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Publication numberUS2257106 A
Publication typeGrant
Publication dateSep 30, 1941
Filing dateFeb 26, 1938
Priority dateFeb 26, 1938
Publication numberUS 2257106 A, US 2257106A, US-A-2257106, US2257106 A, US2257106A
InventorsChristiansen Walter G
Original AssigneeSquibb & Sons Inc
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Dermal lotion
US 2257106 A
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Description  (OCR text may contain errors)

Patented Sept. 30, 1941 2,257,106 v DERMAL LOTION Walter G. Christians'en, Glen Ridge,

N. J., as-

signor to E. R. Squibb & Sons, New York, N.'Y., a corporation of New York I No Drawing.

6 Claims.

Application February 26, 1938, Serial No. 192,796

This invention relates to dermal preparations, such as cosmetic, protective or medicinal lotions,

creams, and the like.-

' Numerous dermal preparations embody fixed oils, such as olive oil, as the base or film -forming ingredient. Such preparations, however, are not readily distributed over theskin, and cause an objectionable sense of oiliness. Moreover, these oils, being at best only slightly soluble in alcohol, can not be used as the base or film-forming ingredient of alcoholic dermal lotions.

It is the object of this invention to provide dermal preparations-especially alcoholic lotions embodying alcohol-soluble perfume materials and/or medicamentswhich spread readily over the skin and form a very thin, soft, pliable film causing no objectionable sense of oiliness.

It has been found that higher fatty acid esters of lower aliphatic monohydric alcohols, and notably ethyl oleate, are excellently suited for use as the base or film-forming ingredient of dermal preparations. Ethyl oleate, for example, is a light-colored, almost odorless, bland, oily substance, which has protective properties similar to those of olive oil and the unique characteristics of solubility in alcohol in all proportions and very low viscosity. Because of its very low viscosity, it spreads readily over the skin, leaving a very thin, almost indiscernible, soft, pliable, oily film causlng no objectionable sense of oiliness: being soluble in alcohol, it enables the provision of alcoholic dermal lotions which are especially easily distributed over the skin, much like a toilet water, and leave, on evaporation of the alcohol, a thin, uniform, and protective film of ethyl oleate either alone or in combination with desired medicament and/or cosmetic materials. Moreover, a baseof ethyl oleate enables the use of alcohol-soluble perfume materials and/or medicaments for lotions, and, especially in the case of hand lotions, enables desirable modifications by addition of glycerine and/or water without causing separation of the mixture.

The higher fatty acid esters of lower aliphatic mono-hydric alcohols, notably ethyl oleate, can be used as the base or film-forming ingredient of preparations embodying a dermal agent, inter alia, germicidal, fungicidal, emollient, anesthetic, cosmetic, pigmentary or coloring, and ray-absorbing substances, thus, the invention is applicable to dermal preparations such as the following: lotions, e. g. antiseptic, hand, skin-toning, calamine, and sunburn-preventive lotions; creams, e. g. cold, vanishing, massage, shaving, and lanolin creams; lotions for the treatment of ultravioletr afiections of the skin, such as acne, blackheads, athlete's feet, and psoriasis; insect-bite preparations; liquid face powders; and hand-cleansing pastes.

Among the other higher fatty acid esters of lower aliphatic monohydric alcohols used in the practice of this invention are The following examples are illustrative of the invention, the parts being by weight:

Example 1 A lotion for the treatment of affections of the skin is prepared by dissolving 10 parts of ethyl oleate in parts of alcohol, and adding Zparts of salicylic acid and 1 part of bergamot oil.

Example 2 An antiseptic lotion is prepared by dissolving 50 parts of ethyl oleate in 150 parts of alcohol, and adding 1 part of phenol, 10 parts of camphor,'2 parts of thymol, 3 parts of eugenol, and 1 part of oil of lavender. I

Example 3 A sun burn-preventive lotion is prepared by dissolving 15 parts of ethyl oleate in 85 parts of alcohol and adding 5 parts of menthyl salicylate and 1 part of oil of lavender.

Example 4 A hand lotion is prepared by dissolving 30 parts Example 5 A cold cream is prepared by adding a solution of 1 part of borax in 43 parts of water to a melted mixture of parts of ethyl oleate, 4 parts of spermaceti, and 30 parts of white beeswax, stirring the mixture until cold, and incorporating a perfume material into the emulsion so formed.

Example 6 A vanishing cream is prepared by adding 100 7 parts of a 2% aqueous solution of potassium hydroxide to a melted mixture of 20 parts of triplepressed stearic acid and parts of ethyl oleate, stirring the mixture until cold, and incorporating 1' part of a suitable perfume oil into the emulsion so formed; a

Example 7 A lotion for the treatment of skin infections I such as athlete's foot is prepared by suitably mixing 3.75 parts of salicylic acid, 7.7 parts 'of benzoic acid; 0.5 part of phenol, parts of ethyl stearate,'1 part oil of Wintergreen, and 73 parts. a of alcohol.

Example 8 A brushless shaving cream is prepared by pouring 675 grams of a 1.5% aqueous solution of potasslum hydroxide into a melted mixture of 300 grams stearic acid and 25 grams of butyl palmiv tate.

Example 9 An antiseptic lotion is prepared by dissolving 50 parts of isobutyl laurate in 150 parts of alcohol, and adding 1 part of phenol, 10 parts of camphor, 2 parts of thyrnol, 3 parts of eugenol, and 1 part oil of lavender.

The invention may be variously otherwise embodied, within the scope of the appended claims.

I claim:

medicament and a higher fatty acid ester of a 2,257,106 1. A dermal lotion essentially comprising a dermal agent and a higher fatty acid ester of a lower aliphatic monohydric alcohol in alcohol solutiqn, and adapted to form a film of the ester in 'combination'wlth the dermal agent.

2. A dermal lotion essentially comprising a dermal agent and ethyl oleate in alcohol solution,

and adapted to form a film of ethyl oleate in combination with the dermal agent,

3. A dermal lotion essentially comprising a lower aliphatic monohydric alcohol in alcohol so- "lution, and adapted to form a film of the ester in ultraviolet-ray-absorbingsubstance and a higher 5 fatty-acid ester of a lower aliphatic monohydric alcohol in alcohol solution, and adapted to form a film of the'ester in combination with the ultraviolet ray-absorbing substance.

6. A dermal lotion essentially comprising glyc erine and a higher fatty acid ester of a lower aliphatic monohydric alcohol in alcohol solution,

and adapted to form a film of theester in combination with the glycerine.

' WALTER G. CHRISTIANSEN.

Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US2498727 *Nov 23, 1946Feb 28, 1950Lanolin Plus Cosmetics IncIsopropyl palmitate solution of lanolin cosmetic
US2809166 *Oct 8, 1957 Skin cleanser composition
US2853423 *May 20, 1955Sep 23, 1958Olin MathiesonAerosol sun-screening composition
US2865859 *Nov 9, 1956Dec 23, 1958Irwin I LuboweSolubilizing of mineral, vegetable, animal oils for cosmetic, pharmaceutical and industrial purposes
US3122475 *Feb 25, 1960Feb 25, 1964Schaeppi Ag DrCirculatory adjuvant shell elements for cardiac glycoside suppository cores
US3873537 *May 28, 1971Mar 25, 1975Squibb & Sons Inc1-Imidocarbonyl-2-(1H)-pyridones and method of preparing same
US4016264 *Jul 14, 1975Apr 5, 1977The University Of UtahWart treatment with phosphonoacetic acid or derivatives thereof
US4883654 *Oct 6, 1988Nov 28, 1989Young Deborah ASkin desensitizer, menthol, eugenol
US5519059 *Aug 17, 1994May 21, 1996Sawaya; Assad S.Of isopropyl alcohol, isopropyl myristate, polyoxyethylene glycol and tolnaftate
DE4237367A1 *Nov 5, 1992May 11, 1994Beiersdorf AgAntimycotische kosmetische und dermatologische Zubereitungen mit einem Gehalt an Fettsäureestern
EP0186258A2 *May 17, 1985Jul 2, 1986Haviva RivkinLotion for blemished scin (comprising thymol)
WO1982000249A1 *Jul 14, 1981Feb 4, 1982S ReinkeEmulsion for facial massage and shaving
Classifications
U.S. Classification424/60, 514/163, 24/17.00R, 424/73
International ClassificationA61K8/30, A61Q17/04, A61K8/37, A61K31/21, A61Q17/02, A61K9/00, A61K47/14, A61K8/368, A61K31/23
Cooperative ClassificationA61Q17/02, A61K47/14, A61K8/368, A61K9/0014, A61K8/37, A61Q17/04
European ClassificationA61Q17/04, A61K9/00M3, A61Q17/02, A61K8/37, A61K8/368, A61K47/14