Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.


  1. Advanced Patent Search
Publication numberUS2731490 A
Publication typeGrant
Publication dateJan 17, 1956
Filing dateJan 28, 1953
Priority dateJan 28, 1953
Publication numberUS 2731490 A, US 2731490A, US-A-2731490, US2731490 A, US2731490A
InventorsBarsky George
Original AssigneeBarsky George
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Method of making cyanohydrins
US 2731490 A
Previous page
Next page
Description  (OCR text may contain errors)

Jan. 17, 1956 c. BARSKY METHOD OF MAKING CYANOHYDRINS Filed Jan. 28, 1953 INVENTOR. GE ORGE BARSKY A TTORNE Y United States Patent Mnrnon or MAKING CYANOHYDRINS George Barsky, New York, N. Y. Application January as, 1953, Serial No. 333,803

Claims. c1. zen-465.6

The present invention is directed to the production of cyanohydrins and more particularly to a continuous method having high eificiency. p

It is well known that aldehy-des and ketones reactwith hydrocyanic acid to form cyanohydrins according to the following equations.

R.R'CO+HCN R.R'C(OH)CN RCHO-l-HCN RCH (CH) CN wherein R and R are hydrocarbon radicals.

The reaction is one that comes to an equilibrium and even if exact combining weights of reactants are used,

there is also present in the final mixture some uncom For example, in the prior art acetone cyanohydrin has been manufactured by taking 96% liquid hydrocyanic acid, cooling, adding a small amount of alkali or sodium cyanide solution in water and then adding acetone under agitation with cooling. When the acetone has all been added, the mixture .was agitated for a while at the low temperature and then acidified with dilute aqueous hydrochloric acid. After this it was allowed to warm up to room temperature and the. free acetone and HCN removed by blowing with air or by heating under vacuum. Because of the acid condition, dissociation of the cyanohydrin did not occur. The yield was less than about In order to get superior raw material yield, it wasnecessary to recover the free reactants, separately, and re-use them in the process, which was a relatively costly operation; even then the overall yield was far from theoretical.

The preparation of liquid HCN is expensive. If sodium cyanide and acid are used, raw material costs are high. If HCN is made from natural gas and. ammonia, for example, by the method of Andrussow, described in U.'S. Patent No. 1,934,838, raw material and production costs are low, but recovery of liquid HCN from the dilute gas adds a substantial item of expense. In any case, the preparation, storage and handling of liquid HCN is hazardous and requires an expensive refrigeration system.

The present invention is intended and adapted to overcome the difficulties and disadvantages inherent in prior methods, it being among the objects of the present inven tion to provide a simple and safe method adaptable for continuous operation of forming cyanohydrins using hydrocyanic acid gas.

It is also among the objects of the present invention to utilize a cheapsource of HCN which is dilute, and obtain a full recovery of cyanohydrins by the use thereof.

actant which is an aldehyde or a ketone.

In practicing the present invention there is provided a continuous system consisting of a set of three zones in vertical arrangement and usually contained in a single tower provided with sets of bubble caps throughout the length thereof. In the lowermost zone, the cyanohydrin is recovered and at the same time any excess of HCN,

aldehyde or ketone is removed therefrom. The intermediate zone constitutes the zone of reaction, wherein gaseous HCN is reacted with a ketone or aldehyde with cooling to prevent volatilization of the reactants. The

; uncombined HCN passes into the uppermost zone where it meets a stream of cold water containing alkali, causing the HCN to be absorbed as alkali metal cyanide and the residual gases are allowed to flow out of the top of the tower.

The invention allows the use of dilute HCN gas such as W an 8% mixture obtained in the process referred to above without concentration and without conversion to liquid HCN. In order to avoid the reaction of the cyanohydrin with ammonia, I remove the free ammonia which is present in the HCN gas in unreacted form. This is very easily done by scrubbing with sulfuric acid whereby a valuable by-product, sulfate of ammonia, is obtained.

In the accompanying drawing constituting a part hereof and in which like reference characters indicate like Fig. 1 is a front elevational view diagrammatic in character, showing .a tower with suitable equipment for prac ticing the present invention, some parts being shown in section, and

Fig. 2 is a horizontal cross-sectional view taken along line 2-2 of Fig. 1.

The apparatus consists of a vertical tower, one usually circular in cross-section and having a series of horizontal plates 2 spaced apart and extending for practically the entire height of the tower. Each of the plates is provided with a bubble cap 3, an overflow pipe 4 and a dam 5 whereby a body of liquid is heldon each of the plates. The showing is diagrammatic and this type of bubble cap tower is well known.

Through the bottom of tower 1 extends a pipe 6 for the entrance of HCN gas, the pipe terminating in a head 7 having a series of openings at the upper face thereof to divide the gas into fine streams. Heating coils 8 are pro vided below the liquid level in zone A and a trap 9 is provided to maintain a constant level of liquid with overflow of product as it is formed. a

.At the top of zone B there is an inlet 10 for the re- A series of coils 11 are provided between the plates of the zone for the purpose of providing cooling means to absorb the heat of the reaction. At the bottom of zone B is a duct 12 for the entrance of an acid for the purpose of neutralizing the alkali in the reacted mass.

The uppermost zone C has a pipe 13 entering the top thereof, terminating in a head 14 having a series of openings in the lower face thereof for spraying Water into the top of the tower. Cooling coils 15 are provided in zone C and at the top thereof is an outlet 16 for waste gas.

In the operation of the process, a solution of alkali is introduced through pipe 13 into zone C, which is cooled moderately and usually below ordinary room temperatures by cooling coils 15. The carbonyl compound is introduced at 10, dissolving in the solution. which passes downwardly over successive plates whereit' meets and contacts with the HCN gas passing upwardly. A reaction takes place forming the cyanohydrin and the heat of reaction is removed by cooling coils 11. The reaction mixture then passes out of zone B and into zone A, there being added thereto sufiicient amount of an acid intro duced through inlet 12, to render the mixture acid and thus prevent hydrolysis of the cyanohydrin.

removed from the aqueous solution of cyanohydrin with out dissociation of the cyanohydrin which is stabilized by the acid conditions. This is accomplished by the sweepingaction of the inert gas, the temperature being high enough to prevent the absorption of HCN. V

In zoneB, HCN is absorbed from the dilute gas and dissolved in the Water present. The cooling helps the absorption and the absorbed HCN reacts with the car bonyl compound to form the cyanohydrin. As a result of this removal of HCN from solution by reaction, more HCN is dissolved and so HCN is rapidly and continuously removed from the dilute gas stream. This may be represented by the series of equilibria shown below:

Hcnsrrcnancn gas soln combined The net elfect is displacement to the right. The cooling also removes any heat generated by the reaction. In

addition, there is condensation or absorption of the carbonyl compound vaporized by the passage of gas through warm zone A.

Zone C serves to catch small amounts of HCN that may have been carried out of zone B by the inert gas.

This'is accomplished by the scrubbing action of cold water containing small amounts of'alkali. This alkali serves a double purpose; it absorbs HCN from the gas and it Considerable variation in the details may be made within the scope of the invention. For instance, the temperaserves as catalyst in zone B to promote the formation of cyanohydrin. If the carbonyl compound issomewhat volatile it also will be scrubbed out by the cold water.

The following is a specific example of the operation of the present invention:

By means of heating coil 8 the temperature in zone A is maintained at about 80 C. By coolingcoils 11, the temperature in-zone B is maintained at 25-30 C, In zone C by cooling coils 15, a temperature of 1 to 4 C. is maintained.

There is introduced through pipe 6 a dilute HCN containing about 8% thereof in a mixture of various gases and free from ammonia. Through pipe 13 there is introduceda aqueous solution of sodium hydroxide having a pH of 8.5 to 9.0. Acetone is introduced at 10in an amount which is equimolecular with respect to the HCN. The reaction therebetween takes place and the cooling by coils 11 is adjusted so as to maintain the desired temperature therein.

At 12 there is introduced a 50% aqueous acetic acid in an amount sufiicient to give a pH of about 3.0. The pH may be tested by any suitable means, such as paper, impregnated with methyl red or by any other suitable color method. In order to check on the equimolecnlar proportions of. acetone and HCN, provision is made at the upper part of zone A to withdraw a sample from time to time. Thesample is analyzed and the flow of acetone or HCN, or both, are adjustedto give the desired proportions. r

In the present invention a number of aldehydes and ketones may be used, such compounds being liquid at ture in the three zones may vary substantially, depending upon various factors and the temperature in zone A may range from about 65 to 100 C. In zone B the temperature may vary between about 25 and 60 C. In zone C the temperature may vary from 0 to about 20 C. Similarly the pH in the several zones may vary within relatively wide limits. In zone A the pH may range from 2.0 to 5.0 and in zones B and C, the pH may vary from V Various acids may be used for bringing the pH to the acid side, it being important that the acid be non-volatile under the conditions used and non-reactive with respect to the constituents. Among such acids are sulfuric, oxalic and phosphoric. The concentration of the HCN gas may vary within wide limits, and although usually the HCN content is from 5% to l0%, it may vary from 2% and up to 60% 1 I claim:

l. A continuous method of making cyanohydrins which comprises" passing a gas containing HCN upwardly through successive zones of reaction, introducing aqueous alkali solution into the uppermost zone and causing the same to fiow downwards, introducing into the intermediate zone a liquid carbonyl substance taken from the class consisting of aldehydes and ketones, and introducing into the lowermost zone an acid sufiicient in amount to provide a 7 pH less than 7.

absorption of HCN in the liquid therein.

3. A method according to claim 1 in which said uppermost zone is at a moderate temperature and said interroom temperatures and having from 1 to 5 carbon atoms.

Among the V mediate zone is cooled to absorb heat of reaction.

4. A method according to claim 1 in which the temperature in the lowest zone is sufiiciently high to prevent absorption of HCN in the liquid therein to cause volatili- 7. A method according to claim 1 in which'the amount.

of HCN in said gas is not over 10%. v

8; A method according to claim 1 in which the HCN is freed from ammonia before being introduced into said zones.

9. A method according to claim 1 in which said zones are vertically arranged in a tower. v

10. method according to claim 1 in which said zones are vertically arranged in a tower and each zone consists of a plurality of sections holding liquid through which said gas passes.

References Cited in the file of this patent UNITED STATES PATENTS 1,984,415 Macallum Dec. 18, 1934 2,090,942 Fick Aug. 24, 1937 2,101,823 Dittman Dec. 7, 1937 7 2,537,814 -Davis .Ian.:9, 1951 I FOREIGN PATENTS 250,899 Switzerland 0..-.-. Feb. 2, 1948

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US1984415 *May 26, 1933Dec 18, 1934Du PontPreparation of cyanhydrins
US2090942 *Mar 13, 1936Aug 24, 1937Ig Farbenindustrie AgProcess for the production of cyanhydrins
US2101823 *Apr 17, 1934Dec 7, 1937Du PontProcess of preparing cyanhydrins
US2537814 *Jan 14, 1949Jan 9, 1951American Cyanamid CoPreparation of acetone cyanohydrin
CH250899A * Title not available
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US2826601 *Feb 5, 1957Mar 11, 1958Carbogen CorpSystem for producing cyanohydrins
US2868828 *Nov 19, 1956Jan 13, 1959Goodrich Co B FMethod of removing lactonitrile from aqueous mixtures
US3607010 *Feb 17, 1969Sep 21, 1971Brown Lloyd LChemical exchange method of concentrating carbon isotopes
US3700718 *Nov 24, 1969Oct 24, 1972Sumitomo Chemical CoMethod for continuous production of pure acetone cyanohydrin
US3742016 *Oct 20, 1970Jun 26, 1973Mitsubishi Rayon CoProduction and purification of acetone cyanohydrin by multiple stage distillation and condensation steps
US4517132 *Jun 29, 1983May 14, 1985Union Carbide CorporationFrom metal cyanide and hydrochloric acid
US5187301 *Oct 11, 1990Feb 16, 1993W. R. Grace & Co.-Conn.Reacting glyconitrile with ammonia or ammonium salt
US5208363 *May 5, 1992May 4, 1993The Dow Chemical CompanyAminoacetonitriles
U.S. Classification558/351
Cooperative ClassificationC07C255/00
European ClassificationC07C255/00