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Publication numberUS2494456 A
Publication typeGrant
Publication dateJan 10, 1950
Filing dateMar 18, 1946
Priority dateMar 18, 1946
Publication numberUS 2494456 A, US 2494456A, US-A-2494456, US2494456 A, US2494456A
InventorsKathleen S Still
Original AssigneeKathleen S Still
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Container
US 2494456 A
Abstract  available in
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Claims  available in
Description  (OCR text may contain errors)

Jan. 10, v1950 K. s. sTll..| 2,494,456

CONTAINER Filed March 18, l194e;

Patented Jan. 10, 1950 UNITED STATES? PATENT OFFICE CONTAINER Kathleen S: Still,Y Chicago, Ill.

Application March 18; 1946, Serial No'. 655,048

6 Claims,... Y(Cl. 12S-272) This invention -relates to a--container and more particularly to a multi-compartmented container primarily intended-for sterile --pharmaceutical or medicinal products.-

Certain pharrnaceuticals.consist of materials which are stable indefinitely or for a reasonable length of time, but kwhich-when in solutionbecome unstable and deteriorate; for example, penicillin, many of;the.arsenicals,-certain hormones,

and other labile materials. At the present time able to--m-ix two liquids at-the'time of use-andi" not before.

The present device permits the solution of a solid in a solvent without any contact with the outside air, or the mixing of two solutions in the same manner. This is made possible by providing a multi-chambered container comprising two transparent flasks, preferably of glass, one inside the other, with each having a substantially axial opening in one end thereof, preferably the top, the open ends being contiguous so that a hypodermic needle can be passed through both at one time, and then sealing these openings with diaphragrns of well-known form. When the container is designed to hold more than one dose so that a part only of the contents will be withdrawn from time to time the outside diaphragm, at least, should be self-sealing so as to keep out air and other materials. When the container is designed to hold only a single dose none of the diaphragme need be self-sealing unless desired. A hypodermic needle may be passed through both diaphragms to the inner container or iiask, the proper amount of material drawn into it and then the needle withdrawn into the chamber of the outer ask for addition of the interior material to the solution or solid. Obviously, the roles of the two asks may be reversed,

since the needle may be rst filled from the outer container and then the contents ejected into the internal container.

The invention will be described as related to the embodiments shown in the accompanying drawings. Of the drawings Fig. 1 is a vertical 2, section taken substantiallythroughthe center ofa container embodying the invention; Fie'. 2 is-fa plan View of the container of Fig. l; Fig. 3 isa horizontal section-taken-along line 3 3 off-Figa@ 1; and Fig. 4 is afragmentary vertical-*sectionU taken substantially through the center of a con-- tainer showing a second embodiment of the invention.

The-container of Figsyl to 3 comprises-acentra1 ask le, an outer, larger flaskl I, a self-seal ing puncturable diaphragm I2 closing off the mouth I3 of the inner iia'sk- Ill, and a stopper'III- l over the mouth I5- of the Aouter ask' II. The 2 stopper ill includes'alsecond'selfesealing pun`cturable diaphragm- I6. The two flasks I0 andY II have a common bottom I'I, andthe two flasks" are-substantially coaxial with the mouths I3 and* I5 also 4coaxial and atV corresponding ends of the flasks-'-v The stopper I4 has-aV depending portion I8 on the outside of the mouth` I5 and a second depending portion IS on the-inside of themoutlrIS.V The; diaphragm'-v I6 extends acrossthe top ofV the stopper and has a depressed section 2B at substantially the center to reduce the thickness of the diaphragm at this point.

The interior 2l o f the inner ask I0 may contain a liquid or a solid, while the space 22 between the inner flask I0 and the outer ask II may be filled with a solid or a liquid. When the container is in use at least one of the spaces 2l and 22 must contain a liquid.

When the container holds two liquids as shown, a hypodermic needle 23 may be inserted through the diaphragm I B and through the diaphragm I2. Some of the liquid may be withdrawn from the central flask I'II into the needle 23 and then ejected into the liquid in the space 22 between the two flasks. Here complete mixing may be obtained by shaking the container, and the resulting solution may then be drawn into the needle 23. This is only one Way of using the container, as the roles of the two asks may be reversed if desired. Also one flask may contain liquid While the other one contains solid. Then the liquid would be drawn into the needle, injected into the compartment containing the solid, the two materials mixed, and the resulting solution or dispersion drawn into the needle.

The embodiment shown in Fig. 4 is similar to that just described, but requires a different type closure for the two asks. In this second embodiment the stopper II4 is open at the top but has a depending portion |24 extending down from inside the mouth II5 of the outer flask to cover 3 the outer surface of the mouth H3 of the inner flask. At the bottom of the depending portion 124 there is located a diaphragm H2 closing off the mouth of the inner flask.

In this second embodiment of the invention the needle |23 is inserted into the two flasks in substantially the same manner as described above. Howeveiyin this case the needle must be inserted through the depending portion 124 of the stopper! I4.

The diaphragms i2, I6, H2, and 124 may be made of any inert puncturable material and may or may not be self-sealing. These materials are well-known in the art.

Having described my invention as related to the embodiments set out in the accompanying drawings, it is my intention that the invention be not limited by the details of description unless otherwise specied, but rather be construed broadly within its spirit and scope as set out in the accompanying claims.

VI claim:

1. A container comprising at least two transparent flasks with one inside the other, openings at corresponding ends of the flasks with the openings being spaced from each other, and puncturable diaphragms iixed in position and closing each opening, with the openings being axially aligned, and the flasks are provided with a bottom common to both.

2. A container comprising two transparent flasks one inside the other and coaxially aligned, axial openings at corresponding ends of the flasks with the openings being spaced from each other, and puncturable diaphragms fixed in position and closing each opening, with the two asks having a single bottom common to both.

3. The container of claim 2 wherein the sides of the two flasks are spaced from each other.

4. A container comprising a transparent flask having a neck portion and an opening, a second transparent flask of smaller diameter Within the iirst flask also having a neck portion and an opening, said iiasks having a common bottom to provide an integral structure with the openings being at corresponding ends of the flasks and spaced from each other, and self-sealing puncturable diaphragms fixed in position and closing each opening.

5. A container comprising a transparent flask having a neck portion and an opening, a second transparent flask of smaller diameter within the first flask also having a neck portion and an opening, said two flasks being joined together to make an integral structure, a puncturable diaphragm fixed in position and closing the opening of the inner bottle, and a puncturable well connecting the neck portions of the two bottles.

6. A container comprising an outer flask having an opening therein, at least one inner iiask within the outer ilask also having an opening, said ilasks being joined together to make an integral structure and said openings being on corresponding ends of the asks, and a puncturable diaphragm normally closing off each opening, said diaphragms being fixed in position` KATHLEEN s. STILL.

REFERENCES CITED The following references are of record in the iile of this patent:

UNITED STATES PATENTS Number Name Date 567,199 Rively Sept. 8, 1896 651,250 Howland- Sherman et al. June 5, 1900 1,706,335 Toch Mar. 19, 1929 2,028,751 Barton Jan. 28, 1936 2,321,998 Crouch et al. June 15, 1943 2,371,774 Nosik Mar, 20, 1945 2,385,648 Prager Sept. 25, 1945 FOREIGN PATENTS Number Country Date 332,827 Great Britain July 31, 1930

Patent Citations
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US567199 *Jan 28, 1896Sep 8, 1896 Fourths to john c
US651250 *Feb 19, 1900Jun 5, 1900Agnes S AdamAntiseptic food-coller.
US1706335 *Jun 3, 1927Mar 19, 1929Standard Varnish WorksReceptacle for paints, etc.
US2028751 *Apr 6, 1933Jan 28, 1936Charles W BartonContainer
US2321998 *Apr 4, 1942Jun 15, 1943Eastman Kodak CoTwo-compartment container
US2371774 *Mar 10, 1943Mar 20, 1945William A NosikPharmaceutical dispensing device
US2385648 *Jun 16, 1944Sep 25, 1945Prager MartinDouble container
GB332827A * Title not available
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US2612163 *Oct 9, 1950Sep 30, 1952Wilson Y NormanContainer for hypodermic preparations
US2615448 *Jul 8, 1950Oct 28, 1952Abbott LabMultiple chamber package
US2620085 *Jul 19, 1950Dec 2, 1952Columbia Protektosite Co IncPackaging device and cap-stopper closure
US2654948 *May 26, 1950Oct 13, 1953Mizzy IncDental cavity lining device
US2661742 *Aug 14, 1950Dec 8, 1953Hauduroy PaulMultiple container
US2746647 *Jul 27, 1950May 22, 1956Bridgeport Brass CoContainer with closure and dispensing valve
US2759597 *Oct 11, 1954Aug 21, 1956John MacgregorClinical thermometer cases
US2808053 *Jun 21, 1955Oct 1, 1957Baxter Laboratories IncSerology sample container
US2855933 *Apr 4, 1952Oct 14, 1958American Hospital Supply CorpFluid receptacle
US3033203 *Feb 15, 1957May 8, 1962Baxter Laboratories IncMethod of preparing a solution
US3059643 *Dec 10, 1954Oct 23, 1962Baxter Laboratories IncPumping apparatus
US3094234 *Jul 7, 1960Jun 18, 1963WarburgContainer
US3321097 *May 13, 1966May 23, 1967Solowey IdaBottle with two or more separate compartments
US3332421 *Aug 21, 1964Jul 25, 1967Upjohn CoCombination syringe and vial mixing container
US4467588 *Apr 6, 1982Aug 28, 1984Baxter Travenol Laboratories, Inc.Separated packaging and sterile processing for liquid-powder mixing
US4645073 *Apr 2, 1985Feb 24, 1987Survival Technology, Inc.Anti-contamination hazardous material package
US4657534 *Nov 4, 1985Apr 14, 1987Alcon Laboratories, Inc.Dual compartment, disposable, mixing and dispensing container
US5037623 *Mar 7, 1988Aug 6, 1991Steris CorporationSterilant concentrate injection system
US5209909 *Nov 18, 1991May 11, 1993Steris CorporationTwo compartment cup for powdered sterilant reagent components
US5395365 *Mar 22, 1993Mar 7, 1995Automatic Liquid Packaging, Inc.Container with pierceable and/or collapsible features
US5431174 *Apr 4, 1994Jul 11, 1995Via Medical CorporationMethod of fluid delivery and collection
US5435076 *Apr 16, 1993Jul 25, 1995Pharmacia AktiebolagInjection device
US5562591 *Sep 7, 1994Oct 8, 1996Compagnie Generale Des Matieres NucleairesReceptacle with a transport case in a pipe
US5662866 *Sep 25, 1995Sep 2, 1997Steris CorporationTwo compartment cup for powdered sterilant reagent components
US6325968 *Dec 23, 1998Dec 4, 2001Steris CorporationAntimicrobial composition delivery system with an integrated filler
US6571977 *Sep 20, 2001Jun 3, 2003Isaias GoncalezDual container
US20100282762 *May 10, 2010Nov 11, 2010Larry Wendall LeonardMobile Insulin Storage Cooler (MISC)
EP0647580A1 *Sep 12, 1994Apr 12, 1995Compagnie Generale Des Matieres Nucleaires (Cogema)Container with transport case in a pipe
WO1999015096A1 *Sep 17, 1998Apr 1, 1999Teva PharmaAmpoules holding an injectable liquid
WO1999025629A1 *Nov 16, 1998May 27, 1999Steven S LeeMulticompartment container for combination products
Classifications
U.S. Classification604/416, 215/10, 215/DIG.800, 220/62.18, 312/31, 206/219, 215/6
International ClassificationB65D81/32, B65D1/04, B65D51/00
Cooperative ClassificationB65D51/002, Y10S215/08, B65D81/3216, B65D1/04
European ClassificationB65D1/04, B65D51/00B, B65D81/32C