|Publication number||US2621145 A|
|Publication date||Dec 9, 1952|
|Filing date||Aug 17, 1949|
|Priority date||Aug 17, 1949|
|Publication number||US 2621145 A, US 2621145A, US-A-2621145, US2621145 A, US2621145A|
|Inventors||Sano Machteld E|
|Original Assignee||Sano Machteld E|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (8), Referenced by (123), Classifications (12)|
|External Links: USPTO, USPTO Assignment, Espacenet|
Dec. 9, 1952 M. E. sANo 2,621,145
BONE MAT COMPOSITIONS Filed Aug. 17, 1949 FGzl- TNESSES l INVENTOR.-
A TTORN E YS Patenied Dec. 9, 1952 UNITED STATES 'TENT OFFICE BONE MAT COMPSITIONS Machteld E. Sano, Philadelphia, Pa.
Application August 17, 1949, Serial No'. 110,743
Claims. (Cl. 167-84) This invention relates to the eld of bone surgery and is directed particularly to the provision of a flexible strip comprising particles of bone held together by a fibrin network and sufficiently flexible to permitthe formation of a rolled strip.
In the eld of bone surgery it is frequently required to replace sections of bone or fragments thereof. The physiological replacement of large pieces of bone or fragments in the human or animal body requires time and in certain unfavorable instances will not take place. In order to bridge the gap and to thus facilitate the process of regrowth, the surgeon introduces a piece of bone which he may obtain from a bone bank or which he may remove from a healthy bone of the patient. Specially treated animal bones have also been used in this way. In any of these three instances the process is time consuming. One of the objections to the use of bone grafts of this kind is the accurate cutting and fitting which is time consuming. A further diiiiculty in the methods heretofore employed has been in readily obtaining bone grafts of the desired shapes and lengths.
The purpose of the present invention ls to provide a composition of bone particles which will promote the assimilation of the bone by the host and which can be readily obtained and which will be easy to use. To further this object, the present invention provides a flexible mat comprising, in combination, a multiplicity of bone particles enmeshed in a brin network, the entire composition being adapted for use in certain fields of bone surgery in place of the bone grafts heretofore used.
A preferred process for preparing the composition which is the subject of the present invention is described hereinafter in detail, reference being had to the accompanying drawings in which Fig. I1 is a plan view of a portion of iiexible strip comprising bone particles enmeshed in a brin network on a cellophane carrier;
Fig. 2 is a cross section taken through the lines II-II of Fig. 1;
Fig. 3 is a perspective view showing the flexible strip of Fig. 1 in roll form and;
Fig. 4 is a semi-schematic plan view greatly enlarged of a portion of a flexible strip comprising bone dust particles enmeshed in a fibrin network.
In the drawings a multiplicity of bone particles I are shown enmeshed in a fibrin network 2. The bone mat thus formed is supported by a carrier strip 3 comprising a thin exible plas- .tic material such as cellophane. In preparing the bone particles l, pieces of bone, including the cortex, are obtained under sterile conditions from animals but preferably from humans, and these bones are ground by means of a bone grinder. The sizes of` bone particles may vary from bone dust where the particle size is of the order of T16 mm. to particles which may be 4 mm. in diameter or more. It is preferable, however, to providebone particles of 'substantially the same size for a given bone mat composition. I have found it advantageous to provide bone particles of the following sizes:
-1% mm., or bone dust 1-'2 mm. in diameter 2-'4 jmm. in diameter This provides a selectionin making up a given quantity of the bone mat composition of the present invention;
A sterile flexible strip made of a plastic material such as cellophane or the like, is placed in a sterile container or on a sterile' glass plate. This strip for convenience may be about 5 cm. wide. The previously prepared bone particles are then sprinkled on the sterile strip in a thin layer leaving an unsprinkled edge free of bone particles from 2-3 mm. from each side and end of the flexible carrier strip. The container or glass plate is then Vshaken gently to provide an even layer. Citrated or heparinized plasma, either human or animal, is then sprayed or drippedl on the thin layer of bone particles in sufficient quantity to wet the entire surface. Thisvwill vary according to the size of the bone particles but will be approximately l/2 cc. of plasma per 2 square cm. of bone particle layer. The plasma should be sterile and not over 24 hours should elapse between the time of its collection and the time of its use.
Following the application of plasma, thromboplastin containing 500 units per cc. or more is sprayed over the bone and plasma layer, it being sufficient to use 1/4 cc. of thromboplastin per 2 square cm. of surface. The treated layer with its mixture of plasma and thromboplastin is next gently pressed with the fleshy part of the foreiinger or a small rubber cushion and the edges of the strip are gently patted inwards. The sterile container or glass plate is gently tilted for about 5 minutes to let the excess iiuid drain and the drained layer is then gently pressed as in the previous pressing step. The bone mat thus formed supported by the cello- 3 phane carrier strip may now be rolled upon itself, placed in a sterile tin container and sealed air-tight or it may be stored in a glass container and sealed air-tight.
The procedure outlined above for preparing the bone mat composition of the present invention is applicable particularly in the case where human plasma is used. In the event that animal plasma is used, best results are obtained if the steps involving spraying with plasma and then with thromboplastin are repeated. It is also possible to form a thicker layer of bone mat by repeating the entire process a number of times and then building up a succession of layers.
The addition of the thromboplastin to the plasma, which contains brinogen, results in the formation of a brin network which enmeshesy the bone particles and holds them together thus forming a bone mat.
It will be apparent that the exible plastic carrier strip serves to support the bone. particle layer during the treatment with plasma and thromboplastin and permits rolling so that the strip canbe effectively stored. The bone mat comprising bone particles enmeshed in a brin network can be removed from the carrier strip by a roll-off operation as shown in Fig. 3 of the drawings.
The nal bone mat composition ofthe present invention may b e looked upon as the bone particle-brin network layer and it is possible to store this layer either flat or rolled. For convenience it is desirable to store the bone mat layer rolled and with the carrier strip. affixed. At the time of ultimate use the bone particle-nbrin mat is removed from the carrier strip.
In using the composition of the present invention in bone surgery, the surgeon merely unrolls the slightly humid bone mat and removes it from the plastic carrier strip. A strip of bonemat prepared with 1-2'mm.` bone(particles` which is 5 cm.
wide and V10 cm. long can be rolled withoutthe plastic carrier strip into a bone roll 5 cm. long and 11/2 to 2 om: in diameter whiehrmay be used in ways which will be apparent to the skilled surgeon.
In addition to being much easier to useand less time consuming, the bonematof the present invention encourages:v a morel rapid regrowth of bone bythe body as compared to the ratel of regrowth where the usualbone grarftpmethod is used.
In describing the present invention a specific preferred example has been given. However, it will be understood thatv various modications may be employed withoutdepartingfrom the spirit of the present invention as set forth inthe appended claims. Likewise if prepared on a large scale certain modications will suggest themselves as being applicable to mass production methods.
Having thus described my invention, I claim:
1. A bone roll for use in bone surgery in promoting regrowth of bone comprising a rolled flexible strip consisting of a multiplicity of unboiled particles of ground whole bone enmeshed in a fibrin network and held together thereby.
2. A iiexible strip for use in bone surgery in promoting regrowth of bone comprising a multiplicity of unboiled particles of ground whole bone enmeshed in fibrin in the form of a bone particlebrin network and a thin, flexible carrier strip support for said network.
3. The invention of claim 2 further characterized by the fact that the carrier strip consists of a sterile strip of cellophane.
4. A bone roll for use in bone surgery in promoting regrowth of bone comprising a rolled flexible strip consisting of a multiplicity of unboiled particles of ground whole bone held together by a fibrin network and supported on a thin, ilexible carrier strip.
5. A flexible mat which can be rolled into any desired length, thickness and shape for use in bone surgery in promoting. regrowth` of bone comprising a strip consisting of a multiplicity of unboiled particles ofy ground whole boneenmeshed in a fibrin network and held together thereby.
MACHTELD E. SANO;
The following references arel of record in the file ofthis patent:
UNITED=STATES PA'IEN'IS Number Name Date 2,241,868. Reimann May 13, 1941 2,398,077 Smith Apr. 9, 1946 2,433,299 Seegers Dec. 23, 1947 2,485,791 Tucker Oct. 25, 1949 2,492,458 Bering. Dec. 27, 1949 2,517,772 Doub Aug. 8, 1950 FOREIGN PATENTS Number Country` Date 18,601 Great Britain -.A. D. 1897 474,093 Germany Mar. 26, 1929 OTHER REFERENCES Drug and Cosmetic Industry, May 1937, page 727, Stimulating Bone Growth.
Blaine, Experimental Observations Annals of Surgery, January 1947, pagesf102 to 106, 108 to 114, especially at page 108.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2241868 *||Nov 2, 1938||May 13, 1941||Hall Lab Inc||Method of processing blood|
|US2398077 *||Apr 29, 1940||Apr 9, 1946||Parke Davis & Co||Blood coagulating product and method of obtaining same|
|US2433299 *||Jan 22, 1944||Dec 23, 1947||Parke Davis & Co||Blood coagulant and method of preserving same|
|US2485791 *||Jun 10, 1948||Oct 25, 1949||Tucker Jr Eli Jordan||Bone bank and method of preserving bones for transplantation|
|US2492458 *||Dec 8, 1944||Dec 27, 1949||Jr Edgar A Bering||Fibrin foam|
|US2517772 *||May 11, 1945||Aug 8, 1950||Parke Davis & Co||Neutralized oxidized cellulose products|
|DE474093C *||Jul 30, 1927||Mar 26, 1929||Heyl & Co||Verfahren zur Herstellung blutstillender und wundheilender Verbaende und Pflaster|
|GB189718601A *||Title not available|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US2690198 *||Jan 18, 1950||Sep 28, 1954||Anderson Roger||Saw tooth cutter for dividing bone for orthopedic operations|
|US2721555 *||Dec 3, 1952||Oct 25, 1955||Jenney John A||Dermatome|
|US3022783 *||Aug 10, 1960||Feb 27, 1962||Method of preserving tissue such|
|US3126884 *||Mar 30, 1961||Mar 31, 1964||Method of preserving animal tissue|
|US4186448 *||Nov 21, 1977||Feb 5, 1980||Brekke John H||Device and method for treating and healing a newly created bone void|
|US4430760 *||Dec 18, 1981||Feb 14, 1984||Collagen Corporation||Nonstress-bearing implantable bone prosthesis|
|US4553272 *||Feb 26, 1981||Nov 19, 1985||University Of Pittsburgh||Regeneration of living tissues by growth of isolated cells in porous implant and product thereof|
|US4743229 *||Sep 29, 1986||May 10, 1988||Collagen Corporation||Collagen/mineral mixing device and method|
|US4789663 *||Jul 5, 1985||Dec 6, 1988||Collagen Corporation||Methods of bone repair using collagen|
|US5000746 *||Aug 11, 1988||Mar 19, 1991||Friedrichsfeld Gmbh Keramik- Und Kunststoffwerke||Wound covering having connected discrete elements|
|US5356630 *||May 7, 1993||Oct 18, 1994||Massachusetts Institute Of Technology||Delivery system for controlled release of bioactive factors|
|US5403317 *||Oct 12, 1993||Apr 4, 1995||Bonutti; Peter M.||Apparatus and method for tissue removal|
|US5545409 *||Apr 5, 1994||Aug 13, 1996||Massachusetts Institute Of Technology||Delivery system for controlled release of bioactive factors|
|US5577517 *||Dec 9, 1994||Nov 26, 1996||Bonutti; Peter M.||Method of grafting human tissue particles|
|US5629009 *||Aug 7, 1996||May 13, 1997||Massachusetts Institute Of Technology||Delivery system for controlled release of bioactive factors|
|US5694951 *||Aug 9, 1996||Dec 9, 1997||Bonutti; Peter M.||Method for tissue removal and transplantation|
|US5769897 *||Feb 28, 1994||Jun 23, 1998||Haerle; Anton||Synthetic bone|
|US5935131 *||Apr 11, 1997||Aug 10, 1999||Bonutti; Peter M.||Apparatus and method for tissue removal|
|US5935594 *||Apr 6, 1998||Aug 10, 1999||Thm Biomedical, Inc.||Process and device for treating and healing a tissue deficiency|
|US5944721 *||Dec 8, 1997||Aug 31, 1999||Huebner; Randall J.||Method for repairing fractured bone|
|US5981825 *||May 13, 1994||Nov 9, 1999||Thm Biomedical, Inc.||Device and methods for in vivo culturing of diverse tissue cells|
|US6030635 *||Feb 27, 1998||Feb 29, 2000||Musculoskeletal Transplant Foundation||Malleable paste for filling bone defects|
|US6045555 *||Dec 10, 1997||Apr 4, 2000||Osteonics Corp.||Bone graft delivery system and method|
|US6120539 *||May 1, 1997||Sep 19, 2000||C. R. Bard Inc.||Prosthetic repair fabric|
|US6142998 *||Jan 3, 2000||Nov 7, 2000||Howmedica Osteonics Corp.||Bone graft delivery surgical instruments|
|US6174313||Jun 1, 1999||Jan 16, 2001||Peter M. Bonutti||Apparatus and method for tissue removal|
|US6258124||May 10, 1999||Jul 10, 2001||C. R. Bard, Inc.||Prosthetic repair fabric|
|US6264701||Dec 7, 1998||Jul 24, 2001||Kensey Nash Corporation||Device and methods for in vivo culturing of diverse tissue cells|
|US6270530||Jun 9, 2000||Aug 7, 2001||C.R. Bard, Inc.||Prosthetic repair fabric|
|US6309395||Apr 25, 2000||Oct 30, 2001||Howmedica Osteonics Corp.||Bone graft delivery surgical instruments|
|US6326018||Oct 7, 1999||Dec 4, 2001||Musculoskeletal Transplant Foundation||Flexible sheet of demineralized bone|
|US6437018||Feb 29, 2000||Aug 20, 2002||Musculoskeletal Transplant Foundation||Malleable paste with high molecular weight buffered carrier for filling bone defects|
|US6468289||Jan 14, 2000||Oct 22, 2002||Peter M. Bonutti||Apparatus and method for tissue removal|
|US6497650||Jul 28, 2000||Dec 24, 2002||C. R. Bard, Inc.||Hernia prosthesis|
|US6543455||Jan 11, 2002||Apr 8, 2003||Peter M. Bonutti||Cell harvesting method|
|US6592531||Sep 3, 2002||Jul 15, 2003||Bonutti 2003 Trust-A||Surgical instrument positioning system|
|US6607534||Jan 29, 2002||Aug 19, 2003||Peter M. Bonutti||Tissue engagement method|
|US6630000||Nov 19, 1999||Oct 7, 2003||Bonutti 2003 Trust-A||Method of using body tissue|
|US6632247||Mar 22, 2001||Oct 14, 2003||Synthes (Usa)||Implants formed of coupled bone|
|US6638309 *||Jun 1, 2001||Oct 28, 2003||Bonutti 2003 Trust A||Method of using body tissue|
|US6652532||Dec 4, 2001||Nov 25, 2003||Bonutti 2003 Trust A||Tissue repair method|
|US6652595||Jan 9, 1998||Nov 25, 2003||Davol Inc.||Method of repairing inguinal hernias|
|US6702856||Dec 11, 2001||Mar 9, 2004||The Bonutti 2003 Trust A||Method of using Tissue|
|US6719803||Sep 3, 2002||Apr 13, 2004||Bonutti 2003 Trust-A||Method for forming and implanting a grafting material containing tissue|
|US6736853||Oct 19, 2001||May 18, 2004||The Bonutti 2003 Trust A||Method of using tissue cage|
|US6776800||Aug 13, 2001||Aug 17, 2004||Synthes (U.S.A.)||Implants formed with demineralized bone|
|US6776938||Feb 21, 2003||Aug 17, 2004||Bonutti 2003 Trust-A||Method for forming implant containing tissue|
|US6790213||Jan 7, 2002||Sep 14, 2004||C.R. Bard, Inc.||Implantable prosthesis|
|US6835198||Dec 5, 2001||Dec 28, 2004||The Bonutti 2003 Trust A||Apparatus and method for tissue removal|
|US6855169||Aug 13, 2001||Feb 15, 2005||Synthes (Usa)||Demineralized bone-derived implants|
|US6860904||Oct 24, 2002||Mar 1, 2005||Bonutti 2003 Trust-A||Method for tissue grafting|
|US6905517||Oct 24, 2002||Jun 14, 2005||Bonutti Ip, Llp||Tissue grafting material|
|US6986788||Apr 9, 2001||Jan 17, 2006||Synthes (U.S.A.)||Intervertebral allograft spacer|
|US6989029||Feb 21, 2003||Jan 24, 2006||Bonutti Ip, Llc||Tissue cage|
|US6990982||Mar 12, 2003||Jan 31, 2006||Bonutti Ip, Llc||Method for harvesting and processing cells from tissue fragments|
|US6998135||May 14, 2001||Feb 14, 2006||Musculoskeletal Transplant Foundation||Demineralized corticocancellous bone sheet|
|US7070557||Mar 4, 2004||Jul 4, 2006||Marctec, Llc||Tissue graft material and method of making|
|US7087087||Oct 14, 2003||Aug 8, 2006||Boyer Ii Michael L||Implants formed of coupled bone|
|US7115146||Mar 22, 2001||Oct 3, 2006||Boyer Ii Michael L||Multipiece implants formed of bone material|
|US7134437||Mar 22, 2002||Nov 14, 2006||Bonutti Ip, Llc||Method for utilizing human tissue|
|US7156804||Dec 2, 2002||Jan 2, 2007||Davol, Inc.||Hernia prosthesis|
|US7226482||Sep 1, 2004||Jun 5, 2007||Synthes (U.S.A.)||Multipiece allograft implant|
|US7232464||Aug 19, 2004||Jun 19, 2007||Synthes (Usa)||Intervertebral implant|
|US7235079||Nov 18, 2004||Jun 26, 2007||Acumed Llc||Composite bone fasteners|
|US7300465||Jun 10, 2005||Nov 27, 2007||Synthes (U.S.A.)||Intervertebral allograft spacer|
|US7404819||Sep 14, 2000||Jul 29, 2008||C.R. Bard, Inc.||Implantable prosthesis|
|US7462200||Nov 23, 2005||Dec 9, 2008||Marctec, Llc||Method for tissue grafting|
|US7601173||May 7, 2007||Oct 13, 2009||Synthes Usa, Llc||Multipiece allograft implant|
|US7608113||Nov 24, 2003||Oct 27, 2009||Synthes Usa, Llc||Demineralized bone implants|
|US7618456||May 22, 2007||Nov 17, 2009||Synthes Usa, Llc||Intervertebral implant|
|US7727283||Mar 4, 2004||Jun 1, 2010||P Tech, Llc.||Tissue stabilizing implant method|
|US7753963 *||Sep 8, 2008||Jul 13, 2010||Synthes Usa, Llc||Demineralized bone-derived implants|
|US7824420||May 26, 2004||Nov 2, 2010||C.R. Bard, Inc.||Implantable prosthesis|
|US7846207||Aug 8, 2005||Dec 7, 2010||Synthes Usa, Llc||Intervertebral implant|
|US7862616||Apr 29, 2009||Jan 4, 2011||Synthes Usa, Llc||Intervertebral implant|
|US7896880||Nov 15, 2001||Mar 1, 2011||P Tech, Llc||Apparatus and method for tissue removal|
|US8043377||Sep 2, 2006||Oct 25, 2011||Osprey Biomedical, Inc.||Implantable intervertebral fusion device|
|US8182545||Jul 10, 2008||May 22, 2012||C.R. Bard, Inc.||Implantable prosthesis|
|US8480757||Aug 28, 2006||Jul 9, 2013||Zimmer, Inc.||Implants and methods for repair, replacement and treatment of disease|
|US8497121||Mar 23, 2012||Jul 30, 2013||Zimmer Orthobiologics, Inc.||Method of obtaining viable small tissue particles and use for tissue repair|
|US8518433||Dec 15, 2011||Aug 27, 2013||Zimmer, Inc.||Method of treating an osteochondral defect|
|US8524268||Dec 15, 2011||Sep 3, 2013||Zimmer, Inc.||Cadaveric allogenic human juvenile cartilage implant|
|US8540774||Nov 5, 2008||Sep 24, 2013||DePuy Synthes Products, LLC||Low profile intervertebral implant|
|US8652507||Dec 22, 2010||Feb 18, 2014||Zimmer, Inc.||Juvenile cartilage composition|
|US8709085||Oct 28, 2011||Apr 29, 2014||DePuy Synthes Products, LLC||Intervertebral implant|
|US8715354||Oct 28, 2011||May 6, 2014||DePuy Synthes Products, LLC||Intervertebral implant|
|US8747439||Jul 10, 2006||Jun 10, 2014||P Tech, Llc||Method of using ultrasonic vibration to secure body tissue with fastening element|
|US8764831||Dec 15, 2010||Jul 1, 2014||DePuy Synthes Products, LLC||Intervertebral implant|
|US8765165||Aug 23, 2010||Jul 1, 2014||Zimmer, Inc.||Particulate cartilage system|
|US8784863||Dec 22, 2010||Jul 22, 2014||Zimmer, Inc.||Particulate cadaveric allogenic cartilage system|
|US8808329||Apr 3, 2012||Aug 19, 2014||Bonutti Skeletal Innovations Llc||Apparatus and method for securing a portion of a body|
|US8814902||Jul 31, 2006||Aug 26, 2014||Bonutti Skeletal Innovations Llc||Method of securing body tissue|
|US8834914||Dec 22, 2010||Sep 16, 2014||Zimmer, Inc.||Treatment methods using a particulate cadaveric allogenic juvenile cartilage particles|
|US8845687||Sep 17, 2013||Sep 30, 2014||Bonutti Skeletal Innovations Llc||Anchor for securing a suture|
|US8845699||Mar 6, 2012||Sep 30, 2014||Bonutti Skeletal Innovations Llc||Method of securing tissue|
|US9005295||Aug 27, 2012||Apr 14, 2015||DePuy Synthes Products, LLC||Low profile intervertebral implant|
|US9039775||Jun 7, 2013||May 26, 2015||DePuy Synthes Products, Inc.||Spinal fixation plates|
|US9072586||Oct 2, 2009||Jul 7, 2015||C.R. Bard, Inc.||Implantable prosthesis|
|US9138318||Dec 15, 2011||Sep 22, 2015||Zimmer, Inc.||Apparatus for forming an implant|
|US9192419||Nov 6, 2009||Nov 24, 2015||DePuy Synthes Products, Inc.||Zero-profile interbody spacer and coupled plate assembly|
|US9220604||Dec 21, 2011||Dec 29, 2015||DePuy Synthes Products, Inc.||Intervertebral implants, systems, and methods of use|
|US9241809||Feb 14, 2013||Jan 26, 2016||DePuy Synthes Products, Inc.||Intervertebral implants, systems, and methods of use|
|US9320549||Apr 30, 2015||Apr 26, 2016||DePuy Synthes Products, Inc.||Spinal fixation plates|
|US9402735||May 23, 2013||Aug 2, 2016||DePuy Synthes Products, Inc.||Zero-profile interbody spacer and coupled plate assembly|
|US9414935||Apr 17, 2015||Aug 16, 2016||DePuy Synthes Products, Inc.||Zero-profile interbody spacer and coupled plate assembly|
|US9463097||May 9, 2014||Oct 11, 2016||DePuy Synthes Products, Inc.||Intervertebral implant|
|US9572681||Oct 28, 2011||Feb 21, 2017||DePuy Synthes Products, Inc.||Intervertebral implant|
|US20010008979 *||Mar 1, 2001||Jul 19, 2001||Bonutti Peter M.||Tissue press and system|
|US20020055755 *||Nov 15, 2001||May 9, 2002||Bonutti Peter M.||Apparatus and method for tissue removal|
|US20020099401 *||Mar 22, 2002||Jul 25, 2002||Bonutti Petel M.||Apparatus and method for tissue removal|
|US20030050708 *||Oct 24, 2002||Mar 13, 2003||Bonutti Peter M.||Tissue grafting material|
|US20040107003 *||Nov 24, 2003||Jun 3, 2004||Synthes (Usa)||Demineralized bone implants|
|US20050131548 *||Jan 31, 2005||Jun 16, 2005||Synthes||Demineralized bone-derived implants|
|US20050192600 *||Feb 24, 2005||Sep 1, 2005||Enrico Nicolo||Inguinal hernia repair prosthetic|
|US20090005882 *||Sep 8, 2008||Jan 1, 2009||Boyer Iii Michael L||Demineralized bone-derived implants|
|US20090269388 *||Jun 4, 2009||Oct 29, 2009||Musculoskeletal Transplant Foundation||Allograft bone composition having a gelatin binder|
|US20100322994 *||Aug 23, 2010||Dec 23, 2010||Isto Technologies, Inc.||Particulate cartilage system|
|USRE38522 *||Feb 28, 2002||May 25, 2004||Musculoskeletal Transplant Foundation||Malleable paste for filling bone defects|
|USRE39587||May 12, 2004||Apr 24, 2007||Musculoskeletal Transplant Foundation||Malleable paste for filling bone defects|
|EP0070328A1 *||Jul 21, 1981||Jan 26, 1983||Theurer, Karl Eugen, Prof.Dr.med.||Use of egg membranes and umbilical cord in unmodified or modified form|
|EP1701672A2 *||Dec 20, 2004||Sep 20, 2006||Osteotech, Inc.,||Tissue-derived mesh for orthopedic regeneration|
|EP1701672A4 *||Dec 20, 2004||Apr 27, 2011||Osteotech Inc||Tissue-derived mesh for orthopedic regeneration|
|WO2000040177A1 *||Dec 18, 1999||Jul 13, 2000||Lifenet||Composite bone graft, method of making and using same|
|U.S. Classification||424/423, 206/412, 128/898, 623/23.61, 424/549, 206/438|
|International Classification||A61K35/32, A61B17/58|
|Cooperative Classification||A61B17/58, A61K35/32|
|European Classification||A61K35/32, A61B17/58|