|Publication number||US2432946 A|
|Publication date||Dec 16, 1947|
|Filing date||Apr 11, 1946|
|Priority date||Oct 4, 1941|
|Publication number||US 2432946 A, US 2432946A, US-A-2432946, US2432946 A, US2432946A|
|Inventors||Marie Theunissen Francois Jean|
|Original Assignee||Teco Sa|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (3), Referenced by (50), Classifications (13)|
|External Links: USPTO, USPTO Assignment, Espacenet|
Dec. 16, 1947.v
F. J. M. THEUNISSEN Filed April 11, 1946 1. ///K 1 gm I a m 1 4 5 a I l 5 1 H H H 7.
62 Id A H m v 1 45 a I 7 P 5. H 4
- 0W5 70/9.- FRANCO/sum (VA/P14: mf'a/wwixv AGf/VT Patented Dec. 16, 1947 KBPH-REATUS FGRTHE USE? OF AEROSOLS Francois. Jean Marie. Tlleuni'ssen, Brussels, Belgi'um", as'signor to Societe Anonymc Teco, Bois- Application: April: 11, 19%;. Serial Notv 661,187- In. Belgium October 4-,,194-1- Section' 1 Public Law 690, August 8, 1946 Patent expires October 4, 1961 6 Glaims To permit the proper use of medicinal products in the. form of aerosols intended to be inhaled; it' is advisable t'obe able tocollect these in such mann'e'ras to have available a quantity of aerosols sufiicient fora complete treatment and to" be able to controland estimate theirdensity.
The presentinvention has for its object to pro vide an apparatus permittingthe colle'ctibnv of. aerosols'in quantity appropriate to the object in View, as also their control and efficient. utilisation.
The apparatus according to theinventionconp prises essentially a hermetically closed jar in which the aerosols are developed: or into which they are conveyed and from which they can pass out through a tube the extremity of which opens out on the exterior of the jar and is connected to a mask or other means of inlri'alation used by the patient, whilst the other end opens into the upper part of a transparent ball or globe, or similar device, permitting the density of the aerosols to be. controlled.
Furthermore, it hasbeen found that the'quality of aerosols stored in. the jar of the apparatus according to the invention is improved by reason of the factvthat, in this j'ar, the aerosols are freed from theirlarger particles, the condensation of which is probably due to the combined action of the effect of the cold walls of the jar and the: drop in velocity of the flow of aerosols. The absence of large particles in the current leaving the jar is very advantageous, because the presence of large drops in the aerosols intended to be inhaled would cause the precipitation of the aerosols in the upper respiratory passages and would thus greatly reduce or even eliminate the useful efiect the treatment is intended to provide.
The invention will now be described in greater detail with reference to the accompanying drawings which by way of example show sectional views of two embodiments of the apparatus according to the invention.
This apparatus comprises a jar I of suitable capacity closed hermetically by a cover 2. In the example illustrated, the aerosol generator 3 is suspended from the cover and is in the interior of the apparatus, its tubing 8 being connected to a source of compressed air or other gas. This generator may also be arranged externally of the jar and supply aerosols into the latter through a tube.
A transparent globe 4, for example of glass, is mounted, for example by means of screws on the cover 2 and communicates with the jar l. One of the ends of a bent tube projects into the upper" part. of the. globe while its. other end: 1 projectsexternally of thewjanto be connected, for example. by means of a. flexible tube, to: a gas mask; 9; (Fig.1). without inspiration valve or' to some other: device used by the patient for the inhalation of the aerosols;
The means: for generating: the aerosols. canbe any know-ntype of aerosollgenerator; Preferably it should be of the type which efie'cts. the" pulverization of the liquid bymeans' oia'. compressed air jet or pulverizer; in: which the: compressed air in aspirati-ng' or ins delivering on mixing: with the liquid; projects the same with extreme violence into the surrounding air. A suitable generator is disclosed in French. PatentNo. 905,303 issued April: 9,. 1945 to Leonard; Bon-ameau.
Before: emerging through the. tube 5, the aerosols must necessarily pass. through the: glass globe: 4i By'me'ans' of? a comparison charter by means. of. ground or frosted glasses, the density of the aerosols can be checked by comparing the opacity of the. globe: containing: the aerosols with that ofv the saidchart or of the said ground or frosted glasses; Naturally; any other means of control. can-be substitutedfor the glass globe, for example a. photometer permitting very precise measurem'entsa.
The cover 2 also carries a tube 6 which p=rojects into the jar I, which permits communication with the atmosphere and which may be closed or provided with an inspiration valve depending on the use made of the apparatus which may be used either in closed circuit or in open circuit.
In the first case, the tube 6 and the expiration valve of the mask are closed, whilst an absorbent cartridge for carbonic acid is inserted in the flexible tube which, as indicated above, connects the end 1 of the U-shaped tube to the gas mask 9, or it is inserted in the intake opening of the gas mask. The patient thus inhales from and exhales into the hermetically sealed jar I which has been previously filled with aerosols. This method of operation is suitable when a small number of inhalations suffices to obtain the effect sought by means of the treatment.
When a more prolonged treatment is necessary, the apparatus is used with open circuit. In this case, the presence of the tube 6 is necessary. When the tube 1 is connected to a gas mask 9 (Fig. l) the latter must be provided with an expiration valve l0, and an inspiration valve H may be provided on the mask or in the tube 6 for avoiding the escape of aerosols. In the apparatus shown in Fig. 2, the tube 1 is provided with a mouth-piece [2 instead of being connected 3 to a gas mask. The expiration valve is arranged at the end of the tube 1, while the inhalation valve II is arranged at the lower end of the tube 6. When the jar l is filled with aerosols to the required density, the inhalations commence, the generator 3 continuing to function.
The compressed air (or other gas) necessary for the production of the aerosols may in particular be supplied by a hand pump or electric compressor or simply drawn from a compressed air flask provided with an expansion valve.
It will be understood that the device according to the invention may be mounted, if desired with its source of compressed air on a carriage which may also carry the medicaments and the accessories necessary for the treatment.
What I claim is:
1. An apparatus for the use of medicinal aerosols, comprising a hermetically sealed jar, means for supplying this jar with medicinal aerosols, a device for permitting the density of the aerosols to be controlled and comprising a chamber directly opening into said jar, a delivery tube having one end opening into the upper part of said chamber and having its other end opening externally of the jar, and means for connecting said tube to inhalation means used by the patient.
2. An apparatus for the use of medicinal aerosols, comprising a hermetically sealed jar, means arranged in said jar for developing aerosols therein, a device for permitting the density of the aerosols to be controlled and comprising a chamber directly opening into said jar, a delivery tube having one end opening into the upper part of said chamber and having its other end opening externally of the jar, and means for connecting said tube to inhalation means used by the patient.
3. An apparatus for the supply of medicinal aerosols, comprising a hermetically sealed jar, means for supplying this jar with medicinal aerosols, a transparent globe mounted on the top of said jar and directly opening into the latter, and a delivery tube extending into said globe and having one end opening into the upper part of the latter, its other end opening externally of the jar, and means for connecting said tube to inhalation means used by the patient.
4. An apparatus according to claim 3, in which the transparent globe is fixed in a detachable manner to the top of said jar.
5. An apparatus for the use of medicinal aerosols, comprising a jar, means for supplying this jar with medicinal aerosols, a device for permitting the density of the aerosols to be controlled and including a chamber directly opening into said jar, a pipe dipping into said jar and opening to atmosphere, a delivery tube having one end opening into the upper part of said chamber and having its other end opening externally of the jar, means for connecting said tube to inhalation means used by the patient and comprising an exhalation valve, and an inhalation valve arranged between the outer ends of said tube and. said pipe.
6. An apparatus for the use of medicinal aerosols, comprising a jar, means for supplying this jar with medicinal aerosols, a device for permitting the density of the aerosols to be controlled and including a chamber directly opening into said jar, a pipe dipping into said jar and opening to atmosphere, a delivery tube having one end, opening into the upper part of said chamber and having its other end opening externally of the jar, a mouth-piece adapted to said tube for permitting inhalation of aerosols by a patient, an exhalation valve arranged be tween said mouth-piece and the outlet of said tube, and an inhalation valve arranged between said mouth-piece and the inlet of said pipe.
FRANCOIS JEAN MARIE 'IHEUNISSEN.
REFERENCES CITED The following references are of record in the file of this patent:
UNITED STATES PATENTS Number Name Date 1,202,877 Margan Oct. 31, 1916 2,230,342 Zabban Feb. 4, 1941 FOREIGN PATENTS Number Country Date 92,276 Austria Apr. 25, 1923
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US1202877 *||Dec 18, 1915||Oct 31, 1916||Willard F Clark||Anesthesia apparatus.|
|US2230342 *||Oct 21, 1938||Feb 4, 1941||Benvenuto Zabban||Device for the production of artificial fogs|
|AT92276B *||Title not available|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US2845928 *||Jan 28, 1953||Aug 5, 1958||Misto2 Gen Equipment Co||Bronchopulmonary therapeutic apparatus|
|US2869188 *||Jun 6, 1950||Jan 20, 1959||Misto2 Gen Equipment Co||Medicinal inhalant atomization|
|US3350318 *||Feb 18, 1964||Oct 31, 1967||Fmc Corp||Method of producing detergent composition|
|US3744771 *||Jul 20, 1970||Jul 10, 1973||Ahldea Corp||Disposable liquid entraining system|
|US4173977 *||Mar 25, 1977||Nov 13, 1979||Cavitron Corporation||Aerosol interface|
|US4318397 *||Dec 31, 1979||Mar 9, 1982||Matsushita Seiko Co., Ltd.||Atomizing apparatus|
|US5320714 *||Feb 16, 1991||Jun 14, 1994||Byk Gulden Lomberg Chemische Fabrik Gmbh||Powder inhalator|
|US5645049 *||Jul 5, 1994||Jul 8, 1997||Trudell Medical Limited||Exhalation valve for face mask with spacer chamber connection|
|US5813401 *||Oct 15, 1996||Sep 29, 1998||Radcliff; Janet H.||Nebulizer automatic control valve|
|US5988160 *||Apr 25, 1997||Nov 23, 1999||Trudell Medical Limited||Exhalation valve for face mask with spacer chamber connection|
|US7004162||Sep 30, 1999||Feb 28, 2006||Canadian Monaghan, Ltd.||Exhalation valve|
|US7013896||May 6, 2002||Mar 21, 2006||Trudell Medical International||Mask with inhalation valve|
|US7084355||Apr 8, 2003||Aug 1, 2006||International Business Machines Corporation||Multilayer printed circuit board|
|US7448653||Jun 10, 2005||Nov 11, 2008||Value Plastics, Inc.||Female connector for releasable coupling with a male connector defining a fluid conduit|
|US7770939||Jul 23, 2008||Aug 10, 2010||Value Plastics, Inc.||Female connector for releasable coupling with a male connector defining a fluid conduit|
|US7806139||Jan 20, 2006||Oct 5, 2010||Value Plastics, Inc.||Fluid conduit coupling assembly having male and female couplers with integral valves|
|US7878553||Apr 27, 2009||Feb 1, 2011||Value Plastics, Inc.||Releasable connection assembly for joining tubing sections|
|US8113546||Aug 9, 2010||Feb 14, 2012||Value Plastics, Inc.||Latching female fluid tubing coupler|
|US8235426||Jul 3, 2008||Aug 7, 2012||Nordson Corporation||Latch assembly for joining two conduits|
|US8397756||Sep 29, 2010||Mar 19, 2013||Nordson Corporation||Fluid conduit couplers with depressible latch mechanism|
|US8448994||Aug 6, 2012||May 28, 2013||Nordson Corporation||Latch assembly for joining two conduits|
|US8596688||Jul 6, 2009||Dec 3, 2013||Nordson Corporation||Latch assembly for joining two conduits|
|US9046205||Dec 22, 2010||Jun 2, 2015||Nordson Corporation||Fluid connector latches with profile lead-ins|
|US9388929||Dec 22, 2010||Jul 12, 2016||Nordson Corporation||Male bayonet connector|
|US9464741||Dec 22, 2010||Oct 11, 2016||Nordson Corporation||Button latch with integrally molded cantilever springs|
|US9732891||Mar 27, 2016||Aug 15, 2017||General Electric Company||Male bayonet connector|
|US20030214797 *||Apr 8, 2003||Nov 20, 2003||International Business Machines Corporation||Multilayer printed circuit board|
|US20040014917 *||Sep 27, 2001||Jan 22, 2004||Thomas Eberle||Catalyst support, production and use thereof in the polymerization of olefins|
|USD629894||Jan 6, 2010||Dec 28, 2010||Value Plastics, Inc.||Male body of connector for fluid tubing|
|USD630320||Jan 6, 2010||Jan 4, 2011||Value Plastics, Inc.||Connector for fluid tubing|
|USD634840||Jan 6, 2010||Mar 22, 2011||Value Plastics, Inc.||Female body of connector for fluid tubing|
|USD645547||Nov 30, 2010||Sep 20, 2011||Value Plastics, Inc.||Male quick connect fitting|
|USD649240||Dec 9, 2009||Nov 22, 2011||Value Plastics, Inc.||Male dual lumen bayonet connector|
|USD650478||Dec 23, 2009||Dec 13, 2011||Value Plastics, Inc.||Female dual lumen connector|
|USD652510||Feb 11, 2011||Jan 17, 2012||Value Plastics, Inc.||Connector for fluid tubing|
|USD652511||Feb 11, 2011||Jan 17, 2012||Value Plastics, Inc.||Female body of connector for fluid tubing|
|USD654573||Nov 19, 2007||Feb 21, 2012||Value Plastics, Inc.||Female quick connect fitting|
|USD655393||Jun 23, 2009||Mar 6, 2012||Value Plastics, Inc.||Multi-port valve|
|USD663022||Feb 11, 2011||Jul 3, 2012||Nordson Corporation||Male body of connector for fluid tubing|
|USD698440||Jul 29, 2011||Jan 28, 2014||Nordson Corporation||Connector for fluid tubing|
|USD699840||Jul 29, 2011||Feb 18, 2014||Nordson Corporation||Male body of connector for fluid tubing|
|USD699841||Jul 29, 2011||Feb 18, 2014||Nordson Corporation||Female body of connector for fluid tubing|
|USD709612||Dec 23, 2011||Jul 22, 2014||Nordson Corporation||Female dual lumen connector|
|USD712537||Dec 17, 2013||Sep 2, 2014||Nordson Corporation||Connector for fluid tubing|
|USD749195||Jul 8, 2014||Feb 9, 2016||Usui Kokusai Sangyo Kaisha Limited||High pressure fuel injection pipe|
|USD749196||Jul 8, 2014||Feb 9, 2016||Usui Kokusai Sangyo Kaisha Limited||High pressure fuel injection pipe|
|USD749703||Jul 8, 2014||Feb 16, 2016||Usui Kokusai Sasngyo Kaisha Limited||High pressure fuel injection pipe|
|USD764640||Jul 8, 2014||Aug 23, 2016||Usui Kokusai Sangyo Kaisha Limited||High pressure fuel injection pipe|
|USD785790||Jan 25, 2016||May 2, 2017||General Electric Company||Male dual lumen bayonet connector|
|WO1991012040A1 *||Feb 16, 1991||Aug 22, 1991||Byk Gulden Lomberg Chemische Fabrik Gmbh||Powder inhalator|
|U.S. Classification||128/206.21, 128/207.14|
|International Classification||B01F3/04, A61M11/06, A61M15/00|
|Cooperative Classification||A61M2015/0018, A61M15/00, B01F3/04007, A61M2015/0016, A61M2015/0015, A61M11/06|
|European Classification||B01F3/04B, A61M15/00|