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Publication numberUS2785188 A
Publication typeGrant
Publication dateMar 12, 1957
Filing dateFeb 4, 1952
Priority dateFeb 4, 1952
Publication numberUS 2785188 A, US 2785188A, US-A-2785188, US2785188 A, US2785188A
InventorsClarence S Coe
Original AssigneeUnion Oil Co
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Method for preparing 3, 3'-5, 5'-tetraalkyl-4, 4'-diphenoquinones
US 2785188 A
Abstract  available in
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Claims  available in
Description  (OCR text may contain errors)

NIETHOD FOR PREPARING 3,3'-5 ,5-TETRA- ALKYL-4,4'-DIPHENOQUINONES Clarence S. Coe, Rolling Hills, Calif., assignor to Union Oil Company of California, Los Angeles, Calif., a corporation of California i No Drawing. Application February 4, 1952, Serial No. 269,891

6 Claims. (Cl. 260-396) This invention relates to improved methods for preparing gasoline stabilizers of the 4,4'-dihydroxy diphenyl type, wherein all four positions ortho to the hydroxy groups are substituted with alkyl groups. In particular the invention concerns an improved method for preparing 3,3'-5,5-tetra-alkyl-4,4'-diphenoquinones, which may be susequently reduced to the corresponding diphenols.

It is an object of this invention to provide inhibitors for gasolines which are highly effective in very small proportions.

A further object is to provide convenient and economical methods for preparing such inhibitors.

Other objects will appear from the more detailed description which follows.

U. S. Patent No. 2,479,948 discloses a class of inhibitors which may be designated as 3,5,3',5'-tetra-alkyl-4,4'-dihydroxy diphenyls wherein not more than two of the alkyl groups are tertiary alkyl groups. The compound 3,3'-5,5-tetra-tert-amyl-4,4'-dihydroxydiphenyl is disclosed therein as being relatively ineffective as an inhibitor, being less active than the reference standard, cresylic acids. The other compounds disclosed, which contain primary and/or secondary alkyl groups, while stated to be relatively active as inhibitors, are more or less soluble in alkaline solutions. It has now been found that the specific compound 3,3-5,5'-tetra-tert-butyl-4,4- dihydroxy diphenyl:

IDS Il)8 OH OH O(CHa)s ((CHr):

nited States Patent 0 tions in the presence of a copper catalyst to produce a corresponding p-diphenoquinone, and then hydrogenating the diphenoquinone under mild hydrogenating conditions to produce the corresponding dihydroxy diphenyl. These reactions may be summarized as follows:

, STEPI R R R C 3 Q OH Hill O: =O+H8l Salt alkali on R1 R1 R1 STEP II wherein R and R1 may be any inert substituents, but are preferably tertiary alkyl groups. 7

2,785,188 Patented Mar. 12, 1957 The prior art methods for preparing these compounds have generally involved an oxidation of a non-halogenated phenol with strong acidic oxidizing agents such as chromic acid, followed by hydrogenation of the resulting diphenoquinone. The present process is carried out under mild alkaline oxidizing conditions at low temperatures, resulting in a minimum of undesired side reactions and decomposition. The process is also easily controlled, and avoids the use of dangerous or corrosive reagents.

Examples of phenols which may be employed in Step I of my process include 2,6-di-tert-butyl-4-chlorophenol; 2,6 di isopropyl 4 chlorophenol; 2,6 diethyl 4- chlorophenol; 2,6 dihexyl 4 chlorophenol; 2 tertbutyl 6 ethyl 4 chlorophenol; 2 tert amyl 6- tert butyl 4 chlorophenol; 2 tert butyl 6 cyclohexyl 4 chlorophenol; 2 methyl 4 chlorophenol, or any of the bromo or iodo analogs of the above compounds.

The oxidizing conditions employed in Step I above generally involve air or other oxygen containing gas as the oxidizing agent. Finely divided reduced copper powder is the preferred catalyst, although other metal powders may be employed. The alkaline material acts as a halogen acceptor, and may be any alkaline acting material such as ammonia, calcium hydroxide, sodium hydroxide, primary, secondary or tertiary amines, sodium carbonate etc. The reaction may be carried out at any desired temperature and pressure. Normal atmospheric pressures and room temperatures are ordinarily preferred. A solvent such as ethanol may be employed if desired. It is preferred that some water should be present in the reaction mixture, since this appears to accelerate the reaction. If refluxing is employed it is preferred to employ either Water or some relatively low boiling solvent in the reaction mixture in order to maintain a reflux temperature below about C., thereby avoiding thermal decomposition of the reactants or products. Air may be bubbled slowly through the mixture throughout the reaction period or a suitable solid or liquid oxidizing material may be present in the mixture.

After completion of the oxidation, the solid diphenoquinone, which ordinarily separates as bright red crystals, is filtered from the mixture and washed with water to remove excess alkaline materials and salts.

The diphenoquinone is then reduced with hydrogen under mild hydrogenation conditions, as for example with zinc and acetic acid, or tin and hydrochloric acid. Care must be exercised to insure that the hydrogenation conditions are not sufliciently drastic to cause the benzene rings to also become partially or wholly hydrogenated. Only two atoms of hydrogen are required to reduce the diphenoquinone to the corresponding dihydroxy diphenyl. The above hydrogenating materials will ordinarily add the desired hydrogen selectively at normal temperatures and pressures. With higher temperatures and/or pressures,'or with other more drastic hydrogenation catalysts, as for example Raney nickel, the reaction time must be closely controlled in order to avoid undesired types of hydrogenation, or scission of the bicyclic structure.

After hydrogenation is completed, as may be evidenced by the disappearance of color from the reaction mixture, the dihydroxy diphenyl compound may be recovered by filtration, washed with water, and if desired recrystallized from solvents such as alcohol, acetone, benzene, etc.

In order to illustrate the method of preparing these compounds, the following examples are cited, which should be considered as illustrative only and not limitative:

Example IA 20 gms. of 2,6-di-tert-butyl-4-chrophenol was introduced into a flask and treated at room temperature with a mixture of 70 ml. mono-n-butylamine, 20 ml. of water, and 0.2 gm. of copper powder. Air was bubbled slowly through the mixture at atmospheric pressure for about eight hours. During the reaction the mixture was observed to become red in color. Upon cooling, bright red needles of 3,3'-5,5-tetra-tert-butyl-diphenoquinone, precipitated out, and were separated by filtration. Upon washing with water and recrystallization from benzene, the crystals were found to have the following characteristics:

Melting Point, 229 C.

Analysis:

Found H, 9.32%; C, 82.6% Calculated 9.86%; 82.3%

Mol.Wt.: I

Found 398 Calculated 408.6

The phosphomolybdic acid test for hindered phenols was negative.

Example I-B 15 gms. of the 3,3-5,5-tetra-tert-butyl diphenoquinone was mixed in a fiask with about 3.0 gms. of zinc dust. Dilute acetic acid was admitted periodically over a period of about 3 hours at room temperature. At the end of this period, the red color of the quinone was observed to completely disappear. The light colored crystals obtained on cooling were removed by filtration and washed with water. Upon recrystallization fro-m benzene, pure 3,3'-5,5-tetra-tert-butyl-4,4'-dihydroxy diphenyl was obtained in almost quantitative yield. The material had the following characteristics:

Melting Point, 184 C.

Analysis:

Found C, 81.1%; H, 10.2% Calculated C, 81.9%; H, 10.3% M01. Wt.:

Found 420 Calculated 411 The ultra violet spectra showed the typical characteristics of phenolic OH groups when compared in ethanol and iso-octane solution.

Example [I 3 gms. of 2,6-di-tert-butyl-4-chlorophenol was dissolved in 30 ml. of 95% ethanol and 0.1 gm. of copper powder was added. Air was slowly bubbled through the mixture while 12 ml. of concentrated ammonium hydroxide solution was gradually added. The reaction was continued at room temperature for about 2 hours. At the end of the reaction period excess ammonia and alcohol was removed by distillation. The remaining solid was water washed, then redissolved in benzene, filtered and recrystallized. 3,3-5,5-tetra-tert-butyl diphenoquinone Was obtained in about 80% yield, which gave upon hydrogenation the corresponding clihy-d-roxy diphenyl as in Example LS.

Example Ill Example 11 was repeated using a 10% sodium hydroxide solution in place of the ammonium hydroxide. After 10 hours treatment with air at reflux temperature, a somewhat smaller yield of 3,3-5,-5-tetra-tert-butyl diphenoquinone was recovered by the purification procedure of Example II.

Example IV The procedure of Example I is repeated using as the starting material 2,6-di-isopropyl-4-bromo phenol. A good yield of 3,3-5,5'-tetra-isopropyl diphenoquinone is obtained, which gives 3,3-5,5'-tetra-isopropyl-4,4-dihydroxy diphenyl upon mild hydrogenation with tin and hydrochloric acid. a

The procedures outlined in the above examples may be employed for preparing substantially any substituted 4,4- dihydroxy diphenyl by employing as the starting material the appropriate substituted 4-halophenol in place of the halophenols employed in the examples. The slight modifications of procedure which may be necessary to accommodate the slight difierences in solubility and reactivity of the various starting materials will be obvious to those skilled in the art. The above procedures are particularly valuable for preparing sterically hindered dihydroxy diphenyls, wherein the reactivity of the phenol groups is hindered by the presence of a tertiary alkyl group in each of the positions ortho to the hydroxy groups.

The compound prepared in Example I-B, namely 3,3- 5,5-tetra-tert-butyl-4,4-dihydroxy diphenyl is found to be particularly valuable as an inhibitor for petroleum products. It is active in small proportions, ranging from about 0.0001% to 0.2%, and is very insoluble in aqueous alkaline solutions, such as the alkaline solutions employed in sweetening gasoline stocks. While this material is particularly suitable for use in cracked gasolines, it is also satisfactory for use as a stabilizer in other oxidizable organic compounds such as aviation gasoline, turbine oils, lubricating oils, unsaturated hydrocarbon polymers, resins, turpentine, corn oil, cottonseed oil, fish oils, animal oils, fats, oils, soaps, terpenes, essential oils, cellulose esters and ethers etc. The proportion of inhibitor to be used in these materials is within the same range as mentioned above in connection with petroleum products. With cracked gasolines, about 10 pounds of the inhibitor per 1,000 barrels of gasoline may suitably be used, which corresponds to about 0.0035% by weight.

Cracked gasolines containing from 0.001% to 0.1% of 3,3-5,5-tetra-tert-butyl-4,4'-dihydroxy diphenyl are found to exhibit substantially increased induction periods when tested according to the standard oxygen absorption test. In this test oxygen is bubbled through the sample of gasoline at 150 C., and the time required for a given amount of oxygen absorption is measured. This test, while being a standard method, does not necessarily correlate accurately in all gasoline stocks with the overall stability in actual use of the particular gasoline. For gasolines derived from western crudes, a more reliable index of stability is usually obtainable by a determination of their peroxide content. High peroxide numbers indicate low stability and low peroxide numbers indicate high stability. These peroxide numbers are determined by titrating a sample of the gasoline with a reducing solution consisting essentially of 0.01 N titanous chloride. This method is more particularly described in U. 0. P. Laboratory Test Methods for Petroleum and its Products, Universal Oil Company (1940).

Example V Peroxide No.

Sample after 24 after 72 alter 17 hours hours days exposure exposure exposure to air to air to air 75 This data hows that 3,3-5,5'-tetra-tert-butyl-4,4' dihydroxy diphenyl is efiective in extremely small amounts in preventing the formation of peroxides in cracked gasolines, and that it retains its activity for a longer period of time than its monocyclic analog, 2,6-di-tert-butyl p-cresol. Inasmuch as these peroxides are considered to be precursors or essential factors in the formation of gums in gasolines, it is clear that the above compound is a highly effective stabilizer.

The foregoing disclosure of this invention is not to be considered as limiting since many variations may be made by those skilled in the art without departing from the scope or spirit of the following claims.

Iclalim:

l. A method for preparing a 3,3-5,5-tetra-alkyl-4,4'- diphenoquinone which comprises oxidizing a 2,6 dialkyl 4-halophenol with a mild oxidizing agent in the presence of an alkaline-acting material and a metallic copper catalyst.

2. A method as defined in claim 1 wherein said oxidizing agent is an oxygen-containing gas.

3. A method for preparing a 3,3'-5,5'- tetra-tert-alkyl- References Cited in the file of this patent UNITED STATES PATENTS Tishler et al. Feb. 23, 1943 Luten et a1 Aug. 23, 1949 OTHER REFERENCES Chemical Abstracts, vol. 32, Co]. 5802-5803 (1938).

Abstracting an article of C. V. Bordeianu in Ann. Sci.

University, Jassy, Pt. I, 23.

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Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US2900417 *Mar 21, 1955Aug 18, 1959Ethyl Corp3,3' - diisopropyl - 5,5' - di - tert - butyl-4,4'-dihydroxydiphenyl, its preparation and use
US2905674 *Oct 17, 1956Sep 22, 1959Ethyl CorpMethod for preparing 3, 3', 5, 5'-tetraalkyl-4, 4'-diphenoquinones
US2911315 *Jan 23, 1958Nov 3, 1959Dow Chemical CoEthyl cellulose compositions
US2940988 *Nov 23, 1956Jun 14, 1960Shell Oil CoStable free radicals
US3004042 *Sep 15, 1958Oct 10, 1961Shell Oil CoFree radicals of 4,4'-bis(2,6-di-tert-alkylhydroxyphenyl) amines
US3095287 *Aug 28, 1961Jun 25, 1963Ethyl CorpJet fuel compositions
US3156543 *Nov 21, 1963Nov 10, 1964Ethyl CorpStabilized organic material
US3210384 *Nov 21, 1962Oct 5, 1965Gen ElectricProcess for the preparation of 3, 3', 5, 5'-tetra-substituted diphenoquinone
US3219625 *May 29, 1961Nov 23, 1965Gen ElectricProcess for oxidizing phenols to polyphenyl ethers and diphenoquinones
US3219626 *May 29, 1961Nov 23, 1965Gen ElectricProcess for oxidizing phenols to polyphenyl ethers and diphenoquinones
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CN103183587A *Feb 21, 2013Jul 3, 2013西安力邦制药有限公司Novel 3,3',5,5'-tetraisopropyl-4,4'-2-diphenol crystal forms I, II and III and preparation methods thereof
CN103183587BFeb 21, 2013Jul 16, 2014西安力邦制药有限公司Novel 3,3',5,5'-tetraisopropyl-4,4'-2-diphenol crystal forms I, II and III and preparation methods thereof
EP0040516A1 *May 14, 1981Nov 25, 1981Atlantic Richfield CompanyStabilization of hydrocracked oils with certain dihydroxy diphenyl components
EP2915584A1Mar 5, 2014Sep 9, 2015Basf SeRuthenium-phenol catalysts for transfer hydrogenation reactions
Classifications
U.S. Classification552/304, 524/343, 568/747, 426/546, 554/7, 252/404, 44/440
International ClassificationC07C50/08, C07C46/08, C10L1/185
Cooperative ClassificationC10L1/1857, C10M2207/024, C10M1/08, C07C50/08, C07C46/08
European ClassificationC07C46/08, C10L1/185C, C07C50/08, C10M1/08