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Publication numberUS2159217 A
Publication typeGrant
Publication dateMay 23, 1939
Filing dateNov 5, 1937
Priority dateNov 5, 1937
Publication numberUS 2159217 A, US 2159217A, US-A-2159217, US2159217 A, US2159217A
InventorsClayton H Frost, Lozier Matthew
Original AssigneeCook Lab Inc
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Controllable transfer element for multiple ampules
US 2159217 A
Abstract  available in
Previous page
Next page
Claims  available in
Description  (OCR text may contain errors)

May 23, 1939. M LOZIER ET AL 2,159,217


3 Claims.

This invention relates to a multiple compartment ampule and to improved means designedfor use with said ampule for transferring and expelling the contents from the ampule.

An object of this invention is to provide a container having separate compartments containing dissimilar ingredients, the said compartments being defined by three spaced disks of pierceable material, the two outer disks being slidably positioned in the container while the intermediate disk remains in one fixed position.

Another object of this invention is to provide a hypodermic syringe and a piercing element having a through channel designed to provide communication between the compartments in the said ampule when the piercing element is pushed through two adjacent disks and the said element having means to prevent the escape of the mixed fluids through the outer end of said channel during transferrence.

In our prior disclosure it was necessary to move the intermediate disk during the operation of the expulsion of the mixed liquids into the patients tissue and to facilitate the movement of all the disks, it was necessary to lubricate the outer peripheries of the disks.

This lubrication together with the ever present possibility of expansion and contraction of the glass container due to variation in temperature as well as to the slight variations in the internal diameter of the container, presented a possibility of seepage around the intermediate disk from one compartment to the other which is detrimental to the use of the invention since the main object of the invention is to maintain the two dissimilar liquids in hermetic separation until the moment of intermixture of the liquids by the aid of a transfer element.

To prevent the possibility of seepage we have provided a new method of expulsion of the liquid contents of the ampule which does not require the movement of the intermediate disk and it is therefore not necessary to lubricate the outer periphery of said disk, whereby said disk remains practically immovable.

For the expulsion of the mixture from the ampule we have provided an improved controllable transfer element which allows the passage of the mixture from the ampule directly to and through a hypodermic needle into the tissue.

With the above and other objects in view, the invention will be hereinafter more particularly described in connection with the accompanying drawings and pointed out in the claims which form part of this specification.

Reference will now be had to the drawings, wherein like numerals of reference designate corresponding parts throughout the several views, in which:

Figure 1 is a central longitudinal cross-sectional view of our multiple compartment ampule havingthree disks in predetermined spaced relation therein, and being designed for surgical or dental use, in conjunction with a transfer element having a piercing needle designed for the purpose, the ampule being shown on an enlarged scale.

Figure 2 is a cross-sectional view of the ampule after the liquid in one compartment has been transferred into the other compartment, and shows the piercing needle inserted through two adjoining disks in the ampule.

Figure 3 is a plan view of a standard hypodermic syringe in use with our multiple compartment ampule, showing the three disks in position when the liquid in the ampule has been partly discharged.

Figure 4 is an enlarged fragmentary view of the transfer element shown in Figures 1 and 2.

Figure 5 is a longitudinal cross-sectional view of an improved transfer element mounted on a hypodermic syringe which allows the passage of the two combined liquids from the ampule through a valve mechanism and directly through a hypodermic needle into the tissue.

In the illustrated embodiment of the invention the numeral llJ indicates a cross-sectiona l'view of our double compartment ampule, comprising an elongated tubular outer member or casing llpreferably made of glass and having three disks l2, I2 and I2 inserted therein. The disks are preferably made of a yieldable material such as rubber, and are of sufficiently large external diameter to frictionally engage the internal diameter of the casing II in sealing relation.

Figure 1 shows the ampule I with the disks positioned therein in spaced relation so as to form the compartments l3, M which may contain dissimilar liquids. The compartments l3 and H are hermetically sealed from each other by the disk I2 due to its frictional sealing engagement in the tubular member II. It will be noted that in Figure 1 the disk I2 is positioned at or near one end l of the tubular member II, and that the disk I2 is spaced at a predetermined distance therefrom to form the compartment l3, while the disk It has been positioned inwardly from the end l6 of the tubular member ll so as to form the closed compartment I4. This position of the disk 12 between the end l6 and stopper I2 is governed by the length of the compartment I3.

The length of the open end space is substantially the same as the length of the compartment, l3.

The end space is essential to permit the movement of the disk I2 when the liquid in the compartment [3 is transferred into the compartment I4.

For the purpose of our invention, all the disks are positioned entirely inside the casing l I. I The end disks I2 and I2 have their outer peripheries Figure 4 shows an enlarged fragmentary portlon of a transfer element II which may be employed for transferring the liquid in the compartment I3 into the compartment I4. The transfer element I1 comprises a casing I8 having secured thereto a collar I9 the outer diameter of which is smaller than the inner diameter of the casing II of the ampule Ill. The collar I9 has a. piercing needle 26 secured therein. The needle has a sharp and tapering end portion 2I and an axially positioned channel 22 adapted to communicate with a lateral inlet 23 in the side of the piercing needle.

' Figure 2 shows a cross-sectional view of an ampule I placed inside the transfer element I1 and shows the piercing needle 20 inserted in the disks I2 and I2 and the disk I2 moved inwardly of the casing II and the disk I2 moved to the end I6.

Due to the sharpness of the piercing needle 20 and the frictional resistance of the disks I2, I2 and I 2 in the casing II, it is possible to pierce the disks I2 and I2 by exerting manual pressure against the end of the transfer element II without altering the position of said disks.

When the compartments I3 and I4 contain liquids, due to the incompressibility of the liquids, when further pressure is exerted against the transfer element II it will cause the disk I2 to be moved into contacting relation with the disk I2 and the disk I2 to move simultaneously and equally to the end I6 of the ampule I6, since the channel 22 in the piercing needle 20 connects the compartments l3 and I4 and permits transfer of the liquid from the compartment I3 into the compartment I4. It is also to be noted that both end disks I2 and I2 are movable simultaneously and equally while the intermediate disk I2 remains fixed during said liquid transferrence.

For the expulsion of the two combined liquids from the ampule III, we may utilize an ordinary hypodermic syringe 21 in which the ampule I0 is placed with the disks I2 and I2 facing the inner end 29 of the hypodermic needle 30, as

shown in Figure 3. The ampule I 0 with the disks I2 and I2 in contacting relation is placed in the syringe 21 with the end 29 of the needle 30 penetrating through both of said disks and entering into the compartment I4. The plunger 28 of the hypodermic syringe 21 has been moved into the body of the syringe. The disk I2 is shown part way inside the ampule I0 and the liquid in the ampule has been partly discharged. Further movement of the plunger 28 will cause the complete discharge of the combined liquids from the compartment I4.

Figure shows an enlarged cross-sectional view of a hypodermic syringe 35 having our improved controllable transfer, element 36 which makes it possible to combine dissimilar liquids as well as to expel the combined liquid from the ampule I6 directly through a hypodermic needle 31 into the tissue without removing the ampule from the syringe.

'Iheitransfer element 36 comprises a metal body 38 having a valve 39 'slidably mounted therein. The valve 39 is held against a seat 40 by a coil spring\4l positioned between a projection on the valve stem and an annular shoulder adjoining the valve seat. The valve 39 has a stem 42 which extends into a centrally positioned aperture in the plug 43 where it is in alinement with the inner end of .the hypodermic needle 31. The

inner end of the needle extends through a sleeve 44 and is in slightly spaced relation from the end of the stem 42. The sleeve 44 is tightly driven in an aperture in the plug 43 with one end projecting outwardly from said plug to form a tight joint with a soft metal collar 45 secured to the hypodermic needle when said needle is pressed tightly against said sleeve. A housing 46 is in threaded engagement with a threaded end portion of the plug 43.

As shown, the inner end of the, hypodermic needle is in slightly spaced relation from the end of the valve-stem 42 when the valve 39 is in seating relation with the seat 40.

The housing 46, in the disclosure shown, must be partly unscrewed by the user before transfer, thereby seating the valve 39 on its seat 40 and preventing the escape of the liquid through the hypodermic needle 31.

It is thus possible, by slightly rotating the housing 46 in one direction to move the hypodermic needle 31 inwardly of the syringe 35 and cause unseating of the valve 39 from the seat 40 and permit outflow of the contents of the ampule I0 through a hollow piercing needle 41 in the inner end of the body 38 and entirely through the transfer element 36 and the hypodermic needle 31. The soft metal collar 45 serves to prevent leakage through the housing 46.

It is to be noted that while we have shown a controllable transfer element 36 having a disk valve and seat, that we may utilize an ordinary ball-and-spring valve in which the ball may be unseated by the end of the hypodermic needle 31.

By using an intermediate disk I 2 having a slightly larger diameter than the inner diameter of the casing II and by pressing same to its permanent position in the ampule we are enabled to secure a permanently sealed joint in which the,

disk has a tendency to adhere to the glass in permanent intimate union thereby preventing the moving of said disk I2 and securing against leakage between the two compartments.

It is also to be noted that the piercing needle 4'I shown in Figure 5 is constructed with an axially positioned channel and a lateral inlet similar to the piercing needle 20, best shown in Figure 4. The axially positioned channel of the needle 41 extends entirely through said needle from end to end.

From theabove description it will be seen that we have provided a transfer element I! having a tubular casing I8 serving to centralize the ampule I0 therein during transfer. The length of the collar I 9 is made equal to the length of the compartment I3 so as to expel the entire contents from said compartment. Also that by the use of the transfer element II we are enabled to utilize an ordinary syringe for expelling the contents of the ampule I0 into the tissue through the hypodermic needle 36. Also that we have provided a controllable transfer element 36 mounted on a hypodermic syringe 35 by the use of which it is possible to expel the combined contents of the ampule HI directly through a hypodermic needle into the tissue without removing the ampule from the instrument. The controllable transfer element 36 may be easily removed from the syringe 35 for sterilization or replacement.

The syringe 35 has a plunger 48 having an elongated axial aperture 49 which permits the inner end of the piercing needle 41 to enter therein when the plunger is in its maximum stroke inwardly.

Our improvements are applicable for the easy and instantaneous alkalinization of local anaesthetic solutions which are ordinarily unstable. This allows for nascent alkaline anaesthetic solution to be available immediately prior to its use.

In accordance with the patent statutes we have described and illustrated two preferred embodiments of our invention, but it will be understood that various changes and modifications can be made therein without departing from the scope of the invention as defined by the appended claims.

We claim:

1. In combination with a multiple compartment ampule having two movable end disks and .a permanently fixed intermediate disk, a transspaced relation therein, two of said spaced disks being positioned at one end of said ampule to be successively penetrated by said piercing element, said lateral inlet means being spaced from said collar a distance substantially equal to the thickness of the end disk to be initially penetrated, one disk being positioned inwardly at one end of said ampule to form an open space outside the disk at said end, said open space being substantially illled by said inwardly positioned disk during said transierrence.

2. In combination with a hypodermic syringe, a transfer element having a hypodermic needle with a through passage axially thereof and having a hollow piercing needle, said hypodermic needle being in spaced relation from said piercing needle and being operatively connected with an end of said piercing needle, said transfer element having a spring actuated valve for closing the passage, 'said transfer element having a threaded end portion, said hypodermic needle having a collar fixed thereto, and a hollow threaded member housing said hypodermic needle and being in threaded engagement with said threaded end portion whereby rotation of said housing in one direction will cause the said hypodermic needle to move said valve from its seat to permit outflow oi the'contents of said ampule.

3. The invention as defined in claim 1, wherein said tubular casing is integral and concentric with said piercing needle and said collar to centralize said ampule in said transfer element during said transierrence.


Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US2457313 *Mar 5, 1945Dec 28, 1948Lockhart Marshall LHypodermic syringe
US2514575 *Feb 17, 1945Jul 11, 1950Hein Howard TIntroversion syringe
US2583743 *Oct 2, 1944Jan 29, 1952Margaret L LockhartHypodermic syringe
US2590895 *Nov 21, 1949Apr 1, 1952Scarpellino Louis AMyelographic needle
US2604095 *Dec 18, 1948Jul 22, 1952Nathan BrodyDisposable syringe
US2626603 *Sep 29, 1950Jan 27, 1953Daniel GabrielHypodermic syringe
US3098483 *Dec 29, 1961Jul 23, 1963Leo Pharm Prod LtdTwo-compartment hypodermic syringe for separate storing of more components
US3108591 *May 29, 1962Oct 29, 1963Bristol Mycrs CompanySyringe
US3735761 *Feb 11, 1971May 29, 1973Ampoules IncHypodermic devices
US3875012 *Jan 30, 1974Apr 1, 1975Wadley Res Inst & Blood BankApparatus and method for the detection of microbial pathogens
US3911916 *Oct 29, 1971Oct 14, 1975Peter A StevensSequential injection syringe
US3923058 *Jun 28, 1974Dec 2, 1975Kendall & CoMulti-chamber syringe
US3946732 *Jul 18, 1974Mar 30, 1976Ampoules, Inc.Two-chamber mixing syringe
US4031892 *Feb 13, 1976Jun 28, 1977Ampoules CorporationTwo-chamber mixing syringe
US4055177 *May 28, 1976Oct 25, 1977Cohen Milton JHypodermic syringe
US4062477 *Nov 30, 1973Dec 13, 1977L'orealContainer having flexible walls and two chambers which are kept separate until the container is opened
US5476449 *Jul 22, 1993Dec 19, 1995Richmond; Frank M.Needleless multi-liquid medicament delivery system with membranes
US20050137532 *Apr 28, 2004Jun 23, 2005Rolla Jose S.Unit to administer injectable medication manually or automatically
DE2455981A1 *Nov 27, 1974Jul 31, 1975Wadley Res Inst & Blood BankVerfahren und vorrichtung zur feststellung von pathogenen mikroben
U.S. Classification604/88, 604/236, 604/416
International ClassificationA61M5/24, A61J1/00, A61M5/34, B67B7/92, A61J1/20
Cooperative ClassificationA61J2001/2027, A61M5/347, A61M5/24, A61M2005/3128, A61J2001/201, A61J1/2093, A61M2005/2407, A61J1/2096, B67B7/92, A61M5/2448, A61M5/344
European ClassificationA61M5/24, A61J1/20F, B67B7/92, A61J1/20D