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Publication numberUS2761447 A
Publication typeGrant
Publication dateSep 4, 1956
Filing dateMar 26, 1952
Priority dateMar 26, 1952
Publication numberUS 2761447 A, US 2761447A, US-A-2761447, US2761447 A, US2761447A
InventorsHersee Albert C
Original AssigneePalmer Fultz
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Hypodermic syringe
US 2761447 A
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Description  (OCR text may contain errors)

Sept. 4, 1956 A. c. HERSEE HYPODERMIC SYRINGEv Filed March 26, 1952 INVENToR. 6. 7V

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United States Patent R HYPODERMIC SYRINGE Albert C. Hersee, West Chicago, Ill., assigner of two-fifths to Palmer Fultz, Franklin, Ohio v Application March 26, 1952, Serial No. 278,667

8 Claims. (Cl. 12S- 218) This invention relates generally to hypodermic syringes and more particularly to a syringe adapted to miX parenteral medicaments which are relatively unstable in solution.

Ever since the miracle antibiotic penicillin gained prominence as a common drug for the medical profession, its producers have been confronted with several problems. It is of primary importance, of course, to produce a therapeutically superior product but, in addition, it is also important to make administration of the medicament as painless and convenient as possible for the physician and his patient. An answer to the first problem lies in the recent development of a combination penicillin product containing both procaine penicillin and sodium soluble crystalline penicillin together in a ratio of three to one. As for the second problem, certain developments have been made in disposable cartridges or ampules for the hypodermicsyringe.. With such disposable cartridges it has always been necessary to use medicaments that are already mixed and hence the use of such cartridges has been limited to drugs that are stable in solution. Unfortunately it has never been possible to combine the therapeun'cally superior penicillin products, which are unstable in solution, with the convenient disposable cartridge type syringe.

The present invention meets the existing need with novel apparatus for combining the convenience of disposable cartridges with the therapeutic advantages of certain types of penicillin or any other parenteral medicament which cannot be stored at length with diluent added.

Further objects and advantages of the present invention will be apparent from the following description, reference being had to theV accompanying drawings wherein preferred forms of embodiments of the invention are clearly shown.

In the drawings:

Fig. l is a side elevational view of a syringe formed in accordance with the present invention;

Fig. 2 is a side elevational view of the removable handle for the disposable body member of the present invention;

Fig. 3 is a side view, partially in elevation and partially in section, of a disposable body member formed in accordance with the present invention;

Fig. 4 is a side view, partially in elevation and partially in section, of a casing member utilized in the presen syringe structure;

Fig. 5 is a fractional sectional view of a hypodermic needle utilized in a syringe of the present invention;

Fig. 6 is another sectional view of the disposable body member of Fig. 3 showing a plunger rod positioned for mixing the contents of the body member;

Fig. 7 is a sectional view showing the disposable body member of Fig. 3 with the plunger in the sealing position;

Fig. 8 is a side sectional view showing the disposable body member of Fig. 3 partially inserted' into the casing member of Fig. 4;

Fig.`9 is a side sectional view ofthe syringe of the Faterated Sept. 4, 1955 present invention with the contents mixed and ready for injection;

Fig. 10 shows a second embodiment of the present invention; and l Fig. 1l shows a third embodiment of the present invention.

Referring to the drawing, and more particularly to Fig. l, a tubular casing member is indicated generally at 10. A body member indicated generally at 11 is shown carried in the tubular casing member 1). A hypodermic needle 14 is carried by the lower end of the tubular casing member 10.

l prefer to make the body member 11 in a disposable embodiment which may be discarded after use. It should be noted, however, that the invention herein set forth is not limited to such preferred embodiment. A plunger rod 12 is slidably carried in the body member 11 and a handle 13 is shown fastened to the plunger rod. The handle 13 may be of the removable type, as best seen in Fig. 2, or it may be integrally formed with the plunger rod 12 as is shown in Figs. l() and 1l. The removable handle section is preferable where a compact disposable body member such as is shown in Fig. 3, is desired.

The tubular casing member 10 is provided with an open top portion 15 which may be ared outwardly as shown in Fig. 4. Such flared portion serves to engage the shoulder 16 of the body member 11 when it is positioned in the casing member. The flared portion 15 and the shoulder 16 are shown in abutting relationship in Fig. 9. These abutting portions serve to add rigidity to my syringe when the body member has been placed in the casing member and when the plunger rod and handle are being pressed inwardly during an injection.

The needle 14 is best seen in Fig. 5 where it is shown partially inserted into the bottom 18 of the tubular casing member 10. The bottom of the casing member may be provided with a boss 19 through which the hole 20 is formed for receiving the upper needle portion 21. A point such as is shown at 22 may be formed on the upper needle portion to provide means for piercing the body member. A cup 23 is mounted on the needle 14 to mate with the boss 19 which is formed on the lower end of the casing member. The cup 23 and the boss 19 can be tapered at their mating surfaces as shown in the drawing or they can be fastened together by threads in the conventional manner. In either event, however, it is preferable to have the needle 14 easily removable from the casing member 10 so that it can be readily replaced after use.

Fig. 3 shows a disposable body member formed in accordance with the present invention. An upper chamber 26 and a lower chamber 27, which is of lesser diameter than the upper chamber, are shown formed in the body member. These two chambers are separated by the plunger rod 12 which is normally inserted into the upper portion of the lower chamber 27 as shown in Fig. 3. Prior to use, the disposable body members are stored with their plunger rods 12 in the sealing position of Fig. 3. At the same time, in the preferred form, the upper chamber 26 contm'ns only the dilnent 30 and the lower chamber contains only the medicament 31. As the plunger rod 12 extends through the upper chamber 26 and outside the syringe, a sealing ring 32 of resilient material such as rubber is provided to slideably mount the plunger rod in the body member and to seal the junction of the plunger rod 12 with the upper end wall 34 of the body member. To seal the junction of the plunger 12 with the inner wall 35 of the lower chamber 27, a tip 36 may be attached to the lower end of plunger rod 12. The

It should be noted that by providing a close iit between the plunger rod V12 and the inner Wall 35 of the lower chamber, the tip 35 can be eliminated withoiitdepa'tng' from the spirit of my invention. In the preferred form, however, I provide the plunger tipy 36 for reasons of economy in fabricating the disposable body members.-

A pierceable seal 3S is provided on the lowerencloiIV the disposable body member as is best seen in ,Figi 3 The hole 39 is formed in the lower end 40 of the disposable body member to connect the lower chamber 27 the inner surface of the membrane 3S and to receivethe upper portion 21 of Athe needle 14y after the needle has pierced the membrane 38.

The disposable body member 11 and 'the plunger rod. 12"

are preferably made of glass, but either or bothY ofsuch. members can be made of other suitable materials sch'yas plastics which are not reactive with the particular nedicaments te be administered. The handle 13, the' casing. member and the needle 14 can suitablyl beinade f. metal such as is commonly used for instruments of this' type.

adapted to apply successive administrations to different patients fromva single disposable body member. Such is possible' with the body member 45 of ig. 10 whihv isV adapted to be resealed after a portion of Athe contents have been ejected and to be removed and reinserted into the c a'sing memberr49 so that the needle 14 can be replaced with a new sterilized needlefor the next succeeding patient. To adapt the body member 45 for multiple injections, the pierceable seal 51 formed of a self-sealing material and the hole 50 in ,the body member is made larger than the corresponding hole 39 of the previously described embodiV ment. Hence to repierce the seal 51, it is only necessary to withdraw the body member 4S from the casing meinber 49, change needles, and reinsert the body member into the casing member so that the new needle pierces the seal 51. It should be noted that the needle 14 is mounted to the casing member 47 in a position eccentric with the seal 51. This is done so that the successive needles can be directedeto pierce the seal 51 in different places. Il?

the needles were centrally mounted they would repeatedly pierce the seal 51 in the same place, namely the center. In this second embodiment it is preferable to provide the plunger rod 43 with graduations 44 to indicate the amount of medicament that is used during each succeeding inje tion. A needle mount 48 is shown threaded into the hole 47 in the casing member 49. In addition, Fig'. 10 showsv ringer grips 46fwhich may be formed on the casing niember 49.

A third embodiment of the present invention is shown in Fig. 1li This embodiment provides a simplied syringe in which the outer and .inner walls of the body member 52 are formed as cylindrical surfaces. A tapered portion 55 is formed in the inner wall between the uppe'rehamber' S3 and the lower chamber S4. Such tapere'dportionservesto guide the plunger rod 56 into the lower ehaine ber 54. In the embodiment of Fig. ll, the casing inernbers 10 and 49 of the former embodiments have been elim` inated and in their place a needle mount 63 is provided for adaptinga hollow needle 65 to the lower portion of the body member 52. To seal the junction between the needle'mount and the body member, a gasket '64 is prof face of the vplunger rod 56. It should be noted thatvther stopper 57 is preferably formed with a relatively thincen-v ter'portion so that the wall surface 59 presents amnimum' of resistance to movement of theplunger rod-56a Atlthe seidfenambee erf'iess'er diameter beiagfdrdiedewin'r acylindrical inner wall portion, a plungerr'd eitndin'g ably i'iade vthick'relative to the center portion" so that" the outer stopper surface 58 is of suihciently large area to be frictionally retained in position by the inner surface of the upper chamber 53 when the plunger rod is manipulated.

A sirnilar type of stopper-,construction is utilized in the stopper 60 provided to seal the bottom opening in body member 52. Herethe outer wallo-l-'on the stopper is made of sulicient area tol be frictionally retained by.v theV cylindrical inner wall of the lower chamber vSl-when pressure is applied to the stopper in piercing it with the needle. The stopper 60 is preferably'l formedwitha curved Vinner wall 62 to provide a relatively thin central` portion which may be readily pierced by the needle.

In operation, a disposable body member is used which will appear as shown in Fig. 3 with the contents of the lower chamber separated fromthe contents-othe-upper chamber by the plunger rdrwhich is, at` thev outset, posi.-V

beris pushed down ofver the` inverted body member in4 the'nianner' 'shown in Fig. 8'. As the body member is inserted into the casing member, the needle-` is caused to pierce the seal and enter the lower chamber. The plunger rod is' nowadjusted to rernove'any air that may be present in' 'thelower chamber. The syringe will now appear as.v shown in Fig. 9' and isr'edy for administering Ythe medicament inthe 'usual manner.

while meterme df embediments ef Athe present teven. Y tin as herein disclosed cons titte preferred forms; it is to" be understood that other forms 'might bewadopted, ll-

comng within the scope of the yclaims'whieh follow.

I claim: 1. kA hypodermic syringecomprising two chamberswith theichan'rbers being of diterentdianieters, with the chambei' ofgreater diameter having a cylindricalinner surface' extending' te'` an exit port, and va plunger rod slidngly engageable withthe chamber of'lesser diameter and extend# in'gtlroughV the opening inthe top of the chanlzier` of greater diameter outside the syringe,J and a stopper fric# tionally Vi'etiffzel'byV thev cylindrical inner srfa'ce at the Witlrredeedfrictional opposition t its sliding therein.

2. A hypodermic syringe comprisinga body n1e1`r'1berv having two storage chambers with thechanibersbeirrgof different dimetersand having a connecting port, with the chamber of lesser dimet'erhaving a cylindrical inner surfaee'citending'tol an eX'it 'portrt an end of sid Chamber Opposite saidirlriectillgV portydia'pllmgefod 1101"; mally' cai-fried partially inserted inisaid ,storage chamber of lesser" diameter t6 form' reivbleedclosre fol'l said chamber and slidngly'engageable Withthe'chrnbe'r Ofle'ssel diaiefr ail'd lfeiidirigth'oilgh th Otherhmber andv outside thev syringe; pircablfstpper friction-f ally retained bythe cylindrical inner surfa'eeA attheeirity thieknesetdfedueeltne fesisfene'effe piercing-and. hyper tei pierce' through the kstepper and fe'- extend inte said f chamber of lesser diameter.

3; -A hypodermio'fsyrigecomprising 'ajb'ody ncrber,

a drug- 'ehemberiandadimenrehamberwirnihe emanen being: eff differentdiameters and ifnneefed by e perf,

from 'tside the syring'ethrough the Ch'riber 'of greater diameter and having an inner end normally insertably positioned in the end of said chamber of lesser diameter adjacent to said port whereby said inner end of the plunger rod forms an end closure for said chamber of lesser diameter, said plunger rod being withdrawable from said normal position to effect removal of said end closure whereby contents normally carried in said chamber of greater diameter can enter the chamber of lesser diameter, and said plunger rod being extendable from said normal position to move said inner end beyond said normal position and in sliding engagement with said cylindrical inner wall portion for ejecting the contents from said chamber of lesser diameter and a hypodermic needle slideably carried by said body member and adapted to pierce and extend into the chamber of lesser diameter at an end of said chamber opposite to said port upon sliding of said needle relative to said body member.

4. A hypodermic syringe comprising a body member, a drug chamber and a diluent chamber with the chambers being of dierent diameters and connected by a port, said chamber of lesser diameter being formed with a cylindrical inner wall portion, a plunger rod extending from outside the syringe through the chamber of greater diameter and having an inner end normally insertably positioned in the end of said chamber of lesser diameter adjacent to said port whereby said inner end of the plunger rod forms an end closure for said chamber of lesser diameter, said plunger rod being withdrawable from said normal position to effect removal of said end closure whereby contents normally carried in said chamber of greater diameter can enter the chamber of lesser diameter, and said plunger rod being extendable from said normal position to move said inner end beyond said normal position and in sliding engagement with said cylindrical inner wall portion for ejecting the contents from said chamber of lesser diameter, a hypodermic needle slideably carried by said body member and adapted to pierce and extend into the chamber of lesser diameter at an end of said chamber opposite to said port upon sliding of said needle relative to said body member, a needle mount slideably carried by said body member, and a hypodermic needle carried on said mount, an end of said needle being normally positioned in confronting relationship with an end of said chamber of lesser diameter opposite to said port, said needle being thereby adapted to pierce and extend into said chamber of lesser diameter upon sliding of said needle mount relative to said body member.

5. A hypodermic syringe comprising a body member, a drug chamber and a diluent chamber with the chambers being of diierent diameters and connected by a port, said chamber of lesser diameter being formed with a cylindrical inner wall portion, a plunger rod extending from outside the syringe through the chamber of greater diameter and having an inner end normally insertably positioned in the end of said chamber of lesser diameter adjacent to said port whereby said inner end of the plunger rod forms an end closure for said chamber of lesser diameter, said plunger rod being withdrawable from said normal position to effect removal of said end closure whereby contents normally carried in said chamber of greater diameter can enter the chamber of lesser diameter, and said plunger rod being extendable from said normal position to move said inner end beyond said normal position and in sliding engagement with said cylindrical inner wall portion for ejecting the contents from said chamber of lesser diameter, a hypodermic needle slideably carried by said body member and adapted to pierce and extend into the chamber of lesser diameter at an end of said chamber opposite to said port upon sliding of said needle relative to said body member, a needle mount slideably carried by said body member, a hypodermic needle carried on said mount, an end of said needle being normally positioned in confronting relationship with an end of said chamber of lesser diameter opposite to said port, said needle being thereby adapted to pierce and extend into said chamber of lesser diameter upon sliding of said needle mount relative to said body member, and a gasket seal between said body member and said needle mount.

6. A hypodermic syringe for mixing and injecting two separately contained substances, said syringe comprisin.U two storage chambers with the chambers being of different diameters and having a connecting port, a quantity oi a drug carried in one of said chambers, a quantity of a diluent carried in the other of said chambers, said chamber of lesser diameter being of suicient size to hold all of said two quantities of drug and diluent, a plunger rod slidingly engageable with the chamber of lesser diameter and carried partially inserted in said storage chamber of lesser diameter, prior to institution or" the mixing portion of the cycle of operation, to form a removable closure for sealing the port, said plunger rod extending through the chamber of greater diameter and outside the syringe and said chamber of greater diameter having a portion of its inner surface tapered toward the port to guide the plunger rod into the chamber of lesser diameter.

7. A hypodermic syringe for mixing and injecting two separately contained substances, said syringe comprising a drug chamber and a diluent chamber, said chambers being of different diameters, a quantity of a drug carried in one of said chambers, a quantity of a diluent carried in the other of said chambers, said chamber of lesser di ameter being of sutiicient size to hold all of said two quantities of drug and diluent, and a plunger rod carried partially inserted in said chamber of lesser diameter, prior to institution of the mixing portion of the cycle of operation, to form a removable seal between said two chambers and slidingly engageable with the chamber of lesser diameter and extending through the other chamber and outside the syringe.

8. A hypodermic syringe for mixing and injecting a drug and a diluent comprising a drug chamber and a diluent chamber with the chambers being of dierent diameters and connected by a port, said chamber of lesser diameter being formed with a cylindrical inner Wall portion, a quantity of a drug carried in one of said chambers, a quantity of a diluent carried in the other of said chambers, said chamber of lesser diameter being of sufcient size to hold all of said two quantities of drug and diluent, and a plunger rod extending from outside the syringe through the chamber of greater diameter and having an inner end insertably positioned, prior to institution of the mixing portion of the cycle of operation, 1n the end or said chamber of lesser diameter adjacent to said port whereby said inner end of the plunger rod forms an end closure for said chamber of lesser diameter, said plunger rod being withdrawable to elect removal of said end closure from said chamber end whereby one of said quantities carried in said chamber of greater diameter can enter the chamber of lesser diameter, and said plunger rod being extendable from said normal position to move said inner end in sliding engagement with said cylindrical inner wall portion for ejecting both of said quantities from said chamber of lesser diameter.

References Cited in the file of this patent UNITED STATES PATENTS 1,275,315 Smith Aug. 13, 1918 1,316,222 Covell Sept. 16, 1919 1,529,659 Marcy Mar. 17, 1925 1,614,067 Heublein Ian. 11, 1927 2,134,144 Pincock Oct. 25, 1938 2,453,591 Poux NOV. 9, 1948 2,604,095 Brody July 22, 1952 FOREIGN PATENTS 172,659 Great Britain June 29, 1922

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US1275315 *Mar 14, 1918Aug 13, 1918Thomas O L SmithBottle.
US1316222 *May 1, 1918Sep 16, 1919 Planooraph co
US1529659 *Dec 24, 1921Mar 17, 1925Marcy Ernest HHypodermic instrument
US1614067 *Mar 12, 1925Jan 11, 1927Oskar Heublein WilhelmAmpulla for injection liquids comprising separated compartments
US2134144 *Sep 22, 1936Oct 25, 1938Pincock Douglas FHypodermic syringe
US2453591 *Nov 4, 1946Nov 9, 1948Noel J PouxHypodermic syringe
US2604095 *Dec 18, 1948Jul 22, 1952Nathan BrodyDisposable syringe
GB172659A * Title not available
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US2896622 *May 17, 1955Jul 28, 1959Gruenenthal ChemieInjection ampoules for several media and intended to be used once
US2907329 *Jan 26, 1955Oct 6, 1959Cohen Milton JHypodermic syringe
US3052240 *Jan 29, 1959Sep 4, 1962SilverDisposable hypodermic syringe
US3058467 *Oct 23, 1959Oct 16, 1962Jean-Marie FaureHypodermic syringes
US3076456 *Mar 7, 1960Feb 5, 1963Elsie B HuntHypodermic syringe
US3958570 *Sep 3, 1974May 25, 1976Vogelman Joseph HSyringes and syringe capsules
US4664655 *Mar 20, 1986May 12, 1987Norman OrentreichHigh viscosity fluid delivery system
US4758234 *Mar 17, 1987Jul 19, 1988Norman OrentreichHigh viscosity fluid delivery system
US5158546 *Aug 7, 1991Oct 27, 1992Habley Medical Technology Corp.Controlled action self-mixing vial
US6743194 *Mar 28, 2002Jun 1, 2004Igal SharonMulti-compartment syringe
US6960195 *Jul 30, 2001Nov 1, 2005Jochen HeinzMetering receptacle
US20130041344 *Sep 15, 2010Feb 14, 2013Sanofi-Aventis Detuschland GmbhMedication Delivery Device and Method for Dispensing a Medication
WO2003082369A2 *Mar 24, 2003Oct 9, 2003Mlis Projects LtdA multi-compartment syringe
Classifications
U.S. Classification604/89
International ClassificationA61M5/24, A61M5/28, A61M5/19
Cooperative ClassificationA61M5/284, A61M5/19, A61M5/2448
European ClassificationA61M5/24M, A61M5/19, A61M5/28M