZIJKUBOM-UHFFFAOYSA-N 0.000 description 1
- QXUQACOUQYQWNB-SSVHSGQRSA-N CC1=CC(CN2N=C(C(F)(F)F)N=C2C(F)(F)F)=CC=C1/N=C1\OC(=O)C2=C(I)C=CC=C21.CSCC(C)N.CSCC(C)NC(=O)C1=C(I)C=CC=C1C(=O)NC1=CC=C(CN2N=C(C(F)(F)F)N=C2C(F)(F)F)C=C1C Chemical compound CC1=CC(CN2N=C(C(F)(F)F)N=C2C(F)(F)F)=CC=C1/N=C1\OC(=O)C2=C(I)C=CC=C21.CSCC(C)N.CSCC(C)NC(=O)C1=C(I)C=CC=C1C(=O)NC1=CC=C(CN2N=C(C(F)(F)F)N=C2C(F)(F)F)C=C1C QXUQACOUQYQWNB-SSVHSGQRSA-N 0.000 description 1
- IQOKFEBMDFTCIL-UHFFFAOYSA-N CC1=CC(CN2N=C(C)N=C2C(F)(F)F)=CC=C1N Chemical compound CC1=CC(CN2N=C(C)N=C2C(F)(F)F)=CC=C1N IQOKFEBMDFTCIL-UHFFFAOYSA-N 0.000 description 1
- NBUJOAYUYFAVGQ-UHFFFAOYSA-N CC1=CC(CN2N=C(C)N=C2C(F)(F)F)=CC=C1[N+](=O)[O-] Chemical compound CC1=CC(CN2N=C(C)N=C2C(F)(F)F)=CC=C1[N+](=O)[O-] NBUJOAYUYFAVGQ-UHFFFAOYSA-N 0.000 description 1
- NGNLEUNUPVGTAL-UHFFFAOYSA-N CC1=CNN=C1C#C(F)(F)(F)(F)F Chemical compound CC1=CNN=C1C#C(F)(F)(F)(F)F NGNLEUNUPVGTAL-UHFFFAOYSA-N 0.000 description 1
- ZWXAVIBKKKTERN-UHFFFAOYSA-N CC1=NNC(C(F)(F)F)=N1 Chemical compound CC1=NNC(C(F)(F)F)=N1 ZWXAVIBKKKTERN-UHFFFAOYSA-N 0.000 description 1
- SBTYRPHKAJIGAZ-UHFFFAOYSA-N CCOC(=O)C(CC1=CC(C)=C([N+](=O)[O-])C=C1)C(=O)C(F)(F)F Chemical compound CCOC(=O)C(CC1=CC(C)=C([N+](=O)[O-])C=C1)C(=O)C(F)(F)F SBTYRPHKAJIGAZ-UHFFFAOYSA-N 0.000 description 1
- PVACLCXVHHQQAF-UHFFFAOYSA-N CCOC(=O)CC(=O)C1=CC(C)=C([N+](=O)[O-])C=C1 Chemical compound CCOC(=O)CC(=O)C1=CC(C)=C([N+](=O)[O-])C=C1 PVACLCXVHHQQAF-UHFFFAOYSA-N 0.000 description 1
- ITXHKSGGFZMURM-UHFFFAOYSA-N CS(=O)(=O)C1=NC(C(F)(F)F)=CC(C(F)(F)F)=N1 Chemical compound CS(=O)(=O)C1=NC(C(F)(F)F)=CC(C(F)(F)F)=N1 ITXHKSGGFZMURM-UHFFFAOYSA-N 0.000 description 1
- UOOOMONDHDNWDU-UHFFFAOYSA-N CSCC(C)(C)NC(=O)C1=C(I)C=CC=C1C(=O)NC1=CC=C(C(C)N2C=CC(C(F)(F)F)=N2)C=C1C Chemical compound CSCC(C)(C)NC(=O)C1=C(I)C=CC=C1C(=O)NC1=CC=C(C(C)N2C=CC(C(F)(F)F)=N2)C=C1C UOOOMONDHDNWDU-UHFFFAOYSA-N 0.000 description 1
- IRQAHZSZYUMIMM-UHFFFAOYSA-N CSCC(C)(C)NC(=O)C1=C(I)C=CC=C1C(=O)NC1=CC=C(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)C=C1C Chemical compound CSCC(C)(C)NC(=O)C1=C(I)C=CC=C1C(=O)NC1=CC=C(CN2N=C(C(F)(F)F)C=C2C(F)(F)F)C=C1C IRQAHZSZYUMIMM-UHFFFAOYSA-N 0.000 description 1
- ZYMTYZHEDMAECG-UHFFFAOYSA-N FC(F)(F)C1=NC(C#C(F)(F)(F)(F)F)=NN1 Chemical compound FC(F)(F)C1=NC(C#C(F)(F)(F)(F)F)=NN1 ZYMTYZHEDMAECG-UHFFFAOYSA-N 0.000 description 1
- JTHNMRUVJDWVMJ-UHFFFAOYSA-N FC(F)(F)C1=NNC=C1Br Chemical compound FC(F)(F)C1=NNC=C1Br JTHNMRUVJDWVMJ-UHFFFAOYSA-N 0.000 description 1
- YTLDTZLZQMKURR-UHFFFAOYSA-N FC(F)(F)C1=NNC=C1Cl Chemical compound FC(F)(F)C1=NNC=C1Cl YTLDTZLZQMKURR-UHFFFAOYSA-N 0.000 description 1
- XRUHSOXIZMYOHX-UHFFFAOYSA-N FC(F)(F)C1=NNC=C1I Chemical compound FC(F)(F)C1=NNC=C1I XRUHSOXIZMYOHX-UHFFFAOYSA-N 0.000 description 1
- JEKSOBJWQFIIKT-UHFFFAOYSA-N FC(F)C(F)(F)C1=CNN=C1C#C(F)(F)(F)(F)F Chemical compound FC(F)C(F)(F)C1=CNN=C1C#C(F)(F)(F)(F)F JEKSOBJWQFIIKT-UHFFFAOYSA-N 0.000 description 1
- GSKWQBCWXLKCRZ-UHFFFAOYSA-N O=C(C1=CC(I)=CN1)C(F)(F)F Chemical compound O=C(C1=CC(I)=CN1)C(F)(F)F GSKWQBCWXLKCRZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/16—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
Definitions
- the present invention relates to novel benzenedicarboxamides, processes for the preparation thereof, their intermediates and their use as insecticides.
- the benzenedicarboxamides of the formula (I) show a strong insecticidal action.
- Halogen represents fluorine, chlorine, bromine and iodine, and preferably represents fluorine, chlorine and bromine.
- Alkyl represents straight chain or branched chain C 1-12 alkyl, for example, methyl, ethyl, n- or iso-propyl, n-, iso-, sec- or tert-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, n-nonyl, n-decyl, n-undecyl, n-dodecyl, etc. and preferably represents C 1-6 alkyl.
- alkylsulfonyloxy As each alkyl part in “alkylsulfonyloxy”, “alkylsulfenyl”, “alkylthioalkyl”, “alkylsulfinylalkyl”, “alkylsulfonylalkyl”, “alkoxy”, “alkylthio”, “alkylsulfinyl”, “alkylsulfonyl”, “haloalkyl”, “haloalkoxy”, “haloalkylthio”, “haloalkylsulfinyl”, “haloalkylsulfonyl” and “haloalkylcarbonyl”, there can be mentioned the same as described in the above-mentioned “alkyl” as examples.
- haloalkyl As each halogen part in “haloalkyl”, “haloalkoxy”, “haloalkylthio”, “haloalkylsulfinyl”, “haloalkylsulfonyl” and “haloalkylcarbonyl”, there can be mentioned the same as described in the above-mentioned “halogen” as examples.
- “5- or 6-membered heterocyclic group” contains at least one hetero atom selected from the group consisting of N, O and S, and preferably represents a heterocyclic group containing “one to three N atoms”, or “one O atom”, or “one S atom”, or “both one S atom and one to two N atoms”, or “both one O atom and one to two N atoms”, and as specific examples thereof, pyrazolyl, triazolyl, pyrazolinyl, imidazolyl, thiazolyl, pyrrolyl, furyl, thienyl, oxadiazolyl and pyrimidinyl, and moreover as most preferable examples thereof, pyrazolyl, triazolyl, pyrazolinyl, imidazolyl, thiazolyl, pyrrolyl, oxadiazolyl and pyrimidinyl are exemplified.
- the compounds of the formula (I), according to the present invention include stereo isomers (R/S configuration) in case that the group R 1 has an asymmetric carbon.
- the aforementioned process (a) can be illustrated by the following reaction scheme in case that, for example, 3-(1,1-dimethyl-2-methylthioethylimino)-4-iodo-3H-isobenzofuran-1-one and 1-(4-amino-3-methylbenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole are used as starting materials.
- the aforementioned preparation process (b) can be illustrated by the following reaction scheme in case that, for example, 2- ⁇ 4-[3,5-bis(trifluoromethyl)pyrazole-1-ylmethyl]-2-methylphenyl ⁇ -4-fluoroisoindole-1,3-dione and (S)-1-methyl-2-methylthioethylamine are used as starting materials.
- the aforementioned preparation process (c) can be illustrated by the following reaction scheme in case that, for example, 3-iodo-N-(1,1-dimethyl-2-methylthioethyl)-phthalamic acid and 2-methyl-4-[1-(3-trifluoromethylpyrazole-1-yl)-ethyl]aniline are used as starting materials.
- the aforementioned preparation process (d) can be illustrated by the following reaction scheme in case that, for example, 1-[4-(4-iodo-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methyl-benzyl]-3,5-bis(trifluoromethyl)-(1,2,4)-triazol and 1-methyl-2-methylthioethylamine are used as starting materials.
- the aforementioned preparation process (e) can be illustrated by the following reaction scheme in case that, for example, N- ⁇ 4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-2-methyl-phenyl ⁇ -6-iodo-phthalamic acid and 1-methyl-2-methylthioethylamine are used as starting materials.
- the aforementioned process (f) can be illustrated by the following reaction scheme in case that, for example, N 2 -(1-methyl-2-methylthioethyl)-3-iodo-N 1 - ⁇ 2-methyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]phenyl ⁇ phthalamide and m-chloroperbenzoic acid are used as starting materials.
- the compounds of the formula (II), used as starting materials in the above-mentioned preparation process (a), are per se known compounds and can be easily prepared according to the process described in, for example, JP-A 11-240857 (1999), JP-A 2001-131141.
- Y, A, m and Q have the same definitions as aforementioned, according to the catalytic hydrogen reduction process, a well-known process in the field of organic chemistry, with hydrogen in the presence of a catalytic reduction catalyst, for example, palladium carbon, Raney nickel, platinum oxide, etc.
- a catalytic reduction catalyst for example, palladium carbon, Raney nickel, platinum oxide, etc.
- the above-mentioned catalytic hydrogen reduction process can be conducted in an adequate diluent.
- ethers for example, ethyl ether, methyl ethyl ether, isopropyl ether, butyl ether, dioxane, tetrahydrofuran (THF), etc.
- alcohols for example, methanol, ethanol, isopropanol, butanol, ethylene glycol, etc.
- catalytic reduction catalyst there can be mentioned, palladium carbon, Raney nickel, platinum oxide, etc.
- the reaction can be conducted at the temperatures generally from about 0 to about 100° C., preferably from room temperature (20° C.) to about 80° C.
- Said reaction can be conducted usually under normal pressure but can be operated optionally also under elevated pressure.
- a compound of the formula (III) can be obtained by hydrogenating the compounds of the formula (IX) in a diluent, for example, ethanol, in the presence of 0.1-10% (w/w) palladium carbon.
- a diluent for example, ethanol
- the compounds of the formula (III) can be obtained from the compounds of the formula (IX).
- the compounds of the formula (IX) are novel compounds and can be obtained by reacting the compounds of the formula (IX) wherein A represents other than oxygen atom, for example, compounds of the formula (X)
- nitro-substituted benzoic acids and their esters, starting materials of the compounds of the formula (X), are known compounds described in, for example, Chem. Ber., Vol. 52 (1919), p. 1083; Bull. Soc. Chim. Fr. (1962), p. 2255-2261; Tetrahedron (1985), p. 115-118; Chem. Pharm. Bull., Vol. 41 (1993), p. 894-906; WO 2001/042227.
- the compounds of the formula (XI) include known compounds and as their specific examples, there can be mentioned:
- aliphatic, alicyclic and aromatic hydrocarbons may be optionally chlorinated
- ethers for example, ethyl ether, methyl ethyl ether, isopropyl ether, butyl ether, dioxane, dimethoxyethane (DME), tetrahydrofuran (THF), diethylene glycol dimethyl ether (DGM), etc.
- ketones for example, acetone, methyl ethyl ketone (MEK), methyl isopropyl ketone, methyl isobutyl ketone (MIBK), etc.
- nitriles for example, acetonitrile, propion
- the reaction can be conducted in the presence of an acid binder and as said acid binder there can be mentioned, for example, as inorganic base, hydrides, hydroxides, carbonates, bicarbonates, etc. of alkali metals or alkaline earth metals, for example, sodium hydride, lithium hydride, sodium hydrogen carbonate, potassium hydrogen carbonate, sodium carbonate, potassium carbonate, lithium hydroxide, sodium hydroxide, potassium hydroxide, calcium hydroxide, etc.; inorganic alkali metal amides, for example, lithium amide, sodium amide, potassium amide, etc.; as organic base, alcoholates, tertiary amines, dialkylaminoanilines and pyridines, for example, triethylamine, 1,1,4,4-tetramethylethylenediamine (TMEDA), N,N-dimethylaniline, N,N-diethylaniline, pyridine, 4-dimethylaminopyridine (DMAP), 1,4-diazabicyclo[2,2,
- the above-mentioned reaction can also be conducted by a process using a phase transfer catalyst in the presence of a diluent.
- a diluent used in that case there can be mentioned water; aliphatic, alicyclic and aromatic hydrocarbons (may be optionally chlorinated), for example, pentane, hexane, cyclohexane, petroleum ether, ligroine, benzene, toluene, xylene, etc.; ethers, for example, ethyl ether, methyl ethyl ether, isopropyl ether, butyl ether, dioxane, dimethoxyethane (DME), tetrahydrofuran diethylene glycol dimethyl ether (DGM), etc.
- DME dimethoxyethane
- DGM tetrahydrofuran diethylene glycol dimethyl ether
- phase transfer catalyst examples include quaternary ions, for example, tetramethylammonium bromide, tetrapropylammonium bromide, tetrabutylammonium bromide, tetrabutylammonium bissulfate, tetrabutylammonium iodide, trioctylmethylammonium chloride, benzyltriethylammonium bromide, butylpyridinium bromide, heptylpyridinium bromide, benzyltriethylammonium chloride, etc.; crown ethers, for example, dibenzo-18-crown-6, dicyclohexyl-18-crown-6, 18-crown-6, etc.; cryptands, for example, [2.2.2]-cryptate, [2.1.1]-cryptate, [2.2.1]-cryptate, [2.2.B]-cryptate, [3.2.2]-cryptate, etc.
- the above-mentioned reaction can be conducted in a substantially wide range of temperature. It is adequate to conduct it at the temperatures in a range of generally from about 0 to about 200° C., preferably from room temperature (20° C.) to about 150° C.
- reaction is conducted desirably under normal pressure, it can be operated also under elevated pressure or under reduced pressure.
- the aimed compounds of the formula (IX) can be obtained, for example, by reacting 1 mole to a little excess mole amount of the compounds of the formula (XI) to 1 mole of the compounds of the formula (X) in a diluent, for example, DMF, in the presence of potassium carbonate.
- a diluent for example, DMF
- 2-(3-methyl-4-nitrobenzyl)-4-pentafluoroethyl-thiazole can be prepared by the following way in which a known compound, 3-methyl-4-niirobenzylcyanide (see J. Chem. Soc., vol. 97 (1910), p. 2260) is reacted with hydrogen sulfide, and then the product, 3-methyl-4-nitro-benzylthioamide is reacted with a commercial product, 1-bromo-3,3,4,4,4-pentafluoro-2-butanone and then cyclized, according to a method described in J. Heterocycl. Chem., vol. 28 (1991) p. 907 to 911.
- 2-(3-methyl-4-nitrobenzyl)-5-trifluoromethyl-1,3,4-oxazole can easily be obtained, according to a method described in Heterocycles, (1994) vol. 38, p. 981 to 990, from the corresponding 3-methyl-4-nitrobenzaldehyde oxime.
- the oxime can be obtained from a known 3-methyl-4-nitrobenzaldehyde [see J. Chem. Soc. B, (1967) p. 1154 to 1158] as a starting material, according to methods described in J. Chem. Soc. C, (1969) p. 986 to 990 and then Tetrahedron Letter, vol. 35 (1994) p. 9099 to 9100.
- 3-(3-methyl-4-nitrophenyl)-5-trifluoromethyl-1,2,4-oxazole can easily be obtained from 3-methyl-4-nitrobenzamideoxime, according to a method described in 3. Org. Chem., vol. 68(2), 2003, p. 605-608.
- 3-methyl-4-nitrobenzamideoxime can be prepared by a reaction of a commercial 3-methyl-4-nitrobenzonitrile with hydroxylamine, according to a method described in Chem. Ber., vol. 22 (1889), p. 2428.
- 3-(3-methyl-4-nitrobenzyl)-5-trifluoromethyl-1,2,4-oxazole can easily be obtained from 2-(3-methyl-4-nitrophenyl)-acetamideoxime as well, according to a method described in J. Org. Chem., vol. 68(2), 2003, p. 605-608.
- 2-(3-methyl-4-nitrophenyl)-acetamideoxime can be prepared by a reaction of 3-methyl-4-nitrophenyl-acetonitrile with hydroxylamine, according to a method described in Chem. Ber., vol. 22 (1889), p. 2428.
- the compounds of the formula (IX) can be prepared, besides the above-mentioned preparation process, also by the process to be mentioned later in Examples as an alternative.
- the compounds of the formula (IV), used as starting materials in the above-mentioned preparation process (b), are novel compounds and can be easily obtained according to the process described in Japanese Laid-open Patent Publication No. 61-246161 (1986), for example, by reacting compounds of the formula (XD)
- the reaction can be conducted in an adequate diluent.
- a diluent for example, aliphatic, alicyclic and aromatic hydrocarbons (may be optionally chlorinated), for example, pentane, hexane, cyclohexane, petroleum ether, ligroin, benzene, toluene, xylene, dichloromethane, chloroform, carbon tetrachloride, 1,2-dichloroethane, chlorobenzene, dichlorobenzene, etc.; ethers, for example, ethyl ether, methyl ethyl ether, isopropyl ether, butyl ether, dioxane, dimethoxyethane (DME), tetrahydrofuran (THF), diethylene glycol dimethyl ether (DGM), etc.; esters, for example, ethyl acetate, amyl acetate, etc
- the reaction can be conducted in a substantially wide range of temperature. It is adequate to conduct it at the temperatures in a range of generally from room temperature (20° C.) to about 200° C., preferably from room temperature to 150° C.
- reaction is conducted desirably under normal pressure, it can be operated also under elevated pressure or under reduced pressure.
- the aimed compounds of the formula (IV) can be obtained, for example, by reacting equimolar to a little excess mole amount of the compounds of the formula (II) to 1 mole of the compounds of the formula (XII) in a diluent, for example, acetic acid.
- 3-methanesulfonyloxyphthalic anhydride can be easily obtained from 3-hydroxyphthalic anhydride and methanesulfonyl chloride according to the process described in Tetrahedron Letters Vol. 29, p. 5595-8 (1988).
- the compounds of the formula (V), used as starting materials in the preparation process (b), are either compounds well known in the field of organic chemistry or can be synthesized according to the process described in DE-A 20 45 905, WO 01/23350.
- ethylamine diethylamine, n-propylamine, isopropylamine, n-butylamine, sec-butylamine, isobutylamine, t-butylamine, t-amylamine, 2-(methylthio)-ethylamine, 2-(ethylthio)-ethylamine, 1-methyl-2-(methylthio)-ethylamine, 1,1-dimethyl-2-(methylthio)-ethylamine and so on.
- the compounds of the formula (VI), used as starting materials in the preparation process (c), include publicly known compounds and can be easily prepared according to the process described in JP-A 11-240857 (1999), JPA 2001-131141, etc.
- R 1 has the same definitions as aforementioned
- the compounds of the above-mentioned formula (XIII) are well known in the field of organic chemistry and there can be specifically mentioned, for example, ethylamine, n-propylamine, isopropylamine, n-butylamine, sec-butylamine, isobutylamine, t-butylamine, t-amylamine, 2-(methylthio)ethylamine, 2-(ethylthio)ethylamine, 1-methyl-2-(methylthio)ethylamine, 1,1-dimethyl-2-(methylthio)ethylamine, etc.
- Said reaction can be conducted in an adequate diluent, and as examples of the diluent used in that case there can be mentioned aliphatic, alicyclic and aromatic hydrocarbons (may be optionally chlorinated), for example, pentane, hexane, cyclohexane, petroleum ether, ligroine, benzene, toluene, xylene, dichloromethane, chloroform, carbon tetrachloride, 1,2-dichloroethane, chlorobenzene, dichlorobenzene, etc.; ethers, for example, ethyl ether, methyl ethyl ether, isopropyl ether, butyl ether, dioxane, dimethoxyethane (DME), tetrahydrofuran (TIM, diethylene glycol dimethyl ether (DGM), etc.; ketones, for example, acetone, methyl ethyl ketone (MEK
- the above-mentioned reaction can be conducted in the presence of a base, and as said base there can be mentioned, for example, tertiary amines, dialkylaminoanilines and pyridines, for example, triethylamine, 1,1,4,4-tetramethylethylenediamine (TMEDA), N,N-dimethylaniline, N,N-diethylaniline, pyridine, 4-dimethylaminopyridine (DMAP), 1,4-diazabicyclo[2,2,2]octane (DABCO), 1,8-diazabicyclo[5,4,0]undec-7-ene (DBU), etc.
- a base for example, tertiary amines, dialkylaminoanilines and pyridines, for example, triethylamine, 1,1,4,4-tetramethylethylenediamine (TMEDA), N,N-dimethylaniline, N,N-diethylaniline, pyridine, 4-
- the above-mentioned reaction can be conducted in a substantially wide range of temperature. It is adequate to conduct it at the temperatures in a range of generally from about ⁇ 70 to about 100° C., preferably from about ⁇ 50 to about 80° C.
- reaction is conducted desirably under normal pressure, it can be operated also under elevated pressure or under reduced pressure.
- the aimed compounds of the formula (VI) can be obtained, for example, by reacting 1-4 moles of the compounds of the formula (XIII) to 1 mole of the compounds of the formula (XII) in a diluent, for example, acetonitrile.
- the compounds of the formula (VII), used as starting materials in the preparation process (d), are novel compounds and can be easily obtained, for example, by reacting the compounds of the formula (VIII), starting materials in the below-mentioned preparation process (e), according to the process described in J. Med. Chem., Vol. 10, p. 982 (1967) etc. in the presence of a condensing agent.
- the compounds of the formula (VIII), used as starting materials in the preparation process (e), are novel compounds and can be easily obtained, for example, by reacting phthalic anhydrides of the aforementioned formula (XII) with the compounds of the aforementioned formula (III).
- aliphatic, alicyclic and aromatic hydrocarbons may be optionally chlorinated
- ethers for example, ethyl ether, methyl ethyl ether, isopropyl ether, butyl ether, dioxane, dimethoxyethane (DME), tetrahydrofuran (THF), diethylene glycol dimethyl ether (DGM), etc.
- ketones for example, acetone, methyl ethyl
- the above-mentioned reaction can be conducted in the presence of a base, and as said base there can be mentioned tertiary amines, dialkylaminoanilines and pyridines, for example, triethylamine, 1,1,4,4-tetramethylethylenediamine (TMEDA), N,N-dimethylaniline, N,N-diethylaniline, pyridine, 4-dimethylaminopyridine (DMAP), 1,4-diazabicyclo[2,2,2]octane (DABCO) and 1,8-diazabicyclo[5,4,0]undec-7-ene (DBU), etc.
- tertiary amines dialkylaminoanilines and pyridines
- TMEDA 1,1,4,4-tetramethylethylenediamine
- DMAP 1,4-diazabicyclo[2,2,2]octane
- DBU 1,8-diazabicyclo[5,4,0]undec-7-
- the above-mentioned reaction can be conducted in a substantially wide range of temperature. It is adequate to conduct it at the temperatures in a range of generally from about ⁇ 70 to about 100° C., preferably from about ⁇ 50 to about 80° C.
- reaction is conducted desirably under normal pressure, it can be operated also under elevated pressure or under reduced pressure.
- the compounds of the formula (V), similarly used as starting materials in the preparation process (e), can be the same as ones used in the aforementioned preparation processes (b) and (d).
- the compounds of the formula (If), used as starting materials in the preparation process (f), are compounds included in the formula (I) of the present invention.
- the compounds of the formula (I), in which the group R If corresponds to C 1-6 alkylsulfinyl-C 1-6 alkyl or C 1-6 alkylsulfonyl-C 1-6 alkyl can be obtained.
- the compounds of the formula (If) can be prepared by the processes of the aforementioned preparation processes (a), (b), (c), (d) and/or (e).
- the reaction of the aforementioned preparation process (a) can be conducted in an adequate diluent singly or mixed.
- the preparation process (a) can be conducted in the presence of an acid catalyst, and as examples of said acid catalyst there can be mentioned mineral acids, for example, hydrochloric acid and sulfuric acid; organic acids, for example, acetic acid, trifluoroacetic acid, propionic acid, methanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, etc.
- mineral acids for example, hydrochloric acid and sulfuric acid
- organic acids for example, acetic acid, trifluoroacetic acid, propionic acid, methanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, etc.
- the preparation process (a) can be conducted in a substantially wide range of temperature. It is adequate to conduct it at the temperatures in a range of generally from about ⁇ 20 to about 100° C., preferably from about 0 to about 100° C.
- reaction is conducted desirably under normal pressure, it can be operated also under elevated pressure or under reduced pressure.
- the aimed compounds of the formula (I) can be obtained, for example, by reacting 1 to a little excess mole amount of the compounds of the formula (III) to 1 mole of the compounds of the formula (II) in a diluent, for example, 1,2-dichloroethane in the presence of 0.01-0.1 mole amount of p-toluenesulfonic acid.
- a diluent for example, 1,2-dichloroethane in the presence of 0.01-0.1 mole amount of p-toluenesulfonic acid.
- the reaction of the aforementioned preparation process (b) can be conducted in an adequate diluent.
- aliphatic, alicyclic and aromatic hydrocarbons may be optionally chlorinated
- ethers for example, ethyl ether, methyl ethyl ether, isopropyl ether, butyl ether, dioxane, dimethoxyethane (DME), tetrahydrofuran (Tiff), diethylene glycol dimethyl ether (DGM), etc.
- esters for example, ethyl acetate,
- the preparation process (b) can be conducted in the presence of an acid catalyst and as examples of said acid catalyst there can be mentioned mineral acids, for example, hydrochloric acid and sulfuric acid; organic acids, for example, acetic acid, trifluoroacetic acid, propionic acid, methanesulfonic acid, p-toluenesulfonic acid, etc.
- mineral acids for example, hydrochloric acid and sulfuric acid
- organic acids for example, acetic acid, trifluoroacetic acid, propionic acid, methanesulfonic acid, p-toluenesulfonic acid, etc.
- the preparation process (b) can be conducted in a substantially wide range of temperature. It is adequate to conduct it at the temperatures in a range of generally from about ⁇ 20 to about 150° C., preferably from room temperature (20° C.) to about 100° C.
- reaction is conducted desirably under normal pressure, it can be operated also under elevated pressure or under reduced pressure.
- the aimed compounds of the formula (I) can be obtained, for example, by reacting 1-25 moles of the compounds of the formula (V) to 1 mole of the compounds of the formula (IV) in a diluent, for example, dioxane in the presence of 0.01-0.5 mole amount of acetic acid.
- a diluent for example, dioxane
- the reaction of the aforementioned preparation process (f) can be conducted in an adequate diluent.
- aliphatic, alicyclic and aromatic hydrocarbons may be optionally chlorinated
- aliphatic, alicyclic and aromatic hydrocarbons may be optionally chlorinated
- alcohols for example, methanol, ethanol, isopropanol and butanol
- acids formic acid, acetic acid, etc.
- oxidizing agents usable in the aforementioned preparation process (f) there can be mentioned, for example, m-chloroperbenzoic acid, peracetic acid, potassium metaperiodate, potassium hydrogen persulfate (oxon), hydrogen peroxide, etc.
- the preparation process (f) can be conducted in a substantially wide range of temperature. It is adequate to conduct it at the temperatures in a range of generally from about ⁇ 50 to about 150° C., preferably from about ⁇ 10 to about 100° C.
- reaction is conducted desirably under normal pressure, it can be operated also under elevated pressure or under reduced pressure.
- the aimed compounds of the corresponding formula (I) can be obtained, for example, by reacting 1-5 moles of an oxidizing agent to 1 mole of the compounds of the formula (If) in a diluent, for example, dichloromethane.
- reaction of the aforementioned preparation process (f) can be conducted, for example, according to the process described in JIKKEN KAGAKU KOZA (Lecture on experimental chemistry) edited by the Chemical Society of Japan, 4 th ed., Vol. 24, p. 350 (1992) published by MARUZEN or ibid. p. 365.
- the compounds of the formula (I) of the present invention show strong insecticidal action.
- the compounds of the formula (I), according to the present invention can, therefore, be used as insecticidal agents.
- the active compounds of the formula (I) of the present invention exhibit exact controlling effect against harmful insects without giving phytotoxicity on cultured plants.
- the compounds of the present invention can be used for controlling a wide variety of pests, for example, harmful sucking insects, biting insects and other plant-parasitic pests, stored grain pests, hygienic pests, etc. and applied for their extermination.
- Coleoptera pests for example, Callosobruchus Chinensis, Sitophilus zeamais, Tribolium castaneum, Epilachna vigintioctomaculata, Agriotes fuscicollis, Anomala rufocuprea, Leptinotarsa decemlineata, Diabrotica spp., Monochamus alternatus, Lissorhoptrus oryzophilus, Lyctus bruneus;
- Lepidoptera pests for example,
- Lymantria dispar Malacosoma neustria, Pieris rapae, Spodoptera litura, Mamestra brassicae, Chilo suppressalis, Pyrausta nubilalis, Ephestia cautella, Adoxophyes orana, Carpocapsa pomonella, Agrotis fucosa, Galleria mellonella, Plutella maculipennis, Heliothis virescens, Phyllocnistis citrella;
- Hemiptera pests for example,
- Nephotettix cincticeps Nephotettix cincticeps, Nilaparvata lugens, Pseudococcus comstocki, Unaspis yanonensis, Myzus persicae, Aphis pomi, Aphis gossypii, Rhopalosiphum pseudobrassicas, Stephanitis nashi, Nazara spp., Trialeurodes vaporariorum, Psylla spp.;
- Thysanoptera pests for example,
- Orthoptera pests for example,
- Homoptera pests for example,
- Diptera pests for example,
- Musca domestica Aedes aegypti, Hylemia platura, Culex pipiens, Anopheles slnensis, Culex tritaeniorlzynchus, Liriomyzae trifolii etc.
- Tetranychus cinnabarinus Tetranychus urticae, Panonychus citri, Aculops pelekassi, Tarsonemus spp., etc.
- nematodes there can be mentioned, for example,
- novel compounds of the present invention can be effectively used against various harmful animal-parasitic pests (endoparasites and ectoparasites), for example, insects and helminthes.
- animal-parasitic pests there can be mentioned the following pests:
- insects there can be mentioned, for example,
- Gastrophilus spp. Stomoxys spp., Trichodectes spp., Rhodnius spp., Ctenocephalides canis, Cimex lectularius etc.
- Ornithodoros spp. Ixodes spp., Boophilus spp., etc.
- insects substances having insecticidal action against pests, which include all of them, are in some cases called as insecticides.
- Plants are to be understood as meaning in the present context all plants and plant populations such as desired and undesired wild plants or crop plants (including naturally occurring crop plants).
- Crop plants can be plants which can be obtained by conventional plant breeding and optimization methods or by biotechnological and genetic engineering methods or by combinations of these methods, including the transgenic plants and including the plant cultivars protectable or not protectable by plant breeders' rights.
- Plant parts are to be understood as meaning all parts and organs of plants above and below the ground, such as shoot, leaf, flower and root, examples which may be mentioned being leaves, needles, stalks, stems, flowers, fruit bodies, fruits, seeds, roots, tubers and rhizomes.
- the plant parts also include harvested material, and vegetative and generative propagation material, for example cuttings, tubers, rhizomes, offshoots and seeds.
- Treatment according to the invention of the plants and plant parts with the active compounds is carried out directly or by allowing the compounds to act on the surroundings, environment or storage space by the customary treatment methods, for example by immersion, spraying, evaporation, fogging, scattering, painting on and, in the case of propagation material, in particular in the case of seeds, also by applying one or more coats.
- the active compounds can be converted into the customary formulation forms, when they are used as insecticides.
- formulation forms there can be mentioned, for example, solutions, emulsions, wettable powders, water dispersible granules, suspensions, powders, foams, pastes, tablets, granules, aerosols, natural and synthetic materials impregnated with active compound, microcapsules, seed coating agents, formulations used with burning equipment (as burning equipment, for example, fumigation and smoking cartridges, cans, coils, etc.), ULV [cold mist, warm mist], etc.
- formulations can be produced according to per se known methods, for example, by mixing the active compounds with extenders, namely liquid diluents or carriers; liquefied gas diluents or carriers; solid diluents or carriers, and optionally with surface-active agents, namely emulsifiers and/or dispersants and/or foam-forming agents.
- extenders namely liquid diluents or carriers; liquefied gas diluents or carriers; solid diluents or carriers, and optionally with surface-active agents, namely emulsifiers and/or dispersants and/or foam-forming agents.
- organic solvents can also be used as auxiliary solvents.
- liquid diluents or carriers there can be mentioned, for example, aromatic hydrocarbons (for example, xylene, toluene, alkylnaphthalene, etc.), chlorinated aromatic or chlorinated aliphatic hydrocarbons (for example, chlorobenzenes, ethylene chlorides, methylene chloride, etc.), aliphatic hydrocarbons [for example, cyclohexane etc.
- aromatic hydrocarbons for example, xylene, toluene, alkylnaphthalene, etc.
- chlorinated aromatic or chlorinated aliphatic hydrocarbons for example, chlorobenzenes, ethylene chlorides, methylene chloride, etc.
- aliphatic hydrocarbons for example, cyclohexane etc.
- paraffins for example, mineral oil fractions etc.
- alcohols for example, butanol, glycols and their ethers, esters, etc.
- ketones for example, acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone, etc.
- strongly polar solvents for example, dimethylformamide, dimethyl sulfoxide, etc.
- Liquefied gas diluents or carriers are substances that are gases at normal temperature and pressure and there can be mentioned, for example, aerosol propellants such as butane, propane, nitrogen gas, carbon dioxide, halogenated hydrocarbons.
- ground natural minerals for example, kaolin, clay, talc, chalk, quartz, attapulgite, montmorillonite, diatomaceous earth, etc.
- ground synthetic minerals for example, highly dispersed silicic acid, alumina, silicates, etc.
- solid carriers for granules there can be mentioned, for example, crushed and fractionated rocks (for example, calcite, marble, pumice, sepiolite, dolomite, etc.), synthetic granules of inorganic or organic meals, particles of organic materials (for example, saw dust, coconut shells, maize cobs, tobacco stalks, etc.), etc.
- crushed and fractionated rocks for example, calcite, marble, pumice, sepiolite, dolomite, etc.
- synthetic granules of inorganic or organic meals for example, saw dust, coconut shells, maize cobs, tobacco stalks, etc.
- nonionic and anionic emulsifiers for example, polyoxyethylene fatty acid esters, polyoxyethylene fatty acid alcohol ethers (for example, alkylaryl polyglycol ethers), alkylsulfonates, alkylsulfates, arylsulfonates, etc.], albumin hydrolysis products, etc.
- Dispersants include, for example, lignin sulfite waste liquor and methyl cellulose.
- Tackifiers can also be used in formulations (powders, granules, emulsifiable concentrates).
- tackifiers there can be mentioned, for example, carboxymethyl cellulose, natural or synthetic polymers (for example, gum Arabic, polyvinyl alcohol, polyvinyl acetate, etc.).
- Colorants can also be used.
- inorganic pigments for example, iron oxide, titanium oxide, Prussian Blue, etc.
- organic dyestuffs such as alizarin dyestuffs, azo dyestuffs or metal phthalocyanine dyestuffs
- further trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.
- Said formulations can contain the aforementioned active component of the amount in the range of generally 0.1-95% by weight, preferably 0.5-90% by weight.
- the active compounds of the formula (I) of the present invention can exist also as a mixed agent with other active compounds, for example, insecticides, poisonous baits, bactericides, miticides, nematicides, fungicides, growth regulators or herbicides in the form of their commercially useful formulations and in the application forms prepared from such formulations.
- insecticides for example, organophosphorous agents, carbamate agents, carboxylate type chemicals, chlorinated hydrocarbon type chemicals, insecticidal substances produced by microorganisms, etc.
- the active compounds of the formula (I) of the present invention can exist also as a mixed agent with a synergist, and such formulations and application forms can be mentioned as commercially useful. Said synergist itself must not be active, but is a compound that enhances the action of the active compound.
- bronopol dichlorophen, nitrapyrin, nickel dimethyldithiocarbamate, kasugamycin, octhilinone, furancarboxylic acid, oxytetracyclin, probenazole, streptomycin, tecloftalam, copper sulphate and other copper preparations.
- Carbamates e.g. alanycarb, aldicarb, aldoxycarb, allyxycarb, aminocarb, azamethiphos, bendiocarb, benfuracarb, bufencarb, butacarb, butocarboxim, butoxycarboxim, carbaryl, carbofuran, carbosulfan, chloethocarb, coumaphos, cyanofenphos, cyanophos, dimetilan, ethiofencarb, fenobucarb, fenothiocarb, formetanate, furathiocarb, isoprocarb, metam-sodium, methiocarb, methomyl, metolcarb, oxamyl, pirimicarb, promecarb, propoxur, thiodicarb, thiofanox, triazamate, trimethacarb, XMC, xylylcarb)
- Organophosphates e.g. acephate, azamethiphos, azinphos (-methyl, -ethyl), bromophos-ethyl, bromfenvinfos (-methyl), butathiofos, cadusafos, carbophenothion, chlorethoxyfos, chlorfenvinphos, chlormephos, chlorpyrifos (-methyl/-ethyl), coumaphos, cyanofenphos, cyanophos, chlorfenvinphos, demeton-s-methyl, demeton-s-methylsulphon, dialifos, diazinon, dichlofenthion, dichloriros/ddvp, dicrotophos, dimethoate, dimethylvinphos, dioxabenzofos, disulfoton, epn, ethion, ethoprophos, etrimfos, famphur, fenamipho
- Pyrethroids e.g. acrinathrin, allethrin (d-cis-trans, d-trans), beta-cyflutbrin, bifenthrin, bioallethrin, bioallethrin-s-cyclopentyl-isomer, bioethanometbrin, biopermethrin, bioresmethrin, chlovaporthrin, cis-cypermethrin, cis-resmethrin, cis-permethrin, clocythrin, cycloprothrin, cyfluthrin, cyhalothrin, cypermethrin (alpha-, beta-, theta-, zeta), cyphenothrin, DDT, deltamethrin, empenthrin (1R-isomer), esfenvalerate, etofenprox, fenfluthr
- Chloronicotinyls/neonicotinoids e.g. acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, nithiazine, thiacloprid, thiamethoxam
- Cyclodiene organochlorines e.g. camphechlor, chlordane, endosulfan, gamma HCH, HCH, heptachlor, lindane, methoxychlor
- Fiproles e.g. acetoprole, ethiprole, fipronil, vaniliprole
- Mectins e.g. abaraectin, avermectin, emamectin, emamectin-benzoate, ivermectin, milbemectin, milbemycin
- Diacylhydrazines e.g. chromafenozide, halofenozide, methoxyfenozide, tebufenozide
- Benzoylureas e.g. bistrifluoron, chlofluazuron, diflubenzuron, fluazuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, penfluoron, teflubenzuron, tifiumuron
- Organotins e.g. azocyclotin, cyhexatin, fenbutatin-oxide
- METT's e.g. fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad
- Tetronic acid insecticides e.g. spirodiclofen, spiromesifen
- Tetramic acid insecticides e.g. 3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4.5]dec-3-en-4-yl ethyl carbonate (alias: carbonic acid, 3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4.5]-dec-3-en-4-yl ethyl ester, CAS-Reg.-No.: 382608-10-8) and carbonic acid, cis-3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4.5]dec-3-en-4-yl ethyl ester (CAS-Reg.-No.: 203313-25-1)]
- Fumigants e.g. aluminium phosphide, methyl bromide, sulfa yl fluoride
- Mite growth inhibitors e.g. clofentezine, etoxazole, hexythiazox
- a mixture with other known active compounds, such as herbicides, fertilizers, growth regulators, safeners and/or semiochemicals is also possible.
- the active compounds according to the invention can furthermore be present in their commercially available formulations and in the use forms, prepared from these formulations, as a mixture with synergistic agents.
- Synergistic agents are compounds, which increase the action of the active compounds, without it being necessary for the synergistic agent added to be active itself.
- the active compounds according to the invention can furthermore be present in their commercially available formulations and in the use forms, prepared from these formulations, as a mixture with inhibitors which reduce degradation of the active compound after use in the vicinity of the plant, on the surface of parts of plants or in plant tissues.
- the content of the active compounds of the formula (I) of the present invention in a commercially useful application form can be varied in a wide range.
- concentration of the active compounds of the formula (I) of the present invention at the time of actual usage can be, for example, in the range of 0.0000001-100% by weight, preferably 0.00001-1% by weight.
- the compounds of the formula (I) of the present invention can be applied by usual methods suitable to the application forms.
- the active compounds of the present invention have a good stability against alkali on limed substrates and further show an excellent residual effectiveness on wood and soil.
- plants and their parts it is possible to treat all plants and their parts according to the invention.
- wild plant species and plant cultivars or those obtained by conventional biological breeding methods, such as crossing or protoplast fusion, and parts thereof, are treated.
- transgenic plants and plant cultivars obtained by genetic engineering if appropriate in combination with conventional methods (Genetically Modified Organisms), and parts thereof are treated.
- the term “parts” or “parts of plants” or “plant parts” has been explained above.
- plants of the plant cultivars which are in each case commercially available or in use are treated according to the invention.
- Plant cultivars are to be understood as meaning plants having certain properties (“traits”) which have been obtained by conventional breeding, by mutagenesis or by recombinant DNA techniques. These can be cultivars, bio- or genotypes.
- the treatment according to the invention may also result in superadditive (“synergistic”) effects.
- superadditive for example, reduced application rates and/or a widening of the activity spectrum and/or an increase in the activity of the substances and compositions to be used according to the invention, better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, increased flowering performance, easier harvesting, accelerated maturation, higher harvest yields, better quality and/or a higher nutritional value of the harvested products, better storage stability and/or processability of the harvested products are possible which exceed the effects which were actually to be expected.
- transgenic plants or plant cultivars which are preferably to be treated according to the invention include all plants which, in the genetic modification, received genetic material which imparted particularly advantageous useful traits to these plants.
- examples of such traits are better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, increased flowering performance, easier harvesting, accelerated maturation, higher harvest yields, better quality and/or a higher nutritional value of the harvested products, better storage stability and/or processability of the harvested products.
- transgenic plants which may be mentioned are the important crop plants, such as cereals (wheat, rice), maize, soya beans, potatoes, cotton, tobacco, oilseed rape and also fruit plants (with the fruits apples, pears, citrus fruits and grapes), and particular emphasis is given to maize, soya beans, potatoes, cotton, tobacco and oilseed rape.
- Traits that are emphasized are in particular increased defence of the plants against insects, arachnids, nematodes and worms by toxins formed in the plants, in particular those formed in the plants by the genetic material from Bacillus thuringiensis (for example by the genes CryIA(a), CryIA(b), CryIA(c), CryIIA, CryIIIA, CryIIIB2, Cry9c, Cry2Ab, Cry3Bb and CryIF and also combinations thereof) (hereinbelow referred to as “Bt plants”).
- Traits that are also particularly emphasized are the increased defence of the plants against fungi, bacteria and viruses by systemic acquired resistance (SAR), systemin, phytoalexius, elicitors and resistance genes and correspondingly expressed proteins and toxins. Traits that are furthermore particularly emphasized are the increased tolerance of the plants to certain herbicidally active compounds, for example imidazolinones, sulphonylureas, glyphosate or phosphinotricin (for example the “PAT” gene).
- the genes which impart the desired traits in question can also be present in combination with one another in the transgenic plants.
- Bt plants are maize varieties, cotton varieties, soya bean varieties and potato varieties which are sold under the trade names YIELD GARD® (for example maize, cotton, soya beans), KnockOut® (for example maize), StarLink® (for example maize), Bollgard® (cotton), Nucotn® (cotton) and NewLeaf® (potato).
- YIELD GARD® for example maize, cotton, soya beans
- KnockOut® for example maize
- StarLink® for example maize
- Bollgard® cotton
- Nucotn® cotton
- NewLeaf® potato
- herbicide-tolerant plants examples include maize varieties, cotton varieties and soya bean varieties which are sold under the trade names Roundup Ready® (tolerance to glyphosate, for example maize, cotton, soya bean), Liberty Link® (tolerance to phosphinotricin, for example oilseed rape), IMI® (tolerance to imidazolinones) and STS® (tolerance to sulphonylureas, for example maize).
- Herbicide-resistant plants plants bred in a conventional manner for herbicide tolerance
- Clearfield® for example maize
- the plants listed can be treated according to the invention in a particularly advantageous manner with the compounds of the general formula I and/or the active compound mixtures according to the invention.
- the preferred ranges stated above for the active compounds or mixtures also apply to the treatment of these plants. Particular emphasis is given to the treatment of plants with the compounds or mixtures specifically mentioned in the present text.
- N 1 - ⁇ 4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-2-methylphenyl ⁇ -N 2 -(1,1-dimethyl-2-methylsulfanylethyl)-3-iodophthalamide (0.5 g) was dissolved in dichloromethane, to which m-chloroperbenzoic acid (0.26 g) was added and the mixture was stirred for 5 hours under ice cooling. After finishing the reaction, the mixture was washed successively with aqueous solution of sodium thiosulfate, saturated aqueous solution of sodium bicarbonate and saturated aqueous solution of sodium chloride, and dried with anhydrous magnesium sulfate.
- N 1 - ⁇ 4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-2-methylphenyl ⁇ -N 2 -(1,1-dimethyl-2-methylsulfanylethyl)-3-iodophthalamide (0.30 g) was dissolved in dichloromethane, to which m-chloroperbenzoic acid (0.26 g) was added and the mixture was stirred at room temperature for 5 hours. After finishing the reaction, the mixture was washed successively with aqueous solution of sodium thiosulfate, saturated aqueous solution of sodium bicarbonate and saturated aqueous solution of sodium chloride, and dried with anhydrous magnesium sulfate.
- Trifluoroacetic anhydride (1.47 g) was added to 2-(3-Methyl-4-nitro-phenyl)-thioacetimidic acid 3,3,4,4,4-pentafluoro ester (130 g) and triethylamine (0.71 g) in dichloromethane (10 ml), and stirred at room temperature for 20 minutes. The reaction solution was washed with water, and the solvent was distilled off under the reduced pressure and the obtained residue was purified by silica gel column chromatography to obtain 2-(3-methyl-4-nitro-benzyl)-4-perfluoroethyl-thiazole (0.70 g).
- Leaves of sweet potato were soaked in the test solution diluted to a prescribed concentration with water, dried in the air and put in a dish of 9 cm diameter.
- Paddy rice (variety: Tamanishiki) planted in a pot was treated by spraying 50 ml per pot of the diluted aqueous solution of the prescribed concentration of the active compound prepared in the same manner as in the above-mentioned Biological Test Example 1.
- their foliage part was cut in 4-5 cm length, which were put in a dish with 9 cm diameter with a sheet of filter paper and 2 ml of water.
- Five larvae of Cnaphalocrocis medinalis Guenee at the second instar were put in the dish that was placed in a room at the constant temperature of 25° C.
- each rest each rest (each 1 ⁇ 3 amount) of foliage parts of rice plant were cut in the same manner and added to the dish.
- the number of dead larvae was counted and the rate of death was calculated. In this test the results of 2 dishes at 1 section were averaged.
Abstract
Novel benzenedicarboxamides of the formula (I) wherein X represents hydrogen, halogen atom, nitro, C1-6alkylsulfonyloxy, C1-6alkylsulfinyl, C1-6alkylsulfenyl or C1-6alkylsulfonyl, R1 represents C1-6alkyl, C1-6alkylthio-C1-6alkyl, C1-6alkylsulfinyl-C1-6alkyl or C1-6 alkylsulfonyl-C1-6alkyl, Y represents halogen or C1-6alkyl, m represents 0 or 1, A represents O, S, SO, SO2, CH2 or CH(CH3), and Q represents a 5- or 6-membered heterocyclic group that contains at least one hetero atom selected from the group consisting of N, O and S and can be optionally substituted; processes for their preparation, their intermediates and their use as insecticides.
Description
- The present invention relates to novel benzenedicarboxamides, processes for the preparation thereof, their intermediates and their use as insecticides.
- It was already known that phthalamide derivatives are useful as insecticides [see JP-A 11-240857 (1999), JP-A 2001-64258, JP-A 2001-64268, JP-A 2001-131141, JP-A 2003-40864, WO 01/21576 and WO 03/11028], and also that they show medicinal function [see JP-A 59-163353 (1984)].
- There have now been found novel benzenedicarboxamides of the formula (I)
- wherein
- X represents hydrogen, halogen atom, nitro, C1-6alkylsulfonyloxy, C1-6alkylsulfinyl, sulfenyl or C1-6alkylsulfonyl,
- R1 represents C1-6alkyl, C1-6alkylsulfinyl-C1-6alkyl or C1-4 alkylsulfonyl-C1-6alkyl,
- Y represents halogen or C1-6alkyl,
- m represents 0 or 1,
- A represents O, S, SO, SO2, CH2 or CH(CH3), and
- Q represents a 5- or 6-membered heterocyclic group that contains at least one hetero atom selected from the group consisting of N, O and S and can be optionally substituted.
- The compounds of the formula (I), according to the invention, can be obtained by
- (a) reacting compounds of the formula (II)
-
- wherein R1 and X have the same definitions as aforementioned,
- with compounds of the formula (III)
-
- wherein Y, A, m and Q have the same definitions as aforementioned,
- in the presence of inert solvents, and if appropriate in the presence of an acid catalyst,
or
- (b) reacting compounds of the formula (IV)
-
- wherein X, Y, A, m and Q have the same definitions as aforementioned,
- with compounds of the formula (V)
-
H2N—R1 (V) -
- wherein R1 has the same definitions as aforementioned,
- in the presence of inert solvents, and if appropriate in the presence of an acid catalyst,
or
- (c) reacting compounds of the formula (VI)
-
- wherein X and R1 have the same definitions as aforementioned,
- with the compounds of the formula (III),
-
- wherein Y, A, m and Q have the same definitions as aforementioned,
- in the presence of inert solvents, and if appropriate in the presence of an acid catalyst,
or
- (d) reacting compounds of the formula (VII)
-
- wherein X, Y, A, m and Q have the same definitions as aforementioned,
- with the compounds of the formula (V),
-
H2N—R1 (V) -
- wherein R1 has the same definitions as aforementioned,
- in the presence of inert solvents, and if appropriate in the presence of an acid catalyst,
or
- (e) compounds of the formula (VIII)
-
- wherein X, Y, A, in and Q have the same definitions as aforementioned,
- are reacted with the compounds of the formula (V),
-
H2N—R1 (V) -
- wherein R1 has the same definitions as aforementioned,
- in the presence of inert solvents, and if appropriate in the presence of an acid catalyst,
or
- (f) in the case that R1 represents C1-6alkylsulfinyl-C1-6alkyl or C1-6alkylsulfonyl-C1-6alkyl in the formula (I), reacting compounds of the formula (If)
-
- wherein
- R1f represents C1-6alkylthio-C1-6alkyl, and
- X, Y, A, in and Q have the same definitions as aforementioned,
- with an oxidizing agent in the presence of inert solvents.
- According to the present invention, the benzenedicarboxamides of the formula (I) show a strong insecticidal action.
- The compounds of the formula (I) are conceptually embraced in the general formula described in the aforementioned JP-A 11-240857 (1999). But they are not specifically disclosed at all in it and new compounds. Surprisingly, they show particularly remarkable insecticidal action compared with similar compounds described in the known prior art.
- In the present specification:
- “Halogen” represents fluorine, chlorine, bromine and iodine, and preferably represents fluorine, chlorine and bromine.
- “Alkyl” represents straight chain or branched chain C1-12alkyl, for example, methyl, ethyl, n- or iso-propyl, n-, iso-, sec- or tert-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, n-nonyl, n-decyl, n-undecyl, n-dodecyl, etc. and preferably represents C1-6alkyl.
- As each alkyl part in “alkylsulfonyloxy”, “alkylsulfenyl”, “alkylthioalkyl”, “alkylsulfinylalkyl”, “alkylsulfonylalkyl”, “alkoxy”, “alkylthio”, “alkylsulfinyl”, “alkylsulfonyl”, “haloalkyl”, “haloalkoxy”, “haloalkylthio”, “haloalkylsulfinyl”, “haloalkylsulfonyl” and “haloalkylcarbonyl”, there can be mentioned the same as described in the above-mentioned “alkyl” as examples.
- As each halogen part in “haloalkyl”, “haloalkoxy”, “haloalkylthio”, “haloalkylsulfinyl”, “haloalkylsulfonyl” and “haloalkylcarbonyl”, there can be mentioned the same as described in the above-mentioned “halogen” as examples.
- “5- or 6-membered heterocyclic group” contains at least one hetero atom selected from the group consisting of N, O and S, and preferably represents a heterocyclic group containing “one to three N atoms”, or “one O atom”, or “one S atom”, or “both one S atom and one to two N atoms”, or “both one O atom and one to two N atoms”, and as specific examples thereof, pyrazolyl, triazolyl, pyrazolinyl, imidazolyl, thiazolyl, pyrrolyl, furyl, thienyl, oxadiazolyl and pyrimidinyl, and moreover as most preferable examples thereof, pyrazolyl, triazolyl, pyrazolinyl, imidazolyl, thiazolyl, pyrrolyl, oxadiazolyl and pyrimidinyl are exemplified.
- In the compounds of the formula (I), according to the invention, the compounds in case that
- X represents hydrogen, fluorine, chlorine, bromine, iodine, nitro, C1-4 alkylsulfonyloxy, C1-4alkylsulfinyl, C1-4 alkylsulfenyl or C1-4 alkylsulfonyl,
- R1 represents C1-4alkyl, C1-4alkylthio-C1-4alkyl, C1-4alkylsulfinyl-C1-4alkyl or C1-4alkylsulfonyl-C1-4alkyl,
- Y represents fluorine, chlorine, bromine or C1-4alkyl,
- m represents 0 or 1,
- A represents O, S, SO, SO2, CH2 or CH(CH3), and
- Q represents 5-membered or 6-membered heterocyclic group that contains at least one hetero atom selected from a group consisting of N, O and S and can be optionally substituted by at least one selected from a group consisting of C1-6alkyl, C1-6alkoxy, C1-6alkylthio, C1-6alkylsulfinyl, C1-6alkylsulfonyl, C1-10haloalkoxy, C1-6haloalkoxy, C1-6haloalkylthio, C1-6haloalkylsulfinyl, C1-6haloalkylsulfonyl, C1-6haloalkylcarbonyl, halogen, oxo and hydroxy group, can be mentioned as preferable.
- Above all, in the compounds of the formula (I), the compounds in case that
- X represents hydrogen, fluorine, chlorine, bromine, iodine, nitro, methanesulfonyloxy, C1-2 alkylsulfenyl or C1-2 alkylsulfonyl,
- R1 represents isopropyl, C1-2alkylthio-C3-4alkyl, C1-2alkylsulfinyl-C3-4alkyl or C1-2alkylsulfonyl-C3-4alkyl,
- Y represents fluorine, chlorine or methyl,
- m represents 0 or 1,
- A represents O, S, SO, SO2, CH2 or CH(CH3), and
- Q represents heterocyclic group, selected from a group consisting of pyrazolyl, triazolyl, pyrazolinyl, imidazolyl, thiazolyl, pyrrolyl, oxadiazolyl and pyrimidinyl, that can be optionally substituted by at least one selected from the group consisting of C1-4alkyl, C1-4alkoxyl, C1-4alkylthio, C1-4alkylsulfinyl, C1-4alkylsulfonyl, C1-8haloalkyl, C1-4haloalkoxy, C1-4haloalkylthio, C1-4haloalkylsulfinyl, C1-4haloalkylsulfonyl, C1-4haloalkylcarbonyl, fluorine, chlorine, bromine, iodine, oxo and hydroxy group,
are particularly preferable. - The compounds of the formula (I), according to the present invention, include stereo isomers (R/S configuration) in case that the group R1 has an asymmetric carbon.
- The aforementioned process (a) can be illustrated by the following reaction scheme in case that, for example, 3-(1,1-dimethyl-2-methylthioethylimino)-4-iodo-3H-isobenzofuran-1-one and 1-(4-amino-3-methylbenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole are used as starting materials.
- The aforementioned preparation process (b) can be illustrated by the following reaction scheme in case that, for example, 2-{4-[3,5-bis(trifluoromethyl)pyrazole-1-ylmethyl]-2-methylphenyl}-4-fluoroisoindole-1,3-dione and (S)-1-methyl-2-methylthioethylamine are used as starting materials.
- The aforementioned preparation process (c) can be illustrated by the following reaction scheme in case that, for example, 3-iodo-N-(1,1-dimethyl-2-methylthioethyl)-phthalamic acid and 2-methyl-4-[1-(3-trifluoromethylpyrazole-1-yl)-ethyl]aniline are used as starting materials.
- The aforementioned preparation process (d) can be illustrated by the following reaction scheme in case that, for example, 1-[4-(4-iodo-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methyl-benzyl]-3,5-bis(trifluoromethyl)-(1,2,4)-triazol and 1-methyl-2-methylthioethylamine are used as starting materials.
- The aforementioned preparation process (e) can be illustrated by the following reaction scheme in case that, for example, N-{4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-2-methyl-phenyl}-6-iodo-phthalamic acid and 1-methyl-2-methylthioethylamine are used as starting materials.
- The aforementioned process (f) can be illustrated by the following reaction scheme in case that, for example, N2-(1-methyl-2-methylthioethyl)-3-iodo-N1-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]phenyl}phthalamide and m-chloroperbenzoic acid are used as starting materials.
- The compounds of the formula (II), used as starting materials in the above-mentioned preparation process (a), are per se known compounds and can be easily prepared according to the process described in, for example, JP-A 11-240857 (1999), JP-A 2001-131141.
- As specific examples of the compounds of the formula (Ia), used as starting materials in the preparation process (a), there can be mentioned the following:
- 3-isopropylimino-3H-isobenzofuran-1-one,
- 4-fluoro-3-isopropylimino-3H-isobenzofuran-1-one,
- 4-chloro-3-isopropylimino-3H-isobenzofuran-1-one,
- 4-bromo-3-isopropylimino-3H-isobenzofuran-1-one,
- 4-iodo-3-isopropylimino-3H-isobenzofuran-1-one,
- 3-(1-methyl-2-methylsulfanyl-ethylimino)-3H-isobenzofuran-1-one,
- 4-fluoro-3-(1-methyl-2-methylsulfanyl-ethylimino)-3H-isobenzofuran-1-one,
- 4-chloro-3-(1-methyl-2-methylsulfanyl-ethylimino)-3H-isobenzofuran-1-one,
- 4-bromo-3-(1-methyl-2-methylsulfanyl-ethylimino)-3H-isobenzofuran-1-one,
- 4-iodo-3-(1-methyl-2-methylsulfanyl-ethylimino)-3H-isobenzofuran-1-one,
- 3-(1,1-dimethyl-2-methylsulfanyl-ethylimino)-3H-isobenzofuran-1-one,
- 3-(1,1-dimethyl-2-methylsulfanyl-ethylimino)-4-fluoro-3H-isobenzofuran-1-one,
- 4-chloro-3-(1,1-dimethyl-2-methylsulfanyl-ethylimino)-3H-isobenzofuran-1-one,
- 4-bromo-3-(1,1-dimethyl-2-methylsulfanyl-ethylimino)-3H-isobenzofuran-1-one,
- 3-(1,1-dimethyl-2-methylsulfanyl-ethylimino)-4-iodo-3H-isobenzofuran-1-one,
- 3-isopropylimino-1-oxo-1,3-dihydro-isobenzofuran-4-yl methanesulfonate
- 3-(1-methyl-2-methylsulfanyl-ethylimino)-1-oxo-1,3-dihydro-isobenzofuran-4-yl methanesulfonate
- 3-(1,1-dimethyl-2-methylsulfanyl-ethylimino)-1-oxo-1,3-dihydro-isobenzofuran-4-yl
methanesulfonate and so on. - The compounds of the formula (III), used as starting materials in the above-mentioned preparation process (a), which are partly novel compounds that are not described in the existing literature yet, can be obtained, for example, by reducing compounds of the formula (IX)
- wherein Y, A, m and Q have the same definitions as aforementioned,
according to the catalytic hydrogen reduction process, a well-known process in the field of organic chemistry, with hydrogen in the presence of a catalytic reduction catalyst, for example, palladium carbon, Raney nickel, platinum oxide, etc. - The above-mentioned catalytic hydrogen reduction process can be conducted in an adequate diluent.
- As examples of the diluent used in that case there can be mentioned ethers, for example, ethyl ether, methyl ethyl ether, isopropyl ether, butyl ether, dioxane, tetrahydrofuran (THF), etc.; alcohols, for example, methanol, ethanol, isopropanol, butanol, ethylene glycol, etc. and as catalytic reduction catalyst there can be mentioned, palladium carbon, Raney nickel, platinum oxide, etc.
- The reaction can be conducted at the temperatures generally from about 0 to about 100° C., preferably from room temperature (20° C.) to about 80° C.
- Said reaction can be conducted usually under normal pressure but can be operated optionally also under elevated pressure.
- For example, a compound of the formula (III) can be obtained by hydrogenating the compounds of the formula (IX) in a diluent, for example, ethanol, in the presence of 0.1-10% (w/w) palladium carbon.
- Also by a reduction reaction using metals etc. instead of catalytic hydrogen reduction, the compounds of the formula (III) can be obtained from the compounds of the formula (IX).
- As a reduction process using metals etc., there can be mentioned, for example, a process of reacting iron powder in acetic acid, a process of reacting zinc dust under neutral condition (Organic Syntheses Collective Vol. II, p. 447), a process of reacting stannic chloride under acidic condition (Organic Syntheses Collective Vol. II, p. 254), a process of reacting titanium trichloride under neutral condition, etc.
- The compounds of the formula (IX) are novel compounds and can be obtained by reacting the compounds of the formula (IX) wherein A represents other than oxygen atom, for example, compounds of the formula (X)
- wherein
- Y and m have the same definitions as aforementioned,
- A1 represents S, SO, SO2, CH2 or CH(CH3), and
- M represents chlorine, bromine or methanesulfonyloxy,
with compounds of the formula (XI) -
H-Q (XI) - wherein Q has the same definition as aforementioned.
- The compounds of the formula (X), are well known in the field of organic chemistry and described in publications, for example, Chem. Abstr., Vol. 58, 3444e (1963); Bull. Soc. Claim. Fr. (1934), p. 539-545; J. Chem. Res. Miniprint, Vol. 8 (1987), p. 2133-2139; J. Chem. Soc. B (1967), p. 1154-1158; J. Chem. Soc. (1961), p. 221-222; J. Amer. Chem. Soc., Vol. 111 (1989), p. 5880-5886; J. Amer. Chem. Soc., Vol. 96 (1974), p. 7770-7781; Can. J. Chem., Vol. 68 (1990), p. 1450-1455, Tetrahedron Letter, vol. 35 (1994), p. 7391-7394.
- As specific examples of the compounds of the formula (X), there can be mentioned specifically
- 2-methyl-4-nitrobenzyl chloride,
- 3-methyl-4-nitrobenzyl chloride
- 4-nitrobenzyl methanesulfonate
- 2-methyl-4-nitrobenzyl methanesulfonate
- 3-methyl-4-nitrobenzyl methanesulfonate,
- 4-nitrobenzenesulfenyl chloride,
- 4-nitrobenzenesulfinyl chloride,
- 4-nitrobenzenesulfonyl chloride,
- 4-nitro-3-methylbenzenesulfonyl chloride,
- 3-fluoro-4-nitrobenzyl bromide,
- 3-chloro-4-nitrobenzyl chloride and so on.
- The nitro-substituted benzoic acids and their esters, starting materials of the compounds of the formula (X), are known compounds described in, for example, Chem. Ber., Vol. 52 (1919), p. 1083; Bull. Soc. Chim. Fr. (1962), p. 2255-2261; Tetrahedron (1985), p. 115-118; Chem. Pharm. Bull., Vol. 41 (1993), p. 894-906; WO 2001/042227.
- The compounds of the formula (XI) include known compounds and as their specific examples, there can be mentioned:
- 3,5-bis(trifluoromethyl)-1H-pyrazole,
- 5-difluoromethoxy-3-trifluoromethyl-1H-pyrazole,
- 4-pentafluoroethyl-1H-pyrazole,
- 5-hexafluoro-n-propyl-1H-pyrazole,
- 3,5-bis(trifluoromethyl)-1H-(1,2,4)-triazole,
- 5-pentafluoroethyl-3-trifluoromethyl-1H-(1,2,4)-triazole,
- 5-difluoromethyl-3-trifluoromethyl-1H-(1,2,4) triazole,
- 5-hydroxy-3,5-bis(trifluoromethyl)-1H-4,5-dihydropyrazole,
- 2,4-bis(trifluoromethyl)-1H-imidazole,
- 3-(2,2,2-trifluoroethyl)-5-trifluoromethyl-1,2-dihydro-(1,3,4)-triazol-2-one,
- 2,5-bis(trifluoromethyl)-(1,3,4)-triazole,
- 5-pentafluoroethyl-1H-pyrazole,
- 3-pentafluoroethyl-1H-pyrazole,
- 4-bromo-3-trifluoromethyl-1H-pyrazole,
- 3-trifluoromethyl-1H-pyrazole,
- 5-(difluoromethyl)-1,2-dihydro-2-methyl-3H-(1,2,4)-triazol-3-one,
- 4-(trifluoromethyl)-2H-1,2,3-triazole,
- 4-iodo-3-pentafluoroethyl-1H-pyrazole,
- 3-pentafluoroethyl-4-(1,1,2,2-tetrafluoroethyl)-1H-pyrazole,
- 3,4-bis-pentafluoroethyl-1H-pyrazole,
- 3,5-diiodo-4-methyl-1H-pyrazole,
- 3-Heptafluoropropylsulfanyl-5-trifluoromethyl-1H-(1,2,4)-triazole,
- 3,5-bis(pentafluoroethyl)-1H-(1,2,4)-triazole and so on.
- The above-mentioned reaction of the compounds of the formula (X) with the compounds of the formula (XI) can be conducted in an adequate diluent.
- As examples of the diluent used in that case there can be mentioned, for example, aliphatic, alicyclic and aromatic hydrocarbons (may be optionally chlorinated), for example, pentane, hexane, cyclohexane, petroleum ether, ligroine, benzene, toluene, xylene, dichloromethane, etc.; ethers, for example, ethyl ether, methyl ethyl ether, isopropyl ether, butyl ether, dioxane, dimethoxyethane (DME), tetrahydrofuran (THF), diethylene glycol dimethyl ether (DGM), etc.; ketones, for example, acetone, methyl ethyl ketone (MEK), methyl isopropyl ketone, methyl isobutyl ketone (MIBK), etc.; nitriles, for example, acetonitrile, propionitrile, acrylonitrile, etc.; esters, for example, ethyl acetate, amyl acetate, etc.; acid amides, for example, dimethylformamide (DMF), dimethylacetamide (DMA), N-methylpyrrolidone, 1,3-dimethyl-2-imidazolidinone, hexamethyl phosphoric triamide (HMPA), etc.
- The reaction can be conducted in the presence of an acid binder and as said acid binder there can be mentioned, for example, as inorganic base, hydrides, hydroxides, carbonates, bicarbonates, etc. of alkali metals or alkaline earth metals, for example, sodium hydride, lithium hydride, sodium hydrogen carbonate, potassium hydrogen carbonate, sodium carbonate, potassium carbonate, lithium hydroxide, sodium hydroxide, potassium hydroxide, calcium hydroxide, etc.; inorganic alkali metal amides, for example, lithium amide, sodium amide, potassium amide, etc.; as organic base, alcoholates, tertiary amines, dialkylaminoanilines and pyridines, for example, triethylamine, 1,1,4,4-tetramethylethylenediamine (TMEDA), N,N-dimethylaniline, N,N-diethylaniline, pyridine, 4-dimethylaminopyridine (DMAP), 1,4-diazabicyclo[2,2,2]octane (DABCO), 1,8-diazabicyclo[5,4,0]undec-7-ene (DBU), etc.
- The above-mentioned reaction can also be conducted by a process using a phase transfer catalyst in the presence of a diluent. As examples of the diluent used in that case there can be mentioned water; aliphatic, alicyclic and aromatic hydrocarbons (may be optionally chlorinated), for example, pentane, hexane, cyclohexane, petroleum ether, ligroine, benzene, toluene, xylene, etc.; ethers, for example, ethyl ether, methyl ethyl ether, isopropyl ether, butyl ether, dioxane, dimethoxyethane (DME), tetrahydrofuran diethylene glycol dimethyl ether (DGM), etc. As examples of the phase transfer catalyst, quaternary ions, for example, tetramethylammonium bromide, tetrapropylammonium bromide, tetrabutylammonium bromide, tetrabutylammonium bissulfate, tetrabutylammonium iodide, trioctylmethylammonium chloride, benzyltriethylammonium bromide, butylpyridinium bromide, heptylpyridinium bromide, benzyltriethylammonium chloride, etc.; crown ethers, for example, dibenzo-18-crown-6, dicyclohexyl-18-crown-6, 18-crown-6, etc.; cryptands, for example, [2.2.2]-cryptate, [2.1.1]-cryptate, [2.2.1]-cryptate, [2.2.B]-cryptate, [3.2.2]-cryptate, etc.
- The above-mentioned reaction can be conducted in a substantially wide range of temperature. It is adequate to conduct it at the temperatures in a range of generally from about 0 to about 200° C., preferably from room temperature (20° C.) to about 150° C.
- Although said reaction is conducted desirably under normal pressure, it can be operated also under elevated pressure or under reduced pressure.
- In conducting the above-mentioned reaction, the aimed compounds of the formula (IX) can be obtained, for example, by reacting 1 mole to a little excess mole amount of the compounds of the formula (XI) to 1 mole of the compounds of the formula (X) in a diluent, for example, DMF, in the presence of potassium carbonate.
- As the compounds of the formula (IX) obtained according to the above-mentioned process, there can be mentioned, for example, the corresponding 4-nitrobenzyl derivatives to the 4-aminobenzyl derivatives of the formula (III) mentioned hereinafter. And, as one typical example, 1-(3-methyl-4-nitrobenzyl)-3,5-bis-(trifluoromethyl)-1H-pyrazole can be mentioned.
- Furthermore, in a case where Q represents 2-thiazolyl in the formula (IX), as a specific example, 2-(3-methyl-4-nitrobenzyl)-4-pentafluoroethyl-thiazole can be prepared by the following way in which a known compound, 3-methyl-4-niirobenzylcyanide (see J. Chem. Soc., vol. 97 (1910), p. 2260) is reacted with hydrogen sulfide, and then the product, 3-methyl-4-nitro-benzylthioamide is reacted with a commercial product, 1-bromo-3,3,4,4,4-pentafluoro-2-butanone and then cyclized, according to a method described in J. Heterocycl. Chem., vol. 28 (1991) p. 907 to 911.
- In a case where Q represents 1,3,4-oxadiazol-2-yl in the formula (IX), as a specific example, 2-(3-methyl-4-nitrophenyl)-5-trifluoromethyl-1,3,4-oxazole can easily be obtained, according to a method described in Heterocycles, (1994), vol. 38, p. 981 to 990, from the corresponding aldoxime as a starting material which can be prepared by a method described in Justus Liebigs Ann. Chem., (1927) vol. 45, p. 166.
- And, as another specific example, 2-(3-methyl-4-nitrobenzyl)-5-trifluoromethyl-1,3,4-oxazole can easily be obtained, according to a method described in Heterocycles, (1994) vol. 38, p. 981 to 990, from the corresponding 3-methyl-4-nitrobenzaldehyde oxime. In the above preparation, the oxime can be obtained from a known 3-methyl-4-nitrobenzaldehyde [see J. Chem. Soc. B, (1967) p. 1154 to 1158] as a starting material, according to methods described in J. Chem. Soc. C, (1969) p. 986 to 990 and then Tetrahedron Letter, vol. 35 (1994) p. 9099 to 9100.
- In a case where Q represents 2H-1,2,3-triazol-2-yl in the formula (IX), as a specific example, 2-(3-methyl-4-nitrobenzyl)-2H-4-trifluoromethyl-1,2,3-triazole can easily be prepared by a reaction of a known 3-methyl-4-nitrobenzyl chloride with a known 2H-4-trifluoromethyl-1,2,3-triazole described in J. Chem. Soc., Perkin Transaction 2, vol. 10 (1989) p. 1355 to 1375.
- In a case where Q represents 1H-1,2,4-triazol-1-yl in the formula (IX), as a specific example, 5-(3-methyl-4-nitrophenylsulfanyl)-1-methyl-3-trifluoromethyl-1H-1,2,4-triazole can easily be prepared by a reaction of 1-fluoro-3-methyl-4-nitrobenzene with a known 5-mercapto-1-methyl-3-trifluoromethyl-1H-1,2,4-triazole described in J. Med. Chem., vol. 35 (1992) p. 2103 to 2112, according to the same preparation as Synthesis Example 47 hereinafter.
- In a case where Q represents 1,2,4-oxazol-3-yl in the formula (IX), as a specific example, 3-(3-methyl-4-nitrophenyl)-5-trifluoromethyl-1,2,4-oxazole can easily be obtained from 3-methyl-4-nitrobenzamideoxime, according to a method described in 3. Org. Chem., vol. 68(2), 2003, p. 605-608. And, 3-methyl-4-nitrobenzamideoxime can be prepared by a reaction of a commercial 3-methyl-4-nitrobenzonitrile with hydroxylamine, according to a method described in Chem. Ber., vol. 22 (1889), p. 2428.
- And, as another specific example, 3-(3-methyl-4-nitrobenzyl)-5-trifluoromethyl-1,2,4-oxazole can easily be obtained from 2-(3-methyl-4-nitrophenyl)-acetamideoxime as well, according to a method described in J. Org. Chem., vol. 68(2), 2003, p. 605-608. And, 2-(3-methyl-4-nitrophenyl)-acetamideoxime can be prepared by a reaction of 3-methyl-4-nitrophenyl-acetonitrile with hydroxylamine, according to a method described in Chem. Ber., vol. 22 (1889), p. 2428.
- In a case where Q represents 1H-1,2,4-triazol-3-yl in the formula (IX), as specific examples, 1-methyl-3-(3-methyl-4-nitrophenyl)-5-trifluoromethyl-1H-1,2,4-triazole can easily be prepared by a reaction of the above 3-(3-methyl-4-nitrophenyl)-5-trifluoromethyl-1,2,4-oxazole with methylhydrazine, according to a method described in J. Org. Chem., vol. 68(2), 2003, p. 605-608, and also 1-methyl-3-(3-methyl-4-nitrobenzyl)-5-trifluoromethyl-1H-1,2,4-thiazole can be done by a reaction of the above 3-(3-methyl-4-nitrobenzyl)-5-trifluoromethyl-1,2,4-oxazole with methylhydrazine as well.
- The compounds of the formula (IX) can be prepared, besides the above-mentioned preparation process, also by the process to be mentioned later in Examples as an alternative.
- As specific examples of the compounds of the formula (III) there can be mentioned, for example, the following:
- 1-(4-amino-3-methylbenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole,
- 1-(4-amino-3-methylbenzyl)-5-difluoromethoxy-3-trifluoromethyl-1H-pyrazole,
- 1-(4-amino-3-methylbenzyl)-4-pentafluoroethyl-1H-pyrazole,
- 1-(4-amino-3-methylbenzyl)-5-hexafluoro-n-propyl-1H-pyrazole,
- 1-(4-amino-3-methylbenzyl)-3,5-bis(trifluoromethyl)-1H-(1,2,4)-triazole,
- 1-(4-amino-3-methylbenzyl)-5-pentafluoroethyl-3-trifluoromethyl-1H-(1,2,4)-triazole,
- 1-(4-amino-3-methylbenzyl)-5-difluoromethyl-3-trifluoromethyl-1H-(1,2,4)-triazole,
- 4-(4-amino-3-methylbenzyl)-5-difluoromethoxy-1-difluoromethyl-3-trifluoromethyl-1H-pyrazole,
- 4-(4-amino-3-methylbenzyl)-3-difluoromethoxy-1-difluoromethyl-5-trifluoromethyl-1H-pyrazole,
- 1-(4-amino-3-methylbenzyl)-5-hydroxy-3,5-bis(trifluoromethyl)-1H-4,5-dihydropyrazole,
- 1-(4-amino-3-methylbenzyl)-2,4-bis(trifluoromethyl)-1H-imidazole,
- 4-(4-amino-3-methylbenzyl)-2-(2,2,2-trifluoroethyl)-5-trifluoromethyl-2,4-dihydro-3H-(1,2,4)-triazol-3-one,
- 2-(4-amino-3-methylbenzyl)-4-(2,2,2-trifluoroethyl)-5-trifluoromethyl-2,4-dihydro-3H-(1,2,4)-triazol-3-one,
- 1-(4-amino-3-methylbenzyl)-2,5-bis(trifluoromethyl)-1,3,4-triazole,
- 2-(4-amino-3-methylbenzyl)-4,6-bis(trifluoromethyl)-pyrimidine,
- 2-(4-amino-3-methylphenoxy)-4,6-bis(trifluoromethyl)-pyrimidine,
- 1-(4-amino-3-methylphenyl)-3,5-bis(trifluoromethyl)-1H-pyrazole,
- 1-(4-amino-3-methylphenyl)-5-pentafluoroethyl-1H-pyrazole,
- 1-(4-amino-3,7-methylphenyl)-3-pentafluoroethyl-1H-pyrazole,
- 1-(4-amino-3-methylphenyl)-4-pentafluoroethyl-1H-pyrazole,
- 1-(4-amino-3-methylphenyl)-3-methyl-5-trifluoromethyl-1H-pyrazole,
- 1-(4-amino-3-methylphenyl)-5-methyl-3-trifluoromethyl-1H-pyrazole,
- 1-(4-amino-3-methylphenyl)-3-pentafluoroethyl-5-trifluoromethyl-1H-pyrazole,
- 1-(4-amino-3-methylphenyl)-4-bromo-3-trifluoromethyl-1H-pyrazole,
- 1-(4-amino-3-methylphenyl)-3-trifluoromethyl-1H-pyrazole,
- 1-(4-amino-3-methylphenyl)-5-hydroxy-3-(2,2,2-trifluoroethyl)-5-trifluoromethyl-1H-4,5-dihydropyrazole,
- 5-(4-amino-3-methylphenyl)-1-(2,2,2-trifluoroethyl)-3-trifluoromethyl-pyrazole,
- 5-(4-amino-3-methylphenyl)-1-difluoromethyl-3-trifluoromethyl-pyrazole,
- 3-(4-amino-3-methylphenyl)-1-difluoromethyl-3-difluoromethoxy-pyrazole,
- 1-(4-amino-3-methylbenzyl)-3,4-bis(pentafluoroethyl)-1H-pyrazole,
- 1-(4-amino-3-methylbenzyl)-3,5-bis(pentafluoroethyl)-1H-pyrazole,
- 1-(4-amino-3-methylbenzyl)-3,4-bis(pentafluoropropyl)-1H-pyrazole,
- 1-(4-amino-3-methylbenzyl)-3,5-bis(pentafluoropropyl)-1H-pyrazole,
- 1-(4-amino-3-methylbenzyl)-3,5-bis(pentafluoroethyl)-1H-(1,2,4)-triazole,
- 1-(4-amino-3-methylbenzyl)-2,5-bis(pentafluoroethyl)-1H-(1,3,4)-triazole,
- 2-(4-amino-3-methylphenyl)-5-(trifluoromethyl)-1,3,4-oxadiazole,
- 2-(4-amino-3-methylphenyl)-5-(pentafluoroethyl)-1,3,4-oxadiazole,
- 2-(4-amino-3-methylphenyl)-5-(heptafluoropropyl)-1,3,4-oxadiazole,
- 2-(4-amino-3-methylbenzyl)-5-(trifluoromethyl)-1,3,4-oxadiazole,
- 2-(4-amino-3-methylbenzyl)-4-(trifluoromethyl)-2H-1,2,3-triazole,
- 2-(4-amino-3-methylbenzyl)-4-(pentafluoroethyl)-thiazole,
- 5-(4-amino-3-methylphenyl)sulfanyl-1-methyl-3-(trifluoromethyl)-1H-1,2,4-triazole,
- 3-(4-amino-3-methylphenyl)-5-(trifluoromethyl)-1,2,4-oxadiazole,
- 3-(4-amino-3-methylphenyl)-1-methyl-5-(trifluoromethyl)-1H-1,2,4-triazole,
- 1-(4-amino-3-chlorobenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole,
- 1-(4-amino-3-fluorobenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole and so on.
- The compounds of the formula (IV), used as starting materials in the above-mentioned preparation process (b), are novel compounds and can be easily obtained according to the process described in Japanese Laid-open Patent Publication No. 61-246161 (1986), for example, by reacting compounds of the formula (XD)
- wherein X has the same definition as aforementioned,
with the compounds of the formula (III). - wherein Y, A, m and Q have the same definitions as aforementioned.
- The reaction can be conducted in an adequate diluent. As the diluent used in that case there can be mentioned, for example, aliphatic, alicyclic and aromatic hydrocarbons (may be optionally chlorinated), for example, pentane, hexane, cyclohexane, petroleum ether, ligroin, benzene, toluene, xylene, dichloromethane, chloroform, carbon tetrachloride, 1,2-dichloroethane, chlorobenzene, dichlorobenzene, etc.; ethers, for example, ethyl ether, methyl ethyl ether, isopropyl ether, butyl ether, dioxane, dimethoxyethane (DME), tetrahydrofuran (THF), diethylene glycol dimethyl ether (DGM), etc.; esters, for example, ethyl acetate, amyl acetate, etc.; acid amides, for example, dimethylformamide (DMF), dimethylacetamide (DMA), N-methylpyrrolidone, 1,3-dimethyl-2-imidazolidinone, hexamethyl phosphoric triamide (HMPA), etc.; acids, for example, acetic acid etc.
- The reaction can be conducted in a substantially wide range of temperature. It is adequate to conduct it at the temperatures in a range of generally from room temperature (20° C.) to about 200° C., preferably from room temperature to 150° C.
- Although said reaction is conducted desirably under normal pressure, it can be operated also under elevated pressure or under reduced pressure.
- In conducting the reaction, the aimed compounds of the formula (IV) can be obtained, for example, by reacting equimolar to a little excess mole amount of the compounds of the formula (II) to 1 mole of the compounds of the formula (XII) in a diluent, for example, acetic acid.
- Many of the compounds of the above-mentioned formula (XII) are publicly known, and as their specific examples there can be mentioned, phthalic anhydride, 3-fluorophthalic anhydride, 3-chlorophthalic anhydride, 3-bromophthalic anhydride, 3-iodophthalic anhydride, 3-methanesulfonyloxyphthalic anhydride, etc.
- Among the above-mentioned compounds, 3-methanesulfonyloxyphthalic anhydride can be easily obtained from 3-hydroxyphthalic anhydride and methanesulfonyl chloride according to the process described in Tetrahedron Letters Vol. 29, p. 5595-8 (1988).
- As specific examples of the compounds of the formula (IV), used as starting materials in the preparation process (b), there can be mentioned the following:
- 4-chloro-2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]phenyl}-isoindole-1,3-dione,
- 2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl-methyl]-phenyl}-isoindole-1,3-dione,
- 4-chloro-2-[2-methyl-4-(5-difluoromethoxy-3-trifluoromethyl-1H-pyrazol-1-yl-methyl)-phenyl]-isoindole-1,3-dione,
- 4-chloro-2-[2-methyl-4-(4-pentafluoroethyl-1H-pyrazol-1-yl-methyl)-phenyl]-isoindole-1,3-dione,
- 4-bromo-2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl-methyl]-phenyl}-isoindole-1,3-dione,
- 4-bromo-2-[2-methyl-4-(5-difluoromethoxy-3-trifluoromethyl-1H-pyrazol-1-yl-methyl)-phenyl]-isoindole-1,3-dione,
- 4-bromo-2-[2-methyl-4-(4-pentafluoroethyl-1H-pyrazol-1-yl-methyl)-phenyl]-isoindole-1,3-dione,
- 4-iodo-2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl-methyl]-phenyl}-isoindole-1,3-dione,
- 4-iodo-2-[2-methyl-4-(5-difluoromethoxy-3-trifluoromethyl-1H-pyrazol-1-yl-methyl)-phenyl]-isoindole-1,3-dione,
- 4-iodo-2-[2-methyl-4-(4-pentafluoroethyl-1H-pyrazol-1-yl-methyl)-phenyl]-isoindole-1,3-dione,
- 4-iodo-2-[2-methyl-4-(5-hexafluoro-n-propyl-1H-pyrazol-1-yl-methyl)-phenyl]-isoindole-1,3-dione,
- 4-methanesulfonyloxy-2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl-methyl]-phenyl}-isoindole-1,3-dione,
- 4-chloro-2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-(1,2,4)-triazol-1-yl-methyl]-phenyl}-isoindole-1,3-dione,
- 4-chloro-2-{2-methyl-4-[5-pentafluoroethyl-3-trifluoromethyl-1H-(1,2,4)-triazol-1-yl-methyl]-phenyl}-isoindole-1,3-dione,
- 4-chloro-2-{2-methyl-4-[5-difluoromethoxy-1-difluoromethyl-1H-(1,2,4)-triazol-1-yl-methyl]-phenyl}-isoindole-1,3-dione,
- 4-iodo-2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-(1,2,4)-triazol-1-yl-methyl]-phenyl}-isoindole-1,3-dione,
- 4-iodo-2-{2-methyl-4-[5-pentafluoroethyl-3-trifluoromethyl-1H-(1,2,4)-triazol-1-yl-methyl]-phenyl}-isoindole-1,3-dione,
- 4-iodo-2-{2-methyl-4-[5-difluoromethyl-3-trifluoromethyl-1H-(1,2,4)-triazol-1-yl-methyl]-phenyl}-isoindole-1,3-dione,
- 4-methanesulfonyloxy-2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-(1,2,4)-triazol-1-yl-methyl]-phenyl}-isoindole-1,3-dione,
- 4-iodo-2-[2-methyl-4-(5-difluoromethoxy-1-difluoromethyl-3-trifluoromethyl-1H-pyrazol-4-yl-methyl)-phenyl]-isoindole-1,3-dione,
- 4-iodo-2-[2-methyl-4-(5-hydroxy-3,5-bis(trifluoromethyl)-1H-4,5-dihydropyrazol-1-yl-methyl)-phenyl]-isoindole-1,3-dione,
- 4-iodo-2-{2-methyl-4-[2,4-bis(trifluoromethyl)-1H-imidazol-1-yl-methyl]-phenyl}-isoindole-1,3-dione,
- 4-iodo-2-{2-methyl-4-[3-(2,2,2-trifluoroethyl)-5-trifluoromethyl-1,2-dihydro-(1,3,4)-triazol-2-on-1-yl-methyl]-phenyl}-isoindole-1,3-dione,
- 4-iodo-2-{2-methyl-4-[3-(2,2,2-trifluoroethyl)-3-trifluoromethyl-4,5-dihydro-(1,2,4)-triazol-5-on-1-yl-methyl]-phenyl}-isoindole-1,3-dione,
- 4-iodo-2-{2-methyl-4-[2,5-bis(trifluoromethyl)-(1,3,4)-triazol-1-yl-methyl]-phenyl}-isoindole-1,3-dione,
- 4-iodo-2-{2-methyl-4-[4,6-bis(trifluoromethyl)pyrimidin-2-yl-methyl]-phenyl}-isoindole-1,3-dione,
- 4-iodo-2-{2-methyl-4-[4,6-bis(trifluoromethyl)pyrimidin-2-yloxy]-phenyl}-isoindole-1,3-dione,
- 4-chloro-2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl}-isoindole-1,3-dione,
- 4-chloro-2-[2-methyl-4-(5-pentafluoroethyl-1H-pyrazol-1-yl)-phenyl]-isoindole-1,3-dione,
- 4-chloro-2-[2-methyl-4-(3-pentafluoroethyl-1H-pyrazol-1-yl)-phenyl]-isoindole-1,3-dione,
- 4-chloro-2-[2-methyl-4-(4-pentafluoroethyl-1H-pyrazol-1-yl)-phenyl]-isoindole-1,3-dione,
- 4-iodo-2-[2-methyl-4-[3-methyl-5-trifluoromethyl-1H-pyrazol-1-yl]-phenyl]-isoindole-1,3-dione,
- 4-iodo-2-[2-methyl-4-(5-methyl-3-trifluoromethyl-1H-pyrazol-1-yl)-phenyl]-isoindole-1,3-dione,
- 4-iodo-2-[2-methyl-4-(3-pentafluoroethyl-5-trifluoromethyl-1H-pyrazol-1-yl)-phenyl]-isoindole-1,3-dione,
- 4-iodo-2-[2-methyl-4-(4-bromo-3-trifluoromethyl-1H-pyrazol-1-yl)phenyl]-isoindole-1,3-dione,
- 4-iodo-2-[2-methyl-4-(3-trifluoromethyl-1H-pyrazol-1-yl)-phenyl]-isoindole-1,3-dione,
- 4-iodo-2-{2-methyl-4-[5-hydroxy-3-(2,2,2-trifluoroethyl)-5-trifluoromethyl-1H-4,5-dihydropyrazol-1-yl]-phenyl}-isoindole-1,3-dione,
- 4-iodo-2-{2-methyl-4-[1-(2,2,2-trifluoroethyl)-3-trifluoromethyl-pyrazol-5-yl]-phenyl}-isoindole-1,3-dione,
- 4-iodo-2-[2-methyl-4-(1-difluoromethyl-3-trifluoromethyl-pyrazol-5-yl)-phenyl]-isoindole-1,3-dione,
- 4-iodo-2-[2-methyl-4 (1-difluoromethyl-3-difluoromethoxy-pyrazol-3-yl)-phenyl]-isoindole-1,3-dione,
- 4-iodo-2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl}-isoindole-1,3-dione,
- 4-iodo-2-[2-methyl-4-(5-pentafluoroethyl-1H-pyrazol-1-yl)-phenyl]-isoindole-1,3-dione,
- 4-iodo-2-[2-methyl-4-(3-pentafluoroethyl-1H-pyrazol-1-yl)-phenyl]-isoindole-1,3-dione,
- 4-iodo-2-[2-methyl-4-(4-pentafluoroethyl-1H-pyrazol-1-yl)-phenyl]-isoindole-1,3-dione,
- 4-bromo-2-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl}-isoindole-1,3-dione,
- 4-bromo-2-[2-methyl-4-(5-pentafluoroethyl-1H-pyrazol-1-yl)-phenyl]-isoindole-1,3-dione,
- 4-bromo-2-[2-methyl-4-(3-pentafluoroethyl-1H-pyrazol-1-yl)-phenyl]-isoindole-1,3-dione,
- 4-bromo-2-[2-methyl-4-(4-pentafluoroethyl-1H-pyrazol-1-yl)-phenyl]-isoindole-1,3-dione,
- 4-chloro-2-{2-methyl-4-[3,4-bis(pentafluoroethyl)-1H-pyrazol-1-ylmethyl]-phenyl}-isoindole-1,3-dione,
- 4-chloro-2-{2-methyl-4-[3,5-bis(pentafluoroethyl)-1H-pyrazol-1-ylmethyl]-phenyl}-isoindole-1,3-dione,
- 4-chloro-2-{2-methyl-4-[3,4-bis(heptafluoropropyl)-1H-pyrazol-1-ylmethyl]-phenyl}-isoindole-1,3-dione,
- 4-chloro-2-{2-methyl-4-[3,5-bis(heptafluoropropyl)-1H-pyrazol-1-ylmethyl]-phenyl}-isoindole-1,3-dione,
- 4-chloro-2-[2-methyl-4-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl)-phenyl]-isoindole-1,3-dione,
- 4-chloro-2-[2-methyl-4-(5-pentafluoroethyl-1,3,4-oxadiazol-2-yl)-phenyl]-isoindole-1,3-dione,
- 4-chloro-2-[2-methyl-4-(5-heptafluoropropyl-1,3,4-oxadiazol-2-yl)-phenyl]-isoindole-1,3-dione,
- 4-chloro-2-[2-methyl-4-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl-methyl)-phenyl]-isoindole-1,3-dione,
- 4-chloro-2-[2-methyl-4-(4-trifluoromethyl-2H-1,2,3-triazol-2-yl-methyl)-phenyl]-isoindole-1,3-dione,
- 4-chloro-2-[2-methyl-4-(4-(pentafluoroethyl)-thiazol-2-yl-methyl)-phenyl]-isoindole-1,3-dione,
- 4-chloro-2-{2-methyl-4-[1-methyl-3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl-sulfanyl]-phenyl}-isoindole-1,3-dione,
- 4-chloro-2-[2-methyl-4-(5-trifluoromethyl-1,2,4-oxadiazol-3-yl)-phenyl]-isoindole-1,3-dione,
- 4-chloro-2-[2-methyl-4-(1-methyl-5-trifluoromethyl-1H-1,2,4-triazol-3-yl)-phenyl]-isoindole-1,3-dione,
- 4-iodo-2-[2-methyl-4-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl)-phenyl]-isoindole-1,3-dione and so on.
- The compounds of the formula (V), used as starting materials in the preparation process (b), are either compounds well known in the field of organic chemistry or can be synthesized according to the process described in DE-A 20 45 905, WO 01/23350.
- As their specific examples there can be mentioned ethylamine, diethylamine, n-propylamine, isopropylamine, n-butylamine, sec-butylamine, isobutylamine, t-butylamine, t-amylamine, 2-(methylthio)-ethylamine, 2-(ethylthio)-ethylamine, 1-methyl-2-(methylthio)-ethylamine, 1,1-dimethyl-2-(methylthio)-ethylamine and so on.
- The compounds of the formula (VI), used as starting materials in the preparation process (c), include publicly known compounds and can be easily prepared according to the process described in JP-A 11-240857 (1999), JPA 2001-131141, etc.
- As their specific examples there can be mentioned the following:
- N-isopropyl-phthalamic acid,
- 3-fluoro-N-isopropyl-phthalamic acid,
- 3-chloro-N-isopropyl-phthalamic acid,
- 3-bromo-N-isopropyl-phthalamic acid,
- 3-iodo-N-isopropyl-phthalamic acid,
- N-(1-methyl-2-methylsulfanyl-ethyl)-phthalamic acid,
- 3-fluoro-N-(1-methyl-2-methylsulfanyl-ethyl)-phthalamic acid,
- 3-chloro-N-(1-methyl-2-methylsulfanyl-ethyl)-phthalamic acid,
- 3-bromo-N-(1-methyl-2-methylsulfanyl-ethyl)-phthalamic acid,
- 3-iodo-N-(1-methyl-2-methylsulfanyl-ethyl)-phthalamic acid,
- N-(1,1-dimethyl-2-methylsulfanyl-ethyl)-phthalamic acid,
- N-(1,1-dimethyl-2-methylsulfanyl-ethyl)-3-fluoro-phthalamic acid,
- 3-chloro-N-(1,1-dimethyl-2-methylsulfanyl-ethyl)-phthalamic acid,
- 3-bromo-N-(1,1-dimethyl-2-methylsulfanyl-ethyl)-phthalamic acid,
- N-(1,1-dimethyl-2-methylsulfanyl-ethyl)-3-iodo-phthalamic acid,
- N-isopropyl-3-methanesulfonyloxy-phthalamic acid,
- N-(1-methyl-2-methylsulfanyl-ethyl)-3-methanesulfonyloxy-phthalamic acid,
- N-(1-methyl-2-methylsulfanyl-ethyl)-3-nitro-phthalamic acid,
- 3-chloro-N-(2-ethylsulfanyl-1-methyl-ethyl)-phthalamic acid,
- 3-bromo-N-(2-ethylsulfanyl-1-methyl-ethyl)-phthalamic acid,
- N-(2-ethylsulfanyl-1-methyl-ethyl)-3-iodo-phthalamic acid,
- N-(2-ethylsulfanyl-1-methyl-ethyl)-3-nitro-phthalamic acid,
- N-(2-ethylsulfanyl-1-methyl-ethyl)-3-methanesulfonyloxy-phthalamic acid,
- N-(1,1-dimethyl-2-methylsulfanyl-ethyl)-3-methanesulfonyloxy-phthalamic acid and so on.
- The above-mentioned compounds of the formula (VI) can be easily obtained generally by reacting phthalic anhydrides of the aforementioned formula (XII)
- wherein X has the same definition as aforementioned,
with amines of the formula -
H2N—R1 (XIII) - wherein R1 has the same definitions as aforementioned,
- The compounds of the above-mentioned formula (XIII) are well known in the field of organic chemistry and there can be specifically mentioned, for example, ethylamine, n-propylamine, isopropylamine, n-butylamine, sec-butylamine, isobutylamine, t-butylamine, t-amylamine, 2-(methylthio)ethylamine, 2-(ethylthio)ethylamine, 1-methyl-2-(methylthio)ethylamine, 1,1-dimethyl-2-(methylthio)ethylamine, etc.
- These amines can be easily obtained also by the process described in DE-A 20 45 905, WO 01/23350, etc.
- The above-mentioned reaction of the compounds of the formula (XII) with the amines of the formula (XIII) can be conducted according to the process described in, for example, J. Org. Chem., Vol. 46, p. 175 (1981) etc.
- Said reaction can be conducted in an adequate diluent, and as examples of the diluent used in that case there can be mentioned aliphatic, alicyclic and aromatic hydrocarbons (may be optionally chlorinated), for example, pentane, hexane, cyclohexane, petroleum ether, ligroine, benzene, toluene, xylene, dichloromethane, chloroform, carbon tetrachloride, 1,2-dichloroethane, chlorobenzene, dichlorobenzene, etc.; ethers, for example, ethyl ether, methyl ethyl ether, isopropyl ether, butyl ether, dioxane, dimethoxyethane (DME), tetrahydrofuran (TIM, diethylene glycol dimethyl ether (DGM), etc.; ketones, for example, acetone, methyl ethyl ketone (MEK), methyl isopropyl ketone, methyl isobutyl ketone (MIBK), etc.; nitriles, for example, acetonitrile, propionitrile, acrylonitrile, etc.; esters, for example, ethyl acetate, amyl acetate, etc.
- The above-mentioned reaction can be conducted in the presence of a base, and as said base there can be mentioned, for example, tertiary amines, dialkylaminoanilines and pyridines, for example, triethylamine, 1,1,4,4-tetramethylethylenediamine (TMEDA), N,N-dimethylaniline, N,N-diethylaniline, pyridine, 4-dimethylaminopyridine (DMAP), 1,4-diazabicyclo[2,2,2]octane (DABCO), 1,8-diazabicyclo[5,4,0]undec-7-ene (DBU), etc.
- The above-mentioned reaction can be conducted in a substantially wide range of temperature. It is adequate to conduct it at the temperatures in a range of generally from about −70 to about 100° C., preferably from about −50 to about 80° C.
- Although said reaction is conducted desirably under normal pressure, it can be operated also under elevated pressure or under reduced pressure.
- In conducting the above-mentioned reaction, the aimed compounds of the formula (VI) can be obtained, for example, by reacting 1-4 moles of the compounds of the formula (XIII) to 1 mole of the compounds of the formula (XII) in a diluent, for example, acetonitrile.
- The compounds of the formula (VII), used as starting materials in the preparation process (d), are novel compounds and can be easily obtained, for example, by reacting the compounds of the formula (VIII), starting materials in the below-mentioned preparation process (e), according to the process described in J. Med. Chem., Vol. 10, p. 982 (1967) etc. in the presence of a condensing agent.
- As specific examples of the compounds of the formula (VII), there can be mentioned the following:
- 1-[4-(4-iodo-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methyl-benzyl]-3,5-bis(trifluoromethyl)-1H-pyrazole,
- 1-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methyl-benzyl]-3,5-bis(trifluoromethyl)-1H-pyrazole,
- 1-[4-(4-iodo-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methyl-benzyl]-3,5-bis(trifluoromethyl)-1,2,4-triazole,
- 1-[4-(4-iodo-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylphenyl]-3,5-bis(trifluoromethyl)-1,1-pyrazole,
- 1-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methyl-benzyl]-3,4-bis(pentafluoroethyl)-1H-pyrazole,
- 1-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methyl-benzyl]-3,5-bis(pentafluoroethyl)-1H-pyrazole,
- 1-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methyl-benzyl]-3,4-bis(heptafluoropropyl)-1H-pyrazole,
- 1-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methyl-benzyl]-3,5-bis(heptafluoropropyl)-1H-pyrazole,
- 2-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylphenyl]-5-(trifluoromethyl)-1,3,4-oxadiazole,
- 2-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylphenyl]-5-(pentafluoroethyl)-1,3,4-oxadiazole,
- 2-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylphenyl]-5-(heptafluoropropyl)-1,3,4-oxadiazole,
- 2-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylbenzyl]-5-(trifluoromethyl)-1,3,4-oxadiazole,
- 2-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylbenzyl]-4-(trifluoromethyl)-2H-1,2,3-triazole,
- 2-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylbenzyl]-4-(pentafluoroethyl)-thiazole,
- 5-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylphenyl]sulfanyl-1-methyl-3-(trifluoromethyl)-1H-1,2,4-triazole,
- 3-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylphenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole,
- 3-[4-(4-chloro-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylphenyl]-1-methyl-5-(trifluoromethyl)-1H-1,2,4-triazole,
- 2-[4-(4-iodo-3-oxo-3H-isobenzofuran-1-ylideneamino)-3-methylphenyl]-5-(trifluoromethyl)-1,3,4-oxadiazole and so on.
- The compounds of the formula (V), similarly used as starting materials in the preparation process (d), are the same as explained in the aforementioned preparation process (b).
- The compounds of the formula (VIII), used as starting materials in the preparation process (e), are novel compounds and can be easily obtained, for example, by reacting phthalic anhydrides of the aforementioned formula (XII) with the compounds of the aforementioned formula (III).
- The above-mentioned reaction can be conducted in an adequate diluent, and as examples of the diluent used in that case there can be mentioned aliphatic, alicyclic and aromatic hydrocarbons (may be optionally chlorinated), for example, pentane, hexane, cyclohexane, petroleum ether, ligroine, benzene, toluene, xylene, dichloromethane, chloroform, carbon tetrachloride, 1,2-dichloroethane, chlorobenzene, dichlorobenzene, etc.; ethers, for example, ethyl ether, methyl ethyl ether, isopropyl ether, butyl ether, dioxane, dimethoxyethane (DME), tetrahydrofuran (THF), diethylene glycol dimethyl ether (DGM), etc.; ketones, for example, acetone, methyl ethyl ketone (MEK), methyl isopropyl ketone, methyl isobutyl ketone (MIBK), etc.; nitriles, for example, acetonitrile, propionitrile; acrylonitrile, etc.; esters, for example, ethyl acetate, amyl acetate, etc.
- The above-mentioned reaction can be conducted in the presence of a base, and as said base there can be mentioned tertiary amines, dialkylaminoanilines and pyridines, for example, triethylamine, 1,1,4,4-tetramethylethylenediamine (TMEDA), N,N-dimethylaniline, N,N-diethylaniline, pyridine, 4-dimethylaminopyridine (DMAP), 1,4-diazabicyclo[2,2,2]octane (DABCO) and 1,8-diazabicyclo[5,4,0]undec-7-ene (DBU), etc.
- The above-mentioned reaction can be conducted in a substantially wide range of temperature. It is adequate to conduct it at the temperatures in a range of generally from about −70 to about 100° C., preferably from about −50 to about 80° C.
- Although said reaction is conducted desirably under normal pressure, it can be operated also under elevated pressure or under reduced pressure.
- As specific examples of the compounds of the formula (VIII), there can be mentioned the following:
- N-{4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl-methyl]-2-methyl-phenyl}-6-iodo-phthalamic acid,
- N-{4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl-methyl]-2-methyl-phenyl}-6-chloro-phthalamic acid,
- N-{4-[3,5-bis(trifluoromethyl)-(1,2,4)-triazol-1-yl-methyl]-2-methyl-phenyl}-6-iodo-phthalamic acid,
- N-{4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-2-methyl-phenyl}-6-iodo-phthalamic acid,
- N-{4-[3,4-bis(pentafluoroethyl)-1H-pyrazol-1-yl-methyl]phenyl}-6-chloro-phthalamic acid,
- N-{4-[3,5-bis(pentafluoroethyl)-1H-pyrazol-1-yl-methyl]-phenyl}-6-chloro-phthalamic acid,
- N-{4-[3,4-bis(heptafluoropropyl)-1H-pyrazol-1-yl-methyl]-phenyl}-6-chloro-phthalamic acid,
- N-(4-[3,5-bis(heptafluoropropyl)-1H-pyrazol-1-yl-methyl]-phenyl)-6-chloro-phthalamic acid,
- N-[2-methyl-4-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl)-phenyl]-6-chloro-phthalamic acid,
- N-[2-methyl-4-(5-pentafluoroethyl-1,3,4-oxadiazol-2-yl)-phenyl]-6-chloro-phthalamic acid,
- N-[2-methyl-4-(5-heptafluoropropyl-1,3,4-oxadiazol-2-yl)-phenyl]-6-chloro-phthalamic acid,
- N-[2-methyl-4-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl-methyl)-phenyl]-6-chloro-phthalamic acid,
- N-[2-methyl-4-(4-trifluoromethyl-2H-1,2,3-triazol-2-yl-methyl)-phenyl]-6-chloro-phthalamic acid,
- N-{2-methyl-4-(4-pentafluoroethyl-thiazol-2-yl-methyl)-phenyl}-6-chloro-phthalamic acid,
- N-{2-methyl-4-[1-methyl-3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl-sufanyl]-phenyl}-6-chlorophthalamic acid,
- N-[2-methyl-4-(5-trifluoromethyl-1,2,4-oxadiazol-3-yl)-phenyl]-6-chloro-phthalamic acid,
- N-[2-methyl-4-(1-methyl-5-trifluoromethyl-1H-1,2,4-triazol-3-yl)-phenyl]-6-chloro-phthalamic acid,
- N-[2-methyl-4-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl)-phenyl]-6-iodo-phthalamic acid and so on.
- The compounds of the formula (V), similarly used as starting materials in the preparation process (e), can be the same as ones used in the aforementioned preparation processes (b) and (d).
- The compounds of the formula (If), used as starting materials in the preparation process (f), are compounds included in the formula (I) of the present invention.
- By oxidizing the group RIf in the compounds of the formula (If), namely, C1-6alkylthio-C1-6alkyl, the compounds of the formula (I), in which the group RIf corresponds to C1-6 alkylsulfinyl-C1-6alkyl or C1-6alkylsulfonyl-C1-6alkyl, can be obtained.
- The compounds of the formula (If) can be prepared by the processes of the aforementioned preparation processes (a), (b), (c), (d) and/or (e).
- As specific examples of the compounds of the formula (If), there can be mentioned the following:
- 3-iodo-N2-(1-methyl-2-methylsulfanyl-ethyl)-N1-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-phenyl}phthalamide,
- N2-(1,1-dimethyl-2-methylsulfanyl-ethyl)-3-iodo-N1-{2-methyl-4-[3,5-bis(trifluoro-methyl)-1H-pyrazol-1-ylmethyl]-phenyl}phthalamide,
- 3-iodo-N2-(1-methyl-2-methylsulfanyl-ethyl)-N1-{2-methyl-4-[3,5-bis(trifluoromethyl)-(1,2,4)-triazol-1-ylmethyl]-phenyl}phthalamide,
- 3-chloro-N2-(1-methyl-2-methylsulfanyl-ethyl)-N1-{2-methyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-phenyl}phthalamide,
- 3-chloro-N2-(1-methyl-2-methylsulfanyl-ethyl)-N1-{2-methyl-4-[3,4-bis(pentafluoro-ethyl)-1H-pyrazol-1-ylmethyl]-phenyl}phthalamide,
- 3-chloro-N2-(1-methyl-2-methylsulfanyl-ethyl)-N1-{2-methyl-4-[3,5-bis(pentafluoro-ethyl)-1H-pyrazol-1-ylmethyl]-phenyl}phthalamide,
- 3-chloro-N2-(1-methyl-2-methylsulfanyl-ethyl)-N1-{2-methyl-4-[3,4-bis(heptafluoro-propyl)-1H-pyrazol-1-ylmethyl]-phenyl}phthalamide,
- 3-chloro-N2-(1-methyl-2-methylsulfanyl-ethyl)-N1-{2-methyl-4-[3,5-bis(heptafluoro-propyl)-1H-pyrazol-1-ylmethyl]-phenyl}phthalamide and so on
- The reaction of the aforementioned preparation process (a) can be conducted in an adequate diluent singly or mixed. As examples of the diluent used in that case there can be mentioned water; aliphatic, alicyclic and aromatic hydrocarbons (may be optionally chlorinated), for example, pentane, hexane, cyclohexane, petroleum ether, ligroine, benzene, toluene, xylene, dichloromethane, chloroform, carbon tetrachloride, 1,2-dichloroethane, chlorobenzene, dichlorobenzene, etc.; ethers, for example, ethyl ether, methyl ethyl ether, isopropyl ether, butyl ether, dioxane, dimethoxyethane (DME), tetrahydrofuran (THF), diethylene glycol dimethyl ether (DGM), etc.; nitriles, for example, acetonitrile, propionitrile, acrylonitrile, etc.; esters, for example, ethyl acetate, amyl acetate, etc.
- The preparation process (a) can be conducted in the presence of an acid catalyst, and as examples of said acid catalyst there can be mentioned mineral acids, for example, hydrochloric acid and sulfuric acid; organic acids, for example, acetic acid, trifluoroacetic acid, propionic acid, methanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, etc.
- The preparation process (a) can be conducted in a substantially wide range of temperature. It is adequate to conduct it at the temperatures in a range of generally from about −20 to about 100° C., preferably from about 0 to about 100° C.
- Although said reaction is conducted desirably under normal pressure, it can be operated also under elevated pressure or under reduced pressure.
- In conducting the preparation process (a), the aimed compounds of the formula (I) can be obtained, for example, by reacting 1 to a little excess mole amount of the compounds of the formula (III) to 1 mole of the compounds of the formula (II) in a diluent, for example, 1,2-dichloroethane in the presence of 0.01-0.1 mole amount of p-toluenesulfonic acid.
- The reaction of the aforementioned preparation process (b) can be conducted in an adequate diluent. As examples of the diluent used in that case there can be mentioned aliphatic, alicyclic and aromatic hydrocarbons (may be optionally chlorinated), for example, pentane, hexane, cyclohexane, petroleum ether, ligroine, benzene, toluene, xylene, dichloromethane, chloroform, carbon tetrachloride, 1,2-dichloroethane, chlorobenzene, dichlorobenzene, etc.; ethers, for example, ethyl ether, methyl ethyl ether, isopropyl ether, butyl ether, dioxane, dimethoxyethane (DME), tetrahydrofuran (Tiff), diethylene glycol dimethyl ether (DGM), etc.; esters, for example, ethyl acetate, amyl acetate, etc.; acid amides, for example, dimethylformamide (DMF), dimethylacetamide (DMA), N-methylpyrrolidone, 1,3-dimethyl-2-imidazolidinone, hexamethyl phosphoric triamide (HMPA), etc.
- The preparation process (b) can be conducted in the presence of an acid catalyst and as examples of said acid catalyst there can be mentioned mineral acids, for example, hydrochloric acid and sulfuric acid; organic acids, for example, acetic acid, trifluoroacetic acid, propionic acid, methanesulfonic acid, p-toluenesulfonic acid, etc.
- The preparation process (b) can be conducted in a substantially wide range of temperature. It is adequate to conduct it at the temperatures in a range of generally from about −20 to about 150° C., preferably from room temperature (20° C.) to about 100° C.
- Although said reaction is conducted desirably under normal pressure, it can be operated also under elevated pressure or under reduced pressure.
- In conducting the preparation process (b), the aimed compounds of the formula (I) can be obtained, for example, by reacting 1-25 moles of the compounds of the formula (V) to 1 mole of the compounds of the formula (IV) in a diluent, for example, dioxane in the presence of 0.01-0.5 mole amount of acetic acid.
- The aforementioned preparation processes (c), (d) and (e) can be conducted under the similar condition as the above-mentioned preparation process (a).
- The reaction of the aforementioned preparation process (f) can be conducted in an adequate diluent. As examples of the diluent used in that case there can be mentioned aliphatic, alicyclic and aromatic hydrocarbons (may be optionally chlorinated), for example, benzene, toluene, xylene, dichloromethane, chloroform, carbon tetrachloride, 1,2-dichloroethane, chlorobenzene, dichlorobenzene, etc.; alcohols, for example, methanol, ethanol, isopropanol and butanol; acids; formic acid, acetic acid, etc.
- As the oxidizing agents usable in the aforementioned preparation process (f) there can be mentioned, for example, m-chloroperbenzoic acid, peracetic acid, potassium metaperiodate, potassium hydrogen persulfate (oxon), hydrogen peroxide, etc.
- The preparation process (f) can be conducted in a substantially wide range of temperature. It is adequate to conduct it at the temperatures in a range of generally from about −50 to about 150° C., preferably from about −10 to about 100° C.
- Although said reaction is conducted desirably under normal pressure, it can be operated also under elevated pressure or under reduced pressure.
- In conducting the preparation process (f), the aimed compounds of the corresponding formula (I) can be obtained, for example, by reacting 1-5 moles of an oxidizing agent to 1 mole of the compounds of the formula (If) in a diluent, for example, dichloromethane.
- The reaction of the aforementioned preparation process (f) can be conducted, for example, according to the process described in JIKKEN KAGAKU KOZA (Lecture on experimental chemistry) edited by the Chemical Society of Japan, 4th ed., Vol. 24, p. 350 (1992) published by MARUZEN or ibid. p. 365.
- The compounds of the formula (I) of the present invention show strong insecticidal action. The compounds of the formula (I), according to the present invention can, therefore, be used as insecticidal agents. And the active compounds of the formula (I) of the present invention exhibit exact controlling effect against harmful insects without giving phytotoxicity on cultured plants. And the compounds of the present invention can be used for controlling a wide variety of pests, for example, harmful sucking insects, biting insects and other plant-parasitic pests, stored grain pests, hygienic pests, etc. and applied for their extermination.
- As examples of such pests there can be mentioned the following pests:
- As insects, there can be mentioned:
- Coleoptera pests, for example, Callosobruchus Chinensis, Sitophilus zeamais, Tribolium castaneum, Epilachna vigintioctomaculata, Agriotes fuscicollis, Anomala rufocuprea, Leptinotarsa decemlineata, Diabrotica spp., Monochamus alternatus, Lissorhoptrus oryzophilus, Lyctus bruneus;
- Lepidoptera pests, for example,
- Lymantria dispar, Malacosoma neustria, Pieris rapae, Spodoptera litura, Mamestra brassicae, Chilo suppressalis, Pyrausta nubilalis, Ephestia cautella, Adoxophyes orana, Carpocapsa pomonella, Agrotis fucosa, Galleria mellonella, Plutella maculipennis, Heliothis virescens, Phyllocnistis citrella;
- Hemiptera pests, for example,
- Nephotettix cincticeps, Nilaparvata lugens, Pseudococcus comstocki, Unaspis yanonensis, Myzus persicae, Aphis pomi, Aphis gossypii, Rhopalosiphum pseudobrassicas, Stephanitis nashi, Nazara spp., Trialeurodes vaporariorum, Psylla spp.;
- Thysanoptera pests, for example,
- Thrips palmi, Frankliniella occidental;
- Orthoptera pests, for example,
- Blatella gennanica, Periplaneta americana, Gryllotalpa africana, Locusta migratoria migratoriodes;
- Homoptera pests, for example,
- Reticulitermes speratus, Coptotennes formosanus;
- Diptera pests, for example,
- Musca domestica, Aedes aegypti, Hylemia platura, Culex pipiens, Anopheles slnensis, Culex tritaeniorlzynchus, Liriomyzae trifolii etc.
- Moreover, as mites there can be mentioned, for example,
- Tetranychus cinnabarinus, Tetranychus urticae, Panonychus citri, Aculops pelekassi, Tarsonemus spp., etc.
- Furthermore, as nematodes there can be mentioned, for example,
- Meloidogyne incognita, Bursaphelenchus lignicolus Mamiya et Kiyohara, Aphelenchoides besseyi, Heterodera glycines, Pratylenchus spp., etc.
- In addition, in the field of veterinary medicine, the novel compounds of the present invention can be effectively used against various harmful animal-parasitic pests (endoparasites and ectoparasites), for example, insects and helminthes. As examples of such animal-parasitic pests there can be mentioned the following pests:
- As insects there can be mentioned, for example,
- Gastrophilus spp., Stomoxys spp., Trichodectes spp., Rhodnius spp., Ctenocephalides canis, Cimex lectularius etc.
- As mites there can be mentioned, for example,
- Ornithodoros spp., Ixodes spp., Boophilus spp., etc.
- In the present invention, substances having insecticidal action against pests, which include all of them, are in some cases called as insecticides.
- All plants and plant parts can be treated in accordance with the invention. Plants are to be understood as meaning in the present context all plants and plant populations such as desired and undesired wild plants or crop plants (including naturally occurring crop plants). Crop plants can be plants which can be obtained by conventional plant breeding and optimization methods or by biotechnological and genetic engineering methods or by combinations of these methods, including the transgenic plants and including the plant cultivars protectable or not protectable by plant breeders' rights. Plant parts are to be understood as meaning all parts and organs of plants above and below the ground, such as shoot, leaf, flower and root, examples which may be mentioned being leaves, needles, stalks, stems, flowers, fruit bodies, fruits, seeds, roots, tubers and rhizomes. The plant parts also include harvested material, and vegetative and generative propagation material, for example cuttings, tubers, rhizomes, offshoots and seeds.
- Treatment according to the invention of the plants and plant parts with the active compounds is carried out directly or by allowing the compounds to act on the surroundings, environment or storage space by the customary treatment methods, for example by immersion, spraying, evaporation, fogging, scattering, painting on and, in the case of propagation material, in particular in the case of seeds, also by applying one or more coats.
- The active compounds, according to the present invention, can be converted into the customary formulation forms, when they are used as insecticides. As formulation forms there can be mentioned, for example, solutions, emulsions, wettable powders, water dispersible granules, suspensions, powders, foams, pastes, tablets, granules, aerosols, natural and synthetic materials impregnated with active compound, microcapsules, seed coating agents, formulations used with burning equipment (as burning equipment, for example, fumigation and smoking cartridges, cans, coils, etc.), ULV [cold mist, warm mist], etc.
- These formulations can be produced according to per se known methods, for example, by mixing the active compounds with extenders, namely liquid diluents or carriers; liquefied gas diluents or carriers; solid diluents or carriers, and optionally with surface-active agents, namely emulsifiers and/or dispersants and/or foam-forming agents.
- In case that water is used as extender, for example, organic solvents can also be used as auxiliary solvents.
- As liquid diluents or carriers there can be mentioned, for example, aromatic hydrocarbons (for example, xylene, toluene, alkylnaphthalene, etc.), chlorinated aromatic or chlorinated aliphatic hydrocarbons (for example, chlorobenzenes, ethylene chlorides, methylene chloride, etc.), aliphatic hydrocarbons [for example, cyclohexane etc. or paraffins (for example, mineral oil fractions etc.)], alcohols (for example, butanol, glycols and their ethers, esters, etc.), ketones (for example, acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone, etc.), strongly polar solvents (for example, dimethylformamide, dimethyl sulfoxide, etc.), and water.
- Liquefied gas diluents or carriers are substances that are gases at normal temperature and pressure and there can be mentioned, for example, aerosol propellants such as butane, propane, nitrogen gas, carbon dioxide, halogenated hydrocarbons.
- As solid diluents there can be mentioned, for example, ground natural minerals (for example, kaolin, clay, talc, chalk, quartz, attapulgite, montmorillonite, diatomaceous earth, etc.), ground synthetic minerals (for example, highly dispersed silicic acid, alumina, silicates, etc.).
- As solid carriers for granules there can be mentioned, for example, crushed and fractionated rocks (for example, calcite, marble, pumice, sepiolite, dolomite, etc.), synthetic granules of inorganic or organic meals, particles of organic materials (for example, saw dust, coconut shells, maize cobs, tobacco stalks, etc.), etc.
- As emulsifiers and/or foam-forming agents, there can be mentioned, for example, nonionic and anionic emulsifiers [for example, polyoxyethylene fatty acid esters, polyoxyethylene fatty acid alcohol ethers (for example, alkylaryl polyglycol ethers), alkylsulfonates, alkylsulfates, arylsulfonates, etc.], albumin hydrolysis products, etc.
- Dispersants include, for example, lignin sulfite waste liquor and methyl cellulose.
- Tackifiers can also be used in formulations (powders, granules, emulsifiable concentrates). As said tackifiers, there can be mentioned, for example, carboxymethyl cellulose, natural or synthetic polymers (for example, gum Arabic, polyvinyl alcohol, polyvinyl acetate, etc.).
- Colorants can also be used. As said colorants there can be mentioned, for example, inorganic pigments (for example, iron oxide, titanium oxide, Prussian Blue, etc,), organic dyestuffs such as alizarin dyestuffs, azo dyestuffs or metal phthalocyanine dyestuffs, and further trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.
- Said formulations can contain the aforementioned active component of the amount in the range of generally 0.1-95% by weight, preferably 0.5-90% by weight.
- The active compounds of the formula (I) of the present invention can exist also as a mixed agent with other active compounds, for example, insecticides, poisonous baits, bactericides, miticides, nematicides, fungicides, growth regulators or herbicides in the form of their commercially useful formulations and in the application forms prepared from such formulations. Here, as the above-mentioned insecticides, there can be mentioned, for example, organophosphorous agents, carbamate agents, carboxylate type chemicals, chlorinated hydrocarbon type chemicals, insecticidal substances produced by microorganisms, etc.
- Further, the active compounds of the formula (I) of the present invention can exist also as a mixed agent with a synergist, and such formulations and application forms can be mentioned as commercially useful. Said synergist itself must not be active, but is a compound that enhances the action of the active compound.
- Particularly favourable mixing components are, for example, the following compounds:
- 2-phenylphenol; 8-hydroxyquinoline sulfate; acibenzolar-S-methyl; aldimorph; amidoflumet; ampropylfos; ampropylfos-potassium; andoprim; anilazine; azaconazole; azoxystrobin; benalaxyl; benalaxyl-M; benodanil; benomyl; benthiavalicarb-isopropyl; benzamacril; benzamacril-isobutyl; bilanafos; binapacryl; biphenyl; bitertanol; blasticidin-S; boscalid; bromuconazole; bupirimate; buthiobate; butylamine; calcium polysulfide; capsimycin; captafol; captan; carbendazim; carboxin; carpropamid; carvone; chinomethionat; chlobenthiazone; chlorfenazole; chloroneb; chlorothalonil; chlozolinate; clozylacon; cyazofamid; cyflufenamid; cymoxanil; cyproconazole; cyprodinil; cyprofuram; Dagger G; debacarb; dichlofluanid; dichlone; dichlorophen; diclocymet; diclomezine; dicloran; diethofencarb; difenoconazole; diflumetorim; dimethirimol; dimethomorph; dimoxystrobin; diniconazole; diniconazole-M; dinocap; diphenylamine; dipyrithione; ditalimfos; dithianon; dodine; drazoxolon; edifenphos; epoxiconazole; ethaboxam; ethirimol; etridiazole; famoxadone; fenamidone; fenapanil; fenarimol; fenbuconazole; fenfuram; fenhexamid; fenitropan; fenoxanil; fenpiclonil; fenpropidin; fenpropimorph; ferbam; fluazinam; flubenzimine; fludioxonil; flumetover, flumorph; fluoromide; fluoxastrobin; fluquinconazole; flurprimidol; flusilazole; flusulfamide; flutolanil; flutriafol; folpet; fosetyl-A1; fosetyl-sodium; fuberidazole; furalaxyl; furametpyr; furcarbanil; furmecyclox; guazatine; hexachlorobenzene; hexaconazole; hymexazol; imazalil; imibenconazole; iminoctadine triacetate; iminoctadine tris(albesilate); iodocarb; ipconazole; iprobenfos; iprodione; iprovalicarb; irumamycin; isoprothiolane; isovaledione; kasugamycin; kresoxim-methyl; mancozeb; maneb; meferimzone; mepanipyrim; mepronil; metalaxyl; metalaxyl-M; metconazole; methasulfocarb; methfuroxam; metiram; metominostrobin; metsulfovax; mildiomycin; myclobutanil; myclozolin; natamycin; nicobifen; nitrothal-isopropyl; noviflumuron; nuarimol; ofurace; orysastrobin; oxadixyl; oxolinic acid; oxpoconazole; oxycarboxin; oxyfenthiin; paclobutrazol; pefurazoate; penconazole; pencycuron; phosdiphen; phthalide; picoxystrobin; piperalin; polyoxins; polyoxorim; probenazole; prochloraz; procymidone; propamocarb; propanosine-sodium; propiconazole; propineb; proquinazid; prothioconazole; pyraclostrobin; pyrazophos; pyrifenox; pyrimethanil; pyroquilon; pyroxyfur; pyrrolnitrin; quinconazole; quinoxyfen; quintozene; simeconazole; spiroxamine; sulfur; tebuconazole; tecloftalam; tecnazene; tetcyclacis; tetraconazole; thiabendazole; thicyofen; thifluzamide; thiophanate-methyl; thiram; tioxymid; tolclofos-methyl; tolylfluanid; triadimefon; triadimenol; triazbutil; triazoxide; tricyclamide; tricyclazole; tridemorph; trifloxystrobin; triflumizole; triforine; triticonazole; uniconazole; validamycin A; vinclozolin; zineb; ziram; zoxamide; (2S)-N-[2-[4-[[3-(4-chlorophenyl)-2-propynyl]oxy]-3-methoxyphenyl]ethyl]-3-methyl-2-[(methylsulfonyl)amino]-butanamide; 1-(1-naphthalenyl)-1H-pyrrol-2,5-dione; 2,3,5,6-tetrachloro-4-(methylsulfonyl)-pyridine; 2-amino-4-methyl-N-phenyl-5-thiazolecarboxamide; 2-chloro-N-(2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl)-3-pyridinecarboxamide; 3,4,5-trichloro-2,6-pyridinedicarbonitrile; actinovate; cis-1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)-cycloheptanol; methyl 1-(2,3-dihydro-2,2-dimethyl-1H-inden-1-yl)-1H-imidazole-5-carboxylate; mono potassium carbonate; N-(6-methoxy-3-pyridinyl)-cyclopropane carboxamide; N-butyl-8-(1,1-dimethylethyl)-1-oxaspiro[4.5]decan-3-amine; sodium tetrathiocarbonate; and copper salts and preparations, such as Bordeaux mixture; copper hydroxide; copper naphthenate; copper oxychloride; copper sulphate; cufraneb; copper oxide; mancopper; oxine-copper.
- bronopol, dichlorophen, nitrapyrin, nickel dimethyldithiocarbamate, kasugamycin, octhilinone, furancarboxylic acid, oxytetracyclin, probenazole, streptomycin, tecloftalam, copper sulphate and other copper preparations.
- 1. Acetylcholinesterase (AChE) inhibitors
- 1.1 Carbamates (e.g. alanycarb, aldicarb, aldoxycarb, allyxycarb, aminocarb, azamethiphos, bendiocarb, benfuracarb, bufencarb, butacarb, butocarboxim, butoxycarboxim, carbaryl, carbofuran, carbosulfan, chloethocarb, coumaphos, cyanofenphos, cyanophos, dimetilan, ethiofencarb, fenobucarb, fenothiocarb, formetanate, furathiocarb, isoprocarb, metam-sodium, methiocarb, methomyl, metolcarb, oxamyl, pirimicarb, promecarb, propoxur, thiodicarb, thiofanox, triazamate, trimethacarb, XMC, xylylcarb)
- 1.2 Organophosphates (e.g. acephate, azamethiphos, azinphos (-methyl, -ethyl), bromophos-ethyl, bromfenvinfos (-methyl), butathiofos, cadusafos, carbophenothion, chlorethoxyfos, chlorfenvinphos, chlormephos, chlorpyrifos (-methyl/-ethyl), coumaphos, cyanofenphos, cyanophos, chlorfenvinphos, demeton-s-methyl, demeton-s-methylsulphon, dialifos, diazinon, dichlofenthion, dichloriros/ddvp, dicrotophos, dimethoate, dimethylvinphos, dioxabenzofos, disulfoton, epn, ethion, ethoprophos, etrimfos, famphur, fenamiphos, fenitrothion, fensulfothion, fenthion, flupyrazofos, fonofos, formothion, fosmethilan, fosthiazate, heptenophos, iodofenphos, iprobenfos, isazofos, isofenphos, isopropyl o-salicylate, isoxatbion, malathion, mecarbam, methacrifos, methamidophos, methidathion, mevinphos, monocrotophos, naled, omethoate, oxydemeton-methyl, parathion (-methyl/-ethyl), phenthoate, phorate, phosalone, phosmet, phosphamidon, phosphocarb, phoxim, pirimiphos (-methyl/-ethyl), profenofos, propaphos, propetamphos, prothiofos, prothoate, pyraclofos, pyridaphenthion, pyridathion, quinalphos, sebufos, sulfotep, sulprofos, tebupirimfos, temephos, terbufos, tetrachlorvinphos, thiometon, triazophos, triclorfon, vamidothion)
- 2. Sodium channel modulators/voltage dependant sodium channel blockers
- 2.1 Pyrethroids (e.g. acrinathrin, allethrin (d-cis-trans, d-trans), beta-cyflutbrin, bifenthrin, bioallethrin, bioallethrin-s-cyclopentyl-isomer, bioethanometbrin, biopermethrin, bioresmethrin, chlovaporthrin, cis-cypermethrin, cis-resmethrin, cis-permethrin, clocythrin, cycloprothrin, cyfluthrin, cyhalothrin, cypermethrin (alpha-, beta-, theta-, zeta), cyphenothrin, DDT, deltamethrin, empenthrin (1R-isomer), esfenvalerate, etofenprox, fenfluthrin, fenpropathrin, fenpyrithrin, fenvalerate, flubrocythrinate, flucythrinate, flufenprox, flumetbrin, fluvalinate, fubfenprox, gamma-cyhalothrin, imiprothrin, kadethrin, lambda-cyhalothrin, metofluthrin, permethrin (cis-, trans), phenothrin (1R-trans isomer), prallethrin, proflutbrin, protrifenbute, pyresmethrin, resmethrin, RU 15525, silafluofen, tau-fluvalinate, tefluthrin, terallethrin, tetramethrin (1R-isomer), tralomethrin, transfluthrin, ZXI 8901, pyrethrins (pyrethrum))
- 2.2 Oxadiazine (e.g. indoxacarb)
- 3. Acetylcholine receptor agonists/-antagonists
- 3.1 Chloronicotinyls/neonicotinoids (e.g. acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, nithiazine, thiacloprid, thiamethoxam)
- 3.2 nicotine, bensultap, cartap
- 4. Acetylcholine receptor modulators
- 4.1 Spinosyns (e.g. spinosad)
- 5. GABA gated chloride channel antagonists
- 5.1 Cyclodiene organochlorines (e.g. camphechlor, chlordane, endosulfan, gamma HCH, HCH, heptachlor, lindane, methoxychlor
- 5.2 Fiproles (e.g. acetoprole, ethiprole, fipronil, vaniliprole)
- 6. Chloride channel activators
- 6.1 Mectins (e.g. abaraectin, avermectin, emamectin, emamectin-benzoate, ivermectin, milbemectin, milbemycin)
- 7. Juvenile hormone mimics
- (e.g. diofenolan, epofenonane, fenoxycarb, hydroprene, kinoprene, methoprene, pyriproxifen, triprene)
- 8. Ecdysone agonists/disruptors
- 8.1 Diacylhydrazines (e.g. chromafenozide, halofenozide, methoxyfenozide, tebufenozide)
- 9. Inhibitors of chitin biosynthesis
- 9.1 Benzoylureas (e.g. bistrifluoron, chlofluazuron, diflubenzuron, fluazuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, penfluoron, teflubenzuron, tifiumuron)
- 9.2 buprofezin
- 9.3 cyromazine
- 10. Inhibitors of oxidative phosphorylation, ATP-disruptors
- 10.1 diafenthiuron
- 10.2 Organotins (e.g. azocyclotin, cyhexatin, fenbutatin-oxide)
- 11. Decoupler of oxidative phoshorylation by diruption of H proton gradient
- 11.1 Pyrroles (e.g. chlorfenapyr)
- 11.2 Dinitrophenoles (e.g. binapacyrl, dinobuton, dinocap, DNOC)
- 12. Site I electron transport inhibitors
- 12.1 METT's (e.g. fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad)
- 12.2 hydramethyhione
- 12.3 dicofol
- 13. Site II electron transport inhibitors
- 13.1 rotenone
- 14. Site II electron transport inhibitors
- 14.1 acequinocyl, fluacrypyrim
- 15. Microbial disruptors of insect midgut membranes
- Bacillus thuringiensis strains
- 16. Inhibitors of lipid synthesis
- 16.1 Tetronic acid insecticides (e.g. spirodiclofen, spiromesifen)
- 16.2 Tetramic acid insecticides [e.g. 3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4.5]dec-3-en-4-yl ethyl carbonate (alias: carbonic acid, 3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4.5]-dec-3-en-4-yl ethyl ester, CAS-Reg.-No.: 382608-10-8) and carbonic acid, cis-3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4.5]dec-3-en-4-yl ethyl ester (CAS-Reg.-No.: 203313-25-1)]
- 17. Carboxamides
- (e.g. flonicamid)
- 18. Octopaminergic agonists
- (e.g. amitraz)
- 19. Inhibitors of magnesium stimulated ATPase
- (e.g. propargite)
- 20. Phthalamides
- (e.g. N2-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N1-[2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]-1,2-benzenedicarboxamide (CAS-Reg.-No.: 272451-65-7, flubendiamide))
- 21. Nereistoxin analogues
- (e.g. thiocyclam hydrogen oxalate, thiosultap-sodium)
- 22. Biologica, hormones or pheromones
- (e.g. azadirachtin, Bacillus spec., Beauveria spec., codlemone, Metarrhizium spec., Paecilomyces spec., thuringiensin, Verticillium spec.)
- 23. Compounds of unknown or non-specific mode of action
- 23.1 Fumigants (e.g. aluminium phosphide, methyl bromide, sulfa yl fluoride)
- 23.2 Selective feeding blockers (e.g. cryolite, flonicamid, pymetrozine)
- 23.3 Mite growth inhibitors (e.g. clofentezine, etoxazole, hexythiazox)
- 23.4 amidoflumet, benclothiaz, benzoximate, bifenazate, bromopropylate, buprofezin, chinomethionat, chlordimeform, chlorobenzilate, chloropicrin, clothiazoben, cycloprene, cyflumetofen, dicyclanil, fenoxacrim, fentrifanil, flubenzimine, flufenerim, flutenzin, gossyplure, hydramethylnone, japonilure, metoxadiazone, petroleum, piperonyl butoxide, potassium oleate, pyrafluprole, pyridalyl, pyriprole, sulfluramid, tetradifon, tetrasul, triarathene, verbutin
- further the compound 3-methyl-phenyl-propylcarbamate (Tsumacide Z), the compound 3-(5-chloro-3-pyridinyl)-8-(2,2,2-trifluoroethyl)-8-azabicyclo[3.2.1]octan-3-carbonitrile (CAS-Reg.-Nr. 185982-80-3) and the corresponding 3-endo isomer (CAS-Reg.-Nr. 185984-60-5) (cf. WO 96/37494, WO 98/25923), and preparations comprising insecticidal active plant extracts, nematodes, fungi or viruses.
- A mixture with other known active compounds, such as herbicides, fertilizers, growth regulators, safeners and/or semiochemicals is also possible.
- When used as insecticides, the active compounds according to the invention can furthermore be present in their commercially available formulations and in the use forms, prepared from these formulations, as a mixture with synergistic agents. Synergistic agents are compounds, which increase the action of the active compounds, without it being necessary for the synergistic agent added to be active itself.
- When used as insecticides, the active compounds according to the invention can furthermore be present in their commercially available formulations and in the use forms, prepared from these formulations, as a mixture with inhibitors which reduce degradation of the active compound after use in the vicinity of the plant, on the surface of parts of plants or in plant tissues.
- The content of the active compounds of the formula (I) of the present invention in a commercially useful application form can be varied in a wide range.
- The concentration of the active compounds of the formula (I) of the present invention at the time of actual usage can be, for example, in the range of 0.0000001-100% by weight, preferably 0.00001-1% by weight.
- The compounds of the formula (I) of the present invention can be applied by usual methods suitable to the application forms.
- In case of application against hygiene pests and pests of stored products, the active compounds of the present invention have a good stability against alkali on limed substrates and further show an excellent residual effectiveness on wood and soil.
- As already mentioned above, it is possible to treat all plants and their parts according to the invention. In a preferred embodiment, wild plant species and plant cultivars, or those obtained by conventional biological breeding methods, such as crossing or protoplast fusion, and parts thereof, are treated. In a further preferred embodiment, transgenic plants and plant cultivars obtained by genetic engineering, if appropriate in combination with conventional methods (Genetically Modified Organisms), and parts thereof are treated. The term “parts” or “parts of plants” or “plant parts” has been explained above.
- Particularly preferably, plants of the plant cultivars which are in each case commercially available or in use are treated according to the invention. Plant cultivars are to be understood as meaning plants having certain properties (“traits”) which have been obtained by conventional breeding, by mutagenesis or by recombinant DNA techniques. These can be cultivars, bio- or genotypes.
- Depending on the plant species or plant cultivars, their location and growth conditions (soils, climate, vegetation period, diet), the treatment according to the invention may also result in superadditive (“synergistic”) effects. Thus, for example, reduced application rates and/or a widening of the activity spectrum and/or an increase in the activity of the substances and compositions to be used according to the invention, better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, increased flowering performance, easier harvesting, accelerated maturation, higher harvest yields, better quality and/or a higher nutritional value of the harvested products, better storage stability and/or processability of the harvested products are possible which exceed the effects which were actually to be expected.
- The transgenic plants or plant cultivars (i.e. those obtained by genetic engineering) which are preferably to be treated according to the invention include all plants which, in the genetic modification, received genetic material which imparted particularly advantageous useful traits to these plants. Examples of such traits are better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, increased flowering performance, easier harvesting, accelerated maturation, higher harvest yields, better quality and/or a higher nutritional value of the harvested products, better storage stability and/or processability of the harvested products. Further and particularly emphasized examples of such traits are a better defence of the plants against animal and microbial pests, such as against insects, mites, phytopathogenic fungi, bacteria and/or viruses, and also increased tolerance of the plants to certain herbicidally active compounds. Examples of transgenic plants which may be mentioned are the important crop plants, such as cereals (wheat, rice), maize, soya beans, potatoes, cotton, tobacco, oilseed rape and also fruit plants (with the fruits apples, pears, citrus fruits and grapes), and particular emphasis is given to maize, soya beans, potatoes, cotton, tobacco and oilseed rape. Traits that are emphasized are in particular increased defence of the plants against insects, arachnids, nematodes and worms by toxins formed in the plants, in particular those formed in the plants by the genetic material from Bacillus thuringiensis (for example by the genes CryIA(a), CryIA(b), CryIA(c), CryIIA, CryIIIA, CryIIIB2, Cry9c, Cry2Ab, Cry3Bb and CryIF and also combinations thereof) (hereinbelow referred to as “Bt plants”). Traits that are also particularly emphasized are the increased defence of the plants against fungi, bacteria and viruses by systemic acquired resistance (SAR), systemin, phytoalexius, elicitors and resistance genes and correspondingly expressed proteins and toxins. Traits that are furthermore particularly emphasized are the increased tolerance of the plants to certain herbicidally active compounds, for example imidazolinones, sulphonylureas, glyphosate or phosphinotricin (for example the “PAT” gene). The genes which impart the desired traits in question can also be present in combination with one another in the transgenic plants. Examples of “Bt plants” which may be mentioned are maize varieties, cotton varieties, soya bean varieties and potato varieties which are sold under the trade names YIELD GARD® (for example maize, cotton, soya beans), KnockOut® (for example maize), StarLink® (for example maize), Bollgard® (cotton), Nucotn® (cotton) and NewLeaf® (potato). Examples of herbicide-tolerant plants which may be mentioned are maize varieties, cotton varieties and soya bean varieties which are sold under the trade names Roundup Ready® (tolerance to glyphosate, for example maize, cotton, soya bean), Liberty Link® (tolerance to phosphinotricin, for example oilseed rape), IMI® (tolerance to imidazolinones) and STS® (tolerance to sulphonylureas, for example maize). Herbicide-resistant plants (plants bred in a conventional manner for herbicide tolerance) which may be mentioned include the varieties sold under the name Clearfield® (for example maize). Of course, these statements also apply to plant cultivars having these genetic traits or genetic traits still to be developed, which plants will be developed and/or marketed in the future.
- The plants listed can be treated according to the invention in a particularly advantageous manner with the compounds of the general formula I and/or the active compound mixtures according to the invention. The preferred ranges stated above for the active compounds or mixtures also apply to the treatment of these plants. Particular emphasis is given to the treatment of plants with the compounds or mixtures specifically mentioned in the present text.
- Then the present invention will be described more specifically by examples. The present invention, however, should not be restricted only to them in any way.
-
- 3-(1,1-Dimethyl-2-methylsulfanyl-ethylimino)-4-iodo-3H-isobenzofuran-1-one (0.53 g) and 1-(3-methyl-4-aminobenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole (0.45 g) were dissolved in acetonitrile (15 ml), to which p-toluenesulfonic acid monohydrate (0.01 g) was added and the mixture was stirred at 60° C. for 3 hours. After finishing the reaction, the solvent was distilled off under reduced pressure and the residue was purified by silica gel column chromatography to obtaining N1-[4-(3,5-bistrifluoromethylpyrazol-1-ylmethyl)-2-methylphenyl]-N2-(1,1-dimethyl-2-methylsulfanylethyl)-3-iodophthalamide (0.91 g). mp. 83-87° C.
-
- N1-{4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-2-methylphenyl}-N2-(1,1-dimethyl-2-methylsulfanylethyl)-3-iodophthalamide (0.5 g) was dissolved in dichloromethane, to which m-chloroperbenzoic acid (0.26 g) was added and the mixture was stirred for 5 hours under ice cooling. After finishing the reaction, the mixture was washed successively with aqueous solution of sodium thiosulfate, saturated aqueous solution of sodium bicarbonate and saturated aqueous solution of sodium chloride, and dried with anhydrous magnesium sulfate. After distilling off the solvent, the obtained residue was purified by silica gel column chromatography to obtain N1-{4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-2-methylphenyl}-N2-(2-methanesulfinyl-1,1-dimethylethyl)-3-iodophthalamide (0.30 g).
- 1H-NMR (CDCl3, ppm): 1.57 (3H, s), 1.60 (3H, s), 2.20 (3H, s), 2.30 (3H, s), 2.93 (2H, dd), 5.43 (2H, s), 6.57 (1H, s), 6.90 (1H, s), 7.0-8.2 (7H, m).
-
- N1-{4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-2-methylphenyl}-N2-(1,1-dimethyl-2-methylsulfanylethyl)-3-iodophthalamide (0.30 g) was dissolved in dichloromethane, to which m-chloroperbenzoic acid (0.26 g) was added and the mixture was stirred at room temperature for 5 hours. After finishing the reaction, the mixture was washed successively with aqueous solution of sodium thiosulfate, saturated aqueous solution of sodium bicarbonate and saturated aqueous solution of sodium chloride, and dried with anhydrous magnesium sulfate. After distilling off the solvent, the obtained crude crystals were washed with petroleum ether to obtain N1-{4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-2-methylphenyl}-3-iodo-N2-(2-methanesulfonyl-1,1-dimethylethyl)phthalamide (0.25 g). mp. 104-107° C.
-
- A dioxane solution (15 ml) of 2-{4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-2-methylphenyl}-4-fluoroisoindole-1,3-dione (0.94 g), (S)-1-methyl-2-methylsulfanylethylamine (0.63 g) and acetic acid (0.12 g) was refluxed for 18 hours. After cooling to room temperature, the solvent was distilled off and the obtained residue was purified by silica gel column chromatography to obtain N1-{4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-2-methylphenyl}-3-fluoro-N2-[1-(S)-1-methyl-2-methylsulfanyl-ethyl]-phthalamide (0.19 g) (compound No. 549). mp. 66-68° C.
-
- 3-Iodo-N-(1,1-dimethyl-2-methylsulfanyl-ethyl)-phthalamic acid (0.39 g) and N-(3-dimethylaminopropyl)-N1-ethylcarbonyl diimidazole hydrochloride (0.19 g) were stirred in dichloromethane (10 ml) at room temperature for 30 minutes. Then, 2-methyl-4-[1-(3-trifluoromethyl-1H-pyrazol-1-yl)-ethyl]-aniline (0.30 g) and p-toluenesulphonic acid monohydrate (0.02 g) were added thereto and the mixture was stirred at room temperature for 3 hours. After distilling off the solvent under reduced pressure, the obtained residue was purified by silica gel column chromatography to obtain N2-(1,1-dimethyl-2-methylsulfanyl-ethyl)-3-iodo-N1-{2-methyl-4-[1-(3-trifluoromethyl-1H-pyrazol-1-yl)-ethyl]-phenyl}-phthalamide (0.38 g) (compound No. 558). mp. 79-86° C.
- The compounds of the formula (I), according to the present invention, which can be obtained in the Same manner as the above-mentioned Synthesis Examples 1 to 5 are shown in Table 1, together with the compounds obtained in the above-mentioned Synthesis Examples 1 to 5.
- NMR data of the compounds, whose mp. column is marked as ***, are collectively shown in Table 2, separately from Table 1.
-
TABLE 1 No. R1 X Y A m Q R2 R3 R4 mp 1 C(CH3)2CH2SCH3 3-H 2-CH3 CH2 1 Q1 CF3 CF3 H *** 2 C(CH3)2CH2SOCH3 3-H 2-CH3 CH2 1 Q1 CF3 CF3 H 3 C(CH3)2CH2SO2CH3 3-H 2-CH3 CH2 1 Q1 CF3 CF3 H *** 4 CH(CH3)CH2SCH3 3-H 2-CH3 CH2 1 Q1 CF3 CF3 H 5 CH(CH3)CH2SOCH3 3-H 2-CH3 CH2 1 Q1 CF3 CF3 H 6 CH(CH3)CH2SO2CH3 3-H 2-CH3 CH2 1 Q1 CF3 CF3 H 7 CH(CH3)2 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H 8 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H *** 9 C(CH3)2CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H 80-84 10 C(CH3)2CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H 183-186 11 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H *** 12 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H 76-81 (S)-isomer 13 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H 185-193 14 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H 192-194 (S)-isomer 15 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H *** 16 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H 88-93 (S)-isomer 17 CH(CH3)CH2SC2H5 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H (S)-isomer 18 CH(CH3)CH2SOC2H5 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H (S)-isomer 19 CH(CH3)CH2SO2C2H5 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H (S)-isomer 20 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 OCHF2 H 21 C(CH3)2CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 OCHF2 H 22 C(CH3)2CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 CF3 OCHF2 H 23 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 OCHF2 H 24 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 OCHF2 H (S)-isomer 25 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 OCHF2 H 26 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 OCHF2 H (S)-isomer 27 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 CF3 OCHF2 H 28 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 CF3 OCHF2 H (S)-isomer 29 CH(CH3)CH2SC2H5 3-Cl 2-CH3 CH2 1 Q1 CF3 OCHF2 H (S)-isomer 30 CH(CH3)CH2SOC2H5 3-Cl 2-CH3 CH2 1 Q1 CF3 OCHF2 H (S)-isomer 31 CH(CH3)CH2SO2C2H5 3-Cl 2-CH3 CH2 1 Q1 CF3 OCHF2 H (S)-isomer 32 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 H H C2F5 33 C(CH3)2CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 H H C2F5 34 C(CH3)2CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 H H C2F5 35 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 H H C2F5 36 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 H H C2F5 (S)-isomer 37 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 H H C2F5 38 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 H H C2F5 (S)-isomer 39 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 H H C2F5 40 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 H H C2F5 (S)-isomer 41 CH(CH3)CH2SC2H5 3-Cl 2-CH3 CH2 1 Q1 H H C2F5 (S)-isomer 42 CH(CH3)CH2SOC2H5 3-Cl 2-CH3 CH2 1 Q1 H H C2F5 (S)-isomer 43 CH(CH3)CH2SO2C2H5 3-Cl 2-CH3 CH2 1 Q1 H H C2F5 (S)-isomer 44 CH(CH3)2 3-Br 2-CH3 CH2 1 Q1 CF3 CF3 H 45 C(CH3)2CH2SCH3 3-Br 2-CH3 CH2 1 Q1 CF3 CF3 H 154-160 46 C(CH3)2CH2SOCH3 3-Br 2-CH3 CH2 1 Q1 CF3 CF3 H 47 C(CH3)2CH2SO2CH3 3-Br 2-CH3 CH2 1 Q1 CF3 CF3 H *** 48 CH(CH3)CH2SCH3 3-Br 2-CH3 CH2 1 Q1 CF3 CF3 H 147-155 49 CH(CH3)CH2SCH3 3-Br 2-CH3 CH2 1 Q1 CF3 CF3 H 80-86 (S)-isomer 50 CH(CH3)CH2SOCH3 3-Br 2-CH3 CH2 1 Q1 CF3 CF3 H 51 CH(CH3)CH2SOCH3 3-Br 2-CH3 CH2 1 Q1 CF3 CF3 H 207-209 (S)-isomer 52 CH(CH3)CH2SO2CH3 3-Br 2-CH3 CH2 1 Q1 CF3 CF3 H *** 53 CH(CH3)CH2SO2CH3 3-Br 2-CH3 CH2 1 Q1 CF3 CF3 H 77-85 (S)-isomer 54 CH(CH3)CH2SC2H5 3-Br 2-CH3 CH2 1 Q1 CF3 CF3 H (S)-isomer 55 CH(CH3)CH2SOC2H5 3-Br 2-CH3 CH2 1 Q1 CF3 CF3 H (S)-isomer 56 CH(CH3)CH2SO2C2H5 3-Br 2-CH3 CH2 1 Q1 CF3 CF3 H (S)-isomer 57 C(CH3)2CH2SCH3 3-Br 2-CH3 CH2 1 Q1 CF3 OCHF2 H 58 C(CH3)2SOCH3 3-Br 2-CH3 CH2 1 Q1 CF3 OCHF2 H 59 C(CH3)2CH2SO2CH3 3-Br 2-CH3 CH2 1 Q1 CF3 OCHF2 H 60 CH(CH3)CH2SCH3 3-Br 2-CH3 CH2 1 Q1 CF3 OCHF2 H 61 CH(CH3)CH2SCH3 3-Br 2-CH3 CH2 1 Q1 CF3 OCHF2 H (S)-isomer 62 CH(CH3)CH2SOCH3 3-Br 2-CH3 CH2 1 Q1 CF3 OCHF2 H 63 CH(CH3)CH2SOCH3 3-Br 2-CH3 CH2 1 Q1 CF3 OCHF2 H (S)-isomer 64 CH(CH3)CH2SO2CH3 3-Br 2-CH3 CH2 1 Q1 CF3 OCHF2 H 65 CH(CH3)CH2SO2CH3 3-Br 2-CH3 CH2 1 Q1 CF3 OCHF2 H (S)-isomer 66 CH(CH3)CH2SC2H5 3-Br 2-CH3 CH2 1 Q1 CF3 OCHF2 H (S)-isomer 67 CH(CH3)CH2SOC2H5 3-Br 2-CH3 CH2 1 Q1 CF3 OCHF2 H (S)-isomer 68 CH(CH3)CH2SO2C2H5 3-Br 2-CH3 CH2 1 Q1 CF3 OCHF2 H (S)-isomer 69 C(CH3)2CH2SCH3 3-Br 2-CH3 CH2 1 Q1 H H C2F5 70 C(CH3)2CH2SOCH3 3-Br 2-CH3 CH2 1 Q1 H H C2F5 71 C(CH3)2CH2SO2CH3 3-Br 2-CH3 CH2 1 Q1 H H C2F5 72 CH(CH3)CH2SCH3 3-Br 2-CH3 CH2 1 Q1 H H C2F5 73 CH(CH3)CH2SCH3 3-Br 2-CH3 CH2 1 Q1 H H C2F5 (S)-isomer 74 CH(CH3)CH2SOCH3 3-Br 2-CH3 CH2 1 Q1 H H C2F5 75 CH(CH3)CH2SOCH3 3-Br 2-CH3 CH2 1 Q1 H H C2F5 (S)-isomer 76 CH(CH3)CH2SO2CH3 3-Br 2-CH3 CH2 1 Q1 H H C2F5 77 CH(CH3)CH2SO2CH3 3-Br 2-CH3 CH2 1 Q1 H H C2F5 (S)-isomer 78 CH(CH3)CH2SC2H5 3-Br 2-CH3 CH2 1 Q1 H H C2F5 (S)-isomer 79 CH(CH3)CH2SOC2H5 3-Br 2-CH3 CH2 1 Q1 H H C2F5 (S)-isomer 80 CH(CH3)CH2SO2C2H5 3-Br 2-CH3 CH2 1 Q1 H H C2F5 (S)-isomer 81 CH(CH3)2 3-I 2-CH3 CH2 1 Q1 CF3 CF3 H *** 82 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF3 CF3 H 83-87 83 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q1 CF3 CF3 H *** 84 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 CF3 CF3 H 104-107 85 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF3 CF3 H *** 86 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF3 CF3 H 85-93 (S)-isomer 87 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 CF3 CF3 H 213-215 88 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 CF3 CF3 H 193-195 (S)-isomer 89 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 CF3 CF3 H *** 90 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 CF3 CF3 H 87-93 (S)-isomer 91 CH(CH3)CH2SC2H5 3-I 2-CH3 CH2 1 Q1 CF3 CF3 H 79-83 (S)-isomer 92 CH(CH3)CH2SOC2H5 3-I 2-CH3 CH2 1 Q1 CF3 CF3 H (S)-isomer 93 CH(CH3)CH2SO2C2H5 3-I 2-CH3 CH2 1 Q1 CF3 CF3 H 79-91 (S)-isomer 94 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 H C3F7-n H *** 95 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q1 H C3F7-n H 96 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 H C3F7-n H *** 97 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 H C3F7-n H *** 98 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 H C3F7-n H 99 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 H C3F7-n H *** 100 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF3 OCHF2 H 101 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q1 CF3 OCHF2 H 102 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 CF3 OCHF2 H 103 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF3 OCHF2 H *** 104 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF3 OCHF2 H (S)-isomer 105 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 CF3 OCHF2 H 106 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 CF3 OCHF2 H (S)-isomer 107 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 CF3 OCHF2 H *** 108 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 CF3 OCHF2 H (S)-isomer 109 CH(CH3)CH2SC2H5 3-I 2-CH3 CH2 1 Q1 CF3 OCHF2 H (S)-isomer 110 CH(CH3)CH2SOC2H5 3-I 2-CH3 CH2 1 Q1 CF3 OCHF2 H (S)-isomer 111 CH(CH3)CH2SO2C2H5 3-I 2-CH3 CH2 1 Q1 CF3 OCHF2 H (S)-isomer 112 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 H H C2F5 113 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q1 H H C2F5 114 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 H H C2F5 115 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 H H C2F5 116 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 H H C2F5 *** (S)-isomer 117 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 H H C2F5 118 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 H H C2F5 (S)-isomer 119 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 H H C2F5 120 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 H H C2F5 (S)-isomer 121 CH(CH3)CH2SC2H5 3-I 2-CH3 CH2 1 Q1 H H C2F5 (S)-isomer 122 CH(CH3)CH2SOC2H5 3-I 2-CH3 CH2 1 Q1 H H C2F5 (S)-isomer 123 CH(CH3)CH2SO2C2H5 3-I 2-CH3 CH2 1 Q1 H H C2F5 (S)-isomer 124 C(CH3)2CH2SCH3 3-OSO2CH3 2-CH3 CH2 1 Q1 CF3 CF3 H 125 C(CH3)2CH2SOCH3 3-OSO2CH3 2-CH3 CH2 1 Q1 CF3 CF3 H 126 C(CH3)2CH2SO2CH3 3-OSO2CH3 2-CH3 CH2 1 Q1 CF3 CF3 H 127 CH(CH3)CH2SCH3 3-OSO2CH3 2-CH3 CH2 1 Q1 CF3 CF3 H 128 CH(CH3)CH2SCH3 3-OSO2CH3 2-CH3 CH2 1 Q1 CF3 CF3 H 177-180 (S)-isomer 129 CH(CH3)CH2SOCH3 3-OSO2CH3 2-CH3 CH2 1 Q1 CF3 CF3 H 130 CH(CH3)CH2SOCH3 3-OSO2CH3 2-CH3 CH2 1 Q1 CF3 CF3 H (S)-isomer 131 CH(CH3)CH2SO2CH3 3-OSO2CH3 2-CH3 CH2 1 Q1 CF3 CF3 H 132 CH(CH3)CH2SO2CH3 3-OSO2CH3 2-CH3 CH2 1 Q1 CF3 CF3 H 85-93 (S)-isomer 133 CH(CH3)CH2SC2H5 3-OSO2CH3 2-CH3 CH2 1 Q1 CF3 CF3 H (S)-isomer 134 CH(CH3)CH2SOC2H5 3-OSO2CH3 2-CH3 CH2 1 Q1 CF3 CF3 H (S)-isomer 135 CH(CH3)CH2SO2C2H5 3-OSO2CH3 2-CH3 CH2 1 Q1 CF3 CF3 H (S)-isomer 136 CH(CH3)2 3-Cl 2-CH3 CH2 1 Q2 CF3 CF3 — 137 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q2 CF3 CF3 — 70-72 138 C(CH3)2CH2SOCH3 3-Cl 2-CH3 CH2 1 Q2 CF3 CF3 — 84-90 139 C(CH3)2CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q2 CF3 CF3 — 88-95 140 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q2 CF3 CF3 — 76-80 141 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q2 CF3 CF3 — 72-81 (S)-isomer 142 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q2 CF3 CF3 — 186-188 143 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q2 CF3 CF3 — 195-198 (S)-isomer 144 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q2 CF3 CF3 — 116-118 145 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q2 CF3 CF3 — 95-99 (S)-isomer 146 CH(CH3)CH2SC2H5 3-Cl 2-CH3 CH2 1 Q2 CF3 CF3 — 73-76 (S)-isomer 147 CH(CH3)CH2SOC2H5 3-Cl 2-CH3 CH2 1 Q2 CF3 CF3 — 180-183 (S)-isomer 148 CH(CH3)CH2SO2C2H5 3-Cl 2-CH3 CH2 1 Q2 CF3 CF3 — 66-72 (S)-isomer 149 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q2 C2F5 CF3 — *** 150 C(CH3)2CH2SOCH3 3-Cl 2-CH3 CH2 1 Q2 C2F5 CF3 — 59-64 151 C(CH3)2CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q2 C2F5 CF3 — 82-87 152 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q2 C2F5 CF3 — 153 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q2 C2F5 CF3 — *** (S)-isomer 154 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q2 C2F5 CF3 — 155 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q2 C2F5 CF3 — 175-178 (S)-isomer 156 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q2 C2F5 CF3 — 157 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q2 C2F5 CF3 — 82-90 (S)-isomer 158 CH(CH3)CH2SC2H5 3-Cl 2-CH3 CH2 1 Q2 C2F5 CF3 — (S)-isomer 159 CH(CH3)CH2SOC2H5 3-Cl 2-CH3 CH2 1 Q2 C2F5 CF3 — (S)-isomer 160 CH(CH3)CH2SO2C2H5 3-Cl 2-CH3 CH2 1 Q2 C2F5 CF3 — (S)-isomer 161 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q2 CF3 CHF2 — 162 C(CH3)2CH2SOCH3 3-Cl 2-CH3 CH2 1 Q2 CF3 CHF2 — 163 C(CH3)2CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q2 CF3 CHF2 — 164 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q2 CF3 CHF2 — 165 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q2 CF3 CHF2 — (S)-isomer 166 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q2 CF3 CHF2 — 167 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q2 CF3 CHF2 — (S)-isomer 168 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q2 CF3 CHF2 — 169 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q2 CF3 CHF2 — (S)-isomer 170 CH(CH3)CH2SC2H5 3-Cl 2-CH3 CH2 1 Q2 CF3 CHF2 — (S)-isomer 171 CH(CH3)CH2SOC2H5 3-Cl 2-CH3 CH2 1 Q2 CF3 CHF2 — (S)-isomer 172 CH(CH3)CH2SO2C2H5 3-Cl 2-CH3 CH2 1 Q2 CF3 CHF2 — (S)-isomer 173 CH(CH3)2 3-Br 2-CH3 CH2 1 Q2 CF3 CF3 — 174 C(CH3)2CH2SCH3 3-Br 2-CH3 CH2 1 Q2 CF3 CF3 — 77-82 175 C(CH3)2CH2SOCH3 3-Br 2-CH3 CH2 1 Q2 CF3 CF3 — 176 C(CH3)2CH2SO2CH3 3-Br 2-CH3 CH2 1 Q2 CF3 CF3 — 151-155 177 CH(CH3)CH2SCH3 3-Br 2-CH3 CH2 1 Q2 CF3 CF3 — 167-169 178 CH(CH3)CH2SCH3 3-Br 2-CH3 CH2 1 Q2 CF3 CF3 — 68-73 (S)-isomer 179 CH(CH3)CH2SOCH3 3-Br 2-CH3 CH2 1 Q2 CF3 CF3 — 180 CH(CH3)CH2SOCH3 3-Br 2-CH3 CH2 1 Q2 CF3 CF3 — *** (S)-isomer 181 CH(CH3)CH2SO2CH3 3-Br 2-CH3 CH2 1 Q2 CF3 CF3 — 90-98 182 CH(CH3)CH2SO2CH3 3-Br 2-CH3 CH2 1 Q2 CF3 CF3 — 99-112 (S)-isomer 183 CH(CH3)CH2SC2H5 3-Br 2-CH3 CH2 1 Q2 CF3 CF3 — (S)-isomer 184 CH(CH3)CH2SOC2H5 3-Br 2-CH3 CH2 1 Q2 CF3 CF3 — (S)-isomer 185 CH(CH3)CH2SO2C2H5 3-Br 2-CH3 CH2 1 Q2 CF3 CF3 — (S)-isomer 186 C(CH3)2CH2SCH3 3-Br 2-CH3 CH2 1 Q2 C2F5 CF3 — 187 C(CH3)2CH2SOCH3 3-Br 2-CH3 CH2 1 Q2 C2F5 CF3 — 188 C(CH3)2CH2SO2CH3 3-Br 2-CH3 CH2 1 Q2 C2F5 CF3 — 189 CH(CH3)CH2SCH3 3-Br 2-CH3 CH2 1 Q2 C2F5 CF3 — 190 CH(CH3)CH2SCH3 3-Br 2-CH3 CH2 1 Q2 C2F5 CF3 — (S)-isomer 191 CH(CH3)CH2SOCH3 3-Br 2-CH3 CH2 1 Q2 C2F5 CF3 — 192 CH(CH3)CH2SOCH3 3-Br 2-CH3 CH2 1 Q2 C2F5 CF3 — (S)-isomer 193 CH(CH3)CH2SO2CH3 3-Br 2-CH3 CH2 1 Q2 C2F5 CF3 — 194 CH(CH3)CH2SO2CH3 3-Br 2-CH3 CH2 1 Q2 C2F5 CF3 — (S)-isomer 195 CH(CH3)CH2SC2H5 3-Br 2-CH3 CH2 1 Q2 C2F5 CF3 — (S)-isomer 196 CH(CH3)CH2SOC2H5 3-Br 2-CH3 CH2 1 Q2 C2F5 CF3 — (S)-isomer 197 CH(CH3)CH2SO2C2H5 3-Br 2-CH3 CH2 1 Q2 C2F5 CF3 — (S)-isomer 198 C(CH3)2CH2SCH3 3-Br 2-CH3 CH2 1 Q2 CF3 CHF2 — 199 C(CH3)2CH2SOCH3 3-Br 2-CH3 CH2 1 Q2 CF3 CHF2 — 200 C(CH3)2CH2SO2CH3 3-Br 2-CH3 CH2 1 Q2 CF3 CHF2 — 201 CH(CH3)CH2SCH3 3-Br 2-CH3 CH2 1 Q2 CF3 CHF2 — 202 CH(CH3)CH2SCH3 3-Br 2-CH3 CH2 1 Q2 CF3 CHF2 — (S)-isomer 203 CH(CH3)CH2SOCH3 3-Br 2-CH3 CH2 1 Q2 CF3 CHF2 — 204 CH(CH3)CH2SOCH3 3-Br 2-CH3 CH2 1 Q2 CF3 CHF2 — (S)-isomer 205 CH(CH3)CH2SO2CH3 3-Br 2-CH3 CH2 1 Q2 CF3 CHF2 — 206 CH(CH3)CH2SO2CH3 3-Br 2-CH3 CH2 1 Q2 CF3 CHF2 — (S)-isomer 207 CH(CH3)CH2SC2H5 3-Br 2-CH3 CH2 1 Q2 CF3 CHF2 — (S)-isomer 208 CH(CH3)CH2SOC2H5 3-Br 2-CH3 CH2 1 Q2 CF3 CHF2 — (S)-isomer 209 CH(CH3)CH2SO2C2H5 3-Br 2-CH3 CH2 1 Q2 CF3 CHF2 — (S)-isomer 210 CH(CH3)2 3-I 2-CH3 CH2 1 Q2 CF3 CF3 — 102-105 211 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q2 CF3 CF3 — 93-97 212 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q2 CF3 CF3 — 92-93 213 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q2 CF3 CF3 — 104-107 214 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q2 CF3 CF3 — 92-95 215 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q2 CF3 CF3 — 81-90 (S)-isomer 216 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q2 CF3 CF3 — 192-195 217 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q2 CF3 CF3 — 192-199 (S)-isomer 218 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q2 CF3 CF3 — 99-104 219 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q2 CF3 CF3 — 164-167 (S)-isomer 220 CH(CH3)CH2SC2H5 3-I 2-CH3 CH2 1 Q2 CF3 CF3 — 90-94 (S)-isomer 221 CH(CH3)CH2SOC2H5 3-I 2-CH3 CH2 1 Q2 CF3 CF3 — 201-205 (S)-isomer 222 CH(CH3)CH2SO2C2H5 3-I 2-CH3 CH2 1 Q2 CF3 CF3 — 91-99 (S)-isomer 223 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q2 C2F5 CF3 — 224 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q2 C2F5 CF3 — 225 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q2 C2F5 CF3 — 226 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q2 C2F5 CF3 — 89-94 227 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q2 C2F5 CF3 — 91-104 (S)-isomer 228 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q2 C2F5 CF3 — 229 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q2 C2F5 CF3 — 190-193 (S)-isomer 230 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q2 C2F5 CF3 — 99-116 231 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q2 C2F5 CF3 — 126-132 (S)-isomer 232 CH(CH3)CH2SC2H5 3-I 2-CH3 CH2 1 Q2 C2F5 CF3 — (S)-isomer 233 CH(CH3)CH2SOC2H5 3-I 2-CH3 CH2 1 Q2 C2F5 CF3 — (S)-isomer 234 CH(CH3)CH2SO2C2H5 3-I 2-CH3 CH2 1 Q2 C2F5 CF3 — (S)-isomer 235 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q2 CF3 CHF2 — 236 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q2 CF3 CHF2 — 237 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q2 CF3 CHF2 238 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q2 CF3 CHF2 — 85-88 239 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q2 CF3 CHF2 — 160-161 (S)-isomer 240 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q2 CF3 CHF2 — 241 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q2 CF3 CHF2 — (S)-isomer 242 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q2 CF3 CHF2 — *** 243 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q2 CF3 CHF2 — 174-178 (S)-isomer 244 CH(CH3)CH2SC2H5 3-I 2-CH3 CH2 1 Q2 CF3 CHF2 — (S)-isomer 245 CH(CH3)CH2SOC2H5 3-I 2-CH3 CH2 1 Q2 CF3 CHF2 — (S)-isomer 246 CH(CH3)CH2SO2C2H5 3-I 2-CH3 CH2 1 Q2 CF3 CHF2 — (S)-isomer 247 C(CH3)2CH2SCH3 3-OSO2CH3 2-CH3 CH2 1 Q2 CF3 CF3 — 248 C(CH3)2CH2SOCH3 3-OSO2CH3 2-CH3 CH2 1 Q2 CF3 CF3 — 249 C(CH3)2CH2SO2CH3 3-OSO2CH3 2-CH3 CH2 1 Q2 CF3 CF3 — 250 CH(CH3)CH2SCH3 3-OSO2CH3 2-CH3 CH2 1 Q2 CF3 CF3 — 251 CH(CH3)CH2SCH3 3-OSO2CH3 2-CH3 CH2 1 Q2 CF3 CF3 — *** (S)-isomer 252 CH(CH3)CH2SOCH3 3-OSO2CH3 2-CH3 CH2 1 Q2 CF3 CF3 — 253 CH(CH3)CH2SOCH3 3-OSO2CH3 2-CH3 CH2 1 Q2 CF3 CF3 — (S)-isomer 254 CH(CH3)CH2SO2CH3 3-OSO2CH3 2-CH3 CH2 1 Q2 CF3 CF3 — 255 CH(CH3)CH2SO2CH3 3-OSO2CH3 2-CH3 CH2 1 Q2 CF3 CF3 — 207-208 (S)-isomer 256 CH(CH3)CH2SC2H5 3-OSO2CH3 2-CH3 CH2 1 Q2 CF3 CF3 — (S)-isomer 257 CH(CH3)CH2SOC2H5 3-OSO2CH3 2-CH3 CH2 1 Q2 CF3 CF3 — (S)-isomer 258 CH(CH3)CH2SO2C2H5 3-OSO2CH3 2-CH3 CH2 1 Q2 CF3 CF3 — (S)-isomer 259 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q3 OCHF2 CHF2 CF3 260 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q3 OCHF2 CHF2 CF3 261 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q3 OCHF2 CHF2 CF3 262 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q3 OCHF2 CHF2 CF3 82-90 263 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q3 OCHF2 CHF2 CF3 264 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q3 OCHF2 CHF2 CF3 88-99 265 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q4 OCHF2 CHF2 CF3 266 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q4 OCHF2 CHF2 CF3 267 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q4 OCHF2 CHF2 CF3 268 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q4 OCHF2 CHF2 CF3 149-151 269 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q4 OCHF2 CHF2 CF3 270 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q4 OCHF2 CHF2 CF3 81-90 271 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q5 CF3 CF3 OH *** 272 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q5 CF3 CF3 OH 273 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q5 CF3 CF3 OH 274 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q5 CF3 CF3 OH 275 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q5 CF3 CF3 OH 276 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q5 CF3 CF3 OH 277 CH(CH3)2 3-I 2-CH3 CH2 1 Q6 Cl Cl H *** 278 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q6 H CF3 CF3 279 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q6 H CF3 CF3 280 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q6 H CF3 CF3 281 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q6 H CF3 CF3 149-158 (S)-isomer 282 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q6 H CF3 CF3 283 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q6 H CF3 CF3 284 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q7 CH2CF3 CF3 — 285 C(CH3)2SOCH3 3-I 2-CH3 CH2 1 Q7 CH2CF3 CF3 — 286 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q7 CH2CF3 CF3 — 287 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q7 CH2CF3 CF3 — 288 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q7 CH2CF3 CF3 — 289 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q7 CH2CF3 CF3 — 290 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q8 CH2CF3 CF3 — 291 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q8 CH2CF3 CF3 — 292 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q8 CH2CF3 CF3 — 293 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q8 CH2CF3 CF3 — 294 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q8 CH2CF3 CF3 — 295 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q8 CH2CF3 CF3 — 296 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q9 CF3 CF3 — 297 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q9 CF3 CF3 — 298 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q9 CF3 CF3 — 299 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q9 CF3 CF3 — 65-79 (S)-isomer 300 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q9 CF3 CF3 — 301 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q9 CF3 CF3 — 302 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q10 CF3 CF3 H 303 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q10 CF3 CF3 H 304 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q10 CF3 CF3 H 305 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q10 CF3 CF3 H 306 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q10 CF3 CF3 H 307 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q10 CF3 CF3 H 308 C(CH3)2CH2SCH3 3-I 2-CH3 O 1 Q10 CF3 CF3 H 179-181 309 C(CH3)2CH2SOCH3 3-I 2-CH3 O 1 Q10 CF3 CF3 H 310 C(CH3)2CH2SO2CH3 3-I 2-CH3 O 1 Q10 CF3 CF3 H 148-153 311 CH(CH3)CH2SCH3 3-I 2-CH3 O 1 Q10 CF3 CF3 H 312 CH(CH3)CH2SOCH3 3-I 2-CH3 O 1 Q10 CF3 CF3 H 313 CH(CH3)CH2SO2CH3 3-I 2-CH3 O 1 Q10 CF3 CF3 H 314 C(CH3)2CH2SCH3 3-Cl 2-CH3 — 0 Q1 CF3 CF3 H 315 C(CH3)2CH2SOCH3 3-Cl 2-CH3 — 0 Q1 CF3 CF3 H 316 C(CH3)2CH2SO2CH3 3-Cl 2-CH3 — 0 Q1 CF3 CF3 H 317 CH(CH3)CH2SCH3 3-Cl 2-CH3 — 0 Q1 CF3 CF3 H 318 CH(CH3)CH2SCH3 3-Cl 2-CH3 — 0 Q1 CF3 CF3 H 209-210 (S)-isomer 319 CH(CH3)CH2SOCH3 3-Cl 2-CH3 — 0 Q1 CF3 CF3 H 320 CH(CH3)CH2SOCH3 3-Cl 2-CH3 — 0 Q1 CF3 CF3 H (S)-isomer 321 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 — 0 Q1 CF3 CF3 H 322 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 — 0 Q1 CF3 CF3 H 218-219 (S)-isomer 323 CH(CH3)CH2SC2H5 3-Cl 2-CH3 — 0 Q1 CF3 CF3 H (S)-isomer 324 CH(CH3)CH2SOC2H5 3-Cl 2-CH3 — 0 Q1 CF3 CF3 H (S)-isomer 325 CH(CH3)CH2SO2C2H5 3-Cl 2-CH3 — 0 Q1 CF3 CF3 H (S)-isomer 326 C(CH3)2CH2SCH3 3-Cl 2-CH3 — 0 Q1 H C2F5 H 327 C(CH3)2CH2SOCH3 3-Cl 2-CH3 — 0 Q1 H C2F5 H 328 C(CH3)2CH2SO2CH3 3-Cl 2-CH3 — 0 Q1 H C2F5 H 329 CH(CH3)CH2SCH3 3-Cl 2-CH3 — 0 Q1 H C2F5 H 330 CH(CH3)CH2SCH3 3-Cl 2-CH3 — 0 Q1 H C2F5 H (S)-isomer 331 CH(CH3)CH2SOCH3 3-Cl 2-CH3 — 0 Q1 H C2F5 H 332 CH(CH3)CH2SOCH3 3-Cl 2-CH3 — 0 Q1 H C2F5 H (S)-isomer 333 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 — 0 Q1 H C2F5 H 334 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 — 0 Q1 H C2F5 H (S)-isomer 335 CH(CH3)CH2SC2H5 3-Cl 2-CH3 — 0 Q1 H C2F5 H (S)-isomer 336 CH(CH3)CH2SOC2H5 3-Cl 2-CH3 — 0 Q1 H C2F5 H (S)-isomer 337 CH(CH3)CH2SO2C2H5 3-Cl 2-CH3 — 0 Q1 H C2F5 H (S)-isomer 338 C(CH3)2CH2SCH3 3-Cl 2-CH3 — 0 Q1 C2F5 H H 339 C(CH3)2CH2SOCH3 3-Cl 2-CH3 — 0 Q1 C2F5 H H 340 C(CH3)2CH2SO2CH3 3-Cl 2-CH3 — 0 Q1 C2F5 H H 341 CH(CH3)CH2SCH3 3-Cl 2-CH3 — 0 Q1 C2F5 H H 342 CH(CH3)CH2SCH3 3-Cl 2-CH3 — 0 Q1 C2F5 H H (S)-isomer 343 CH(CH3)CH2SOCH3 3-Cl 2-CH3 — 0 Q1 C2F5 H H 344 CH(CH3)CH2SOCH3 3-Cl 2-CH3 — 0 Q1 C2F5 H H (S)-isomer 345 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 — 0 Q1 C2F5 H H 346 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 — 0 Q1 C2F5 H H (S)-isomer 347 CH(CH3)CH2SC2H5 3-Cl 2-CH3 — 0 Q1 C2F5 H H (S)-isomer 348 CH(CH3)CH2SOC2H5 3-Cl 2-CH3 — 0 Q1 C2F5 H H (S)-isomer 349 CH(CH3)CH2SO2C2H5 3-Cl 2-CH3 — 0 Q1 C2F5 H H (S)-isomer 350 C(CH3)2CH2SCH3 3-Cl 2-CH3 — 0 Q1 H H C2F5 351 C(CH3)2CH2SOCH3 3-Cl 2-CH3 — 0 Q1 H H C2F5 352 C(CH3)2CH2SO2CH3 3-Cl 2-CH3 — 0 Q1 H H C2F5 353 CH(CH3)CH2SCH3 3-Cl 2-CH3 — 0 Q1 H H C2F5 354 CH(CH3)CH2SCH3 3-Cl 2-CH3 — 0 Q1 H H C2F5 (S)-isomer 355 CH(CH3)CH2SOCH3 3-Cl 2-CH3 — 0 Q1 H H C2F5 356 CH(CH3)CH2SOCH3 3-Cl 2-CH3 — 0 Q1 H H C2F5 (S)-isomer 357 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 — 0 Q1 H H C2F5 358 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 — 0 Q1 H H C2F5 (S)-isomer 359 CH(CH3)CH2SC2H5 3-Cl 2-CH3 — 0 Q1 H H C2F5 (S)-isomer 360 CH(CH3)CH2SOC2H5 3-Cl 2-CH3 — 0 Q1 H H C2F5 (S)-isomer 361 CH(CH3)CH2SO2C2H5 3-Cl 2-CH3 — 0 Q1 H H C2F5 (S)-isomer 362 C(CH3)2CH2SCH3 3-Br 2-CH3 — 0 Q1 CF3 CF3 H 363 C(CH3)2CH2SOCH3 3-Br 2-CH3 — 0 Q1 CF3 CF3 H 364 C(CH3)2CH2SO2CH3 3-Br 2-CH3 — 0 Q1 CF3 CF3 H 365 CH(CH3)CH2SCH3 3-Br 2-CH3 — 0 Q1 CF3 CF3 H 366 CH(CH3)CH2SCH3 3-Br 2-CH3 — 0 Q1 CF3 CF3 H (S)-isomer 367 CH(CH3)CH2SOCH3 3-Br 2-CH3 — 0 Q1 CF3 CF3 H 368 CH(CH3)CH2SOCH3 3-Br 2-CH3 — 0 Q1 CF3 CF3 H (S)-isomer 369 CH(CH3)CH2SO2CH3 3-Br 2-CH3 — 0 Q1 CF3 CF3 H 370 CH(CH3)CH2SO2CH3 3-Br 2-CH3 — 0 Q1 CF3 CF3 H (S)-isomer 371 CH(CH3)CH2SC2H5 3-Br 2-CH3 — 0 Q1 CF3 CF3 H (S)-isomer 372 CH(CH3)CH2SOC2H5 3-Br 2-CH3 — 0 Q1 CF3 CF3 H (S)-isomer 373 CH(CH3)CH2SO2C2H5 3-Br 2-CH3 — 0 Q1 CF3 CF3 H (S)-isomer 374 C(CH3)2CH2SCH3 3-Br 2-CH3 — 0 Q1 H C2F5 H 375 C(CH3)2CH2SOCH3 3-Br 2-CH3 — 0 Q1 H C2F5 H 376 C(CH3)2CH2SO2CH3 3-Br 2-CH3 — 0 Q1 H C2F5 H 377 CH(CH3)CH2SCH3 3-Br 2-CH3 — 0 Q1 H C2F5 H 378 CH(CH3)CH2SCH3 3-Br 2-CH3 — 0 Q1 H C2F5 H (S)-isomer 379 CH(CH3)CH2SOCH3 3-Br 2-CH3 — 0 Q1 H C2F5 H 380 CH(CH3)CH2SOCH3 3-Br 2-CH3 — 0 Q1 H C2F5 H (S)-isomer 381 CH(CH3)CH2SO2CH3 3-Br 2-CH3 — 0 Q1 H C2F5 H 382 CH(CH3)CH2SO2CH3 3-Br 2-CH3 — 0 Q1 H C2F5 H (S)-isomer 383 CH(CH3)CH2SC2H5 3-Br 2-CH3 — 0 Q1 H C2F5 H (S)-isomer 384 CH(CH3)CH2SOC2H5 3-Br 2-CH3 — 0 Q1 H C2F5 H (S)-isomer 385 CH(CH3)CH2SO2C2H5 3-Br 2-CH3 — 0 Q1 H C2F5 H (S)-isomer 386 C(CH3)2CH2SCH3 3-Br 2-CH3 — 0 Q1 C2F5 H H 387 C(CH3)2CH2SOCH3 3-Br 2-CH3 — 0 Q1 C2F5 H H 388 C(CH3)2CH2SO2CH3 3-Br 2-CH3 — 0 Q1 C2F5 H H 389 CH(CH3)CH2SCH3 3-Br 2-CH3 — 0 Q1 C2F5 H H 390 CH(CH3)CH2SCH3 3-Br 2-CH3 — 0 Q1 C2F5 H H (S)-isomer 391 CH(CH3)CH2SOCH3 3-Br 2-CH3 — 0 Q1 C2F5 H H 392 CH(CH3)CH2SOCH3 3-Br 2-CH3 — 0 Q1 C2F5 H H (S)-isomer 393 CH(CH3)CH2SO2CH3 3-Br 2-CH3 — 0 Q1 C2F5 H H 394 CH(CH3)CH2SO2CH3 3-Br 2-CH3 — 0 Q1 C2F5 H H (S)-isomer 395 CH(CH3)CH2SC2H5 3-Br 2-CH3 — 0 Q1 C2F5 H H (S)-isomer 396 CH(CH3)CH2SOC2H5 3-Br 2-CH3 — 0 Q1 C2F5 H H (S)-isomer 397 CH(CH3)CH2SO2C2H5 3-Br 2-CH3 — 0 Q1 C2F5 H H (S)-isomer 398 C(CH3)2CH2SCH3 3-Br 2-CH3 — 0 Q1 H H C2F5 399 C(CH3)2CH2SOCH3 3-Br 2-CH3 — 0 Q1 H H C2F5 400 C(CH3)2CH2SO2CH3 3-Br 2-CH3 — 0 Q1 H H C2F5 401 CH(CH3)CH2SCH3 3-Br 2-CH3 — 0 Q1 H H C2F5 402 CH(CH3)CH2SCH3 3-Br 2-CH3 — 0 Q1 H H C2F5 (S)-isomer 403 CH(CH3)CH2SOCH3 3-Br 2-CH3 — 0 Q1 H H C2F5 404 CH(CH3)CH2SOCH3 3-Br 2-CH3 — 0 Q1 H H C2F5 (S)-isomer 405 CH(CH3)CH2SO2CH3 3-Br 2-CH3 — 0 Q1 H H C2F5 406 CH(CH3)CH2SO2CH3 3-Br 2-CH3 — 0 Q1 H H C2F5 (S)-isomer 407 CH(CH3)CH2SC2H5 3-Br 2-CH3 — 0 Q1 H H C2F5 (S)-isomer 408 CH(CH3)CH2SOC2H5 3-Br 2-CH3 — 0 Q1 H H C2F5 (S)-isomer 409 CH(CH3)CH2SO2C2H5 3-Br 2-CH3 — 0 Q1 H H C2F5 (S)-isomer 410 C(CH3)2CH2SCH3 3-I 2-CH3 — 0 Q1 CF3 CF3 H 411 C(CH3)2CH2SOCH3 3-I 2-CH3 — 0 Q1 CF3 CF3 H 412 C(CH3)2CH2SO2CH3 3-I 2-CH3 — 0 Q1 CF3 CF3 H 413 CH(CH3)CH2SCH3 3-I 2-CH3 — 0 Q1 CF3 CF3 H 201 414 CH(CH3)CH2SCH3 3-I 2-CH3 — 0 Q1 CF3 CF3 H 192-206 (S)-isomer 415 CH(CH3)CH2SOCH3 3-I 2-CH3 — 0 Q1 CF3 CF3 H 416 CH(CH3)CH2SOCH3 3-I 2-CH3 — 0 Q1 CF3 CF3 H (S)-isomer 417 CH(CH3)CH2SO2CH3 3-I 2-CH3 — 0 Q1 CF3 CF3 H *** 418 CH(CH3)CH2SO2CH3 3-I 2-CH3 — 0 Q1 CF3 CF3 H (S)-isomer 419 CH(CH3)CH2SC2H5 3-I 2-CH3 — 0 Q1 CF3 CF3 H (S)-isomer 420 CH(CH3)CH2SOC2H5 3-I 2-CH3 — 0 Q1 CF3 CF3 H (S)-isomer 421 CH(CH3)CH2SO2C2H5 3-I 2-CH3 — 0 Q1 CF3 CF3 H (S)-isomer 422 C(CH3)2CH2SCH3 3-I 2-CH3 — 0 Q1 H C2F5 H *** 423 C(CH3)2CH2SOCH3 3-I 2-CH3 — 0 Q1 H C2F5 H 424 C(CH3)2CH2SO2CH3 3-I 2-CH3 — 0 Q1 H C2F5 H 425 CH(CH3)CH2SCH3 3-I 2-CH3 — 0 Q1 H C2F5 H 426 CH(CH3)CH2SCH3 3-I 2-CH3 — 0 Q1 H C2F5 H (S)-isomer 427 CH(CH3)CH2SOCH3 3-I 2-CH3 — 0 Q1 H C2F5 H 428 CH(CH3)CH2SOCH3 3-I 2-CH3 — 0 Q1 H C2F5 H (S)-isomer 428 CH(CH3)CH2SO2CH3 3-I 2-CH3 — 0 Q1 H C2F5 H 430 CH(CH3)CH2SO2CH3 3-I 2-CH3 — 0 Q1 H C2F5 H (S)-isomer 431 CH(CH3)CH2SC2H5 3-I 2-CH3 — 0 Q1 H C2F5 H (S)-isomer 432 CH(CH3)CH2SOC2H5 3-I 2-CH3 — 0 Q1 H C2F5 H (S)-isomer 433 CH(CH3)CH2SO2C2H5 3-I 2-CH3 — 0 Q1 H C2F5 H (S)-isomer 434 C(CH3)2CH2SCH3 3-I 2-CH3 — 0 Q1 C2F5 H H *** 435 C(CH3)2CH2SOCH3 3-I 2-CH3 — 0 Q1 C2F5 H H 436 C(CH3)2CH2SO2CH3 3-I 2-CH3 — 0 Q1 C2F5 H H 437 CH(CH3)CH2SCH3 3-I 2-CH3 — 0 Q1 C2F5 H H 438 CH(CH3)CH2SCH3 3-I 2-CH3 — 0 Q1 C2F5 H H (S)-isomer 439 CH(CH3)CH2SOCH3 3-I 2-CH3 — 0 Q1 C2F5 H H 440 CH(CH3)CH2SOCH3 3-I 2-CH3 — 0 Q1 C2F5 H H (S)-isomer 441 CH(CH3)CH2SO2CH3 3-I 2-CH3 — 0 Q1 C2F5 H H 442 CH(CH3)CH2SO2CH3 3-I 2-CH3 — 0 Q1 C2F5 H H (S)-isomer 443 CH(CH3)CH2SC2H5 3-I 2-CH3 — 0 Q1 C2F5 H H (S)-isomer 444 CH(CH3)CH2SOC2H5 3-I 2-CH3 — 0 Q1 C2F5 H H (S)-isomer 445 CH(CH3)CH2SO2C2H5 3-I 2-CH3 — 0 Q1 C2F5 H H (S)-isomer 446 C(CH3)2CH2SCH3 3-I 2-CH3 — 0 Q1 H H C2F5 155-157 447 C(CH3)2CH2SOCH3 3-I 2-CH3 — 0 Q1 H H C2F5 448 C(CH3)2CH2SO2CH3 3-I 2-CH3 — 0 Q1 H H C2F5 162-168 449 CH(CH3)CH2SCH3 3-I 2-CH3 — 0 Q1 H H C2F5 450 CH(CH3)CH2SCH3 3-I 2-CH3 — 0 Q1 H H C2F5 (S)-isomer 451 CH(CH3)CH2SOCH3 3-I 2-CH3 — 0 Q1 H H C2F5 452 CH(CH3)CH2SOCH3 3-I 2-CH3 — 0 Q1 H H C2F5 (S)-isomer 453 CH(CH3)CH2SO2CH3 3-I 2-CH3 — 0 Q1 H H C2F5 454 CH(CH3)CH2SO2CH3 3-I 2-CH3 — 0 Q1 H H C2F5 (S)-isomer 455 CH(CH3)CH2SC2H5 3-I 2-CH3 — 0 Q1 H H C2F5 (S)-isomer 456 CH(CH3)CH2SOC2H5 3-I 2-CH3 — 0 Q1 H H C2F5 (S)-isomer 457 CH(CH3)CH2SO2C2H5 3-I 2-CH3 — 0 Q1 H H C2F5 (S)-isomer 458 C(CH3)2CH2SCH3 3-I 2-CH3 — 0 Q1 CH3 CF3 H 459 C(CH3)2CH2SOCH3 3-I 2-CH3 — 0 Q1 CH3 CF3 H 460 C(CH3)2CH2SO2CH3 3-I 2-CH3 — 0 Q1 CH3 CF3 H 461 CH(CH3)CH2SCH3 3-I 2-CH3 — 0 Q1 CH3 CF3 H 178-180 462 CH(CH3)CH2SOCH3 3-I 2-CH3 — 0 Q1 CH3 CF3 H 463 CH(CH3)CH2SO2CH3 3-I 2-CH3 — 0 Q1 CH3 CF3 H 101-112 464 C(CH3)2CH2SCH3 3-I 2-CH3 — 0 Q1 CF3 CH3 H 465 C(CH3)2CH2SOCH3 3-I 2-CH3 — 0 Q1 CF3 CH3 H 466 C(CH3)2CH2SO2CH3 3-I 2-CH3 — 0 Q1 CF3 CH3 H 467 CH(CH3)CH2SCH3 3-I 2-CH3 — 0 Q1 CF3 CH3 H 187-192 468 CH(CH3)CH2SOCH3 3-I 2-CH3 — 0 Q1 CF3 CH3 H 469 CH(CH3)CH2SO2CH3 3-I 2-CH3 — 0 Q1 CF3 CH3 H 108-116 470 C(CH3)2CH2SCH3 3-I 2-CH3 — 0 Q1 C2F5 CF3 H 471 C(CH3)2CH2SOCH3 3-I 2-CH3 — 0 Q1 C2F5 CF3 H 472 C(CH3)2CH2SO2CH3 3-I 2-CH3 — 0 Q1 C2F5 CF3 H 473 CH(CH3)CH2SCH3 3-I 2-CH3 — 0 Q1 C2F5 CF3 H 109-111 474 CH(CH3)CH2SOCH3 3-I 2-CH3 — 0 Q1 C2F5 CF3 H 475 CH(CH3)CH2SO2CH3 3-I 2-CH3 — 0 Q1 C2F5 CF3 H 103-115 476 C(CH3)2CH2SCH3 3-I 2-CH3 — 0 Q1 CF3 H Br 477 C(CH3)2CH2SOCH3 3-I 2-CH3 — 0 Q1 CF3 H Br 478 C(CH3)2CH2SO2CH3 3-I 2-CH3 — 0 Q1 CF3 H Br 479 CH(CH3)CH2SCH3 3-I 2-CH3 — 0 Q1 CF3 H Br 235-237 480 CH(CH3)CH2SOCH3 3-I 2-CH3 — 0 Q1 CF3 H Br 481 CH(CH3)CH2SO2CH3 3-I 2-CH3 — 0 Q1 CF3 H Br 201-209 482 C(CH3)2CH2SCH3 3-I 2-CH3 — 0 Q1 CF3 H H 483 C(CH3)2CH2SOCH3 3-I 2-CH3 — 0 Q1 CF3 H H 484 C(CH3)2CH2SO2CH3 3-I 2-CH3 — 0 Q1 CF3 H H 485 CH(CH3)CH2SCH3 3-I 2-CH3 — 0 Q1 CF3 H H 173-174 486 CH(CH3)CH2SOCH3 3-I 2-CH3 — 0 Q1 CF3 H H 487 CH(CH3)CH2SO2CH3 3-I 2-CH3 — 0 Q1 CF3 H H 107-109 488 C(CH3)2CH2SCH3 3-OSO2CH3 2-CH3 — 0 Q1 CF3 CF3 H 489 C(CH3)2CH2SOCH3 3-OSO2CH3 2-CH3 — 0 Q1 CF3 CF3 H 490 C(CH3)2CH2SO2CH3 3-OSO2CH3 2-CH3 — 0 Q1 CF3 CF3 H 491 CH(CH3)CH2SCH3 3-OSO2CH3 2-CH3 — 0 Q1 CF3 CF3 H 492 CH(CH3)CH2SCH3 3-OSO2CH3 2-CH3 — 0 Q1 CF3 CF3 H 175-177 (S)-isomer 493 CH(CH3)CH2SOCH3 3-OSO2CH3 2-CH3 — 0 Q1 CF3 CF3 H 494 CH(CH3)CH2SOCH3 3-OSO2CH3 2-CH3 — 0 Q1 CF3 CF3 H (S)-isomer 495 CH(CH3)CH2SO2CH3 3-OSO2CH3 2-CH3 — 0 Q1 CF3 CF3 H 496 CH(CH3)CH2SO2CH3 3-OSO2CH3 2-CH3 — 0 Q1 CF3 CF3 H (S)-isomer 497 C(CH3)2CH2SOCH3 3-I 2-CH3 — 0 Q5 C2F5 CF3 OH 498 C(CH3)2CH3SOCH3 3-I 2-CH3 — 0 Q5 C2F5 CF3 OH 499 C(CH3)2CH2SO2CH3 3-I 2-CH3 — 0 Q5 C2F5 CF3 OH 500 CH(CH3)CH2SCH3 3-I 2-CH3 — 0 Q5 C2F5 CF3 OH 101-106 501 CH(CH3)CH2SOCH3 3-I 2-CH3 — 0 Q5 C2F5 CF3 OH 502 CH(CH3)CH2SO2CH3 3-I 2-CH3 — 0 Q5 C2F5 CF3 OH 503 C(CH3)2CH2SCH3 3-I 2-CH3 — 0 Q11 CH2CF3 H CF3 504 C(CH3)2CH2SOCH3 3-I 2-CH3 — 0 Q11 CH2CF3 H CF3 505 C(CH3)2CH2SO2CH3 3-I 2-CH3 — 0 Q11 CH2CF3 H CF3 506 CH(CH3)CH2SCH3 3-I 2-CH3 — 0 Q11 CH2CF3 H CF3 106-118 507 CH(CH3)CH2SOCH3 3-I 2-CH3 — 0 Q11 CH2CF3 H CF3 508 CH(CH3)CH2SO2CH3 3-I 2-CH3 — 0 Q11 CH2CF3 H CF3 127-139 509 C(CH3)2CH2SCH3 3-I 2-CH3 — 0 Q11 CHF2 H CF3 510 C(CH3)2CH2SOCH3 3-I 2-CH3 — 0 Q11 CHF2 H CF3 511 C(CH3)2CH2SO2CH3 3-I 2-CH3 — 0 Q11 CHF2 H CF3 512 CH(CH3)CH2SCH3 3-I 2-CH3 — 0 Q11 CHF2 H CF3 138-144 513 CH(CH3)CH2SOCH3 3-I 2-CH3 — 0 Q11 CHF2 H CF3 514 CH(CH3)CH2SO2CH3 3-I 2-CH3 — 0 Q11 CHF2 H CF3 515 C(CH3)2CH2SCH3 3-I 2-CH3 — 0 Q12 CHF2 H OCHF2 516 C(CH3)2CH2SOCH3 3-I 2-CH3 — 0 Q12 CHF2 H OCHF2 517 C(CH3)2CH2SO2CH3 3-I 2-CH3 — 0 Q12 CHF2 H OCHF2 518 CH(CH3)CH2SCH3 3-I 2-CH3 — 0 Q12 CHF2 H OCHF2 83-89 519 CH(CH3)CH2SOCH3 3-I 2-CH3 — 0 Q12 CHF2 H OCHF2 520 CH(CH3)CH2SO2CH3 3-I 2-CH3 — 0 Q12 CHF2 H OCHF2 91-97 521 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 H C2F5 H *** 522 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 H C2F5 H *** 523 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 H C2F5 H *** 524 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 H C2F5 H 525 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H H 526 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H H 527 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 C2F5 H H 528 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 C2F5 H H 529 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 C2F5 H H *** 530 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 C2F5 H H *** 531 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C3F7-n H H 532 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C3F7-n H H *** (S)-isomer 533 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C3F7-n H H 534 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 C3F7-n H H *** 535 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 C3F7-n H H (S)-isomer 536 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 C3F7-n H H *** 537 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 C3F7-n H H *** 538 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 C3F7-n H H *** 539 CH(CH3)CH2SCH(CH3)2 3-I 2-CH3 CH2 1 Q1 CF3 CF3 H 81-83 (S)-isomer 540 CH(CH3)CH2SOCH(CH3)2 3-I 2-CH3 CH2 1 Q1 CF3 CF3 H (S)-isomer 541 CH(CH3)CH2SO2CH(CH3)2 3-I 2-CH3 CH2 1 Q1 CF3 CF3 H (S)-isomer 542 CH(CH3)CH2SCH(CH3)2 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H (S)-isomer 543 CH(CH3)CH2SCH3 3-NO2 2-CH3 CH2 1 Q1 CF3 CF3 H 161-171 (S)-isomer 544 CH(CH3)CH2SOCH3 3-NO2 2-CH3 CH2 1 Q1 CF3 CF3 H 227-229 (S)-isomer 545 CH(CH3)CH2SO2CH3 3-NO2 2-CH3 CH2 1 Q1 CF3 CF3 H 215-216 (S)-isomer 546 CH(CH3)CH2SCH3 3-NO2 2-CH3 CH2 1 Q2 CF3 CF3 — 175-179 (S)-isomer 547 CH(CH3)CH2SOCH3 3-NO2 2-CH3 CH2 1 Q2 CF3 CF3 — 225-228 (S)-isomer 548 CH(CH3)CH2SO2CH3 3-NO2 2-CH3 CH2 1 Q2 CF3 CF3 — 206-208 (S)-isomer 549 CH(CH3)CH2SCH3 3-F 2-CH3 CH2 1 Q1 CF3 CF3 H 66-68 (S)-isomer 550 CH(CH3)2 3-SCH3 2-CH3 CH2 1 Q1 CF3 CF3 H *** 551 CH(CH3)CH2SCH3 3-SCH3 2-CH3 CH2 1 Q1 CF3 CF3 H (S)-isomer 552 CH(CH3)CH2SCH3 3-SO2CH3 2-CH3 CH2 1 Q1 CF3 CF3 H *** (S)-isomer 553 CH(CH3)CH2SCH3 3-SCH2CH3 2-CH3 CH2 1 Q1 CF3 CF3 H *** (S)-isomer 554 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF3 CF3 I *** (S)-isomer 555 CH(CH3)CH2SCH3 3-I 2-CH3 CH(CH3) 1 Q1 CF3 H H 556 CH(CH3)CH2SCH3 3-I 2-CH3 CH(CH3) 1 Q1 CF3 H H 78-89 (S)-isomer 557 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH(CH3) 1 Q1 CF3 H H 150-152 (S)-isomer 558 C(CH3)2CH2SCH3 3-I 2-CH3 CH(CH3) 1 Q1 CF3 H H 79-86 559 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH(CH3) 1 Q1 CF3 CF3 H 80-91 (S)-isomer 560 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH(CH3) 1 Q1 CF3 CF3 H (S)-isomer 561 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH(CH3) 1 Q1 CF3 CF3 H 103-105 (S)-isomer 562 CH(CH3)CH2SCH3 3-I 2-CH3 CH(CH3) 1 Q1 CF3 CF3 H 84-89 (S)-isomer 563 CH(CH3)CH2SOCH3 3-I 2-CH3 CH(CH3) 1 Q1 CF3 CF3 H 177-179 (S)-isomer 564 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH(CH3) 1 Q1 CF3 CF3 H 101-105 (S)-isomer 565 C(CH3)2CH2SCH3 3-I 2-CH3 CH(CH3) 1 Q1 CF3 CF3 H 98-106 566 C(CH3)2CH2SOCH3 3-I 2-CH3 CH(CH3) 1 Q1 CF3 CF3 H 132-136 567 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH(CH3) 1 Q1 CF3 CF3 H 173-174 568 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH(CH3) 1 Q2 CF3 CF3 — 87-92 (S)-isomer 569 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH(CH3) 1 Q2 CF3 CF3 — *** (S)-isomer 570 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH(CH3) 1 Q2 CF3 CF3 — 91-95 (S)-isomer 571 CH(CH3)CH2SCH3 3-I 2-CH3 CH(CH3) 1 Q2 CF3 CF3 — 98-105 (S)-isomer 572 CH(CH3)CH2SOCH3 3-I 2-CH3 CH(CH3) 1 Q2 CF3 CF3 — 98-105 (S)-isomer 573 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH(CH3) 1 Q2 CF3 CF3 — 103-106 (S)-isomer 574 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH(CH3) 1 Q2 CF3 C2F5 — *** (S)-isomer 575 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH(CH3) 1 Q2 CF3 C2F5 — (S)-isomer 576 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH(CH3) 1 Q2 CF3 C2F5 — (S)-isomer 577 CH(CH3)CH2SCH3 3-I 2-CH3 CH(CH3) 1 Q2 CF3 C2F5 — (S)-isomer 578 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH(CH3) 1 Q2 C2F5 CF3 — 83-85 (S)-isomer 579 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH(CH3) 1 Q2 C2F5 CF3 — 121-124 (S)-isomer 580 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH(CH3) 1 Q2 C2F5 CF3 — 87-94 (S)-isomer 581 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH(CH3) 1 Q2 C2F5 C2F5 — (S)-isomer 582 CH(CH3)CH2SCH3 3-I 2-CH3 CH(CH3) 1 Q2 C2F5 C2F5 — (S)-isomer 583 CH(CH3)CH2SCH3 3-Cl 2-CH3 S 1 Q10 CF3 CF3 H (S)-isomer 584 CH(CH3)CH2SCH3 3-I 2-CH3 S 1 Q10 CF3 CF3 H (S)-isomer 585 CH(CH3)CH2SCH3 3-Cl 2-CH3 S 1 Q10 C2F5 C2F5 H (S)-isomer 586 CH(CH3)CH2SCH3 3-I 2-CH3 S 1 Q10 C2F5 C2F5 H (S)-isomer 587 CH(CH3)CH2SCH3 3-Cl 2-CH3 S 1 Q13 CF3 CF3 — (S)-isomer 588 CH(CH3)CH2SCH3 3-I 2-CH3 S 1 Q13 CF3 CF3 — 223-225 (S)-isomer 589 CH(CH3)CH2SCH3 3-I 2-CH3 SO2 1 Q13 CF3 CF3 — (S)-isomer 590 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q7 CH3 CHF2 — 591 C(CH3)2CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q7 CH3 CHF2 — 592 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q7 CH3 CHF2 — 99-101 593 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q7 CH3 CHF2 — 83-94 594 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q14 H COCF3 H *** (S)-isomer 595 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q14 I COCF3 H *** (S)-isomer 596 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q14 C2F5 COCF3 H *** (S)-isomer 597 C(CH3)2CH2SCH3 3-I 2-CH3 — 0 Q1 H H C3F7-n 598 C(CH3)2CH2SCH3 3-I 2-CH3 — 0 Q1 H H C4F9-n 599 C(CH3)2CH2SCH3 3-I 2-CH3 — 0 Q1 H H C6F13-n 600 C(CH3)2CH2SCH3 3-I 2-CH3 — 0 Q1 H H C8F17-n 601 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 H H C3F7-n (S)-isomer 602 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 H H C4F9-n 69-72 (S)-isomer 603 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 H H C6F13-n (S)-isomer 604 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 H H C8F17-n (S)-isomer 605 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 CH3 H C3F7-n 606 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 CH3 H C4F9-n 607 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 CH3 H C6F13-n 608 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 CF3 H 74-78 (S)-isomer 609 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 CF3 H 176-177 (S)-isomer 610 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 CF3 H 81-87 (S)-isomer 611 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 C2F5 CF3 H (S)-isomer 612 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 C2F5 CF3 H (S)-isomer 613 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 C2F5 CF3 H (S)-isomer 614 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C3F7-n CF3 H (S)-isomer 615 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 C3F7-n CF3 H (S)-isomer 616 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 C3F7-n CF3 H (S)-isomer 617 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 C3F7-n CF3 H (S)-isomer 618 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 C3F7-n CF3 H (S)-isomer 619 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 C3F7-n CF3 H (S)-isomer 620 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 C2F5 H 621 C(CH3)2CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 C2F5 H 622 C(CH3)2CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 C2F5 H 623 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 C2F5 C2F5 H 624 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q1 C2F5 C2F5 H 625 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 C2F5 C2F5 H 626 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 C2F5 H *** (S)-isomer 627 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 C2F5 H (S)-isomer 628 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 C2F5 H (S)-isomer 629 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 C2F5 C2F5 H (S)-isomer 630 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 C2F5 C2F5 H (S)-isomer 631 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 C2F5 C2F5 H (S)-isomer 632 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF3 H Cl *** (S)-isomer 633 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H Cl *** (S)-isomer 634 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C3F7-n H Cl *** (S)-isomer 635 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 H Br *** (S)-isomer 636 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 H I *** (S)-isomer 637 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 H C2F5 73-78 (S)-isomer 638 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 H C2F5 81-84 (S)-isomer 639 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 CF3 H C2F5 87-90 (S)-isomer 640 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF3 H C2F5 *** (S)-isomer 641 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 CF3 H C2F5 164-166 (S)-isomer 642 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 CF3 H C2F5 75-85 (S)-isomer 643 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 H C3F7-n 73-75 (S)-isomer 644 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF3 H C3F7-n 86-88 (S)-isomer 645 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 H C4F9-n 79-82 (S)-isomer 646 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 H C4F9-n 73-76 (S)-isomer 647 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 CF3 H C4F9-n 83-88 (S)-isomer 648 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF3 H C4F9-n 88-92 (S)-isomer 649 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 CF3 H C4F9-n 84-90 (S)-isomer 650 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 CF3 H C4F9-n 75-78 (S)-isomer 651 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C2F5 *** (S)-isomer 652 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C2F5 124-125 (S)-isomer 653 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C2F5 88-91 (S)-isomer 654 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 C2F5 H C2F5 *** (S)-isomer 655 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 C2F5 H C2F5 87-92 (S)-isomer 656 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 C2F5 H C2F5 100-107 (S)-isomer 657 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C3F7-n 64-65 (S)-isomer 658 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C3F7-n *** (S)-isomer 659 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C3F7-n 78-81 (S)-isomer 660 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 C2F5 H C3F7-n *** (S)-isomer 661 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 C2F5 H C3F7-n 83-85 (S)-isomer 662 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 C2F5 H C3F7-n 92-96 (S)-isomer 663 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C4F9-n 72-74 (S)-isomer 664 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 C2F5 H C4F9-n 84-88 (S)-isomer 665 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C3F7-n H C2F5 78-85 (S)-isomer 666 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 C3F7-n H C2F5 78-85 (S)-isomer 667 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C3F7-n H C3F7-n 70-74 (S)-isomer 668 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 C3F7-n H C3F7-n 73-77 (S)-isomer 669 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 C3F7-n H C3F7-n 77-82 (S)-isomer 670 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 C3F7-n H C3F7-n 86-90 (S)-isomer 671 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 C3F7-n H C3F7-n 81-84 (S)-isomer 672 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 C3F7-n H C3F7-n 147-148 (S)-isomer 673 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 H C2F5 CF3 (S)-isomer 674 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 H C2F5 CF3 (S)-isomer 675 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 H C2F5 C2F5 *** (S)-isomer 676 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 H C2F5 C2F5 (S)-isomer 677 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q2 C2F5 C2F5 — 678 C(CH3)2CH2SOCH3 3-Cl 2-CH3 CH2 1 Q2 C2F5 C2F5 — 679 C(CH3)2CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q2 C2F5 C2F5 — 680 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q2 C2F5 C2F5 — 681 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q2 C2F5 C2F5 — *** (S)-isomer 682 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q2 C2F5 C2F5 — 683 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q2 C2F5 C2F5 — 162-164 (S)-isomer 684 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q2 C2F5 C2F5 — 685 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q2 C2F5 C2F5 — 103-106 (S)-isomer 686 CH(CH3)CH2SC2H5 3-Cl 2-CH3 CH2 1 Q2 C2F5 C2F5 — (S)-isomer 687 CH(CH3)CH2SOC2H5 3-Cl 2-CH3 CH2 1 Q2 C2F5 C2F5 — (S)-isomer 688 CH(CH3)CH2SO2C2H5 3-Cl 2-CH3 CH2 1 Q2 C2F5 C2F5 — (S)-isomer 689 C(CH3)2CH2SCH3 3-Br 2-CH3 CH2 1 Q2 C2F5 C2F5 — 690 C(CH3)2CH2SOCH3 3-Br 2-CH3 CH2 1 Q2 C2F5 C2F5 — 691 C(CH3)2CH2SO2CH3 3-Br 2-CH3 CH2 1 Q2 C2F5 C2F5 — 692 CH(CH3)CH2SCH3 3-Br 2-CH3 CH2 1 Q2 C2F5 C2F5 — 693 CH(CH3)CH2SCH3 3-Br 2-CH3 CH2 1 Q2 C2F5 C2F5 — (S)-isomer 694 CH(CH3)CH2SOCH3 3-Br 2-CH3 CH2 1 Q2 C2F5 C2F5 — 695 CH(CH3)CH2SOCH3 3-Br 2-CH3 CH2 1 Q2 C2F5 C2F5 — (S)-isomer 696 CH(CH3)CH2SO2CH3 3-Br 2-CH3 CH2 1 Q2 C2F5 C2F5 — 697 CH(CH3)CH2SO2CH3 3-Br 2-CH3 CH2 1 Q2 C2F5 C2F5 — (S)-isomer 698 CH(CH3)CH2SC2H5 3-Br 2-CH3 CH2 1 Q2 C2F5 C2F5 — (S)-isomer 699 CH(CH3)CH2SOC2H5 3-Br 2-CH3 CH2 1 Q2 C2F5 C2F5 — (S)-isomer 700 CH(CH3)CH2SO2C2H5 3-Br 2-CH3 CH2 1 Q2 C2F5 C2F5 — (S)-isomer 701 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q2 C2F5 C2F5 — 702 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q2 C2F5 C2F5 — 703 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q2 C2F5 C2F5 — 704 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q2 C2F5 C2F5 — 705 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q2 C2F5 C2F5 — (S)-isomer 706 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q2 C2F5 C2F5 — 707 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q2 C2F5 C2F5 — (S)-isomer 708 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q2 C2F5 C2F5 — 709 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q2 C2F5 C2F5 — (S)-isomer 710 CH(CH3)CH2SC2H5 3-I 2-CH3 CH2 1 Q2 C2F5 C2F5 — (S)-isomer 711 CH(CH3)CH2SOC2H5 3-I 2-CH3 CH2 1 Q2 C2F5 C2F5 — (S)-isomer 712 CH(CH3)CH2SO2C2H5 3-I 2-CH3 CH2 1 Q2 C2F5 C2F5 — (S)-isomer 713 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q2 C3F7-n CF3 — 714 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q2 C3F7-n CF3 — *** (S)-isomer 715 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q2 C3F7-n CF3 — (S)-isomer 716 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q2 C3F7-n C2F5 — (S)-isomer 717 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q2 C3F7-n C2F5 — (S)-isomer 718 C(CH3)2CH2SCH3 3-F 2-CH3 CH2 1 Q1 CF3 CF3 H 719 C(CH3)2CH2SOCH3 3-F 2-CH3 CH2 1 Q1 CF3 CF3 H 720 C(CH3)2CH2SO2CH3 3-F 2-CH3 CH2 1 Q1 CF3 CF3 H 721 CH(CH3)CH2SOCH3 3-F 2-CH3 CH2 1 Q1 CF3 CF3 H (S)-isomer 722 CH(CH3)CH2SO2CH3 3-F 2-CH3 CH2 1 Q1 CF3 CF3 H (S)-isomer 723 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 H H C4F9-n 63-69 (S)-isomer 724 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 H H C4F9-n 95-97 (S)-isomer 725 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 H CF3 C3F7-n 76-81 (S)-isomer 726 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 H CF3 C3F7-n *** (S)-isomer 727 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 H CF3 C3F7-n *** (S)-isomer 728 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 H C2F5 C2F5 68-72 (S)-isomer 729 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 H C2F5 C2F5 *** (S)-isomer 730 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CHF2 CHF2 H *** (S)-isomer 731 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 H CF3 732 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 H CF3 (S)-isomer 733 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 H CF2CHF2 734 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 H CF2CHF2 (S)-isomer 735 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 H C4F9-n 736 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 H C4F9-n 737 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 H C6F13-n 78-82 (S)-isomer 738 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 H C8F17-n 79-82 (S)-isomer 739 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 CF3 (S)-isomer 740 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF2CHF2 H C2F5 741 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF2CHF2 H C2F5 *** (S)-isomer 742 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 CF2CHF2 H C2F5 64-67 (S)-isomer 743 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 CF2CHF2 H C2F5 83-89 (S)-isomer 744 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H CF3 745 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H CF3 75-80 (S)-isomer 746 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H CF2CHF2 (S)-isomer 747 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H CF2CHF2 (S)-isomer 748 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H CF2CHF2 (S)-isomer 749 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C2F5 750 C(CH3)2CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C2F5 751 C(CH3)2CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C2F5 752 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C2F5 753 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C2F5 754 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C2F5 755 CH(CH3)CH2SCH3 3-Cl 2-CH3 — 0 Q1 C2F5 H C2F5 95-100 (S)-isomer 756 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH(CH3) 1 Q1 C2F5 H C2F5 (S)-isomer 757 CH(CH3)CH2SOCH3 3-Cl 2-CH3 — 0 Q1 C2F5 H C2F5 89-94 (S)-isomer 758 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH(CH3) 1 Q1 C2F5 H C2F5 (S)-isomer 759 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 — 0 Q1 C2F5 H C2F5 195-195 (S)-isomer 760 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH(CH3) 1 Q1 C2F5 H C2F5 (S)-isomer 761 CH(CH3)CH2SC2H5 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C2F5 70-74 (S)-isomer 762 CH(CH3)CH2SOC2H5 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C2F5 79-84 (S)-isomer 763 CH(CH3)CH2SO2C2H5 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C2F5 185-188 (S)-isomer 764 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH(CH3) 1 Q1 C2F5 H C3F7-n 765 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C3F7-n 766 C(CH3)2CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C3F7-n 767 C(CH3)2CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C3F7-n 768 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C3F7-n 769 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C4F9-n 770 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C4F9 771 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C4F9-n 81-85 (S)-isomer 772 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 H C4F9-n (S)-isomer 773 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 F CF3 774 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 F CF3 775 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 F CF3 142-146 (S)-isomer 776 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 F CF3 (S)-isomer 777 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 F CF3 (S)-isomer 778 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 CH3 C2F5 *** (S)-isomer 779 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C2F5 C2F5 C2F5 (S)-isomer 780 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C3F7-n H C2F5 781 C(CH3)2CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 C3F7-n H C2F5 782 C(CH3)2CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 C3F7-n H C2F5 783 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C3F7-n H C2F5 784 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 C3F7-n H C2F5 81-83 (S)-isomer 785 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 C3F7-n H C2F5 85-90 (S)-isomer 786 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH(CH3) 1 Q1 C3F-n H C3F7-n 787 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C3F-n H C3F7-n 788 C(CH3)2CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 C3F-n H C3F7-n 789 C(CH3)2CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 C3F-n H C3F7-n 790 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C3F-n H C3F7-n 791 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 C3F-n H C3F7-n 792 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 C3F-n H C3F7-n 793 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 C3F7-n C3F7-n H 74-78 (S)-isomer 794 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 C3F7-n C3F7-n H 72-76 (S)-isomer 795 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 C3F7-n C3F7-n H 149-150 (S)-isomer 796 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q2 CHFCF3 CF3 — 66-69 (S)-isomer 797 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q2 CHFCF3 CF3 — 80-85 (S)-isomer 798 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q2 CHFCF3 CF3 — 81-86 (S)-isomer 799 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q2 CF2CHF2 CF2CHF2 — *** (S)-isomer 800 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q2 CF2CHF2 CF2CHF2 — 159-163 (S)-isomer 801 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q2 CF2CHF2 CF2CHF2 — 77-83 (S)-isomer 802 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q2 C3F7-n C3F7-n — 803 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q2 C4F9-n H — 218-210 (S)-isomer 804 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q2 SC3F7-n CF3 — 73-76 (S)-isomer 805 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q6 CF3 CF3 CF3 (S)-isomer 806 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q6 CF3 CF3 CF3 (S)-isomer 807 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q6 CF3 CF3 CF3 (S)-isomer 808 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q9 CF3 CF3 — 809 C(CH3)2CH2SOCH3 3-Cl 2-CH3 CH2 1 Q9 CF3 CF3 — 810 C(CH3)2CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q9 CF3 CF3 — 811 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q9 CF3 CF3 — 812 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q9 CF3 CF3 — 813 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q9 CF3 CF3 — 814 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q9 CF3 CF3 — (S)-isomer 815 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q9 CF3 CF3 — (S)-isomer 816 CH(CH3)CH2SC2H5 3-Cl 2-CH3 CH2 1 Q9 CF3 CF3 — (S)-isomer 817 CH(CH3)CH2SOC2H5 3-Cl 2-CH3 CH2 1 Q9 CF3 CF3 — (S)-isomer 818 CH(CH3)CH2SO2C2H5 3-Cl 2-CH3 CH2 1 Q9 CF3 CF3 — (S)-isomer 819 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q9 C2F5 CF3 — 820 C(CH3)2CH2SOCH3 3-Cl 2-CH3 CH2 1 Q9 C2F5 CF3 — 821 C(CH3)2CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q9 C2F5 CF3 — 822 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q9 C2F5 CF3 — 823 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q9 C2F5 CF3 — 824 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q9 C2F5 CF3 — 825 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q9 C2F5 CF3 — (S)-isomer 826 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q9 C2F5 CF3 — (S)-isomer 827 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q9 C2F5 CF3 — (S)-isomer 828 CH(CH3)CH2SC2H5 3-Cl 2-CH3 CH2 1 Q9 C2F5 CF3 — (S)-isomer 829 CH(CH3)CH2SOC2H5 3-Cl 2-CH3 CH2 1 Q9 C2F5 CF3 — (S)-isomer 830 CH(CH3)CH2SO2C2H5 3-Cl 2-CH3 CH2 1 Q9 C2F5 CF3 — (S)-isomer 831 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q9 C2F5 C2F5 — 832 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q9 C2F5 C2F5 — 833 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q9 C2F5 C2F5 — (S)-isomer 834 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q9 C3F7-n CF3 — 835 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q9 C3F7-n CF3 — (S)-isomer 836 CH(CH3)CH2SCH3 3-Cl 2-CH3 S 1 Q18 CF3 CH3 — (S)-isomer 837 CH(CH3)CH2SCH3 3-Cl 2-CH3 — 0 Q19 CF3 CH3 — (S)-isomer 838 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q17 CF3 H — 839 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q15 H C2F5 — 840 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q15 H C2F5 — 71-75 (S)-isomer 841 CH(CH3)CH2SCH3 3-Cl 2-CH3 — 0 Q20 CF3 — — (S)-isomer 842 CH(CH3)CH2SCH3 3-Cl 2-CH3 — 0 Q16 C2F5 — — 843 CH(CH3)CH2SCH3 3-Cl 2-CH3 — 0 Q16 C3F7-n — — 844 C(CH3)2CH2SCH3 3-Br 2-CH3 CH2 1 Q1 CF3 H C2F5 845 C(CH3)2CH2SCH3 3-Br 2-CH3 CH2 1 Q1 CF3 H C4F9-n 846 CH(CH3)CH2SCH3 3-Br 2-CH3 CH2 1 Q1 CF3 H C4F9-n 847 C(CH3)2CH2SCH3 3-Br 2-CH3 CH2 1 Q1 CF2CHF2 H C2F5 848 C(CH3)2CH2SCH3 3-Br 2-CH3 CH2 1 Q1 C2F5 H C2F5 849 C(CH3)2CH2SOCH3 3-Br 2-CH3 CH2 1 Q1 C2F5 H C2F5 850 C(CH3)2CH2SO2CH3 3-Br 2-CH3 CH2 1 Q1 C2F5 H C2F5 851 CH(CH3)CH2SCH3 3-Br 2-CH3 CH2 1 Q1 C2F5 H C2F5 852 CH(CH3)CH2SOCH3 3-Br 2-CH3 CH2 1 Q1 C2F5 H C2F5 853 CH(CH3)CH2SO2CH3 3-Br 2-CH3 CH2 1 Q1 C2F5 H C2F5 854 C(CH3)2CH2SCH3 3-Br 2-CH3 CH2 1 Q1 C2F5 H C4F9-n 855 CH(CH3)CH2SCH3 3-Br 2-CH3 CH2 1 Q1 C2F5 H C4F9-n 856 CH(CH3)CH2SCH3 3-Br 2-CH3 CH2 1 Q1 C3F7-n H C2F5 857 C(CH3)2CH2SCH3 3-Br 2-CH3 CH2 1 Q1 C3F7-n H C3F7-n 858 C(CH3)2CH2SOCH3 3-Br 2-CH3 CH2 1 Q1 C3F7-n H C3F7-n 859 CH(CH3)2CH2SO2CH3 3-Br 2-CH3 CH2 1 Q1 C3F7-n H C3F7-n 860 CH(CH3)CH2SCH3 3-Br 2-CH3 CH2 1 Q1 C3F7-n H C3F7-n 861 CH(CH3)CH2SOCH3 3-Br 2-CH3 CH2 1 Q1 C3F7-n H C3F7-n 862 CH(CH3)CH2SO2CH3 3-Br 2-CH3 CH2 1 Q1 C3F7-n H C3F7-n 863 C(CH3)2CH2SCH3 3-Br 2-CH3 CH2 1 Q9 CF3 CF3 — 864 C(CH3)2CH2SOCH3 3-Br 2-CH3 CH2 1 Q9 CF3 CF3 — 865 C(CH3)2CH2SO2CH3 3-Br 2-CH3 CH2 1 Q9 CF3 CF3 — 866 CH(CH3)CH2SCH3 3-Br 2-CH3 CH2 1 Q9 CF3 CF3 — 867 CH(CH3)CH2SOCH3 3-Br 2-CH3 CH2 1 Q9 CF3 CF3 — 868 CH(CH3)CH2SO2CH3 3-Br 2-CH3 CH2 1 Q9 CF3 CF3 — 869 C(CH3)2CH2SCH3 3-Br 2-CH3 CH2 1 Q9 C2F5 CF3 — 870 C(CH3)2CH2SOCH3 3-Br 2-CH3 CH2 1 Q9 C2F5 CF3 — 871 C(CH3)2CH2SO2CH3 3-Br 2-CH3 CH2 1 Q9 C2F5 CF3 — 872 CH(CH3)CH2SCH3 3-Br 2-CH3 CH2 1 Q9 C2F5 CF3 — 873 CH(CH3)CH2SOCH3 3-Br 2-CH3 CH2 1 Q9 C2F5 CF3 — 874 CH(CH3)CH2SO2CH3 3-Br 2-CH3 CH2 1 Q9 C2F5 CF3 — 875 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 H H C4F9-n 80-85 (S)-isomer 876 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 H H C4F9-n 160-162 (S)-isomer 877 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 H H C4F9-n 85-89 (S)-isomer 878 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 CHF2 CHF2 H *** (S)-isomer 879 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF3 H CF3 880 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF3 H CF2CHF2 881 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF3 H CF2CHF2 (S)-isomer 882 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF3 H C2F5 883 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF3 H C2F5 884 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF3 H C4F9-n 885 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF3 H C4F9-n 886 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF3 CF3 CF3 887 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF3 CF3 CF3 888 C(CH3)2CH2SCH3 3-I 2-CH3 CH(CH3) 1 Q1 CF2CHF2 H C2F5 889 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF2CHF2 H C2F5 890 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF2CHF2 H C2F5 (S)-isomer 891 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 CF2CHF2 H C2F5 (S)-isomer 892 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 CF2CHF2 H C2F5 (S)-isomer 893 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 C2F5 H CF3 894 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 C2F5 H CF2CHF2 (S)-isomer 895 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 C2F5 H CF2CHF2 (S)-isomer 896 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 C2F5 H CF2CHF2 (S)-isomer 897 C(CH3)2CH2SCH3 3-I 2-CH3 CH(CH3) 1 Q1 C2F5 H C2F5 898 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 C2F5 H C2F5 899 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q1 C2F5 H C2F5 900 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 C2F5 H C2F5 901 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 C2F5 H C2F5 902 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 C2F5 H C2F5 903 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 C2F5 H C2F5 904 CH(CH3)CH2SC2H5 3-I 2-CH3 CH2 1 Q1 C2F5 H C2F5 (S)-isomer 905 CH(CH3)CH2SOC2H5 3-I 2-CH3 CH2 1 Q1 C2F5 H C2F5 (S)-isomer 906 CH(CH3)CH2SO2C2H5 3-I 2-CH3 CH2 1 Q1 C2F5 H C2F5 (S)-isomer 907 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 C2F5 H C3F7-n 908 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q1 C2F5 H C3F7-n 909 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 C2F5 H C3F7-n 910 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 C2F5 H C3F7-n 911 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 C2F5 H C4F9-n 912 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 C2F5 H C4F9-n 913 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 C2F5 H C4F9-n 90-96 (S)-isomer 914 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 C2F5 H C4F9-n 92-97 (S)-isomer 915 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 C2F5 F CF3 916 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 C3F7-n H C2F5 917 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 C3F7-n H C2F5 918 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 C3F7-n H C2F5 919 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 C3F7-n H C2F5 920 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 C3F7-n H C2F5 89-96 (S)-isomer 921 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 C3F7-n H C2F5 92-96 (S)-isomer 922 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 C3F7-n H C3F7-n 923 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q1 C3F7-n H C3F7-n 924 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 C3F7-n H C3F7-n 925 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q1 C3F7-n H C3F7-n 926 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q1 C3F7-n H C3F7-n 927 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 C3F7-n H C3F7-n 928 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q2 C3F7-n C3F7-n — 929 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q6 CF3 CF3 CF3 (S)-isomer 930 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q6 CF3 CF3 CF3 (S)-isomer 931 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q6 CF3 CF3 CF3 (S)-isomer 932 C(CH3)2CH2SCH3 3-I 2-CH3 CH(CH3) 1 Q9 CF3 CF3 — 933 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q9 CF3 CF3 — 934 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q9 CF3 CF3 — 935 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q9 CF3 CF3 — 936 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q9 CF3 CF3 — (S)-isomer 937 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q9 CF3 CF3 — (S)-isomer 938 CH(CH3)CH2SC2H5 3-I 2-CH3 CH2 1 Q9 CF3 CF3 — (S)-isomer 939 CH(CH3)CH2SOC2H5 3-I 2-CH3 CH2 1 Q9 CF3 CF3 — (S)-isomer 940 CH(CH3)CH2SO2C2H5 3-I 2-CH3 CH2 1 Q9 CF3 CF3 — (S)-isomer 941 C(CH3)2CH2SCH3 3-I 2-CH3 CH(CH3) 1 Q9 C2F5 CF3 — 942 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q9 C2F5 CF3 — 943 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q9 C2F5 CF3 — 944 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q9 C2F5 CF3 — 945 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q9 C2F5 CF3 — 946 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q9 C2F5 CF3 — 947 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q9 C2F5 CF3 — 948 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q9 C2F5 CF3 — (S)-isomer 949 CH(CH3)CH2SOCH3 3-I 2-CH3 CH2 1 Q9 C2F5 CF3 — (S)-isomer 950 CH(CH3)CH2SO2CH3 3-I 2-CH3 CH2 1 Q9 C2F5 CF3 — (S)-isomer 951 CH(CH3)CH2SC2H5 3-I 2-CH3 CH2 1 Q9 C2F5 CF3 — (S)-isomer 952 CH(CH3)CH2SOC2H5 3-I 2-CH3 CH2 1 Q9 C2F5 CF3 — (S)-isomer 953 CH(CH3)CH2SO2C2H5 3-I 2-CH3 CH2 1 Q9 C2F5 CF3 — (S)-isomer 954 C(CH3)2CH2SCH3 3-I 2-CH3 CH(CH3) 1 Q9 C2F5 C2F5 — 955 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q9 C2F5 C2F5 — 956 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q9 C2F5 C2F5 — 957 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q9 C2F5 C2F5 — (S)-isomer 958 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q9 C3F7-n CF3 — 959 CH(CH3)CH2SCH3 3-I 2-CH3 CH2 1 Q9 C3F7-n CF3 — (S)-isomer 960 C(CH3)2CH2SCH3 3-I 2-CH3 S 1 Q18 CF3 CH3 — 961 C(CH3)2CH2SCH3 3-I 2-CH3 — 0 Q19 CF3 CH3 — 962 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q17 CF3 H — 963 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q15 H C2F5 — 964 C(CH3)2CH2SCH3 3-I 2-CH3 — 0 Q20 CF3 — — 965 CH(CH3)CH2SCH3 3-I 2-CH3 — 0 Q16 CF3 — — 966 C(CH3)2CH2SCH3 3-Cl 2-F CH2 1 Q1 CF3 CF3 H 967 C(CH3)2CH2SOCH3 3-Cl 2-F CH2 1 Q1 CF3 CF3 H 968 C(CH3)2CH2SO2CH3 3-Cl 2-F CH2 1 Q1 CF3 CF3 H 969 C(CH3)2CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H 970 C(CH3)2CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H 971 C(CH3)2CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H 972 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H 973 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H 974 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H 975 CH(CH3)CH2SCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H (S)-isomer 976 CH(CH3)CH2SOCH3 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H (S)-isomer 977 CH(CH3)CH2SO2CH3 3-Cl 2-CH3 CH2 1 Q1 CF3 CF3 H (S)-isomer 978 CH(CH3)CH2SCH3 3-Cl 2-Cl CH2 1 Q1 C2F5 CF3 H (S)-isomer 979 CH(CH3)CH2SOCH3 3-Cl 2-Cl CH2 1 Q1 C2F5 CF3 H (S)-isomer 980 CH(CH3)CH2SO2CH3 3-Cl 2-Cl CH2 1 Q1 C2F5 CF3 H (S)-isomer 981 C(CH3)2CH2SCH3 3-Cl 2-Cl CH2 1 Q1 CF3 H C2F5 982 C(CH3)2CH2SCH3 3-Cl 2-Cl CH2 1 Q1 CF3 H C3F7-n 983 C(CH3)2CH2SCH3 3-Cl 2-Cl CH2 1 Q1 CF3 H C4F9-n 984 C(CH3)2CH2SCH3 3-Cl 2-Cl CH2 1 Q1 CF3 H C6F13-n 985 CH(CH3)CH2SCH3 3-Cl 2-Cl CH2 1 Q1 C2F5 H C2F5 (S)-isomer 986 CH(CH3)CH2SOCH3 3-Cl 2-Cl CH2 1 Q1 C2F5 H C2F5 (S)-isomer 987 CH(CH3)CH2SO2CH3 3-Cl 2-Cl CH2 1 Q1 C2F5 H C2F5 (S)-isomer 988 CH(CH3)CH2SCH3 3-Cl 2-Cl CH2 1 Q1 C2F5 H C3F7-n (S)-isomer 989 CH(CH3)CH2SOCH3 3-Cl 2-Cl CH2 1 Q1 C2F5 H C3F7-n (S)-isomer 990 CH(CH3)CH2SO2CH3 3-Cl 2-Cl CH2 1 Q1 C2F5 H C3F7-n (S)-isomer 991 CH(CH3)CH2SCH3 3-Cl 2-Cl CH2 1 Q2 CF3 CF3 — (S)-isomer 992 CH(CH3)CH2SCH3 3-Cl 2-Cl CH2 1 Q2 C2F5 CF3 — (S)-isomer 993 CH(CH3)CH2SCH3 3-Cl 2-Cl CH2 1 Q9 CF3 CF3 — (S)-isomer 994 CH(CH3)CH2SCH3 3-Cl 2-Cl CH2 1 Q9 C2F5 CF3 — (S)-isomer 995 C(CH3)2CH2SCH3 3-I 2-F CH2 1 Q1 CF3 CF3 H *** 996 C(CH3)2CH2SOCH3 3-I 2-F CH2 1 Q1 CF3 CF3 H 997 C(CH3)2CH2SO2CH3 3-I 2-F CH2 1 Q1 CF3 CF3 H 113-115 998 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 CF3 CF3 H 157-159 999 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q1 CF3 CF3 H 1000 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 CF3 CF3 H 129-134 1001 C(CH3)2CH2SCH3 3-I 2-CH3 CH2 1 Q1 C2F5 CF3 H 1002 C(CH3)2CH2SOCH3 3-I 2-CH3 CH2 1 Q1 C2F5 CF3 H 1003 C(CH3)2CH2SO2CH3 3-I 2-CH3 CH2 1 Q1 C2F5 CF3 H 1004 C(CH3)2CH2SCH3 3-I 2-Cl CH2 1 Q1 C2F5 C2F5 H 1005 C(CH3)2CH2SOCH3 3-I 2-Cl CH2 1 Q1 C2F5 C2F5 H 1006 C(CH3)2CH2SO2CH3 3-I 2-Cl CH2 1 Q1 C2F5 C2F5 H 1007 CH(CH3)CH2SCH3 3-I 2-Cl CH2 1 Q1 C2F5 H C2F5 (S)-isomer 1008 CH(CH3)CH2SCH3 3-I 2-Cl CH2 1 Q1 C2F5 H C3F7-n (S)-isomer 1009 CH(CH3)CH2SCH3 3-I 2-Cl CH2 1 Q1 C2F5 H C4F9-n (S)-isomer 1010 CH(CH3)CH2SCH3 3-I 2-Cl CH2 1 Q1 C2F5 H C6F13-n (S)-isomer 1011 CH(CH3)CH2SCH3 3-I 2-Cl CH2 1 Q2 CF3 CF3 — (S)-isomer 1012 CH(CH3)CH2SCH3 3-I 2-Cl CH2 1 Q2 C2F5 CF3 — (S)-isomer 1013 CH(CH3)CH2SCH3 3-I 2-Cl CH2 1 Q2 C2F5 C2F5 — (S)-isomer 1014 CH(CH3)CH2SCH3 3-I 2-Cl CH2 1 Q2 C3F7-n CF3 — (S)-isomer indicates data missing or illegible when filed -
TABLE 2 No. 1 1H-NMR (CDCl3, ppm): 1.4 (6H, s), 2.0 (3H, s), 2.3 (3H, s), 2.9 (2H, s), 5.4 (2H, s), 6.2 (1H, s), 6.9 (1H, s), 7.3-8.7 (8H, m) 3 1H-NMR (CDCl3, ppm): 1.5 (6H, s), 2.2 (3H, s), 2.6 (3H, s), 3.7 (2H, s), 5.4 (2H, s), 6.4 (1H, s), 6.9 (1H, s), 7.3-8.2 (8H, m) 8 1H-NMR (CDCl3, ppm): 1.4 (6H, s), 2.0 (3H, s), 2.3 (3H, s), 2.9 (2H, s), 5.4 (2H, s), 6.1 (1H, s), 6.9 (1H, s), 7.3-8.4 (7H, m) 11 1H-NMR (CDCl3, ppm): 1.2 (3H, d), 1.9 (3H, s), 2.3 (3H, s), 2.7 (2H, dd), 4.2 (1H, m), 5.4 (2H, s), 6.4 (1H, d), 6.9 (1H, s), 7.3-8.4 (7H, m) 15 1H-NMR (CDCl3, ppm): 1.3 (3H, d), 2.2 (3H, s), 2.8 (3H, s), 3.2 (2H, m), 4.6 (1H, m), 5.4 (2H, s), 6.4 (1H, d), 6.9-8.4 (8H, m) 47 1H-NMR (CDCl3, ppm): 1.6 (6H, s), 2.3 (3H, s), 2.5 (3H, s), 3.5 (2H, s), 5.4 (2H, s), 6.6 (1H, s), 6.9 (1H, s), 7.3-8.2 (7H, m) 52 1H-NMR (CDCl3, ppm): 1.4 (3H, d), 2.2 (3H, s), 2.7 (3H, s), 3.2 (2H, m), 4.4 (1H, m), 5.4 (2H, s), 6.9-8.2 (9H, m) 81 1H-NMR (CDCl3, ppm): 1.1 (6H, d), 2.2 (3H, s), 4.2 (1H, m), 5.3 (2H, s), 5.9 (1H, d), 6.9-8.2 (8H, m) 83 1H-NMR (CDCl3, ppm): 1.57 (3H, s), 1.60 (3H, s), 2.20 (3H, s), 2.30 (3H, s), 2.93 (2H, dd), 5.43 (2H, s), 6.57 (1H, s), 6.90 (1H, s), 7.0-8.2 (7H, m) 85 1H-NMR (CDCl3, ppm): 1.2 (3H, d), 1.8 (3H, s), 2.2 (3H, s), 2.6 (2H, dd), 4.2 (1H, m), 5.3 (2H, s), 6.5 (1H, d), 6.9 (1H, s), 7.3-8.4 (7H, m) 89 1H-NMR (CDCl3, ppm): 1.4 (3H, d), 2.2 (3H, s), 2.7 (3H, s), 3.2 (2H, m), 4.5 (1H, m), 5.3 (2H, s), 6.6 (1H, d), 6.9-7.9 (8H, m) 94 1H-NMR (CDCl3, ppm): 1.57 (3H, s), 1.60 (3H, s), 2.20 (3H, s), 2.30 (3H, s), 2.93 (2H, dd), 5.43 (2H, s), 6.57 (1H, s), 6.90 (1H, s), 7.0-8.2 (7H, m) 96 1H-NMR (CDCl3, ppm): 1.63 (6H, s), 2.27 (3H, s), 2.50 (3H, s), 3.47 (2H, s), 5.30 (2H, s), 6.23 (1H, s), 6.57 (1H, s), 7.0-8.1 (8H, m) 97 1H-NMR (CDCl3, ppm): 1.27 (3H, d), 1.93 (3H, s), 2.30 (3H, s), 2.63 (2H, m), 4.33 (1H, m), 5.37 (2H, s), 6.07 (1H, m), 6.60 (1H, s), 6.9-8.2 (8H, m) 99 1H-NMR (CDCl3, ppm): 1.50 (3H, d), 2.27 (3H, s), 2.70 (3H, s), 3.0-3.5 (2H, m), 4.60 (1H, m), 5.37 (2H, s), 6.5-8.0 (10H, m) 103 1H-NMR (CDCl3, ppm): 1.27 (3H, d), 1.93 (3H, s), 2.30 (3H, s), 2.60 (2H, m), 4.33 (1H, m), 5.20 (2H, s), 6.17 (1H, s), 6.47 (1H, t), 7.1-8.3 (8H, m) 107 1H-NMR (CDCl3, ppm): 1.50 (3H, d), 1.93 (3H, s), 2.30 (3H, s), 2.60 (2H, m), 4.33 (1H, m), 5.20 (2H, s), 6.17 (1H, s), 6.47 (1H, t), 6.67 (1H, m), 7.0-8.1 (7H, m) 116 1H-NMR (CDCl3, ppm): 1.2 (3H, d), 1.9 (3H, s), 2.2 (3H, s), 2.6 (2H, dd), 4.2 (1H, m), 5.2 (2H, s), 6.4 (1H, d), 7.0-8.3 (9H, m) 149 1H-NMR (CDCl3, ppm): 1.34 (6H, s), 1.95 (3H, s), 2.33 (3H, s), 2.86 (2H, s), 5.48 (2H, s), 6.11 (1H, s), 7.56-7.00 (4H, m), 7.84-7.72 (1H, m), 8.23 (1H, d), 8.49 (1H, s) 153 1H-NMR (CDCl3, ppm): 1.22 (3H, d), 2.05 (3H, s), 2.30 (3H, s), 2.61-2.53 (2H, m), 4.40-4.29 (1H, m), 5.44 (2H, s), 6.19 (1H, d), 7.17 (2H, t), 7.54-7.48 (2H, m), 7.73 (1H, d), 8.15 (1H, d), 8.44 (1H, s) 180 1H-NMR (CDCl3, ppm): 1.3 (3H, d), 2.2 (3H, s), 2.3 (3H, s), 2.8 (2H, d), 4.5 (1H, m), 5.4 (2H, s), 7.1-8.3 (8H, m) 242 1H-NMR (CDCl3, ppm): 1.4 (3H, d), 2.2 (3H, s), 2.8 (3H, s), 3.2 (2H, m), 4.6 (1H, m), 5.5 (2H, s), 6.2-8.2 (9H, m) 251 1H-NMR (CDCl3, ppm): 1.25 (3H, d), 1.95 (3H, s), 2.28 (3H, s), 2.63-2.51 (2H, m), 3.28 (3H, s), 4.36-4.26 (1H, m), 5.43 (2H, s), 6.38 (1H, d, J = 9.3 Hz), 7.39-7.16 (2H, m), 7.62-7.53 (2H, m), 7.81-7.74 (1H, m), 8.38 (1H, s) 271 1H-NMR (CDCl3, ppm): 1.47 (6H, s), 2.00 (3H, s), 2.30 (3H, s), 2.83 (2H, s), 3.30 (1H, m), 4.2-4.6 (4H, m), 6.07 (1H, s), 7.1-8.2 (7H, m) 277 1H-NMR (CDCl3, ppm): 1.1 (6H, d), 2.2 (3H, s), 4.1 (1H, m), 5.0 (2H, s), 6.0 (1H, d), 7.0-8.4 (8H, m) 417 1H-NMR (CDCl3, ppm): 1.5 (3H, d), 2.3 (3H, s), 2.8 (3H, s), 3.2 (2H, dd), 4.7 (1H, m), 6.5 (1H, m), 7.0 (1H, s), 7.3-8.3 (6H, m) 422 1H-NMR (CDCl3, ppm): 1.47 (6H, s), 2.03 (3H, s), 2.40 (3H, s), 2.87 (2H, s), 6.03 (1H, s), 6.80 (1H, m), 7.1-8.6 (8H, m) 434 1H-NMR (CDCl3, ppm): 1.40 (6H, s), 2.03 (3H, s), 2.40 (3H, s), 2.87 (2H, s), 6.07 (1H, s), 6.77 (1H, m), 7.2-8.5 (8H, m) 521 1H-NMR (CDCl3, ppm): 1.23 (3H, d), 1.90 (3H, s), 2.26 (3H, s), 2.50-2.67 (2H, m), 4.10-4.50 (1H, m), 5.37 (2H, s), 6.15 (1H, d), 6.60 (1H, bs), 6.90-7.20 (3H, m), 7.57 (1H, bs), 7.70 (1H, d), 7.80-8.23 (3H, m) 522 1H-NMR (CDCl3, ppm): 1.50 (3H, d), 2.30 (3H, s), 2.70 (3H, s), 2.97-3.50 (2H, m), 4.56 (1H, m), 5.43 (2H, s), 6.60-8.03 (10H, m) 523 1H-NMR (CDCl3, ppm): 1.40 (6H, s), 1.98 (3H, s), 2.30 (3H, s), 2.73 (2H, s), 5.40 (2H, s), 6.03 (1H, bs), 6.60-7.20 (4H, m), 7.50-8.20 (5H, m) 529 1H-NMR (CDCl3, ppm): 1.42 (6H, s), 1.98 (3H, s), 2.30 (3H, s), 2.71 (2H, s), 5.30 (2H, s), 6.03 (1H, bs), 6.52 (1H, d), 7.03-7.35 (4H, m), 7.73 (1H, d), 7.93 (1H, d), 8.10-8.40 (2H, m) 530 1H-NMR (CDCl3, ppm): 1.63 (6H, s), 2.30 (3H, s), 2.57 (3H, s), 3.47 (2H, s), 5.30 (2H, s), 6.40 (1H, bs), 6.57 (1H, d), 7.03-8.17 (8H, m) 532 1H-NMR (CDCl3, ppm): 1.30 (4H, dd), 1.97 (3H, s), 2.28 (3H, s), 2.73-2.42 (2H, m), 4.37-4.28 (1H, m), 5.28 (2H, s), 6.42 (1H, d), 6.55 (1H, d), 7.09 (2H, t), 7.42-7.39 (2H, m), 7.51 (1H, d), 7.70 (1H, t), 8.02 (1H, d), 8.49 (1H, d) 534 1H-NMR (CDCl3, ppm): 1.24 (3H, d), 1.93 (3H, s), 2.30 (3H, s), 2.50-2.66 (2H, m), 4.23-4.40 (1H, m), 5.32 (2H, s), 6.16 (1H, d), 6.54 (1H, d), 7.06 (1H, bs), 7.11 (1H, d), 7.22 (1H, t), 7.40 (1H, d), 7.78 (1H, d), 7.97 (1H, d), 8.17 (1H, d), 8.30 (1H, bs) 536 1H-NMR (CDCl3, ppm): 1.50 (3H, d), 2.28 (3H, s), 2.73 (3H, s), 2.97-3.50 (2H, m), 4.60 (1H, m), 5.30 (2H, s), 6.53 (1H, d), 6.73 (1H, d), 7.00-8.07(8H, m) 537 1H-NMR (CDCl3, ppm): 1.40(6H, s), 1.98 (3H, s), 2.31 (3H, s), 2.81 (2H, s), 5.32 (2H, s), 6.08 (1H, bs), 6.54 (1H, d), 7.04 (1H, bs) 7.11 (1H, d), 7.20 (1H, t), 7.38 (1H, d), 7.79 (1H, d), 7.96 (1H, d), 8.22 (1H, d), 8.38 (1H, bs) 538 1H-NMR (CDCl3, ppm): 1.66(6H, s), 2.30 (3H, s), 2.60 (3H, s), 3.52 (2H, s), 5.30 (2H, s), 6.47 (1H, bs), 6.57 (1H, d), 7.03-8.23 (8H, m) 550 1H-NMR (CDCl3, ppm): 1.48 (6H, d), 2.21 (3H, s), 2.48 (3H, s), 4.13 (1H, m), 5.42 (2H, s), 6.18(1H, d), 6.91 (1H, s), 7.1-7.6 (6H, m), 8.08 (1H, d) 552 1H-NMR (CDCl3, ppm): 1.17 (3H, d), 1.89 (3H, s), 2.29 (3H, s), 2.42 (1H, dd), 2.60 (1H, dd), 3.29 (3H, s), 4.24 (1H, m), 5.42 (2H, s), 6.41 (1H, d), 6.92 (1H, s), 7.1-7.2 (2H, m). 7.6-8.2 (5H, m) 553 1H-NMR (CDCl3, ppm): 1.21 (3H, d), 1.32 (3H, t), 1.95 (3H, s), 2.29 (3H, s), 2.51 (1H, dd), 2.60 (1H, dd), 3.00 (2H, q), 4.31 (1H, m), 5.41 (2H, s), 6.28 (1H, d), 6.91 (1H, s), 7.1-7.2 (2H, m), 7.4-7.6 (3H, m), 8.09 (1H, d), 8.34 (1H, s) 554 1H-NMR (CDCl3, ppm): 1.25 (5H, dd), 1.91 (3H, s), 2.29 (3H, s), 2.60-2.54 (2H, m), 4.32-4.27 (1H, m), 5.44 (2H, s), 6.40 (1H, d), 7.06 (2H, d, J = 7.5 Hz), 7.19-7.12 (1H, m), 7.71 (1H, d), 7.94-7.91 (1H, m), 8.08 (1H, d), 8.36 (1H, s) 569 1H-NMR (CDCl3, ppm): 8.50 (1H, m), 7.95 (1H, m), 7.79-7.49 (4H, m), 7.44-7.38 (1H, m), 7.22 (1H, m), 5.75 (1H, q), 4.38 (1H, m), 2.79 (2H, m), 2.29 (3H, s), 2.20 (3H, s), 2.00 (3H, d), 1.43-1.18 (3H, d) 574 1H-NMR (CDCl3, ppm): 1.31 (3H, d), 1.95 (3H, s), 2.30 (3H, s), 2.61-2.57 (2H, m), 4.37-4.27 (1H, m), 5.79-5.73 (1H, m), 6.48 (1H, d), 7.02 (1H, s), 7.25-7.21 (2H, m), 7.52-7.36 (3H, m), 7.84-7.69 (2H, m), 8.04 (1H, d), 8.50 (1H, s) 594 1H-NMR (CDCl3, ppm): 1.22 (3H, d), 1.93 (3H, s), 2.26 (3H, s), 2.61-2.55 (2H, m), 4.36-4.27 (1H, m), 5.49 (2H, d), 6.07 (1H, d), 6.34-6.30 (1H, m), 6.98 (2H, d), 7.13 (1H, t), 7.27-7.22 (3H, m), 7.79 (1H, d), 7.97 (1H, dd), 8.08 (1H, d), 8.23 (1H, s) 595 1H-NMR (CDCl3, ppm): 1.25 (3H, d), 1.94 (3H, s), 2.27 (3H, s), 2.60-2.54 (2H, m), 4.34-4.25 (1H, m), 5.49 (2H, d), 6.42 (1H, d), 7.04-6.99 (2H, m), 7.21-7.14 (2H, m), 7.35-7.32 (1H, m), 7.72 (1H, d), 7.93 (1H, dd), 8.05 (1H, d), 8.36 (1H, s) 596 1H-NMR (CDCl3, ppm): 1.24 (3H, d), 1.97 (3H, s), 2.33 (3H, s), 2.63-2.54 (2H, m), 4.35-4.30 (1H, m), 5.52 (2H, s), 6.05 (1H, d), 7.02-7.00 (2H, m), 7.26-7.21 (1H, m), 7.35-7.32 (1H, m), 7.42-7.39 (1H, m), 7.80 (1H, t), 7.98 (1H, d), 8.18 (1H, t), 8.32 (1H, d) 626 1H-NMR (CDCl3, ppm): 1.22 (3H, d), 1.92 (3H, s), 2.30 (3H, s), 2.54 (1H, dd), 2.61 (1H, dd), 4.32 (1H, m), 5.46 (2H, s), 6.23 (1H, m), 6.94 (1H, s), 7.0-7.1 (2H, m), 7.45 (1H, m), 7.54 (1H, d), 7.72 (1H, d), 8.07 (1H, d), 8.38 (1H, bs) 632 1H-NMR (CDCl3, ppm): 1.26 (3H, dd), 1.96 (3H, s), 2.32 (3H, s), 2.61-2.55 (2H, m), 4.34-4.29 (1H, m), 5.22 (2H, s), 6.22 (1H, d), 7.21-7.13 (3H, m), 7.36 (1H, d), 7.78 (1H, d), 7.97 (1H, dd), 8.16 (1H, d), 8.35 (1H, s) 633 1H-NMR (CDCl3, ppm): 1.23 (3H, dd), 1.97 (3H, s), 2.31 (3H, s), 2.61-2.56 (2H, m), 4.37-4.32 (1H, m), 5.25 (2H, s), 6.13 (1H, d), 7.11 (2H, dd), 7.37 (1H, t), 7.48 (1H, dd), 7.61-7.53 (1H, m), 7.79 (1H, dt), 8.15 (1H, d), 8.43 (1H, d) 634 1H-NMR (CDCl3, ppm): 1.25 (4H, dd), 1.98 (3H, s), 2.33 (3H, s), 2.61-2.56 (2H, m), 8.41 (1H, s), 4.38-4.31 (1H, m), 5.24 (2H, s), 6.17 (1H, d), 7.13-7.11 (2H, m), 7.38 (1H, s), 7.46 (1H, t), 7.56 (1H, dd), 7.79 (1H, t), 8.14 (1H, d) 635 1H-NMR (CDCl3, ppm): 1.26 (3H, dd), 1.94 (3H, s), 2.31 (3H, s), 2.61-2.52 (2H, m), 4.33-4.29 (1H, m), 524 (2H, s), 6.34 (1H, d), 7.21-7.11 (3H, m), 7.39 (1H, d), 7.75 (1H, d), 7.95 (1H, dd), 8.13 (1H, d,)8.38 (1H, s) 636 1H-NMR (CDCl3, ppm): 1.25 (3H, dd), 1.93 (2H, s), 2.31 (3H, s), 2.65-2.52 (2H, m), 4.32-4.29 (1H, m), 5.26 (2H, s), 6.40 (1H, d), 7.21-7.11 (3H, m), 8.39 (1H, s), 7.42 (1H, s), 7.74 (1H, d), 7.94 (1H, d), 8.11 (1H, d) 640 1H-NMR (CDCl3, ppm): 1.29 (3H, dd), 1.95 (3H, s), 2.32 (3H, s), 2.62-2.54 (2H, m), 4.34-4.27 (1H, m), 5.31 (2H, s), 6.21 (1H, d), 7.96 (1H, d), 8.19 (1H, t), 7.21-7.13 (3H, m), 7.62 (1H, s), 7.78 (1H, d), 8.37 (1H, d) 651 1H-NMR (CDCl3, ppm): 1.24 (3H, dd), 1.96 (3H, s), 2.31 (3H, s), 2.60-2.55 (2H, m), 4.36-4.31 (1H, m), 5.31 (2H, s), 6.34 (1H, d), 7.16-7.14 (2H, m), 7.43 (1H, t), 7.53 (1H, dd), 7.64 (1H, s), 7.71 (1H, d), 8.12 (1H, d), 8.50 (1H, s) 654 1H-NMR (CDCl3, ppm): 1.26 (3H, dd), 1.93 (3H, s), 2.34 (3H, d), 2.62-2.55 (2H, m), 4.34-4.29 (1H, m), 5.31 (2H, s), 6.23 (1H, d), 7.24-7.14 (3H, m), 7.63 (1H, s), 7.78 (1H, d), 7.97 (1H, dd), 8.20 (1H, d), 8.37 (1H, s) 658 1H-NMR (CDCl3, ppm): 1.44-1.38 (3H, m), 2.35-2.30 (6H, m), 2.90-2.77 (2H, m), 4.56-4.48 (1H, m), 5.32 (2H, s), 7.18-7.14 (3H, m), 7.44-7.37 (1H, m), 7.56-7.52 (1H, m), 7.67-7.64 (2H, m), 8.10-8.07 (1H, m), 8.44-8.39 (1H, m) 660 1H-NMR (CDCl3, ppm): 1.25 (4H, dd), 1.90 (3H, s), 2.31 (3H, s), 2.63-2.55 (2H, m), 4.37-4.28 (1H, m), 5.34 (2H, s), 6.12 (1H, d), 7.22-7.15 (2H, m), 7.63 (1H, d), 7.83 (1H, t), 7.98 (1H, dt), 8.25 (1H, t), 8.34 (1H, s) 675 1H-NMR (CDCl3, ppm): 1.23 (3H, d), 1.97 (3H, s), 2.33 (3H, s), 2.63-2.54 (2H, m), 4.38-4.29 (1H, m), 5.41 (2H, s), 6.21 (1H, d), 7.09 (2H, d), 7.44 (1H, t), 7.54 (1H, d), 7.73 (1H, d), 7.84 (1H, s), 8.07 (1H, d), 8.38 (1H, s) 681 1H-NMR (CDCl3, ppm): 1.25 (3H, d), 1.95 (3H, s), 2.32 (3H, s), 2.62-2.54 (2H, m), 4.36-4.32 (1H, m), 5.52 (2H, s), 6.13 (1H, d), 7.18-7.16 (2H, m), 7.57-7.47 (2H, m), 7.76 (1H, d), 8.17 (1H, d), 8.41 (1H, s) 714 1H-NMR (CDCl3, ppm): 1.24 (3H, d), 1.99 (3H, s), 2.30 (3H, s), 2.64-2.52 (2H, m), 4.38-4.29 (1H, m), 5.49 (2H, s), 6.15 (1H, d), 7.17-7.15 (2H, m), 7.57-7.43 (2H, m), 7.75 (1H, d), 8.17 (1H, d), 8.41 (1H, s) 726 1H-NMR (CDCl3, ppm): 1.45-1.37 (3H, m), 2.32-2.30 (6H, m), 2.87-2.83 (2H, m), 4.61-4.46 (1H, m), 5.44 (2H, s), 6.90-6.88 (1H, m), 7.12-7.09 (2H, m), 7.45-7.42 (1H, m), 7.55-7.52 (1H, m), 7.68-7.66 (1H, m), 7.79-7.77 (1H, m), 8.06-8.04 (1H, m), 8.32-8.24 (1H, m) 727 1H-NMR (CDCl3, ppm): 1.44 (3H, d), 2.30 (3H, s), 2.75 (3H, s), 3.24-3.21 (2H, m), 4.62-4.53 (1H, m), 5.44 (2H, s), 6.87-6.85 (1H, m), 7.08-7.06 (2H, m), 7.42-7.32 (1H, m), 7.50-7.47 (1H, m), 7.60-7.57 (1H, m), 7.77 (1H, s), 7.91-7.87 (1H, m), 8.17-8.14 (1H, m) 729 1H-NMR (CDCl3, ppm): 1.45 (3H, d), 2.29 (3H, s), 2.75 (3H, s), 3.34-3.12 (2H, m), 4.59-4.54 (1H, m), 5.38 (2H, s), 6.86 (1H, d), 7.09-7.06 (2H, m), 7.43-7.33 (1H, m), 7.52-7.46 (1H, m), 7.59 (1H, d), 7.84 (1H, s), 7.90 (1H, d), 8.15 (1H, s) 730 1H-NMR (CDCl3, ppm): 1.23 (3H, d), 1.96 (3H, s), 2.29 (3H, s), 2.5-2.7 (2H, m), 4.31 (1H, m), 5.34 (2H, s), 6.31 (1H, d), 6.4-7.2 (5H, s), 7.4-7.8 (3H, m), 8.06 (1H, d), 8.41 (1H, bs) 741 1H-NMR (CDCl3, ppm): 1.26 (3H, d), 1.95 (3H, s), 2.18 (3H, s), 2.30 (3H, s), 2.66-2.48 (2H, m), 4.39-4.20 (1H, m), 5.31 (2H, s), 6.25 (1H, d), 7.07-7.01 (2H, m), 7.44-7.41 (2H, m), 7.55-7.51 (2H, m), 7.71 (1H, d), 8.01 (1H, d), 8.32 (1H, s) 778 1H-NMR (CDCl3, ppm): 1.31 (3H, d), 1.95 (3H, s), 2.33 (3H, t), 2.61-2.56 (2H, m), 4.40-4.29 (1H, m), 5.28 (2H, s), 6.50-6.11 (2H, m), 7.15-7.12 (2H, m), 7.45-7.42 (1H, m), 7.55-7.52 (1H, m), 7.64 (1H, s), 7.72 (1H, d), 8.12 (1H, d), 8.50 (1H, s) 799 1H-NMR (CDCl3, ppm): 1.23 (3H, d), 1.93 (3H, s), 2.32 (3H, s), 2.56 (2H, m), 4.22 (1H, m), 5.52 (2H, s), 6.55-6.02 (3H, m), 7.21 (2H, m), 7.57-7.43 (2H, m), 7.76 (1H, d), 8.15 (1H, d), 8.39 (1H, s) 1H-NMR (CDCl3, ppm): 1.24 (3H, d), 1.94 (3H, s), 2.28 (3H, s), 2.52 (1H, dd), 2.62 (1H, dd), 4.30 (1H, m), 5.38 (2H, s), 6.4-7.2 (7H, m), 7.72 (1H, d), 7.93 (1H, d), 8.06 (1H, d), 8.41 (1H, bs) 1H-NMR (CDCl3, ppm): 1.40 (6H, s), 1.93 (3H, s), 2.77 (2H, s), 5.40 (2H, s), 5.93 (1H, bs), 6.87-7.23 (4H, m), 7.63-7.95 (2H, m), 8.35-8.65 (2H, m) -
- 3-Methyl-4-nitrobenzyl chloride (1.81 g), 3,5-bis(trifluoromethyl)-1H-pyrazole (2.0 g) and potassium carbonate (1.63 g) were stirred in DMF (20 ml) at 60° C. for 1 hour. After finishing the reaction, water (100 ml) was added thereto and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous solution of sodium chloride (100 ml) and dried with anhydrous sodium sulfate. After distilling off the solvent, the obtained residue was purified by silica gel column chromatography to obtain 1-(3-methyl-4-nitrobenzyl)-3,5-bis-(trifluoromethyl)-1H-pyrazole (3.3 g).
- 1H-NMR (CDCl3, ppm): 2.59 (3H, s), 5.50 (2H, s), 6.90 (1H, s), 7.1-7.2 (2H, m), 8.00 (1H, d).
-
- To a mixture of 1-(3-methyl-4-nitrobenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole (1.4 g), ammonium acetate (30.5 g), acetone (60 ml) and water (30 ml), 20% aqueous solution of titanium trichloride (27.5 g) was added at room temperature and the mixture was stirred at room temperature for 12 hours. After finishing the reaction, the mixture was extracted with ethyl acetate, washed with saturated aqueous solution of sodium chloride and dried with anhydrous sodium sulfate. After distilling off the solvent, the obtained residue was purified by silica gel column chromatography to obtain 1-(3-methyl-aminobenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole (1.19 g).
- 1H-NMR (CDCl3, ppm): 2.14 (3H, s), 3.66 (2H, m), 5.32 (2H, s), 6.62 (1H, d), 6.89 (1H, s), 6.8-7.1 (2H, m).
-
- 1-(3-Methyl-4-nitrobenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole (17.66 g) and iron powder (13.69 g) were heated and stirred in acetic acid (150 ml) at 40° C. for 5 hours. After finishing the reaction, an insoluble matter was filtered with Celite and the filtrate was concentrated under the reduced pressure. To the residue, 1N aqueous solution of sodium hydrate (200 ml) and ethyl acetate (200 ml) were added. The organic layer was separated, washed with water, and then, dried with anhydrous magnesium sulfate. After distilling off the solvent, 1-(3-methyl-4-aminobenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole (13.0 g), which was the same as that obtained in Synthesis Example 7, was obtained.
-
- 3-Fluorophthalic anhydride (4.98 g) and 1-(3-methyl-4-aminobenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole (9.70 g) were refluxed in acetic acid (43 ml) for 3 hours. After finishing the reaction, the acetic acid was distilled off wader the reduced pressure and the obtained crude crystals were washed with t-butyl methyl ether to obtain the aimed 2-{4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-ylmethyl]-2-methylphenyl}-4-fluoroisoindol-1,3-dione (10.80 g). mp. 158-159° C.
-
- 3-Methyl-4-nitrobenzyl chloride (0.56 g), 5-(difluoromethyl)-1,2-dihydro-2-methyl-3H-1,2,4-(triazol)-3-one (0.45 g) and potassium carbonate (0.61 g) were stirred in DMF (10 ml) at 50° C. for 5 hours. After finishing the reaction, the reaction mixture was poured into ice water and extracted with ethyl acetate. The organic layer was washed with saturated aqueous solution of sodium chloride and then dried with anhydrous magnesium sulfate, and the solvent was distilled off under the reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain the aimed 5-difluoromethyl-2-methyl-4-(3-methyl-4-nitrobenzyl)-2,4-dihydro-[1,2,4]triazol-3-one (0.45 g).
- 1H-NMR (CDCl3, ppm): 2.5 (3H, s), 3.5 (3H, s), 4.9 (2H, s), 6.4 (1H, t), 72-7.3 (2H, m), 7.8-7.9 (1H, m).
-
- 3-Methyl-nitrobenzyl chloride (0.43 g), 3-heptafluoropropylsulfanyl-5-trifluoromethyl-1H-(1,2,4)-triazole (0.70 g), tetrabutylammonium iodide (0.09 g), 18-crown-6 (0.06 g) and potassium carbonate (0.48 g) were refluxed in acetonitrile (10 ml) for 2 hours. After cooling, the reaction solution was diluted with ethyl acetate and washed with water and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure and the obtained residue was purified by silica gel column chromatography to obtain 3-hepta fluoropropylsulfanyl-1-(3-methyl-4-nitrobenzyl)-5-trifluoromethyl-1H-(1,2,4)-triazole (0.30 g).
- 1H-NMR (CDCl3, ppm): 2.64 (3H, s), 5.62 (2H, s), 7.31-7.25 (2H, m), 8.05-7.86 (1H, m)
-
- To a mixture of 3-heptafluoropropylsulfanyl-1-(3-methyl-4-nitrophenyl)-5-trifluoromethyl-1H-(1,2,4)-triazole (0.3 g), ammonium acetate (4.8 g), acetone (20 ml) and water (10 ml), 20% aqueous solution of titanium trichloride (4.3 g) was added at room temperature and the mixture was stirred at room temperature for 12 hours. After finishing the reaction, the mixture was extracted with ethyl acetate, washed with saturated aqueous solution of sodium chloride and dried with anhydrous sodium sulfate. After distilling off the solvent, the obtained residue was purified by silica gel column chromatography to obtain 4-(3-heptafluoropropylsulfanyl-5-trifluoromethyl-[1,2,4]triazol-1-ylmethyl)-2-methyl-phenylamine (0.28 g)
- 1H-NMR (CDCl3, ppm): 2.17 (3H, s), 4.16 (1H, brs), 5.40 (2H, s), 6.63-6.59 (2H, m), 7.13-6.99 (1H, m).
-
- An acetonitrile solution (30 ml) of 3-trifluoromethyl-1H-pyrazole (5.0 g), dicerium ammonium nitrate (10.0 g) and iodine (5.6 g) was refluxed for 1 hour. After cooling, the reaction solution was washed with saturated aqueous solution of sodium thiosulfate and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure to obtain 4-iodo-3-trifluoromethyl-1H-pyrazole (93 g).
- 1H-NMR (CDCl3, ppm): 7.77 (1H, s).
-
- 3-Methyl-4-nitrobenzyl chloride (0.77 g), 4-iodo-3-trifluoromethyl-1H-pyrazole (0.99 g) and potassium carbonate (0.63 g) were stirred in DMF (10 ml) at 60° C. for 1 hour. After cooling, the reaction solution was diluted with ethyl acetate and washed with water and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure and the obtained residue was purified by silica gel column chromatography to obtain 4-iodo-1-(3-methyl-4-nitrobenzyl)-3-trifluoromethyl-1H-pyrazole (1.0 g).
- 1H-NMR (CDCl3, ppm): 2.62 (3H, s), 5.36 (2H, s), 7.21-7.18 (2H, m), 7.52 (1H, s), 7.98 (1H, d).
-
- 4-Iodo-1-(3-methyl-4-nitrobenzyl)-3-trifluoromethyl-1H-pyrazole (2.06 g), copper powder (0.95 g), iodopentafluoroethane (4.92 g) and DMF (13 ml) were set in an autoclave and heated and stirred for 8 hours, maintaining the inside temperature of 130-135° C. After cooling to room temperature, the reaction mixture was diluted with ethyl acetate (50 ml) and an insoluble matter was filtered with Celite and washed with ethyl acetate. The filtrate was concentrated under the reduced pressure and the obtained residue was purified by silica gel column chromatography to obtain 1-(3-methyl-4-nitrobenzyl)-4-pentafluoroethyl-3-trifluoromethyl-1H-pyrazole (1.39 g)
- 1H-NMR (CDCl3, ppm): 2.63 (3H, s), 5.38 (2H, s), 7.21-7.27 (2H, m), 7.74 (1H, s), 8.00 (1H, d).
-
- 3-Methyl-4-nitrobenzyl chloride (8.57 g), 4-iodo-3-pentafluoroethyl-1H-pyrazole (16.00 g) and potassium carbonate (7.66 g) were stirred in DMF (70 ml) at 70° C. for 1 hour. After cooling, the reaction solution was poured into water and extracted with ethyl acetate. The organic phase was washed with water and saturated aqueous solution of sodium chloride. After drying the organic layer with sodium sulfate, the solvent was distilled off under the reduced pressure and the obtained residue was purified by silica gel column chromatography to obtain 4-iodo-1-(3-methyl-4-nitrobenzyl)-3-pentafluoroethyl-1H-pyrazole (4.60 g).
- 1H-NMR (CDCl3, ppm): 2.60 (3H, s), 5.38 (2H, s), 7.22-7.15 (2H, m), 7.53 (1H, s), 7.98 (1H, d).
-
- 4-Iodo-1-(3-methyl-4-nitrobenzyl)-3-pentafluoroethyl-1H-pyrazole (1.84 g), (trifluoromethyl)trimethylsilane (1.14 g), copper(I) iodide (1.52 g), potassium fluoride (0.28 g) were stirred in DMF (8 ml) at 100° C. for 8 hours. After cooling, the mixture was poured into water and extracted with ethyl acetate. The combined organic phase was washed with saturated aqueous solution of sodium chloride. After drying the organic layer with sodium sulfate, the solvent was distilled off under the reduced pressure and the obtained residue was purified by silica gel column chromatography to obtain 1-(3-methyl-4-nitro-benzyl)-3-pentafluoroethyl-4-trifluoromethyl-1H-pyrazole (0.32 g).
- 1H-NMR (CDCl3, ppm): 2.61 (3H, s), 5.41 (2H, s), 7.31-7.18 (2H, m), 7.78 (1H, s), 8.00 (1H, d).
-
- 4-Iodo-1-(3-methyl-4-nitrobenzyl)-3-trifluoromethyl-1H-pyrazole (2.06 g), copper powder (0.95 g), heptafluoro-1-iodopropane (2.96 g) and DMF (14 ml) were set in an autoclave and heated and stirred for 8 hours, maintaining the inside temperature of 130-135° C. After cooling to room temperature, the reaction mixture was diluted with ethyl acetate (50 ml) and an insoluble matter was filtered with Celite and washed with ethyl acetate. The filtrate was concentrated under the reduced pressure and the obtained residue was purified by silica gel column chromatography to obtain 1-(3-methyl-4-nitrobenzyl)-4-pentafluoropropyl-3-trifluoromethyl-1H-pyrazole (0.80 g).
- 1H-NMR (CDCl3, ppm): 2.62 (3H, s), 5.42 (2H, s), 7.19-7.20 (2H, m), 7.74 (1H, s), 8.02 (1H, d).
-
- 4-Iodo-1-(3-methyl-4-nitrobenzyl)-3-trifluoromethyl-1H-pyrazole (2.47 g), copper powder (1.14 g), nonafluoro-1-iodobutane (4.15 g) and DMF (16 ml) were set in an autoclave and heated and stirred for 8 hours, maintaining the inside temperature of 130-135° C. After cooling to room temperature, the reaction mixture was diluted with toluene (50 ml) and an insoluble matter was filtered with Celite and washed with toluene. The filtrate was concentrated under the reduced pressure and the obtained residue was purified by silica gel column chromatography to obtain 1-(3-methyl-4-nitrobenzyl)-4-nonafluorobutyl-3-trifluoromethyl-1H-pyrazole (1.50 g).
- 1H-NMR (CDCl3, ppm): 2.62 (3H, s), 5.42 (2H, s), 7.18-7.24 (2H, m), 7.74 (1H, s), 8.00 (1H, d).
-
- An acetonitrile solution (20 ml) of 3-trifluoromethyl-1H-pyrazole (1.0 g), dicerium ammonium nitrate (2.0 g) and bromine (0.7 g) was refluxed for 2 hours. After cooling, the reaction solution was washed with saturated aqueous solution of sodium thiosulfate and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure to obtain 4-bromo-3-trifluoromethyl-1H-pyrazole (1.6 g).
- 1H-NMR (CDCl3, ppm): 7.73 (1H, s), 12.86 (1H, brs).
-
- 3-Methyl-4-nitrobenzyl chloride (0.77 g), 4-bromo-3-trifluoromethyl-1H-pyrazole (0.90 g) and potassium carbonate (0.57 g) were stirred in DMF (10 ml) at room temperature for 2 hours. The reaction solution was diluted with ethyl acetate and washed with water and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure and the obtained residue was purified by silica gel column chromatography to obtain 1-(3-methyl-4-nitrobenzyl)-4-bromo-3-trifluoromethyl-1H-pyrazole (0.9 g).
- 1H-NMR (CDCl3, ppm): 2.58 (3H, s), 5.35 (2H, s), 7.24-7.21 (2H, m), 7.49 (1H, s), 7.98 (1H, d).
-
- An acetonitrile solution (20 ml) of 3-trifluoromethyl-1H-pyrazole (0.5 g), dicerium ammonium nitrate (1.0 g) and N-chlorosuccinimide (0.7 g) was refluxed for 3 hours. After cooling, the reaction solution was washed with saturated aqueous solution of sodium thiosulfate and saturated aqueous solution of sodium chloride. After drying an organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure to obtain 4-chloro-3-trifluoromethyl-1H-pyrazole (0.9 g).
- 1H-NMR (CDCl3, ppm): 7.80 (1H, s).
-
- 3-Methyl-4-nitrobenzyl chloride (0.82 g), 4-chloro-3-trifluoromethyl-1H-pyrazole (0.63 g) and potassium carbonate (0.61 g) were stirred in DMF (10 ml) at room temperature for 2 hours. The reaction solution was diluted with ethyl acetate and washed with water and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure and the obtained residue was purified by silica gel column chromatography to obtain 1-(3-methyl-4-nitrobenzyl)-4-chloro-3-trifluoromethyl-1H-pyrazole (0.98 g).
- 1H-NMR (CDCl3, ppm): 2.62 (3H, s), 5.33 (2H, s), 7.21-7.19 (2H, m), 7.46 (1H, s), 7.98 (1H, d).
-
- 2-(Trifluoroacetyl)-1H-pyrrole (0.97 g) was added to DMF solution (10 ml) of 60% sodium hydride (0.16 g) and the mixture was stirred at room temperature for 30 mutes. 3-Methyl-4-nitrobenzyl chloride (1.0 g) was added thereto and the mixture was stirred at room temperature for 2 hours. The reaction solution was diluted with ethyl acetate and washed with water and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure and the obtained residue was purified by silica gel column chromatography to obtain 1-(3-methyl-4-nitrobenzyl)-2-(trifluoroacetyl)-1H pyrrole (1.53 g).
- 1H-NMR (CDCl3, ppm): 2.55 (3H, s), 5.59 (2H, s), 6.44-6.41 (1H, m), 6.99 (1H, d), 7.04 (1H, s), 7.22-7.19 (1H, m), 7.35-7.32 (1H, m), 7.93 (1H, d).
-
- An acetonitrile solution (20 ml) of 2-(trifluoroacetyl)-1H pyrrole (0.5 g), dicerium ammonium nitrate (0.84 g) and iodine (0.47 g) was refluxed for 2 hours. After cooling, the reaction solution was washed with saturated aqueous solution of sodium thiosulfate and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure to obtain 4-iodo-2-(trifluoroacetyl)-1H pyrrole (0.6 g).
- 1H-NMR (CDCl3, ppm): 7.28-7.35 (2H, m), 9.52 (1H, brs).
-
- 3-Methyl-4-nitrobenzyl chloride (0.63 g), 4-iodo-2-(trifluoroacetyl)pyrrole (0.89 g) and potassium carbonate (0.57 g) were stirred in DMF (10 ml) at room temperature for 2 hours. The reaction solution was diluted with ethyl acetate and washed with water and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure and the obtained residue was purified by silica gel column chromatography to obtain 4-iodo-1-(3-methyl-4-nitrobenzyl)-2-trifluoroacetyl-1H-pyrrole (0.45 g).
- 1H-NMR (CDCl3, ppm): 2.60 (3H, s), 5.56 (2H, s), 7.05-7.12 (2H, m), 7.21 (1H, d), 7.39 (1H, s), 7.94 (1H, d).
-
- 4-Iodo-1-(3-methyl-4-nitrobenzyl)-2-trifluoroacetyl-1H-pyrrole (1.75 g), copper powder (5.08 g), iodopentafluoroethane (5.92 g) and DMSO (6 ml) were set in an autoclave and heated and stirred for 8 hours, maintaining the inside temperature of 120° C. After finishing the reaction, the reaction mixture was poured into ice water and an insoluble matter was filtered with Celite, and then, it was extracted with ethyl acetate. The extracted solution was washed with water and then dried with anhydrous sodium sulfate. After distilling off the solvent, the obtained residue was purified by silica gel column chromatography to obtain 1-(3-methyl-4-nitrophenyl)-4-pentafluoroethyl-1H-pyrrole (1.35 g).
- 1H-NMR (CDCl3, ppm): 2.59 (3H, s), 5.62 (2H, s), 7.00-7.10 (2H, m), 7.43-7.50 (2H, m), 7.96 (1H, d).
- Some specific examples of other processes to synthesize the compounds of the aforementioned formula (IX) are shown below.
-
- To a toluene suspension of ethyl 4,4,4-trifluoroacetoacetate (5.0 g), sodium hydride (1.1 g) was slowly added and the mixture was stirred for 1 hour. After adding 4-chloromethyl-2-methyl-1-nitro-benzene (5.5 g) and potassium iodide dissolved in acetone (0.5 g), the reaction solution was refluxed for 5 hours. After cooling, the solvent was distilled off under reduced pressure. The residue was suspended in ethyl acetate and washed with 1N aqueous solution of hydrochloric acid. After drying the organic layer with sodium sulfate, the solvent was distilled off and the obtained residue was purified by silica gel column chromatography to obtain ethyl 4,4,4-trifluoro-2-(3-methyl-4-nitro-benzyl)-3-oxo-butyrate (6.3 g). nD 20 1.4970
-
- Ethyl 4,4,4-trifluoro-2-(3-methyl-4-nitro benzyl)-3-oxo-butyrate (2.0 g), hydrazine monohydrate (0.5 g) and a small amount of p-toluenesulfonic acid were dissolved in toluene, and the mixture was refluxed for 4 hours. After cooling, the solvent was distilled off under reduced pressure. The residue was suspended in ethyl acetate and washed with 1N aqueous solution of hydrochloric acid. After drying the organic layer with sodium sulfate, the solvent was distilled off and the obtained residue was purified by silica gel column chromatography to obtain 4-(3-methyl-4-nitro-benzyl)-5-trifluoromethyl-2,4-dihydro-pyrazol-3-one (1.0 g).
- 1H-NMR (DMSO-d6, 90 MHz): δ2.2 (3H, s), 3.8 (2H, s), 7.0 (1H, d, J=5.5 Hz), 7.2 (1H, s), 7.8 (1H, d, J=5.5 Hz), 11.2 (1H, brs).
-
- To a DMF suspension of 4-(3-methyl-4-nitro-benzyl)-5-trifluoromethyl-2,4-dihydro-pyrazol-3-one (1.0 g) and potassium carbonate (1.5 g), chlorodifluoromethane (5.7 g) was sealed in by using a balloon. After 5 hours, after the gas in the solution was saturated, the vessel was tightly closed and the mixture was stirred at 50° C. for 5 hours. After cooling, the solvent was distilled off and the obtained residue was dissolved in ethyl acetate and washed with water and saturated aqueous solution of sodium chloride. After drying the organic layer with sodium sulfate, the solvent was distilled off and the obtained residue was purified by silica gel column chromatography to obtain 5-difluoromethoxy-1-difluoromethyl-4-(3-methyl-4-nitro-benzyl)-3-trifluoromethyl-1H-pyrazole (IX-1) (0.5 g) and 3-difluoromethoxy-1-difluoromethyl-4-(3-methyl-4-nitro-benzyl)-5-trifluoromethyl-1H-pyrazole (IX-2) (0.4 g) respectively.
- (IX-1): nD 20 1.4780, (IX-2): nD 20 1.4855.
-
- (3-Methyl-4-nitrophenyl)-hydrazine (3.0 g) and hexafluoroacetylacetone (3.7 g) were dissolved in toluene and the solution was refluxed for 6 hours. After cooling, the solvent was distilled off and the obtained residue was purified by silica gel column chromatography to obtain 1-(3-methyl-4-nitrophenyl)-3,5-bis(trifluoromethyl)-1H-pyrazole (5.6 g). nD 20 1.4890.
-
- (3-Methyl-4-nitro-phenyl)-hydrazine (2.0 g) and 1,1,1,5,5,6,6,6-octafluoro-2,4-hexanedione (3.1 g) were dissolved in toluene and the solution was refluxed for 6 hours. After cooling, the solvent was distilled off and the obtained residue was purified by silica gel column chromatography to obtain 1-(3-methyl-4-nitro-phenyl)-3-pentafluoroethyl-5-trifluoromethyl-1H-pyrazole (IX-3) (3.0 g) and 2-(3-methyl-nitro-phenyl)-5-pentafluoroethyl-3-trifluoromethyl-3,4-dihydro-2H-pyrazol-3-ol (IX-4) (0.5 g), respectively.
- (IX-3): nD 20 1.4690,
- (IX-4): 1H-NMR (CDCl3, 90 MHz): δ2.6 (3H, s), 3.3 (1H, br d, J=16 Hz), 3.7 (1H, br d, J=16 Hz), 4.1 (1H, s), 7.2 (2H, m), 7.8 (1H, d, J=7.8 Hz).
-
- To a THF suspension of 1-(3-methyl-4-nitro-phenyl)-ethanone (2.0 g), sodium hydride (0.6 g) was slowly added and the mixture was stirred for 1 hour. After adding ethyl trifluoroacetate (1.6 g), the reaction mixture was refluxed for 5 hours. After cooling, the solvent was distilled off under reduced pressure. The residue was suspended in ethyl acetate and washed with 1N aqueous solution of hydrochloric acid. After drying the organic layer with sodium sulfate, the solvent was distilled off and the obtained residue was purified by silica gel column chromatography to obtain 4,4,4-trifluoro-1-(3-methyl-4-nitro-phenyl)-butane-1,3-dione (2.5 g).
- 1H NMR (CDCl3, 90 MHz): δ2.6 (3H, s), 6.5 (1H, s), 7.7-8.1 (3H, m).
-
- A toluene solution of 4,4,4-trifluoro-1-(3-methyl-4-nitro-phenyl)-butane-1,3-dione (1.8 g), 2,2,2-trifluoroethylhydrazine (1.2 g) and a catalytic amount of p-toluenesulfonic acid were refluxed for 6 hours. After cooling, the solvent was distilled off and the obtained residue was purified by silica gel column chromatography to obtain 3-(3-methyl-4-nitro-phenyl)-1-(2,2,2-trifluoro-ethyl)-5-trifluoro-methyl-1H-pyrazole (IX-5) (1.1 g) and 5-(3-methyl-4-nitro phenyl)-1-(2,2,2-trifluoro-ethyl)-3-trifluoromethyl-1H-pyrazole (IX-6) (0.5 g), respectively.
- (IX-5) mp; 98-104° C., (IX-6) mp; 50-53° C.
-
- To a dichloromethane solution of 2,2-dimethyl-1,3-dioxane-4,6-dione (10 g) and dimethylaminopyridine (17 g), a dichloromethane solution of 3-methyl-4-nitro-benzoyl chloride (14 g) was added dropwise under ice cooling. After stirring at room temperature for 3 hours and then adding 100 ml of ethanol, the mixture was refluxed for 2 hours. After cooling, the solvent was distilled off under the reduced pressure. The residue was dissolved in ethyl acetate and washed with 1N aqueous solution of hydrochloric acid. After drying the organic layer with sodium sulfate, the solvent was distilled off and the obtained residue was purified by silica gel column chromatography to obtain ethyl 3-(3-methyl-4-nitro-phenyl)-3-oxo-propionate (12.4 g). mp; 207-211° C.
-
- To an ethanol solution of ethyl 3-(3-methyl-4-nitro-phenyl)-3-oxo propionate (3.0 g), hydrazine monohydrate (0.9 g) and a small amount of p-toluenesulfonic acid were added and the mixture was refluxed for 5 hours. After cooling, the solvent was distilled off under the reduced pressure and the obtained residue was purified by silica gel column chromatography to obtain 5-(3-methyl-4-nitro-phenyl)-2,4-dihydro-pyrazol-3-one (2.6 g). mp; 218-219° C.
-
- To a DMF suspension of 5-(3-methyl-4-nitro-phenyl)-2,4-dihydro-1H-pyrazol-3-one (2.0 g) and potassium carbonate (6.3 g), chlorodifluoromethane (8.7 g) was sealed in by using a balloon. After 5 hours, after the gas in the solution was saturated, the vessel was tightly closed and the mixture was stirred at 50° C. for 5 hours. After cooling, the solvent was distilled off and the obtained residue was dissolved in ethyl acetate and washed with water and saturated aqueous solution of sodium chloride. After drying with sodium sulfate, the solvent was distilled off and the obtained residue was purified by silica gel column chromatography to obtain 5-difluoromethoxy-1-difluoromethyl-3-(3-methyl-4-nitro-phenyl)-1H-pyrazole (IX-7) (0.7 g) and 3-difluoromethoxy-1-difluoromethyl-5-(3-methyl-4-nitro-phenyl)-1H-pyrazole (IX-8) (0.5 g), respectively.
- (IX-7) rap; 80-82° C., (IX-8) mp; 99-100° C.
-
- To an ethanol solution (60 ml) of hydrazine monohydrate (5.00 g), an ethanol solution (20 ml) of 3-methyl-4-nitrobenzyl chloride (3.71 g) was added dropwise while refluxing it, and the mixture was continuously refluxed for 6 hours. After finishing the reaction, the solvent was distilled off and (3-methyl-4-nitrobenzyl)-hydrazine (3.50 g) was obtained.
- 1H-NMR (CDCl3, ppm): 2.60 (3H, s), 2.65-3.35 (3H, m), 3.95 (2H, s), 7.20-7.40 (2H, m), 7.98 (1H, d).
-
- (3-Methyl-4-nitrobenzyl)-hydrazine (1.81 g) and 5-ethoxy-1,1,1,2,2-pentafluoro-4-penten-3-one (2.18 g) were refluxed in ethanol (60 ml) for 8 hours, and p-toluenesulfonic acid (0.10 g) was added thereto and the mixture was further refluxed for 6 hours. After finishing the reaction, the solvent was distilled off and the obtained residue was purified by silica gel column chromatography (mixed solvent of n-hexane and ethyl acetate) to obtain 1-(3-methyl-4-nitrobenzyl)-5-pentafluoroethyl-1H-pyrazole (0.96 g) as the first elution portion and 1-(3-methyl-4-nitrobenzyl)-3-pentafluoroethyl-1H-pyrazole (0.50 g) as the second elution portion.
- (IX-9): 1H-NMR (CDCl3, ppm): 2.61 (3H, s), 5.49 (2H, s), 6.70 (1H, bs), 7.05-7.15 (2H, m), 7.66 (1H, bs), 7.94 (1H, d).
- (IX-10): 1H-NMR (CDCl3, ppm): 2.64 (3H, s), 5.40 (2H, s), 6.63 (1H, d), 7.07-7.20 (2H, m), 7.52 (1H, d), 7.95 (1H, d).
-
- A mixture of 5-fluoro-2-nitrotoluene (2.33 g), 4-iodo-1H-pyrazole (2.91 g) and potassium carbonate (2.49 g) was heated and stirred in DMF (30 ml) at 140° C. for 4 hours. After cooling to room temperature, the reaction mixture was poured into ice water to separate out crystals. The obtained crystals were filtered, washed with water and dried, and 4-iodo-1-(3-methyl-4-nitrophenyl)-1H-pyrazole (4.60 g) was obtained.
- 1H-NMR (CDCl3, ppm): 2.70 (3H, s), 7.50-7.70 (3H, m), 7.95-8.15 (2H, m).
-
- 4-Iodo-1-(3-methyl-4-nitrophenyl)-1H-pyrazole (1.98 g), copper powder (1.14 g), iodopentafluoroethane (8.85 g) and DMSO (9 ml) were set in an autoclave and heated and stirred for 8 hours, maintaining the inside temperature of 100° C. After finishing the reaction, the reaction mixture was poured into ice water and an insoluble matter was filtered with Celite, and then, it was extracted with ethyl acetate. The extracted solution was washed with water and dried with anhydrous sodium sulfate. After distilling off the solvent, the obtained residue was purified by silica gel column chromatography to obtain 1-(3-methyl-4-nitrophenyl)-4-pentafluoroethyl-1H-pyrazole (0.72 g).
- 1H-NMR (CDCl3, ppm): 2.70 (3H, s), 7.60-7.73 (2H, m), 7.93 (1H, s), 8.13 (1H, d), 8.23 (1H, s).
-
- To a suspension of methanol (300 ml) of 3-methyl-4-nitroacetophenone (26.88 g), sodium borohydride (8.51 g) was added at 0° C. over a period of 1 hour. The mixture was further stirred at room temperature for 8 hours. After finishing the reaction, the reaction mixture was poured into ice water (1,000 ml) and extracted with ether. The organic layer was washed with saturated aqueous solution of sodium chloride and dried with anhydrous magnesium sulfate. After distilling off the solvent, the aimed 1-(3-methyl-4-nitrophenyl)-ethanol (23.33 g) was obtained.
- 1H-NMR (CDCl3, ppm): 1.51 (3H, d), 1.98 (1H, d), 2.62 (3H, s), 4.90-5.01 (1H, m), 7.28-7.35 (2H, m), 7.98 (1H, d).
-
- Into a THF solution (35 ml) of 1-(3-methyl-4-nitrophenyl)-ethanol (5.44 g) and triethylamine (3.95 g), a THF solution (10 ml) of methanesulfonyl chloride (3.48 g) was added dropwise at 5° C. over a period of 30 minutes. Further, the mixture was stirred at room temperature for 8 hours. After finishing the reaction, the solvent was distilled off and the residue was dissolved in ethyl acetate (100 ml). It was washed with 2N aqueous solution of hydrochloric acid and saturated aqueous solution of sodium bicarbonate and then dried with anhydrous magnesium sulfate. After distilling off the solvent, the aimed 1-(3-methyl-4-nitrophenyl)-ethyl methanesulfonate (5.80 g) was obtained.
- 1H-NMR (CDCl3, ppm): 1.74 (3H, d), 2.65 (3H, s), 2.95 (3H, s), 5.76 (1H, q), 7.35-7.45 (2H, m), 8.01 (1H, d).
-
- 1-(3-Methyl-4-nitrophenyl)-ethyl methanesulfonate (2.59 g), 3-trifluoromethyl-1H-pyrazole (1.09 g), potassium carbonate (1.66 g) and 18-crown-6 (0.26 g) were refluxed in acetonitrile (100 ml) for 6 hours. After finishing the reaction, water (100 ml) was added to the mixture and extracted with ethyl acetate. The organic layer was washed with saturated aqueous solution of sodium bicarbonate and then dried with anhydrous sodium sulfate. After distilling off the solvent, the obtained residue was purified by silica gel column chromatography to obtain 1-[1-(3-methyl-4-nitrophenyl)-ethyl]-3-trifluoromethyl-1H-pyrazole (1.60 g).
- 1H-NMR (CDCl3, ppm): 1.95 (3H, d), 2.59 (3H, s), 5.59 (1H, q), 6.57 (1H, bs), 7.13-7.20 (2H, m), 7.47 (1H, bs), 8.00 (1H, d).
-
- Ethyl pentafluoropropylenate (14.6 g) and hydrazine monohydrate (3.6 g) were refluxed in tetrahydrofuran (300 ml) for 1 hour. After cooling to room temperature, trifluoroacetamidine (10.0 g) was added dropwise to the mixture and it was refluxed for 3 hours. After finishing the reaction, saturated aqueous solution of sodium hydrogen carbonate was added thereto and the mixture was extracted with ethyl acetate. After drying the organic layer with anhydrous magnesium sulfate, the solvent was distilled off to obtain crude 3-pentafluoroethyl-5-trifluoromethyl-1H-(1,2,4)-triazole (7.9 g).
-
- 1-(3-Methyl-4-nitrophenyl)-ethyl methanesulfonate (2.5 g), 3-pentafluoroethyl-5-trifluoromethyl-1H-(1,2,4)-triazole (2.2 g), potassium carbonate (1.6 g) and 18-crown-6 (0.26 g) were refluxed in acetonitrile (100 mil) for 6 hours. After finishing the reaction, water (100 ml) was added thereto and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous solution of sodium chloride (100 ml) and then dried with anhydrous sodium sulfate. After distilling off the solvent, the obtained residue was purified by silica gel column chromatography (mixed solvent of n-hexane and ethyl acetate) to obtain (IX-11) 1-([1-(3-methyl-4-nitro phenyl)-ethyl]-5-pentafluoroethyl-3-trifluoromethyl-1H-(1,2,4)-triazole (0.95 g) as the first elution portion and (IX-12) 1-([1-(3-methyl-4-nitro-phenyl)-ethyl]-3-pentafluoroethyl-5-trifluoromethyl-1H-(1,2,4)-triazole (1.35 g) as the second elution portion.
- (IX-11)
- 1H-NMR (CDCl3) δ: 8.03-7.97 (1H, m), 7.37 (2H, t, J=5.4 Hz), 5.86 (1H, q, J=7.0 Hz), 2.62 (3H, s), 2.00 (3H, d, J=7.0 Hz).
- (IX-12)
- 1H-NMR (CDCl3) δ: 7.98 (1H, d; J=8.2 Hz), 7.34 (2H, t, J=7.1 Hz), 5.81 (1H, q, J=7.0 Hz), 2.63 (3H, s), 2.01 (3H, d, J=7.0 Hz).
-
- Sodium hydride (0.10 g) was added to a DMF solution (12 ml) of 4-methyl-5-pentafluoroethyl-4H-[1,2,4]triazol-3-thiol (0.70 g), and the mixture was stirred at room temperature until the generation of hydrogen gas stopped. Continuously, 5-fluoro-2-nitrotoluene (0.47 g) was added thereto and the mixture was further stirred at room temperature for 1 hour. After cooling to room temperature, the reaction mixture was poured into ice water and extracted with ethyl acetate. The organic layer was washed with saturated aqueous solution of sodium chloride and then dried with anhydrous sodium sulfate. After distilling off the solvent, the obtained residue was purified by silica gel column chromatography (mixed solvent of n-hexane and ethyl acetate) to obtain the aimed 4-methyl-3-(3-methyl-4-nitrophenyl sulfanyl)-5-pentafluoroethyl-4H-(1,2,4)-triazole (0.55 g).
- 1H-NMR (CDCl3, ppm): 2.70 (3H, s), 3.80 (3H, s), 8.10-8.30 (3H, m).
-
- A mixture of 2-methylmelcapto-4.6-bistrifluoromethyl-pyrimidine (36 g), oxone (126 g), water (500 ml) and chloroform (110 ml) was refluxed for 2 days. After cooling to room temperature, the mixture was extracted with dichloromethane. The obtained organic layer was washed with water and then dried with anhydrous sodium sulfate. After distilling off the solvent, the obtained crude crystals were washed with petroleum ether to obtain 2-methanesulfonyl-4.6-bistrifluoromethyl-pyrimidine (7.5 g).
- 1H-NMR (CDCl3, ppm): 3.48 (3H, s), 8.19 (1H, s).
-
- 4-Nitro-m-cresol (0.77 g), 2-methanesulfonyl-4,6-bistrifluoromethyl-pyrimidine (1.77 g) and potassium carbonate (1.04 g) were refluxed in acetonitrile (15 ml) for 5 hours. After finishing the reaction, the reaction mixture was poured into ice to separate out crystals. The obtained crystals were filtered and dried to obtain 2-(3-methyl-4-nitrophenoxy)-4,6-bistrifluoromethyl-pyrimidine (1.03 g).
- 1H-NMR (CDCl3, ppm): 2.60 (3H, s), 7.1-7.3 (2H, m), 7.67 (1H, s), 8.10 (1H, d).
-
- (3-Methyl-4-nitrophenyl)-acetonitrile (3.52 g) was dissolved in pyridine (30 ml), thereto excess H2S was bubbled into at room temperature for 3 hours. Then the mixture was poured onto ice. The precipitate was collected by suction, washed with water and dried to obtain 2-(3-methyl-4-nitro-phenyl)-thioacetamide (1.69 g).
- 1H-NMR (CDCl3, ppm): 2.60 (3H, s), 4.06 (2H, s), 6.40-8.00 (5H, m)
-
- 2-(3-Methyl-4-nitrophenyl)-thioacetamide (1.00 g), 1-bromo-3,3,4,4,4-pentafluoro-2-butanone (1.15 g) and potassium carbonate (0.79 g) were stirred in DMF (10 ml) at room temperature for 1 hour. The reaction solution was diluted with ethyl acetate and washed with water and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure and the obtained residue was purified by silica gel column chromatography to obtain 2-(3-Methyl-4-nitro-phenyl)-thioacetimidic acid 3,3,4,4,4-pentafluoro-2-oxo-butyl ester (1.30 g).
- 1H-NMR (CDCl3, ppm): 2.55 (3H, s), 3.57 (2H, dd), 3.90 (2H, d), 7.24-7.22 (2H, m), 7.91-7.89 (1H, m)
-
- Trifluoroacetic anhydride (1.47 g) was added to 2-(3-Methyl-4-nitro-phenyl)-thioacetimidic acid 3,3,4,4,4-pentafluoro ester (130 g) and triethylamine (0.71 g) in dichloromethane (10 ml), and stirred at room temperature for 20 minutes. The reaction solution was washed with water, and the solvent was distilled off under the reduced pressure and the obtained residue was purified by silica gel column chromatography to obtain 2-(3-methyl-4-nitro-benzyl)-4-perfluoroethyl-thiazole (0.70 g).
- 1H-NMR (CDCl3, ppm): 2.63 (3H, s), 4.43 (2H, s), 7.30-7.28 (2H, m), 7.75 (1H, s), 7.98 (1H, d)
-
- An acetonitrile solution (20 ml) of 3-pentafluoroethyl-1H-pyrazole (2.0 g), dicerium ammonium nitrate (3.0 g) and iodine (1.6 g) was refluxed for 3 hours. After cooling, the reaction solution was washed with saturated aqueous solution of sodium thiosulfate and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure to obtain 4-iodo-3-pentafluoroethyl-1H-pyrazole (32 g).
- 1H-NMR (CDCl3, ppm): 7.77 (1H, s), 11.11 (1H, m)
-
- 4-Iodo-3-pentafluoroethyl-1H-pyrazole (6.24 g), copper powder (3.81 g), Iodo-1,1,2,2-tetrafluoroethane (9.12 g) and DMF (30 ml) were set in an autoclave and heated and stirred for 8 hours, maintaining the inside temperature of 120-125° C. After cooling to room temperature, the insoluble material was filtered off through Celite and washed with diethyl ether. The filtrate was diluted with water and extracted with diethyl ether. The organic phase was washed with water and dried over sodium sulfate, and concentrated under the reduced pressure. The crude product was distilled under reduced pressure to obtain 3-pentafluoroethyl-4-(1,1,2,2-tetrafluoroethyl)-1H-pyrazole (0.60 g), bp. 125-135° C./20 mbar.
- 1H-NMR (CDCl3, ppm): 5.98 (1H, tt), 7.96 (1H, s), 12.22 (1H, m)
-
- 4-Iodo-3-pentafluoroethyl-1H-pyrazole (12.48 g), copper powder (7.63 g), iodopentafluoroethane (29.50 g) and DMF (60 ml) were set in an autoclave and heated and stirred for 8 hours, maintaining the inside temperature of 120-125° C. After cooling to room temperature, the insoluble material was filtered off through Celite and washed with diethyl ether. The filtrate was diluted with water and extracted with diethyl ether. The organic phase was washed with water and dried over sodium sulfate, and concentrated under the reduced pressure. The crude product was distilled under reduced pressure to obtain 3,4-bis-pentafluoroethyl-1H-pyrazole (1.20 g), bp. 110-115° C./20 mbar.
- 1H-NMR (CDCl3, ppm): 7.99 (1H, s), 12.31 (1H, m).
-
- An acetonitrile solution (20 ml) of 4-methyl-1H-pyrazole (0.5 g), dicerium ammonium nitrate (1.7 g) and iodine (1.9 g) was refluxed for 3 hours. After cooling, the reaction solution was washed with saturated aqueous solution of sodium thiosulfate and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure to obtain 3,5-diiodo-4-methyl-1H-pyrazole (1.2 g).
- 1H-NMR (CDCl3, ppm): 2.03 (3H, s), 6.96 (1H, br s)
-
- 5-Trifluoromethyl-1H-(1,2,4)-triazole-3-thiol (1.0 g), heptafluoro-1-iodopropane (3.5 g) and triethylamine (0.90 g) were stirred in DMF (10 ml) at 90° C. for 24 hours. After cooling to room temperature; the reaction mixture was diluted with ethyl acetate and washed with water and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure to obtain 3-heptafluoropropylsulfanyl-5-trifluoromethyl-1H-(1,2,4)-triazole (0.70 g).
-
-
Solvent: Dimethylformamide: 3 parts by weight Emulsifier: Polyoxyethylene alkyl phenyl ether: 1 part by weight - In order to make an appropriate formulation of an active compound, 1 part by weight of the active compound was mixed with the above-mentioned amount of solvent containing the above-mentioned amount of emulsifier and the mixture was diluted with water to a prescribed concentration.
- Leaves of sweet potato were soaked in the test solution diluted to a prescribed concentration with water, dried in the air and put in a dish of 9 cm diameter.
- 10 larvae of Spodoptera litura at the third instar were placed on the leaves and kept in a room at the constant temperature of 25° C. After 2 and 4 days further leaves of sweet potato were added and after 7 days the number of dead larvae was counted and the rate of death was calculated.
- In this test the results of 2 dishes at 1 section were averaged.
- Paddy rice (variety: Tamanishiki) planted in a pot was treated by spraying 50 ml per pot of the diluted aqueous solution of the prescribed concentration of the active compound prepared in the same manner as in the above-mentioned Biological Test Example 1. After the treated rice plant was dried in the air, their foliage part was cut in 4-5 cm length, which were put in a dish with 9 cm diameter with a sheet of filter paper and 2 ml of water. Five larvae of Cnaphalocrocis medinalis Guenee at the second instar were put in the dish that was placed in a room at the constant temperature of 25° C. After 2 and 4 days; each rest (each ⅓ amount) of foliage parts of rice plant were cut in the same manner and added to the dish. After 7 days the number of dead larvae was counted and the rate of death was calculated. In this test the results of 2 dishes at 1 section were averaged.
- In the above Biological Test Examples 1 and 2, as specific examples, the compounds of the aforementioned compound Nos. 8, 9, 10, 11, 12, 13, 14, 15, 16, 45, 47, 48, 49, 51, 52, 53, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 93, 103, 107, 116, 128, 132, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 153, 155, 157, 174, 176, 177, 178, 180, 181, 182, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 226, 227, 229, 230, 231, 238, 239, 242, 243, 251, 253, 262, 264, 268, 270, 281, 299, 308, 310, 318, 322, 413, 414, 417, 422, 434, 446, 448, 473, 475, 492, 506, 508, 512, 518, 520, 539, 543, 544, 545, 546, 547, 548, 549, 552, 554, 559, 561, 562, 563, 564, 565, 566, 567, 568, 570, 571, 572, 573, 574, 578, 579, 580, 626, 637, 638, 639, 640, 641, 642, 643, 644, 645, 646, 647, 648, 649, 650, 655, 656, 657, 658, 659, 660, 661, 662, 663, 664, 665, 666, 667, 668, 669, 670, 671, 672, 681, 761, 762, 763, 804 and 920 showed controlling effect of 100% of rate of death at 20 ppm concentration of the active component.
- About 30 bred Myzus persicae resistant to organophosphorous agents and carbamates were inoculated per 1 seedling of eggplant planted in a vinyl pot of 6 cm diameter. One day after the inoculation, a sufficient amount of a diluted aqueous solution of a prescribed concentration of an active compound prepared as mentioned above, was sprayed by using a spray gun. After spraying it was placed in a green house of 28° C. and the rate of death was calculated 7 days after the spraying. Test was repeated twice.
- The compounds of the aforementioned compound Nos. 140, 141, 144, 146, 147, 148, 174, 176, 177, 178, 180, 181, 211, 213, 214, 215, 218, 220, 222, 226, 239, 243, 569, 570, 572, 579, 761, 797 and 920 offered to the test as specific examples showed controlling effect of 100% of rate of death at 100 ppm concentration of the effective component.
- To a mixture of 10 parts of the compound of the present invention (No. 8), 30 parts of bentonite (montmorillonite), 58 parts of talc and 2 parts of ligninsulfonate salt, 25 parts of water are added, well kneaded, made into granules of 10-40 mesh by an extrusion granulator and dried at 40-50° C. to obtain granules.
- 95 Parts of clay mineral particles having particle diameter distribution in the range of 0.2-2 mm are put in a rotary mixer. While rotating it, 5 parts of the compound of the present invention (No. 11) are sprayed together with a liquid diluent, wetted uniformly and dried at 40-50° C. to obtain granules.
- 30 Parts of the compound of the present invention (No. 12), 55 parts of xylene, 8 parts of polyoxyethylene alkyl phenyl ether and 7 parts of calcium alkylbenzenesulfonate are mixed and stirred to obtain an emulsifiable concentrate.
- 15 Parts of the compound of the present invention (No. 15), 80 parts of a mixture of white carbon (hydrous amorphous silicon oxide fine powders) and powder clay (1:5), 2 parts of sodium alkylbenzenesulfonate and 3 parts of sodium alkylnaphthalenesulfonate-formalin-condensate are crushed and mixed to make a wettable powder.
- 20 Parts of the compound of the present invention (No. 16), 30 parts of sodium ligninsulfonate, 15 parts of bentonite and 35 parts of calcined diatomaceous earth powder are well mixed, added with water, extruded with 0.3 mm screen and dried to obtain water dispersible granules.
Claims (6)
1-3. (canceled)
4. A process for the preparation of a compound of formula (I),
wherein
X represents hydrogen, halogen, nitro, C1-6alkylsulfonyloxy, C1-6alkylsulfinyl, C1-6alkylsulfenyl or C1-6alkylsulfonyl,
R1 represents C1-6alkyl, C1-6alkylthio-C1-6alkyl, C1-6alkylsulfinyl-C1-6alkyl or C1-6alkylsulfonyl-C1-6alkyl,
Y represents halogen or C1-6alkyl,
m represents 0 or 1,
A represents O, S, SO, SO2, CH2 or CH(CH3), and
Q represents a 5-membered or 6-membered heterocyclic group that contains at least one hetero atom selected from the group consisting of N, O and S and can be optionally substituted;
comprising
(a) reacting a compound of formula (II)
wherein Y, A, m and Q have the same definition as above, in the presence of an inert solvent, and optionally in the presence of an acid catalyst, or
(b) reacting a compound of formula (IV)
wherein X, Y, A, m and Q have the same definitions as above with a compound of formula (V)
H2N—R1 (V)
H2N—R1 (V)
wherein R1 has the same definition as above, in the presence of an inert solvent, and optionally in the presence of an acid catalyst, or
(c) reacting a compound of formula (VI)
wherein Y, A, m and Q have the same definition as above, in the presence of an inert solvent, and optionally in the presence of an acid catalyst, or
(d) reacting a compound of formula (VII)
wherein X, Y, A, m and Q have the same definitions as above, with a compound of formula (V),
H2N—R1 (V)
H2N—R1 (V)
wherein R1 has the same definitions as above, in the presence of an inert solvent, and optionally in the presence of an acid catalyst, or
(e) reacting a compound of formula (VIII)
wherein X, Y, A, m and Q have the same definitions as above, with a compound of formula (V),
H2N—R1 (V)
H2N—R1 (V)
wherein R1 has the same definitions as above, in the presence of an inert solvent, and optionally in the presence of an acid catalyst, or
(f) in case where R1 represents C1-6alkylsulfinyl-C1-6alkyl or C1-6alkylsulfonyl-C1-6alkyl in formula (I): reacting a compound of formula (If)
5-9. (canceled)
10. A compound of formula (VII)
wherein
X represents hydrogen, halogen, nitro, C1-6alkylsulfonyloxy, C1-6alkylsulfinyl, C1-6alkylsulfenyl or C1-6alkylsulfonyl,
Y represents halogen or C1-6alkyl,
A represents O, S, SO, SO2, CH2 or CH(CH3),
m represents 0 or 1, and
Q represents a 5-membered or 6-membered heterocyclic group that contains at least one hetero atom selected from the group consisting of N, O and S and can be optionally substituted.
11. (canceled)
12. A compound of formula (IX)
wherein
X represents hydrogen, halogen, nitro, C1-6alkylsulfonyloxy, C1-6alkylsulfinyl, C1-6alkylsulfenyl or C1-6alkylsulfonyl,
Y represents halogen or C1-6alkyl,
A represents O, S, SO, SO2, CH2 or CH(CH3),
m represents 0 or 1, and
Q represents a 5-membered or 6-membered heterocyclic group that contains at least one hetero atom selected from the group consisting of N, O and S and can be optionally substituted.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/694,441 US20100130743A1 (en) | 2004-03-12 | 2010-01-27 | Heterocycle-substituted, n-phenyl-phthalamide derivatives, related compounds and their use as insecticides |
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004070976 | 2004-03-12 | ||
JP2004-70976 | 2004-03-12 | ||
JP2004-235553 | 2004-08-12 | ||
JP2004235553 | 2004-08-12 | ||
JP2004367994A JP2006076990A (en) | 2004-03-12 | 2004-12-20 | Insecticidal benzenedicarboxamide compounds |
JP2004-367994 | 2004-12-20 | ||
PCT/EP2005/002130 WO2005095351A1 (en) | 2004-03-12 | 2005-03-01 | N1 - ((pyrazol-1-ymethyl) -2-methylphenyl)- phatalamide derivatives and related compounds insecticides |
US59236107A | 2007-05-24 | 2007-05-24 | |
US12/694,441 US20100130743A1 (en) | 2004-03-12 | 2010-01-27 | Heterocycle-substituted, n-phenyl-phthalamide derivatives, related compounds and their use as insecticides |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2005/002130 Division WO2005095351A1 (en) | 2004-03-12 | 2005-03-01 | N1 - ((pyrazol-1-ymethyl) -2-methylphenyl)- phatalamide derivatives and related compounds insecticides |
US59236107A Division | 2004-03-12 | 2007-05-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
US20100130743A1 true US20100130743A1 (en) | 2010-05-27 |
Family
ID=34963925
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/592,361 Expired - Fee Related US7674807B2 (en) | 2004-03-12 | 2005-03-01 | Heterocycle-substituted n-phenyl-phthalamide derivatives, related compounds and their use as insecticides |
US12/694,441 Abandoned US20100130743A1 (en) | 2004-03-12 | 2010-01-27 | Heterocycle-substituted, n-phenyl-phthalamide derivatives, related compounds and their use as insecticides |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/592,361 Expired - Fee Related US7674807B2 (en) | 2004-03-12 | 2005-03-01 | Heterocycle-substituted n-phenyl-phthalamide derivatives, related compounds and their use as insecticides |
Country Status (12)
Country | Link |
---|---|
US (2) | US7674807B2 (en) |
EP (1) | EP1727804B1 (en) |
JP (2) | JP2006076990A (en) |
KR (1) | KR101166122B1 (en) |
AR (1) | AR048086A1 (en) |
AT (1) | ATE447556T1 (en) |
AU (1) | AU2005229339B2 (en) |
BR (1) | BRPI0508632A (en) |
DE (1) | DE602005017474D1 (en) |
ES (1) | ES2334508T3 (en) |
TW (1) | TWI350143B (en) |
WO (1) | WO2005095351A1 (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090209769A1 (en) * | 2005-03-02 | 2009-08-20 | Bayer Cropscience Ag | Alkyl-Analide Producing Method |
US8669341B2 (en) | 2011-08-29 | 2014-03-11 | Ticona Llc | Solid-state polymerization of a liquid crystalline polymer |
US8778221B2 (en) | 2011-08-29 | 2014-07-15 | Ticona Llc | Aromatic amide compound |
WO2014149779A1 (en) | 2013-03-15 | 2014-09-25 | Life Technologies Corporation | Chemical device with thin conductive element |
US8852730B2 (en) | 2011-08-29 | 2014-10-07 | Ticona Llc | Melt-extruded substrate for use in thermoformed articles |
US8906258B2 (en) | 2011-08-29 | 2014-12-09 | Ticona Llc | Heat-resistant liquid crystalline polymer composition having a low melting temperature |
US9045685B2 (en) | 2011-08-29 | 2015-06-02 | Ticona Llc | Cast molded parts formed from a liquid crystalline polymer |
US9051514B2 (en) | 2011-08-29 | 2015-06-09 | Ticona Llc | High flow liquid crystalline polymer composition |
US9057016B2 (en) | 2011-08-29 | 2015-06-16 | Ticona Llc | Melt polymerization of low melt viscosity liquid crystalline polymers |
US9074133B2 (en) | 2011-08-29 | 2015-07-07 | Ticona Llc | Thermotropic liquid crystalline polymer with improved low shear viscosity |
US9096794B2 (en) | 2011-08-29 | 2015-08-04 | Ticona Llc | High flow liquid crystalline polymer composition |
US9102792B2 (en) | 2013-02-22 | 2015-08-11 | Ticona Llc | High performance polymer composition with improved flow properties |
US9206300B2 (en) | 2013-06-07 | 2015-12-08 | Ticona Llc | High strength thermotropic liquid crystalline polymer |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004055582A1 (en) * | 2004-11-18 | 2006-05-24 | Bayer Cropscience Ag | N-heterocyclic-phthalic |
JP2006347936A (en) * | 2005-06-15 | 2006-12-28 | Bayer Cropscience Ag | Insecticidal benzanilides |
JP2007031395A (en) * | 2005-07-29 | 2007-02-08 | Bayer Cropscience Ag | Insecticidal 3-acylaminobenzanilide |
DE102006032168A1 (en) * | 2006-06-13 | 2007-12-20 | Bayer Cropscience Ag | Anthranilic acid diamide derivatives with heteroaromatic substituents |
JP2010030970A (en) * | 2008-07-31 | 2010-02-12 | Bayer Cropscience Ag | Insecticidal benzenedicarboxamide derivative |
EP2184273A1 (en) | 2008-11-05 | 2010-05-12 | Bayer CropScience AG | Halogen substituted compounds as pesticides |
EP2253617A1 (en) | 2009-05-20 | 2010-11-24 | Bayer CropScience AG | Halogenated compounds as pesticides |
US8377970B2 (en) * | 2009-10-08 | 2013-02-19 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel |
US8993612B2 (en) | 2009-10-08 | 2015-03-31 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer |
WO2012004208A1 (en) * | 2010-07-09 | 2012-01-12 | Bayer Cropscience Ag | Anthranilic acid diamide derivative as a pesticide |
CN102613183A (en) * | 2012-03-07 | 2012-08-01 | 中化蓝天集团有限公司 | Insecticide |
BR102013021210B1 (en) | 2013-01-25 | 2015-12-01 | Fundação Universidade Fed De São Carlos | process of obtaining biopolymeric nanoparticles containing oil and azadirachta extracts indicates a. juss (neem), biopolymer nanoparticles and powder microparticles |
CN104397008A (en) * | 2014-10-25 | 2015-03-11 | 北京燕化永乐生物科技股份有限公司 | Insecticidal composition |
CN109485588A (en) * | 2018-12-25 | 2019-03-19 | 成都蓝蜻蜓生物技术有限公司 | A kind of synthetic method of fipronil bisamide |
Citations (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2785115A (en) * | 1955-04-04 | 1957-03-12 | Smidth & Co As F L | Rotary kiln with integral cooler |
US3264177A (en) * | 1964-02-17 | 1966-08-02 | Dow Chemical Co | Methods for the control of arachnids |
US3309266A (en) * | 1965-07-01 | 1967-03-14 | Chevron Res | Insecticidal compositions containing oalkyl-s-alkyl phosphoroamidothioates and methods for killing insects therewith |
US4053608A (en) * | 1974-08-14 | 1977-10-11 | Sankyo Company Limited | Compositions and methods for the treatment of coccidiosis |
US4181800A (en) * | 1975-10-06 | 1980-01-01 | Fujisawa Pharmaceutical Co., Ltd. | 2-Azetidinone compounds and processes for preparation thereof |
US4808430A (en) * | 1987-02-27 | 1989-02-28 | Yazaki Corporation | Method of applying gel coating to plant seeds |
US5416103A (en) * | 1992-09-21 | 1995-05-16 | Basf Aktiengesellschaft | N-cyclohex(en)yl-pyridine carboxamides and compositions containing them for controlling fungal pests |
US5438070A (en) * | 1992-09-21 | 1995-08-01 | Basf Aktiengesellschaft | Carboxanilides, their preparation and compositions containing them for controlling harmful fungi |
US5556988A (en) * | 1991-11-22 | 1996-09-17 | Basf Aktiengesellschaft | Anilide derivatives and their use for combating botrytis |
US5876739A (en) * | 1996-06-13 | 1999-03-02 | Novartis Ag | Insecticidal seed coating |
US20010004181A1 (en) * | 1999-12-17 | 2001-06-21 | Peter Jaenker | Piezoelectric actuator system |
US20010041814A1 (en) * | 1997-11-25 | 2001-11-15 | Masanori Tohnishi | Phthalic acid diamide derivatives fluorine-containing aniline compounds as starting material, agricultural and horticultural insecticides, and a method for application of the insecticides |
US20030119670A1 (en) * | 1999-12-08 | 2003-06-26 | Tomohiro Araki | Difluoromethyltriazolone compounds, use of the same and intermediates for the production thereof |
US6603044B1 (en) * | 1998-11-30 | 2003-08-05 | Nihon Nohyaku Co., Ltd. | Phthalamide derivatives, or salt thereof agrohorticultural insecticide, and method for using the same |
US20030176428A1 (en) * | 1998-11-16 | 2003-09-18 | Schneidersmann Ferdinand Martin | Pesticidal composition for seed treatment |
US6639109B1 (en) * | 1999-09-28 | 2003-10-28 | Nihon Nohyaku Co., Ltd. | Process for production of thioalkylamine derivatives |
US6642379B1 (en) * | 1999-06-25 | 2003-11-04 | Nihon Nohyaku Co., Ltd. | Benzamide derivatives, insecticides for agricultural and horticultural use and usage thereof |
US6747041B1 (en) * | 1999-06-24 | 2004-06-08 | Nihon Nohyaku Co., Ltd. | Heterocyclic dicarboxylic acid diamide derivatives, agricultural/horticultural insecticides and method of using the same |
US6864289B1 (en) * | 1999-09-24 | 2005-03-08 | Nihon Nohyaku Co., Ltd. | Aromatic diamide derivatives or salts thereof, agricultural/horticultural chemicals and method of using the same |
US20090023752A1 (en) * | 2004-11-18 | 2009-01-22 | Bayer Cropscience Ag | N-Heterocyclylphthaldiamides as Insecticides |
US20090209769A1 (en) * | 2005-03-02 | 2009-08-20 | Bayer Cropscience Ag | Alkyl-Analide Producing Method |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL33143A (en) * | 1968-10-16 | 1973-04-30 | Pfizer | Substituted as-triazine-3,5(2h,4h)-diones,their preparation and use against coccidiosis |
FI762480A (en) | 1975-09-15 | 1977-03-16 | Du Pont | |
JPS54138570A (en) * | 1978-01-03 | 1979-10-27 | Ici Ltd | 11benzyll1*2*3*66tetrahydropyridine derivative*its manufacture and therapeutical or preventive drug containing said derivative for thrombosis and thromboangitis obliterans |
DE3305569A1 (en) | 1983-02-18 | 1984-08-23 | Bayer Ag, 5090 Leverkusen | BISCARBOXAMIDES FOR THE FIGHT AGAINST DISEASES AND METHOD FOR THE PRODUCTION THEREOF |
JPH0678308B2 (en) | 1985-04-24 | 1994-10-05 | 三共株式会社 | Phthalimide derivative and agricultural / horticultural germicide containing the same |
CA1300137C (en) | 1985-12-27 | 1992-05-05 | Hiroshi Hamaguchi | Pyrazole oxime derivative and its production and use |
US4897484A (en) * | 1986-12-19 | 1990-01-30 | Ciba-Geigy Corporation | Process for the preparation of substituted pyridines |
US5010098A (en) | 1987-07-29 | 1991-04-23 | American Cyanamid Company | Arylpyrrole insecticidal acaricidal and nematicidal agents and methods for the preparation thereof |
US4892578A (en) * | 1987-11-06 | 1990-01-09 | Fmc Corporation | Phenylmethyl-4,4-dimethyl-3-isoxazolidinone plant regulators |
RO112860B1 (en) | 1991-11-22 | 1998-01-30 | Uniroyal Chem Co Inc | Phenylhydrazine derivatives, pesticide and method for pest control |
US5223526A (en) | 1991-12-06 | 1993-06-29 | Monsanto Company | Pyrazole carboxanilide fungicides and use |
US5683966A (en) * | 1993-08-11 | 1997-11-04 | Fmc Corporation | Herbicidal 3-(substituted-benzyl)-1-methyl-6-trifluoromethyluracils |
GB9510459D0 (en) | 1995-05-24 | 1995-07-19 | Zeneca Ltd | Bicyclic amines |
US5914344A (en) | 1996-08-15 | 1999-06-22 | Mitsui Chemicals, Inc. | Substituted carboxanilide derivative and plant disease control agent comprising same as active ingredient |
GB9624611D0 (en) | 1996-11-26 | 1997-01-15 | Zeneca Ltd | Bicyclic amine compounds |
TW515786B (en) * | 1997-11-25 | 2003-01-01 | Nihon Nohyaku Co Ltd | Phthalic acid diamide derivatives, agricultural and horticultural insecticides, and a method for application of the insecticides |
JP3358024B2 (en) * | 1998-11-30 | 2002-12-16 | 日本農薬株式会社 | Phthalamide derivatives or salts thereof, agricultural and horticultural insecticides, and methods of using the same |
JP4706810B2 (en) | 1999-06-24 | 2011-06-22 | 日本農薬株式会社 | Pyridine ring dicarboxylic acid diamide derivatives, agricultural and horticultural insecticides and methods of use thereof |
JP4798410B2 (en) | 1999-06-25 | 2011-10-19 | 日本農薬株式会社 | Benzamide derivatives, agricultural and horticultural insecticides and methods of use thereof |
AR030154A1 (en) | 1999-07-05 | 2003-08-13 | Nihon Nohyaku Co Ltd | DERIVED FROM FTALAMIDE, DERIVED FROM HETEROCICLIC AMINE USEFUL AS INTERMEDIARY FOR THE PRODUCTION OF THE SAME, AGROHORTICALLY INSECTICIDE AND METHOD TO USE SUCH INSECTICIDE |
JP4993049B2 (en) * | 1999-09-24 | 2012-08-08 | 日本農薬株式会社 | Aromatic diamide derivatives or salts thereof, agricultural and horticultural agents and methods of use thereof |
US20020134012A1 (en) | 2001-03-21 | 2002-09-26 | Monsanto Technology, L.L.C. | Method of controlling the release of agricultural active ingredients from treated plant seeds |
JP2003012638A (en) * | 2001-04-26 | 2003-01-15 | Nippon Nohyaku Co Ltd | Phthalamide derivative and insecticide for agriculture and horticulture and method for using the same |
CN1505612A (en) | 2001-04-26 | 2004-06-16 | �ձ��ݶ�ũҩ��ʽ���� | Phthalamide derivative and insecticide for agriculture and horticulture and method for using the same |
JP2003040864A (en) | 2001-05-21 | 2003-02-13 | Nissan Chem Ind Ltd | Phthalic acid diamide compound and pest-controlling agent |
DE10136065A1 (en) | 2001-07-25 | 2003-02-13 | Bayer Cropscience Ag | pyrazolylcarboxanilides |
AU2002323743A1 (en) | 2001-08-01 | 2003-02-17 | Nissan Chemical Industries, Ltd. | Substituted amides and pest controllers |
JP2005035964A (en) * | 2002-08-26 | 2005-02-10 | Nissan Chem Ind Ltd | Substituted benzanilide compound and vermin controlling agent |
EP1538138A4 (en) | 2002-08-26 | 2007-07-25 | Nissan Chemical Ind Ltd | Substituted benzanilide compound and pest control agent |
DE10250743A1 (en) * | 2002-10-31 | 2004-05-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New amide compounds having MCH antagonist activity and medicaments containing these compounds |
DE10303589A1 (en) | 2003-01-29 | 2004-08-12 | Bayer Cropscience Ag | pyrazolylcarboxanilides |
JP2004277333A (en) | 2003-03-14 | 2004-10-07 | Bayer Cropscience Ag | Insecticidal phthalamide derivative |
DE102005022147A1 (en) | 2005-04-28 | 2006-11-02 | Bayer Cropscience Ag | Active agent combination, useful to e.g. combat animal parasites and phytopathogenic fungus, comprises a carboxyamide compound and/or at least an active agent e.g. acetylcholine-receptor-agonist/antagonist |
-
2004
- 2004-12-20 JP JP2004367994A patent/JP2006076990A/en active Pending
-
2005
- 2005-03-01 JP JP2007502233A patent/JP5336074B2/en not_active Expired - Fee Related
- 2005-03-01 ES ES05731064T patent/ES2334508T3/en active Active
- 2005-03-01 BR BRPI0508632-9A patent/BRPI0508632A/en active Search and Examination
- 2005-03-01 DE DE602005017474T patent/DE602005017474D1/en active Active
- 2005-03-01 AU AU2005229339A patent/AU2005229339B2/en not_active Ceased
- 2005-03-01 WO PCT/EP2005/002130 patent/WO2005095351A1/en active Application Filing
- 2005-03-01 AT AT05731064T patent/ATE447556T1/en not_active IP Right Cessation
- 2005-03-01 EP EP05731064A patent/EP1727804B1/en not_active Not-in-force
- 2005-03-01 KR KR1020067021031A patent/KR101166122B1/en not_active IP Right Cessation
- 2005-03-01 US US10/592,361 patent/US7674807B2/en not_active Expired - Fee Related
- 2005-03-08 AR ARP050100889A patent/AR048086A1/en not_active Application Discontinuation
- 2005-03-11 TW TW094107388A patent/TWI350143B/en not_active IP Right Cessation
-
2010
- 2010-01-27 US US12/694,441 patent/US20100130743A1/en not_active Abandoned
Patent Citations (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2785115A (en) * | 1955-04-04 | 1957-03-12 | Smidth & Co As F L | Rotary kiln with integral cooler |
US3264177A (en) * | 1964-02-17 | 1966-08-02 | Dow Chemical Co | Methods for the control of arachnids |
US3309266A (en) * | 1965-07-01 | 1967-03-14 | Chevron Res | Insecticidal compositions containing oalkyl-s-alkyl phosphoroamidothioates and methods for killing insects therewith |
US4053608A (en) * | 1974-08-14 | 1977-10-11 | Sankyo Company Limited | Compositions and methods for the treatment of coccidiosis |
US4181800A (en) * | 1975-10-06 | 1980-01-01 | Fujisawa Pharmaceutical Co., Ltd. | 2-Azetidinone compounds and processes for preparation thereof |
US4808430A (en) * | 1987-02-27 | 1989-02-28 | Yazaki Corporation | Method of applying gel coating to plant seeds |
US5556988A (en) * | 1991-11-22 | 1996-09-17 | Basf Aktiengesellschaft | Anilide derivatives and their use for combating botrytis |
US5416103A (en) * | 1992-09-21 | 1995-05-16 | Basf Aktiengesellschaft | N-cyclohex(en)yl-pyridine carboxamides and compositions containing them for controlling fungal pests |
US5438070A (en) * | 1992-09-21 | 1995-08-01 | Basf Aktiengesellschaft | Carboxanilides, their preparation and compositions containing them for controlling harmful fungi |
US5876739A (en) * | 1996-06-13 | 1999-03-02 | Novartis Ag | Insecticidal seed coating |
US20010041814A1 (en) * | 1997-11-25 | 2001-11-15 | Masanori Tohnishi | Phthalic acid diamide derivatives fluorine-containing aniline compounds as starting material, agricultural and horticultural insecticides, and a method for application of the insecticides |
US6362369B2 (en) * | 1997-11-25 | 2002-03-26 | Nihon Nohyaku Co., Ltd. | Phthalic acid diamide derivatives fluorine-containing aniline compounds as starting material, agricultural and horticultural insecticides, and a method for application of the insecticides |
US6559341B2 (en) * | 1997-11-25 | 2003-05-06 | Nihon Nohyaku Co., Ltd. | Phthalic acid diamide derivatives, fluorine-containing aniline compounds as starting material, agricultural and horticultural insecticides, and a method for application of the insecticides |
US20030176428A1 (en) * | 1998-11-16 | 2003-09-18 | Schneidersmann Ferdinand Martin | Pesticidal composition for seed treatment |
US6603044B1 (en) * | 1998-11-30 | 2003-08-05 | Nihon Nohyaku Co., Ltd. | Phthalamide derivatives, or salt thereof agrohorticultural insecticide, and method for using the same |
US6747041B1 (en) * | 1999-06-24 | 2004-06-08 | Nihon Nohyaku Co., Ltd. | Heterocyclic dicarboxylic acid diamide derivatives, agricultural/horticultural insecticides and method of using the same |
US6642379B1 (en) * | 1999-06-25 | 2003-11-04 | Nihon Nohyaku Co., Ltd. | Benzamide derivatives, insecticides for agricultural and horticultural use and usage thereof |
US6864289B1 (en) * | 1999-09-24 | 2005-03-08 | Nihon Nohyaku Co., Ltd. | Aromatic diamide derivatives or salts thereof, agricultural/horticultural chemicals and method of using the same |
US6639109B1 (en) * | 1999-09-28 | 2003-10-28 | Nihon Nohyaku Co., Ltd. | Process for production of thioalkylamine derivatives |
US20030119670A1 (en) * | 1999-12-08 | 2003-06-26 | Tomohiro Araki | Difluoromethyltriazolone compounds, use of the same and intermediates for the production thereof |
US20010004181A1 (en) * | 1999-12-17 | 2001-06-21 | Peter Jaenker | Piezoelectric actuator system |
US20090023752A1 (en) * | 2004-11-18 | 2009-01-22 | Bayer Cropscience Ag | N-Heterocyclylphthaldiamides as Insecticides |
US20090209769A1 (en) * | 2005-03-02 | 2009-08-20 | Bayer Cropscience Ag | Alkyl-Analide Producing Method |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090209769A1 (en) * | 2005-03-02 | 2009-08-20 | Bayer Cropscience Ag | Alkyl-Analide Producing Method |
US8053572B2 (en) | 2005-03-02 | 2011-11-08 | Bayer Cropscience Ag | Alkyl-analide producing method |
US8906258B2 (en) | 2011-08-29 | 2014-12-09 | Ticona Llc | Heat-resistant liquid crystalline polymer composition having a low melting temperature |
US8778221B2 (en) | 2011-08-29 | 2014-07-15 | Ticona Llc | Aromatic amide compound |
US8852730B2 (en) | 2011-08-29 | 2014-10-07 | Ticona Llc | Melt-extruded substrate for use in thermoformed articles |
US8669341B2 (en) | 2011-08-29 | 2014-03-11 | Ticona Llc | Solid-state polymerization of a liquid crystalline polymer |
US9005475B2 (en) | 2011-08-29 | 2015-04-14 | Ticona Llc | Aromatic amide compound |
US9045685B2 (en) | 2011-08-29 | 2015-06-02 | Ticona Llc | Cast molded parts formed from a liquid crystalline polymer |
US9051514B2 (en) | 2011-08-29 | 2015-06-09 | Ticona Llc | High flow liquid crystalline polymer composition |
US9057016B2 (en) | 2011-08-29 | 2015-06-16 | Ticona Llc | Melt polymerization of low melt viscosity liquid crystalline polymers |
US9074133B2 (en) | 2011-08-29 | 2015-07-07 | Ticona Llc | Thermotropic liquid crystalline polymer with improved low shear viscosity |
US9096794B2 (en) | 2011-08-29 | 2015-08-04 | Ticona Llc | High flow liquid crystalline polymer composition |
US9102792B2 (en) | 2013-02-22 | 2015-08-11 | Ticona Llc | High performance polymer composition with improved flow properties |
WO2014149779A1 (en) | 2013-03-15 | 2014-09-25 | Life Technologies Corporation | Chemical device with thin conductive element |
US9206300B2 (en) | 2013-06-07 | 2015-12-08 | Ticona Llc | High strength thermotropic liquid crystalline polymer |
Also Published As
Publication number | Publication date |
---|---|
US20070299085A1 (en) | 2007-12-27 |
JP5336074B2 (en) | 2013-11-06 |
ES2334508T3 (en) | 2010-03-11 |
JP2007528881A (en) | 2007-10-18 |
AU2005229339A1 (en) | 2005-10-13 |
WO2005095351A1 (en) | 2005-10-13 |
EP1727804B1 (en) | 2009-11-04 |
AU2005229339B2 (en) | 2010-11-11 |
KR20070026449A (en) | 2007-03-08 |
BRPI0508632A (en) | 2007-08-14 |
KR101166122B1 (en) | 2012-07-27 |
ATE447556T1 (en) | 2009-11-15 |
US7674807B2 (en) | 2010-03-09 |
TW200601970A (en) | 2006-01-16 |
DE602005017474D1 (en) | 2009-12-17 |
EP1727804A1 (en) | 2006-12-06 |
TWI350143B (en) | 2011-10-11 |
JP2006076990A (en) | 2006-03-23 |
AR048086A1 (en) | 2006-03-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7674807B2 (en) | Heterocycle-substituted n-phenyl-phthalamide derivatives, related compounds and their use as insecticides | |
JP5069107B2 (en) | Use of sulfonanilide as an agricultural and horticultural fungicide | |
US8431600B2 (en) | Carboxamides | |
US7842710B2 (en) | Carboxamides | |
WO2015016372A1 (en) | Tetrazolinone compound, and use therefor | |
US20090105316A1 (en) | Biphenyl Thiazole Carboxamides | |
DE102005009458A1 (en) | pyrazolylcarboxanilides | |
US20080242708A1 (en) | Biphenyl-Thiazolo-Carboxamides | |
US11155517B2 (en) | 4-substituted phenylamine derivatives and their use to protect crops by fighting undesired phytopathogenic micoorganisms | |
EP1727816B1 (en) | Microbicidal silylated carboxamides | |
JP2007515444A (en) | Substituted heterocyclic amides with bactericidal effects | |
WO2005077952A1 (en) | Imidazolopyrimidines used as fungicidal active ingredients | |
MXPA06010270A (en) | N1 - ((pyrazol-1-ymethyl) -2-methylphenyl)- phatalamide derivatives and related compounds insecticides | |
JP2007516249A (en) | 7-amino-5-halopyrazolopyrimidines having fungicidal action | |
CN1930129A (en) | N1 - ((pyrazol-1-ymethyl) -2-methylphenyl)- phatalamide derivatives and related compounds insecticides | |
JP2007513908A (en) | Pyrazolopyrimidines as bactericidal active ingredients | |
US20070293514A1 (en) | Triazolopyrimidines | |
JP2007516246A (en) | Pyrazolopyrimidines | |
MX2008007856A (en) | Biphenyl carboxamides for controlling micro-organisms |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |