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Publication numberUS2612163 A
Publication typeGrant
Publication dateSep 30, 1952
Filing dateOct 9, 1950
Priority dateOct 9, 1950
Publication numberUS 2612163 A, US 2612163A, US-A-2612163, US2612163 A, US2612163A
InventorsWilson Y Norman
Original AssigneeWilson Y Norman
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Container for hypodermic preparations
US 2612163 A
Abstract  available in
Previous page
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Claims  available in
Description  (OCR text may contain errors)

Sept. 30, 1952 w. Y. NORMAN CONTAINER FOR HYPODERMIC PREPARATIONS Filed Oct. 9, 1950 %/F//2////// 7//// b 2 z INVENTOR.

VW/ O/I Y JVor/v cm rrom Ey Patented Sept. 30, 1952 UNIT EED STATESS PATENT em UGN'l-AINER FOR 'HYPGDERM'IG PREPARATIONS Wilson 3!. Norman, Amarillo, Tex.

'iappiicationbetober 9, 1950, Serial N0. 189,222

2 Claims. 1

This invention relates to the packaging of medicinal preparations intended forhypodermic administration and more especially to an improved receptacle or container therefor.

Certain medicines intended for "hypodermic .injection cannot be kept in solution becauseof undesirable changes which take place unless the solution is kept properly refrigerated, and even then it is not desirable "that they be kept for too long a period. Penicillin-is'anexample. This is marketed in powder or crystal form in 'asealed container, with a separate container of the sterile liquid in which it is to "be dissolved'and the solution is then effected at the time the medicine is to be used.

An object of the present-invention is to provide a two purpose vial or container 'which'will make it more convenient for doctors making house calls, to easily and quickly prepare the solution for use, without having to handle separate'containers as is nowrequired.

Another object of theinvention is to provide a novel two chamber vial containing the medicinal substance and the solvent therefor, separated by a septum through which a hypodermic needle may be thrust easily, whereby the solvent and the medicine may be picked up and mixed without removing the needle from the vial.

Other objects and advantages of the invention will become apparent as the description of the same proceeds and the invention will be best understood from a consideration of the following detailed description taken in connection with the accompanying drawing forming a part of the specification, with the understanding, however, that the invention is not to be limited to the exact details of construction shown and described since obvious modifications will occur to a person skilled in the art.

In the drawing:

Figure 1 is a longitudinal section through a two chamber vial constructed in accordance with one embodiment of the invention.

Figure 2 is a transverse section taken on the line 2-2 of Figure 1.

Figure 3 illustrates a stage of the method of preparing and withdrawing the solution into a hypodermic syringe.

Figure 4 illustrates another form in which the vial may be made.

Referring now more particularly to the drawing the numeral generally designates one form of vial constructed in accordance with the present invention. This comprises a glass body [2 in the form of a short cylinder having a bottom [4 2 and a mouthopening .16, having the same diameter as'the insideof thevialwhichis straight, or of constant diameter through its length.

,Around the outside of the vial, at the month end, a flange or bead, I8 is formed to facilitate thetsecurement of a cap 20 .thereover as-shown, such cap being of thin easily torn metal, or other suitable material, whereby it may be readily removed.

The numerals 2i and 22 designate i-respective- 'lya stopper disk'and a septumwhich are of substantial' thickness and are formed preferably of rubber or'other suitable material, which may :be easily pierced by the needle of a hypodermic syringe.

In the lower end of the vial is a :glass liner cylinder '23 and upon this'is positioned the septum .22 which is tightly press fitted into the vial, thus forming the chamber 24, :in which is placed the medicine 25.

The septum 22 has its periphery insufliciently tight contact with the wall of the vial to prevent leakage into the chamber 24, of the solvent liquid in the upper chamber 26, which has for its side wall a glass liner cylinder 21 which, like the liner 23, fits tightly in the vial. The bottom of the liner 21 presses against the top of the septum 22 and its top edge is spaced from the top of the vial a distance equal to the thickness of the stopper disk 2|.

The liquid, designated 28, may be any desired solvent for the medicinal powder 25. In the case of penicillin it would be sterile water. This is kept tightly in the chamber 26 by the rubber stopper 21 which, like the stopper 22, is forced tightly into the mouth of the vial and rests against the top edge of the liner 21.

The cap 20, as shown, covers the stopper 2| and holds it against accidental removal.

While the form of the vial so far described is preferred, it may also be as shown in Figure 4, that is, without the glass liners 23 and 21. Here as shown the body is'designated I20: and it is divided into the two chambers 24a and 26a by the septum 220:. which is pressed tightly into the bottle, and the rubber disk stopper 2m which is pressed tightly into the mouth of the vial. This stopper is covered by the easily removablemetal cap 20a.

In the use of the vial according to the method forming a part of the present invention, the physician removes the metal cap 20 or 20a and thrusts the needle 29 of the hypodermic syringe 30 through the soft rubber stopper into the liquid chamber 26 or 26a. The liquid may then be extracted into the barrel of the syringe, after which the needle is thrust further in and through the septum 22 or 22a into the medicine carrying chamber 24 or 24a. The liquid may then be partially ejected to effect the solution of the medicine therein and the solution then drawn back into the syringe barrel and the needle then withdrawn.

Thus the making of the solution is accomplished and the solution is drawn into the syringe barrel without exposing either the liquid or the medicinal powder to the atmosphere; there is no handling of two separate containers or pouring off the liquid from one container, through the air, into the other, and there is no thrusting of the needle into one container and withdrawing it and thrusting it into, or through the stopper, of another container.

It is also pointed out that the vial does not have to be made of a specified diameter to fit into a syringe barrel as in the case of the packaging of some sterile solutions which are ejected directly from the vial or ampoule and neither is it necessary for the physician to carry a special type of syringe made to accommodate such special vials which are plugged or closed at both ends by removable, or easily penetrable, stoppers.

As previously stated, the present invention may be carried out by the use of either type of vial, but the type first described is preferred, because the use of the liners against which the stopper and septum bear, prevents any possibility of either slipping in forcing the needle therethrough.

While in describing the invention the lower chamber 24 or 24a has been set forth as containing the medicinal powder with the liquid in the top chamber, it is understood that they may be reversely placed if desired without departing from the invention.

I claim:

1. A receptacle for maintaining a medicinal 4 agent and solvent therefor separate and sterile until ready for use, comprising a vial having a solid bottom at one end and a mouth opening at its other end, the vial being internally cylindrical and of unvarying inside diameter, the diameter of the mouth being the same as the inside diameter of the vial, a moisture proof septum dividing the vial between its ends to form a lower chamber, a stopper disk fitting tightly into the mouth opening and spaced from the septum to form an upper chamber, said septum and disk being of a soft material for penetration by a hypodermic needle and having their peripheries tightly, frictionally engaging the vial wall, one of said chambers containing a medicinal agent and the other chamber containing a solvent therefor, and means separate and separable from the stopper and overlying the vial mouth for preventing accidental escape of the stopper. r

2. A receptacle of the character stated in claim 1, with a glass liner cylinder within the lower chamber against the wall thereof and between the septum and the solid bottom and a second glass liner cylinderin the upper chamber between and maintaining the septum and stopper separated.


REFERENCES CITED The following references are of record in the file of this patent:

UNITED STATES PATENTS a Number Name Date 683,994 Schirmer Oct. 8, 1901 1,943,120 Kabnick Jan. 9, 1934 1,960,858 Strauch May 29, 1934 1,967,439 Heineman July 24, 1934 2,404,316 Sack July 16, 1946 2,494,456 Still Jan. 10, 1950 2,559,231 Seemar July 3, 1951 Seemar Sept. 18, 1951

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US683994 *Jun 27, 1901Oct 8, 1901Gustav SchirmerMedicament-applicator.
US1943120 *May 21, 1930Jan 9, 1934Stuart KabnickHypodermic syringe
US1960858 *Jul 15, 1931May 29, 1934Burkart Strauch ClaussCombination of two incompatibles
US1967439 *Sep 26, 1927Jul 24, 1934Cook Lab IncMedicament package and process
US2404316 *Apr 4, 1941Jul 16, 1946Anni SackAmpulla syringe
US2494456 *Mar 18, 1946Jan 10, 1950Kathleen S StillContainer
US2559231 *Dec 13, 1949Jul 3, 1951Seemar George HPluri-compartment packaging and dispensing container for hypodermic injection ingredients
US2568029 *Feb 9, 1950Sep 18, 1951George H SeemarUnitary container for hypodermic injection ingredients
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US2655919 *Apr 17, 1951Oct 20, 1953Charles B GoodsteinHypodermic syringe and cartridge therefor
US3033203 *Feb 15, 1957May 8, 1962Baxter Laboratories IncMethod of preparing a solution
US3050061 *May 29, 1957Aug 21, 1962Baxter Laboratories IncParenteral solution equipment
US3351058 *Jul 12, 1965Nov 7, 1967Amco Capital CorpTwo compartment medical injector
US3918909 *Sep 20, 1972Nov 11, 1975Philips CorpApparatus for performing saturation analyses
US3921800 *Oct 26, 1973Nov 25, 1975Cementation Chemicals LimitedCapsule for use in fixing rock-bolts
US4657869 *May 18, 1984Apr 14, 1987E. I. Du Pont De Nemours And CompanySelf-contained device for carrying out specific binding assays
US6419414Apr 20, 2001Jul 16, 20023M Innovative Properties CompanyContainer for multiple-component compositions
US6543612May 21, 2001Apr 8, 20033M Innovative Properties CompanyContainer for compositions made of two or more components
US20130284680 *Dec 20, 2011Oct 31, 2013Ge Healthcare Uk LimitedFiltration device and method
U.S. Classification604/416, 206/219, 215/DIG.800, 206/222
International ClassificationB65D25/08
Cooperative ClassificationB65D25/08, Y10S215/08
European ClassificationB65D25/08