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Publication numberUS2157503 A
Publication typeGrant
Publication dateMay 9, 1939
Filing dateApr 10, 1936
Priority dateApr 10, 1936
Publication numberUS 2157503 A, US 2157503A, US-A-2157503, US2157503 A, US2157503A
InventorsArthur E Smith
Original AssigneeArthur E Smith
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Ampoule syringe
US 2157503 A
Abstract  available in
Previous page
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Claims  available in
Description  (OCR text may contain errors)


Filed April 10, 1936 2 Sheets-Sheet l A. E. SMITH AMPOULE SYRINGE May 9, l939.

Filed April lO, 1956 2 SheetS-Shee 2 INVENTOR. ARTHUR E. SM/TH.

ATTORN Patented May 9, 1939 UNITED STATES AMPOULE SYRINGE Arthur E. Smith,

Application April 10,

2 Claims.

This invention relates to syringes.

The general object of the invention is to provide an improved syringe which is particularly adapted for use in connection with ampoules.

A further object of the invention is to provide an improved ampoule for use in a syringe.

An additional object of the invention is to provide a syringe and ampoule wherein novel means is provided for preventing leakage at the front end of the ampoule.

Another object of the invention is to provide a novel cork for use in an ampoule.

Another object of the invention is to provide novel means for sealing an ampoule.

Other objects and the advantages of the invention will be apparent from the following description taken in connection with the accompanying drawings, wherein:

Fig. 1 is a central, sectional View through a 20 syringe and ampoule embodying the features of my invention;

Fig. 2 is an enlarged, fragmentary, central, sectional, View through the upper end of my improved ampoule showing the cork therein;

Fig, 3 is an enlarged, fragmentary, central, sectional view showing the upper end of the ampoule with the cork engaged by the plunger;

Fig. 4 is a view similar to Fig. 1 showing a slight modication of my invention;

Fig. 5 is an enlarged, fragmentary, sectional view showing the front end of the modified syringe;

Fig. 6 is a view similar to Fig. 1 showing a further modii'lcatiom and Fig. 7 is an enlarged, fragmentary, sectional View showing the lower end of the syringe shown in Fig. 6.

Referring to the drawings by reference characters I have shown my invention as embodied in a syringe which is indicated generally at I0. As shown the syringe includes a barrel I I having a front member I2 threaded therein. This front member is provided with a threaded front end on which a needle I3 is mounted. The front member is also provided with a closure piercing member or needle I4 which is fixed thereon and which is provided at its inner end I5 with a sharpened portion which projects into a recess in the front member. The outer end of the front member recess is shown as cylindrical as at I6, while the inner portion is rounded as at I1.

Opposite the front member the barrel is provided with a closure I8 which is threaded as at I9 to the barrel and slidably mounted within the closure is a plunger rod 20 having a head 2I on Los Angeles, Calif.

1936, Serial No. 73,654

(Cl. 12S-218) the lower end thereof. Surrounding the plunger rod and fitted within the closure I8 are a plurality of segmental members 22 which are in telescopic engagement with the lower member having an ampoule engaging head 23 thereon. 'Ihis head includes a skirt 24 which receives the head 2I on the plunger. The plunger rod 20 is surrounded by a spring 25 which engages the head 23 and tends to urge the head away from the closure.

Mounted Within the barrel I show a removable ampoule 26 which is preferably made of glass and which is cylindrical in form with the upper end of the ampoule engaged by the skirt 24 on the head 23 of the plunger. The front end of the ampoule is of reduced diameter as at 2'I and on the reduced portion I mount a seal 28 comprising an inner cap which is preferably made of rubber. This cap includes a skirt 29 which tightly engages the end of the ampoule and the skirt is provided with an end portion 30 which is shown as slightly thicker than the skirt and which includes a boss which extends into the ampoule. Over the skirt I place a cap or covering of thin, exible, transparent material such as Celluloid, collodion, regenerated cellulose such as Cellophane, or other material preferably of a nature so that it shrinks when it dries and thus tightly engages the rubber closure and causes this closure to tightly engage the neck of the ampoule. The covering is shown as extending down onto the neck as at 3| and thus a tight seal is secured.

This seal, it will be noted, consists of two separate media both of which are impervious but are capable of being penetrated by the sharpened end I5 of the needle with the outer member tough and more resistant so that it will in a measure serve as a protection for the rubber member.

The rear end of the ampoule is provided with a cork 35 which includes a protuberant head portion 36 and a side wall 31. Within the side Wall 37 and preferably spaced therefrom is an internal boss 38 which terminates short of the end of the side wall. 'Ihe slide wall is provided on its inner surface with a peripheral groove 39 in which a sealing disk 43 which may be made of Celluloid is seated. This disk 40 serves to hold a medicinal preparation shown as a tablet 4I in place in the cork. The tablet 4I is shown as contacting the lower face of the boss 38 and the disk 40.

In use pressure is applied to the head portion 36 of the cork thus pushing the boss 38 inwardly so that the tablet 4I causes the disk l0 to be unseated. The closure I8 is then removed and the ampoule is placed in the barrel of the syringe and the closure is replaced. The spring 25 acting through the skirt 24 pushes the ampoule forwardly so that the needle point I5 pierces the seal 28. The seal 28 engages the rounded portion I'I on the front member on the syringe.

The interior of the ampoule is filled with a suitable vehicle for the medicinal preparation 4I and thus when the steps mentioned have occurred the preparation 4I is discharged into the vehicle in the ampoule and a fresh solution of material is provided. To make an injection the plunger 20 is forced inwardly thus causing the cork 36 to move within the ampoule and causing the material to pass out through the needle I3. The pressure of the spring 25, together with this forward thrust of the plunger causes the seal 28 at its lower edge to tightly engage the curved Wall of the end member and thus hold the parts in a leak preventing position. The needle I5 forces the boss on the end member 30 outwardly so that leakage is prevented, also the engagement between the rounded portion I'I of the front member and the seal tends to force the seal against the needle to prevent leakage.

In Figs. 4 and 5 I have indicated a slight modication of my invention generally at 50. In this modification the closure member, barrel, and plunger are similar to those previously described and similar parts have been indicated by similarly primed reference characters.

The front member of the modification indicated at 5I is provided with a reduced portion 52 having an aperture 53 which at its lower end includes a rounded seat 54. A needle 55 has a ball-like member 56 engaging the seat 54 while a cap 51 which is threaded to the front member 5I includes a seat 58 which engages the ball member 56 to hold the parts assembled. The needle includes an injection point 59 and an ampoule piercing point 6U. The ampoule shown in Fig. 4 is similar to the ampoule previously described but the front member 5I instead of being provided with a rounded recess to receive the ampoule has a plane end wall 6I and may be provided with a sharpened protuberance 62 surrounding the aperture 53.

In use the ampoule is inserted in the barrel and the closure I8 is replaced. The head 23 then urges the ampoule forward in the barrel. The plunger is then operated causing the head 2I to engage the head portion 36 of the cork and thus pushing the portion inwardly and discharging the medicinal contents into the ampoule. The needle 55 is then inserted so that the point 6I] thereof passes through the seal on the ampoule whereupon the cap 5l' is secured in place.

In Fig. 6 I have shown a further modification of my invention wherein a barrel 65 is provided with a threaded end closure 66 which includes a tapered recess 61 engaging an ampoule 68. 'Ihe threads on the closure 66 are preferably triple threads and they are suiciently long so that the closure will engage ampoules of various lengths. The ampoule 68 is of a uniform diameter throughout and is provided with a seal 69 which includes an inner layer of rubber and an outer layer which is of tough, flexible, material, previously described, such as Celluloid. The rubber seal l0 includes a circumferential bead 'I2 and a peripheral bead 'I2' which engage the plane end face 'I3 of a front member 'I4 which is provided with a central bore I5. The beads 'I2 and 'I2' are within and without the end of the ampoule thus when pressure is applied these tend to force the seal so that it has a tendency to wrap around the end of the ampoule.

The front member 'I4 is preferably secured to the barrel by spinning the front portion of the barrel 'I6 into a recess 'I'I in the front member.

In use of the syringe shown in Figs. 6 and '7 an ampoule is inserted in the barrel and the closure is tightened and the ampoule is pushed forward so that the protuberances 'I2 and I2 of the seal engage the plane face 'I3 of the front member. A needle 'I9 may then be inserted in the bore 'I5 and forced through the seal with a ball on the needle engaging a recess 8| of the front member after which a cap 82 is screwed onto the front member.

A plunger 83 passes through the closure 66 and has a head B4 thereon which engages a cork 35 similar to the cork previously described so that when the plunger is operated the preparation is rst discharged. After this preparation has been distributed throughout the uid in the ampule the injection is made.

From the foregoing description it will be apparent that I have invented a novel syringe and ampoule which can be economically manufactured and which is highly efficient in use.

Having thus described my invention I claim:

l. A cork for use in an ampoule, said cork including a body having a protuberance at one end, said body having a boss on the face opposite said protuberance and having a skirt surrounding said boss, a disk engaging the inner wall of said skirt and a medicinal preparation in said cork between said disk and said boss.

2. An ampoule having a cylindrical wall and having a cork therein, said cork being made of rubber including a body having a protuberance at the outer end, said body having a boss on the face opposite said protuberance and having a skirt spaced from said boss, said skirt having a circumferentialrecess on the inner wall thereof, a disk seated in said recess and a medicinal preparation engaging said disk.


Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US2608972 *May 16, 1949Sep 2, 1952Chrigstrom Knut VilhelmGuide for hypodermic syringes
US2629379 *Feb 21, 1951Feb 24, 1953Abbott LabPuncture indicating closure for multiple dose vials
US3080866 *Jul 7, 1961Mar 12, 1963Friedman BenjaminHypodermic needle
US3092108 *Apr 9, 1954Jun 4, 1963Friedman BenjaminSyringes and/or hypodermic needles, and cartridges therefor
US3618603 *Jan 29, 1969Nov 9, 1971Levenson M FSyringe
US3838690 *Aug 16, 1973Oct 1, 1974B FriedmanReplaceable cartridge hypodermic syringe having sterile maintenance of needle
US4966585 *May 31, 1988Oct 30, 1990Gangemi Ronald JInfusion apparatus
US5336200 *Mar 10, 1992Aug 9, 1994Injectimed, Inc.Retractable sleeve-protection for injection apparatus employing carpules
US6354603Feb 7, 1999Mar 12, 2002Alain VilletteSealing device for carpule
US9375385 *Dec 20, 2013Jun 28, 2016Becton Dickinson FrancePre-filled active vial having integral plunger assembly
US20140114274 *Dec 20, 2013Apr 24, 2014Becton Dickinson France S.A.S."Pre-Filled Active Vial Having Integral Plunger Assembly"
DE102015002234A1 *Feb 19, 2015Jun 9, 2016Elm - Plastic GmbhInjektor zur Abgabe eines flüssigen oder pastösen Stoffs, insbesondere Medikaments
WO2000001430A2Jul 2, 1999Jan 13, 2000Alain VilletteSealing device for capsule, in particular for injection capsules or cartridges
WO2000001430A3 *Jul 2, 1999Aug 10, 2000Alain VilletteSealing device for capsule, in particular for injection capsules or cartridges
WO2011045386A2 *Oct 14, 2010Apr 21, 2011Sanofi-Aventis Deutschland GmbhArrangement for use in a drug delivery device
WO2011045386A3 *Oct 14, 2010Jun 30, 2011Sanofi-Aventis Deutschland GmbhArrangement for use in a drug delivery device
U.S. Classification604/89, 604/229
International ClassificationA61M5/24, A61M5/34, A61J1/06
Cooperative ClassificationA61M2005/2437, A61J1/062, A61M5/344, A61M2005/247, A61M5/24, A61M2005/2407, A61M2005/2477
European ClassificationA61M5/24, A61J1/06B