Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.


  1. Advanced Patent Search
Publication numberUS2561071 A
Publication typeGrant
Publication dateJul 17, 1951
Filing dateSep 21, 1949
Priority dateSep 21, 1949
Publication numberUS 2561071 A, US 2561071A, US-A-2561071, US2561071 A, US2561071A
InventorsPrisk Howard Conley
Original AssigneePrisk Howard Conley
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Holder for subcutaneous administration of medicaments
US 2561071 A
Abstract  available in
Previous page
Next page
Claims  available in
Description  (OCR text may contain errors)

July 17, 1951 H. c. PRISK 2,561,071

HOLDER FOR SUBCUTANEOUS ADMINISTRATION OF MEDICAMENTS Filed Sept. 21, 1949 I 3mm 15! Pris/6 (Etern y Patented July 17, 1951 HOLDER FOR SUBCUTANEOUS ADMINIS- TRATION OF MEDICAMENTS Howard Conley Prisk, Westerville, Ohio Application September 21, 1949, Serial No. 116,963

3 Claims. 1

This invention is concerned with an improved device for holding and applying liquid pharmaceutical or biological compounds in direct contact with the surface of the skin for subcutaneous absorption into the human system.

It is common medical practice to introduce intravenously various preparations or medicaments, such as insulin, hormones, penicillin and.

many other preparations, including steroidal hormones, anti-biotics and the like, into the human system. Usually this operation requires the services of a physician, a graduate nurse or other similarly skilled technician, although self-administration is feasible and often practiced, as in the case of patients affected with diabetes. The use of hypodermic syringes in effecting such injections is disagreeable to many patients, even when handled by a skilled operator. The other alternative is the oral administration of preparations admitting of introduction into the alimentary tract. This method, however, is not altogeher satisfactory, in that certain preparations are destroyed, or their value substantially diminished, during passage through the alimentary tract. Also, this method is objectionable to many physicians in that dependence must be placed on the patient to self-administer medicines in the required quantities at definite intervals of time.

In accordance with the present invention, a

medicament in liquid form is contained in a carrier device which through adhesive means is placed on the body with the liquid medicament contained therein in direct contact with the outer surface of the skin, the body of the carrier being sufficiently flexible to conform with the movements of the human body or that region of the latter to which the carrier is applied, the carrier further including a flexible cap which collapses under atmospheric pressure as the medicament is absorbed or otherwise penetrates into the systerm.

I am aware that many patents have been granted on devices employed as surgical dressings or adhesive bandages, or in applying various medicaments to locally affected area such as wounds, cuts, burns, lacerations, etc. My present device is not concerned with the treatment of such localized afliictions, but is intended for introducing liquid pharmaceutical preparations into the blood stream through the skin. In other words, the device of the present invention acts as an instrument in a way comparable with that of the hyprodermic syringe, the difference being that whereas the hypodermic syringe pierces the skin and deposits a liquid directly into the body cavity, my device permits the liquid to enter said cavity slowly by absorption or direct penetration. In this way, a slow measured introduction of the medicament takes place with my improved device, which enables the human system to absorb and utilize the medicament at all times in proper quantities, instead of applying, as in the case of a hypodermic syringe, an over dosage at one injection and allowing the injection to diminish as the body functions. My device is also an improvement over administering medicines by the mouth, as its avoids deterioration and loss of the beneficial constituents of such medicines as a result of their attack by gastric juices and other bodily processes.

For a further understanding of the invention, reference is to be had to the following description and the accompanying drawing, wherein:

Fig. 1 is a vertical transverse sectional view taken through a medicine administering and holding device formed in accordance with the present invention; the device being shown in its complete form for holding in a sealed state therein biological or pharmaceutical solutions;

Fig. 2 is a similar view disclosing the device as it appears when applied to the surface of the skin;

Fig. 3 is a perspective view of the device.

Referring to the drawings, my improved medicine holding and administering device comprises a capsule 0, formed to provide a base ring 5, which may be composed of a fabric such as crinoline or other fibrous material, woven or matted, to possess stifiness but with a sufiicient degree of flexibility so that it will conform to the movements of that part of the body to which it is applied. The under surface, at least, of the ring 5 is coated with a pressure-sensitive adhesive, such as a rubber-base adhesive, by which the capsule is maintained in an applied position on the outer surface of the skin, and also to separably secure thereto a removable sealing strip 6, the latter being separated from the ring 5 immediately before the capsule device is applied to the skin.

Mounted on the ring 5 is the peripheral edge 1 of a cap 8. This cap is formed preferably from a flexible liquid-resisting material, for example, a sheet of regenerated cellulose such as cellophane, or one of the chlorinated rubbers known commercially as Pliofilm or tensolite. The cap 8 in association with the ring 5 and the sealing strip 6 provides a cavity within the capsule adapted for the reception of a medicament 9 in liquid form, the specific composition or uses of which being unimportant insofar as the present invention is concerned, except their ability to penetrate the human skin.

In the use of my improved capsule device, the base strip 6 is removed at the time of its application, so that the adhesive-bearing surfaces of the ring may be applied directly to the skin, as shown in Fig. 2. In this way, the liquid body 9 comes into direct contact with the skin so that it may be absorbedrintothe system; As the liquid body is absorbed, the cap 8 responds to atmospheric pressure and collapses, maintaining at all times close contact with the body of liquid vacua or sub-atmospheric pressures.

Thus with the use of the caps le,forming.the.

present invention, the rate of introduction of a and A precluding the formation within the capsule of' of the user of the device and a physician is assured that a patient is receiving a given medicament in" proper quantities. The. device -;eliminates the-necessity for cleaning and sterilizing hypodermic needles and overcomes one-of the difii'culitiesor'particular objectionsso frequently encountered in the self -administering of various medical compounds. 1 I

The medicament contained in the cap portion ofthe -applicator is preferably admixed. or dissolved in a compound such-as propylene glycol,

ethylene glycol, alcohol or a saline solution. Alsov there may be maintained in the solution-an electrolyte or catalyst which renders. the. region. or

skinuor membrane towhich the device is applied morereadilyprmeable-to the passage 'of the liq-. uid medicaments through dilation. ofs-dermal pas-- sages. Such anelectrolyte or catalyst may consist of" dilute hydrochloric acid in various: con.- centrations:- Other compoundssuitable for effecting such .dialysiss may include magnesium sulphate or sodium. chloride; Preferably, the, accompanying' article or container of the present inventionisapplied to a. thin part of the human skin, as in regions adjacent to body joints, as the shoulder, elbow or thelikep Various changes may be; made in my device without departing from the: spirit; and scope of.

the invention as the same has been defined in the the; upper surface of'said base member to overliethe'openin'g therein, said cap providing a cavity for the reception of a medicament, an adhesive applied to the under surface of said-base'member, and a removablesealing strip normally attached tothe-base member-by said adhesive and confining; said medicament within-the cavity of said 4 cap, said strip being removable from its sealing association with said base member to open the bottom of said cavity and the opening in said base member, whereby to enable the medicament contained within the cap to contact directly a selected region of the skin around which the device is positioned, the flexibility of the cap being such as to enable the same to flex inwardly to maintain closecontact thereof with the medicament as the volume of the latter progressively decreases in said cavity through absorption in the skin tissue.

2. Medicament holding and applying means comprising: a casing embodying a base and a fiexiblewalled cap, the latter forming a cavity for the reception of a medicament, and a removable sealing strip: normally. attached to the base, said strip beingremovable from its sealing association with said base to open the bottom of said cavity, thereby enabling the medicament contained within the cap to contact'directly a sealing region of the-skin around which the device is positioned;

the fiexibility of-the c'ap'bein'g such as to enable the walls thereof to flex: inwardly and: maintain.

close contact with the medicament as the supply.

humannbody for subdermali absorption comprise;

ing: :a base strip havingan under sidecoated with an adhesive, said stripubeingv formed intermedi. atelyL- thereof with i an opening; .a flexible walled.

cap .securedtonthe uppermsurfacepofi said basestrip toioverlie the-opening therein, said cap pro.- viding acavity forthe reception of-the medicarment, and a removable (sealing strip normally atrta-ched toxthe base member by: said adhesiveand, confining said medicamentwithin said cap, said strip being removable from; its adhesive: ass0cia--; ti0n;;with-. said'base-strip' to enable the medicament'containedwithinthecap to contact directly a selected region, of? the .skin, around which the deviceis positioned, theflexibility ofthematerial forming .thecap being such; 'asto enablesame toflex? inwardly 'tor maintainclosepressure contact with the-,medicament as; the volume ofthe latter progressively decreases in said- 'ca vity through absorptionin the skin tissue. and upon the presence; of anyatmospheric pressure differential on the inner and outer surfaces of the cavity.


REFERENCES. CITED The following references are of record in the file of this patent:

UNITED STATES PATENTS Number Name- Date 720,812 Johnson Feb. 17, 1903; 2,443,140

Larsen June 8, 1943-

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US720812 *Jan 12, 1901Feb 17, 1903Robert W JohnsonVaccination-shield.
US2443140 *Apr 11, 1946Jun 8, 1948Robert E LarsenBoil cup
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US2817335 *Jun 10, 1955Dec 24, 1957Thompson Thalmer JBandage and dressing
US3053255 *Dec 16, 1958Sep 11, 1962Meyer FriedrichProcess of percutaneously administering exact doses of physiologically active agents and composite unit therefor
US3651932 *Oct 9, 1969Mar 28, 1972Zahn Porzellan Kge Muhbauer &Duplex capsule for dental filling material
US3837340 *Jun 4, 1973Sep 24, 1974Lilly Co EliDevice for administering immunication against virus
US4127339 *Oct 19, 1976Nov 28, 1978Malacheski Joseph JDispenser package for fluent material
US4232671 *Jun 23, 1978Nov 11, 1980Crump Charles LSafety eyewash package and container therefor
US4341208 *Jul 14, 1980Jul 27, 1982Whitman Medical CorporationMoisture-retentive covering for ointment application
US4585452 *Apr 12, 1983Apr 29, 1986Key Pharmaceuticals, Inc.Transdermal systemic dosage forms
US4619652 *Aug 19, 1985Oct 28, 1986Alza CorporationDosage form for use in a body mounted pump
US4649075 *Aug 9, 1984Mar 10, 1987Leonora JostTransdermal and transmucosal vortexed foam devices and the method of making
US4655766 *Apr 17, 1986Apr 7, 1987Alza CorporationFluid imbibing pump with self-regulating skin patch
US4687481 *Mar 3, 1986Aug 18, 1987Biotek, Inc.Controlled release by way of membrane adhering to skin
US4710191 *Dec 16, 1985Dec 1, 1987Jonergin, Inc.Transdermal
US4801587 *Mar 2, 1987Jan 31, 1989Gene VossVasodilators
US4812305 *Nov 9, 1987Mar 14, 1989Vocal Rodolfo SWell medicine strip
US4822617 *Apr 10, 1987Apr 18, 1989Elan Corporation P.L.C.Drug delivery device
US4877618 *Mar 18, 1988Oct 31, 1989Reed Jr Fred DTransdermal drug delivery device
US4904475 *Feb 24, 1987Feb 27, 1990Alza CorporationTransdermal delivery of drugs from an aqueous reservoir
US4917688 *Jun 27, 1988Apr 17, 1990Nelson Research & Development Co.Bandage for transdermal delivery of systemically-active drug
US5139023 *Jun 2, 1989Aug 18, 1992Theratech Inc.Apparatus and method for noninvasive blood glucose monitoring
US5291887 *Jun 2, 1992Mar 8, 1994Anesta CorporationApparatus and methods for noninvasive blood substance monitoring
US5498417 *May 12, 1994Mar 12, 1996Coating Sciences, Inc.Transdermal delivery of appetite suppressant drug
US5962011 *Jun 24, 1997Oct 5, 1999Schering-Plough Healthcare Products, Inc.The device is useful for treating lesions or abnormal skin features such as corns, warts, calluses, bunions, actinic keratoses and hard hyperkeratotic skin as is often found on the face, arms, legs or feet.
US6676961Mar 6, 2002Jan 13, 2004Automated Carrier Technologies, Inc.Accomodates both small and large volume dosages
US7976867Dec 12, 2003Jul 12, 2011Schering-Plough Healthcare Products Inc.Multilayer; backing layer containing reservoir, covering with aperture , adhesive and lining
US8206738Sep 12, 2003Jun 26, 2012Corium International, Inc.Hydrogel compositions with an erodible backing member
US8273405Oct 7, 2011Sep 25, 2012A.V. Topcheiv Institute of Petrochemical Synthesis, Russian Academy of SciencesWater-absorbent adhesive compositions and associated methods of manufacture and use
US8481059Jun 24, 2009Jul 9, 2013A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of SciencesHydrogel compositions
US8481071May 29, 2012Jul 9, 2013Corium International, Inc.Hydrogel compositions with an erodible backing member
US8541021May 17, 2004Sep 24, 2013A.V. Topchiev Institute Of Petrochemical SynthesisBlend of methacrylic acid-methyl methacrylate copolymer, cellulose, polyvinyl alcohol, polysaccharides, collagen, polyvinyl amine, polyvinylpyrrolidone, and/or poly(N-alkylacrylamide); water swellable, film-forming; teeth whiteners; complementary oligomer hydrogen bonds to hydrophilic polymer
US8617647Aug 24, 2012Dec 31, 2013A.V. Topchiev Institutes of Petrochemical Synthesis, Russian Academy of SciencesWater-absorbent adhesive compositions and associated methods of manufacture and use
US8658201Jan 31, 2005Feb 25, 2014Corium International, Inc.Rapidly dissolving film for delivery of an active agent
US8728445May 1, 2002May 20, 2014A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of SciencesHydrogel Compositions
US8741331Jun 12, 2013Jun 3, 2014A. V. Topchiev Institute of Petrochemicals Synthesis, Russian Academy of SciencesHydrogel compositions with an erodible backing member
US8753669Aug 20, 2007Jun 17, 2014A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of SciencesTwo-phase, water-absorbent bioadhesive composition
US8784879Jan 14, 2010Jul 22, 2014Corium International, Inc.Transdermal administration of tamsulosin
US8821901Apr 5, 2010Sep 2, 2014A.V. Topchiev Institute Of Petrochemical Synthesis Russian Academy Of SciencesMethod of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components
US8840918Feb 5, 2003Sep 23, 2014A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of SciencesHydrogel compositions for tooth whitening
USRE44145Jun 10, 2005Apr 9, 2013A.V. Topchiev Institute Of Petrochemical SynthesisPreparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
EP0107575A1 *Oct 12, 1983May 2, 1984Laboratoires Fournier S.A.Percutaneous administration device of the active principle
EP0123539A2 *Apr 19, 1984Oct 31, 1984James Chester BrenemanImmune responses to ingestible substances
U.S. Classification424/449
International ClassificationA61K9/70
Cooperative ClassificationA61K9/7084
European ClassificationA61K9/70E2D