|Publication number||US2752918 A|
|Publication date||Jul 3, 1956|
|Filing date||May 1, 1952|
|Priority date||Aug 17, 1949|
|Also published as||DE902776C|
|Publication number||US 2752918 A, US 2752918A, US-A-2752918, US2752918 A, US2752918A|
|Inventors||Uytenbogaar Johannes W Huybert|
|Original Assignee||Auguste Rooseboom|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (5), Referenced by (105), Classifications (17)|
|External Links: USPTO, USPTO Assignment, Espacenet|
5 Sheets-Sheet 1 INVENTOR. yfmggaarf III'IIIIIIIII TTORNEYS July 3, 1956 J. w. H. UYTENBOGAART HYPODERMIC INJECTION APPARATUS Filed May l, 1952 I 1 I l p l l l l n I uw n July 3, 1956 J. w. H. UYTENBOGAART 2,752,918
HYPODERMIC INJECTION APPARATUS 3 Sheets-Sheet 2 Filed May l, 1952 INVENToR.
- July 3, 1956 J. w. H. UYTENBOGAART 2,752,918
HYPODERMIC INJECTION APPARATUS 3 Sheets-Shea 3 Filed May l, 1952 I N VEN TOR um /f/l @fin/@duri 712/@ MM w Y.;
QQ E m2 Mi Nr V nted States Patent O HYPODERMIC INJECTION APPARATUS Johannes Wilhelmus Huybert Uytenbogaart, Wassenaar, Netherlands, assignor to Auguste Rooseboom, New York, N. Y.
Application May 1, 1952, Serial No. 285,389
16 Claims. (Cl. 128-218) This invention relates toa structurally and functionally improved hypodermic syringe and ampule -assembly.
The present application is a continuation-in-part of my prior application for United States Letters Patent on an automatically operated hypodermic syringe filed in the Patent O'ice on August 17, 1949, and identified under serial number 110,776, now abandoned.
It is a primary object of the invention to furnish an assembly of this nature which will embody a novel structure such that in response to a manual release or tiring of the mechanism the epidermis will be penetrated by a needle, medicament will be injected through the bore of that needle and the needle will be automatically withdrawn in a highly desirable and improved manner.
A further object is that of designing a hypodermic syringe which may be readily loaded with or receive an ampule filled with proper medicament and in which the mechanism of the syringe may be easily potentialized to perform the desired sequence of operations as afore outlined.
An additional object is that of providing an apparatus of this nature which will include relatively few parts each individually simple and rugged in construction and capable of ready assemblage to furnish a unitary apparatus operating over long periods of time with freedom from all diiculties. j
With these and other objects in mind, reference is had to the attached sheets of drawings illustrating practical embodiments of the invention and in which:
Fig. 1 is a sectional side view of the apparatus and showing the same in completely assembled condition;
Fig. 2 is a similar view with the `cap removed and the parts `projected to effect needle-penetration;
Fig. 3 is a fragmentary sectional view similar to Figs. l and 2 but showing the mechanism atsubstantially the completion of the injection stroke;
Figs. 4 and 5 are fragmentary side elevations showing exterior casing portions indexed substantially 90 with respect to each other;
Figs. 6 and 7 are transverse sectional views taken along the lines 6-6 and 7-7 respectivelyeand in thedirection of the arrows as indicated in Fig. 1;
Fig. 8 is a sectional side View of an ampule unit such as may be employed in this assembly;
Fig. 9 is a view similar to Fig. 1 but showing an alternative form of structure;
Fig. 10 is a sectional side view similar to Figs. `l and 9 but showing a still further form ofassembly;
Fig. l1 also corresponds to Figs. 1, 9 and l0 but nis illustrative of an additional alternative, and
Figs. 12 to 15 inclusive are sectional side views of ampules involving alternative designs.
Primarily referring to Fig. l, there is indicated at 2l) a housing cap which encloses a nose piece 21 and may have screw threaded connection as at 22 with a sleeve 23. The latter mounts the nose piece 21 again by way of example through screw threads. The' rear end `of sleeve 23 encloses a body 24 which is secured against 2,752,918 Patented July 3, 1956 ice 2 movement with respect thereto by, for example, a set screw 25 and any additional or auxiliary securing means which may be desirable.
Nose piece 21 is conveniently formed adjacent its outer end with a centrally disposed recess 26. Extending forwardly into the latter is a hypodermic needle 27, the body of which is normally housed within the nose piece 21 and sleeve 23. The rear end of this needle is secured to a hub 28 which is in turn mounted on the forward end of a stem 29. That stem is bored as indicated at 30 and this passage preferably communicates and is aligned with the bore of cannula 27. Stem 291 is conveniently notched as at 31. In line therewith, it is encircled by a plate 32 spring pressed as at 33 and terminating in an actuating portion 34 the outer surface of which is conveniently roughened or serrated. It is apparent that when the parts are in their normal position as shown in Fig. l, plate 32 riding within a slot formed in body `24 will bear against the side of notch 31 and thus prevent any axial movement of stem 29 with respect to sleeve 23.
A second sleeve 34 is disposed to the rear of sleeve 23 and connected thereto in a manner hereinafter described to provide a casing. This sleeve 34 has its end closed and is provided with a spring 3.5 which has its rear end bearing against that closed portion and its forward end acting against the forward liange of a chuck or ampule-receiving member 36. That member `has its rear end preferably constricted as at 37 to provide a guiding portion for engagement with the surface of the ampule. The chuck is formed with openings across which e an annular series of springs 39 extend. These springs carry at their outer ends pawls 40. As shown in Fig. l, they engage to the rear of bead 41 formed at the forward end of an ampule 42. The latter has its rear end closed. It contains medicament and its forward end is obstructed by a piston type stopper 43..
This stopper is provided with a bore 44 and its outer face may be formed `with a seat to receive the reduced end portion of stem 29 with the bore 36) of the latter aligning with the bore or opening 44 of the stopper. Adjacent the reduced rear end of stem 29 a plunger portion 45 is mounted. This plunger portion may' be formed with longitudinally extending slots pivotally mounting as at 46 a plurality of dogs 47. `The latter normally occupy positions at which they extend beyond the surface of the plunger head 45 by means of springs (not shown).
A spring 48 encircles stern 29 and has its opposite ends bearing against the opposed faces of plunger head 45 and body 24. Extending from that body and conveniently integral therewith, is a tube 49. This tube is concentrically disposed with respect to stem 29 and denes a space such that plunger head 45 may be accommodated within its bore. So accommodated, dogs 47 will cam against the rear edge of tube 49 and be swung to retracted position where their outer edges are substantially co-extensive with the `adjacent surfaces of plunger head 45. The resistance value of spring 48 is substantially less than that of spring 35. It is to be understood that the expansive force exertable by the latter is suiiicient to project the chuck 36 and the parts associated therewith to a point adjacent theI rear wall or face of body 24 and to fully compress spring 48.
A collar 51 connects sleeves 23 and 34. This collar has an internal diameter such that it may accommodate the adjacent `ends of such sleeves. Body 24 may abut an inwardly extending flange 52 forming a part of the collar. As previously brought out, this body portion is retained against movement with respect to sleeve 23 by securing elements such as 25. The collar is formed with any desirable number of spirally extending slots 53 and 54 to accommodate a corresponding number of these securing ele ments. In order to avoid unnecessary complication in the illustration in Figs. 4 and 5, only a single pair ofthese slots have been shown. As will be noted, they are opposed to each other and slot 53 extends through to the edge of collar 51. The forward edge of sleeve 34 presents an outwardly beveled surface as at S5. Rearwardly of that edge, this sleeve mounts one or more securing elements 56 as afore stated. As shown especially in Fig. 5 this securing element rides within slot 54.
Thus, it is obvious that by rotating the collar from the position shown in Fig. 4 to a position at which the securing element or bolt 25 is in line with the outer end of slot 53, casing section or sleeve 34 may be detached from sleeve 23. Under these circumstances, collar 51 will remain attached to the former sleeve. Conversely, if securing element 25 is aligned with the open end of slot or slots 53 and collar 51 is rotated in a reverse direction, the pin or bolts 25 and 56 will cam against the edges of the slots to draw the sleeves towards each other. This action will continue until sleeve 23 and the parts associated therewith are telescoped to a maximum extent within collar 51. Under those conditions, ange 52 will lie adjacent the rear face of body 24. The beveled edge 55 of sleeve 34 will be spaced from that ange. With cap 20 enclosing nose piece 21 the rear edge of the former will intervene the sleeve 23 and the extended actuating portion 34 of latch 32. Therefore, that latch may not be released to bring its opening to a position at which stem 29 may pass therethrough. Therefore, stern 29 will be retained against movement with respect to the parts therein.
Considering the operation of this mechanism, it will be assumed that the parts thereof are assembled and in the positions shown in Fig. l and that ampule 42 is filled with medicament. If now cap 20 is removed from the sleeve 23, nose piece 21 will be exposed and the recess 26 of the latter can be disposed above the surface of the tissue to be injected. With removal of the cap, the latch may be released. This is achieved by pressing against the actuator portion 34 to shift the plate 32 to a position at which its orifice is concentrically disposed with respect to the surface of stem 29. Under these circumstances, spring 35 which is under compression will be free to function as a power means and expand because of the release of restraint against stem 29.
As spring 35 expands it will shift chuck 36 to the left as viewed in Fig. l. This will be because the forward end of the spring bears against ange portion 38 of the chuck 36. The latter together with the contained ampule will move in unison because the inner ends of pawls 40 bear against bead 41 of the ampule by reason of the inward pressure exerted by springs 39 extending through the slots in the forward end of the chuck assembly. The pressure exerted by spring 35 will also be transmitted to stem 29 because of the dogs 47 which bear against the forward edge of the ampule. It follows that cannula 27 will be projected beyond the nose piece and with the parts properly proportioned that projection will result in a penetration of the tissues to the desired depth. This position of the parts has been shown in Fig. 2.
There has been illustrated in that view the fact that dogs 47 have cammed against the rear edge of tube 49 so that these elements are retracted with respect to the actuating head 45 and therefore no longer bear against the outer edge of the ampule. It will be incidentally noted that spring 48 has now been fully compressed incident to the shifting of the parts from the position shown in Fig. 1 to that illustrated in Fig. 2. In any event, with the ampule assembly free to move with respect to actuating head 45, the latter will cause piston stopper 43 to shift rearwardly within the ampule body. This will result in the liquid medicament within the ampule being expressed through bore 44 of stopper 43 and bore 30 of stem 29 as well as the bore of the cannula. The latter having reached its maximum depth of tissue-penetration, it follows that the medicament will be injected and this action of the parts will continue until piston stopper 43, under the urging of spring 35, reaches a position substantially fully retracted within the body of ampule 42. This has been shown in Fig. 3.
It will be observed in the latter figure that pawls 40 have ridden in contact with and beyond the bevelled edge portion 55 of the rear sleeve 34. Therefore they have moved outwardly under the action of springs 39. This will have caused the inner portion of the pawls to move from positions to the rear of bead 41 of the ampule. In other words, the clutch structure which has heretofore been operative to maintain the ampule in a forward position within the chuck will now become inoperative. Therefore, while the chuck assembly will remain in the projected position shown in Fig. 3, the stem 29 and ampule 42 as well as the parts included in these assemblies will under the urging of spring 48 move rearwardly. This rearward movement will continue until stem 29 has reached its fully retracted position. In such position the needle 27 will be completely withdrawn from the tissues. Also, latch plate 32 under the urging of spring 33 will have shifted to a point at which the notch 31 of the stem accommodates the adjacent plate portions. It follows that no further shifting of the stern and its associated parts will occur with respect to sleeve 23.
The operator by now turning collar 51 to a position at which the bolt or other projection 25 may be withdrawn from slot 53 will be able to separate sleeve 34 from sleeve 23. Under these circumstances, the chuck structure will be exposed so that the spent or discharged ampule may be withdrawn and discarded. A fresh ampule is now positioned within the chuck. With the latter shifted rearwardly so that the pawls 40 are beyond the bevelled surface 55, these pawls will engage to the rear of the ampule bead 41 as shown in Fig. 1. It is to be remembered that stem 29 is maintained in retracted position. Therefore, the operator in reassembling the parts will bring the actuating head 45 to a position in line with the piston stopper 43. So aligned dogs 47 will bear against bead 41 and by telescopically disposing sleeve 23 with respect to collar 51, stem 29 will force the chuck rearwardly to a position at which spring 35 is properly compressed. As the collar 51 is rotated through its final stages, to lock the parts, the camming action exerted by slots 53 and 54 will cause a slight retractive movement on the part of piston 43 until further shifting is arrested by the dogs 47 engaging bead 41. That slight movement will cause liquid medicament to pass through bores 44, 30 and the bore of the cannula so that air will be evacuated from these passages. With cap 20 again applied in position the relationship of the parts will be reestablished and the apparatus will be ready for a second operation.
As will be understood the specific configuration of the ampule might be varied in numerous particulars as might also its capacity. Preferably the parts of this assembly are properly sterilized and the medicament is placed within the body of the ampule in sufficient quantity to provide the desired dosage. Thereafter, the piston stopper 43 is disposed adjacent the open mouth of the ampule. The sterility of the parts is maintained by providing, for example a cap or protective layer 57 of any suitable material which overlies the face of stopper 43. `It is apparent that prior to placing the ampule in association with the chuck this protective strip or cap is removed and discarded. It will also be apparent that the ampule may be formed of any desired material such as glass and that the stopper thereof is preferably formed of a synthetic or natural rubber. Likewise the several parts of the injecting mechanism may be formed of any desired materials such as suitable metals and/ or plastics.
In Fig. 9 an apparatus has been illustrated which largely follows the structure shown in Figs. l to 7. For this reason, similar reference numerals have been used to designate corresponding parts. However, as will be seen in this figure, the structure of chuck 58 has been modified in comparison to the structure of chuck 36. More particularly, instead of being provided with longitudinally ex` tending openings through which springs 39 and pawls 40 extend, the chuck 58 is formed with an annular series of openings within which spheres 59 may be disposed. These openings may be constricted adjacent their inner ends to retain the balls. These spheres bear against the outer surface of the ampule and the inner bore surface of sleeve 34. The rear end of the stern 29 is tapered and reduced as indicated at 60 to extend through the enlarged bore of piston stopper 6l. ln advance of that stopper, a plate 62 is provided. This is formed with an opening of a diameter adequate to accommodate the reduced end portion of the stem. Therefore, when the stem has penetrated the stopper to the position shown in Fig. 9, further relative movement in a rearward direction is prevented. Also, in lieu of the actuating head 45 and series of dogs 47 a plurality of swinging spring arms or pawls 63 are provided to bear against the outer edge of the ampule.
As will be appreciated the operation of the parts is substantially identical with that heretofore described. Briefly summarized, the main spring will function as a power means to project the chuck and ampule carried thereby from the position shown in Fig. 9 to a position at which the needle has penetrated the tissues to the desired depth. At that moment spring arms 63 will cam against the rear edge of the tube into which spring 48 extends and be swung to retracted positions such that they may enter the tube. So retracted, the pressure of the main spring will be free to project the ampule with respect to stopper 61 which will cause an expulsion of the medicament. At the extreme of this stroke, the clutch structure provided by the spheres S9 will become inoperative because these spheres or balls will have overridden the bevelled edge 55. Therefore, the ampule will be disconnected from the main spring and incident to the action of spring 4S will shift rearwardly as a unit with stem 29 to cause a withdrawal ofthe needle from the injected tissues.
Now referring to the structure illustrated in Fig. l0, it will be seen that the numeral 64 indicates a nose piece to which a cap 65 may be applied. Pins or projections 66 are carried by collar 67; further slots in that collar cooperating with pins 68 extending from casing assembly 69. These slots are opposed to each other in the manner shown in Figs. 4 and 5 and have open end portions (similar to slot 53) extending through to the edges of the collar. In this manner, casing 69 is detachably coupled with the collar which is in turn detachably coupled to the nose piece. The forward edge of the casing 69 provides a bevelled surface 70 which is spaced from the adjacent rear face of the collar.
A chuck member 7l adjacent the rear end of casing 69 is formed with an outwardly extending flange portion 72. A cup-shaped member 73 isprovided with a forward bead or flange 74. This cup member has extending outwardly from its base a piston rod 75. A spring 76 is interposed between flange 72 of the chuck member and the rear end of casing 69. Flange 72 is formed with an annular series of perforations which receive a corresponding number of spheres or balls 77. As shown, these elements bear against the outer face of cup 73 and the inner face of casing 69, to also engage the bead 74. The openings are tapered in an inward direction so that inward movement of the spheres 77 is limited,
A slidable member preferably lembracing a` forward section 78, intermediate sections 79, 80 and V81 and a rear headed section terminating in` pawls 82, constitutes an ampule receiving chamber. This member might of course be made of a lesser number of sections. However, by providing a plurality of parts, the lengthof the bore defined may be varied to accommodate ampules of greater or lesser length. The slidable member is encircled by a tube`83 carried by nose piece 64. The forward section 78 of the slidable member conveniently presents a `transverse partition 84 provided with a passage 85 the area of which may be` varied by projecting and retracting a screw 86'f1`1nction-- ing as a valve. Extending from the inner face-'of parti-r tion 84 is a piercing needle 87. Extending from the opposite face of that partition is a mounting portion supporting the hub of a needle 83. The bores of needle 87, passage S5 and cannula 88 are preferably aligned.. In any event, they are in communication with each other.
In :common with the design of earlier structures it is preferred that the cap 65 embody a safety provision. To this end it underlies the` actuating portion 89 of a lever pivotally mounted as at 90 and furnished with a latch portion 91. The latter extends into a groove 92 formed in section 78. Also extending into this groove are onev or more pawl elements 93. It will be apparent that with cap 65 in position the actuating portion 89 may not be shifted against the action of its spring.. A spring 95 exerting less expansive force than spring .76 i's interposed` between the outer end of nose piece 64 and partition 84. Conveniently the inner face of the nose piece may :be recessed as at 96 to accommodate the end of the spring.
The ampule for use with an apparatus such'as has been shown in Fig. l0 has been illustrated in Fig. 15 and has its forward endengageable with the needle 87 as it is slipped into the receiving compartment. defined by the slidable member. Preferably and as shown the rear needle 87 may be encircled by a spring 97 offering a minor degree of resistance but nevertheless effective to urge cap 98, which has been penetrated, in a rearward direction to accordingly shift the body of the ampule 99. The latter has its rear end open and receives a piston type stopper 100. Adjacent its forward end the ampule is preferably constricted as indicated at X01. As shown the length of the ampule is such that it may be effectively housed within the slidable member with rod 75 in engagement with the rear face of piston stopper 100. As previously brought out, the parts may be reproportioned and the length of the slidable member may be changed to receive ampules having a lesser or greater length than that illustrated in Fig. l5.
Conveniently at the rear end of the syringe a safety catch is provided. As shown, this will prevent a forward or projecting movement on the part of the chuck assembly andthe mechanisms associated therewith. Such catch may take one of numerous different forms. As shown, `it embraces a knob 102 rotatably mounted adjacent the outer rear face of casing 69 and provided with a stem 103 extending through an opening in that rear wall and an opening in the adjacent wall of the cup-shaped member 73. Secured to its inner end is a cam 104 which rotates as a unit with the stem and enters through the latter opening. A detent structure may be provided by employing a spring 105 secured to the inner face of cap 102 and bearing into an opening 107 `formed in the end wall of the casing. When this spring thus bears, an accidental rotation of the parts will be prevented and the assembly engaged by cam 104 will be secured against movement. However,` by simply turning cap 102 the cam may be shifted to released position.
Assuming that such shiftinghas occurred and the parts are assembled in the manner shown in Fig. 10, then it will be appreciated that an operator may usethe apparatus by simply removing cap 65 and disposing the outer end of nose piece 64 in engagement with the epidermis `overlying the tissues to be injected. If now actuator 89 is rocked around its pivot 90, latch 91 will be released from groove 92. With such release slidable member 78-81 will be projected under the influence of the power means provided by spring 76. This will occur` because the spring is bearing against flange 72 and is `in a .compressed` condition. The clutch structure provided byl the balls or corresponding elements 77 willthrust againstcup member 73 and especially thebead portion 74 thereof. That bead portion being in line with pawls` 82, this thrust willrbe,
transmitted lto the latter. These ,pawlsformingl parts of` the sliding memberassembly, thatV memberrwillbe shifted to the left as kviewed ink Fig. 10. The initial phase of shifting will result in a projection of needle 88 so that the epidermis is pierced and with continued projection, the needle will penetrate the tissues to the desired depth.
Outward movement of the sliding member is of course arrested by the forward end of the same moving to a point in contact with the rear face of the outer wall of nose piece 64. During the projection of the sliding member, spring 95 will have been compressed. Simultaneously with the needle reaching its full depth of penetration, dogs 82 will have the cam portions adjacent their outer ends ride into engagement with the rear edge of tube 83. This will release the coupling between these dogs and the chuck assembly. Accordingly with the sliding member stationary and projected to a maximum extent, that chuck assembly may continue to move under the urging of spring 76.
With the chuck assembly free to move with respect to the sliding member it will carry with it rod 75, which acting'against piston 100, will shift the latter within the body of ampule 99 to thus express medicament through the bores of needles 87 and 88 and the intervening bore 85 of partition 84. The speed of injection of the medicament may of course have been regulated by, for example, the valve structure provided by screw threaded member 86 in cooperation with bore 85. This cooperation of the parts will continue untilsubstantially all medicament has been discharged.- Stopper 100 will have moved to a point adjacent the constriction 101 of the ampule and shiftedthe latter against the action of spring 97. At that instant flange 72 of the chuck assembly will have reached a point adjacent the central area of collar 67. Accordingly, the-spherical elements 77 will have ridden over edge 70. This will render inoperative the clutch structure between cup 73 and chuck 71. Therefore, under the inuence of spring 95 the slidable member will now be free to retract thereby withdrawing the needle from the tissues. In such retraction too great a movement of the nose piece will be prevented by the latch 91 and pawls 93 engaging the edge of groove 92.
With the completion of this sequence of operation collar 67 may be rotated to disconnect casing 69 from nose piece 64. Due to spring 97, no difficulty will be experienced in removing the spent ampule from the bore of the sliding member and replacing the same with a fresh ampule. By shifting flange 72 with respect to cup-shaped member 73 spheres 77 may be caused to again assume positions to the rear of bead `74. Therefore, as clogs 82 engage against the forward edge of cup member 73 they will cause the entire chuck assembly to move rearwardly within casing 69' to compress spring 76. This action will continue until pins 66 and 68 enter the bayonet or other slots provided as part of collar 67. As the latter is rotated around the axis of the assembly a camming action is set up such that the parts are drawn into proper positions. During this movement, it is apparent that rod 75 in engagement with piston 100 will cause a bodily shifting of the ampule, such that needle 87 will penetrate the closure 98 and spring 97 will be compressed. Due to the minor degree of resistance offered by the latter, such shifting and penetration will not cause a movement of the piston in the ampule body. During the final stages of turning of the collar 67 the piston will however be given a slight movement which will result in an expulsion of medicament through the bores of needles 87 and 88 and the intervening bore 84 so that all air will be voided.
In the structure shown in Fig. 11 a cap 108 is preferably employed to protect the nose pice 109. The latter encloses a spring 110 and has secured to it a sleeve 111. That sleeve is provided with a space to accommodate a slidably mounted latch plate 112 provided with an actuator 113. Preferably and in common with the earlier structures the extension 113 may bear against the cap 108 so that when the latter is in position, the latch may not be released against the tension of the spring associatedI with the same. Sleeve 111 is secured by, for example, bolts 114 to a body portion 115 which is in turn attached to a rearwardly extending casing 116. Interposed be. tween the body portion 115 and the sleeve is the end flange of a tube 117 which is thus held in position.
The latter slidably accommodates a bored member 118 Within which a unit 119 is secured. This is formed with a duct or bore 120 and provides at its outer end a mounting for the hub of a needle 121. Adjacent its inner end it mounts a piercing needle portion 122. The bore 120 is aligned with the bore of cannula 121 and 122. A valve structure controlling the flow of medicament through these bores is conveniently furnished by adjustably mounting a stem 123 on member 118 and having this stem extend through to bore 120.
Within the rear end of casing 116 a power means in the form of spring 123 is disposed. The expansive force of this spring is substantially greater than that of spring 110 and' may in fact be many times greater. This spring has its rear end bearing against the end wall of the casing and its forward end bears against a ring 124. A spring 125 is arranged in advance of ring 124 and embodies sufficient strength to maintain a sleeve 126 normally spaced therefrom in the manner shown in Fig. 1l. Sleeve 126 is conveniently formed with a recess 127 which may take the form of an annular depression in its inner face. A clutch assembly including an outer collar 128 and an inner cup-shaped member 129 is disposed within the rear end of the casing and provides a stem or rod 130 which bears against the piston stopper 131 of an ampule 132. The latter in common with the ampule shown in Fig. l5 preferably embraces a constricted portion 133 adjacent its forward end and the open mouth of that latter end is closed by a seal 134. The overall diameter of the ampule is such that it may be accommodated within the bore of slidable member 118 and have its forward end disposed near the rear end of unit 119.
Adjacent the rear end of slidable member 118 there are a series of dogs or pawls 135. These may be secured in any desired position and have their rear ends extending beyond the face of slidable member 118. To the rear of these dogs the slidable member may mount a retaining assembly 136. The latter terminates in an apertured member the opening of which has a diameter less than the diameter of ampule 132 but in excess of rod 130. Accordingly, the ampule will be retained in association with slidable member 118 when the assembly 136 is in position. Adjacent the body 115 and mounted preferably by the casing 116 are a series of stops 137. These extend into the path of travel of sleeve 126. It will finally be noted in connection with this portion of the assembly that balls 138 are disposed in an annular series of openings formed in the flange 139 of collar 128 and that cup 129 terminates in an outwardly extending flange 140 the diameter of which is such that it would be engaged by the rear end of pawls when the latter are in their normal position as shown.
Now considering the operation of the apparatus as described and shown in connection with Fig. 11, it will be understood that with the parts in the position illustrated and nose piece 109 exposed, the operatorv-after bringing that nose piece to the desired positionmay press against actuator 113 to thus align the aperture of the latter with respect to the slidable member 118. Accordingly, the latter is released for movement. Such movement will occur under the action of the power means or spring 123 pressing against ring 124 to shift the chuck assembly including the piston 130 to the left as viewed in this figure. The ampule 132 will be likewise shifted because of the engagement of pawls 135 with the forward bead of edge portion of cup 129. As needle 121 reaches its fully projected position, spring 110 will be fully compressed. 'Ihe rear ends of pawls 135 will enter tube 117 and thus be rocked inwardly. Incident to that movement, the
chuck assembly will be freed from exerting thrust against slidable member 118. With such freeing and under the action of spring 123, the chuck assembly will be projected with respect to the ampule thus causing piston stopper 131 to discharge medicament through the needle portion 122 and so through the bore of cannula 121.
This action will continue until sleeve 126 has reached a position in contact with stops 137. Simultaneously stopper 131 will engage constriction 133 to arrest movement of the chuck. Thereupon spring 123 will continue to urge and move ring 124 and member 128 with respect to sleeve 126. With that shifting the balls 138 or eqnivalent members will move into the recess 127. Therefore, they will be retracted from behind the flange 140. Accordingly the clutch structure will become inoperative to cause spring 123 to retain sliding member 118 in projected position. Under these circumstances spring 110 will shift that member together with needle 121 and the associated parts rearwardly. This will withdraw the hypodermic needle from the tissues after the completion of the injection stroke.
The couplings between the bolts providing the stops 137 and sleeve 111 may embrace bayonet slots 141 or slots which have openings terminating in the edge portion of one of the parts of the assembly. Of course other coupling means might be employed. In any event after the operation of the apparatus as afore described, casing 116 is detached from the parts associated with the nose piece. The spent ampule 132 is withdrawn by dismounting the outer element of the assembly 136. A new ampule is placed in position. The reestablishment of the clutch portions involving the chuck assembly, sleeve 126 and associated parts is reestablished by gravity, manually shifting the parts or otherwise in the same manner as in the case of the mechanism shown in the preceding gures. Now as the casing 116 is again connected to the nose piece the ends of pawls or dogs 135 will bear against a flange 140 of cup 129 and force the same rearwardly together with flange 139 of member `128. This will result in a similar movement on the `part of ring or collar 124. Accordingly, spring 123 will be compressed. This compression will continue until the nal, stages of tightening of the parts at which time piston rod 130 willproject piston stopper 131 to a slight degree, such that air within the bores of the cannula is vented and these bores are filled withliquid medicament., Y l
When the apparatus is 'not in use, sterilization of the parts may be maintained by introducing any. suitable quantity of liquid such as alcohol or suitable fluid vapor within the mechanisms. To this end and as shown especially in Figs. 1l and 9 enclosing caps or shields 142 may be applied. As afore brought out the ampule shown in Fig. 8 is primarily the type for employment inconnection with the mechanism shown in Figs. w1 to 3 inclusive. The ampule shown in Fig. 13 is ofthe type'primarily intended in use in connection with apparatus asshwn in Fig. 9. rThe ampule of Fig. 13 `corresponds to the `one shown in the assembly in Fig. 10 and by modifying the length of the same furnishes an ampule suitable for use in mechanisms such as are shown in Fig. l1.` The ampules illustrated in Figs. 12 and 14`exemp1ify-structures which are suitably modified according to the needs of the manufacturer but which will still achieve the functional results desired.
Thus among others the several objects of the invention as specifically afore noted are achieved. It will be understood that numerous changes in construction and rearrangement of the parts might be resorted to without departing from the spirit of the invention as defined by the claims.
1. A hypodermic injection apparatus including in combination a body, a support movably associated with said body to mount a hypodermic needle and medicament-containing member operatively connected with each other,
10 power means within said body and connected with said support'foreifecting a projection thereof, manually controlled means carried by saidbody for releasing said support for projection, a cap mounted by said body and said cap-when mountedobstructing said manual means to prevent such release.
2; A hypodermic syringe for automatically performing injections into human and animal bodies and designed for use with a removable rigid therapeutic-containing ampule, the combination comprising a casing, slidable ampule-carrying means in said casing, needle carrying means provided with a passage from an ampule to a needle carried thereby, therapeutic-expelling means slidably mounted relative to said ampule operable to expel therapeutic from said ampule through said needle, first spring means, means to energize andmeans to release said first spring means, second spring means engaging said needlecarrying means energizable by forward movement of said needle-carryingmeans, coupling means to connect automatically said first spring means with the ampule in its slidable ampule-carrying means, the needle-carrying means and the therapeutic-expelling means, so that when said rst spring means is released, the ampulecarrying means and needle-carrying means move in a forward stroke energizing said second spring means, the first part of said forward stroke being the needle-inserting stroke, automatic means to disengage at the end of said first part of said forward stroke, the needle-carrying means and to maintain it in its advanced position thereby maintaining the second spring means in energized condition, and to disengage from each other the ampule and its carrying means, the therapeutic-expelling means causing during the second part of the forward movement of said coupling means a relative displacement between said ampule in its carrying means and said therapeuticexpelling means so as to expel therapeutic through said needle, said second part of the forward movement of said coupling means constituting the injection stroke proper, automatic means to disengage at the end of said second part of the forward movement said needle-carrying means from said coupling means releasing thereby said second spring means so as to move backward said needle-carrying means, said movement constituting the needle-retracting stroke; said lirst spring means consisting of an axial coil spring resting with its rear end against the bottom of a barrel constituting the rear part of the syringe casing, and permanently engaging with its forward end the coupling means, the second spring means consisting of an axial coil spring less powerful than the first one and mounted in opposition thereto, said second spring resting with its forward end against the syringe head forming theremovable front part of said syringe casing, and permanently engaging the needle-carrying means with its rear end.
3. `A hypodermic syringe as in claim 2 wherein the coupling means to connect automatically the first spring with the ampule in its slidable carrying means, the needlecarrying means, the therapeutic carrying means and the second spring means, includes an annular chuck slidable in the `casing of the syringe and having inwardly protruding pawls located in corresponding radial holes of the chuck body, said pawls being urged in outward direction and resting against the inner cylindrical surface of said casing. i
4. A hypodermic syringe as in claim 2 having means to stop the chuck at the end of the stroke of the first coil spring consisting of an inwardly extending collar of the intermediate part.
5. A hypodermic syringe as in claim 2 and having a protective cap removably Xed onto the head of the syringe and engaging the releasing means so as to act as a safety catch to prevent the operation of the syringe when said cap is in position.
6. A hypodermic syringe as in claim 5 provided with a removable cap screw-threadedly mountable on the syringe barrel to enclose hermetically the mechanism.
7. A hypodermic syringe as in claim 2 for use with a rigid tubular ampule open at one end and having adjacent said end an external collar with a straight rear face, wherein the pawls adapted to engage the rear face of said collar are block shaped members slidable in radial holes of the chuck and provided with spring means urging themin outward direction.
8. A hypoderrnic syringe as in claim 3 having means arresting the forward movement of the needle-carrying means and the therapeutic-expelling means at the completion of the iirst part of the stroke of the first coil spring comprising a radial extension of the chuck adapted to abut against the rear face. 'fof the fixed tubular means.
9. A hypodermic syringegjas in claim 8 having therapeutic-expelling means, said means consisting of a piston `mounted at the rear end of the rearward tubular extension of the needle-carrying means adjacent the chuck with which said tubular extension is provided, said chuck having a diameter slightly less than the inner diameter ofthe ampule, said piston having an axial channel forming the prolongation of the channel of said tubular member.
10. A hypodermic syringe as in claim 9 having passage means for therapeutic from the ampule to the needle, said passage means consisting of a tube with a bevelled rear end, said tube extending in a rearward direction from the needle-carrying means so as to pierce the pierceable cap at the front end of the ampule and to penetrate into the ampule when the ampule is inserted into the ampule-carrying means.
ll. A hypodermic syringe as in claim l() having the coupling means engaged by the first coil spring comprising an annular chuck provided with an inwardly flanged sleeve-like extension slidably associated with a tubular member, and having adjacent its front end, an external collar releasably engageable by the pawls of the chuck carrying the therapeutic-expelling means, said pawls being urged in an outward direction against the inner surface of the casing and releasing said tubular member at the end of the forward stroke of the rst coil spring by moving into an annular recess in the casing.
12. A hypodermic syringe as in claim ll having means to arrest the forward movement of the needle-carrying means and of the ampule-carrying means comprising an external collar of the ampule carrying means located between its rear end and the pawls, said collar having its outer diameter greater than the inner diameter of the tubular means so as to abut against the rear face of said means at the end of the first part of the expanding stroke of the first coil spring.
13. A hypodermic syringe as in claim 2 for use with a rigid tubular ampule provided at its front end With a pierceable cap and at its rear end with a slidable piston, the syringe being provided with slidable ampule-carrying means having a rearward tubular extension of the needlecarrying means with passage means for therapeutic from the ampule to the needle including a tube with a bevelled rear end extending in a rearward direction from the needle-carrying means, said syringe further being provided with an annular chuck having an inwardly flanged sleeve-like extension slidably associated with a tubular member carrying the therapeutic-expelling means, said means consisting 'in a piston pusher projecting in forward direction from the bottom of said tubular member to engage the piston slidably associated with the ampule.
14. A hypodermic injection apparatus includingl in combination a casing having an open end, a needle-carrying member projectable within said casing towards the open endof the same, an ampule support, clutch means shiftable with and coupling said support to move in unison with said carrying member, a piston-shifting element to cause expulsion of liquid fro-m an ampule carried by said support, power means for projecting said support, element and needle-carrying member as a unit to cause a needle associated with the latter to be exposed beyond said casing, and means connecting said power means with said piston-'shifting element to thereupon cause relative movement between said ampule support and piston-shifting element.
l5. A hypodermic injection apparatus including in combination a casing having an open end, a needle-carrying member projectable within said casing towards the open end of the same, an ampule support, clutch means shiftable with and coupling said support to move in unison with said carrying member, a piston-shifting element to cause expulsion of liquid from an ampule carried by said support, power means for projecting said support, element and needle-carrying member as a unit to cause a needle associated with the latter to be exposed beyond said casing, means for thereupon arresting further movement of said ampule support and means connecting said power means to said piston-shifting element to thereafter move the latter with respect to said ampule support.
16. kA hypodermic injection apparatus including in combination a casing having an open end, a needle-carrying member projectable within said casing towards the open end of the same, an ampule support, clutch means shiftable with and coupling said support to move in unison with said carrying member, a piston-shifting element to cause expulsion of liquid from an ampule carried by said support, power means for projecting said support, element and needle-carrying member as a unit to cause a4 needle associated with the latter to be exposed beyond said casing, a spring arranged in opposition to said power means to be compressed during the projection of said needle-carrying member, means connecting said power means to cause relative movement between said ampule support and piston-shifting element upon said clutch means being rendered inoperative, means causing a release of said clutch means after the movement between said ampule support and piston-shifting element todisconnect the latter from said power means and said spring functioning finally to effect a retraction of said needlecarrying member.
References Cited in the le of this patent Germany July 30, 1923
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US159192 *||Jan 12, 1875||Jan 26, 1875||Improvement in hypodermic syringes|
|US2413303 *||Jan 17, 1944||Dec 31, 1946||Marvin L Folkman||Syringe|
|US2531267 *||Oct 16, 1947||Nov 21, 1950||Fritz Harnisch||Hypodermic syringe operating device|
|DE378714C *||Jul 30, 1923||Charles De Montet Dr||Selbsttaetiger Injektionsapparat|
|GB143084A *||Title not available|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US2871856 *||Sep 6, 1955||Feb 3, 1959||Astra Ab||Hypodermic syringe|
|US3055362 *||May 16, 1956||Sep 25, 1962||Auguste Rooseboom||Hypodermic injection apparatus|
|US3306290 *||Feb 14, 1964||Feb 28, 1967||Harold S Weltman||Automatically retractable needle syringe|
|US3314428 *||Dec 4, 1963||Apr 18, 1967||Johnson Alvin P||Veterinary hypodermic syringe|
|US3403679 *||Dec 10, 1965||Oct 1, 1968||Secr Defence Brit||Hypodermic injection apparatus with a secondary capsule-collapsing means|
|US3403680 *||Jun 13, 1966||Oct 1, 1968||Secr Defence Brit||Hypodermic injection apparatus|
|US3702609 *||Nov 19, 1969||Nov 14, 1972||Maurice Steiner||Hypodermic syringes, in particular self-injecting syringes|
|US3742948 *||Aug 10, 1970||Jul 3, 1973||Philips Corp||Hypodermic syringe with radially movable blocking elements|
|US3797489 *||Feb 10, 1972||Mar 19, 1974||Survival Technology||Hypodermic injection device with shock absorbing spring|
|US3880163 *||Oct 26, 1973||Apr 29, 1975||Jack H Ritterskamp||Medicinal syringe actuating device|
|US3882863 *||Aug 1, 1973||May 13, 1975||Survival Technology||Hypodermic injection device having cannula covered with resilient sheath|
|US4202314 *||Nov 20, 1978||May 13, 1980||Busygin Valery P||Device for injection of medicinal preparations|
|US4822340 *||Oct 9, 1986||Apr 18, 1989||Duphar International Research B.V.||Automatic injector|
|US4894054 *||Jun 20, 1988||Jan 16, 1990||Miskinyar Shir A||Preloaded automatic disposable syringe|
|US5137516 *||Nov 27, 1990||Aug 11, 1992||Glaxo Group Limited||Triggered application device for medicament to be more descriptive of the invention|
|US5188599 *||Feb 15, 1991||Feb 23, 1993||Med-Design, Inc.||Retractable needle system|
|US5295965 *||Aug 26, 1992||Mar 22, 1994||Survival Technology, Inc.||Automatic injectors|
|US5423758 *||Dec 16, 1993||Jun 13, 1995||Shaw; Thomas J.||Retractable fluid collection device|
|US5425715 *||Aug 5, 1993||Jun 20, 1995||Survival Technology, Inc.||Reloadable injector|
|US5478316 *||Feb 2, 1994||Dec 26, 1995||Becton, Dickinson And Company||Automatic self-injection device|
|US5593388 *||Nov 14, 1994||Jan 14, 1997||N.J. Phillips Pty. Limited||Injector with retractable shroud|
|US5658259 *||Oct 19, 1995||Aug 19, 1997||Meridian Medical Technologies, Inc.||Dental cartridge assembly auto-injector with protective needle cover|
|US5709662 *||Aug 23, 1996||Jan 20, 1998||Becton Dickinson France, S.A.||Cartridge for an injection device|
|US5843036 *||Aug 23, 1996||Dec 1, 1998||Becton Dickinson And Company||Non-dosing cartridge for an injection device|
|US6544234||Aug 7, 1998||Apr 8, 2003||B D Medico S.A.R.L.||Injection device|
|US7011649 *||Nov 8, 2002||Mar 14, 2006||Alza Corporation||Collapsible syringe cartridge|
|US7252651||Jan 7, 2003||Aug 7, 2007||Becton, Dickinson And Company||Disposable injection device|
|US7314464||Aug 17, 2005||Jan 1, 2008||Becton, Dickinson And Company||Pen needle and safety system|
|US7615234||Sep 10, 2002||Nov 10, 2009||Glide Pharmaceutical Technologies Limited||Drug delivery technology|
|US7654983||Nov 8, 2002||Feb 2, 2010||Johnson And Johnson Vision Care, Inc.||Pneumatic powered autoinjector|
|US7666164||Dec 7, 2004||Feb 23, 2010||Becton, Dickinson And Company||Pen needle and safety shield system|
|US7717877||Jul 28, 2004||May 18, 2010||Sid Technologies, Llc||Injecting apparatus|
|US7727223||Sep 10, 2002||Jun 1, 2010||Glide Pharmaceutical Technologies Limited||Drug delivery technology|
|US7862543||Jul 18, 2003||Jan 4, 2011||Glide Pharmaceutical Technologies Limited||Drug delivery system|
|US7905866||Jun 27, 2007||Mar 15, 2011||Becton, Dickinson And Company||Disposable injection device|
|US8088406||Dec 5, 2006||Jan 3, 2012||Glide Pharmaceutical Technologies Limited||Pioneer projectile drug delivery technology|
|US8137313 *||Sep 14, 2004||Mar 20, 2012||Becton Dickinson France S.A.S.||Device for injection of a product, in particular for medical use|
|US8157768||Dec 29, 2010||Apr 17, 2012||Becton Dickinson And Company||Disposable injection device|
|US8162887||Mar 25, 2011||Apr 24, 2012||Abbott Biotechnology Ltd.||Automatic injection devices|
|US8409138||Mar 5, 2008||Apr 2, 2013||Eli Lilly And Company||Delay mechanism for automatic injection device|
|US8574188||Aug 25, 2011||Nov 5, 2013||Glide Pharmaceutical Technologies Limited||Drug delivery technology|
|US8591457||Aug 10, 2005||Nov 26, 2013||Alza Corporation||Method for making a needle-free jet injection drug delivery device|
|US8603040||Mar 26, 2012||Dec 10, 2013||Becton, Dickinson And Company||Disposable injection device|
|US8636704||Apr 29, 2010||Jan 28, 2014||Abbvie Biotechnology Ltd||Automatic injection device|
|US8668670||Apr 10, 2012||Mar 11, 2014||Abbvie Biotechnology Ltd||Automatic injection devices|
|US8708968||Jan 24, 2012||Apr 29, 2014||Abbvie Biotechnology Ltd.||Removal of needle shields from syringes and automatic injection devices|
|US8734394||Feb 24, 2011||May 27, 2014||Eli Lilly And Company||Automatic injection device with delay mechanism including dual functioning biasing member|
|US8758301||Dec 15, 2010||Jun 24, 2014||Abbvie Biotechnology Ltd||Firing button for automatic injection device|
|US8827963||Aug 10, 2010||Sep 9, 2014||Tecpharma Licensing Ag||Administering device with holding mechanism|
|US8858508||Jul 28, 2004||Oct 14, 2014||West Pharmaceuticals Services of Delaware, Inc.||Syringe with automatically triggered safety sleeve|
|US8932264||Aug 11, 2003||Jan 13, 2015||Becton, Dickinson And Company||Medication delivery pen assembly with needle locking safety shield|
|US8998881||Aug 10, 2005||Apr 7, 2015||Alza Corporation||Method for delivering drugs to tissue under microjet propulsion|
|US9017287||Dec 17, 2013||Apr 28, 2015||Abbvie Biotechnology Ltd||Automatic injection devices|
|US9072472||Feb 7, 2006||Jul 7, 2015||Glide Pharmaceutical Technologies Limited||Disposable assembly containing a skin piercing element|
|US9180244||Apr 21, 2011||Nov 10, 2015||Abbvie Biotechnology Ltd||Wearable automatic injection device for controlled delivery of therapeutic agents|
|US9265887||Jan 24, 2012||Feb 23, 2016||Abbvie Biotechnology Ltd.||Automatic injection devices having overmolded gripping surfaces|
|US9339610||Apr 15, 2014||May 17, 2016||Abbvie Biotechnology Ltd||Removal of needle shield from syringes and automatic injection devices|
|US9402957||Apr 25, 2014||Aug 2, 2016||Eli Lilly And Company||Automatic injection device with delay mechanism including dual functioning biasing member|
|US9486584||Nov 6, 2015||Nov 8, 2016||Abbvie Biotechnology Ltd.||Automatic injection device|
|US9561328||Dec 17, 2013||Feb 7, 2017||Abbvie Biotechnology Ltd||Automatic injection device|
|US9592340 *||Aug 8, 2013||Mar 14, 2017||Sanofi-Aventis Deutschland Gmbh||Auto-injector having drive spring switching ground from distal to proximal ends of main body between pushing and retracting syringe needle|
|US20030054044 *||Sep 10, 2002||Mar 20, 2003||Potter David Stuart||Novel drug delivery technology|
|US20030233070 *||Nov 8, 2002||Dec 18, 2003||De La Serna Pedro E.||Pneumatic powered autoinjector|
|US20030236502 *||Nov 8, 2002||Dec 25, 2003||De La Serna Pedro E.||Collapsible syringe cartridge|
|US20040116854 *||Dec 12, 2002||Jun 17, 2004||Abulhaj Ramzi F.||Syringe retractable needle and method|
|US20040133159 *||Jan 7, 2003||Jul 8, 2004||Haider M. Ishaq||Disposable injection device|
|US20050013840 *||Sep 10, 2002||Jan 20, 2005||Potter Charles David Ogilvy||Drug delivery technology|
|US20050027255 *||Jul 27, 2004||Feb 3, 2005||Sid Technologies, Llc||Automatic injector|
|US20050038315 *||Aug 12, 2003||Feb 17, 2005||Slo-Flo Ltd.||Motorized syringe particularly useful for intra-uterine insemination|
|US20050038392 *||Aug 11, 2003||Feb 17, 2005||Becton, Dickinson And Company||Medication delivery pen assembly with needle locking safety shield|
|US20050277895 *||Aug 17, 2005||Dec 15, 2005||Becton, Dickinson And Company||Pen needle and safety system|
|US20050283115 *||Dec 7, 2004||Dec 22, 2005||Lucio Giambattista||Pen needle and safety shield system|
|US20060161111 *||Jul 18, 2003||Jul 20, 2006||Potter David S||Drug delivery system|
|US20060229569 *||Jul 28, 2004||Oct 12, 2006||Sid Technologies Llc||Syringe with automatically triggered safety sleeve|
|US20070112310 *||Jul 28, 2004||May 17, 2007||Sid Technologies Llc||Injecting apparatus|
|US20070275044 *||Dec 5, 2006||Nov 29, 2007||Potter David S||Novel drug delivery technology|
|US20080021390 *||Jun 27, 2007||Jan 24, 2008||Becton Dickinson And Company||Disposable injection device|
|US20090030442 *||Feb 7, 2006||Jan 29, 2009||Charles David Ogilvy Potter||Disposable assembly containing a skin piercing element|
|US20090069754 *||Sep 14, 2004||Mar 12, 2009||Lionel Vedrine||Device for injection of a product, in particular for medical use|
|US20100049125 *||Mar 5, 2008||Feb 25, 2010||Eli Lilly And Company||Delay mechanism for automatic injection device|
|US20110098641 *||Dec 29, 2010||Apr 28, 2011||Becton, Dickinson And Company||Disposable injection device|
|US20110098656 *||May 28, 2004||Apr 28, 2011||Burnell Rosie L||Auto-injection device with needle protecting cap having outer and inner sleeves|
|US20110130723 *||Aug 10, 2010||Jun 2, 2011||Juerg Hirschel||Administering device with holding mechanism|
|US20120283654 *||Sep 29, 2010||Nov 8, 2012||Sanofi-Aventis Deutschland Gmbh||Button Member for Operating a Drive Assembly|
|US20130345643 *||Aug 8, 2013||Dec 26, 2013||Sanofi-Aventis Deutschland Gmbh||Auto-injector|
|US20150148737 *||Feb 2, 2015||May 28, 2015||Peter Forsell||Infusion of drugs|
|CN101998870B||Feb 4, 2009||Dec 25, 2013||特克法马许可公司||Administering apparatus comprising holding device|
|EP0620019A1 *||Mar 17, 1994||Oct 19, 1994||Matthew B. Jore||Single use hypodermic safety syringe|
|EP0666084A2 *||Jan 27, 1995||Aug 9, 1995||Becton Dickinson and Company||Automatic self-injection device|
|EP0666084A3 *||Jan 27, 1995||Oct 8, 1997||Becton Dickinson Co||Automatic self-injection device.|
|EP0796121A1 *||Dec 1, 1995||Sep 24, 1997||Science Incorporated||Medicament dispenser|
|EP0796121A4 *||Dec 1, 1995||Aug 26, 1998||Science Inc||Medicament dispenser|
|EP0824922A1||Aug 19, 1997||Feb 25, 1998||Becton Dickinson France S.A.||An improved cartridge for an injection device|
|EP0824923A1||Aug 19, 1997||Feb 25, 1998||Becton Dickinson France S.A.||Cartrigde with temporarily lockable cap for an injection device|
|EP1285674A1||Aug 19, 1997||Feb 26, 2003||Becton Dickinson France S.A.||A non-dosing cartridge for an injection device|
|EP2067496A1||Jun 23, 2003||Jun 10, 2009||Barry Peter Liversidge||Medical injector|
|WO1989012473A1 *||Jun 20, 1989||Dec 28, 1989||Miskinyar Shir A||Preloaded automatic disposable syringue|
|WO2005014076A2 *||Aug 1, 2004||Feb 17, 2005||Slo-Flo Ltd.||Motorized syringe particularly useful for intra-uterine insemination|
|WO2005014076A3 *||Aug 1, 2004||Aug 18, 2005||Slo Flo Ltd||Motorized syringe particularly useful for intra-uterine insemination|
|WO2005030302A1 *||Sep 14, 2004||Apr 7, 2005||Becton Dickinson France||Device for injecting a product, primarily for medical use|
|WO2009100549A1 *||Feb 4, 2009||Aug 20, 2009||Tecpharma Licensing Ag||Administering apparatus comprising a holding device|
|WO2012022810A2||Aug 19, 2011||Feb 23, 2012||Novo Nordisk A/S||Medical injection device|
|WO2015150578A1||Apr 7, 2015||Oct 8, 2015||Novo Nordisk A/S||Autoinjector having needle shield triggering|
|WO2015197866A1||Jun 26, 2015||Dec 30, 2015||Novo Nordisk A/S||Autoinjector having needle shield triggering|
|WO2017114934A1||Dec 29, 2016||Jul 6, 2017||Novo Nordisk A/S||Autoinjector having needle shield triggering|
|U.S. Classification||604/136, 604/231|
|International Classification||A61M5/20, A61M5/32, A61M5/24|
|Cooperative Classification||A61M5/2429, A61M2005/2073, A61M5/2033, A61M5/3234, A61M5/24, A61M5/3232, A61M5/3287, A61M2005/206|
|European Classification||A61M5/20C, A61M5/24, A61M5/24E2, A61M5/32C2F2F|