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Publication numberUS2527686 A
Publication typeGrant
Publication dateOct 31, 1950
Filing dateDec 26, 1945
Priority dateDec 26, 1945
Publication numberUS 2527686 A, US 2527686A, US-A-2527686, US2527686 A, US2527686A
InventorsSandberg Max H
Original AssigneeSandberg Max H
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Mouthwash
US 2527686 A
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Description  (OCR text may contain errors)

Patented Oct. 31 1950 MOUTHWASH Max H. Sandberg, MattapamlMass.

Application December 26, 1945, Serial No. 637,257

Claims.

This invention relates to mouth washes and particularly to compositions of this character which may be utilized to have a very eflicacious effect against dental caries.

Among the objects of the present invention is the production of compositions which can be utilized as mouth washes to prevent development of cavities in teeth.

Other objects and advantages will appear from the more detailed description set forth below, it being understood that such more detailed description is given by way of illustration and explanation only, and not by way of limitation since various changes therein may be made by those skilled in the art without departing from the scope and spirit of the present invention.

In accordance with the present invention it has been found that water soluble fluorides particularly of the alkali metals may be utilized in proper vehicles as a mouth wash or for related purposes, in limited concentrations in such mouth washes, to have a beneficial effect against development of cavities in teeth. The fluorides employed are desirably alkali metal fluorides of which ammonium fluoride or ammonium bifluoride has been found to be the best, while the sodium fluoride can be utilized. Potassium fluoride is the less efficacious. The fluoride is utilized in the vehicle which enables it to be carried into the enamel rods.

In such composition there is employed papain which digests proteins and malt or diastase such as takadiastase which digests starches. These ferments may be employed in such composition and do not interfere with each other. Other ferments cannot be employed in lieu of the particular ferments mentioned above and those set forth, namely, the papain and malt must be employed to give the most desirable results in accordance with the present invention. Such ferments together with the fluorides are desirably used in an aqueous composition which also contains zinc chloride and formaldehyde, as for example, commercial formalin. The most desirable proportions have been found to be 1 mole of fluoride to 1 mole of zinc chloride to 1 mole of formaldehyde but other ratios may be employed. The amount of fluoride present should be carefully controlled and should lie within about to 30 grains per gallon of the final solution. Less than 15 grains per gallon does not give any substantial effect while more than 30 grains tends to give a mottling effect. The preferred range is from 15 to 25 grains per gallon.

The stated ingredients are desirably used in an aqueous vehicle and since zinc chloride has a tendency to decompose in the presence of water, a water-soluble non-toxic alcohol may desirably be added to prevent this efiect. Ethyl alcohol is preferred, isopropyl and similar alcohols may be employed. Variation in the amount of alcohol and water proportions may, of course, be employed, but less alcohol than that indicated tends to give some undesirable feeling on the gums.

Flavoring components as desired may be employed such as the flavoring oils like oil of cassia, oil of cloves, and saccharin may be included in small amounts. The composition may be colored with any suitable dye. If desired to impart a Wintergreen aroma, this may be done by permitting the composition to stand within an atmosphere containing such oil of Wintergreen for a period of about one week.

The following is a preferred formula:

Parts Zinc chloride 2 Formalin (commercial) .5

Papain -l 100 Malt 100 The flavoring ingredients and vehicle components include:

Parts Oil of cassia 1.5 Oil of cloves .5

Saccharin .5 Ethyl alcohol 40 'Water 1000 The materials may be mixed in any desired way and the fluoride added to produce the stated concentration of from 15 to grains per gallon of solution, desirably 25 grains of sodium or ammonium fluoride being added for this purpose. While the fluoride may be incorporated together with all of the other ingredients, it is desirable to add it as the final component. The parts given in this example are by weight.

Compositions produced in accordance with the present invention have been proven to be a specific in preventing the formation of dental caries. This invention being a prophylactic only, does not have any action .on dental caries that are in active progress.

Having thus set forth my invention, I claim:

1. A mouth Wash containing zinc chloride, formaldehyde, papain, malt and water, and an alkali metal fluoride in an amount of from 15 to 30 grains per gallon of solution.

2. A composition as set forth inclaim 1,-in which the fluoride is ammonium fluoride.

(3. A composition as set forth in claim 1, in which the fluoride is sodium fluoride.

4. A mouth wash as set forth in claim 1 containing an amount of a non-toxic aliphatic alcohol sufiicient to prevent decomposition of the zinc chloride.

5. A mouth wash containing the following components in parts by weight: zinc chloride 2, formalin .5, papain 100, malt 100, ethyl alcohol 40, water 1000, and an alkali metal fluoride in an amount of 25 grains per gallon of solution.

MAX H. SANDBERG.

REFERENCES CITED The following references are of record in the file of this patent:

Number 0 Number 4 UNITED STATES PATENTS Name Date Monroe Dec. 29, 1925 Cross Jan. 16, 1934 FOREIGN PATENTS Country Date France Dec. 1, 1910 Great Britain of 1914 Austria Apr. 10, 1922 Great Britain Apr. 13, 1942

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US1567974 *Jun 1, 1923Dec 29, 1925Wesley Monroe CharlesTreatment of pyorrhea
US1943856 *Jul 10, 1929Jan 16, 1934Silica Products CompanyDental preparation
AT87896B * Title not available
FR420705A * Title not available
GB544405A * Title not available
GB191403034A * Title not available
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US2829086 *Sep 21, 1954Apr 1, 1958Colgate Palmolive CoDental preparations comprising higher aliphatic perfluorinated acid compounds
US2913373 *Aug 28, 1957Nov 17, 1959Fay Weisz GeraldineFluoride mouth wash composition
US3072532 *Nov 4, 1958Jan 8, 1963Innerfield IrvingAdministration of enzymic composition
US3852432 *Aug 21, 1972Dec 3, 1974Department Of Health EducationDiagnostic device and method of treatment
US4082841 *Oct 29, 1976Apr 4, 1978Lever Brothers CompanyZinc salt and an enzyme
US4096241 *Jun 24, 1976Jun 20, 1978Ed. Geistlich Sohne A.G. Fur Chemische IndustrieBactericides for prevention and treatment of parodontosis
US4152418 *Dec 1, 1977May 1, 1979Lever Brothers CompanyZinc and enzyme mouthwash and mouthwash concentrate for reducing dental plaque and calculus formation
US4339432 *Feb 17, 1981Jul 13, 1982Lever Brothers CompanyOral mouthwash containing zinc and glycine
US4416867 *Feb 10, 1982Nov 22, 1983Lever Brothers CompanyZinc salt, glycine
US4469674 *May 2, 1983Sep 4, 1984Richardson-Vicks Inc.Stable oral compositions containing zinc and fluoride compounds
US4473550 *Jan 3, 1983Sep 25, 1984Rosenbaum Robert SBactericidal compositions and methods
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US5002970 *Apr 18, 1988Mar 26, 1991Eby Iii George AFlavor masked ionizable zinc compositions for oral absorption
US5405836 *Mar 2, 1993Apr 11, 1995Nabisco, Inc.Pet foods with water-soluble zinc compound coating for controlling malodorous breath
US7582418Nov 3, 2005Sep 1, 2009Albion Laboratories, Inc.Antimicrobial chelates
US7687650Dec 29, 2006Mar 30, 2010Jr Chem, LlcCopper-zinc malonates; dermatology
US7867522Dec 29, 2006Jan 11, 2011Jr Chem, LlcTopically applying one or more copper or zinc salts and/or copper-zinc compounds or complexes, particularly copper-zinc malonate; increases levels of collagen, elastin, tropoelastin, and/or elastic fibers
US7897800Jan 29, 2007Mar 1, 2011Jr Chem, LlcChemical compositions and methods of making them
US7927614Jun 14, 2006Apr 19, 2011Jr Chem, LlcAnti-aging treatment using copper and zinc compositions
US7939306May 12, 2008May 10, 2011Colgate-Palmolive CompanyAntibacterial dentifrice exhibiting antiplaque and breath freshening properties
US8148563Feb 19, 2010Apr 3, 2012Jr Chem, LlcChemical compositions and methods of making them
US8273791Dec 10, 2008Sep 25, 2012Jr Chem, LlcCompositions, kits and regimens for the treatment of skin, especially décolletage
US8505730Aug 23, 2012Aug 13, 2013Jr Chem, LlcCompositions, kits and regimens for the treatment of skin, especially décolletage
USRE33465 *Apr 4, 1986Nov 27, 1990 Zinc gluconate
EP0075446A2 *Sep 16, 1982Mar 30, 1983Johnson & Johnson Products Inc.Anticaries composition
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WO1997040812A1 *Apr 24, 1997Nov 6, 1997Warner Lambert CoEnhanced zinc containing oral composition
Classifications
U.S. Classification424/50, 514/696, 424/58, 424/642, 424/52
International ClassificationA61K8/21, A61K8/30, A61K8/33, A61K8/96, A61K8/19, A61K8/27, A61K8/66, A61Q11/00, A61K8/97
Cooperative ClassificationA61K8/97, A61K8/66, A61Q11/00, A61K8/27, A61K8/21, A61K8/33
European ClassificationA61Q11/00, A61K8/21, A61K8/66, A61K8/97, A61K8/33, A61K8/27