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Publication numberUS2701559 A
Publication typeGrant
Publication dateFeb 8, 1955
Filing dateAug 2, 1951
Priority dateAug 2, 1951
Publication numberUS 2701559 A, US 2701559A, US-A-2701559, US2701559 A, US2701559A
InventorsCooper William A
Original AssigneeCooper William A
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Apparatus for exfoliating and collecting diagnostic material from inner walls of hollow viscera
US 2701559 A
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Description  (OCR text may contain errors)

Feb. 8, 1955 w. A. COOPER 2,701,559 APPARATUS FOR EXFOLIATING AND COLLECTING DIAGNOSTIC MATERIAL FROM INNER WALLS 0F HOLLOW VISCERA Filed Aug. 2, 1951 SUCTION PRooucme MEANS AIR ' PRE SSURE.

Paooucms MEANS @474 1 ML a. f L L United States Patent APPARATUS FER EXFGLIATING AND COLLECT- ING DHAGNGSTIC MATERIAL FROM INNER WALLS 0F HOLLOW VISCERA William A. fiooper, New York, N. Y.

Application August 2, 1951, Serial No. 239,907

14 Claims. (Cl. 128-2) This invention relates to apparatus for obtaining diagnostic material by exfoliation ofliving cells from internal surfaces of hollow viscera, more particularly of the stomach and duodenum. I

Numerous attempts have been made to improve various technics for obtaining minute masses of cells from the lining of the stomach and/ or duodenum, so that such cells may be examined microscopically as an aid to the diagnosis of gastric pathology, including cancer of the stomach. Hitherto such technics have proved unsatisfactory because of the scanty amounts of. diagnostic material obtained thereby, principally through losses thereof by passage down the digestive tract, and also because of the rapid disintegration of such material by the digestive urces;

J A principal object of my invention is to provide an apparatus wherewith to obtain freshly exfoliated, minute masses of living cells from the inner walls of the stomach and duodenum, while at the same time avoiding injury to said Walls by the exfoliation, and avoiding deterioration of the removed cell groups by the action of digestive uices.

] Another object is to provide an apparatus including, as novel features thereof, an inflatable, abrasive balloon and an abrasive tip, adapted, respectively, for obtaining diagnostic material from the inner walls of the stomach and of the duodenum.

Still another object is to obtain, by exploratory test, exfoliated cellular material from various parts of the gastro-duodenal mucosa.

A further object is to provide an inflatable balloon having abradant fibers extending from and normal to the external surface thereof, whereby upon deflation of the balloon the fibers will move toward each other for the better gripping and protective retention between the clustered fibers of those cells which have been exfoliated from the lining of the stomach or other hollow viscera.

Other objects, uses, and advantages of my invention will appear from the following description, reference being had to the accompanying drawings, in which Fig. l is a general view of one embodiment of my t invention;

Fig. I! shows in vertical section an intermediate portion of the device of Fig. l

Fig. 3 is an enlarged sectional View on the line 3-3 of Fig. 2;

Fig. 4- illustrates a modified form of the invention showing the abrasive balloon in inflated condition;

Fig. 5 illustrates another form of abrasive means, showing the balloon in collapsed condition and a net enclosing the same; the net being shown as it would appear when supported by the balloon upon being inflated;

Fig. 6 is a view similar to Fig. 5, except that the net is omitted, and the collapsed balloon is shown partly cut away;

Fig. 7 shows, partly cut away, a third form of abrasive balloon, as well as the abrasive tip; and

Fig. 8 is a detail view of the abrasive tip and of parts adjacent thereto, shown to an enlarged scale.

Like numerals refer to like parts throughout the several views.

In the apparatus of Fig. 1, a first single-lumen tube 11 and a second single-lumen tube 12 are connected,

respectively, through tubes 13 and 14 of an adapter 15 (shown in detail in Fig. 2) to a first lumen 16 and a second lumen 17 of a double-lumen tube 18; the last being preferably of standard 16 French gauge. Tubes 11, 12, H

2,701,559 Patented Feb. 8, 1955 and 18 are flexible, and preferably are made of rubber.

The first lumen 16 of tube 18 opens into a hollow tip 19 having one or more perforations 20' through the wall thereof. The tip 19 is of a size to permit it to pass through the pylorus and into the duodenum; and it is preferably formed of, or plated with, a metal such as silver, which resists attack by the digestive juices. Tube 18 may be marked to indicate distances therealong of 45, 60, and centimeters (cm.-)- when measured from the end of tip 19.

The second lumen 17 of tube 18 is closed off by sealing means, such as by a plug 21 (Fig. 8).

Enclosing a length of about 8 cm. of tube 18, at its distal end, is an inflatable balloon 22, originally provided with an opening at each end thereof, as in Figs. 1, 4, 5, and 6, or With a single opening, as inv Figs. 7 and 8, for passage therethrough of the tip 19 and the tube 18. The balloon 22 preferably is formed of rubber latex of about the thickness of an ordinary toy balloon; but it may be formed of any other suitably impervious elastic material which is not attacked by the digestive juices. The shape of the balloon 22 is preferably such that the major part of its surface is cylindrical when it is inflated to a suitable degree (Figs. 1 and 4); its dimensions then being about 8 cm. to about 10 cm. in length, and about 2 cm. to about 5 cm. in diameter. When the balloon 22 is deflated, it collapses against the sides of the tube 18 (Figs. 5 and 6).

At the ends of said length of tube 18, the balloon 22, adjacent each end thereof, is attached air-tightly to the outside of tube 18, preferably by silk ties 23. Intermediate the ends of said length of tube 18 the external wall of the second lumen 17 thereof is provided with perforations 24 (Figs. 6 and 7) for passage of air into and out of the balloon 22 in the course of inflation and deflation thereof.

Distributed over the outer surface of the balloon 22 are numerous spaced-apart, porous, abradant bodies of an average dimension of about 2 millimeters (mm.); the various modifications thereof being adapted to exfoliate and to entrap living cells from the inner walls of a hollow viscus upon coming. into rubbing contact with said walls. Said bodies may be at distances apart of about 2 mm. to about 4 mm.

One form of said abradant bodies is shown in Figs. 1 and 7, as tufts 25, which are attached in any suitable manner to the outer surface of the balloon 22. Each tuft 25 is made up of a plurality of fibers or filaments; the free length of the individual fibers or filaments being about 2 mm. Such fibers may consist of textile threads or of fine rubber filaments, cemented to, or partly embedded in, the balloon 22.

A second form of my novel abradant bodies is shown in Fig. 4 as nodules 26 of a porous foam rubber, which are attached to the outer surface of the balloon 22.

A third form of said abradant bodies comprises knots 27 in a generally tubular open-weave veil or net 28 formed of textile fibers (Fig. 5). The net 28 encloses balloon 22, and is attached at its ends, along with the balloon 22, to the tube 18, by the ties 23. Each of knots 27 presents a loose, fuzzy exterior, which is adapted in exfoliate and to entrap living cells in a manner similar to that performed by the aforementioned tufts 25. When a form of my apparatus, which includes the net 28, it; being put to its intended use, the inflation of the balloon 22 presses the balloon against the interior of the net, including the knots 27, so that said knots are distributed over the surface of the balloon in tight engagement therewith, and operate as abradant bodies in the same general manner as do the tufts 25 and the nodules 26.

Connected to the outer end of tube 12 (Fig. l) is an ordinary compressible syringe air pump bulb 29, which is provided with an adjustable control valve 30 to permit deflation of the balloon 22. The balloon is inflatable only as to the portion thereof which is intermediate the ties 23 adjacent its two ends.

Connected to the outer end of tube 11 (Fig. l) is a three-way valve 31, which may be connected with any suitable suction means 9, or pressure producing means 10, indicated by blocks in Fig. 1, for aspirating materials entering the opening 20 in the tip 19, and for inflating a portion of the balloon, as will be described hereinafter with respect to the modification shown in Figs. 7 and 8 As will appear hereinafter, when the form of the invention shown in Figs. 7 and 8 is used, a compressible bulb air pump, like the pump 29, may be connected to one of the ports of the valve 31.

I may desire, however, to obtain diagnostic material from the inner walls of the duodenum; in which case I provide the tip 19 with an impervious inflatable cover 32, which preferably consists of a small area at the end of the balloon 22 which extends over the tip 19, as shown in Figs. 7 and 8. The outer surface of the cover 32 is provided with spaced apart tufts 2.5, in the manner that they are provided on the other portion of the balloon 22. When the tip 19 is provided with the cover 32, the former is no longer unobstructed, so that this form of the apparatus cannot be used to aspirate materials from a viscus into which the distal part of such apparatus is passed. By connecting a suitable air pump to the threeway valve 31, this cover portion 32 may be inflated so that it will conform to the shape of the duodenum and more effectively collect tissue cells from its walls.

I may designate generally as the distal part of my apparatus that portion thereof which is adapted to be swallowed and passed into the stomach, including the tip 19, the balloon 22, and the major portion of the double-lumen tube 18; and as the proximal part of the apparatus that portion thereof which normally does not enter the subjects mouth, including the adapter 15, tubes 11 and 12, bulb 29, and the three-way valve 31.

The following description of the use of my novel apparatus applies to the form thereof wherein the opening 20 in the tip 19 is unobstructed (Figs. 1, 4, 5, and 6).

All dentures are removed from the mouth of the subject, and the mouth is cleansed by rinsing. The deflated balloon 22 is dipped in Ringers solution and passed orally with the aid of small sips of the same solution. Local anesthesia of the posterior pharynx may be used to minimize the gag reflex. Once the balloon is past the epiglottis, it is advanced easily into the stomach as the subject swallows.

After the tube is beyond the 60 cm. mark, all gastric residue is aspirated and discarded. The balloon then is inflated with a quantity of air which has been shown by preliminary test to be suitable. Proper position is attained by withdrawing the tube until the inflated balloon, which is checked by meeting the cardia, causes a vomiting reflex. The latter furnishes a standard for the positioning of the balloon well within the stomach.

Peristalsis, initiated by inflation of the balloon, and aided by gentle manipulation of the tube 18, transfers the balloon from the cardia to the pylorus. The balloon is deflated at the pylorus so that it may enter the canal. Slow inflation of the balloon in the pyloric canal causes the balloon to move back into the antrum and it is then drawn back to the cardia. This procedure is repeated five or more times over a period of an hour so that the abradant bodies come in contact with the entire gastric mucosa. During this period it is preferable to continue gentle suction on an open exit of the three-way valve 31 so as to prevent interference of accumulating gastric juice with the contact of the abradant bodies with the mucosa. At the end of a suitable period of test, the balloon is deflated and withdrawn. In the laboratory any fragments of tissue seen on the silk or rubber tufts or brushes are removed by a cupped forceps and smeared directly onto slides prepared with a thin film of albumin. These slides are placed in an ether-alcohol fixative. The entire balloon is then promptly immersed in Ringers solution, and without delay is shaken in the solution until substantially all of the cells entrapped by the abradant bodies are dislodged and dispersed throughout the medium.

From this point on the routine methods of separation of the cells from the solution, fixation of the cells, smearing them on glass slides. staining the smears, and examining them microscopically, are carried out according to suitable cytologic procedures.

It will be observed that in the form of the invention shown in Figs. 1, 7, and 8, the tufts of fiber 25 spread out as the balloon is inflated, and move toward each other as the balloon is deflated, since they extend sub stantially normally to the external surface of the balloon. Thus when cells are loosened from the lining of the stomach by the brushing action of the fibers, the cells lodge between the fibers, and upon deflation of the balloon the fibers move toward one another, thereby tightly entrapping the cells and shielding and protecting the cells from decomposition by the gastric juices.

The technic of using the form of the apparatus wherein the tip 19 is provided with a cover 32, for the purpose of obtaining diagnostic material from the duodenum, does not differ materially from the technic just described, except in two respects. The first of these respects is that the stomach of the patient should be emptied as far as possible by any suitable procedure prior to the passage of such apparatus into the stomach; and that such passage should be accomplished without the aid of swallowed liquid and after preliminary light local anesthesia of the posterior pharynx. The second respect in which the above technic is changed is that, after deflation of the balloon at the pylorus, the covered tip 19 is permitted to pass into the duodenum, and the portion 32 of the balloon is inflated and permitted to remain in the duodenum until enough time has elapsed for the peristalsis set up in the duodenum to lead to a suitable exfoliation of the lining thereof. During this time the tube 18 may be gently manipulated at intervals to increase the scrubbing effect of the tufts on the cover 32.

I have employed representative embodiments of my novel apparatus in collecting cellular material from many scores of patients with clinical symptoms of gastric disease. The more important of my findings resulting from such tests are:

(1) Normal gastric mucosa resists mechanical exfoliation by the means and methods that I have described herein.

(2) Abnormally proliferating gastric cells, which are characteristic of malignancy, are fairly readily exfoliated by abradant means herein described.

(3) The ability to fix and stain such exfoliated cells with a minimum of delay yields better structural details under the microscope, and consequently definitely greater accuracy in recognizing malignant conditions.

Although the foregoing description relates to the preferred embodiment of my invention, various modifications and changes in minor details of my novel apparatus may be made without departing from the spirit of the invention as the same is defined in the appended claims.

I claim:

1. In apparatus of the character described, an inflatable balloon having attached to its external surface a plurality of spaced apart, porous, abradant bodies; each of said bodies comprising a small tuft of textile fibers; the free length of each fiber being of the order of two millimeters; said tufts being adapted to exfoliate and to entrap living cells from the inner walls of a hollow viscus upon coming into rubbing contact with said walls.

2. In apparatus of the character described, an inflatable balloon having attached to its external surface a plurality of spaced apart, porous, abradant bodies; each of said bodies comprising a small tuft of rubber filaments; the free length of each filament being of the order of two millimeters; said tufts being adapted to exfoliate and to entrap living cells from the inner walls of a hollow viscus upon coming into rubbing contact with said walls.

3. In apparatus of the character described, an infiatable balloon having attached to its outer surface a plurality of spaced apart, porous, abradant bodies; each of said bodies comprising a small mass of highly porous rubber of an average dimension of about two millimeters; said masses being adapted to exfoliate and to entrap living cells from the inner walls of a hollow viscus upon coming into rubbing contact with said walls.

4. In apparatus of the character described, the combination of a length of double-lumen tubing, means sealing the end of one lumen of the tubing at its distal end, an apertured tip which is adapted to pass through the pylorus and into the duodenum, means connecting the other lumen of the tubing to the apertured tip, an elongated inflatable balloon enveloping the distal end of the tubing and covering said tip, means securing the balloon air-tightly around the distal end portion of the tubing and also at a point spaced longitudinally along the tubing from the first point of securement and near the apertured tip thereby to provide two balloon sections, one of said balloon sections enveloping the tubing at its distal end and the other balloon section surrounding the apertured tip, a lateral perforation in said one lumenv providing: communication between the interior of said one lumen. and the interior of said one balloon section, a plurality of islands of tissue abrading material on the external surface of the portion of the balloon section surrounding the apertured' tip, said islands being adapted to'exfoliate and to entrap living cells from the inner walls of a hollow viscus such. as the duodenum up'on coming into' rubbing contact with the walls thereof, and means for separatel; controlling the inflation and deflation of the two balloon sections.

5. In an apparatus of the class described, the combination of a flexible tube having a closed end, a generally cylindrical flexible expansible balloon-like member secured over and sealed against the outer walls of the tube at longitudinally spaced positions thereon, lateral openings in the tube providing communication between the interior of the tube and the interior of the balloon-like member, means at the other end of the tube for forcing air into the balloon-like member, and dispersed small areas of fibrous material on the outer surface of the balloon-like member.

6. In an apparatus of the class described, the combination of a flexible tube having a closed end, a generally cylindrical flexible expansible balloon-like member secured over and sealed against the outer walls of the tube at longitudinally spaced positions thereon, lateral openings in the tube providing communication between the interior of the tube and the interior of the balloon-like member, means at the other end of the tube for forcing air into the balloon-like member, and a net of fibrous material enveloping the balloon-like member.

7. Apparatus for removing tissue cells from the walls of an internal cavity of the body, such as the stomach, comprising a flexible tube, an inflatable elastic balloonlike member connected to one end of the tube, means connected to the other end of the tube to inflate the member, and a plurality of exfoliating and cell-retaining projections on the external surface of the balloon.

8. Apparatus for exfoliating and collecting diagnostic material from the inner walls of internal viscera which comprises, an expansible elastic thin walled balloonlike member inflatable approximately to the size of the viscera into which it is to be inserted, a tubular means having one end secured to the member in airtight sealed relation and having an opening in communication with the interior of the member, means secured to the other end of the tubular means for supplying air under pressure through the tubular means to the member to inflate the latter and for providing a vent to the atmosphere when the member is to be deflated, and exfoliating and particulate matter collecting means around the external surface of the member.

9. The combination set forth in claim 8, in which the exfoliating and paticulate matter collecting means comprises a large number of abradant bodies distributed in spaced relation over the external surface of the balloon-like member.

10. The combination set forth in claim 8, in which the exfoliating and particulate matter collecting means comprises an open weave net formed of textile fibers enclosing the balloon-like member and secured to the tubular means in position to surround the balloon-like member when the latter is inflated.

11. Apparatus for exfoliating and collecting diagnostic material from the inner walls of internal viscera which comprises, proximal parts and distal parts, the proximal parts comprising a pair of single lumen tubes, means secured at the proximal end of one of the tubes selectively to supply air under pressure to the tube or to release air therefrom, means secured to the proximal end of the other tube selectively to apply air under pressure, or to produce a suction effect, the distal parts of said apparatus including the major portion of a length of double-lumen tube, means forming part of the proximal portion of the apparatus for connecting the other ends of the single lumen tubes respectively with the lumens of the double-lumen tube, the distal parts of the apparatus further including a metal point secured at the distal end of the double-lumen tube and having a passageway therein leading from the distal end of one of the lumens of the double-lumen tube to its external surface, means closing the distal end of the other lumen of the double-lumen tube, an elastic inflatable balloon-like member of sufficient size to en- 6 able it to be. inflated substantially to the size of the viscera into which it is to be inserted, means securing said member around the distal end portion of the double lumen tube and around said metal point; an opening inthe wall of the double-lumen tube: so as to communicate" the interior of that lumen having a closed distal end with the interior of the balloon-like member, means preventing communication between the portion of said member which surrounds the distal end of the double-lumen tube from that portion which surrounds the weighted end, and abradant exfoliating means around the outer surface of at least the portion of said member which surrounds the weighted end for exfoliating and collecting particulate matter from the walls of a smaller body cavity such as the duodenum adjacent a larger body cavity such as the stomach.

12. Apparatus for exfoliating and collecting diagnostic material from the inner walls of internal viscera which comprises, first and second single lumen tubes; means secured to one end of the first tube selectively to supply air under pressure to the tube or to release air therefrom; means secured to one end of the second tube selectively to apply air under pressure, or to produce a suction effect; a length of double-lumen tube having at one end first and second lumens respectively connected to the first and second single lumen tubes; a metallic element secured at the other end of the double-lumen tube and having a passageway therein leading from the first lumen of the double-lumen tube to its external surface; means closing the end of the second lumen near said element; an elastic inflatable balloon-like member of suflicient size to enable it to be inflated substantially to the size of the viscera into which it is to be inserted; means securing said member around the end portion of the double-lumen tube near said element, an opening in the wall of the double-lumen tube so as tocommunicate the interior of the second lumen with the interior of the balloon-like member; and abradant exfoliating means around the outer surface of said member for exfoliating and collecting particulate matter from the walls of viscera.

13. Apparatus for exfoliating and collecting diagnostic material from the inner walls of internal viscera which comprises, first and second single lumen tubes; means secured to one end of the first tube selectively to supply air under pressure to the tube or to release air therefrom; means secured to one end of the second tube selectively to apply air under pressure, or to produce a suction effect, a length of double-lumen tube having at one end first and second lumens respectively connected to the first and second single lumen tubes; a metallic element secured at the other end of the doublelumen tube and having a passageway therein leading from the first lumen of the double-lumen tube to its a external surface; means closing the end of the second lumen near said element; an elastic inflatable balloonlike member of suflicient size to enable it to be inflated substantially to the size of the viscera into which it is to be inserted; means securing said member around the end portion of the double-lumen tube and around said element, thereby preventing communication between the portion of said member which surrounds the doublelumen tube from that portion which surrounds said element; an opening in the wall of the double-lumen tube so as to communicate the interior of the second lumen with the interior of that portion of the balloonlike member which surrounds the double-lumen tube and abradant exfoliating means around the outer surface of at least the portion of said member which surrounds said element for exfoliating and collecting particulate matter from the walls of a smaller body cavity such as the duodenum adjacent a larger body cavity such as the stomach.

14. Apparatus for removing tissue cells from the walls of an internal cavity of the body, the combination of a thin wall elastic balloon-like member having a plurality of exfoliating and cell retaining fibers projecting from the external surface thereof, a flexible tube having one end connected to said member, and means connected to the other end of said tube for supplying air under pressure to inflate the member and having means for relieving the pressure to permit deflation of the member.

(References on following page) References Cited in the file of this patent UNITED STATES PATENTS Dorogi Sept. 17, 1935 Allyn Apr. 1, 1941 5 Winder Sept. 28, 1943 Wild Nov. 22, 1949 8 OTHER REFERENCES Surgery, April 1949, vol. 25, No. 4, page 603. A copy of this publication is available in Div. 55 of the Patent Ofiice.

American Journal of Clinical Pathology, vol. 19, No. 9, September 1949, pages 891-894. A copy of this publication is available at the Scientific Library of the Patent Ofiice.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US2014426 *Jun 13, 1932Sep 17, 1935Hungarian Rubber Goods FactoryInflatable rubber article provided with fiber cover and process for their production
US2236842 *Jul 13, 1939Apr 1, 1941William N AllynEndoscopic instrument
US2330399 *Sep 11, 1937Sep 28, 1943American Anode IncDistensible bag catheter
US2489067 *May 22, 1947Nov 22, 1949Andrew E CarlsenIntubator apparatus for intestinal intubation
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US2767703 *Jan 7, 1955Oct 23, 1956Herbert E NieburgsExploratory device for cell specimens
US2839051 *Feb 24, 1956Jun 17, 1958Chester Martin HCervicotome
US2955591 *May 20, 1954Oct 11, 1960Kenneth S MacleanAbrasive cytologic instruments
US2955592 *Dec 29, 1955Oct 11, 1960Maclean Kenneth SDiagnostic instrument
US3033194 *Nov 8, 1960May 8, 1962Lippert Henry EBiopsy capsule and apparatus
US3037495 *Jul 17, 1959Jun 5, 1962Naz John FBiopsy device
US3074396 *Apr 16, 1959Jan 22, 1963Maclean Kenneth SDiagnostic instrument
US3224434 *Nov 6, 1962Dec 21, 1965Waldemar Medical Res FoundatioCell collector
US3227154 *May 11, 1962Jan 4, 1966Galen B CookDiagnostic bag with impressionable outer surface and method of using it
US3247841 *May 29, 1961Apr 26, 1966Cook Galen BDiagnostic method
US3320957 *May 21, 1964May 23, 1967Sokolik EdwardSurgical instrument
US3407817 *Jul 26, 1965Oct 29, 1968Air Reduction IncCatheter with cuff inflater and indicator
US3435826 *May 27, 1964Apr 1, 1969Edwards Lab IncEmbolectomy catheter
US3448739 *Aug 22, 1966Jun 10, 1969Edwards Lab IncDouble lumen diagnostic balloon catheter
US3483859 *Nov 29, 1967Dec 16, 1969Pittman Fred EString for marking bleeding in upper gastro-intestinal tract
US3635223 *Dec 2, 1969Jan 18, 1972Us Catheter & Instr CorpEmbolectomy catheter
US3664328 *Apr 28, 1971May 23, 1972Moyle Henry Dinwoodey JrCancer test specimen gathering device
US3670732 *May 11, 1970Jun 20, 1972Ralph R RobinsonVacuum curette
US3683890 *Oct 2, 1970Aug 15, 1972Beal Charles BCarrier system for delivery of an end of an elongated member to the upper gastrointestinal tract
US3750646 *Dec 16, 1971Aug 7, 1973Patterson CTransport system for bacteria with provisions for carbogenophilic organisms
US3774596 *Jun 29, 1971Nov 27, 1973Cook GCompliable cavity speculum
US3799173 *Mar 24, 1972Mar 26, 1974J KamenTracheal tubes
US3838681 *Dec 29, 1972Oct 1, 1974Dalton JDevice for collection of cells from the vagina
US3923061 *Nov 4, 1974Dec 2, 1975Rossignol JacquesTool for hygiene and care of the cavities of the body
US3954499 *Apr 25, 1974May 4, 1976Max HankinMethod and apparatus for removing dew from a green
US4018230 *Apr 2, 1975Apr 19, 1977Kazuo OchiaiCervical dilator
US4228801 *Nov 21, 1978Oct 21, 1980Elektromedical Company S.R.L.Dilator for application in medical field
US4231738 *Dec 9, 1977Nov 4, 1980Francesco RiitanoCanal instrument for eliminating interference, widening the opening and the contemporaneous flared reaming of the first two-thirds of the dental radicular canals
US4274676 *Jan 18, 1980Jun 23, 1981Chapel Nimrod TApparatus for removing material
US4372295 *May 19, 1980Feb 8, 1983Richard Wolf GmbhEndoscopes
US4438977 *May 18, 1981Mar 27, 1984Chapel Nimrod TApparatus for removing material
US4465072 *Feb 22, 1983Aug 14, 1984Taheri Syde ANeedle catheter
US4484579 *Jul 19, 1982Nov 27, 1984University Of PittsburghCommissurotomy catheter apparatus and method
US4733665 *Nov 7, 1985Mar 29, 1988Expandable Grafts PartnershipExpandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4776337 *Jun 26, 1986Oct 11, 1988Expandable Grafts PartnershipExpandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4890611 *Apr 5, 1988Jan 2, 1990Thomas J. FogartyEndarterectomy apparatus and method
US4979947 *Oct 10, 1985Dec 25, 1990Berman Irwin REncapsulated expandible continence device
US5019090 *Sep 1, 1988May 28, 1991Corvita CorporationRadially expandable endoprosthesis and the like
US5078723 *Dec 19, 1990Jan 7, 1992Medtronic, Inc.Atherectomy device
US5092877 *Jul 5, 1990Mar 3, 1992Corvita CorporationRadially expandable endoprosthesis
US5156610 *Nov 26, 1991Oct 20, 1992Evi CorporationCatheter atherotome
US5160342 *Dec 30, 1991Nov 3, 1992Evi Corp.Endovascular filter and method for use thereof
US5176692 *Dec 9, 1991Jan 5, 1993Wilk Peter JMethod and surgical instrument for repairing hernia
US5188595 *Jun 28, 1991Feb 23, 1993LaserscopeMethod for enhanced retention of balloon catheter in body cavity
US5197948 *Jan 3, 1991Mar 30, 1993Kamran GhodsianIntra-abdominal organ manipulator, irrigator and aspirator
US5205816 *Apr 13, 1992Apr 27, 1993O. R. Concepts, Inc.Laparoscopic irrigator-aspirator blunt dissector
US5211651 *Aug 16, 1990May 18, 1993Evi CorporationCatheter atherotome
US5226913 *Mar 2, 1992Jul 13, 1993Corvita CorporationMethod of making a radially expandable prosthesis
US5236446 *Mar 2, 1989Aug 17, 1993Dumon Jean FrancoisTubular endoprosthesis for anatomical conduits
US5250070 *May 28, 1991Oct 5, 1993Parodi Juan CLess traumatic angioplasty balloon for arterial dilatation
US5282484 *Jul 28, 1992Feb 1, 1994Endovascular Instruments, Inc.Method for performing a partial atherectomy
US5304117 *Nov 27, 1992Apr 19, 1994Wilk Peter JClosure method for use in laparoscopic surgery
US5359995 *Feb 5, 1992Nov 1, 1994Sewell Jr FrankMethod of using an inflatable laparoscopic retractor
US5379759 *Jul 21, 1993Jan 10, 1995Sewell, Jr.; Frank K.Retractor for endoscopic surgery
US5395331 *Feb 23, 1993Mar 7, 1995Minnesota Mining And Manufacturing CompanyRetrograde coronary sinus catheter having a ribbed balloon
US5400770 *Feb 28, 1994Mar 28, 1995Nakao; Naomi L.Device utilizable with endoscope and related method
US5405755 *Sep 29, 1993Apr 11, 1995Daymark Medical Industries, Inc.Testing culture sample of fibrin obtained from catheter lining and outer end without removing the catheter for infection
US5407807 *Apr 23, 1993Apr 18, 1995Daymark Medical Industries, Inc.Method and apparatus for detecting sepsis causation in a catheter
US5409012 *Dec 30, 1993Apr 25, 1995Boston Scientific CorporationSample collection using catheter with expandable member
US5423745 *Jul 6, 1994Jun 13, 1995Research Medical, Inc.Irregular surface balloon catheters for body passageways and methods of use
US5423799 *Jan 28, 1993Jun 13, 1995Medtronic, Inc.Medical device for removing material from a body vessel
US5437638 *Dec 1, 1994Aug 1, 1995The United States Of America As Represented By The Secretary Of The Department Of Health And Human ServicesMultifinger topocatheter tip for multilumen catheter for angioplasty and manipulation
US5509900 *Oct 15, 1993Apr 23, 1996Kirkman; Thomas R.Apparatus and method for retaining a catheter in a blood vessel in a fixed position
US5522883 *Feb 17, 1995Jun 4, 1996Meadox Medicals, Inc.Endoprosthesis stent/graft deployment system
US5599298 *Dec 30, 1993Feb 4, 1997Boston Scientific CorporationBodily sample collection balloon catheter method
US5603698 *Aug 23, 1995Feb 18, 1997Boston Scientific CorporationProsthesis delivery system
US5620418 *Dec 7, 1994Apr 15, 1997Minnesota Mining And Manufacturing CompanyRetrograde coronary sinus catheter
US5643297 *Mar 10, 1995Jul 1, 1997Endovascular Instruments, Inc.Intra-artery obstruction clearing apparatus and methods
US5643298 *May 6, 1996Jul 1, 1997Nordgren; Gregory N.Intra-artery obstruction clearing apparatus and methods
US5649902 *Mar 8, 1995Jul 22, 1997Yoon; InbaeFor introduction into an anatomical cavity
US5653690 *Oct 30, 1995Aug 5, 1997Medtronic, Inc.Catheter having a balloon with retention enhancement
US5665098 *Jul 23, 1996Sep 9, 1997Endovascular Instruments, Inc.Unitary removal of plaque
US5690643 *Feb 20, 1996Nov 25, 1997Leocor, IncorporatedStent delivery system
US5693014 *May 15, 1995Dec 2, 1997Boston Scientific CorporationBalloon catheter
US5702413 *Jan 11, 1996Dec 30, 1997Scimed Life Systems, Inc.Curved bristle atherectomy device and method
US5702419 *Sep 21, 1994Dec 30, 1997Wake Forest UniversityExpandable, intraluminal stents
US5713369 *Sep 13, 1995Feb 3, 1998Vance Products Inc.Uterine endometrial tissue sample brush
US5746745 *Mar 1, 1996May 5, 1998Boston Scientific CorporationBalloon catheter
US5746758 *Oct 21, 1996May 5, 1998Evi CorporationIntra-artery obstruction clearing apparatus and methods
US5769821 *Mar 28, 1997Jun 23, 1998Quinton Instrument CompanyCatheter tip retainer
US5807326 *Mar 6, 1995Sep 15, 1998Minnesota Mining And Manufacturing CompanyRetrograde coronary sinus catheter
US5868779 *Aug 15, 1997Feb 9, 1999Ruiz; Carlos E.Apparatus and methods for dilating vessels and hollow-body organs
US5902333 *Aug 21, 1995May 11, 1999Boston Scientific CorporationProsthesis delivery system with dilating tip
US5919145 *Jan 24, 1997Jul 6, 1999Boston Scientific CorporationBodily sample collection balloon catheter
US5922950 *Oct 22, 1997Jul 13, 1999Westinghouse Savannah River CompanyDepth-discrete sampling port
US5976155 *Mar 5, 1999Nov 2, 1999Advanced Cardiovascular Systems, Inc.System for removably securing a stent on a catheter assembly and method of use
US5984964 *Oct 31, 1996Nov 16, 1999Boston Scientific CorporationProthesis delivery system
US6001112 *Apr 10, 1998Dec 14, 1999Endicor Medical, Inc.Rotational atherectomy device
US6017364 *May 21, 1998Jan 25, 2000Endovascular Technologies, Inc.Intraluminal repair device and catheter
US6045531 *Jul 22, 1998Apr 4, 2000Chase Medical Inc.Catheter having a lumen occluding balloon and method of use thereof
US6068608 *May 1, 1997May 30, 2000Chase Medical, Inc.Method of using integral aortic arch infusion clamp
US6071263 *Jun 7, 1995Jun 6, 2000Kirkman; Thomas R.Apparatus and method for retaining a catheter in a blood vessel in a fixed position
US6096054 *Oct 23, 1998Aug 1, 2000Scimed Life Systems, Inc.Expandable atherectomy burr and method of ablating an occlusion from a patient's blood vessel
US6132397 *May 1, 1997Oct 17, 2000Chase Medical Inc.Integral aortic arch infusion clamp catheter
US6165187 *Aug 16, 1996Dec 26, 2000Endo Vascular Instruments, Inc.Method of enlarging a lumen of an artery
US6206898Mar 1, 1999Mar 27, 2001Endicor Medical, Inc.Rotational atherectomy device
US6241699Jul 22, 1998Jun 5, 2001Chase Medical, Inc.Catheter system and method for posterior epicardial revascularization and intracardiac surgery on a beating heart
US6241739 *Nov 12, 1999Jun 5, 2001Altair Instruments, Inc.Microdermabrasion device and method of treating the skin surface
US6248128Nov 26, 1997Jun 19, 2001Wake Forest UniversityExpandable intraluminal stents
US6277122 *Oct 15, 1999Aug 21, 2001Sdgi Holdings, Inc.Distraction instrument with fins for maintaining insertion location
US6344053Apr 5, 1999Feb 5, 2002Medtronic Ave, Inc.Endovascular support device and method
US6346086Apr 23, 1999Feb 12, 2002Cook Urological Inc.Endocervical and exocervical cell collection device
US6358266 *Oct 9, 1996Mar 19, 2002General Surgical Innovations, Inc.Active cannulas
US6416526Jun 8, 2000Jul 9, 2002Scimed Life Systems, Inc.Expandable atherectomy burr
US6416535Sep 28, 1999Jul 9, 2002Endovascular Technologies, Inc.Artificial graft and implantation method
US6416539Jun 29, 1998Jul 9, 2002Medex, Inc.Controlled length intraluminal implant
US6432133Nov 16, 2000Aug 13, 2002Advanced Cardiovascular Systems, Inc.Expandable stents and method for making same
US6443966Oct 16, 1997Sep 3, 2002Intravascular Medical, Inc.Surgical instrument
US6451036Jun 12, 2000Sep 17, 2002Endicor Medical, Inc.Rotational atherectomy system with stationary cutting elements
US6451037Nov 22, 2000Sep 17, 2002Scimed Life Systems, Inc.Expandable atherectomy burr with metal reinforcement
US6454779Oct 4, 1999Sep 24, 2002Endicor Medical, Inc.Rotational atherectomy device
US6478807Jun 8, 2000Nov 12, 2002Advanced Cardiovascular Systems, Inc.Pre-formed expandable member having grooves
US6482217Sep 7, 2000Nov 19, 2002Endicor Medical, Inc.Neuro thrombectomy catheter
US6500183Nov 9, 2000Dec 31, 2002Altair Instruments, IncMicrodermabrasion device
US6527783Oct 27, 2000Mar 4, 2003Edge Systems CorporationMicrodermabrasion and suction massage apparatus and method
US6558349Apr 25, 2000May 6, 2003Thomas R. KirkmanApparatus and method for retaining a catheter in a blood vessel in a fixed position
US6569192Aug 18, 2000May 27, 2003Advanced Cardiovascular Systems, Inc.System for removably securing a stent on a catheter assembly and method of use
US6585747Apr 14, 2000Jul 1, 2003Advanced Cardiovascular Systems, Inc.Interdigitating polymeric endcap for enhanced stent retention
US6592595Mar 31, 2000Jul 15, 2003Edge Systems CorporationMicrodermabrasion and suction massage apparatus and method
US6596022Feb 8, 2001Jul 22, 2003Advanced Cardiovascular Systems, Inc.Expandable stents and method for making same
US6610085Nov 13, 1996Aug 26, 2003Endovascular Technologies, Inc.Intraluminal repair device and method
US6620191Mar 27, 2001Sep 16, 2003Advanced Cardiovascular Systems, Inc.System for releasably securing a stent on a catheter assembly and method of use
US6620193Jun 1, 1999Sep 16, 2003Advanced Cardiovascular Systems, Inc.Method of deploying a stent in a body lumen
US6626933Jun 1, 1999Sep 30, 2003Advanced Cardiovascular Systems, Inc.Expandable stents and method for making same stent delivery system
US6629983Oct 27, 2000Oct 7, 2003Edge Systems CorporationApparatus and method for skin/surface abrasion
US6629991Jun 1, 1999Oct 7, 2003Advanced Cardiovascular Systems, Inc.Expandable stents and method for making same
US6656219Nov 22, 2000Dec 2, 2003Dominik M. WiktorIntravascular stent
US6663661Oct 31, 2001Dec 16, 2003Medtronic Ave, Inc.Endovascular support device and method
US6666874Sep 17, 1999Dec 23, 2003Endicor Medical, Inc.Rotational atherectomy system with serrated cutting tip
US6666880Jun 19, 2001Dec 23, 2003Advised Cardiovascular Systems, Inc.Method and system for securing a coated stent to a balloon catheter
US6681773May 24, 2001Jan 27, 2004Chase Medical, Inc.Kit and method for use during ventricular restoration
US6685718Jul 31, 2000Feb 3, 2004Scimed Life Systems, Inc.Expandable ablation burr
US6689159May 1, 2003Feb 10, 2004Advanced Cardiovascular Systems, Inc.Expandable stents and method for making same
US6695853Nov 21, 2001Feb 24, 2004Emed, Inc.Microdermabrasion system and method of use
US6702763May 24, 2001Mar 9, 2004Chase Medical, L.P.Sizing apparatus and method for use during ventricular restoration
US6702844Sep 27, 1999Mar 9, 2004Endovascular Technologies, Inc.Artificial graft and implantation method
US6800083Apr 9, 2001Oct 5, 2004Scimed Life Systems, Inc.Compressible atherectomy burr
US6827733Sep 24, 2003Dec 7, 2004Medtronic Ave, Inc.Endovascular support device and method
US6875229Jan 27, 2003Apr 5, 2005Advanced Cardiovascular Systems, Inc.Stent and catheter assembly and method for treating bifurcations
US6896697Dec 30, 2002May 24, 2005Advanced Cardiovascular Systems, Inc.Intravascular stent
US6896699Oct 8, 2003May 24, 2005Advanced Cardiovascular Systems, Inc.Stent and catheter assembly and method for treating bifurcations
US6899729Dec 18, 2002May 31, 2005Advanced Cardiovascular Systems, Inc.Stent for treating vulnerable plaque
US6908479May 1, 2003Jun 21, 2005Advanced Cardiovascular Systems, Inc.Expandable stents and method for making same
US6911031 *Sep 24, 2001Jun 28, 2005Janelle Marie MuldnerSingle-hand operable microdermabrasion device
US6923828Nov 22, 2000Aug 2, 2005Medtronic, Inc.Intravascular stent
US6942680Jul 24, 2001Sep 13, 2005Jeffrey GrayzelStiffened balloon catheter for dilatation and stenting
US6951555Nov 7, 2000Oct 4, 2005Chase Medical, L.P.Catheter having integral expandable/collapsible lumen
US6955688Jul 16, 2003Oct 18, 2005Advanced Cardiovascular Systems, Inc.Stent and catheter assembly and method for treating bifurcations
US6959711Jun 5, 2003Nov 1, 2005Chase Medical, L.P.Kit and method for use during ventricular restoration
US6979346Aug 8, 2001Dec 27, 2005Advanced Cardiovascular Systems, Inc.System and method for improved stent retention
US6994093May 24, 2001Feb 7, 2006Chase Medical, L.P.Ventricular restoration shaping apparatus and method of use
US7077860Jun 24, 2004Jul 18, 2006Advanced Cardiovascular Systems, Inc.Medical insert coated with compound that bonds to heparin
US7172610Oct 17, 2003Feb 6, 2007Ev3 Endovascular, Inc.Rotational atherectomy system with stationary cutting elements
US7179269May 20, 2002Feb 20, 2007Scimed Life Systems, Inc.Apparatus and system for removing an obstruction from a lumen
US7198675Sep 30, 2003Apr 3, 2007Advanced Cardiovascular SystemsStent mandrel fixture and method for selectively coating surfaces of a stent
US7235088Jul 19, 2002Jun 26, 2007Ev3 Endovascular, Inc.Neuro thrombectomy catheter
US7258697Dec 22, 2003Aug 21, 2007Advanced Cardiovascular Systems, Inc.Stent with anchors to prevent vulnerable plaque rupture during deployment
US7258891Apr 7, 2003Aug 21, 2007Advanced Cardiovascular Systems, Inc.Reduct coating, controlling thickness in support contactor zones
US7291146Sep 10, 2004Nov 6, 2007Minnow Medical, Inc.Selectable eccentric remodeling and/or ablation of atherosclerotic material
US7297159Jul 21, 2004Nov 20, 2007Advanced Cardiovascular Systems, Inc.Selective coating of medical devices
US7311719Apr 8, 2003Dec 25, 2007General Surgical Innovations, Inc.Active cannulas
US7316710Dec 30, 2002Jan 8, 2008Advanced Cardiovascular Systems, Inc.Flexible stent
US7328707 *May 22, 2003Feb 12, 2008Boston Scientific Scimed, Inc.Implant system and method for bulking tissue
US7479147Dec 14, 2000Jan 20, 2009Ev3 Endovascular, Inc.Rotational atherectomy device
US7485088Sep 5, 2002Feb 3, 2009Chase Medical L.P.Method and device for percutaneous surgical ventricular repair
US7513907Apr 22, 2005Apr 7, 2009Advanced Cardiovascular Systems, Inc.Expandable stents and method for making same
US7553377Apr 27, 2004Jun 30, 2009Advanced Cardiovascular Systems, Inc.Apparatus and method for electrostatic coating of an abluminal stent surface
US7563324Dec 29, 2003Jul 21, 2009Advanced Cardiovascular Systems Inc.System and method for coating an implantable medical device
US7604700Jan 16, 2007Oct 20, 2009Advanced Cardiovascular Systems, Inc.Stent mandrel fixture and method for selectively coating surfaces of a stent
US7632307Dec 16, 2004Dec 15, 2009Advanced Cardiovascular Systems, Inc.Abluminal, multilayer coating constructs for drug-delivery stents
US7648727Aug 26, 2004Jan 19, 2010Advanced Cardiovascular Systems, Inc.Forming hydrogel sacrificial layer, mounting, crimping, coating
US7651508Aug 31, 2004Jan 26, 2010Vierk Dan ADiamAbrasion system
US7658742Mar 19, 2003Feb 9, 2010Envy Medical, Inc.Skin treatment system and method of use
US7662163Sep 13, 2005Feb 16, 2010Jeffrey GrayzelStiffened balloon apparatus with increased flexibility
US7678120May 3, 2006Mar 16, 2010Axia Medsciences, LlcInstruments and techniques for controlled removal of epidermal layers
US7742795Mar 28, 2006Jun 22, 2010Minnow Medical, Inc.Tuned RF energy for selective treatment of atheroma and other target tissues and/or structures
US7749173 *Oct 26, 2006Jul 6, 2010Daniel LarkinApparatus for simultaneously collecting exocervical and endocervical samples
US7753950Aug 7, 2007Jul 13, 2010Advanced Cardiovascular Systems, Inc.Stent and catheter assembly and method for treating bifurcations
US7771445Jun 20, 2002Aug 10, 2010Ev3 Endovascular, Inc.Rotational atherectomy system with stationary cutting elements
US7789886Nov 3, 2003Sep 7, 2010Axia Medsciences, LlcInstruments and techniques for controlled removal of epidermal layers
US7837695May 22, 2007Nov 23, 2010Dermasweep, Inc.Skin treatment system
US7842055Jul 21, 2006Nov 30, 2010Ev3 Endovascular, Inc.Neuro thrombectomy catheter
US7867547Dec 19, 2005Jan 11, 2011Advanced Cardiovascular Systems, Inc.spray coating with anti-coagulant, platelet inhibitor and/or pro-healing substance; cured via electrical resistance heater
US7879051May 20, 2002Feb 1, 2011Christopher Paul SwainFlexible device for transfixing and joining tissue
US7883537Dec 21, 2004Feb 8, 2011Jeffrey GrayzelMethods for configuring expandable devices
US7905841Aug 31, 2005Mar 15, 2011Boston Scientific Scimed, Inc.Cytology device and related methods of use
US7927362Jul 21, 2005Apr 19, 2011Boston Scientific Scimed, Inc.Laser ablated elastomer sheath profiles to enables stent securement
US7931663 *Dec 1, 2005Apr 26, 2011Angioscore, Inc.Balloon catheter with non-deployable stent
US7947207Sep 15, 2006May 24, 2011Abbott Cardiovascular Systems Inc.Method for retaining a vascular stent on a catheter
US7951156Nov 22, 2006May 31, 2011Envy Medical, Inc.Skin treatment system and method of use
US7955379Aug 7, 2007Jun 7, 2011Abbott Cardiovascular Systems Inc.Stent and catheter assembly and method for treating bifurcations
US7959664Mar 15, 2006Jun 14, 2011Medinol, Ltd.Flat process of drug coating for stents
US7967835May 5, 2003Jun 28, 2011Tyco Healthcare Group LpApparatus for use in fascial cleft surgery for opening an anatomic space
US8003156May 4, 2006Aug 23, 2011Advanced Cardiovascular Systems, Inc.Rotatable support elements for stents
US8017237Jun 23, 2006Sep 13, 2011Abbott Cardiovascular Systems, Inc.Nanoshells on polymers
US8048087Oct 15, 2007Nov 1, 2011Tyco Healthcare Group LpApparatus for use in fascial cleft surgery for opening an anatomic space
US8048089Mar 29, 2006Nov 1, 2011Edge Systems CorporationApparatus and methods for treating the skin
US8048441Jun 25, 2007Nov 1, 2011Abbott Cardiovascular Systems, Inc.Nanobead releasing medical devices
US8048448Jun 15, 2006Nov 1, 2011Abbott Cardiovascular Systems Inc.Nanoshells for drug delivery
US8052749Sep 20, 2005Nov 8, 2011Sadra Medical, Inc.Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US8066716May 3, 2006Nov 29, 2011Axia Medsciences, LlcInstruments and techniques for controlled removal of epidermal layers
US8147510Mar 11, 2010Apr 3, 2012Boston Scientific Scimed, Inc.Implant system and method for bulking tissue
US8182528Dec 23, 2003May 22, 2012Sadra Medical, Inc.Locking heart valve anchor
US8192452May 14, 2010Jun 5, 2012Tyco Healthcare Group LpEasily cleaned atherectomy catheters and methods of use
US8197879Jan 16, 2007Jun 12, 2012Advanced Cardiovascular Systems, Inc.Method for selectively coating surfaces of a stent
US8216209May 31, 2007Jul 10, 2012Abbott Cardiovascular Systems Inc.Method and apparatus for delivering an agent to a kidney
US8221112Apr 21, 2011Jul 17, 2012Abbott Cardiovascular Systems, Inc.Method for retaining a vascular stent on a catheter
US8226674Apr 9, 2010Jul 24, 2012Tyco Healthcare Group LpDebulking catheters and methods
US8231670Nov 3, 2008Jul 31, 2012Sadra Medical, Inc.Repositionable heart valve and method
US8236008Feb 29, 2008Aug 7, 2012Envy Medical, Inc.Microdermabrasion treatment heads
US8246640May 18, 2006Aug 21, 2012Tyco Healthcare Group LpMethods and devices for cutting tissue at a vascular location
US8246678Mar 9, 2007Aug 21, 2012Sadra Medicl, Inc.Methods and apparatus for endovascularly replacing a patient's heart valve
US8251918Jun 14, 2010Aug 28, 2012Daniel LarkinMethod and apparatus for simultaneously collecting exocervical and endocervical samples
US8251945Feb 26, 2007Aug 28, 2012U.S. Endoscopy Group, Inc.Endoscopic suction device
US8252052Feb 8, 2008Aug 28, 2012Sadra Medical, Inc.Methods and apparatus for endovascularly replacing a patient's heart valve
US8277287Nov 2, 2010Oct 2, 2012Dermasweep, Inc.Skin treatment system
US8293367Jul 15, 2011Oct 23, 2012Advanced Cardiovascular Systems, Inc.Nanoshells on polymers
US8328829Nov 2, 2007Dec 11, 2012Covidien LpHigh capacity debulking catheter with razor edge cutting window
US8328868Oct 13, 2009Dec 11, 2012Sadra Medical, Inc.Medical devices and delivery systems for delivering medical devices
US8337513Apr 24, 2007Dec 25, 2012Axia Medsciences, LlcInstruments and techniques for controlled removal of epidermal layers
US8343116Dec 30, 2008Jan 1, 2013Edge Systems CorporationApparatus and method for treating the skin
US8343213Oct 21, 2004Jan 1, 2013Sadra Medical, Inc.Leaflet engagement elements and methods for use thereof
US8364237Feb 26, 2010Jan 29, 2013Vessix Vascular, Inc.Tuned RF energy for selective treatment of atheroma and other target tissues and/or structures
US8396548Nov 11, 2009Mar 12, 2013Vessix Vascular, Inc.Selective drug delivery in a lumen
US8401667Nov 12, 2009Mar 19, 2013Vessix Vascular, Inc.Selective accumulation of energy with or without knowledge of tissue topography
US8414604Oct 13, 2009Apr 9, 2013Covidien LpDevices and methods for manipulating a catheter shaft
US8439847 *Jun 14, 2010May 14, 2013Daniel LarkinMethod and apparatus for simultaneously collecting exocervical and endocervical samples
US8465789Jul 18, 2011Jun 18, 2013Advanced Cardiovascular Systems, Inc.Rotatable support elements for stents
US8469979Sep 22, 2011Jun 25, 2013Covidien LpHigh capacity debulking catheter with distal driven cutting wheel
US8475518Jul 11, 2007Jul 2, 2013Advanced Cardiovascular Systems, Inc.Stent with anchors to prevent vulnerable plaque rupture during deployment
US8496615Apr 13, 2012Jul 30, 2013Abbott Cardiovascular Systems, Inc.Method and apparatus for delivering an agent to a kidney
US8496653Apr 23, 2008Jul 30, 2013Boston Scientific Scimed, Inc.Thrombus removal
US8496677Dec 2, 2010Jul 30, 2013Covidien LpMethods and devices for cutting tissue
US8523887Feb 11, 2010Sep 3, 2013Jeffrey GrayzelStiffened balloon apparatus with increased flexibility
US8551096May 11, 2010Oct 8, 2013Boston Scientific Scimed, Inc.Directional delivery of energy and bioactives
US8574249May 1, 2012Nov 5, 2013Covidien LpEasily cleaned atherectomy catheters and methods of use
US8579926Nov 28, 2011Nov 12, 2013Covidien LpPlaque removal device with rotatable cutting element
US8579962Dec 20, 2005Nov 12, 2013Sadra Medical, Inc.Methods and apparatus for performing valvuloplasty
US8592036Sep 20, 2012Nov 26, 2013Abbott Cardiovascular Systems Inc.Nanoshells on polymers
US8596215Jul 18, 2011Dec 3, 2013Advanced Cardiovascular Systems, Inc.Rotatable support elements for stents
US8597315Jul 1, 2010Dec 3, 2013Covidien LpAtherectomy catheter with first and second imaging devices
US8603160Dec 23, 2003Dec 10, 2013Sadra Medical, Inc.Method of using a retrievable heart valve anchor with a sheath
US8603530Jun 14, 2006Dec 10, 2013Abbott Cardiovascular Systems Inc.Nanoshell therapy
US8617236Nov 2, 2011Dec 31, 2013Sadra Medical, Inc.Medical devices and delivery systems for delivering medical devices
US8623076Sep 22, 2011Jan 7, 2014Sadra Medical, Inc.Low profile heart valve and delivery system
US8623078Jun 8, 2011Jan 7, 2014Sadra Medical, Inc.Replacement valve and anchor
US8637110Jul 18, 2011Jan 28, 2014Advanced Cardiovascular Systems, Inc.Rotatable support elements for stents
US8668733Nov 12, 2008Mar 11, 2014Sadra Medical, Inc.Everting heart valve
US8672990May 27, 2005Mar 18, 2014Boston Scientific Scimed, Inc.Fiber mesh controlled expansion balloon catheter
US8696640 *Jan 10, 2011Apr 15, 2014Russell ChurchillSnake venom evacuation and medication injection device
US8721662May 31, 2011May 13, 2014Envy Medical, Inc.Skin treatment system and method of use
US8741379Jul 18, 2011Jun 3, 2014Advanced Cardiovascular Systems, Inc.Rotatable support elements for stents
US8747439Jul 10, 2006Jun 10, 2014P Tech, LlcMethod of using ultrasonic vibration to secure body tissue with fastening element
US20070162107Mar 9, 2007Jul 12, 2007Sadra Medical, Inc.Methods and apparatus for endovascularly replacing a patient's heart valve
US20100249649 *Jun 14, 2010Sep 30, 2010Daniel LarkinMethod and apparatus for simultaneously collecting exocervical and endocervical samples
US20110125247 *Feb 7, 2011May 26, 2011Angioscore, Inc.Balloon catheter with non-deployable stent
US20120179092 *Jan 10, 2011Jul 12, 2012Russell ChurchillSnake Venom Evacuation and Medication Injection Device
US20120245616 *Jun 5, 2012Sep 27, 2012Farnan Robert CBalloon Catheter With Non-Deployable Stent
USRE42960Nov 9, 2000Nov 22, 2011Altair Instruments, Inc.Microdermabrasion device
CN100479765CApr 2, 2007Apr 22, 2009张西英Sampling apparatus for preventing cavitary cancer
DE1160980B *Jan 5, 1961Jan 9, 1964Wallace Beresford ShuteChirurgisches Instrument
EP0763345A1 *Sep 10, 1996Mar 19, 1997VANCE PRODUCTS INCORPORATED d/b/a COOK UROLOGICAL INCORPORATEDUterine endometrial tissue sample brush
EP1409063A1 *Jul 3, 2002Apr 21, 2004Syntheon, LLC.Methods and apparatus for sclerosing the wall of a varicose vein
WO1985000100A1 *May 30, 1984Jan 17, 1985Project UImproved endometrial cytologic sampling apparatus and method
WO1993011824A1 *Dec 9, 1992Jun 24, 1993James Z CinbergMethod and surgical instrument for repairing internal organ
WO1994023787A1 *Apr 21, 1994Oct 27, 1994David H RammlerSampling balloon catheter
WO1999044513A2 *Feb 22, 1999Sep 10, 1999Scimed Life Systems IncExpandable atherectomy burr
WO2002094108A2 *May 20, 2002Nov 28, 2002Univ LondonA flexible device for transfixing and joining tissue
WO2011096903A1Feb 4, 2010Aug 11, 2011Mahmut TokurCatheter device used in the treatment of heart and large vein injuries
WO2013116560A1 *Jan 31, 2013Aug 8, 2013The Trustees Of Columbia University In The City Of New YorkTissue sampling devices, methods, and systems
Classifications
U.S. Classification600/569, 15/104.33, 606/192, 600/570, 73/864.33, 604/103, 600/562, 446/197, 73/864.41
International ClassificationA61M23/00, A61M29/02, A61B10/00, A61B17/32, A61B10/02
Cooperative ClassificationA61M2025/1084, A61M2025/1086, A61B2017/320004, A61M29/02, A61B2010/0216, A61B10/02
European ClassificationA61B10/02