Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.

Patents

  1. Advanced Patent Search
Publication numberUS2587215 A
Publication typeGrant
Publication dateFeb 26, 1952
Filing dateApr 27, 1949
Priority dateApr 27, 1949
Publication numberUS 2587215 A, US 2587215A, US-A-2587215, US2587215 A, US2587215A
InventorsPriestly Frank P
Original AssigneePriestly Frank P
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Inhalator
US 2587215 A
Images(3)
Previous page
Next page
Description  (OCR text may contain errors)

Feb. 26, 1952 F. P. PRIESTLY INHALATOR 3 Sheets-Sheet l Filed April 27, 1949 INVENTOR. FRA/wf H P/Q/ISTLY 6 w /w s 4 Y Feb. 265, 1952 F. P. PRn-:sTLY

INHALATOR 3 Sheets-Sheet 2 Filed April 27, 1949 .ASSNG INVENTOR. P/e/S 71.)

HMM/KP A@ ATTORNEY.

Feb. 26, 1952 v F, P PRlEs-{LY 2,587,215

- INHALATOR Filed April 27, 1949 's sheets-sheet s Patented Fel). 26, 1952 UNITED= STATES PATENT OFFICE INHALATOR Frank P. Priestly, Chicago, Ill.

Application April 27, 1949, Serial No. 89,851 v (o1. 12s2o6 18 Claims.

This invention relates to devices for the diffusion and inhalation of therapeutic powders and more particularly to such devices of such simplicity that they may be used in the home Without need for a physicians presence or control.

It has recently been discovered that the inhalation of certain therapeutic powders, principally penicillin and the like, into the `nasal and/or oral passages has a highly beneficial effect in the treatment of certain diseases and infections. This is especially true in the treatment of sinusitis and infections of the throat and lungs.

Previous treatment using this type of material has included a mist treatment which required complicated apparatus including compressed oxygen in tanks and the like to be found only in a physicians officeA or hospitals. Later devices for the use of the powder or dust, as it is called, included masks similar to a respirator mask covering both the nose and mouth and having a container therein for the powder. This device is not completely satisfactory because patients object to the heavy and unattractive device, and too much of the drug is lost during infhalation.

A simple method of inhaling the dust is not very successful because penicillin and other powders are highly hygroscopic and cake together if the normal breath is exhaled across them. A device has been proposed using a small ball similar toV buckshct, which, upon inhalatiomstrikes the capsule or cartridge holding thepowder to jar a few grains into the stream of air being inhaled. However, this device must be removed from the mouth or nose before exhaling to avoid contact of the moist breath with the powder.

It is the purpose of my invention to provide an inhaler usable in the home which does not require a special technique for the use thereof. This is accomplished by isolating the main supply of the powder from the mixing or diffusion chamber and providing a means of transporting a measured amount of the powder from the supply chamber to the mixing chamber. Furthermore, I provide a spring means which causes a jarring action eachtime a new bit of the powder is carried to the mixing chamber. Moreover, my device is designed to use standard size capsules, which makes for a more economical use for -lling of medicament and isquite small so that it could be carried in a purse or pocket as simplyas a cigarette lighter or the like. My device is also quite inexpensive since itcan be made from stock sizes and formsofmater ialgwithout special for# mation, requiring, therefore, only a minimum of machine Work to form my device.

Other advantages of my invention, and the invention itself, will become apparent from the following description which is illustrated by the accompanying figures which form a part of this specification.

In the drawings:

Fig. 1 is an isometric View of one embodiment of my invention;

Fig. 2 is a top plan View of the push-button and slide mechanism disassembled from the rest of my device;

Fig. 3 is a longitudinal medial section of this embodiment of my invention showing the push button and slide in a retracted position;

Fig. 4 is a view similar to Fig. 3 showing the push button and slide in an inserted position;

Fig. 5 is a sectional view along line 5-5 of Fig. 3;

Fig. 6 is a sectional view along line 6-6 of Fig. 4;

Fig. 7 is a side elevational view of an alternative embodiment of my invention;

Fig. 8 is a vertical medial section of this latter embodiment;

Fig. 9 is a, top plan view of the rotary slide means;

Fig. 10 is a bottom plan view of my alternative embodiment;

Fig. 11 is a side elevational view of the 'slide means; l

Fig. 12 is a perspective view of a second alternative embodiment;

Fig. 13 is a vertical medial section of `this second alternative;

Fig. 14 is a sectional view on line |4--I4 of Fig. 13;

Fig. 15 is a sectional view on line I5-.|5, of Fig. 14; and y Fig. 16 isa vertical medial sectional view of a third alternative embodiment of my invention.

For the following description, reference is had to the figures throughout which like parts are designated by like reference characters.

Briefly, my invention comprises an inhaler composed of a body having two separate chambers, one for storing a supply of the powder to be inhaled, and` one inY Which a small amount of the powder is diffused in an airstream and from which it is led by a tube to the oral or nasal passages into which it is inhaled. Sliding means is provided to -carry the small, and measured, amounts of powder from the supply chamber to the mixing chamber, and to isolate the two chambers from each other so that whatever moisture gets into the mixing chamber from exhaled breath will not get to the supply of powder.

More specically, my rst embodiment as shown in Figs. 1-6 inclusive comprises a rectangular body I which may be made up of two pieces, an upper piece II and a lower piece I2, interlocked together as shown. The material indicated in the gures is a plastic material, and while I prefer to use a clear plastic for the body of my invention, the invention is not limited to a device made of this material and may assume4 other shapes than the rectangular.

The upper piece I I of the body contains a sup.- ply chamber I4 which is a cylindrical opening of a diameter such that a large size pharmacy capsule I5 will iit snugly therein. Near the bottom, the chamber -I4 is provided with a shoulder I6 so that the capsule I5 will not be inserted intoV the opening beyond that point.

A slot I'! is provided between the upper and.

lower pieces, in which a slide member I8. is slidably disposed. This slide member as best shown in Fig. 2 is a flat rectangular piece of corrosion resistant metal such as Duralumin or stainless has a multiple function; it not only acts as a guide for the slide to avoid binding of the slide against the side walls, but also prevents over travel of the slide7 therefore locating the opening I9 in its proper position at both ends of travel of the slide. It serves a further purpose in that as the opening I 9 is slid from its pcsition beneath the capsule I5, it is bisected by the stop 2|', thus loosening the powder in the opening and causing it to drop into the mixing chamber as hereinafter described. As a stop, it also serves to convey the impact of a quick release of the slide to the capsule and the powder therein, causing the powder to be loosened and jarred into the opening I9 of the slide IB.

A novel spring arrangement is used which facilitates. the assembly of the device. The slide is formed with an opening comprising essentially a large rectangular opening 22 having aY long tongue 23 and a shorter tongue 24 extending into it. A compression spring 21 is then inserted into the opening over the long tongue and compressed and allowed to spring over the shorter tongue. Thus the spring is completely held by the slide member which, with the push button 28, forms a discrete sub-assembly requiring no tools or spring holders to assemble into my device. Since the spring extends beyond the slide on the stop and bottom thereof. it is full-y effective to engage the two pieces II andv I2 and to urge the slide to, the left against the stop 2I as viewed in Figs. 3 and 4.

The lower piece I2 of the body contains the mixing or diffusion chamber 29 which is in the. form of a cylinder extending from one end 30 of the device. A circular opening 3I extends into the chamber 29 from the top of the piece I2 somewhat displaced from the supply chamber I4 and preferably immediately below the stop 2I. I'he end opening of the mixing chamber may be provided with screw or taper threads the spring 2?.

not shown into which an inhaling tube 33 may be threaded. Grooves 34 are cut in the wall of the opening and, in the case of threads, intersect the threads and extend beyond the end of the inhaling tube to allow air to enter the chamber and to become mixed with the powder. The air which so enters is, subsequently in this description, called primary mixing air.

The tube 33, which is threaded into the mixing chamber 29, is formed with a restriction 35 in the end thereof. This restriction causes a drop in pressure between the mixing chamber 29 and the interior of the tube when air is drawn therethrough. An opening 36 directly into the tube between the restriction 35 and the open end 31 of the tube is provided so that secondary mixing air will enter the stream at that point causing further turbulence in the air stream and better diiusion and pulverization of the powder than is possible with just the mixing which takes place in the chamber.

In use, the half capsule I5 filled with powder is inserted into the chamber I4, or the chamber I4 is lowered over the capsule to avoid spilling the powder. The device is then placed upright and the push button 28 is pressed inward, sliding the slide IS inward so that the periphery of the opening I9 engages the stop 2i compressing The slide is then permitted to snap back against the stop jarring some of the. powder into the `opening I9. Mot ing the slide in again carries the powder over the opening 3 I into which it drcps being broken up somewhat by the step 2I whih passes through the opening I9 as sho n in Fig. 6. This p;ocess may be repeated, or the powder in the mixing chamber ma;7 now be inhaled depending on the prescribed dosage.

To inhale the powder, the` open end 3l of the tube is placed in, the nostril or in the mouth and a deep breath is taken.. The air entering the oral or nasal cavities must be drawn through the grooves 34 and thel opening 36. The air entering the grooves stirs. up and mixes with the powder in the chamber 29 diffusing it and carrying it into the tube. However, as previously explained, the restriction causes a pressure drop and secondary air enters through the opening 36 causing further mixing. is then conducted to the oral or nasal cavities through the tube.

Another embodiment of my invention, the operation of which is the same .though the details of construction are somewhat different, is shown in Figs. 7-11. In this embodiment, the body 40 is a single cylindrical piece containing both the supply chamber 4I and the mixing chamber 42. The supply chamber 4I is formed the samey way as before with a shoulder 43, although it may be somewhat deeper than that in the previously described embodiment. The method of attaching the tube 33 and its formation, and the provisions. for primary and secondary mixing air are exactly the same. as in the previous. embodiment, except the tube may be bent as shown to account for the difference in orientation of the two devices in use. The mixing chamber is similar, also, except that it extends completely through the body 40,..

The slide membery 44 of this` embodiment is` a rotary sliding device, journalled on a cylindrical' pivot member 45 extending from the bottom 46 of the body 40. A spring washer 41 is used to urge this slide into close contact with the rbottom v'of' the body. kA plural-ity of' hollows 48 are TheA diffused mixturev formed in the upper surface of the slide which are adapted to register with the mixing and supply chamber to receive the powder and carry it from the supply chamber to the mixing chamber upon rotation of the slide. In order to provide a method of jarring the powder down into the hollows 48, and to index the slide 44 in its travel, a plurality of projections 49 is formed on the periphery of the slide. Each of the projections comprises a sloping rise portion and an abrupt drop 01T 52 at the bottom of which there may be provided a slight notch 53 as a detent for better indexing of the hollows. A spring member 54 inthe form of a bent leaf spring is provided having aY finger 55 to engage these projections. The spring 54 may be seated on the pivot 45 and fastened thereto by a screw 56 threaded into the pivot. An opening 51 in the spring may be provided to give access to the screw. As can be seen, the spring 54 serves additionally as a washer to hold the spring washer 41 in place.

The operation and use ofthe device is the same as previously described except that instead of sliding the push button in and allowing it to snap out, it is necessary with the latter device only to turn the slide member 44 and allow the spring 54 to snap off the drop off 52 to jar loose the powder.

A second alternative form of my device is illustrated in Figs. 12-15. In this embodiment, the body is of cylindrical shape and is of the push button slide type similar to the preferred embodiment. The body portion 69 is of cylindrical shape having an enlarged end 6|. A bore 62 extends through the body and is counterbored at 63 in the enlarged end 6| of the body to receive the push button 64 of the slide member 65. In this embodiment, I prefer to mount the spring 69 in the usual manner, engaging the bottom of an annular kerf 61 in the push button and the bottom of the bore 63 inthe bo dy. A longitudinal groove 93 is provided in the slide member which receives the end of a screw 69 threaded into the body. This screw serves as a stop and guide for the slide member similar to the stop 2| of the rst embodiment. It is easily removable, and thus the inhalator may be readily disassembled for cleaning. v

The powder carrying parts of this embodiment are similar to the first embodiment. The slide member 65 is shaped with a segmental portion 10 in extension from the push button 64 but preferably integral therewith. This portion is formed with an opening 1| and slot 12, similar to those in the slide of the first embodiment. A tongue 13 extends into the slot 12 to loosen the powder in a similar manner as in the first embodiment. In order to keep the powder in the opening, a partition 15 is provided having a horizontal wall 16 extending beneath the opening 1| when the slide is retracted. Directly over this wall 16 an opening 11 is formed for the capsule l5 which may be inserted against a shoulder 18 as before. A reinforcing sleeve 19 may be formed or fixed to the body to support the capsule in this position.

As best shown in Figs. 14 and 15, thebody is formed with grooves 89 on either side of the tongue 13 in which small extensions 32 are slidably disposed. These grooves extend into the capsule opening 11, and the extensions are adapted to engage the capsule upon retraction of the slide to jar the powder from the capsule into the slide opening 1|.

The mixing chamber 84 is defined by the bore in the body and the partition 15. This chamber e may be similar to that of the preferred embodiment or may be as illustrated. The chamber, as illustrated in Figs. 13 and 15, differs from the preferred embodiment only in that the tube is pressed into the end so that it may be more readily removed for discarding or sterilizing, and a few minor details are changed in an attempt to get more thorough mixture of air and powder. For instance, the only primary air opening 86 is at the bottom of the chamber so that all the primary air sweeps over the powder in the bottom of the chamber, and the entrance of the tube extends into the chamber so that the primary air will sweep more completely through the chamber. It will be realized that these changes are fully as applicable to my preferred embodiment as to this alternative form. A ridge 88 is also shown (Fig. 13) around the tube 85 in order that the tube may be more firmly grasped for insertion or withdrawal from the device and to prevent the users lips from stopping up the secondary air hole 36.

The operation of the last described device is in all respects similar to that of my preferred embodiment.

Still another form of my invention is illustrated in Fig. 16. In this embodiment, the mixing chamber 90 is formed in the inhaling tube 9|. The body portion 92 is a simple tube of circular cross section having a supply chamber 93 formed in one side. This may be similar to the supply chambers of the other embodiments. A push button slide member 94 is slidably disposed in one end of the body portion. This member may also be formed from a tube with one end closed by an end wall 95 preferably having air inlet holes 96 therein for reasons to be explained hereinafter. The powder carrying opening 91 is formed in the member 94 and has a slot 98 similar to the slot 12 in the previously described embodiment.

The tube 9| exteriorly of the body 92 has the same formation as previously described. However, in extension from the portion of tube surrounding the restriction 99 therein, the tube is formed to provide the mixing chamber 90. This is formed by decreasing the diameter of the tube so that the slide member 94 will slide over it. The end is closed by an end wall |09 which may be of hernispherical shape as shown. A hole |03 may preferably be provided in this end wall to allow the passage of the primary mixing air directly into the chamber 9|).` At the top of the chamber an opening |94 is provided through which the powder may drop, and a tongue |95 is struck upward from this opening similarly to that in previous embodiments.

The operation of `this device is the same as that of previous devices. The flow of the primary mixing air may be somewhat different, however, since it preferably comes in directly through the holes 96 in the push button and the hole |03 in the mixing chamber. The powder is picked up by this air, carried through the restriction 99 then mixed more thoroughly by the action of the secondary mixing air and carried into the passages as before.

Whereas in all the embodiments described, the slide member has been in a position to receive the powder from the supply chamber when the push button was retracted; still it will be apparent that this is not necessarily so, and that the device could be readily rearranged to provide that the push button be pushed in to load the lie-latter caseg'theV inhaler could be thrown away L d `replaced when thesupply of powder was exai'isted. While V,[have dscribed'my invention in several '^\einb`diments"thereof, it will be realizedv that it is`not`li-inited thereto, and that numerous and "extensive departures may be` made therefrom w'ithut "departing fi'om'the spirit or scope of invention. I claim:

An inhaler for 'therapeutic powder compris- H :ing abody, asupply chamber and a mixing cham- Fber -frmed in said body, a'slide operative be- "-tween said supply chamber and said mixing chamber to' carry a small 'amount of said powder 'from-saidsupply chamber to said mixing chamv'be'r, atube'connected into said mixing chamber andextending outwardly therefrom, and 4air pas- 'sages into said mixing Achamber for the induction i of'air.

2.-'An inhaler `for therapeutic vpowder compris- 1 ing'abody, a supply chamber and a mixing chamfv-'ber formedinv said body, slide means operative `betweensaid-'supply chamber and said mixing chamber to carry small amount of said powder from said supply chamber to said mixing chamber, tube means connected into said mixing cham- A ber adapted upon inhaling to conduct said powder into theoral or nasal passages, said slide means being adapted to'be snapped to jar said )gxwder-intc said Aslide means. Y

i 3'. An inhaler ier therapeutic powder comprising a body, a supply chamber and a mixing chaml"ber`fo`rmed in 'said body, slide means operative between saidsupply chamber and said mixing ."clianbe! tol carry asinall amount of lSaid powder from" said supplychamber to said mixing chamberjj tube'means connected into said mixing cham- '""beradapted 'upon inhaling to conduct said pow- ""de1""into' theoral or'nasal passages, said slide *"mean'sbeingadaptedto be snapped to jar said powder intrsaid slide means, vand air Ipassages formed beside said tube means to conduct air *into* 4said mixing chamber.

4; VAAndn'halerfor therapeutic powder comlpr'i'sing a' bdy, a supply chamber and ya mixing 'cha'mber formed said body, slide means operaf "tive between saidsupply chamber and said mix- 'ingchamber tecarry a small 'amunt of 'said powderirom-said supply chamber to said mixing lcliamber, tube means connected into-saidmixing "-'chamber-ada-ptedupon inhaling to conduct said powder into the oral or nasal passages,v primary mixingair passages `formed beside said tube to conduct air into* said mixing chamber and a secfondaryj mixingY air `opening in said tube outside nvof s'aidchamber. l f

fjiAn inhaler `I-for vtherapeutic powder comffprising abody, asupply chamber and a mixing i" `v`'cha-'rimer'formed i'n' said body, slide'means operahavingT A'the powder sealed in the chamber. vIn

1,; 8 i fftivf-'Utweeii-said suppiylgehamberfand saniy mixing-chamberl t'o-carry asmal-lamount f of said fpowrlerv vfrom saidl supply chamber tosaidmixing f chamber, 'tube' means connected -into saidmixing 55 chamber adaptedefor inhaling te conduct said 'powder -into the' oral or'- nasal passages, primary mixing airpassagesfrmed beside said tube to c'zonduct air intosaid mixingV chamber, a restrictio'n" iti-saidtube, a secondary-mixing air open- 105-ing said tube between'said'restriction and the I fopen-end of 'said tube -for- -further mixing of? said yair? Tand'-V powder.

6An` inhaler-fior therapeutic'powder comprising a'bo'dy", a` supply chamber formed inf-said @bodyf slide @means slidably disposed in saidbody beneathsaid-fs'upply chamber, an opening in said lslide means normally in 'position beneath -said ""supply chamber, -ax'nixing chamber in saidbody i4"beneath fsaid* slidemeans, Y said 'pening f being "-'ada`pted tobe'slid by lthe .slide means -Viromiits normal position to a" position over said mixing 'i chamber tocarry a small amount of--saidpowder jth'ereto,- a tuber extending from-said v mixing HAchamber through which'the powder *maybe in- 7. An inhaler*fortherapeutic powdercompris- 'ing a body, a supply chamber yformedin vsaid Abody adapted to receive a capsule of'said powder, a' slot'formed in said body beneath said supply chamber, slide `means lslidably-disposed in said slot, an'lpening in said slide `-means normally in "position beneath said supply chamber, aL spring engaging said body andsaidslide means urging said slidemeans toward-its normal position, stop i meansl yadapted to prevent movement ofV said slide means Yby said lspring beyond its normal position and tostop `said slide'suddenly upon its Hrelease from any- 'position other than its normal 'position to' jar said powder and cause it to fall 4o into said opening, a mixing chamber in said body beneath said slide means, said opening adapted to be vslid bysaidy slide means from its normal position to a position above said mixing chamber, Vfand tube means extending from said' mixing 4tnlhlirgber thrugh which said powder maybe in- 8. An inhaler for therapeuticpowder comprising a` body, a supply chamber formed insaid body, slide means slidably disposed in said body obeneatlr said supply chamber, an opening in said slide means normally in'v position Vbeneath said supply'chamber, a mixing chamber insaid body -`"beheathisaid slide means, said openingbeing adapted to be slid "by the slide means from its lnormalposition toa position over saidv mixing fchamberto carry a small amount of said powder "thereto,r a"'tube `extending from vsaid mixing 'y chamber through which the powderl may be in- "haled, and an air-'passage into said mixing cham- 6Ober tolallow.A entry of the air thereinto to mix with said powder. An inhaler for therapeutic powder `comprisrring a body,Y a supply chamber formed in'said "body, slide means slidablydisposed inv sai'db'ody beneath said supply chamber, an opening ir'i'said jslidenorrnallyfin position beneath said supply if -chamber, a mixing chamber'in said body beneath i Ysaidslide means; said openingbeing adapted to flee slidy bythe 'slide' means from its nrmarp'osi- Ation'A to a-pbsilti niA over saidV mixing' chambery to carry 4a smallamount of saidl powder thereto, a vr`ll`tube' extending? from' said An'fiixing chamber through which the powder'lmay be vinhaled, i primary Amixing'fair fpassageslfintcf *saidv` mixing lchamber,V` arestriction'` in said tube'andiisecodary mixing air passage into said tube between said restriction and the open end of said tube to provide further mixing of said air and said powder.

10. An inhaler for therapeutic powder comprising a body, a supply chamber and a mixing chamber formed in said body, slide means rotatably disposed on said body beneath said chambers, hollows formed in said slide means adapted to receive a small amount of powder from said supply chamber' and to carry it to said mixing chamber when said slide means is turned, and a tube extending from said mixing chamber through which said powder may be inhaled.

11. An inhaler for therapeutic powder comprising a cylindrical body, a supply chamber and a mixing chamber formed therein, slide means rotatably disposed beneath said chambers, hollows formed in said slide means adapted to c-arry said powder from said supply chamber to said mixing chamber, circumferential projections formed on said slide means each comprising a sloping rise portion and an abrupt drop off, spring means fastened to said body having a finger engaging said projection adapted to-in dex side slide means and to jar the powder from said supply chamber into said hollow upon reaching said drop off and a tube extending from said mixing chamber through which the powder may be inhaled.

12. An inhaler for a therapeutic powder cornprising a body, a supply chamber formed in said body of such size that a capsule of said powder may be smoothly inserted thereinto, a shoulder formed in said supply chamber to prevent insertion of said capsule beyond said shoulder, a

mixing chamber formed in said body, slide means rotatably disposed on said body beneath said chambers adapted to carry a certain amount of said powder from said supply chamber to said mixing chamber, a tube extending from said mixing chamber through which said powder may be inhaled.

13. An inhaler for a therapeutic powder comprising a body, a supply chamber and a mixing 'chamber formed in said body, slide means rotatably disposed on said body beneath said chambers adapted to carry said powder from said supply chamber to said mixing chamber in small increments, a tube extending into said mixing chamber through which said powder may be inhaled, primary mixing air passages extending into said mixing chamber, a restriction in said tube and secondary mixing air opening into said tube between said restriction and the open end of said tube to allow additional air to mix with said powder.

14. An inhaler for a therapeutic powder comprising a cylindrical body, a supply chamber and a mixing chamber formed in said body, a cylindrical pivot extending from the center of the bottom of said body, rotary slide means rotatably journalled on said pivot, hollows formed in said slide means adapted to carry said powder from said supply chamber to said mixing chamber in small increments, peripheral projections on said slide means each comprising a sloping rise portion and an abrupt drop oi, a spring washer surrounding said pivot adapted to urge said slide means into contact with said body, spring means mounted on said pivot means having a nger engaging said projections to index said slide means and to jar said powder from said supply chamber into said hollows upon snapping down from said drop 01T, and tube means extending from said mixing chamber through which the powder may be inhaled.

15. Diffusion means for a therapeutic powder inhaler comprising a mixing chamber formed in said inhaler having an opening for the entry of the powder and a tube opening, means in said inhaler adapted to close the opening for the entry of the powder after the powder is deposited in said chamber, a tube inserted into said tube opening, through which said powder may be inhaled, primary mixing air passages opening into said cham-ber cut into the walls of said tube opening, a restriction in said tube and a secondary mixing air opening in said tube between said restriction and open end of said tube.

16. Diiusion means for a therapeutic powder inhaler comprising a mixing chamber formed in said inhaler having a tube opening, a tube inserted into said tube opening and extending into said chamber through which said powder may be inhaled, primary mixing air passages extending into said chamber, a restriction in said tube, and a secondary mixing air opening in said tube between said restriction and the open end of said tube.

17. An inhaler for a therapeutic powder comprising a tubular body portion, a supply chamber formed in said body, slide means slidably disposed in one end of said body, tube means at the other end of said body, a mixing chamber formed in said tube means extending into said body, said slide means being disposed thereabout, said mixing chamber being formed with a powder inlet opening at the top, longitudinally displaced from said supply chamber, said slide Vmeans having a powder carrying opening normally disposed beneath said supply chamber and adapted to carry a small amount of powder from said supply chamber to a position directly above said powder inlet opening, spring means engaged between said slide means of said tube means to urge said slide means to its normal position.

18. An inhalator for a medicament comprising enclosure means enclosing a supply chamber and a mixing chamber, movable means movably associated with said enclosure means adapted to carry a small amount of said medicament from said supply chamber to said mixing chamber, said enclosure means being formed with outlet means from, and air inlet means into, said mixing chamber.

FRANK P. .PRIESTLY.

REFERENCES CITED The following references are of record in the Iile of this patent:

UNITED STATES PATENTS Number Name Date 576,437 Elliot Feb. 2, 1897 795,676 Ammen July 25, 1905 923,837 Hautsch June 8, 1909 2,092,888 MacCoul Sept. 14, 1937 2,200,076 Cooper May 7, 1940 2,259,759 Lufkin Oct. 21, 1941

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US576437 *Apr 1, 1896Feb 2, 1897 Insufflator
US795676 *Jan 16, 1905Jul 25, 1905Charles AmmenDispensing apparatus.
US923837 *Jun 7, 1907Jun 8, 1909Alfred P HautschCabinet.
US2092888 *Mar 21, 1936Sep 14, 1937Seth Thomas Clock CompanyBacklash eliminator
US2200076 *Dec 30, 1938May 7, 1940Rca CorpBank of switch keys
US2259759 *Jun 15, 1940Oct 21, 1941Owens Illinois Glass CoInhaler
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US2872923 *Mar 20, 1957Feb 10, 1959Birch And Gattone IncMeans for administering pressurized medicaments, gases, combinations thereof and liquids into body cavities
US4005711 *Jan 13, 1975Feb 1, 1977Syntex Puerto Rico, Inc.Inhalation device
US4014336 *Nov 20, 1975Mar 29, 1977Syntex Puerto Rico, Inc.Inhalation device
US4046146 *Aug 21, 1975Sep 6, 1977Schering AktiengesellschaftApparatus for the inhalation of medicinal agents
US4047525 *Jan 13, 1976Sep 13, 1977Schering AktiengesellschaftInhalator for agglomeratable pulverulent solids
US4064878 *Oct 26, 1976Dec 27, 1977Syntex Puerto Rico, Inc.Inhalation device
US4192309 *Sep 5, 1978Mar 11, 1980Syntex Puerto Rico, Inc.Inhalation device with capsule opener
US4227522 *Sep 5, 1978Oct 14, 1980Syntex Puerto Rico, Inc.Inhalation device
US4240418 *Feb 28, 1979Dec 23, 1980Schering AktiengesellschaftApparatus for the inhalation of medicinal agents
US4249526 *Apr 12, 1979Feb 10, 1981Fisons LimitedInhalation device
US4274403 *Aug 29, 1979Jun 23, 1981Struve Roger LInhaler
US4307734 *Jun 23, 1980Dec 29, 1981B & B Inventors & Marketers, Inc.Snuff dispenser
US4524769 *Jun 17, 1982Jun 25, 1985Aktiebolaget DracoDosage inhalator
US4570630 *Jun 18, 1984Feb 18, 1986Miles Laboratories, Inc.Medicament inhalation device
US4805811 *Mar 30, 1988Feb 21, 1989Aktiebolaget DracoDosage device
US4860740 *Feb 10, 1987Aug 29, 1989Riker Laboratories, Inc.Powder inhalation device
US5004021 *Sep 18, 1989Apr 2, 1991Institut Gidrodinamiki Imeni M.A. Lavrentieva Sibirskogo Oldelenia Akademii Nauk S.S.S.R.Arrangement for conveying powder to the barrel of a gas detonation apparatus
US5046493 *Feb 16, 1988Sep 10, 1991James KropkowskiNasal dispenser
US5113855 *Feb 14, 1990May 19, 1992Newhouse Michael TPowder inhaler
US5161524 *Aug 2, 1991Nov 10, 1992Glaxo Inc.Dosage inhalator with air flow velocity regulating means
US5176132 *Sep 12, 1991Jan 5, 1993Fisons PlcMedicament inhalation device and formulation
US5239992 *Jun 1, 1992Aug 31, 1993Societe Francaise D'aerosols Et De BouchageLoose powder inhaler with inhalation-actuated dosing piston
US5239993 *Aug 26, 1992Aug 31, 1993Glaxo Inc.Dosage inhalator providing optimized compound inhalation trajectory
US5331953 *Mar 2, 1990Jul 26, 1994Aktiebolaget DracoDevice in connection with an inhaler
US5347999 *Aug 13, 1991Sep 20, 1994Boehringer Ingelheim KgInhalation device free from propellant gas having brush abrading powder from tablet
US5437270 *Jan 6, 1993Aug 1, 1995Innovata Biomed LimitedPowder inhaler having a multi-positioned metering cup
US5437271 *Mar 31, 1994Aug 1, 1995Minnesota Mining And Manufacturing CompanyDeagglomerators for dry powder inhalers
US5447151 *Oct 4, 1991Sep 5, 1995ValoisPowder inhaler with suction actuated locking means
US5469843 *Nov 6, 1992Nov 28, 1995Minnesota Mining And Manufacturing CompanyInhalation device
US5507281 *Aug 20, 1992Apr 16, 1996Boehringer Ingelheim KgDevice for initiating a mechanical switching operation in synchronism with the breathing
US5538999 *May 23, 1995Jul 23, 1996Fisons PlcMedicament inhalation device and formulation
US5542411 *Jun 28, 1994Aug 6, 1996Novo Nordisk A/SManually operated dispenser for dispensing a predetermined amount of powdered substance
US5568884 *Jan 12, 1994Oct 29, 1996Valois S.A.Portable device for projecting measured quantities of a fluid substance by means of a puff of compressed air
US5575280 *Oct 25, 1994Nov 19, 1996Boehringer Ingelheim KgPowder inhalation device having nozzle to empty dosing chamber
US5612053 *Apr 7, 1995Mar 18, 1997Edward Mendell Co., Inc.Polysaccharide gum carrier
US5617845 *May 3, 1994Apr 8, 1997Boehringer Ingelheim KgInhalation device free from propellent gas
US5628307 *Jan 11, 1996May 13, 1997Fisons PlcMedicament inhalation device and formulation
US5657748 *Feb 3, 1995Aug 19, 1997Innovata Biomed LimitedPowder inhaler with frusto-conical metering surface having dose indentations
US5673685 *Nov 23, 1994Oct 7, 1997GGU Gesellschaft Fur Gesundheit und UmweltforschungDevice for generating inhalable active substance particles
US5738865 *Dec 30, 1996Apr 14, 1998Edward Mendell Co., Inc.Controlled release insufflation carrier for medicaments
US5778873 *Feb 18, 1993Jul 14, 1998Innovata Biomed LimitedMetering device for use in transferring a desired volumetric dose of a flowable substance from a storage container
US5840279 *Jun 21, 1996Nov 24, 1998Asta Medica AktiengesellschaftPharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments
US5857457 *May 10, 1995Jan 12, 1999Orion-Yhtyma OyPowder inhaler with remnant mover and chamber
US5924417 *Aug 25, 1997Jul 20, 1999Innovata Biomed LimitedMetering device for use in transferring a desired volumetric dose of a flowable substance from a storage container
US5976436 *Mar 20, 1997Nov 2, 1999Fisons PlcProcess for production of medicament formulations
US5996577 *Aug 9, 1996Dec 7, 1999Unisia Jecs CorporationMedicine administering apparatus
US6065471 *Sep 13, 1995May 23, 2000Laboratoire Glaxo WellcomeInhalation device
US6071498 *Jul 10, 1998Jun 6, 2000Asta Medica AktiengesellschaftInhaler for powdered medicaments
US6116239 *Aug 3, 1998Sep 12, 2000Art SlutskyInhalation device
US6220243Feb 1, 2000Apr 24, 2001Laboratoire Glaxo WellcomeInhalation device
US6234169Aug 14, 1998May 22, 2001Arthur SlutskyInhaler
US6332461 *Oct 21, 1998Dec 25, 2001Orion-Yhtyma OyPowder inhaler
US6387394Jul 26, 1999May 14, 2002Penwest Pharmaceuticals Co.Controlled release insufflation carrier for medicaments
US6484718 *Oct 25, 2000Nov 26, 2002Laboratoire Glaxo WellcomeInhalation device
US6575160Sep 7, 2000Jun 10, 2003Art SlutskyInhalation device
US6606992May 30, 2000Aug 19, 2003Nektar TherapeuticsSystems and methods for aerosolizing pharmaceutical formulations
US6681768Jun 21, 2002Jan 27, 2004Sofotec Gmbh & Co. KgPowder formulation disintegrating system and method for dry powder inhalers
US6926003 *Dec 7, 2000Aug 9, 2005Orion CorporationMultidose powder inhaler
US7107988Jan 28, 2005Sep 19, 2006Chiesi Farmaceutici S.P.A.Powder inhaler
US7172766Jan 14, 2002Feb 6, 2007Penwest Pharmaceuticals CompanyDry powder inhalation formulations which are capable of providing a slow, continuous release of drug while also being biodegradable or expellable from the pulmonary or nasal tract; bioavailability
US7185651May 14, 2003Mar 6, 2007Nektar TherapeuticsFlow regulator for aerosol drug delivery and methods
US7207330Jun 5, 2000Apr 24, 2007Innovata Biomed LimitedDelivery system
US7219665Sep 4, 2000May 22, 2007Innovata Biomed LimitedDelivery device
US7258118Jan 22, 2003Aug 21, 2007Sofotec Gmbh & Co, KgPharmaceutical powder cartridge, and inhaler equipped with same
US7461653 *Oct 13, 2003Dec 9, 2008Roberto OlivaSingle dose inhaler
US7464704Nov 22, 2002Dec 16, 2008Innovata Biomed LimitedMedicament delivery assembly
US7571723Mar 1, 2007Aug 11, 2009Innovata Biomed LimitedDelivery device
US7571724Mar 1, 2007Aug 11, 2009Innovata Biomed LimitedDelivery device
US7703620Apr 14, 2004Apr 27, 2010Glaxo Group LimitedChain linked capsules
US7713518Nov 18, 2003May 11, 2010Glaxo Group LimitedCapsule for a powder medicament
US7854226Apr 20, 2006Dec 21, 2010Chiesi Farmaceutici S.P.A.Powder inhaler
US7954492Nov 9, 2005Jun 7, 2011Almirall, S.A.Pharmaceutical powder cartridge, and inhaler equipped with same
US8051851Jul 18, 2005Nov 8, 2011Sofotec Gmbh & Co. KgInhaler for the administration of powdered pharmaceuticals, and a powder cartridge system for use with this inhaler
US8066002Dec 19, 2005Nov 29, 2011Glaxo Group LimitedManifold for use in medicament dispenser
US8205614Aug 10, 2009Jun 26, 2012Innovata Biomed LimitedDelivery device
US8357696Jan 28, 2010Jan 22, 2013Mpex Pharmaceuticals, Inc.Aerosolized fluoroquinolones and uses thereof
US8375940May 25, 2007Feb 19, 2013Almirall, S.A.Storage system for powdered pharmaceuticals and inhaler equipped with this system
US8408200Oct 7, 1999Apr 2, 2013Novartis AgFor delivering an active agent formulation to the lung of a human
US8495998Jun 17, 2009Jul 30, 2013British American Tobacco (Investments) LimitedInhaler
US8511302Apr 22, 2005Aug 20, 2013Innovata Biomed LimitedDose counter mechanisms for medicament delivery devices
US8524734Oct 22, 2009Sep 3, 2013Mpex Pharmaceuticals, Inc.Aerosolized fluoroquinolones and uses thereof
US8524735Oct 22, 2009Sep 3, 2013Mpex Pharmaceuticals, Inc.Aerosolized fluoroquinolones and uses thereof
US8534281Dec 11, 2006Sep 17, 2013Glaxo Group LimitedManifold for use in medicament dispenser
US8546423Oct 22, 2009Oct 1, 2013Mpex Pharmaceuticals, Inc.Aerosolized fluoroquinolones and uses thereof
US8550070 *Jun 20, 2002Oct 8, 2013Orion CorporationPowder inhaler
US8561609Dec 7, 2011Oct 22, 2013Respira Therapeutics, Inc.Dry powder inhaler
US8567394Dec 21, 2007Oct 29, 2013Almirall, S.A.Inhalation device for drugs in powder form
US8590531Dec 19, 2005Nov 26, 2013Glaxo Group LimitedManifold for use in medicament dispenser
US8629139Oct 6, 2009Jan 14, 2014Mpex Pharmaceuticals, Inc.Topical use of Levofloxacin for reducing lung inflammation
US8651104May 11, 2012Feb 18, 2014Respira Therapeutics, Inc.Bead-containing dry powder inhaler
US8668928Mar 26, 2010Mar 11, 2014Glaxo Group LimitedCapsule
US20100065048 *Feb 7, 2007Mar 18, 2010Jagotec AgDry powder inhaler devices
CN100584402CJan 3, 2003Jan 27, 2010Meda制药有限及两合公司Humidity-tight cartridge for a powder inhaler
DE3535561A1 *Oct 4, 1985May 22, 1986Orion Yhtymae OyVorrichtung zur dosierten abgabe einer medizinischen substanz
EP0069715A1 *Jun 10, 1982Jan 12, 1983Aktiebolaget DracoPowder inhalator
EP0079478A1 *Oct 21, 1982May 25, 1983Miles Laboratories, Inc.Medicament inhalation device
EP0407028A2 *May 29, 1990Jan 9, 1991FISONS plcMedicament inhalation device and formulation
EP0488609A1 *Nov 25, 1991Jun 3, 1992Ciba-Geigy AgPowder inhaler
EP0516510A1 *May 21, 1992Dec 2, 1992S O F A BPowder inhaler
EP0518087A1 *May 20, 1992Dec 16, 1992Miat S.P.A.Multi-dose insufflator for medicaments in powder form
EP0546996A2 *Dec 1, 1992Jun 16, 1993Sandoz Ltd.An inhaler
EP0549605A1 *Aug 22, 1991Jul 7, 1993Boehringer Ingelheim IntInhalator without propeller gas with foreign air stream.
EP0611577A1 *Nov 11, 1993Aug 24, 1994Bayer AgPowder inhalator
EP0759306A2 *Aug 9, 1996Feb 26, 1997Unisia Jecs CorporationMedicine administering apparatus
EP0928618A1Feb 18, 1993Jul 14, 1999Innovata Biomed LimitedPowder inhaler
EP1153626A1 *Aug 9, 1996Nov 14, 2001Dott Limited CompanyMedicine administering apparatus
EP1386630A1Jul 31, 2002Feb 4, 2004CHIESI FARMACEUTICI S.p.A.Powder inhaler
EP1616592A1Jul 12, 2005Jan 18, 2006Sofotec GmbH & Co. KGInhaler for the administration of powdered pharmaceuticals, and a powder cartridge for use with this inhaler
EP1658872A2Jul 31, 2002May 24, 2006CHIESI FARMACEUTICI S.p.A.Powder inhaler
EP1930041A2Nov 18, 2003Jun 11, 2008Glaxo Group LimitedCapsule for a powder medicament
EP1941868A2Feb 26, 2001Jul 9, 2008PharmaKodex LimitedImprovements in or relating to the delivery of oral drugs
EP2594272A2May 18, 2006May 22, 2013Mpex Pharmaceuticals, Inc.Aerosolized fluoroquinolones and uses thereof
WO1982001470A1 *Oct 28, 1981May 13, 1982Riker Laboratories IncPowder inhalation device
WO1992009322A1 *Nov 7, 1991May 30, 1992Boehringer Ingelheim IntInhalation device
WO1992011051A1 *Dec 17, 1991Jul 9, 1992Minnesota Mining & MfgClosure system for inhalers
WO1993003782A1 *Aug 14, 1992Feb 16, 1993Bon F DelInhaler
WO1993003783A1 *Aug 20, 1992Mar 4, 1993Boehringer Ingelheim IntDevice for triggering a mechanical switching process in synchronicity with breathing
WO1994004210A1 *Aug 4, 1993Mar 3, 1994Rix Earl EvansDosage inhalator providing optimized compound inhalation trajectory
WO1994005357A1 *Aug 30, 1993Mar 17, 1994Sven MaanssonDrug delivery system
WO1994005359A1 *Sep 7, 1993Mar 17, 1994Clive Graham AngelMedicament dispensing device
WO1994011044A2Nov 8, 1993May 26, 1994Minnesota Mining & MfgPowder inhaler
WO1995031237A1 *May 10, 1995Nov 23, 1995Jukka HyppoelaePowder inhaler
WO1996008284A2 *Sep 13, 1995Mar 21, 1996Glaxo Wellcome Lab SaInhalation device
WO1996008303A1 *Sep 11, 1995Mar 21, 1996Satoru KadowakiDeodorizing filter
WO1998026827A1Dec 17, 1997Jun 25, 1998Philip BraithwaitePowder inhaler
WO1999007426A1 *Aug 4, 1998Feb 18, 1999Slutsky ArtInhalation device
WO2000009188A1Aug 12, 1999Feb 24, 2000Bulbrook LeeInhaler
WO2002102444A1 *Jun 20, 2002Dec 27, 2002Orion CorpPowder inhaler
WO2003061742A2 *Jan 3, 2003Jul 31, 2003Sofotec Gmbh & Co KgHumidity-tight cartridge for a powder inhaler
WO2004012801A1Jul 30, 2003Feb 12, 2004Chiesi Farma SpaPowder inhaler
Classifications
U.S. Classification128/203.15, 222/361
International ClassificationA61M15/00, A61M15/06
Cooperative ClassificationA61M15/06, A61M15/0065, A61M2202/064
European ClassificationA61M15/00D